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https://www.readbyqxmd.com/read/28716427/influence-of-l-dopa-on-subtle-motor-signs-in-heterozygous-parkin-and-pink1-mutation-carriers
#1
Anne Weissbach, Inke R König, Katja Hückelheim, Peter P Pramstaller, Elisa Werner, Norbert Brüggemann, Vera Tadic, Katja Lohmann, Tobias Bäumer, Alexander Münchau, Meike Kasten, Christine Klein
INTRODUCTION: A latent nigrostriatal deficit and its possible clinical consequences in asymptomatic heterozygous Parkin and PINK1 mutation carriers (AMC) have been a matter of investigation in recent years. Notably, mild Parkinsonian signs in heterozygous mutation carriers can be so subtle that they may be missed if not specifically investigated. METHODS: We studied 15 heterozygous Parkin and PINK1 AMC and 18 age- and sex-matched mutation-negative controls using a standardized video, instructing the probands to perform relevant parts of the UPDRS III to investigate fine motor movements at baseline and after first-time L-Dopa administration...
July 8, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28715455/synthetic-melanin-bound-to-subunit-vaccine-antigens-significantly-enhances-cd8-t-cell-responses
#2
Antoine F Carpentier, Frédéric Geinguenaud, Thi Tran, Floraly Sejalon, Antoine Martin, Laurence Motte, Eric Tartour, Claire Banissi
Cytotoxic T-lymphocytes (CTLs) play a key role in immunity against cancer; however, the induction of CTL responses with currently available vaccines remains difficult. Because several reports have suggested that pigmentation and immunity might be functionally linked, we investigated whether melanin can act as an adjuvant in vaccines. Short synthetic peptides (8-35 amino acids long) containing T-cell epitopes were mixed with a solution of L-Dopa, a precursor of melanin. The mixture was then oxidized to generate nanoparticles of melanin-bound peptides...
2017: PloS One
https://www.readbyqxmd.com/read/28710399/downregulation-of-blood-serum-microrna-29-family-in-patients-with-parkinson-s-disease
#3
Xiaochen Bai, Yilin Tang, Mei Yu, Lei Wu, Fengtao Liu, Jianliang Ni, Zishan Wang, Jinghui Wang, Jian Fei, Wei Wang, Fang Huang, Jian Wang
There is currently no reliable and easily applicable diagnostic marker for Parkinson's disease (PD). The aims of the present study were to compare the expression profiles of the microRNA29 family (miR-29s) in blood serum from patients with PD with healthy controls and to clarify whether the expression of miR-29s is correlated with disease severity, duration or L-dopa therapy and whether expression depends on the gender and age of patients. The levels of blood serum miR-29s in 80 patients with PD and 80 unaffected controls were assessed by reverse transcription-quantitative real-time PCR...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28704778/eradication-of-helicobacter-pylori-infection-might-improve-clinical-status-of-patients-with-parkinson-s-disease-especially-on-bradykinesia
#4
Huijing Liu, Wen Su, Shuhua Li, Wei Du, Xinxin Ma, Ying Jin, Kai Li, Haibo Chen
OBJECTIVES: Previous studies have shown that Helicobacter pylori infection might make clinical status worse in patients with Parkinson's disease and Helicobacter pylori eradication might improve clinical status by modifying the pharmacokinetics of L-dopa. Here, we investigate whether Helicobacter pylori eradication could benefit idiopathic parkinsonism and Helicobacter pylori infection will effect which aspect of motor symptom significantly. PATIENTS AND METHODS: A cohort study involving idiopathic Parkinson's disease patients, screened for Helicobacter status by (13)C urea breath test...
July 5, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28703120/effects-of-body-habitus-on-internal-radiation-dose-calculations-using-the-5-year-old-anthropomorphic-male-models
#5
Tianwu Xie, Niels Kuster, Habib Zaidi
Computational phantoms are commonly used in internal radiation dosimetry to assess the amount and distribution pattern of energy deposited in various parts of the human body from different internal radiation sources. Radiation dose assessments are commonly performed on predetermined reference computational phantoms while the argument for individualized patient-specific radiation dosimetry exists. This study aims to evaluate the influence of body habitus on internal dosimetry and to quantify the uncertainties in dose estimation correlated with the use of fixed reference models...
