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hymenoptera venom allergy

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https://www.readbyqxmd.com/read/28507496/safety-and-efficacy-of-venom-immunotherapy-a-real-life-study
#1
Agnieszka Kołaczek, Dawid Skorupa, Monika Antczak-Marczak, Piotr Kuna, Maciej Kupczyk
INTRODUCTION: Venom immunotherapy (VIT) is recommended as the first-line treatment for patients allergic to Hymenoptera venom. AIM: To analyze the safety and efficacy of VIT in a real life setting. MATERIAL AND METHODS: One hundred and eighty patients undergoing VIT were studied to evaluate the safety, efficacy, incidence and nature of symptoms after field stings and adverse reactions to VIT. RESULTS: Significantly more patients were allergic to wasp than bee venom (146 vs...
April 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28503403/diagnostics-in-hymenoptera-venom-allergy-current-concepts-and-developments-with-special-focus-on-molecular-allergy-diagnostics
#2
Thilo Jakob, David Rafei-Shamsabadi, Edzard Spillner, Sabine Müller
BACKGROUND: The high rate of asymptomatic sensitization to Hymenoptera venom, difficulty in correctly identifying Hymenoptera and loss of sensitization over time make an accurate diagnosis of Hymenoptera venom allergy challenging. Although routine diagnostic tests encompassing skin tests and the detection of venom-specific IgE antibodies with whole venom preparations are reliable, they offer insufficient precision in the case of double sensitized patients or in those with a history of sting anaphylaxis, in whom sensitization cannot be proven or only to the presumably wrong venom...
2017: Allergo Journal International
https://www.readbyqxmd.com/read/28501976/component-resolved-diagnosis-in-hymenoptera-anaphylaxis
#3
REVIEW
D Tomsitz, K Brockow
PURPOSE OF REVIEW: Hymenoptera anaphylaxis is one of the leading causes of severe allergic reactions and can be fatal. Venom-specific immunotherapy (VIT) can prevent a life-threatening reaction; however, confirmation of an allergy to a Hymenoptera venom is a prerequisite before starting such a treatment. Component resolved diagnostics (CRD) have helped to better identify the responsible allergen. RECENT FINDINGS: Many new insect venom allergens have been identified within the last few years...
June 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28497674/the-vespid-allergy-quality-of-life-questionnaire-cultural-adaptation-and-translation-to-portuguese
#4
D Silva, A M Pereira, N Santos, L Amaral, L Delgado, J N Oude Elberink, A Coimbra
A cross-cultural translation of the Vespid Allergy Quality of Life Questionnaire (VQLQ) to the Portuguese population (VQLQ-P) was performed, assessing its applicability in wasp and in non-beekeeper bee venom allergic patients. Additionally, we evaluated a Visual Analogue Scale (VAS) to estimate hymenoptera allergy interference with daily life. Methods. Cross-cultural translation was performed according to recommendations. The final VQLQ-P version, the Expectation of Outcome questionnaire (EoQ), EQ-5D and VAS were applied to wasp (n = 19) and non-beekeeper bee venom allergic patients (n = 30)...
May 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28485877/diagnostic-precision-of-component-resolved-vs-extract-based-in-vitro-diagnosis-of-hymenoptera-venom-allergy-effects-on-clinical-management
#5
Florian Seyfarth, Diana Miguel, Sibylle Schliemann, Uta-Christina Hipler
BACKGROUND: The measurement of specific IgE (sIgE) antibodies plays a key role in the diagnosis of honeybee and wasp venom allergy. In recent years, component-resolved diagnosis (CRD) has been introduced, which allows for the measurement of sIgE antibodies against Api m 1, Ves v 1, Ves v 5, and Pol d 5, as well as cross-reactive carbohydrate determinants (CCDs). These tests are intended to help determine the clinical relevance of any given sensitization, especially in patients with dual sensitization...
