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https://www.readbyqxmd.com/read/29408383/evaluation-of-synergistic-antimicrobial-effect-of-vitamins-a-b1-b2-b6-b12-c-d-e-and-k-with-antibiotics-against-resistant-bacterial-strains
#1
Shakeel Shahzad, M Adnan Ashraf, M Sajid, Aqeel Shahzad, Azhar Rafique, M Shahid Mahmood
BACKGROUND & OBJECTIVES: Multiple drug resistant super bugs of Acinetobacter baumannii and methicillin-resistant Staphylococcus aureus (MRSA) are becoming challenge for healthcare professionals. In this study, vitamins were evaluated for synergistic activity with the antibiotics. METHODS: Synergistic effect between antibiotic and stock solutions of vitamins is evaluated by using Kirby-Bauer disc diffusion assay. Distilled water and propylene glycol were used as solvent for water soluble vitamins and fat-soluble vitamins respectively...
February 2, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29379943/efficacy-of-oral-mixed-tocotrienols-in-diabetic-peripheral-neuropathy-a-randomized-clinical-trial
#2
Chee Peng Hor, Wai Yee Fung, Hock Aun Ang, Sheau Chin Lim, Li Ying Kam, Su-Way Sim, Luen Hui Lim, Wai Yee Choon, Jia Woei Wong, Alan Swee Hock Ch'ng, Kelvin Khai Meng Beh, Hong Chin Wee, Loke Meng Ong, Nurzalina Abdul Karim Khan, Syed Azhar Syed Sulaiman, Ibrahim Lutfi Shuaib, Adlina Bakar, Yusnita Yusof, Yusmawati Mohd Yusof, Fatimah Abu Bakar, Wei Shuong Tang, Hoon Lang Teh, Normala Abdul Wahid, Suriani Saaidin, Najihah Idris, Chee Kin Yoon, Hoon Ngoh Ong, Jayasumithra T Ganapathy, Ching Ee Loo, Michelle M Samy, Hadzlinda Zainal, Shalini C Sree Dharan, Bee Yen Ooi, Pei Yeing Teoh, Yi Loon Tye, Chin Aun Yeoh, Dy Win Low, Irene Looi, Kah Hay Yuen
Importance: Management of painful diabetic peripheral neuropathy remains challenging. Most therapies provide symptomatic relief with varying degrees of efficacy. Tocotrienols have modulatory effects on the neuropathy pathway and may reduce neuropathic symptoms with their antioxidative and anti-inflammatory activities. Objective: To evaluate the efficacy of oral mixed tocotrienols for patients with diabetic peripheral neuropathy. Design, Setting, and Participants: The Vitamin E in Neuroprotection Study (VENUS) was a parallel, double-blind, placebo-controlled trial that recruited participants from January 30, 2011, to December 7, 2014, with 12 months of follow-up...
January 29, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29377197/visible-light-induced-radical-mediated-dna-damage
#3
Amelia C McCue, Whitney M Moreau, Thomas A Shell
Light-responsive compounds have been used to manipulate biological systems with spatial and temporal control of the event of interest. Illumination of alkylcobalamins with green light (500 - 570 nm) produces carbon-centered radicals, which have been demonstrated to effectively cause DNA damage. Molecules that cause DNA and RNA strand scission are useful for studying polynucleotide structure and the binding of small molecules and proteins to polynucleotides. Most molecules that cause DNA damage in a light-dependent manner require high energy, short wavelength ultraviolet light, which is readily absorbed by nucleotide bases causing damage to the polynucleotides...
January 27, 2018: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29361736/route-and-type-of-formulation-administered-influences-the-absorption-and-disposition-of-vitamin-b12-levels-in-serum
#4
Luis Vitetta, Joyce Zhou, Rachel Manuel, Serena Dal Forno, Sean Hall, David Rutolo
The administration of biological compounds that optimize health benefits is an ever-evolving therapeutic goal. Pharmaceutical and other adjunctive biological compounds have been administered via many different routes in order to produce a systemic pharmacological effect. The article summarizes the findings from an Australian comparative study in adults administered vitamin B12 through different oral delivery platforms. A total of 16 subjects (9 males, 7 females) voluntarily partook in a comparative clinical study of five different vitamin B12 formulations across a six-month period, completing 474 person-hours of cumulative contribution, that was equivalent to an n = 60 participation...
