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What"s new in dermatology

Gentiane Monsel, Eric Caumes
No abstract text is available yet for this article.
July 2015: Journal of Travel Medicine
James Q Del Rosso
Oral antibiotics have been used for the treatment of acne vulgaris for six decades. Among dermatologists, tetracyclines represent at least three-fourths of the oral antibiotics prescribed in clinical practice. Unlike other specialties, antibiotic use in dermatology is predominantly for the treatment of noninfectious disorders, such as acne vulgaris and rosacea, which usually involves prolonged therapy over several weeks to months as compared to short courses used to treat cutaneous infections. At the present time, doxycycline and minocycline are the most commonly prescribed tetracyclines in dermatology, used primarily for treatment of acne vulgaris with a long overall favorable track record of effectiveness and safety...
May 2015: Journal of Clinical and Aesthetic Dermatology
Gregory J Dehmer, Manesh R Patel
No abstract text is available yet for this article.
July 7, 2015: Circulation
Justine Czernielewski, Daniel Hohl
Progress in paediatric dermatology is achieved in both research and therapeutic fields. In infectiology, scabies and bed bugs are a scourge for dermatologists, with an important recent outbreak. This article describes the fundamental clinical signs to look for, when suspecting such diagnosis. Hair dermatoscopy seems to be also very precious as a new tool for the diagnosis of ringworm. Regarding eczemas, atopic dermatitis is supported by S. Aureus's skin colonization, the target of eradication of new products in ongoing studies...
April 1, 2015: Revue Médicale Suisse
D H Suh, H H Kwon
There are four central factors that contribute to acne physiopathology: the inflammatory response, colonization with Propionibacterium acnes, increased sebum production and hypercornification of the pilosebaceous duct. In addition, research in the areas of diet and nutrition, genetics and oxidative stress is also yielding some interesting insights into the development of acne. In this paper we review some of the most recent research and novel concepts revealed in this work, which has been published by researchers from diverse academic disciplines including dermatology, immunology, microbiology and endocrinology...
July 2015: British Journal of Dermatology
Artur Beberok, Dorota Wrześniok, Michał Otręba, Ewa Buszman
BACKGROUND: Fluoroquinolones are a group of broad spectrum bactericidal antibiotics used to treat various infections of urinary and respiratory systems, as well as in ophthalmology and dermatology. This class of antibiotics causes toxic effects directed to pigmented tissues, what introduces a serious limitation to their use. The aim of this work was to examine the impact of sparfloxacin on melanogenesis and the antioxidant defense system in normal human epidermal melanocytes, adult, lightly pigmented (HEMa-LP)...
February 2015: Pharmacological Reports: PR
Brian J Simmons, Robert D Griffith, Leyre A Falto-Aizpurua, Keyvan Nouri
Acne is a common affliction among many teens and some adults that usually resolves over time. However, the severe sequela of acne scarring can lead to long-term psychological and psychiatric problems. There exists a multitude of modalities to treat acne scars such as more invasive surgical techniques, subcision, chemical peels, ablative lasers, fractional lasers, etc. A more recent technique for the treatment of acne scars is nonablative radiofrequency (RF) that works by passing a current through the dermis at a preset depth to produce small thermal wounds in the dermis which, in turn, stimulates dermal remodeling to produce new collagen and soften scar defects...
2014: Clinical, Cosmetic and Investigational Dermatology
L Meunier
This non-exhaustive review focuses on publications that have been the subject of randomized controlled trials. It will also include results from research that may lead to new therapeutic perspectives. The selected articles were published between October 2013 and September 2014. The vast majority of them were dedicated to the treatment of psoriasis (anti-TNF, ustekinumab, antibodies against IL-17 or its receptors, anti-IL-23, anti-CD6 and ponesimod). Selected papers will also address the following diseases: atopic dermatitis, urticaria, acne, bullous diseases, alopecia areata, skin infections, acne rosacea and leg ulcers...
December 2014: Annales de Dermatologie et de Vénéréologie
P Plantin
Regular analysis of the major journals in dermatology and paediatrics has been used to select forty articles which are representative of the past year in paediatric dermatology. This selection is not exhaustive but rather reflects the interests of the author and also the dominant topics in paediatric dermatology in 2013-2014.
December 2014: Annales de Dermatologie et de Vénéréologie
J-M Amici
This "What's new in instrumental dermatology" focuses on cutaneous oncologic surgery, base on a review of the 2012-2014 literature. First, the ability of dermatologists to make a good "oncologic reading of tumors" is the key of radical surgical treatment. Advantages and disadvantages of the biopsy are discussed. Then, the second message is the management of anticoagulants, that should not be interrupted for skin surgery. Despite recommendations, this practice is not followed in 40% of cases; this point is critical because bleeding complications are minor compared to potential morbidity of thrombotic events when stopping these medications...
