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https://www.readbyqxmd.com/read/28074522/protective-effects-of-tacalcitol-against-oxidative-damage-in-human-epidermal-melanocytes
#1
Qi-Lin Li, Yan-Hua Wu, Mu Niu, Xiao-Juan Lu, Yong-Hua Huang, Dan-Hua He
BACKGROUND: Oxidative damage may lead to the dysfunction of melanocytes (MCs) and is one of the causative mechanisms involved in the pathogenesis of vitiligo. OBJECTIVES: This study was designed to investigate the protective effects of the vitamin D3 analog tacalcitol on oxidative damage induced by hydrogen peroxide (H2 O2 ) in human epidermal MCs. METHODS: Human epidermal MCs were cultured and identified by l-DOPA staining and HMB-45 immunohistochemical staining...
February 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28073433/misperceptions-and-parkinson-s-disease
#2
REVIEW
Joseph H Friedman
Most of the neurobehavioral aspects of Parkinson's disease have been well established and studied, but many are not well known, and hardly studied. This article focuses on several behavioral abnormalities that are common, and frequently cause difficulty for the patient and family due to lack of recognition as part of the disease. While it is well known that L-Dopa dyskinesias are frequently not recognized or under appreciated by patients, a similar lack of recognition may affect the patient's own speech volume, where their center of gravity is located, whether they are tilted to one side, and their under-recognition of others' emotional displays...
January 4, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28063406/contemporary-imaging-of-incidentally-discovered-adrenal-masses
#3
REVIEW
Daniel J Wale, Ka Kit Wong, Benjamin L Viglianti, Domenico Rubello, Milton D Gross
Adrenal lesions are routinely encountered incidentally in clinical practice. Although most of these lesions are benign, malignancy needs to be excluded. Therefore, the initial clinical workup is to exclude aggressive characteristics suggesting malignancy and to identify characteristics predictive of the most common benign lesion, an adrenal adenoma. Predicting a benign adenoma using a variety of imaging modalities has been widely studied using unenhanced computed tomography (CT), contrast enhanced CT, and magnetic resonance (MR) imaging...
January 4, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28059502/chiral-nh-controlled-supramolecular-metallacycles
#4
Jinqiao Dong, Chunxia Tan, Kang Zhang, Yan Liu, Paul J Low, Jianwen Jiang, Yong Cui
Chiral NH functionalities-based discrimination is a key feature of Nature's chemical armory, yet selective binding of biologically active molecules in synthetic systems with high enantioselectivity poses significant challenges. Here we report the assembly of three chiral fluorescent Zn6L6 metallacycles from pyridyl-functionalized Zn(salalen) and/or Zn(salen) complexes. Each of these metallacycles has a nanoscale hydrophobic cavity decorated with six, three or zero chiral NH functionalities and packs into a three-dimensional supramolecular porous framework...
January 6, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28041966/different-roles-of-retinal-dopamine-in-albino-guinea-pig-myopia
#5
Junfeng Mao, Shuangzhen Liu
PURPOSE: To investigate whether the different role of ocular dopamine was involved in the myopic development between spontaneous myopia (SM) and form deprivation myopia (FDM) in albino guinea pigs. METHODS: 55 myopic animals were randomly divided into SM, Levodapa (L-DOPA), L-DOPA+carbidopa and vehicle. 70 non-myopic animals were randomly divided into normal control, FDM, L-DOPA+FDM, L-DOPA+carbidopa+FDM and vehicle. Once per day, for 14days, L-DOPA (10mg/kg) was injected intraperitoneally, and carbidopa (1μg) was injected at the same time into the peribulbar space of the right eye...
December 29, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/28034624/determinants-of-denervation-independent-depletion-of-putamen-dopamine-in-parkinson-s-disease-and-multiple-system-atrophy
#6
David S Goldstein, Patti Sullivan, Courtney Holmes, Deborah C Mash, Irwin J Kopin, Yehonatan Sharabi
BACKGROUND: Severe putamen dopamine depletion characterizes Parkinson's disease (PD) and multiple system atrophy (MSA). The extent of the depletion is greater than can be accounted for by loss of nigrostriatal dopaminergic terminals alone. We used putamen tissue levels and ratios of cysteinyl and parent catechols to explore possible denervation-independent abnormalities of dopamine synthesis and fate in PD and MSA. 5-S-Cysteinyldopa (Cys-DOPA) is produced from spontaneous oxidation of DOPA and 5-S-cysteinyldopamine (Cys-DA) from spontaneous oxidation of DA...
