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https://www.readbyqxmd.com/read/27888753/gastrointestinal-bleeding-and-intracranial-hemorrhage-in-concomitant-users-of-warfarin-and-antihyperlipidemics
#1
Charles E Leonard, Colleen M Brensinger, Warren B Bilker, Stephen E Kimmel, Xu Han, Young Hee Nam, Joshua J Gagne, Margaret J Mangaali, Sean Hennessy
BACKGROUND: Drug interactions, particularly those involving warfarin, are a major clinical and public health problem. Minimizing serious bleeding caused by anticoagulants is a recent major focus of the United States (US) Department of Health and Human Services. This study quantified the risk of gastrointestinal bleeding (GIB) and intracranial hemorrhage (ICH) among concomitant users of warfarin and individual antihyperlipidemics. METHODS: The authors conducted a high-dimensional propensity score-adjusted cohort study of new concomitant users of warfarin and an antihyperlipidemic, among US Medicaid beneficiaries from five states during 1999-2011...
November 12, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27885885/septic-encephalopathy-and-septic-encephalitis-%C3%A2-%C3%A2-%C3%A2-%C3%A2
#2
Simone C Tauber, Helmut Eiffert, Wolfgang Brück, Roland Nau
During the last two decades, septic encephalopathy (SE) was recognized as a clinically relevant problem with a high prevalence in patients at admission and during their hospital stay. SE is a condition associated with increased mortality and morbidity such as long-term cognitive impairment. Areas covered: This review illustrates the pathophysiology of sepsis-associated encephalopathy and encephalitis involving blood-brain-barrier dysfunction and neuroinflammation caused by endothelial and microglial activation by endogenous or pathogen-derived compounds, hypoxia by impaired microvascular regulation and septic shock as well as imbalance of neurotransmitters...
November 25, 2016: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/27876411/disruption-of-mitochondrial-quality-control-in-peripheral-artery-disease-new-therapeutic-opportunities
#3
REVIEW
Cintia B Ueta, Katia S Gomes, Márcio A Ribeiro, Daria Mochly-Rosen, Julio C B Ferreira
Peripheral artery disease (PAD) is a multifactorial disease initially triggered by reduced blood supply to the lower extremities due to atherosclerotic obstructions. It is considered a major public health problem worldwide, affecting over 200 million people. Management of PAD includes smoking cessation, exercise, statin therapy, antiplatelet therapy, antihypertensive therapy and surgical intervention. Although these pharmacological and non-pharmacological interventions usually increases blood flow to the ischemic limb, morbidity and mortality associated with PAD continue to increase...
November 19, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27804896/investigating-cholesterol-metabolism-and-ageing-using-a-systems-biology-approach
#4
A E Morgan, K M Mooney, S J Wilkinson, N A Pickles, M T Mc Auley
CVD accounted for 27 % of all deaths in the UK in 2014, and was responsible for 1·7 million hospital admissions in 2013/2014. This condition becomes increasingly prevalent with age, affecting 34·1 and 29·8 % of males and females over 75 years of age respectively in 2011. The dysregulation of cholesterol metabolism with age, often observed as a rise in LDL-cholesterol, has been associated with the pathogenesis of CVD. To compound this problem, it is estimated by 2050, 22 % of the world's population will be over 60 years of age, in culmination with a growing resistance and intolerance to pre-existing cholesterol regulating drugs such as statins...
November 2, 2016: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/27798912/cx43-expression-in-colonic-adenomas-and-surrounding-mucosa-is-a-marker-of-malignant-potential
#5
Alen Bišćanin, Neven Ljubičić, Marko Boban, Drinko Baličević, Ivana Pavić, Mirela Maver Bišćanin, Ivan Budimir, Zdravko Dorosulic, Marko Duvnjak
BACKGROUND/AIM: Colorectal cancer is a major public health problem. The adenoma-carcinoma sequence offers potential for screening and surveillance. We tested the clinical behavior and diagnostic utility of connexin 43 (CX43) in connection with pathohistological risk. PATIENTS AND METHODS: Immunohistochemical expression of CX43 in colonic adenomas and surrounding mucosa from 87 patients was determined. RESULTS: CX43 expression was higher in mucosa surrounding adenomas with high-grade dysplasia (p=0...
