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https://www.readbyqxmd.com/read/28919902/expression-differences-of-pigment-structural-genes-and-transcription-factors-explain-flesh-coloration-in-three-contrasting-kiwifruit-cultivars
#1
Yanfei Liu, Bin Zhou, Yingwei Qi, Xin Chen, Cuihua Liu, Zhande Liu, Xiaolin Ren
Fruits of kiwifruit cultivars (Actinidia chinensis and A. deliciosa) generally have green or yellow flesh when ripe. A small number of genotypes have red flesh but this coloration is usually restricted to the inner pericarp. Three kiwifruit cultivars having red ('Hongyang'), or yellow ('Jinnong-2'), or green ('Hayward') flesh were investigated for their color characteristics and pigment contents during development and ripening. The results show the yellow of the 'Jinnong-2' fruit is due to the combined effects of chlorophyll degradation and of beta-carotene accumulation...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28888617/relationships-between-bone-mass-and-dietary-lifestyle-habits-in-japanese-women-at-3-4-months-postpartum
#2
A Hoshino, A Yamada, R Tanabe, S Noda, K Nakaoka, Y Oku, C Katayama, M Haraikawa, H Nakano, M Harada, K Uenishi, M Goseki-Sone
OBJECTIVES: The relationships between calcaneal bone mass and dietary/lifestyle habits in women at 3-4 months postpartum were examined in the context of osteoporosis prevention. STUDY DESIGN: Cross-sectional survey. METHODS: We measured bone mass using calcaneal ultrasound in mothers who brought their 3- to 4-month-old babies to healthcare centers in Japan for health examination and administered a self-report questionnaire on physical characteristics and dietary/lifestyle habits to those who agreed to participate in the survey...
September 7, 2017: Public Health
https://www.readbyqxmd.com/read/28878287/metabolomic-profiling-of-serum-retinol-in-the-alpha-tocopherol-beta-carotene-cancer-prevention-atbc-study
#3
Jiaqi Huang, Orestis A Panagiotou, Gabriella M Anic, Alison M Mondul, Linda M Liao, Andriy Derkach, Rachael Stolzenberg-Solomon, Stephanie J Weinstein, Demetrius Albanes
The role of retinol in the prevention of multifactorial chronic diseases remains uncertain, and there is sparse evidence regarding biological actions and pathways implicated in its effects on various outcomes. The aim is to investigate whether serum retinol in an un-supplemented state is associated with low molecular weight circulating metabolites. We performed a metabolomic analysis of 1,282 male smoker participants based on pre-supplementation fasting serum in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28869773/antioxidant-consumption-is-associated-with-decreased-odds-of-congenital-limb-deficiencies
#4
Nelson D Pace, Tania A Desrosiers, Suzan L Carmichael, Gary M Shaw, Andrew F Olshan, Anna Maria Siega-Riz
BACKGROUND: Approximately 1 in 2000 infants is born with a limb deficiency in the US. Research has shown that women's periconceptional diet and use of vitamin supplements can affect risk of birth defects. We investigated whether maternal consumption of nutritional antioxidants was associated with occurrence of transverse limb deficiency (TLD) and longitudinal limb deficiencies (LLD). METHODS: We analysed case-control data from mothers and their singleton infants with TLD (n = 566), LLD (n = 339), or no malformation (controls; n = 9384) in the National Birth Defects Prevention Study (1997-2009)...
September 4, 2017: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/28867793/diet-gut-microbiome-and-epigenetics-emerging-links-with-inflammatory-bowel-diseases-and-prospects-for-management-and-prevention
#5
REVIEW
Krasimira Aleksandrova, Beatriz Romero-Mosquera, Vicent Hernandez
Inflammatory bowel diseases (IBD) represent a growing public health concern due to increasing incidence worldwide. The current notion on the pathogenesis of IBD is that genetically susceptible individuals develop intolerance to dysregulated gut microflora (dysbiosis) and chronic inflammation develops as a result of environmental triggers. Among the environmental factors associated with IBD, diet plays an important role in modulating the gut microbiome, influencing epigenetic changes, and, therefore, could be applied as a therapeutic tool to improve the disease course...