May 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28435107/wasp-venomic-unravelling-the-toxins-arsenal-of-polybia-paulista-venom-and-its-potential-pharmaceutical-applications
#6
REVIEW
Amilcar Perez-Riverol, José Roberto Aparecido Dos Santos-Pinto, Alexis Musacchio Lasa, Mario Sergio Palma, Márcia Regina Brochetto-Braga
Polybia paulista (Hymenoptera: Vespidae) is a neotropical social wasp from southeast Brazil. As most social Hymenoptera, venom from P. paulista comprises a complex mixture of bioactive toxins ranging from low molecular weight compounds to peptides and proteins. Several efforts have been made to elucidate the molecular composition of the P. paulista venom. Data derived from proteomic, peptidomic and allergomic analyses has enhanced our understanding of the whole envenoming process caused by the insect sting...
April 19, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28380475/long-term-follow-up-of-children-after-venom-immunotherapy-low-adherence-to-anaphylaxis-guidelines
#7
Claudia Fiedler, Ulrich Miehe, Regina Treudler, Wieland Kiess, Freerk Prenzel
BACKGROUND: Data on the long-term outcome of children after specific venom immunotherapy (VIT) are limited. Therefore, we assessed sting recurrence and anaphylaxis relapse rates as well as adherence to anaphylaxis guidelines with regard to the availability of emergency equipment and education status. METHODS: For this long-term survey, data of 311 children with a history of anaphylactic reactions to hymenoptera stings were collected by chart review. We included patients who were treated with a 3-year VIT between 1993 and 2009 and had completed a questionnaire...
2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28370618/mass-spectrometry-to-complement-standardization-of-house-dust-mite-and-other-complex-allergenic-extracts
#8
REVIEW
J Spiric, A Reuter, R L Rabin
In the United States, the Center for Biologics Evaluation and Research of the US Food and Drug Administration regulates biologics used for diagnosis and treatment of allergic diseases. The Code of Federal Regulations 21CFR680.3(e) states that when measured, the potency of an allergenic extract is assessed according to its allergenic activity. As of 2016, 19 allergenic extracts are standardized for potency in the United States. While these standardized extracts constitute a minority of those available, they treat the most prevalent allergies (e...
May 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28257631/clinical-practice-recommendations-for-allergen-specific-immunotherapy-in-children-the-italian-consensus-report
#9
REVIEW
Giovanni Battista Pajno, Roberto Bernardini, Diego Peroni, Stefania Arasi, Alberto Martelli, Massimo Landi, Giovanni Passalacqua, Antonella Muraro, Stefania La Grutta, Alessandro Fiocchi, Luciana Indinnimeo, Carlo Caffarelli, Elisabetta Calamelli, Pasquale Comberiati, Marzia Duse
Allergen-specific immunotherapy (AIT) is currently recognized as a clinically effective treatment for allergic diseases, with a unique disease-modifying effect. AIT was introduced in clinical practice one century ago, and performed in the early years with allergenic extracts of poor quality and definition. After the mechanism of allergic reaction were recognized, the practice of AIT was refined, leading to remarkable improvement in the efficacy and safety profile of the treatment. Currently AIT is accepted and routinely prescribed worldwide for respiratory allergies and hymenoptera venom allergy...
January 23, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28211342/key-issues-in-hymenoptera-venom-allergy-an-update
#10
REVIEW
T Alfaya Arias, V Soriano Gómis, T Soto Mera, A Vega Castro, J M Vega Gutiérrez, A Alonso Llamazares, D Antolín Amérigo, F J Carballada Gonzalez, C Dominguez Noche, D Gutierrez Fernandez, L Marques Amat, A Martinez Arcediano, M Martinez San Ireneo, A Moreno Ancillo, Y Puente Crespo, B Ruiz Leon, L Sánchez Morillas
In this review, the Hymenoptera Allergy Committee of the SEAIC analyzes the most recent scientific literature addressing problems related to the diagnosis of hymenoptera allergy and to management of venom immunotherapy. Molecular diagnosis and molecular risk profiles are the key areas addressed. The appearance of new species of hymenoptera that are potentially allergenic in Spain and the associated diagnostic and therapeutic problems are also described. Finally, we analyze the issue of mast cell activation syndrome closely related to hymenoptera allergy, which has become a new diagnostic challenge for allergists given its high prevalence in patients with venom anaphylaxis...