July 13, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28700507/pramipexole-induced-limb-dystonia-and-its-associated-complex-regional-pain-syndrome-in-idiopathic-parkinson-s-disease-a-case-report
#6
Donghwi Park
RATIONALE: This case may be due to basal ganglia dysfunction, which was probably caused by abnormal activation of dopamine 1-like receptor (D1R) boosted by pramipexole binding on dopamine 3-like receptor (D3R) in a situation where D3R was overexpressed by the chronic treatment of L-dopa. PATIENT CONCERNS: Striatal hand and foot deformities. DIAGNOSES: Striatal hand and foot deformities with CRPS. INTERVENTIONS: Steroid treatemnt and withdrawal of the pramipexole...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28699287/an-alternative-method-for-the-analysis-of-melanin-production-in-cryptococcus-neoformans-sensu-lato-and-cryptococcus-gattii-sensu-lato
#7
Raimunda S N Brilhante, Jaime D A España, Lucas P de Alencar, Vandbergue S Pereira, Débora de S C M Castelo-Branco, Waldemiro de A Pereira-Neto, Rossana de A Cordeiro, José J C Sidrim, Marcos F G Rocha
Melanin is an important virulence factor for several microorganisms, including Cryptococcus neoformans sensu lato and Cryptococcus gattii sensu lato, thus, the assessment of melanin production and its quantification may contribute to the understanding of microbial pathogenesis. The objective of this study was to standardise an alternative method for the production and indirect quantification of melanin in C. neoformans sensu lato and C. gattii sensu lato. Eight C. neoformans sensu lato and three C. gattii sensu lato, identified through URA5 methodology, Candida parapsilosis ATCC 22019 (negative control) and one Hortaea werneckii (positive control) were inoculated on minimal medium agar with or without L-DOPA, in duplicate, and incubated at 35°C, for 7 days...
July 12, 2017: Mycoses
https://www.readbyqxmd.com/read/28698499/molecular-mechanisms-behind-free-radical-scavengers-function-against-oxidative-stress
#8
REVIEW
Fereshteh Ahmadinejad, Simon Geir Møller, Morteza Hashemzadeh-Chaleshtori, Gholamreza Bidkhori, Mohammad-Saeid Jami
Accumulating evidence shows that oxidative stress is involved in a wide variety of human diseases: rheumatoid arthritis, Alzheimer's disease, Parkinson's disease, cancers, etc. Here, we discuss the significance of oxidative conditions in different disease, with the focus on neurodegenerative disease including Parkinson's disease, which is mainly caused by oxidative stress. Reactive oxygen and nitrogen species (ROS and RNS, respectively), collectively known as RONS, are produced by cellular enzymes such as myeloperoxidase, NADPH-oxidase (nicotinamide adenine dinucleotide phosphate-oxidase) and nitric oxide synthase (NOS)...
July 10, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28694016/-18-f-fdopa-positron-emission-tomography-in-manganese-exposed-workers
#9
Susan R Criswell, Susan Searles Nielsen, Mark Warden, Joel S Perlmutter, Stephen M Moerlein, Hubert P Flores, John Huang, Lianne Sheppard, Noah Seixas, Harvey Checkoway, Brad A Racette
Occupational manganese (Mn) exposure is associated with the development of parkinsonism; however, the mechanism of neurotoxicity is unknown. Brain positron emission tomography (PET) imaging provides a non-invasive method of assessing dopamineric neuronal function. 6-[(18)F]fluoro-L-DOPA (FDOPA) PET reflects in-vivo nigrostriatal function, but results in Mn exposure are conflicting. The objective of this study was to investigate the association between Mn exposure secondary to occupational welding, FDOPA striatal uptake, and clinical parkinsonism as measured by Unified Parkinson Disease Rating Scale motor subscore 3 (UPDRS3) scores...
July 7, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28690095/evolution-of-polyketide-synthesis-in-a-dothideomycete-forest-pathogen
#10
I Kutay Ozturk, Pranav Chettri, Pierre-Yves Dupont, Irene Barnes, Rebecca L McDougal, Geromy G Moore, Andre Sim, Rosie E Bradshaw
Fungal secondary metabolites have many important biological roles and some, like the toxic polyketide aflatoxin, have been intensively studied at the genetic level. Complete sets of polyketide synthase (PKS) genes can now be identified in fungal pathogens by whole genome sequencing and studied in order to predict the biosynthetic potential of those fungi. The pine needle pathogen Dothistroma septosporum is predicted to have only three functional PKS genes, a small number for a hemibiotrophic fungus. One of these genes is required for production of dothistromin, a polyketide virulence factor related to aflatoxin, whose biosynthetic genes are dispersed across one chromosome rather than being clustered...
