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beta-carotene

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https://www.readbyqxmd.com/read/29751637/fast-profiling-of-natural-pigments-in-different-spirulina-arthrospira-platensis-dietary-supplements-by-di-ft-icr-and-evaluation-of-their-antioxidant-potential-by-pre-column-dpph-uhplc-assay
#1
Eduardo Sommella, Giulio Maria Conte, Emanuela Salviati, Giacomo Pepe, Alessia Bertamino, Carmine Ostacolo, Francesca Sansone, Francesco Del Prete, Rita Patrizia Aquino, Pietro Campiglia
Arthrospira platensis , better known as Spirulina, is one of the most important microalgae species. This cyanobacterium possesses a rich metabolite pattern, including high amounts of natural pigments. In this study, we applied a combined strategy based on Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FT-ICR-MS) and Ultra High-Performance Liquid Chromatography (UHPLC) for the qualitative/quantitative characterization of Spirulina pigments in three different commercial dietary supplements. FT-ICR was employed to elucidate the qualitative profile of Spirulina pigments, in both direct infusion mode (DIMS) and coupled to UHPLC...
May 11, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29743162/telomere-length-and-lung-cancer-mortality-among-heavy-smokers
#2
Jennifer A Doherty, Laurie Grieshober, John R Houck, Matthew J Barnett, Jean de Dieu Tapsoba, Mark Thornquist, Ching-Yun Wang, Gary E Goodman, Chu Chen
BACKGROUND: Accumulating evidence suggests that short telomere length is associated with increased overall mortality, but the relationship with cancer mortality is less clear. We examined whether telomere length (global, and chromosome arm 5p- and 13q-specific) is associated with lung cancer mortality among cases from the Beta Carotene and Retinol Efficacy Trial of heavy smokers. METHODS: Telomere length was measured on average six years before diagnosis for 788 lung cancer cases...
May 9, 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29713375/engineering-global-transcription-to-tune-lipophilic-properties-in-yarrowia-lipolytica
#3
Man Wang, Guan-Nan Liu, Hong Liu, Lu Zhang, Bing-Zhi Li, Xia Li, Duo Liu, Ying-Jin Yuan
Background: Evolution of complex phenotypes in cells requires simultaneously tuning expression of large amounts of genes, which can be achieved by reprograming global transcription. Lipophilicity is an important complex trait in oleaginous yeast Yarrowia lipolytica . It is necessary to explore the changes of which genes' expression levels will tune cellular lipophilic properties via the strategy of global transcription engineering. Results: We achieved a strategy of global transcription engineering in Y...
2018: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/29699655/emulsion-droplet-crystallinity-attenuates-early-in-vitro-digestive-lipolysis-and-beta-carotene-bioaccessibility
#4
Samantha M Hart, Xinjie Lois Lin, Surangi H Thilakarathna, Amanda J Wright
The impacts of lipid crystallinity on in vitro digestive lipolysis and bioaccessibility of encapsulated (0.1 wt%) beta-carotene (BC) were investigated for a 15 wt% cocoa butter emulsion prepared as crystalline (i.e. solid emulsions, SE & SE-BC) or undercooled (liquid emulsions, LE & LE-BC) droplets at 25 °C. Particle size distributions (D4,3 ∼0.7 μm), morphology (spherical), polymorphism (beta-V), thermal behavior (peak melting ∼30 °C), zeta potential (∼-44 mV) and BC degradation under accelerated lighting conditions were similarly extensive...
September 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29690623/plasma-and-salivary-non-urate-total-antioxidant-capacity-does-not-depend-on-dietary-vitamin-c-e-or-%C3%AE-carotene-intake-in-older-subjects
#5
Anna Gawron-Skarbek, Agnieszka Guligowska, Anna Prymont-Przymińska, Dariusz Nowak, Tomasz Kostka
The native Total Antioxidant Capacity (TAC) of plasma and saliva is generally determined by uric acid (UA). Several studies have assessed the impact of habitual dietary antioxidative vitamin intake on TAC, but it remains unknown whether it influences Non-Urate Total Antioxidant Capacity (Nu-TAC), i.e., TAC after enzymatic UA elimination. The purpose of this study was to assess whether the intake of antioxidative vitamins C, E, and β-carotene, provided with usual daily food rations, affects plasma and salivary Nu-TAC...
