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Do Manh Cuong, Mariadhas Valan Arasu, Jin Jeon, Yun Ji Park, Soon-Jae Kwon, Naif Abdullah Al-Dhabi, Sang Un Park
Carotenoids, found in the fruit and different organs of bitter melon ( Momordica charantia ), have attracted great attention for their potential health benefits in treating several major chronic diseases. Therefore, study related to the identification and quantification of the medically important carotenoid metabolites is highly important for the treatment of various disorderes. The present study involved in the identification and quantification of the various carotenoids present in the different organs of M...
December 2017: Saudi Journal of Biological Sciences
Anzel Bahadır, Ayşe Ceyhan, Özlem Öz Gergin, Betül Yalçın, Menekşe Ülger, Tuğçe Merve Özyazgan, Arzu Yay
OBJECTIVE: Cisplatin (CDDP) has been known to be an effective antineoplastic drug; however, it has a cardiotoxic effect. Curcumin (CMN) and beta-carotene (BC) have been suggested to protect biological systems against CDDP-induced damage. The current study was conducted to evaluate the possible protective roles of CMN and BC on CDDP-induced cardiotoxicity in rat cardiac tissues. METHODS: A total of 49 adult female Wistar albino rats were equally divided into seven groups as follows: control (no medication), sesame oil (1 mg/kg), CDDP (single dose injection two times as once a week, 5 mg/kg/week), BC (100 mg/kg), CDDP+BC (pretreated BC for 30 min before CDDP injection), CMN (200 mg/kg), and CDDP+CMN (pretreated CMN for 30 min before CDDP injection)...
March 2018: Anatolian Journal of Cardiology
Agnieszka Wendołowicz, Ewa Stefańska, Lucyna Ostrowska
The diet is directly connected not only with the physical status but also with the functioning of the brain and the mental status. The potentially beneficial nutrients with a protective effect on the nervous system function include amino acids (tryptophan, phenylalanine, tyrosine, taurine), glucose and vitamins C, E, D and beta-carotene, B group vitamins (vitamin B12, vitamin B6, vitamin B4, vitamin B1) and minerals (selenium, zinc, magnesium, sodium, iron, copper, manganese, iodine). The presence of antioxidants in the diet protects against oxidative damage to nervous system cells...
2018: Roczniki Państwowego Zakładu Higieny
Kari A Weber, Wei Yang, Suzan L Carmichael, Gary M Shaw
BACKGROUND: We previously explored associations between nutrients including folate and other macro and micronutrients and risks of anophthalmia or microphthalmia in the National Birth Defects Prevention Study. In the current study, we expand those previous results with larger sample sizes and conduct analyses with an additional diet quality index using more recent data. METHODS: The National Birth Defects Prevention Study is a population-based, multicenter case-control study of over 30 major birth defects, with estimated due dates from October 1997 to December 2011...
March 5, 2018: Birth Defects Research
Jamie Perin, Gregory Prokopowicz, Margaret Furtado, Konstantinos Papas, Kimberley E Steele
BACKGROUND: Vitamin and mineral deficiencies are common following Roux-en-Y gastric bypass (RYGB) and can lead to significant morbidity, but little research on the efficacy of vitamin supplementation regimens exists. We compared the efficacy and tolerability of an investigational versus a standard multivitamin regimen in patients undergoing RYGB. METHODS: Fifty-six patients, aged 18 to 65, were randomized to an investigational versus a standard multivitamin. Plasma levels of vitamins A, B-12, D, E-α, E-β/γ, thiamine, folate, iron, iron-binding capacity, iron saturation, prealbumin, and parathyroid hormone (PTH) were measured at 3 and 6 months postoperatively...
March 2, 2018: Obesity Surgery
Lipeng Jing, Mianli Xiao, Hongli Dong, Jiesheng Lin, Gengdong Chen, Wenhua Ling, Yuming Chen
(1) Background: Carotenoids may be inversely associated with inflammatory markers (i.e., TNF-α, IL-6, IL-1β). However, data are scarce on retinol binding protein 4 (RBP4) in humans. We examined the associations among serum carotenoids, RBP4 and several inflammatory markers in a Chinese population. (2) Methods: This community-based cross-sectional study included 3031 participants (68% males) aged 40-75 years in Guangzhou, China. Serum concentrations of carotenoids, RBP4, and inflammatory markers were measured...
February 25, 2018: Nutrients
José M Alvarez-Suarez, Francesca Giampieri, Massimiliano Gasparrini, Luca Mazzoni, Tamara Y Forbes-Hernández, Sadia Afrin, Maurizio Battino
We analyzed guava fruits (Psidium guajava L. cv. Red Suprema) from Cuba to determine their chemical composition, total antioxidant capacity, as well as their protective effect against oxidative damage using an in vitro model of human dermal fibroblasts. The guava fruit is a natural source of bioactive compounds, such as polyphenols, vitamin C, folates and beta carotenes with proven health benefits. Human dermal fibroblasts were pre-incubated with different concentrations of guava crude extract and then subjected to oxidative stress using the AAPH stressor...
