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https://www.readbyqxmd.com/read/29259394/characterizing-the-effect-of-supplements-on-the-phenotype-of-cultured-macrophages-from-patients-with-age-related-macular-degeneration
#1
Batya Rinsky, Shira Hagbi-Levi, Sarah Elbaz-Hayoun, Michelle Grunin, Itay Chowers
Purpose: Oral vitamin and mineral supplements reduce the risk of visual loss in age-related macular degeneration (AMD). However, the pathways that mediate this beneficial effect are poorly understood. Macrophages may exert oxidative, inflammatory, and angiogenic effects in the context of AMD. We aim to assess if oral supplements can modulate the macrophage phenotype in this disease. Methods: Monocytes were isolated from patients with neovascular AMD (nvAMD), cultured, matured to macrophages, and polarized to classical [M1 (stimulated by IFNγ and lipopolysaccharide (LPS))] and alternative [M2 (stimulated with IL-4 and IL-13)] phenotypes...
2017: Molecular Vision
https://www.readbyqxmd.com/read/29258537/gender-differences-and-typical-nutrition-concerns-of-the-diets-of-preschool-children-the-results-of-the-first-stage-of-an-intervention-study
#2
Sylwia Merkiel-Pawłowska, Wojciech Chalcarz
BACKGROUND: Nutrition in children has an important influence on health both in childhood and adulthood. Actions aimed at improving children's nutrition are essential, not only to the children and their families, but also to the whole society. The aim of the study was to present the results of nutrient intake before starting a nutrition and physical activity intervention programme, to investigate gender differences in nutrient intake and to discuss whether the preschoolers' nutrient intake is similar to the intake of their peers from other countries...
December 19, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/29243850/serum-pepsinogen-1-and-anti-helicobacter-pylori-igg-antibodies-as-predictors-of-gastric-cancer-risk-in-finnish-males
#3
M Song, M C Camargo, S J Weinstein, G Murphy, N D Freedman, J Koshiol, R Z Stolzenberg-Solomon, C C Abnet, S Männistö, D Albanes, C S Rabkin
BACKGROUND: Serum pepsinogen 1 (SPG1) and anti-Helicobacter pylori serology have been used for gastric risk stratification in Asia. AIM: To assess utility of these markers in a Western population. METHODS: SPG1 measurements were available for 21 895 Finnish male smokers in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. We used Cox proportional hazards models adjusted for potential confounders to estimate gastric cancer hazard ratios (HR) and 95% confidence intervals (95% CI) for low SPG1 (<25 μg/L)...
December 15, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29241317/optimization-of-soymilk-mango-nectar-and-sucrose-solution-mixes-for-better-quality-of-soymilk-based-beverage
#4
Rahel Getu, Yetenayet B Tola, Satheesh Neela
BACKGROUND: Soy milk-based beverages play an important role as a healthy food alternative for human consumption. However, the ‘beany’ flavor and chalky mouth feel of soy milk often makes it unpalatable to consumers. The objective of the present study is to optimize a blend of soy milk, mango nectar and sucrose solution for the best quality soy milk-based beverage. METHODS: This study was designed to develop a soy milk blended beverage, with mango nectar and sucrose solutions, with the best physicochemical and sensory properties...
October 2017: Acta Scientiarum Polonorum. Technologia Alimentaria
https://www.readbyqxmd.com/read/29207502/relationship-between-vitamin-intake-and-depressive-symptoms-in-elderly-japanese-individuals-differences-with-gender-and-body-mass-index
#5
Thao Thi Thu Nguyen, Hiromasa Tsujiguchi, Yasuhiro Kambayashi, Akinori Hara, Sakae Miyagi, Yohei Yamada, Haruki Nakamura, Yukari Shimizu, Daisuke Hori, Fumihiko Suzuki, Koichiro Hayashi, Hiroyuki Nakamura
Only a few studies have focused on the relationship between vitamin intake and depressive symptoms in Japanese individuals. This cross-sectional study investigated the relationship between vitamin intake and depressive symptoms in 1634 elderly Japanese individuals (65 years and older). The consumption of fifteen vitamins including retinol, a retinol equivalent, beta-carotene equivalent, vitamin D, alpha-tocopherol, vitamin K, vitamin group B, vitamin C, and cryptoxanthine was analyzed using a brief-type self-administered diet history questionnaire (BDHQ)...