December 2014: Annales de Dermatologie et de Vénéréologie
A Barbaud
Dermatoses have been better characterized as hypochromic vitiligo in subjects with dark skin or the acquired racquet nails associated with hyperparathyroidism. The innate immunity has a central role in the new classification of auto inflammatory diseases, neutrophilic dermatoses, neutrophilic urticaria or pseudo-neutrophilic urticaria. Comorbidities have been studied e.g. cardiovascular co morbidities for psoriasis, IBD associated with hidradenitis suppurativa or neurological disorders associated with pemphigoid...
December 2014: Annales de Dermatologie et de Vénéréologie
Andrea T Borchers, Carl L Keen, Arthur C Huntley, M Eric Gershwin
Lyme disease was originally identified in Lyme, Connecticut, based upon an unusual cluster of what appeared to be patients with juvenile rheumatoid arthritis. It was subsequently identified as a new clinical entity originally called Lyme arthritis based on the observation that arthritis was a major clinical feature. However, Lyme arthritis is now called Lyme disease based upon the understanding that the clinical features include not only arthritis, but also potential cardiac, dermatologic and neurologic findings...
February 2015: Journal of Autoimmunity
Matthew A Lenardis, Robert S Solomon, Fok-Han E Leung
BACKGROUND: Telemedicine is increasingly being used as part of routine practice for many physicians and healthcare providers across the country. Due to its visual nature, dermatology is ideally suited to benefit from this new technology. The use of teledermatology (telemedicine in dermatology) in a primary care setting allows for an expert opinion without the need for an in-person referral. Furthermore, it can improve patient access in remote areas. Store-and-forward teledermatology is the most commonly employed method...
2014: BMC Research Notes
Steven R Feldman
Topical treatment is a pillar of dermatologic practice. The delivery of drug by a topical vehicle is dependent on complex physical chemistry and on how well patients apply the product. The potency of topical agents is not solely dependent on the concentration of active drug in the vehicle. A corticosteroid molecule may have vastly different potency depending on what vehicle is used to deliver it. Similarly, a new gel vehicle is able to deliver considerably more active antifungal than an older vehicle technology and may represent a promising vehicle for other novel formulations...
April 2014: Journal of Drugs in Dermatology: JDD
V M Leis-Dosil, C Garrido-Gutiérrez, R M Díaz-Díaz
In 1936, Covisa and Bejarano published a treatise entitled Elementos de Dermatología (The Elements of Dermatology). In this surprisingly modern book they abandoned the nosological debates characteristic of the 19th century and instead classified diseases according to their etiology and pathogenesis based on the scientific and technical advances of the time. Moreover, unlike other books available at the time, which were essentially adaptations of foreign texts, this was the first medical work to reflect the reality of Spanish medicine...
April 2014: Actas Dermo-sifiliográficas
Klaus Dornmair
Tissue-invasive T cells are observed in many inflammatory dermatological diseases, but in most cases, it is not known how they were attracted, what they might recognize, and to which extent they are activated. Answering these questions is surely essential for understanding pathogeneses of the diseases. In a recent issue of Experimental Dermatology, Smith et al. showed that early signalling events in skin-resident T cells may be investigated by multiplex immunoprecipitation flow cytometry, even if only few T cells are available from skin biopsy samples...
June 2014: Experimental Dermatology
James Q Del Rosso, Joshua Zeichner
This article is the first in a periodic series of therapeutic topics with short reviews gleaned from major dermatology meetings, especially Scientific Poster Sessions, and is designed to provide information that may assist the readers in adapting information from the literature to their clinical practice. The topics covered in this issue are discussions of the clinical relevance of newer information about acne pathophysiology, acne in adult women, and topical corticosteroid spray formulations for chronic plaque psoriasis...
January 2014: Journal of Clinical and Aesthetic Dermatology
David Spoerl, Thomas Harr, Jörg D Seebach
In 2013, new crucial data dealing with the treatment options for chronic idiopathic and physical urticaria have been published. In this article, after a short introduction where we discuss the classification and the pathogenesis of the disease, we will focus on the therapeutic approach in patients with chronic urticaria. In particular, considering the data available on the treatment with omalizumab, we will discuss the indications and treatment modalities of chronic urticaria.
January 15, 2014: Revue Médicale Suisse
Balakrishnan Nirmal, Sarvajnamurthy A Sacchidanand
No abstract text is available yet for this article.
January 2014: Indian Journal of Dermatology, Venereology and Leprology
B Guillot
Innovations in dermatological therapy remain rare. In 2013, increase in the knowledge of mechanism of action and place in the therapeutic strategies concern some recent drugs. For psoriasis treatment, efficacy and safety of anti IL-17 and anti JAK pathway has been demonstrated in randomized studies versus placebo. In other inflammatory diseases, the role of rituximab in auto immune bullous diseases and of omalizumab in chronic urticaria is better known. This year was published the first randomized trial using anti TNF in hidradenitis suppurativa with positive but limited effects...
November 2013: Annales de Dermatologie et de Vénéréologie
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