April 23, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29690612/neuroprotective-and-anti-inflammatory-effects-of-rhus-coriaria-extract-in-a-mouse-model-of-ischemic-optic-neuropathy
#6
Saba Khalilpour, Ghazaleh Behnammanesh, Fouad Suede, Mohammed O Ezzat, Jayadhisan Muniandy, Yasser Tabana, Mohamed Khadeer Ahamed, Ali Tamayol, Amin Malik Shah Majid, Enrico Sangiovanni, Mario Dell'Agli, Aman Shah Majid
Modulating oxidative stresses and inflammation can potentially prevent or alleviate the pathological conditions of diseases associated with the nervous system, including ischemic optic neuropathy. In this study we evaluated the anti-neuroinflammatory and neuroprotective activities of Rhus coriaria ( R. coriaria) extract in vivo. The half maximal inhibitory concentration (IC50 ) for DPPH, ABTS and β⁻carotene were 6.79 ± 0.009 µg/mL, 10.94 ± 0.09 µg/mL, and 6...
April 23, 2018: Biomedicines
https://www.readbyqxmd.com/read/29666392/synthetic-9-cis-beta-carotene-inhibits-photoreceptor-degeneration-in-cultures-of-eye-cups-from-rpe65rd12-mouse-model-of-retinoid-cycle-defect
#7
Ifat Sher, Adi Tzameret, Sara Peri-Chen, Victoria Edelshtain, Michael Ioffe, Alon Sayer, Ludmila Buzhansky, Ehud Gazit, Ygal Rotenstreich
The retinoid cycle enzymes regenerate the visual chromophore 11-cis retinal to enable vision. Mutations in the genes encoding the proteins of the retinoid cycle are the leading cause for recessively inherited retinal dystrophies such as retinitis pigmentosa, Leber congenital amaurosis, congenital cone-rod dystrophy and fundus albipunctatus. Currently there is no treatment for these blinding diseases. In previous studies we demonstrated that oral treatment with the 9-cis-β-carotene rich Dunaliella Bardawil algae powder significantly improved visual and retinal functions in patients with retinitis pigmentosa and fundus albipunctatus...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29662469/halotolerant-exiguobacterium-profundum-phm11-tolerate-salinity-by-accumulating-l-proline-and-fine-tuning-gene-expression-profiles-of-related-metabolic-pathways
#8
Vikas K Patel, Ruchi Srivastava, Anjney Sharma, Anchal K Srivastava, Savita Singh, Alok K Srivastava, Prem L Kashyap, Hillol Chakdar, K Pandiyan, Alok Kalra, Anil K Saxena
Salinity stress is one of the serious factors, limiting production of major agricultural crops; especially, in sodic soils. A number of approaches are being applied to mitigate the salt-induced adverse effects in agricultural crops through implying different halotolerant microbes. In this aspect, a halotolerant, Exiguobacterium profundum PHM11 was evaluated under eight different salinity regimes; 100, 250, 500, 1000, 1500, 2000, 2500, and 3000 mM to know its inherent salt tolerance limits and salt-induced consequences affecting its natural metabolism...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29642592/the-effects-of-long-term-low-and-high-dose-beta-carotene-treatment-in-zucker-diabetic-fatty-rats-the-role-of-ho-1
#9
Evelin Csepanyi, Attila Czompa, Peter Szabados-Furjesi, Istvan Lekli, Jozsef Balla, Gyorgy Balla, Arpad Tosaki, Istvan Bak
Nowadays, there is a growing interest in compounds derived from plants as potential raw materials for drug development. One of the most studied compounds is beta-carotene (BC). Several clinical studies can be found investigating the cardiovascular effects of BC, however, all these results are controversial. There is an increasing body of evidence showing that besides the well-known antioxidant properties, under strong oxidative circumstances, BC could become prooxidant as well. In this study, we investigated the effects of long-term, low- and high-dose BC treatment in ischemic/reperfused (ISA/REP) hearts isolated from Zucker diabetic fatty (ZDF) rats...
April 10, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29642428/consumption-of-100-pure-fruit-juice-and-dietary-quality-in-french-adults-analysis-of-a-nationally-representative-survey-in-the-context-of-the-who-recommended-limitation-of-free-sugars
#10
France Bellisle, Pascale Hébel, Alice Fourniret, Eléna Sauvage
Sugar-containing beverages are often seen as a negative influence on diet quality and body weight control. The present study examines the consumption of 100% fruit juice (FJ) based on a seven-day dietary survey in a representative sample of French adults ( n = 1607). About a half of the participants (44%) consumed FJ, most often at breakfast time (60%). Average intake in FJ consumers was 115.6 ± 4.0 mL/day (46.3 ± 1.7 kcal/day). Prevalence of consumption increased with education and income and decreased with age, but no association was observed with body mass index (BMI), physical activity, or smoking...