December 3, 2017: Nutrients
https://www.readbyqxmd.com/read/29166929/prevalence-of-dietary-supplement-use-and-associated-factors-among-female-college-students-in-saudi-arabia
#6
Hanan Alfawaz, Nasiruddin Khan, Aziza Alfaifi, Fatima M Shahrani, Huda M Al Tameem, Seetah F Al Otaibi, Weaam I Abudigin, Mohammad S Al-Shayaa, Saad A Al-Ghanim, Nasser M Al-Daghri
BACKGROUND: The economic boom in Saudi Arabia indirectly prompted the use of dietary supplements in the last two decades. Our aim is to investigate the prevalence of dietary supplement use and its association with sociodemographic/lifestyle characteristics among Saudi female students. METHODS: In this cross-sectional study, 534 female participants (≥19 years of age) completed a self-administered questionnaire that include sociodemographic and lifestyle characteristics, perceived health status, dietary supplement use, general awareness, attitudes and behavior...
November 22, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/29153456/association-of-mortality-with-ocular-diseases-and-visual-impairment-in-the-age-related-eye-disease-study-2-age-related-eye-disease-study-2-report-number-13
#7
Chandana Papudesu, Traci E Clemons, Elvira Agrón, Emily Y Chew
PURPOSE: To evaluate the association of mortality with visual acuity (VA) impairment, age-related macular degeneration (AMD), and cataract surgery. DESIGN: Cohort study. PARTICIPANTS: Participants with at least intermediate AMD enrolled in a randomized controlled clinical trial of lutein/zeaxanthin and/or omega-3 fatty acids, the Age-Related Eye Disease Study 2 (AREDS2), for treatment of AMD and cataract. METHODS: Baseline and annual eye examinations included best-corrected visual acuity (BCVA) assessments, slit-lamp examinations, and stereoscopic fundus photographs that were centrally graded for development of late AMD (central geographic atrophy or neovascular AMD) or pseudophakia...
November 16, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29075031/limited-evidence-for-interventions-to-treat-oral-leukoplakia
#8
Silvia Spivakovsky
Data sourcesCochrane Oral Health's Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), Medline Ovid, Embase, Ovid, CancerLit via PubMed. MetaRegister of Controlled Trials, ClinicalTrials.gov and the WHO International Clinical Trials Registry Platform were searched for ongoing trials.The reference lists of included studies and existing reviews were manually searched.Study selectionRandomised control trials (RCTs) including patients diagnosed with oral leukoplakia comparing any treatment to placebo or no treatment were included with no restrictions on language or date of publication...
October 27, 2017: Evidence-based Dentistry
https://www.readbyqxmd.com/read/29074648/draft-nuclear-genome-sequence-of-the-halophilic-and-beta-carotene-accumulating-green-alga-dunaliella-salina-strain-ccap19-18
#9
Juergen E W Polle, Kerrie Barry, John Cushman, Jeremy Schmutz, Duc Tran, Leyla T Hathwaik, Won C Yim, Jerry Jenkins, Zaid McKie-Krisberg, Simon Prochnik, Erika Lindquist, Rhyan B Dockter, Catherine Adam, Henrik Molina, Jakob Bunkenborg, EonSeon Jin, Mark Buchheim, Jon Magnuson
The halotolerant alga Dunaliella salina is a model for stress tolerance and is used commercially for production of beta-carotene (=pro-vitamin A). The presented draft genome of the genuine strain CCAP19/18 will allow investigations into metabolic processes involved in regulation of stress responses, including carotenogenesis and adaptations to life in high-salinity environments.
October 26, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29050286/a-prospective-study-of-serum-metabolites-and-glioma-risk
#10
Jiaqi Huang, Stephanie J Weinstein, Cari M Kitahara, Edward D Karoly, Joshua N Sampson, Demetrius Albanes
Malignant glioma is one of the most lethal adult cancers, yet its etiology remains largely unknown. We conducted a prospective serum metabolomic analysis of glioma based on 64 cases and 64 matched controls selected from Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study. Median time from collection of baseline fasting serum to diagnosis was nine years (inter-decile range 3-20 years). LC/MS-MS identified 730 known metabolites, and conditional logistic regression models estimated odds ratios for one-standard deviation differences in log-metabolite signals...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29016195/critical-assessment-of-analytical-techniques-in-the-search-for-biomarkers-on-mars-a-mummified-microbial-mat-from-antarctica-as-a-best-case-scenario
#11
Yolanda Blanco, Ignacio Gallardo-Carreño, Marta Ruiz-Bermejo, Fernando Puente-Sánchez, Erika Cavalcante-Silva, Antonio Quesada, Olga Prieto-Ballesteros, Víctor Parro
The search for biomarkers of present or past life is one of the major challenges for in situ planetary exploration. Multiple constraints limit the performance and sensitivity of remote in situ instrumentation. In addition, the structure, chemical, and mineralogical composition of the sample may complicate the analysis and interpretation of the results. The aim of this work is to highlight the main constraints, performance, and complementarity of several techniques that have already been implemented or are planned to be implemented on Mars for detection of organic and molecular biomarkers on a best-case sample scenario...