July 6, 2017: Fungal Genetics and Biology: FG & B
https://www.readbyqxmd.com/read/28687316/levodopa-l-dopa-attenuates-endoplasmic-reticulum-stress-response-and-cell-death-signaling-through-drd2-in-sh-sy5y-neuronal-cells-under-%C3%AE-synuclein-induced-toxicity
#11
Juhyun Song, Byeong C Kim, Dai-Trang T Nguyen, Manikandan Samidurai, Seong-Min Choi
Parkinson's disease (PD) is characterized by the formation of Lewy bodies (LBs) in dopaminergic neurons. α-Synuclein (α-syn), a major protein component of LBs, is known to regulate synaptic plasticity, with a crucial role in memory and motor function in the central nervous system. Levodopa (L-3,4-dihydroxyphenylalanine; also known as L-DOPA) is considered the most effective medication for controlling the symptoms of PD. However, it is unclear whether L-DOPA improves the neuropathology of PD. In the present study, we investigated the effect of L-DOPA on SH-SY5Y neuronal cells under α-syn-induced toxicity...
July 4, 2017: Neuroscience
https://www.readbyqxmd.com/read/28673613/parkinsonism-and-other-movement-disorders-in-23-cases-of-neurocysticercosis
#12
Fernando Alarcón, Yuri Cedeño, Justo García de Yébenes
INTRODUCTION: Parkinsonism and other movement disorders have been occasionally described in neurocysticercosis (NCC) but their clinical features and pathogenesis are not well understood. METHODS: This is a descriptive study conducted over 20 years. We studied 590 consecutive patients from the NCC Registry at Eugenio Espejo Hospital, Quito, Ecuador, and found 23 subjects who developed movement disorders. We investigated the clinical features, localization of brain lesions, severity of infection and neurological deficit as well as the outcome of the patients...
June 20, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28669542/opposite-effects-of-l-dopa-and-dbs-stn-on-saccadic-eye-movements-in-advanced-parkinson-s-disease
#13
Małgorzata Dec-Ćwiek, Marcin Tutaj, Jean-Michel Gracies, Jens Volkmann, Monika Rudzińska, Agnieszka Słowik, Andrzej Szczudlik
OBJECTIVE: To assess the effects of l-dopa and deep brain stimulation of the subthalamic nucleus (DBS-STN) on saccadic eye movements in patients with Parkinson's disease (PD). METHODS: Visually and internally guided horizontal saccades were evaluated using a saccadometer in 64 patients with advanced PD and 48 healthy controls. Forty-four pharmacologically treated patients were assessed in their "med-off" (OFF) and "med-on" (ON) status, whereas 20 DBS-STN treated patients were assessed in their "med-off, stim-off" (OFF) and "med-off, stim-on" (ON) status...
June 24, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/28666710/homozygous-alpha-synuclein-p-a53v-in-familial-parkinson-s-disease
#14
Hiroyo Yoshino, Makito Hirano, A Jon Stoessl, Yoko Imamichi, Aya Ikeda, Yuanzhe Li, Manabu Funayama, Ikuko Yamada, Yusaku Nakamura, Vesna Sossi, Matthew J Farrer, Kenya Nishioka, Nobutaka Hattori
We have assessed the frequency of alpha-synuclein (SNCA) mutations in Japanese patients with familial or sporadic Parkinson's disease (PD) and surveyed their associated clinical manifestations. We screened SNCA exon 3 in 988 patients without SNCA multiplications (430 with autosomal dominant PD and 558 with sporadic PD). We detected 1 patient harboring a homozygous SNCA p.A53V substitution albeit with an autosomal dominant pattern of disease inheritance (frequency 2/860 = 0.2%). The proband manifested slow and progressive parkinsonism at 55 years...
June 27, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28662719/erratum-to-functional-implications-of-microbial-and-viral-gut-metagenome-changes-in-early-stage-l-dopa-na%C3%A3-ve-parkinson-s-disease-patients
#15
J R Bedarf, F Hildebrand, L P Coelho, S Sunagawa, M Bahram, F Goeser, P Bork, U Wüllner
No abstract text is available yet for this article.