January 21, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29118764/folic-acid-and-homocysteine-in-chronic-kidney-disease-and-cardiovascular-disease-progression-which-comes-first
#5
REVIEW
Giuseppe Cianciolo, Antonio De Pascalis, Luca Di Lullo, Claudio Ronco, Chiara Zannini, Gaetano La Manna
Background: Hyperhomocysteinemia (Hhcy) occurs in about 85% of chronic kidney disease (CKD) patients because of impaired renal metabolism and reduced renal excretion. Folic acid (FA), the synthetic form of vitamin B9, is critical in the conversion of homocysteine (Hcy) to methionine. If there is not enough intake of FA, there is not enough conversion, and Hcy levels are raised. Summary: Hhcy is regarded as an independent predictor of cardiovascular morbidity and mortality in end-stage renal disease...
October 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29101774/dextrose-prolotherapy-for-chronic-shoulder-pain-a-case-report
#6
Casey Seenauth, Vance Inouye, Jeffrey O Langland
Context • Shoulder pain is one of the most common pain complaints reported by patients. Consensus is lacking on its ideal treatment, and many different treatments are available and used. Prolotherapy is an injection-based therapy that has shown significant results in treating many common musculoskeletal pain conditions, including osteoarthritis, lateral epicondylosis, and low-back pain. Objective • The study intended to evaluate the use of dextrose prolotherapy in the treatment of shoulder pain. Design • The research team performed a case study...
January 2018: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/29032242/combination-of-vitamin-b12-active-forms-improved-fetal-growth-in-wistar-rats-through-up-regulation-of-placental-mir-16-and-mir-21-levels
#7
Tejas Shah, Sanjay Mishra, Amol More, Suhas Otiv, Kishori Apte, Kalpana Joshi
AIM: Epidemiological studies have indicated importance of folate and vitamin (B12) during pregnancy. Also available evidence on efficacy of B12 forms viz. Cyanocobalamin (Cbl), Methylcobalamin (MeCbl), Adenosylcobalamin (AdCbl) and Hydroxycobalamin (HCbl) in preventing or treating cobalamin deficiency is limited. The present study examines the effect of various forms of B12 in combination with folate during pregnancy and their effect on gestational outcomes. MAIN METHOD: In the present study, we examined the effect of various vitamin B12 forms in presence of recommended folate (RFol: 400μg/day) and high folate (HFol: 5mg/day) on gestational outcomes in female Wistar rats...
December 15, 2017: Life Sciences
https://www.readbyqxmd.com/read/28816120/b-vitamins-in-stroke-prevention-time-to-reconsider
#8
REVIEW
J David Spence, Qilong Yi, Graeme J Hankey
B vitamin therapy lowers plasma total homocysteine concentrations, and might be a beneficial intervention for stroke prevention; however, cyanocobalamin (a form of vitamin B12) can accelerate decline in renal function and increase the risk of cardiovascular events in patients with impaired renal function. Although early trials did not show benefit in reduction of stroke, these results might have been due to harm in participants with impaired renal function. In patients with diabetic nephropathy, cyanocobalamin is harmful, whereas B vitamins appear to reduce cardiovascular events in study participants with normal renal function...
September 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28747433/efficient-methylation-of-c2-in-l-tryptophan-by-the-cobalamin-dependent-radical-s-adenosylmethionine-methylase-tsrm-requires-an-unmodified-n1-amine
#9
Anthony J Blaszczyk, Bo Wang, Alexey Silakov, Jackson V Ho, Squire J Booker
TsrM catalyzes the methylation of C2 in l-tryptophan (Trp). This reaction is the first step in the biosynthesis of the quinaldic acid moiety of the thiopeptide antibiotic thiostrepton, which exhibits potent activity against Gram-positive pathogens. TsrM is a member of the radical S-adenosylmethionine (SAM) superfamily of enzymes, but it does not catalyze the formation of 5'-deoxyadenosin-5'-yl or any other SAM-derived radical. In addition to a [4Fe-4S] cluster, TsrM contains a cobalamin cofactor that serves as an intermediate methyl carrier in its reaction...
