Dong Ying, Qiyu He, Weikun Tian, Yanling Chen, Xiaoping Zhang, Siling Wang, Chang Liu, Zihao Chen, Yu Liu, Lijuan Fu, Li Yan, Ling Wang, Zimin Tang, Lin Wang, Zizheng Zheng, Ningshao Xia
BACKGROUND AND AIMS: HEV ORF2 antigen (Ag) in serum has become a tool for diagnosing current HEV infection. Particularly, urinary shedding of HEV Ag has been gaining increasing interest. We aim to uncover the origin, antigenicity, diagnostic performance, and diagnostic significance of Ag in urine in HEV infection. APPROACH AND RESULTS: Clinical serum and urine samples from patients with acute and chronic HEV infection were analyzed for their Ag levels. Ag in urine was analyzed by biochemical and proteomic approaches...
September 15, 2022: Hepatology: Official Journal of the American Association for the Study of Liver Diseases