October 2016: Anticancer Research
https://www.readbyqxmd.com/read/27780801/persistent-user-bias-in-case-crossover-studies-in-pharmacoepidemiology
#6
Jesper Hallas, Anton Pottegård, Shirley Wang, Sebastian Schneeweiss, Joshua J Gagne
Studying the effect of chronic medication exposure by means of a case-crossover design may result in an upward-biased odds ratio. In this study, our aim was to assess the occurrence of this bias and to evaluate whether it is remedied by including a control group (the case-time-control design). Using Danish data resources from 1995-2012, we conducted case-crossover and case-time-control analyses for 3 medications (statins, insulin, and thyroxine) in relation to 3 outcomes (retinal detachment, wrist fracture, and ischemic stroke), all with assumed null associations...
October 25, 2016: American Journal of Epidemiology
https://www.readbyqxmd.com/read/27747681/mood-personality-and-behavior-changes-during-treatment-with-statins-a-case-series
#7
Stephanie Cham, Hayley J Koslik, Beatrice A Golomb
Psychiatric adverse drug reactions (ADRs) have been reported with statin use, but the literature regarding statin-associated mood/behavioral changes remains limited. We sought to elicit information germane to natural history and characteristics of central nervous system/behavioral changes in apparent connection with statin and/or cholesterol-lowering drug use, and delineate mechanisms that may bear on an association. Participants (and/or proxies) self-referred with behavioral and/or mood changes in apparent association with statins completed a survey eliciting cholesterol-lowering drug history, character and impact of behavioral/mood effect, time-course of onset and recovery in relation to drug use/modification, co-occurrence of recognized statin-associated ADRs, and factors relevant to ADR causality determination...
December 2016: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/27734263/statin-attenuates-cell-proliferative-ability-via-taz-wwtr1-in-hepatocellular-carcinoma
#8
Takaaki Higashi, Hiromitsu Hayashi, Yuki Kitano, Kensuke Yamamura, Takayoshi Kaida, Kota Arima, Katsunobu Taki, Shigeki Nakagawa, Hirohisa Okabe, Hidetoshi Nitta, Katsunori Imai, Daisuke Hashimoto, Akira Chikamoto, Toru Beppu, Hideo Baba
Diabetes and obesity are associated with non-alcoholic steatohepatitis and an increased incidence of hepatocellular carcinoma (HCC). TAZ and YAP are equivalently placed downstream effectors of the Hippo pathway with oncogenic roles in human cancers. Statins are commonly used to patients with metabolic problems as hypercholesterolemia. Statins also have anti-cancer properties, and the cross-talk between mevalonate pathway and Hippo pathway was known. The aim of this study is to confirm the statin's anti-cancer effects on HCC cells and its survival benefits in HCC patients with curative surgery...
November 2016: Medical Oncology
https://www.readbyqxmd.com/read/27618753/esophageal-adenocarcinoma-screening-surveillance-and-management
#9
Nabil M Mansour, Shawn S Groth, Sharmila Anandasabapathy
Esophageal adenocarcinoma (EAC) is a growing problem with a rapidly rising incidence. Risk factors include gastroesophageal reflux disease, central obesity, and smoking. The prognosis of EAC remains poor because it is usually diagnosed late, and many efforts have been made to improve prevention, early detection, and treatment. Acid suppression, nonsteroidal antiinflammatory drugs (NSAIDs), and statins may play a role in chemoprevention. Screening for Barrett's esophagus (BE), the only known precursor lesion of EAC, is indicated for individuals with increased risk...