August 30, 2017: Nutrients
https://www.readbyqxmd.com/read/28821981/modifiable-factors-and-esophageal-cancer-a-systematic-review-of-published-meta-analyses
#6
REVIEW
Clara Castro, Bárbara Peleteiro, Nuno Lunet
There are marked differences in the etiology of the major histological types of esophageal cancer (EC)-squamous cell carcinomas (ESCC) and adenocarcinomas (EAC). This study aimed to summarize the current scientific knowledge on modifiable risk factors for EC, by histological type, through a systematic review of meta-analyses referenced in PubMed and ISI Web of Knowledge. We identified 100 meta-analyses on risk factors for ESCC (n = 54), EAC (n = 43), or EC (n = 51). ESCC risk significantly increased with alcohol and maté drinking, smoking, red and processed meat consumption and human papillomavirus infection, while it was negatively associated with body mass index and consumption of fruit, vegetables, white meat, folate, and some carotenoids...
August 18, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28814486/serum-ghrelin-is-associated-with-risk-of-colorectal-adenocarcinomas-in-the-atbc-study
#7
Gwen Murphy, Amanda J Cross, Sanford M Dawsey, Frank Z Stanczyk, Farin Kamangar, Stephanie J Weinstein, Philip R Taylor, Satu Männistö, Demetrius Albanes, Christian C Abnet, Neal D Freedman
BACKGROUND: Colorectal cancers are the third most common cancers in women and men in the USA. While dietary and lifestyle factors such as Western diet, physical inactivity and obesity have been linked to an increased risk of this malignancy, the mechanisms for these associations are unclear. GI hormones, including ghrelin, are involved in energy balance by mediating appetite and metabolism; however, the association between ghrelin and colorectal cancer has not been studied. METHODS: We conducted a case-control study nested within the all-male Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study of Finnish smokers (aged 50-69 years) to examine serum ghrelin concentration and colorectal cancer risk...
August 16, 2017: Gut
https://www.readbyqxmd.com/read/28781774/level-of-dietary-energy-and-2-4-thiazolidinedione-alter-molecular-and-systemic-biomarkers-of-inflammation-and-liver-function-in-holstein-cows
#8
Afshin Hosseini, Mustafa Salman, Zheng Zhou, James K Drackley, Erminio Trevisi, Juan J Loor
BACKGROUND: The objective of the study was to evaluate the effect of overfeeding a moderate energy diet and a 2,4-thiazolidinedione (TZD) injection on blood and hepatic tissue biomarkers of lipid metabolism, oxidative stress, and inflammation as it relates to insulin sensitivity. RESULTS: Fourteen dry non-pregnant cows were fed a control (CON) diet to meet 100% of NRC requirements for 3 wk, after which half of the cows were assigned to a moderate-energy diet (OVE) and half of the cows continued on CON for 6 wk...
2017: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/28756617/antioxidant-vitamin-and-mineral-supplements-for-preventing-age-related-macular-degeneration
#9
REVIEW
Jennifer R Evans, John G Lawrenson
BACKGROUND: There is inconclusive evidence from observational studies to suggest that people who eat a diet rich in antioxidant vitamins (carotenoids, vitamins C, and E) or minerals (selenium and zinc) may be less likely to develop age-related macular degeneration (AMD). OBJECTIVES: To determine whether or not taking antioxidant vitamin or mineral supplements, or both, prevent the development of AMD. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (which contains the Cochrane Eyes and Vision Trials Register) (2017, Issue 2), MEDLINE Ovid (1946 to 29 March 2017), Embase Ovid (1947 to 29 March 2017), AMED (Allied and Complementary Medicine Database) (1985 to 29 March 2017), OpenGrey (System for Information on Grey Literature in Europe) (www...
July 30, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28703643/methotrexate-and-beta-carotene-loaded-lipid-polymer-hybrid-nanoparticles-a-preclinical-study-for-breast-cancer
#10
Ashay Jain, Gajanand Sharma, Varun Kushwah, Neeraj K Garg, Prashant Kesharwani, Gargi Ghoshal, Bhupinder Singh, Uma Shankar Shivhare, Sanyog Jain, Om Prakash Katare
AIM: This work was intended to investigate the targeting potential of fructose-tethered lipid-polymeric hybrid nanoparticles (F-BC-MTX-LPHNPs) co-loaded with beta carotene (BC) and methotrexate (MTX) in breast cancer therapeutics and find out the possible protective role of BC on MTX-induced toxicity. MATERIALS & METHODS: F-BC-MTX-LPHNPs were fabricated using self-assembled nano-precipitation technique. Fructose was conjugated on the surface of the particles. The in vitro cytotoxicity, sub-cellular localization and apoptotic activity of F-BC-MTX-LPHNPs were evaluated against MCF-7 breast cancer cells...
