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https://www.readbyqxmd.com/read/28703643/methotrexate-and-beta-carotene-loaded-lipid-polymer-hybrid-nanoparticles-a-preclinical-study-for-breast-cancer
#1
Ashay Jain, Gajanand Sharma, Varun Kushwah, Neeraj K Garg, Prashant Kesharwani, Gargi Ghoshal, Bhupinder Singh, Uma Shankar Shivhare, Sanyog Jain, Om Prakash Katare
AIM: This work was intended to investigate the targeting potential of fructose-tethered lipid-polymeric hybrid nanoparticles (F-BC-MTX-LPHNPs) co-loaded with beta carotene (BC) and methotrexate (MTX) in breast cancer therapeutics and find out the possible protective role of BC on MTX-induced toxicity. MATERIALS & METHODS: F-BC-MTX-LPHNPs were fabricated using self-assembled nano-precipitation technique. Fructose was conjugated on the surface of the particles. The in vitro cytotoxicity, sub-cellular localization and apoptotic activity of F-BC-MTX-LPHNPs were evaluated against MCF-7 breast cancer cells...
July 13, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28698186/serum-insulin-glucose-indices-of-insulin-resistance-and-risk-of-lung-cancer
#2
Ilona Argirion, Stephanie J Weinstein, Satu Männistö, Demetrius Albanes, Alison M Mondul
BACKGROUND: Although insulin may increase risk of some cancers, few studies have examined fasting serum insulin and lung cancer risk. METHODS: We examined serum insulin, glucose, and indices of insulin resistance (insulin:glucose molar ratio and homeostasis model assessment of insulin resistance [HOMA-IR]) and lung cancer risk using a case-cohort study within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Studyof Finnish men. 196 cases and 395 subcohort members were included...
July 11, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28696684/development-of-beta-carotene-loaded-organogel-based-nanoemulsion-with-improved-in-vitro-and-in-vivo-bioaccessibility
#3
Yuting Fan, Luyu Gao, Jiang Yi, Yuzhu Zhang, Wallace Yokoyama
Beta-carotene (BC), a naturally occurring lipophilic carotenoid, is beneficial for human health. However, its water solubility and bioavailability is low. In this study, organogel-based nanoemulsion was successfully prepared to improve BC's loading amount, solubility, and bioavailability. Corn oil was selected as oil phase for organogel due to the greatest release amount of BC. Tween 20 was optimized as the emulsifier based on the highest extent of lipolysis and BC bioaccessibility. The nanoemulsion was a better alternative than organogel according to both the extent of lipolysis and BC bioaccessibility...
July 11, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28663343/fine-mapping-transcriptome-analysis-and-marker-development-for-y2-the-gene-that-conditions-beta-carotene-accumulation-in-carrot-daucus-carota-l
#4
Shelby Ellison, Douglas Senalik, Hamed Bostan, Massimo Iorizzo, Philipp Simon
Domesticated carrots, Daucus carota subsp. sativus, are the richest source of beta-carotene in the US diet, which when consumed is converted into vitamin A, an essential component of eye health and immunity. The Y2 locus plays a significant role in beta-carotene accumulation in carrot roots, but a candidate gene has not been identified. To advance our understanding of this locus, the genetic basis of beta-carotene accumulation was explored by utilizing an advanced mapping population, transcriptome analysis, and nucleotide diversity in diverse carrot accessions with varying levels of beta-carotene...
June 29, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28653475/amylosucrase-mediated-%C3%AE-carotene-encapsulation-in-amylose-microparticles
#5
Carlos Andres Morales Letona, Cheon-Seok Park, Young-Rok Kim
The beta-carotene embedded amylose microparticles (BC-AmMPs) were prepared in one-step by utilizing the unique catalytic activity of amylosucrase from Deinococcus geothermalis (DgAS), which synthesizes linear amylose chains using sucrose as the sole substrate. Synthesized amylose chains self-assembled with beta carotene to form well-defined spherical microparticles with an encapsulation yield of 65%. The BC-AmMPs produced (average diameter ∼8 µm) were bright orange due to the embedded beta-carotene, and this was confirmed by Raman analysis...