September 15, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28678474/methylcobalamin-dependent-radical-sam-c-methyltransferase-fom3-recognizes-cytidylyl-2-hydroxyethylphosphonate-and-catalyzes-the-nonstereoselective-c-methylation-in-fosfomycin-biosynthesis
#10
Shusuke Sato, Fumitaka Kudo, Seung-Young Kim, Tomohisa Kuzuyama, Tadashi Eguchi
A methylcobalamin (MeCbl)-dependent radical S-adenosyl-l-methionine (SAM) methyltransferase Fom3 was found to catalyze the C-methylation of cytidylyl-2-hydroxyethylphosphonate (HEP-CMP) to give cytidylyl-2-hydroxypropylphosphonate (HPP-CMP), although it was originally proposed to catalyze the C-methylation of 2-hydroxyethylphosphonate to give 2-hydroxypropylphosphonate in the biosynthesis of a unique C-P bond containing antibiotic fosfomycin in Streptomyces. Unexpectedly, the Fom3 reaction product from HEP-CMP was almost a 1:1 diastereomeric mixture of HPP-CMP, indicating that the C-methylation is not stereoselective...
July 18, 2017: Biochemistry
https://www.readbyqxmd.com/read/28676841/an-in-vitro-model-of-gastric-inflammation-and-treatment-with-cobalamin
#11
T R Elliott, A L Guildford
Pernicious anaemia (PA) is an autoimmune condition where antibodies target intrinsic factor and parietal cells, reducing the patient's ability to absorb cobalamin promoting atrophic gastritis. Treatment guidelines are based on excretion data of hydroxocobalamin from healthy individuals obtained 50 years ago. This manuscript describes the use of phorbol 12-myristate 13-acetate (PMA) to stimulate low grade inflammation in an epithelial colorectal cell line to assess the efficacy of methylcobalamin and hydroxocobalamin...
2017: International Journal of Inflammation
https://www.readbyqxmd.com/read/28667789/efficacy-of-oral-methylcobalamin-in-treatment-of-vitamin-b12-deficiency-anemia-in-children
#12
Deepti Verma, Jagdish Chandra, Praveen Kumar, Shailaja Shukla, Shantanu Sengupta
To demonstrate the efficacy of oral methylcobalamin in treating vitamin B12 (vitB12) deficiency anemia, our prospective observational study enrolled 28 children with both macrocytic anemia and low holotranscobalamin (HoloTC) levels. Their hematological and biochemical parameters pre- and posttreatment at 1 month were compared. Hemoglobin showed mean increase of 2.89 g/dl (P < 0.001), rising above 10 g/dl in 24 patients (85.7%). Reticulocytes peaked at 1 week. Mean fall in mean corpuscular volume of 24...
December 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28551266/characterization-of-extracellular-vitamin-b12-producing-lactobacillus-plantarum-strains-and-assessment-of-the-probiotic-potentials
#13
Ping Li, Qing Gu, Lanlan Yang, Yue Yu, Yuejiao Wang
We investigated extracellular vitamin B12-producing Lactobacillus strains and their characteristics in tolerance to environmental stresses, gastric acid and bile salts. Two isolates, Lactobacillus plantarum LZ95 and CY2, showed high extracellular B12 production, 98±15μg/L and 60±9μg/L respectively. Extracellular B12 from LZ95 were identified as adenosylcobalamin and methylcobalamin using a combination of solid phase extraction and reverse-phase HPLC, while that from CY2 was adenosylcobalamin. Both strains grew under environmental stresses, and LZ95 exhibited better tolerance to low temperature and high ethanol concentration...
November 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28538514/long-term-outcome-of-4-patients-with-transcobalamin-deficiency-caused-by-2-novel-tcn2-mutations
#14
Marwan Nashabat, Gustavo Maegawa, Peter H Nissen, Ebba Nexo, Hussain Al-Shamrani, Mohammed Al-Owain, Majid Alfadhel
Cobalamin (vitamin B12 [Cbl]) is an essential cofactor for many biochemical pathways. Transcobalamin (TC) is required to internalize Cbl into the cells through membrane receptor-mediated endocytosis. Cbl is then processed in the cytoplasm and mitochondria by complementation factors leading to its active metabolites; methylcobalamin and 5-deoxyadenosyl-cobalamin. Deficiency of TC results in an elevation in methylmalonic acid and homocysteine. Patients usually present with macrocytic anemia, pancytopenia, failure to thrive, gastrointestinal symptoms, and neurological dysfunction...
November 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28483920/cobalamin-riboswitches-exhibit-a-broad-range-of-ability-to-discriminate-between-methylcobalamin-and-adenosylcobalamin
#15
COMPARATIVE STUDY
Jacob T Polaski, Samantha M Webster, James E Johnson, Robert T Batey
Riboswitches are a widely distributed class of regulatory RNAs in bacteria that modulate gene expression via small-molecule-induced conformational changes. Generally, these RNA elements are grouped into classes based upon conserved primary and secondary structure and their cognate effector molecule. Although this approach has been very successful in identifying new riboswitch families and defining their distributions, small sequence differences between structurally related RNAs can alter their ligand selectivity and regulatory behavior...