April 7, 2018: Nutrients
https://www.readbyqxmd.com/read/29619145/proper-controls-to-electrochemically-evaluate-carotenoids-using-%C3%AE-cyclodextrin-modified-surfaces
#11
Garrett Thompson, Sabrina Marnoto, Jeffrey M Halpern
We initially tested the electrochemical activity of beta-carotene and lutein at unmodified glassy carbon electrodes. We found good sensitivity (1 nA/μM) at high, micromolar concentrations, but serum levels are at nanomolar concentrations. To enhance the electrochemical activity, we modified the sensor surface with β-cyclodextrin, which has a hydrophobic core. Our goal was that the beta-carotene will be attracted to the β-cyclodextrin core, increasing surface interaction and sensitivity. Instead we saw a decrease in electrochemical activity...
October 2017: ECS Transactions
https://www.readbyqxmd.com/read/29617851/effects-of-nutrition-intervention-on-total-and-cancer-mortality-25-year-post-trial-follow-up-of-the-5-25-year-linxian-nutrition-intervention-trial
#12
Shao-Ming Wang, Philip R Taylor, Jin-Hu Fan, Ruth M Pfeiffer, Mitchell H Gail, He Liang, Gwen A Murphy, Sanford M Dawsey, You-Lin Qiao, Christian C Abnet
Background: A beneficial effect of supplementation with selenium, vitamin E, and beta-carotene was observed on total and cancer mortality in a Chinese population, and it endured for 10 years postintervention, but longer durability is unknown. Methods: A randomized, double-blind, placebo-controlled trial was conducted in Linxian, China, from 1986 to 1991; 29 584 residents age 40 to 69 years received daily supplementations based on a factorial design: Factors A (retinol/zinc), B (riboflavin/niacin), C (vitamin C/molybdenum), and/or D (selenium/vitamin E/beta-carotene), or placebo for 5...
April 3, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29608946/phytoestrogens-and-mycoestrogens-interacting-with-breast-cancer-proteins
#13
Diana Montes-Grajales, Esperanza Martínez-Romero, Jesus Olivero-Verbel
Breast cancer is a highly heterogeneous disease influenced by the hormonal microenvironment and the most common malignancy in women worldwide. Some phytoestrogens and mycoestrogens have been epidemiologically linked as risk factors or protectors, however their mechanisms of action are complex and not fully understood. The aim of this study was to predict the potential of 36 natural xenoestrogens to interact with 189 breast cancer proteins using AutoDock Vina. In order to validate our protocol, an in silico docking pose and binding site determination was compared with the crystallographic structure and the power of prediction to distinguish between ligand and decoys was evaluated though a receiver operating characteristic curve (ROC) of the resultant docking affinities and in vitro data...
March 30, 2018: Steroids
https://www.readbyqxmd.com/read/29580874/comparison-of-the-dietary-antioxidant-profiles-of-21-a-priori-defined-mediterranean-diet-indexes
#14
Angela Hernández-Ruiz, Belén García-Villanova, Eduardo Guerra-Hernández, Pilar Amiano, María-José Sánchez, Miren Dorronsoro, Esther Molina-Montes
BACKGROUND: The Mediterranean Diet (MD) is a dietary pattern that features a high quotient of antioxidant-rich foods. Differences in the level of dietary antioxidants intake reflected by different MD indexes has received little research attention. OBJECTIVE: The purpose of this study was to compare the dietary antioxidant profile of 21 a priori defined indexes of adherence to the MD. DESIGN: A cross-sectional study. PARTICIPANTS/SETTING: A total of 14,756 participants belonging to two Spanish European Prospective Investigation into Cancer and Nutrition cohorts, aged 32 to 69 years, recruited between 1992 and 1996, were included...
March 24, 2018: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/29551944/medically-important-carotenoids-from-momordica-charantia-and-their-gene-expressions-in-different-organs
#15
Do Manh Cuong, Mariadhas Valan Arasu, Jin Jeon, Yun Ji Park, Soon-Jae Kwon, Naif Abdullah Al-Dhabi, Sang Un Park
Carotenoids, found in the fruit and different organs of bitter melon ( Momordica charantia ), have attracted great attention for their potential health benefits in treating several major chronic diseases. Therefore, study related to the identification and quantification of the medically important carotenoid metabolites is highly important for the treatment of various disorderes. The present study involved in the identification and quantification of the various carotenoids present in the different organs of M...