June 29, 2017: Genome Medicine
https://www.readbyqxmd.com/read/28660940/the-effect-of-l-dopa-hydroxyl-groups-on-the-formation-of-supramolecular-hydrogels
#16
Nicola Zanna, Debora Iaculli, Claudia Tomasini
Fmoc-l-DOPA-d-Oxd-OH was prepared starting from commercially available l-DOPA. Its gelation ability was tested by comparison with Fmoc-l-Tyr-d-Oxd-OH and Fmoc-l-Phe-d-Oxd-OH using ten different triggers. Among them, only GdL, CaCl2 and ZnCl2 form strong hydrogels with the three gelators. The analysis of the aerogels obtained by freeze drying the hydrogels show that the three gelators always induce the formation of dense networks, which strongly depend on the nature of the gelator. Rheological analysis of these samples demonstrates that stronger gels were obtained using the l-Tyr containing gelator, while the l-DOPA containing hydrogels were characterized by a storage modulus approximately one order of magnitude lower...
June 29, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28655632/normative-data-of-dopaminergic-neurotransmission-functions-in-substantia-nigra-measured-with-mri-and-pet-neuromelanin-dopamine-synthesis-dopamine-transporters-and-dopamine-d2-receptors
#17
Hiroshi Ito, Hiroshi Kawaguchi, Fumitoshi Kodaka, Hiroyuki Takuwa, Yoko Ikoma, Hitoshi Shimada, Yasuyuki Kimura, Chie Seki, Hitoshi Kubo, Shiro Ishii, Harumasa Takano, Tetsuya Suhara
The central dopaminergic system is of major importance in the pathophysiology of Parkinson's disease, schizophrenia, and other neuropsychiatric disorders. In the present study, the normative data of dopaminergic neurotransmission functions in the midbrain, consisting of neuromelanin, dopamine synthesis, dopamine transporters and dopamine D2 receptors, were constructed using magnetic resonance (MR) imaging and positron emission tomography (PET). PET studies with L-[β-(11)C]DOPA, [(18)F]FE-PE2I and [(11)C]FLB457 and MRI studies were performed on healthy young men...
June 26, 2017: NeuroImage
https://www.readbyqxmd.com/read/28642128/immunomodulation-of-parkinson-s-disease-using-mucuna-pruriens-mp
#18
REVIEW
Sachchida Nand Rai, Hareram Birla, Walia Zahra, Saumitra Sen Singh, Surya Pratap Singh
Immune control is associated with nigrostriatal neuroprotection for Parkinson's disease (PD); though its direct cause and effect relationships have not yet been realized and modulating the immune system for therapeutic gain has been openly discussed. While the pathobiology of PD remains in study, neuroinflammation is thought to speed nigrostriatal degeneration. The neuroinflammatory cascade associated with PD begins with aggregation of misfolded or post-translationally modified α-synuclein (α-syn). Such aggregation results in neuronal cell death and the presence of chronically activated glia (microglia and astroglia), leading to the production of proinflammatory cytokines like tumor necrosis factor alpha (TNF-α), interleukin-1 beta (IL-1β), IL-6, and enzymes such as nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and cyclooxygenase-2 (COX-2)...
June 19, 2017: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/28640753/mechanism-of-antihypertensive-effect-of-mucuna-pruriens-l-seed-extract-and-its-isolated-compounds
#19
Mohammad Yaseen Khan, Vimal Kumar
Background In the search of safe and effective lead molecules from natural sources, Mucuna pruriens (MP) L. (Fabaceae) seeds were utilized for exploring the antihypertensive potential. Traditionally, it is used as diuretic and hypotensive. Methods Bioassay-guided fractions were utilized for the isolation of active compounds by column chromatography. IC50 value, enzyme kinetics and inhibition mechanism were determined. In vivo time and dose-dependent hypotensive study followed by changes in mean arterial pressure (MAP) induced by angiotensin I (3 nmol/kg), angiotensin II (3 nmol/kg), and bradykinin (10 nmol/kg) in anesthetized rats was done...
June 21, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/28637871/phosphorylation-at-serine-31-targets-tyrosine-hydroxylase-to-vesicles-for-transport-along-microtubules
#20
Ana Jorge-Finnigan, Rune Kleppe, Kunwar Jung-Kc, Ming Ying, Michael Marie, Ivan Rios-Mondragon, Michael F Salvatore, Jaakko Saraste, Aurora Martinez
Tyrosine hydroxylase (TH) catalyzes the conversion of L-tyrosine into L-Dopa, which is the rate-limiting step in the synthesis of catecholamines, particularly dopamine in dopaminergergic neurons. Low dopamine levels and death of the dopaminergic neurons are hallmarks of Parkinson's disease (PD), where α-synuclein is also a key player. TH is highly regulated, notably by phosphorylation of several Ser/Thr residues in the N-terminal tail. However, the functional role of TH phosphorylation at the Ser31 site (THpSer31) remains unclear...
June 21, 2017: Journal of Biological Chemistry
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