August 31, 2016: Annual Review of Medicine
https://www.readbyqxmd.com/read/27565837/ambulatory-cardiology-network-in-greece-clinical-and-therapeutic-implications-in-the-outpatient-setting-the-teve-ssf-study
#10
Konstantinos E Panagiotopoulos, Eleni E Panagiotopoulou, Konstantinos Katsaros, Georgios Noikokirakis, Maria Mpouziou, Angeliki Stamelou, Savvas Toumanidis
BACKGROUND: Community based registries are particularly valuable tools to Preventive Cardiology as they summarize epidemiological data of ischemic heart disease risk factors, medications and lifestyle characteristics. METHODS: We enrolled 1191 patients, from an outpatient community based cardiology network, dedicated to cover medically, office based professionals. We recorded demographic and lifestyle characteristics, risk factors for ischemic heart disease, all clinical entities diagnosed and therapies which were prescribed for hypertension and lipid disorders specifically...
November 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27562773/can-treatment-with-statins-have-a-negative-influence-on-the-tolerance-of-mandibular-advancement-devices
#11
Mónica González, Emilio Macias-Escalada, Juan Cobo, Maria Pilar Fernández Mondragón, Gerardo Gómez-Moreno, Marian Martínez-Martínez, Felix de Carlos
BACKGROUND: Statins are considered the most effective drugs used in the treatment of dyslipidemias. Some of their adverse effects are related to muscle problems. Myalgias produced by statins appear more often during exercise. Mandibular advancement devices (MAD) force the propulsory and elevatory musculature of the mandible to exercise by making the jaw move forward. The aim of this study is to evaluate the incidence of muscular side effects (referred, spontaneous, or under palpation pain, myofascial pain, mandibular rigidity and fatigue, tension and sensitivity of the masticatory muscles) in a group of patients with a diagnosis of obstructive sleep apnea being treated with MAD...
August 25, 2016: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/27549378/cholesterol-lowering-therapy-treat-to-target-or-reduce-the-global-risk-the-unresolved-problem-of-residual-risk
#12
Giulia Bruzzone, Giorgia Corbelli, Paola Belci, Annalaura Cremonini, Aldo Pende, Livia Pisciotta
BACKGROUND: Atherosclerotic Cardiovascular Disease (ASCVD) is the first cause of death in Western Countries. Several risk factors contribute to generate atherosclerosis and the preventive therapeutic approaches, in particular statin therapy, reduce the mortality. However, the residual risk in statin treated patients remains significant, despite reaching the low density lipoproteins cholesterol (LDL-C) goals. METHODS: we reviewed the literature published in PUB-MED to discuss the role of residual dyslipidemia in particular high density lipoprotein cholesterol (HDL-C), triglycerides (TGs) and lipoprotein(a) [Lp(a)], genetic factors, suboptimal implementation of lifestyle therapy, mood disorders associated to low compliance to application of evidence-based therapies or related to ASCVD...
August 22, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27535257/tendon-homeostasis-in-hypercholesterolemia
#13
Louis J Soslowsky, George W Fryhofer
Hypercholesterolemia is a serious health problem that is associated not only with heart disease, but also tendon pathology. In high cholesterol environments (e.g. familial hyperlipidemia), lipids accumulate within the tendon extracellular matrix and form deposits called xanthomas. Lipid-related changes are known to affect several tendon mechanical properties, including stiffness and modulus, in uninjured and injured tendons, alike. Mechanisms to explain these cholesterol-related changes are multiple, including alterations in tenocyte gene and protein expression, matrix turnover, tissue vascularity, and cytokine production...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27504306/a-retrospective-study-of-the-treatment-outcome-of-drug-therapies-used-in-heart-failure-patients-with-associated-co-morbidities-in-a-tertiary-care-hospital
#14
Harish Thanusubramanian, Meena Kumari Kamal Kishore, Ranjan Shetty, Mohan Babu Amberkar
INTRODUCTION: Heart failure is one of the most common heart problems seen in the Indian population. There are various drugs used to prevent further progression of the disease. In India, there are few studies in relation to treatment outcome in a tertiary care hospital. AIM: To study the treatment outcome of drug therapies used in heart failure patients with associated co-morbidities in a tertiary care hospital. MATERIALS AND METHODS: This was an observational study conducted on 250 patients with heart failure...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27497504/statin-intolerance-a-literature-review-and-management-strategies
#15
David R Saxon, Robert H Eckel
Statin intolerance is a commonly encountered clinical problem for which useful management strategies exist. Although many patients report statin-related muscle symptoms, studies indicate that the majority of these patients can tolerate a statin upon re-challenge. Alternative statin dosing strategies are an effective way to modify and reintroduce statin therapy for patients reporting adverse symptoms. Correction of vitamin D deficiency and hypothyroidism may improve statin tolerability in some patients. CoQ10 supplementation has been found to be of no benefit for statin-related muscle symptoms in most recent clinical trials...