July 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28405134/methylcobalamin-in-vitamin-b12-deficiency-to-give-or-not-to-give
#16
Ashwin Kamath, Sudhakar Pemminati
No abstract text is available yet for this article.
January 2017: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/28223907/comparative-bioavailability-and-utilization-of-particular-forms-of-b12-supplements-with-potential-to-mitigate-b12-related-genetic-polymorphisms
#17
REVIEW
Cristiana Paul, David M Brady
CONTEXT: Three natural forms of vitamin B12 are commercially available: methylcobalamin (MeCbl), adenosylcobalamin (AdCbl), and hydroxycobalamin (OHCbl), all of which have been shown in clinical studies to improve vitamin B12 status. They are bioidentical to the B12 forms occurring in human physiology and animal foods. In contrast, cyanocobalamin (CNCbl), a synthetic B12 compound used for food fortification and in some supplements, occurs only in trace amounts in human tissues as a result of cyanide intake from smoking or other sources...
February 2017: Integrative Medicine
https://www.readbyqxmd.com/read/28179161/electrospun-nanofiber-sheets-incorporating-methylcobalamin-promote-nerve-regeneration-and-functional-recovery-in-a-rat-sciatic-nerve-crush-injury-model
#18
Koji Suzuki, Hiroyuki Tanaka, Mitsuhiro Ebara, Koichiro Uto, Hozo Matsuoka, Shunsuke Nishimoto, Kiyoshi Okada, Tsuyoshi Murase, Hideki Yoshikawa
Peripheral nerve injury is one of common traumas. Although injured peripheral nerves have the capacity to regenerate, axon regeneration proceeds slowly and functional outcomes are often poor. Pharmacological enhancement of regeneration can play an important role in increasing functional recovery. In this study, we developed a novel electrospun nanofiber sheet incorporating methylcobalamin (MeCbl), one of the active forms of vitamin B12 homologues, to deliver it enough locally to the peripheral nerve injury site...
February 5, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28167430/vitamin-b12-in-the-spotlight-again
#19
REVIEW
Jennifer Bridwell-Rabb, Catherine L Drennan
The ability of cobalamin to coordinate different upper axial ligands gives rise to a diversity of reactivity. Traditionally, adenosylcobalamin is associated with radical-based rearrangements, and methylcobalamin with methyl cation transfers. Recently, however, a new role for adenosylcobalamin has been discovered as a light sensor, and a methylcobalamin-dependent enzyme has been identified that is suggested to transfer a methyl anion. Additionally, recent studies have provided a wealth of new information about a third class of cobalamin-dependent enzymes that do not appear to use an upper ligand...
April 2017: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/28096758/effects-of-acute-ingestion-of-a-pre-workout-dietary-supplement-with-and-without-p-synephrine-on-resting-energy-expenditure-cognitive-function-and-exercise-performance
#20
Y Peter Jung, Conrad P Earnest, Majid Koozehchian, Elfego Galvan, Ryan Dalton, Dillon Walker, Christopher Rasmussen, Peter S Murano, Mike Greenwood, Richard B Kreider
BACKGROUND: The purpose of this study was to examine the effects of acute ingestion of a pre-workout dietary supplement (PWS) with and without p-synephrine (S) on perceptions of readiness to perform, cognitive function, exercise performance, and markers of safety. METHODS: In a randomized, double-blind, and counterbalanced manner; 25 healthy and recreationally active male and female participants ingested a flavored maltodextrin placebo (PLA), a PWS containing beta-alanine (3 g), creatine nitrate as a salt (2 g), arginine alpha-ketoglutarate (2 g), N-Acetyl-L-Tyrosine (300 mg), caffeine (284 mg), Mucuna pruiriens extract standardized for 15% L-Dopa (15 mg), Vitamin C as Ascorbic Acid (500 mg), niacin (60 mg), folate as folic acid (50 mg), and Vitamin B12 as Methylcobalamin (70 mg) with 2 g of maltodextrin and flavoring; or, the PWS with Citrus aurantium (PWS + S) extract standardized for 30% p-synephrine (20 mg)...
2017: Journal of the International Society of Sports Nutrition
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