December 15, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28028844/improved-tlc-bioautographic-assay-for-qualitative-and-quantitative-estimation-of-tyrosinase-inhibitors-in-natural-products
#7
Jinge Zhou, Qingjiu Tang, Tao Wu, Zhihong Cheng
INTRODUCTION: TLC bioautography for tyrosinase inhibitors has made recent progress; however, an assay with a relative low consumption of enzyme and quantitative capability would greatly advance the efficacy of related TLC bioautographic assays. OBJECTIVE: An improved TLC bioautographic assay for detecting tyrosinase inhibitors was developed and validated in this study. METHODS: L-DOPA (better water-solubility than L-tyrosine) was used as the substrate instead of reported L-tyrosine...
December 28, 2016: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28024573/l-dopa-co-drugs-in-nanostructured-lipid-carriers-a-comparative-study
#8
Rita Cortesi, Elisabetta Esposito, Markus Drechsler, Gabriella Pavoni, Ivana Cacciatore, Maddalena Sguizzato, Antonio Di Stefano
This paper describes the production and characterization of nanostructured lipid carriers (NLC) containing four different levodopa (LD) co-drugs (PD), named PDA (3,4-diacetyloxy-LD-caffeic acid co-drug), PDB (lipoic acid-dopamine co-drug), PDC (lipoic acid-3,4-diacetoxy-dopamine co-drug), and PDD (dimeric LD co-drug containing an alkyl linker), with therapeutic potential in Parkinson's disease. These co-drugs were produced with the aim of prolonging the pharmacological activity of LD, enhancing its absorption and protecting it from metabolism...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28018865/catecholamine-stimulated-growth-of-aeromonas-hydrophila-requires-the-tonb2-energy-transduction-system-but-is-independent-of-the-amonabactin-siderophore
#9
Yuhao Dong, Jin Liu, Maoda Pang, Hechao Du, Nannan Wang, Furqan Awan, Chengping Lu, Yongjie Liu
The growth-stimulating effects of catecholamine stress hormones have been demonstrated in many pathogens. However, catecholamine-induced growth and its underlying mechanisms remain poorly understood in Aeromonas hydrophila. The present study sought to demonstrate that norepinephrine (NE), epinephrine (Epi), dopamine (Dopa), and L-dopa stimulate the growth of A. hydrophila in iron-restricted media containing serum. NE exhibited the strongest growth stimulation, which could be blocked by adrenergic antagonists...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28017864/modifying-effects-of-carboxyl-group-on-the-interaction-of-recombinant-s100a8-a9-complex-with-tyrosinase
#10
Fatemeh NematiNiko, Koorosh Goodarzvand Chegini, Hamideh Asghari, Abbas Amini, Nematollah Gheibi
Tyrosinase is a determinant enzyme for modulating melanin production as its abnormal activity can result in an increased amount of melanin. Reduction of tyrosinase activity has been targeted for preventing and healing hyperpigmentation of skin, such as melanoma and age related spots. The aim of this systematic study is to investigate whether recombinant S100A8/A9 and its modified form reduce the activity of mushroom tyrosinase (MT) through changing its structure. Recombinant His-Tagged S100A8 and S100A9 are expressed in Escherichia coli BL21 (DE3) and modified using Woodward's reagent K which is a carboxyl group modifier...