June 27, 2017: Biotechnology Progress
https://www.readbyqxmd.com/read/28625776/beta-carotene-preferentially-regulates-chicken-myoblast-proliferation-withdrawal-and-differentiation-commitment-via-bco1-activity-and-retinoic-acid-production
#6
C Praud, S Al Ahmadieh, E Voldoire, Y Le Vern, E Godet, N Couroussé, B Graulet, E Le Bihan Duval, C Berri, M J Duclos
The enzyme β-carotene oxygenase 1 (BCO1) catalyzes the breakdown of provitamin A, including beta-carotene (BC), into retinal, prior to its oxidation into retinoic acid (RA). Allelic variation at the BCO1 locus results in differential expression of its mRNA and affects carotenoid metabolism specifically in chicken Pectoralis major muscle. In this context, the aim of this study was to evaluate the potential myogenic effect of BC and the underlying mechanisms in chicken myoblasts. BCO1 mRNA was detected in myoblasts derived from chicken satellite cells...
June 15, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28568053/low-vitamin-b12-increases-risk-of-gastric-cancer-a-prospective-study-of-one-carbon-metabolism-nutrients-and-risk-of-upper-gastrointestinal-tract-cancer
#7
Eugenia H Miranti, Rachael Stolzenberg-Solomon, Stephanie J Weinstein, Jacob Selhub, Satu Männistö, Philip R Taylor, Neal D Freedman, Demetrius Albanes, Christian C Abnet, Gwen Murphy
Previous studies have found associations between one-carbon metabolism nutrients and risk of several cancers, but little is known regarding upper gastrointestinal tract (UGI) cancer. We analyzed prediagnostic serum concentrations of several one-carbon metabolism nutrients (vitamin B12, folate, vitamin B6, riboflavin and homocysteine) in a nested case-control study within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study of male smokers, which was undertaken in Finland between 1985 and 1988...
May 31, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28554634/valorization-of-dacryodes-rostrata-fruit-through-the-characterization-of-its-oil
#8
Lee Hong Tee, Bao Yang, Beng Ti Tey, Eng-Seng Chan, Azrina Azlan, Amin Ismail, Jian Sun, Cheng Yuon Lau, Uma D Palanisamy, Ramakrishnan Nagasundara Ramanan, Krishnamurthy Nagendra Prasad
Dacryodes rostrata (kembayau) is an important food and oil resource for local communities in Borneo, but it is not commonly known to wider community. The objective of this work is to valorize kembayau fruit by evaluating the characteristics of the oil from the fruit. In this study, the physicochemical characteristics and the lipophilic essential nutrient; the fatty acid composition, vitamin E and beta-carotene content of oils obtained from the peel, pulp and seeds of kembayau fruits were studied. The pulp of the kembayau fruit contained highest proportion of oil, followed by peel and seed...
November 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28552108/pistacia-chinensis-strong-antioxidant-and-potent-testicular-toxicity-amelioration-agent
#9
Farah Noureen, Muhammad Rashid Khan, Naseer Ali Shah, Rahmat Ali Khan, Kiran Naz, Saadia Sattar
OBJECTIVES: To evaluate in vitro and in vivo antioxidant potency of Pistacia chinensis (P. chinensis) bark and leaves extracts along with its protective role against CCl4 induced toxicity in testis of the rat. METHODS: Various in vitro models such as DPPH, ABTS, hydrogen peroxide, superoxide, hydroxyl and nitric oxide scavenging activities, anti-lipid peroxidation activity, phospho-molybdenum activity, β carotene bleaching assay was used for analysis of antioxidant potential...
April 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28542353/identification-of-cow-and-buffalo-milk-based-on-beta-carotene-and-vitamin-a-concentration-using-fluorescence-spectroscopy
#10
Rahat Ullah, Saranjam Khan, Hina Ali, Muhammad Bilal, Muhammad Saleem
The current study presents the application of fluorescence spectroscopy for the identification of cow and buffalo milk based on β-carotene and vitamin-A which is of prime importance from the nutritional point of view. All samples were collected from healthy animals of different breeds at the time of lactation in the vicinity of Islamabad, Pakistan. Cow and buffalo milk shows differences at fluorescence emission appeared at band position 382 nm, 440 nm, 505 nm and 525 nm both in classical geometry (right angle) setup as well as front face fluorescence setup...