2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28120601/hymenoptera-venom-allergy-a-closer-collaboration-is-needed-between-allergists-and-emergency-physicians
#11
A Ciccarelli, C Calabrò, C Imperatore, G Scala
Background. Hymenoptera stings are sometimes fatal in venom-allergic patients. Fatalities mostly occur in previously stung subjects, especially those with a history of systemic reactions, and could be avoided if patients were properly informed of the existence of a prevention strategy for insect stings, referred to an allergy follow-up and prescribed auto-injectable epinephrine and/or venom-specific immunotherapy (VIT). We sought to assess knowledge and awareness of Hymenoptera Venom Allergy (HVA) in a small sample of Emergency Physicians in our geographic area...
January 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28105558/immunology-of-bee-venom
#12
REVIEW
Daniel Elieh Ali Komi, Farzaneh Shafaghat, Ricardo D Zwiener
Bee venom is a blend of biochemicals ranging from small peptides and enzymes to biogenic amines. It is capable of triggering severe immunologic reactions owing to its allergenic fraction. Venom components are presented to the T cells by antigen-presenting cells within the skin. These Th2 type T cells then release IL-4 and IL-13 which subsequently direct B cells to class switch to production of IgE. Generating venom-specific IgE and crosslinking FcεR1(s) on the surface of mast cells complete the sensitizing stage in allergic individuals who are most likely to experience severe and even fatal allergic reactions after being stung...
January 20, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28073614/underuse-of-allergy-services-for-patients-having-systemic-reactions-to-hymenoptera-venom-stings
#13
Anil M Patel, Vivian Wang, Ami Philipp, Joseph S Yusin
No abstract text is available yet for this article.
March 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28007089/epidemiology-of-anaphylaxis-at-a-tertiary-care-center-a-report-of-730-cases
#14
Alexei Gonzalez-Estrada, Stacy K Silvers, Asaf Klein, Katrina Zell, Xiao-Feng Wang, David M Lang
BACKGROUND: Recent data reveal that the rate of anaphylaxis is increasing and suggest that idiopathic anaphylaxis may account for most of these cases. OBJECTIVE: To determine the pattern of anaphylaxis at a tertiary care referral center. METHODS: A retrospective electronic medical record review spanning 12 years (2002-2013) identified patients with anaphylaxis. RESULTS: Of the 4,777 records reviewed, 730 patients met our anaphylaxis definition...
January 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27996943/insect-venom-immunotherapy-analysis-of-the-safety-and-tolerance-of-3-buildup-protocols-frequently-used-in-spain
#15
D Gutiérrez Fernández, A Moreno-Ancillo, S Fernández Meléndez, C Domínguez-Noche, P Gálvez Ruiz, T Alfaya Arias
INTRODUCTION: Hymenoptera venom immunotherapy (VIT) is an effective treatment but not one devoid of risk, as both local and systemic adverse reactions may occur, especially in the initial phases. We compared the tolerance to 3 VIT buildup protocols and analyzed risk factors associated with adverse reactions during this phase. MATERIALS AND METHODS: We enrolled 165 patients divided into 3 groups based on the buildup protocol used (3, 4, and 9 weeks). The severity of systemic reactions was evaluated according to the World Allergy Organization model...
2016: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/27986410/simplification-of-intradermal-skin-testing-in-hymenoptera-venom-allergic-children
#16
Ewa Cichocka-Jarosz, Marcin Stobiecki, Piotr Brzyski, Iwona Rogatko, Marita Nittner-Marszalska, Krystyna Sztefko, Ewa Czarnobilska, Grzegorz Lis, Anna Nowak-Węgrzyn
BACKGROUND: The direct comparison between children and adults with Hymenoptera venom anaphylaxis (HVA) has never been extensively reported. Severe HVA with IgE-documented mechanism is the recommendation for venom immunotherapy, regardless of age. OBJECTIVE: To determine the differences in the basic diagnostic profile between children and adults with severe HVA and its practical implications. METHODS: We reviewed the medical records of 91 children and 121 adults...