December 22, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28005447/gynostemma-pentaphyllum-ethanolic-extract-protects-against-memory-deficits-in-an-mptp-lesioned-mouse-model-of-parkinson-s-disease-treated-with-l-dopa
#11
Kyung Sook Kim, Ting Ting Zhao, Keon Sung Shin, Hyun Jin Park, Yoon Jeong Cho, Kyung Eun Lee, Seung Hwan Kim, Myung Koo Lee
This study investigated the effects of ethanol extract from Gynostemma pentaphyllum (GP-EX) on memory deficits in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned mouse model of Parkinson's disease (PD) (MPTP-lesioned mice). MPTP (30 mg/kg/day, 5 days)-lesioned mice showed deficits of habit learning memory and spatial memory, which were further aggravated by treatment with L-3,4-dihydroxyphenylalanine (L-DOPA) (25 mg/kg, 21 days). However, treatment with GP-EX (50 mg/kg, 21 days) ameliorated memory deficits in MPTP-lesioned mice treated with L-DOPA (25 mg/kg): GP-EX prevented the decreases in retention latency time in the passive avoidance test and tyrosine hydroxylase-immunopositive cells and dopamine levels in the nigrostriatum...
December 22, 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28003105/motor-cortex-plasticity-can-indicate-vulnerability-to-motor-fluctuation-and-high-l-dopa-need-in-drug-na%C3%A3-ve-parkinson-s-disease
#12
Asha Kishore, Praveen James, Syam Krishnan, Lydia Yahia-Cherif, Sabine Meunier, Traian Popa
INTRODUCTION: Motor cortex plasticity is reported to be decreased in Parkinson's disease in studies which pooled patients in various stages of the disease. Whether the early decrease in plasticity is related to the motor signs or is linked to the future development of motor complications of treatment is unclear. The aim of the study was to test if motor cortex plasticity and its cerebellar modulation are impaired in treatment-naïve Parkinson's disease, are related to the motor signs of the disease and predict occurrence of motor complications of treatment...
December 13, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27990314/deep-brain-stimulation-for-parkinson-s-disease-prior-to-l-dopa-treatment-a-case-report
#13
Domenico Servello, Christian Saleh, Alberto R Bona, Edvin Zekaj, Carlotta Zanaboni, Mauro Porta
BACKGROUND: Leva-dopa (L-dopa) is the gold-standard treatment for Parkinson's disease (PD). Deep brain stimulation is generally reserved for patients who become refractory to l-dopa treatment. CASE DESCRIPTION: We present a male patient with a 9-year course of PD who at 53 years of age preferred deep brain stimulation (DBS) of the subthalamic nucleus over initial l-dopa treatment. The patient argued that he wanted to avoid the serious adverse effects of l-dopa, which would have presented within his time of full professional activity...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27981510/aberrant-cpg-methylation-mediates-abnormal-transcription-of-mao-a-induced-by-acute-and-chronic-l-3-4-dihydroxyphenylalanine-administration-in-sh-sy5y-neuronal-cells
#14
Zhaofei Yang, Xuan Wang, Jian Yang, Min Sun, Yong Wang, Xiaomin Wang
L-3,4-dihydroxyphenylalanine (L-dopa) remains the most effective drug for therapy of Parkinson's disease (PD); however, long-term use of it causes serious side effects. L-dopa-induced dyskinesia (LID) has consistently been related to L-dopa-derived excessive dopamine release, but the mechanisms have not been addressed very clear. Monoamine oxidase A (MAO-A) is one of the key enzymes in dopamine metabolism and therefore may be involved in L-dopa-induced side effects. And, epigenetic modification controls MAO-A gene transcription...
December 15, 2016: Neurotoxicity Research
https://www.readbyqxmd.com/read/27977906/new-insights-into-the-effects-of-biomaterial-chemistry-and-topography-on-the-morphology-of-kidney-epithelial-cells
#15
Frits Hulshof, Carolien Schophuizen, Milos Mihajlovic, Clemens van Blitterswijk, Rosalinde Masereeuw, Jan de Boer, Dimitrios Stamatialis
Increasing incidence of renal pathology in the western world calls for innovative research for the development of cell-based therapies such as a Bio-artificial kidney (BAK) device. To fulfill the multitude of kidney functions, the core component of the BAK is a "living membrane" consisting of a tight kidney cell monolayer with preserved functional organic ion transporters cultured on a polymeric membrane surface. This membrane, on one side, is in contact with blood and therefore there should have excellent blood compatibility whereas on the other side should facilitate functional monolayer formation...