July 13, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28698186/serum-insulin-glucose-indices-of-insulin-resistance-and-risk-of-lung-cancer
#11
Ilona Argirion, Stephanie J Weinstein, Satu Männistö, Demetrius Albanes, Alison M Mondul
BACKGROUND: Although insulin may increase risk of some cancers, few studies have examined fasting serum insulin and lung cancer risk. METHODS: We examined serum insulin, glucose, and indices of insulin resistance (insulin:glucose molar ratio and homeostasis model assessment of insulin resistance [HOMA-IR]) and lung cancer risk using a case-cohort study within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Studyof Finnish men. 196 cases and 395 subcohort members were included...
July 11, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28696684/development-of-%C3%AE-carotene-loaded-organogel-based-nanoemulsion-with-improved-in-vitro-and-in-vivo-bioaccessibility
#12
Yuting Fan, Luyu Gao, Jiang Yi, Yuzhu Zhang, Wallace Yokoyama
β-Carotene (BC), a naturally occurring lipophilic carotenoid, is beneficial for human health. However, its water solubility and bioavailability are low. In this study, organogel-based nanoemulsion was successfully prepared to improve the loading amount, solubility, and bioavailability of BC. Corn oil was selected as the oil phase for the organogel as a result of the greatest release amount of BC. Tween 20 was optimized as the emulsifier based on the highest extent of lipolysis and BC bioaccessibility. The nanoemulsion was a better alternative than the organogel according to both the extent of lipolysis and BC bioaccessibility...
August 2, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28663343/fine-mapping-transcriptome-analysis-and-marker-development-for-y2-the-gene-that-conditions-%C3%AE-carotene-accumulation-in-carrot-daucus-carota-l
#13
Shelby Ellison, Douglas Senalik, Hamed Bostan, Massimo Iorizzo, Philipp Simon
Domesticated carrots, Daucus carota subsp. sativus, are the richest source of β-carotene in the US diet, which, when consumed, is converted into vitamin A, an essential component of eye health and immunity. The Y2 locus plays a significant role in beta-carotene accumulation in carrot roots, but a candidate gene has not been identified. To advance our understanding of this locus, the genetic basis of β-carotene accumulation was explored by utilizing an advanced mapping population, transcriptome analysis, and nucleotide diversity in diverse carrot accessions with varying levels of β-carotene...
August 7, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28653475/amylosucrase-mediated-%C3%AE-carotene-encapsulation-in-amylose-microparticles
#14
Carlos Andres Morales Letona, Cheon-Seok Park, Young-Rok Kim
The beta-carotene embedded amylose microparticles (BC-AmMPs) were prepared in one-step by utilizing the unique catalytic activity of amylosucrase from Deinococcus geothermalis (DgAS), which synthesizes linear amylose chains using sucrose as the sole substrate. Synthesized amylose chains self-assembled with beta carotene to form well-defined spherical microparticles with an encapsulation yield of 65%. The BC-AmMPs produced (average diameter ∼8 µm) were bright orange due to the embedded beta-carotene, and this was confirmed by Raman analysis...
June 27, 2017: Biotechnology Progress
https://www.readbyqxmd.com/read/28625776/beta-carotene-preferentially-regulates-chicken-myoblast-proliferation-withdrawal-and-differentiation-commitment-via-bco1-activity-and-retinoic-acid-production
#15
C Praud, S Al Ahmadieh, E Voldoire, Y Le Vern, E Godet, N Couroussé, B Graulet, E Le Bihan Duval, C Berri, M J Duclos
The enzyme β-carotene oxygenase 1 (BCO1) catalyzes the breakdown of provitamin A, including beta-carotene (BC), into retinal, prior to its oxidation into retinoic acid (RA). Allelic variation at the BCO1 locus results in differential expression of its mRNA and affects carotenoid metabolism specifically in chicken Pectoralis major muscle. In this context, the aim of this study was to evaluate the potential myogenic effect of BC and the underlying mechanisms in chicken myoblasts. BCO1 mRNA was detected in myoblasts derived from chicken satellite cells...