2017: PloS One
https://www.readbyqxmd.com/read/28539965/chemicals-compositions-antioxidant-and-anti-inflammatory-activity-of-cynara-scolymus-leaves-extracts-and-analysis-of-major-bioactive-polyphenols-by-hplc
#11
Maryem Ben Salem, Hanen Affes, Khaled Athmouni, Kamilia Ksouda, Raouia Dhouibi, Zouheir Sahnoun, Serria Hammami, Khaled Mounir Zeghal
Objective. Artichoke (Cynara scolymus L.) was one of the plant remedies for primary health care. The present study was focused on the determination of chemical composition, antioxidant activities, and anti-inflammatory activity and on analyzing its major bioactive polyphenols by HPLC. Methods. Artichoke Leaves Extracts (ALE) were analyzed for proximate analysis and phytochemical and antioxidant activity by several methods such as DDPH, ABTS, FRAP, and beta-carotene bleaching test. The carrageenan (Carr) model induced paw oedema in order to investigate the anti-inflammatory activity...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28531132/effects-of-%C3%AE-carotene-and-its-cleavage-products-in-primary-pneumocyte-type-ii-cells
#12
Cornelia Haider, Franziska Ferk, Ekramije Bojaxhi, Giuseppe Martano, Hanno Stutz, Nikolaus Bresgen, Siegfried Knasmüller, Avdulla Alija, Peter M Eckl
β-Carotene has been shown to increase the risk of developing lung cancer in smokers and asbestos workers in two large scale trails, the Beta-Carotene and Retinol Efficacy Trial (CARET) and the Alpha-Tocopherol Beta-carotene Cancer Prevention Trial (ATBC). Based on this observation, it was proposed that genotoxic oxidative breakdown products may cause this effect. In support of this assumption, increased levels of sister chromatid exchanges, micronuclei, and chromosomal aberrations were found in primary hepatocyte cultures treated with a mixture of cleavage products (CPs) and the major product apo-8'carotenal...
May 21, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28529085/variations-in-native-protein-glycation-and-plasma-antioxidants-in-several-birds-of-prey
#13
Tana Ingram, Jessica Zuck, Chad R Borges, Patrick Redig, Karen L Sweazea
Birds are an anomaly among vertebrates as they are remarkably long-lived despite having naturally high blood glucose and metabolic rates. For mammals, hyperglycemia leads to oxidative stress and protein glycation. In contrast, many studies have shown that domestic and wild birds are relatively resistant to these glucose-mediated pathologies. Surprisingly very little research has examined protein glycation in birds of prey, which by nature consume a diet high in protein and fat that promotes gluconeogenesis...
August 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28448568/inhibitory-effects-of-fenretinide-metabolites-n-4-methoxyphenyl-retinamide-mpr-and-4-oxo-n-4-hydroxyphenyl-retinamide-3-keto-hpr-on-fenretinide-molecular-targets-%C3%AE-carotene-oxygenase-1-stearoyl-coa-desaturase-1-and-dihydroceramide-%C3%AE-4-desaturase-1
#14
Eugenia Poliakov, William Samuel, Todd Duncan, Danielle B Gutierrez, Nathan L Mata, T Michael Redmond
The therapeutic capacity of fenretinide (N-[4-hydroxyphenyl] retinamide; 4-HPR) has been demonstrated for several conditions, including cancer, obesity, diabetes, and ocular disease. Yet, the mechanisms of action for its pleiotropic effects are still undefined. We hypothesized that investigation of two of the major physiological metabolites of fenretinide, N-[4-methoxyphenyl]retinamide (MPR) and 4-oxo-N-(4-hydroxyphenyl)retinamide (3-keto-HPR), might begin to resolve the multifaceted effects of this synthetic retinoid...
2017: PloS One
https://www.readbyqxmd.com/read/28415031/carotenoid-accumulation-in-durian-durio-zibethinus-fruit-is-affected-by-ethylene-via-modulation-of-carotenoid-pathway-gene-expression
#15
Apinya Wisutiamonkul, Charles Ampomah-Dwamena, Andrew C Allan, Saichol Ketsa
Carotenoid content in durian (Durio zibethinus) fruit is an important aspect of fruit quality, with different cultivars distinguished by differing pigmentation. We have studied the dependence of carotenogenesis on ethylene. Fruit of the cultivar 'Chanee' harvested at the mature stage were either left untreated (controls), treated with 1-methylcyclopropene (1-MCP) for 12 h, or treated with application of an aqueous ethephon solution to the stem end, or treated for 12 h with 1-MCP followed by ethephon application...