December 15, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27960413/poly-ester-urea-based-adhesives-improved-deployment-and-adhesion-by-incorporation-of-poly-propylene-glycol-segments
#16
Jinjun Zhou, Vrushali Bhagat, Matthew L Becker
The adhesive nature of mussels arises from the catechol moiety in the 3,4-dihydroxyphenylalanine (DOPA) amino acid, one of the many proteins that contribute to the unique adhesion properties of mussels. Inspired by these properties, many biomimetic adhesives have been developed over the past few years in an attempt to replace adhesives such as fibrin, cyanoacrylate, and epoxy glues. In the present work, we synthesized ethanol soluble but water insoluble catechol functionalized poly(ester urea) random copolymers that help facilitate delivery and adhesion in wet environments...
December 14, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27956461/annals-express-l-dopa-therapy-interferes-with-urine-catecholamine-analysis-in-children-with-suspected-neuroblastoma-a-case-series
#17
Alison Kelly, Rajeev Srivastava, Ellie Dow, D Fraser Davidson
Neuroblastoma is the most common extracranial malignancy diagnosed in childhood. Clinical presentation is variable, and metastatic disease is common at diagnosis. Analyses of urinary catecholamines and their metabolites are commonly requested as a first-line investigation when clinical suspicion exists. Levodopa (L-Dopa) therapy is utilised as a treatment for a number of disorders in childhood, including Dopa-responsive dystonia. Neuroblastoma may mimic some of the clinical features of this disorder. L-Dopa can interfere with analysis of urinary catecholamines and their metabolites, and complicate interpretation of results...
December 12, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27941527/striatal-dopamine-transporter-modulation-after-rotigotine-results-from-a-pilot-single-photon-emission-computed-tomography-study-in-a-group-of-early-stage-parkinson-disease-patients
#18
Carlo Rossi, Dario Genovesi, Paolo Marzullo, Assuero Giorgetti, Elena Filidei, Giovanni Umberto Corsini, Ubaldo Bonuccelli, Roberto Ceravolo
INTRODUCTION: Several in vitro data have reported negative interference by dopamine-agonists on the expression of dopamine transporter (DAT), whereas the majority of imaging studies have shown that neither L-dopa nor dopamine-agonists interfere with DAT availability. As yet, there are no in vivo studies on DAT expression after treatment with rotigotine. METHODS: We evaluated presynaptic nigrostriatal function in 8 patients with de novo Parkinson disease (age, 59 ± 6...
January 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/27941374/delayed-gastric-emptying-in-advanced-parkinson-disease-correlation-with-therapeutic-doses
#19
Alberto Bestetti, Antonella Capozza, Marco Lacerenza, Luigi Manfredi, Francesca Mancini
INTRODUCTION: Gastrointestinal dysfunction is often described in patients with Parkinson disease (PD), and gastrointestinal symptoms are usually attributed to gastroparesis. The consequent delayed gastric emptying (GE) may be an important pharmacokinetic mechanism underlying some of the response fluctuations that develop after long-term levodopa (L-dopa) therapy.The aim of this prospective study was to assess GE time by a liquid meal scintigraphy, in PD patients, and to correlate them with demographic, clinical, and therapeutic data...
December 9, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27940340/inhibition-of-tyrosinase-by-fumaric-acid-integration-of-inhibition-kinetics-with-computational-docking-simulations
#20
Lin Gou, Jinhyuk Lee, Jun-Mo Yang, Yong-Doo Park, Hai-Meng Zhou, Yi Zhan, Zhi-Rong Lü
Fumaric acid (FA), which is naturally found in organisms, is a well known intermediate of the citric acid cycle. We evaluated the effects of FA on tyrosinase activity and structure via enzyme kinetics and computational simulations. FA was found to be a reversible inhibitor of tyrosinase and its induced mechanism was the parabolic non-competitive inhibition type with IC50=13.7±0.25mM and Kislope=12.64±0.75mM. We newly established the equation for the dissociation constant (Kislope) for the parabolic inhibition type in this study...
December 7, 2016: International Journal of Biological Macromolecules
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