October 2017: Astrobiology
https://www.readbyqxmd.com/read/28989861/tackling-vitamin-a-deficiency-with-biofortified-sweetpotato-in-sub-saharan-africa
#12
REVIEW
Jan W Low, Robert O M Mwanga, Maria Andrade, Edward Carey, Anna-Marie Ball
Orange-fleshed sweetpotato (OFSP) is a rich plant-based source of beta-carotene, which the body converts into vitamin A. In sub-Saharan Africa, sweetpotato is known as a food security crop but most varieties grown are high dry matter white-fleshed types, lacking beta-carotene. In 1995, researchers recognized the potential of OFSP varieties to address widespread vitamin A deficiency in SSA using an integrated agriculture-nutrition approach. With their partners, they confronted conventional wisdom concerning food-based approaches and institutional barriers, to build the evidence base and breed 42 OFSP varieties adapted to farmer needs and consumer preferences...
September 2017: Global Food Security
https://www.readbyqxmd.com/read/28983399/carotenoids-as-potential-antioxidant-agents-in-stroke-prevention-a-systematic-review
#13
REVIEW
Ahmad Bahonar, Mohammad Saadatnia, Fariborz Khorvash, Mohammadreza Maracy, Alireza Khosravi
Stroke and other cerebrovascular diseases are among the most common causes of death worldwide. Prevention of modifiable risk factors is a cost-effective approach to decrease the risk of stroke. Oxidative stress is regarded as the major flexible operative agent in ischemic brain damage. This review presents recent scientific advances in understanding the role of carotenoids as antioxidants in lowering stroke risk based on observational studies. We searched Medline using the following terms: (Carotenoids [MeSH] OR Carotenes [tiab] OR Carotene [tiab] OR "lycopene [Supplementary Concept]" [MeSH] OR lycopene [tiab] OR beta-Carotene [tiab]) AND (stroke [MeSH] OR stroke [tiab] OR "Cerebrovascular Accident" [tiab] OR "Cerebrovascular Apoplexy" [tiab] OR "Brain Vascular Accident" [tiab] OR "Cerebrovascular Stroke" [tiab]) AND ("oxidative stress" [MeSH] OR "oxidative stress"[tiab])...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28963040/beta-carotene-as-a-novel-therapy-for-the-treatment-of-autistic-like-behavior-in-animal-models-of-autism
#14
Yosefa Avraham, Elliot M Berry, Marina Donskoy, Wiessam Abu Ahmad, Lia Vorobiev, Amnon Albeck, David Mankuta
Autism-affected individuals are characterized by lower plasma oxytocin and its ectoenzyme regulator CD38. Oxytocin, a hypothalamic hormone secreted upon the release of CD38, plays a role in social behavior and bonding. All-trans retinoic acid is a potent inducer of CD38 and can be used as a novel therapeutic strategy in autism. We investigated the role of beta-carotene in rescuing autistic-like behavior in BALB/c and BTBR mice. Beta-carotene derivatives are preferred as they are neither toxic nor teratogenic...