March 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27924689/hymenoptera-venom-allergy-in-outdoor-workers-occupational-exposure-clinical-features-and-effects-of-allergen-immunotherapy
#17
Alessandra Toletone, Susanna Voltolini, Giovanni Passalacqua, Guglielmo Dini, Donatella Bignardi, Paola Minale, Emanuela Massa, Alessio Signori, Costantino Troise, Paolo Durando
OBJECTIVES: To describe (i) the clinical characteristics of workers, exposed to hymenoptera stings, with an ascertained diagnosis of Hymenoptera Venom Allergy (HVA), (ii) the specific role of occupational exposure, (iii) the effect of Venom Immunotherapy (VIT) in reducing the severity of allergic episodes in workers exposed to repeated stings of hymenoptera, and (iv) the management of the occupational consequences caused by allergic reactions due to hymenoptera stings. METHODS: Between 2000 and 2013 an observational study, including patients referred to the regional reference hospital of Liguria, Italy, with an ascertained diagnosis of HVA and treated with VIT, was performed...
February 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27914814/rush-venom-immunotherapy-in-children
#18
Ronit Confino-Cohen, Yossi Rosman, Arnon Goldberg
BACKGROUND: Rush venom immunotherapy (VIT) is highly effective in Hymenoptera venom allergy. Still, specific data regarding its safety and efficiency in children are rather sparse. OBJECTIVES: The objective of this study was to better evaluate the safety and efficiency of rush VIT in this specific age group. METHODS: Children younger than 16 years with systemic reaction to insect sting involving, at least, one body system other than skin and children aged 16-18 years with any kind of systemic reaction were offered conventional or rush VIT with a build-up phase that lasted 3 days...
May 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/27907922/distinct-contributory-factors-determine-basophil-allergen-sensitivity-in-grass-pollen-rhinitis-and-in-anaphylactic-wasp-venom-allergy
#19
Peter Korošec, Mira Šilar, Peter Kopač, Renato Eržen, Mihaela Zidarn, Mitja Košnik
BACKGROUND: We sought to determine whether basophil-allergen sensitivity could be transferred to donor basophils by passive IgE sensitisation in allergic rhinitis and anaphylactic Hymenoptera venom hypersensitivity. METHODS: We studied 15 wasp venom-, 19 grass pollen- and 2 house dust mite-allergic patients, 2 healthy donors, and 8 wasp venom-allergic donors. In all subjects, we first evaluated the initial basophil response to wasp venom, grass pollen, or house dust mite allergen...
2016: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/27826019/molecular-cloning-expression-and-ige-immunoreactivity-of-phospholipase-a1-a-major-allergen-from-polybia-paulista-hymenoptera-vespidae-venom
#20
Amilcar Perez-Riverol, Franco Dani Campos Pereira, Alexis Musacchio Lasa, Luis Gustavo Romani Fernandes, José Roberto Aparecido Dos Santos-Pinto, Débora Lais Justo-Jacomini, Gabriel Oliveira de Azevedo, Murilo Luiz Bazon, Mario Sergio Palma, Ricardo de Lima Zollner, Márcia Regina Brochetto-Braga
Polybia paulista (Hymenoptera: Vespidae) is a clinically relevant social wasp that frequently causes stinging accidents in southeast Brazil. To date, diagnosis and specific immunotherapy (SIT) of allergy are based on the use of crude venom extracts. Production of recombinant forms of major allergens from P. paulista venom will improve diagnosis and SIT of allergic patients by reducing the incidence of cross-reactivity and non-specific sensitization. Here, we describe the molecular cloning, heterologous expression, purification and IgE-mediated immunodetection of phospholipase A1 (Poly p 1), a major allergen from P...
December 15, 2016: Toxicon: Official Journal of the International Society on Toxinology
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