December 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29521316/protective-effects-of-curcumin-and-beta-carotene-on-cisplatin-induced-cardiotoxicity-an-experimental-rat-model
#16
Anzel Bahadır, Ayşe Ceyhan, Özlem Öz Gergin, Betül Yalçın, Menekşe Ülger, Tuğçe Merve Özyazgan, Arzu Yay
OBJECTIVE: Cisplatin (CDDP) has been known to be an effective antineoplastic drug; however, it has a cardiotoxic effect. Curcumin (CMN) and beta-carotene (BC) have been suggested to protect biological systems against CDDP-induced damage. The current study was conducted to evaluate the possible protective roles of CMN and BC on CDDP-induced cardiotoxicity in rat cardiac tissues. METHODS: A total of 49 adult female Wistar albino rats were equally divided into seven groups as follows: control (no medication), sesame oil (1 mg/kg), CDDP (single dose injection two times as once a week, 5 mg/kg/week), BC (100 mg/kg), CDDP+BC (pretreated BC for 30 min before CDDP injection), CMN (200 mg/kg), and CDDP+CMN (pretreated CMN for 30 min before CDDP injection)...
March 2018: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/29517182/influence-of-selected-dietary-components-on-the-functioning-of-the-human-nervous-system
#17
Agnieszka Wendołowicz, Ewa Stefańska, Lucyna Ostrowska
The diet is directly connected not only with the physical status but also with the functioning of the brain and the mental status. The potentially beneficial nutrients with a protective effect on the nervous system function include amino acids (tryptophan, phenylalanine, tyrosine, taurine), glucose and vitamins C, E, D and beta-carotene, B group vitamins (vitamin B12, vitamin B6, vitamin B4, vitamin B1) and minerals (selenium, zinc, magnesium, sodium, iron, copper, manganese, iodine). The presence of antioxidants in the diet protects against oxidative damage to nervous system cells...
2018: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/29504274/nutrient-intake-in-women-before-conception-and-risks-of-anophthalmia-and-microphthalmia-in-their-offspring
#18
Kari A Weber, Wei Yang, Suzan L Carmichael, Gary M Shaw
BACKGROUND: We previously explored associations between nutrients including folate and other macro and micronutrients and risks of anophthalmia or microphthalmia in the National Birth Defects Prevention Study. In the current study, we expand those previous results with larger sample sizes and conduct analyses with an additional diet quality index using more recent data. METHODS: The National Birth Defects Prevention Study is a population-based, multicenter case-control study of over 30 major birth defects, with estimated due dates from October 1997 to December 2011...
March 5, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/29500675/a-randomized-trial-of-a-novel-chewable-multivitamin-and-mineral-supplement-following-roux-en-y-gastric-bypass
#19
Jamie Perin, Gregory Prokopowicz, Margaret Furtado, Konstantinos Papas, Kimberley E Steele
BACKGROUND: Vitamin and mineral deficiencies are common following Roux-en-Y gastric bypass (RYGB) and can lead to significant morbidity, but little research on the efficacy of vitamin supplementation regimens exists. We compared the efficacy and tolerability of an investigational versus a standard multivitamin regimen in patients undergoing RYGB. METHODS: Fifty-six patients, aged 18 to 65, were randomized to an investigational versus a standard multivitamin. Plasma levels of vitamins A, B-12, D, E-α, E-β/γ, thiamine, folate, iron, iron-binding capacity, iron saturation, prealbumin, and parathyroid hormone (PTH) were measured at 3 and 6 months postoperatively...
March 2, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29495330/serum-carotenoids-are-inversely-associated-with-rbp4-and-other-inflammatory-markers-in-middle-aged-and-elderly-adults
#20
Lipeng Jing, Mianli Xiao, Hongli Dong, Jiesheng Lin, Gengdong Chen, Wenhua Ling, Yuming Chen
(1) Background: Carotenoids may be inversely associated with inflammatory markers (i.e., TNF-α, IL-6, IL-1β). However, data are scarce on retinol binding protein 4 (RBP4) in humans. We examined the associations among serum carotenoids, RBP4 and several inflammatory markers in a Chinese population. (2) Methods: This community-based cross-sectional study included 3031 participants (68% males) aged 40-75 years in Guangzhou, China. Serum concentrations of carotenoids, RBP4, and inflammatory markers were measured...
February 25, 2018: Nutrients
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