September 28, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28919902/expression-differences-of-pigment-structural-genes-and-transcription-factors-explain-flesh-coloration-in-three-contrasting-kiwifruit-cultivars
#15
Yanfei Liu, Bin Zhou, Yingwei Qi, Xin Chen, Cuihua Liu, Zhande Liu, Xiaolin Ren
Fruits of kiwifruit cultivars (Actinidia chinensis and A. deliciosa) generally have green or yellow flesh when ripe. A small number of genotypes have red flesh but this coloration is usually restricted to the inner pericarp. Three kiwifruit cultivars having red ('Hongyang'), or yellow ('Jinnong-2'), or green ('Hayward') flesh were investigated for their color characteristics and pigment contents during development and ripening. The results show the yellow of the 'Jinnong-2' fruit is due to the combined effects of chlorophyll degradation and of beta-carotene accumulation...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28888617/relationships-between-bone-mass-and-dietary-lifestyle-habits-in-japanese-women-at-3-4-months-postpartum
#16
A Hoshino, A Yamada, R Tanabe, S Noda, K Nakaoka, Y Oku, C Katayama, M Haraikawa, H Nakano, M Harada, K Uenishi, M Goseki-Sone
OBJECTIVES: The relationships between calcaneal bone mass and dietary/lifestyle habits in women at 3-4 months postpartum were examined in the context of osteoporosis prevention. STUDY DESIGN: Cross-sectional survey. METHODS: We measured bone mass using calcaneal ultrasound in mothers who brought their 3- to 4-month-old babies to healthcare centers in Japan for health examination and administered a self-report questionnaire on physical characteristics and dietary/lifestyle habits to those who agreed to participate in the survey...
September 7, 2017: Public Health
https://www.readbyqxmd.com/read/28878287/metabolomic-profiling-of-serum-retinol-in-the-alpha-tocopherol-beta-carotene-cancer-prevention-atbc-study
#17
Jiaqi Huang, Orestis A Panagiotou, Gabriella M Anic, Alison M Mondul, Linda M Liao, Andriy Derkach, Rachael Stolzenberg-Solomon, Stephanie J Weinstein, Demetrius Albanes
The role of retinol in the prevention of multifactorial chronic diseases remains uncertain, and there is sparse evidence regarding biological actions and pathways implicated in its effects on various outcomes. The aim is to investigate whether serum retinol in an un-supplemented state is associated with low molecular weight circulating metabolites. We performed a metabolomic analysis of 1,282 male smoker participants based on pre-supplementation fasting serum in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28869773/antioxidant-consumption-is-associated-with-decreased-odds-of-congenital-limb-deficiencies
#18
Nelson D Pace, Tania A Desrosiers, Suzan L Carmichael, Gary M Shaw, Andrew F Olshan, Anna Maria Siega-Riz
BACKGROUND: Approximately 1 in 2000 infants is born with a limb deficiency in the US. Research has shown that women's periconceptional diet and use of vitamin supplements can affect risk of birth defects. We investigated whether maternal consumption of nutritional antioxidants was associated with occurrence of transverse limb deficiency (TLD) and longitudinal limb deficiencies (LLD). METHODS: We analysed case-control data from mothers and their singleton infants with TLD (n = 566), LLD (n = 339), or no malformation (controls; n = 9384) in the National Birth Defects Prevention Study (1997-2009)...
September 4, 2017: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/28867793/diet-gut-microbiome-and-epigenetics-emerging-links-with-inflammatory-bowel-diseases-and-prospects-for-management-and-prevention
#19
REVIEW
Krasimira Aleksandrova, Beatriz Romero-Mosquera, Vicent Hernandez
Inflammatory bowel diseases (IBD) represent a growing public health concern due to increasing incidence worldwide. The current notion on the pathogenesis of IBD is that genetically susceptible individuals develop intolerance to dysregulated gut microflora (dysbiosis) and chronic inflammation develops as a result of environmental triggers. Among the environmental factors associated with IBD, diet plays an important role in modulating the gut microbiome, influencing epigenetic changes, and, therefore, could be applied as a therapeutic tool to improve the disease course...
August 30, 2017: Nutrients
https://www.readbyqxmd.com/read/28821981/modifiable-factors-and-esophageal-cancer-a-systematic-review-of-published-meta-analyses
#20
REVIEW
Clara Castro, Bárbara Peleteiro, Nuno Lunet
There are marked differences in the etiology of the major histological types of esophageal cancer (EC)-squamous cell carcinomas (ESCC) and adenocarcinomas (EAC). This study aimed to summarize the current scientific knowledge on modifiable risk factors for EC, by histological type, through a systematic review of meta-analyses referenced in PubMed and ISI Web of Knowledge. We identified 100 meta-analyses on risk factors for ESCC (n = 54), EAC (n = 43), or EC (n = 51). ESCC risk significantly increased with alcohol and maté drinking, smoking, red and processed meat consumption and human papillomavirus infection, while it was negatively associated with body mass index and consumption of fruit, vegetables, white meat, folate, and some carotenoids...
August 18, 2017: Journal of Gastroenterology
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