September 2016: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/27496827/statins-in-the-management-of-pediatric-dyslipidemia
#16
Joyce L Ross
Hypercholesterolemia is a major concern in the USA, with studies identifying children as young as 2years old with early-stage atherosclerosis. Genetics play a major role in the dyslipidemia of children, but other factors, such as diet and lack of physical activity, confound the problem. Familial hypercholesterolemia (FH) is a genetic condition that causes lifelong elevations in low-density lipoprotein cholesterol (LDL-C). The heterozygous form of the disease affects around 1 in 200 people, and the homozygous form of the disease affects around 1 in 160,000-300,000 people...
November 2016: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/27439304/statin-centric-versus-low-density-lipoprotein-centric-approach-for-atherosclerotic-cardiovascular-disease-prevention-a-singapore-perspective
#17
Peter Yan, Eng Kiat Kevin Tan, Jason Chon Jun Choo, Choon Fong Stanley Liew, Titus Lau, David D Waters
The link between cholesterol levels and atherosclerotic cardiovascular disease (ASCVD) is well-established. In Singapore, there is an increasing prevalence of risk factors for ASCVD. Like many Asian countries, Singapore's population is rapidly ageing and increasingly sedentary, which predisposes individuals to chronic health problems. Current international and local guidelines recommend statin therapy for the primary and secondary prevention of ASCVD. However, despite the effectiveness of statin therapy, some studies have highlighted that Asian patients with cardiovascular disease are not achieving target lipid goals...
July 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/27430348/rhabdomyolysis-caused-by-the-moderate-cyp3a4-inhibitor-fluconazole-in-a-patient-on-stable-atorvastatin-therapy-a-case-report-and-literature-review
#18
S-H Hsiao, H-J Chang, T-H Hsieh, S-M Kao, P-Y Yeh, T-J Wu
WHAT IS KNOWN AND OBJECTIVE: Rhabdomyolysis is a severe potential adverse drug reaction of statin therapy. We report a case of rhabdomyolysis due to drug-drug interaction (DDI) between atorvastatin and fluconazole and review the literature. CASE SUMMARY: A 70-year-old woman received atorvastatin for hyperlipidaemia without any problem for 4 years. When intravenous fluconazole was added for treating a fungal infection, rhabdomyolysis developed 2 weeks later. Removal of atorvastatin led to the resolution of her rhabdomyolysis...
October 2016: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/27353261/discontinuation-and-restarting-in-patients-on-statin-treatment-prospective-open-cohort-study-using-a-primary-care-database
#19
Yana Vinogradova, Carol Coupland, Peter Brindle, Julia Hippisley-Cox
OBJECTIVES:  To estimate rates of discontinuation and restarting of statins, and to identify patient characteristics associated with either discontinuation or restarting. DESIGN:  Prospective open cohort study. SETTING:  664 general practices contributing to the Clinical Practice Research Datalink in the United Kingdom. Data extracted in October 2014. PARTICIPANTS:  Incident statin users aged 25-84 years identified between January 2002 and September 2013...
2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27349447/statins-and-alkylphospholipids-as-new-anticancer-agents-targeting-lipid-metabolism
#20
Sonia Apostolova, Reneta Toshkova, Albena Momchilova, Rumiana Tzoneva
The partial efficacy and high toxicity of the current anticancer chemotherapeutics as well as the development of multiple drug resistance are major problems in cancer therapy. Therefore, there is an emergency need for the development of novel well-tolerated anticancer agents with different mode of action that could be successfully used in combination with other drugs as an adjuvant therapy. The inhibition of intracellular signaling pathways associated with cancer growth and invasiveness is a main therapeutic approach in cancer treatment...
June 23, 2016: Anti-cancer Agents in Medicinal Chemistry
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