June 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28391446/a-review-of-current-and-future-management-of-geographic-atrophy
#16
REVIEW
Riccardo Sacconi, Eleonora Corbelli, Lea Querques, Francesco Bandello, Giuseppe Querques
Age-related macular degeneration (AMD) is a multifactorial disease and a leading cause of vision impairment in elderly people in Western society. Geographic atrophy (GA), the late stage of dry AMD, is typically defined as a round or oval area of atrophy of 175 µm or more. In GA patients, visual acuity (VA) can still be good if the macula is spared, but decreased if GA extends through the fovea causing a great impairment of quality of life. Because of a poor correlation between VA and GA lesions or progression, a multimodal imaging approach is necessary to better follow up GA patients...
June 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28387444/comparative-modulation-of-levels-of-oxidative-stress-in-the-liver-of-anti-tuberculosis-drug-treated-wistar-rats-by-vitamin-b12-beta-carotene-and-spirulina-fusiformis-role-of-nf-kb-inos-il-6-and-il-10
#17
Sherry Joseph Martin, Evan Prince Sabina
PURPOSE: Isoniazid (INH) and Rifampicin (RIF) are known hepatotoxic agents. We compared the efficacy of Spirulina fusiformis and its active components vitamin B12 and beta-carotene in attenuating INH & RIF induced hepatotoxicity. We also tried to elucidate the inflammatory mechanism behind anti-tuberculosis drug induced hepatotoxicity. METHODS: INH & RIF were administered to Wistar albino rats for 28 days to induce hepatotoxicity. Spirulina fusiformis, vitamin B12 and beta-carotene were co-administered with INH & RIF and their hepatoprotective, antioxidant and immunomodulatory roles were studied through blood and liver analysis...
April 7, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28369403/serum-gastrin-and-cholecystokinin-are-associated-with-subsequent-development-of-gastric-cancer-in-a-prospective-cohort-of-finnish-smokers
#18
Gwen Murphy, Christian C Abnet, Hyoyoung Choo-Wosoba, Emily Vogtmann, Stephanie J Weinstein, Philip R Taylor, Satu Männistö, Demetrius Albanes, Sanford M Dawsey, Jens F Rehfeld, Neal D Freedman
Background: Gastrin, which induces gastric acid secretion, and a structurally similar hormone, cholecystokinin (CCK)-a potent acid inhibitor, may each play a role in gastric cancer. However, few studies have investigated this hypothesis in humans. We therefore investigated whether serum gastrin or CCK concentrations at baseline were associated with the incidence of gastric non-cardia adenocarcinomas (GNCA), oesophagogastric junctional adenocarcinomas (EGJA) or gastric carcinoid tumours over 24 years of follow-up in a study nested within the all-male Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study of Finnish smokers...
March 27, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28345698/ethylcellulose-oleogels-for-lipophilic-bioactive-delivery-effect-of-oleogelation-on-in-vitro-bioaccessibility-and-stability-of-beta-carotene
#19
Chloe M O Sullivan, Maya Davidovich-Pinhas, Amanda J Wright, Shai Barbut, Alejandro G Marangoni
The in vitro lipolysis and β-carotene (BC) transfer from oil to aqueous phase of canola oil ethylcellulose (EC) oleogels were measured using a static monocompartmental model simulating oral, gastric, and duodenal digestive stages. The effects of EC oleogelation on gel in vitro digestibility were examined, using un-structured canola oil as a control. The physicochemical properties of oleogels containing BC were also measured. It was found that oleogels made with 10% 10 cP and 10% 20 cP did not differ significantly in their extent of lipolysis or BC transfer compared to canola oil; however 10% 45 cP and 15...
April 19, 2017: Food & Function
https://www.readbyqxmd.com/read/28325646/psychometrics-of-the-self-efficacy-consumption-of-fruit-and-vegetables-scale-in-african-american-women
#20
Lisaann S Gittner, Kevin B Gittner
PURPOSE: Assess the psychometric properties of the Self-Efficacy Consumption of Fruit and Vegetable Scale (F/V scale) in African American women. SETTING: Midwestern Health Maintenance Organization. SUBJECTS: 221 African American women age 40-65 with BMI≥30 MEASURES: F/V scale was compared to eating efficacy/availability subscale reported on the WEL and mean micronutrient intake (vitamins A, C, K, folate, potassium, and beta-carotene reported on 3-day food records...
March 8, 2017: Eating Behaviors
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