June 15, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28568053/low-vitamin-b12-increases-risk-of-gastric-cancer-a-prospective-study-of-one-carbon-metabolism-nutrients-and-risk-of-upper-gastrointestinal-tract-cancer
#16
Eugenia H Miranti, Rachael Stolzenberg-Solomon, Stephanie J Weinstein, Jacob Selhub, Satu Männistö, Philip R Taylor, Neal D Freedman, Demetrius Albanes, Christian C Abnet, Gwen Murphy
Previous studies have found associations between one-carbon metabolism nutrients and risk of several cancers, but little is known regarding upper gastrointestinal tract (UGI) cancer. We analyzed prediagnostic serum concentrations of several one-carbon metabolism nutrients (vitamin B12, folate, vitamin B6, riboflavin and homocysteine) in a nested case-control study within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study of male smokers, which was undertaken in Finland between 1985 and 1988...
September 15, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28554634/valorization-of-dacryodes-rostrata-fruit-through-the-characterization-of-its-oil
#17
Lee Hong Tee, Bao Yang, Beng Ti Tey, Eng-Seng Chan, Azrina Azlan, Amin Ismail, Jian Sun, Cheng Yuon Lau, Uma D Palanisamy, Ramakrishnan Nagasundara Ramanan, Krishnamurthy Nagendra Prasad
Dacryodes rostrata (kembayau) is an important food and oil resource for local communities in Borneo, but it is not commonly known to wider community. The objective of this work is to valorize kembayau fruit by evaluating the characteristics of the oil from the fruit. In this study, the physicochemical characteristics and the lipophilic essential nutrient; the fatty acid composition, vitamin E and beta-carotene content of oils obtained from the peel, pulp and seeds of kembayau fruits were studied. The pulp of the kembayau fruit contained highest proportion of oil, followed by peel and seed...
November 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28552108/pistacia-chinensis-strong-antioxidant-and-potent-testicular-toxicity-amelioration-agent
#18
Farah Noureen, Muhammad Rashid Khan, Naseer Ali Shah, Rahmat Ali Khan, Kiran Naz, Saadia Sattar
OBJECTIVES: To evaluate in vitro and in vivo antioxidant potency of Pistacia chinensis (P. chinensis) bark and leaves extracts along with its protective role against CCl4 induced toxicity in testis of the rat. METHODS: Various in vitro models such as DPPH, ABTS, hydrogen peroxide, superoxide, hydroxyl and nitric oxide scavenging activities, anti-lipid peroxidation activity, phospho-molybdenum activity, β carotene bleaching assay was used for analysis of antioxidant potential...
April 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28542353/identification-of-cow-and-buffalo-milk-based-on-beta-carotene-and-vitamin-a-concentration-using-fluorescence-spectroscopy
#19
Rahat Ullah, Saranjam Khan, Hina Ali, Muhammad Bilal, Muhammad Saleem
The current study presents the application of fluorescence spectroscopy for the identification of cow and buffalo milk based on β-carotene and vitamin-A which is of prime importance from the nutritional point of view. All samples were collected from healthy animals of different breeds at the time of lactation in the vicinity of Islamabad, Pakistan. Cow and buffalo milk shows differences at fluorescence emission appeared at band position 382 nm, 440 nm, 505 nm and 525 nm both in classical geometry (right angle) setup as well as front face fluorescence setup...
2017: PloS One
https://www.readbyqxmd.com/read/28539965/chemicals-compositions-antioxidant-and-anti-inflammatory-activity-of-cynara-scolymus-leaves-extracts-and-analysis-of-major-bioactive-polyphenols-by-hplc
#20
Maryem Ben Salem, Hanen Affes, Khaled Athmouni, Kamilia Ksouda, Raouia Dhouibi, Zouheir Sahnoun, Serria Hammami, Khaled Mounir Zeghal
Objective. Artichoke (Cynara scolymus L.) was one of the plant remedies for primary health care. The present study was focused on the determination of chemical composition, antioxidant activities, and anti-inflammatory activity and on analyzing its major bioactive polyphenols by HPLC. Methods. Artichoke Leaves Extracts (ALE) were analyzed for proximate analysis and phytochemical and antioxidant activity by several methods such as DDPH, ABTS, FRAP, and beta-carotene bleaching test. The carrageenan (Carr) model induced paw oedema in order to investigate the anti-inflammatory activity...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
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