February 17, 2018: Plant Foods for Human Nutrition
H R Harris, A C Eke, J E Chavarro, S A Missmer
STUDY QUESTION: Is there an association between intake of fruits and vegetables and risk of laparoscopically confirmed endometriosis? SUMMARY ANSWER: Higher intake of fruits, particularly citrus fruits, is associated with a lower risk of endometriosis. WHAT IS KNOWN ALREADY: Two case-control studies have examined the associations between fruit and vegetable intake and endometriosis risk with contrasting results. Diets rich in fruits and vegetables include higher levels of pro-vitamin A nutrients (alpha-carotene, beta-carotene, beta-cryptoxanthin) and women with endometriosis have been reported to have lower intake of vitamin A than women without endometriosis...
February 1, 2018: Human Reproduction
Jiaqi Huang, Stephanie J Weinstein, Steven C Moore, Andriy Derkach, Xing Hua, Linda M Liao, Fangyi Gu, Alison M Mondul, Joshua N Sampson, Demetrius Albanes
Tobacco use, hypertension, hyperglycemia, overweight, and inactivity are leading causes of overall and cardiovascular disease (CVD) mortality worldwide, yet the relevant metabolic alterations responsible are largely unknown. We conducted a serum metabolomic analysis of 620 men in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (1985-2013). During 28 years of follow-up, there were 435 deaths (197 CVD and 107 cancer). The analysis included 406 known metabolites measured with ultra-high performance liquid chromatography/mass spectrometry-gas chromatography/mass spectrometry...
January 30, 2018: American Journal of Epidemiology
Maisarah Abdul Mutalib, Asmah Rahmat, Faisal Ali, Fauziah Othman, Rajesh Ramasamy
Background: This study aims to examine various solvent extracts of Cyphomandra betacea (tamarillo) also known as the tree tomato, for their bioactive constituents and antioxidant activity. The study also aims to examine its effect on cancer cell death using two types of cancer cell lines (liver and breast cancer cell). Methods: The first part of the study evaluates the nutritional composition of tamarillo. Then, phytochemical profiling using GC-MS analysis in ethanolic tamarillo extract was conducted...
October 2017: Malaysian Journal of Medical Sciences: MJMS
Jia-Rong Wu, Eun Kyeung Song, Debra K Moser, Terry A Lennie
BACKGROUND: Heart failure is a chronic, burdensome condition with higher re-hospitalization rates in African Americans than Whites. Higher dietary antioxidant intake is associated with lower oxidative stress and improved endothelial function. Lower dietary antioxidant intake in African Americans may play a role in the re-hospitalization disparity between African American and White patients with heart failure. OBJECTIVE: The objective of this study was to examine the associations among race, dietary antioxidant intake, and cardiac event-free survival in patients with heart failure...
January 1, 2018: European Journal of Cardiovascular Nursing
Nana Liu, Jing Chen, Dongmei Gao, Wenhua Li, Di Zheng
PURPOSE: The study was processed to investigate the effect of astaxanthin (AST; 3,3-dihydroxybeta, beta-carotene-4,4-dione) on the acute kidney injury induced by iohexol and the relationship with SIRT1/FOXO3a signal pathway. METHODS: Thirty male Sprague Dawley rats were randomly divided into five groups as follows: control group (CON; olive oil only), contrast media group, astaxanthin control group (100 mg/kg), low astaxanthin dose group (LAG, 50 mg/kg) and high astaxanthin dose group (HAG, 100 mg/kg)...
January 24, 2018: International Urology and Nephrology
Gabriela N Bosio, Julieta Parisi, Fernando S García Einschlag, Daniel O Mártire
In order to better understand the role of β-carotene and imidazole on the Photodynamic Therapy (PDT) mechanism, synchrotron infrared microscopy was used to detect the associated intracellular biochemical modifications following the visible light irradiation of HeLa cells incubated with these compounds as typical hydrophobic and hydrophilic singlet oxygen quenchers, respectively. For this purpose, PDT was performed employing the hydrophilic sensitizer 5,10,15,20-Tetrakis (1-methyl-4-pyridinio) porphyrin tetra (p-toluenesulfonate), TMPyP, and the hydrophobic sensitizer 5-(4-Methoxycarboxyphenyl)-10,15,20-triphenyl-21H,23H-porphyrin...
January 20, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Ashay Jain, Gajanand Sharma, Varun Kushwah, Gargi Ghoshal, Atul Jain, Bhupinder Singh, U S Shivhare, Sanyog Jain, O P Katare
Beta carotene (βC) loaded nanoparticles of zein (βC-NPs) were developed using modified phase separation technique. βC-NPs were prepared using different zein concentration and optimized formulation was selected on the basis of micromeritics properties and entrapment efficiency. Further, βC-NPs were evaluated for in vitro release, in vitro cell-survival, cellular localization and apoptosis induced in MCF-7 cells. The combined effect of the βC and its nanoparticulate counterpart with MTX was evaluated thereafter for cytotoxicity and apoptotic activity in MCF-7 cells...
January 23, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Batya Rinsky, Shira Hagbi-Levi, Sarah Elbaz-Hayoun, Michelle Grunin, Itay Chowers
Purpose: Oral vitamin and mineral supplements reduce the risk of visual loss in age-related macular degeneration (AMD). However, the pathways that mediate this beneficial effect are poorly understood. Macrophages may exert oxidative, inflammatory, and angiogenic effects in the context of AMD. We aim to assess if oral supplements can modulate the macrophage phenotype in this disease. Methods: Monocytes were isolated from patients with neovascular AMD (nvAMD), cultured, matured to macrophages, and polarized to classical [M1 (stimulated by IFNγ and lipopolysaccharide (LPS))] and alternative [M2 (stimulated with IL-4 and IL-13)] phenotypes...
2017: Molecular Vision
Sylwia Merkiel-Pawłowska, Wojciech Chalcarz
BACKGROUND: Nutrition in children has an important influence on health both in childhood and adulthood. Actions aimed at improving children's nutrition are essential, not only to the children and their families, but also to the whole society. The aim of the study was to present the results of nutrient intake before starting a nutrition and physical activity intervention programme, to investigate gender differences in nutrient intake and to discuss whether the preschoolers' nutrient intake is similar to the intake of their peers from other countries...
December 19, 2017: BMC Pediatrics
M Song, M C Camargo, S J Weinstein, G Murphy, N D Freedman, J Koshiol, R Z Stolzenberg-Solomon, C C Abnet, S Männistö, D Albanes, C S Rabkin
BACKGROUND: Serum pepsinogen 1 (SPG1) and anti-Helicobacter pylori serology have been used for gastric risk stratification in Asia. AIM: To assess utility of these markers in a Western population. METHODS: SPG1 measurements were available for 21 895 Finnish male smokers in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. We used Cox proportional hazards models adjusted for potential confounders to estimate gastric cancer hazard ratios (HR) and 95% confidence intervals (95% CI) for low SPG1 (<25 μg/L)...
February 2018: Alimentary Pharmacology & Therapeutics
Rahel Getu, Yetenayet B Tola, Satheesh Neela
BACKGROUND: Soy milk-based beverages play an important role as a healthy food alternative for human consumption. However, the ‘beany’ flavor and chalky mouth feel of soy milk often makes it unpalatable to consumers. The objective of the present study is to optimize a blend of soy milk, mango nectar and sucrose solution for the best quality soy milk-based beverage. METHODS: This study was designed to develop a soy milk blended beverage, with mango nectar and sucrose solutions, with the best physicochemical and sensory properties...
October 2017: Acta Scientiarum Polonorum. Technologia Alimentaria
Thao Thi Thu Nguyen, Hiromasa Tsujiguchi, Yasuhiro Kambayashi, Akinori Hara, Sakae Miyagi, Yohei Yamada, Haruki Nakamura, Yukari Shimizu, Daisuke Hori, Fumihiko Suzuki, Koichiro Hayashi, Hiroyuki Nakamura
Only a few studies have focused on the relationship between vitamin intake and depressive symptoms in Japanese individuals. This cross-sectional study investigated the relationship between vitamin intake and depressive symptoms in 1634 elderly Japanese individuals (65 years and older). The consumption of fifteen vitamins including retinol, a retinol equivalent, beta-carotene equivalent, vitamin D, alpha-tocopherol, vitamin K, vitamin group B, vitamin C, and cryptoxanthine was analyzed using a brief-type self-administered diet history questionnaire (BDHQ)...
December 3, 2017: Nutrients
Hanan Alfawaz, Nasiruddin Khan, Aziza Alfaifi, Fatima M Shahrani, Huda M Al Tameem, Seetah F Al Otaibi, Weaam I Abudigin, Mohammad S Al-Shayaa, Saad A Al-Ghanim, Nasser M Al-Daghri
BACKGROUND: The economic boom in Saudi Arabia indirectly prompted the use of dietary supplements in the last two decades. Our aim is to investigate the prevalence of dietary supplement use and its association with sociodemographic/lifestyle characteristics among Saudi female students. METHODS: In this cross-sectional study, 534 female participants (≥19 years of age) completed a self-administered questionnaire that include sociodemographic and lifestyle characteristics, perceived health status, dietary supplement use, general awareness, attitudes and behavior...
November 22, 2017: BMC Women's Health
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