keyword
https://read.qxmd.com/read/38493723/notoginsenoside-r1-alleviates-cerebral-ischemia-reperfusion-injury-by-inhibiting-the-tlr4-myd88-nf-%C3%AE%C2%BAb-signaling-pathway-through-microbiota-gut-brain-axis
#21
JOURNAL ARTICLE
Shuxia Zhang, Qiuyan Chen, Meiqi Jin, Jiahui Ren, Xiao Sun, Zhixiu Zhang, Yun Luo, Xiaobo Sun
BACKGROUND: Ischemic stroke (IS) ranks as the second common cause of death worldwide. However, a narrow thrombolysis timeframe and ischemia-reperfusion (I/R) injury limits patient recovery. Moreover, anticoagulation and antithrombotic drugs do not meet the clinical requirements. Studies have demonstrated close communication between the brain and gut microbiota in IS. Notoginsenoside R1 (NG-R1), a significant component of the total saponins from Panax notoginseng, has been demonstrated to be effective against cerebral I/R injury...
March 11, 2024: Phytomedicine
https://read.qxmd.com/read/38493721/anti-inflammatory-effects-of-quinolinyl-analog-of-resveratrol-targeting-tlr4-in-mcao-r-ischemic-stroke-rat-model
#22
JOURNAL ARTICLE
Libin Xu, Yan Mi, Qingqi Meng, Yeshu Liu, Feng Wang, Guijie Zhang, Yueyang Liu, Guoliang Chen, Yue Hou
BACKGROUND: Among adults, stroke is the main causes of mortality and permanent disability. Neuroinflammation is one of the main causes of stoke-mediated neuronal death. Our previous study revealed that (E)-5-(2-(Quinolin-4-yl) vinyl) benzene-1, 3-diol (RV01), a quinolinyl analog of resveratrol, inhibits microglia-induced neuroinflammation and safeguards neurons from inflammatory harm. The preventive role of RV01 in ischemic stroke and its underlying cellular mechanisms and molecular targets remain poorly understood...
January 8, 2024: Phytomedicine
https://read.qxmd.com/read/38493057/application-of-targeted-liposomes-based-salvianolic-acid-a-for-the-treatment-of-ischemic-stroke
#23
JOURNAL ARTICLE
Ming-Yan Yang, Yu Liu, Ya-Wen Yu, Bai-Fang Gong, Jian Ruan, Hua-Ying Fan
Novel therapeutics for the treatment of ischemic stroke remains to be the unmet clinical needs. Previous studies have indicated that salvianolic acid A (SAA) is a promising candidate for the treatment of the brain diseases. However, SAA has poor absolute bioavailability and does not efficiently cross the intact blood-brain barrier (BBB), which limit its efficacy. To this end we developed a brain-targeted liposomes for transporting SAA via the BBB by incorporating the liposomes to a transport receptor, insulin-like growth factor-1 receptor (IGF1R)...
March 15, 2024: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://read.qxmd.com/read/38492817/airway-stenting-for-liberation-from-positive-pressure-ventilation-in-patients-with-central-airway-obstruction-presenting-with-acute-respiratory-failure
#24
JOURNAL ARTICLE
Bertin D Salguero, Abhinav Agrawal, Viren Kaul, Christian M Lo Cascio, Greta Joy, Matsuo So, Rohit Munagala, Timothy Harkin, Udit Chaddha
BACKGROUND: Central airway obstruction (CAO) can lead to acute respiratory failure (RF) necessitating positive pressure ventilation (PPV). The efficacy of airway stenting to aid liberation from PPV in patients with severe acute RF has been scarcely published. We present a systematic review and our recent experience. METHODS: A systematic review of PubMed was performed, and a retrospective review of cases performed at our two institutions from 2018 to 2022 in adult patients who needed stent insertion for extrinsic or mixed CAO complicated by RF necessitating PPV...
March 14, 2024: Respiratory Medicine
https://read.qxmd.com/read/38491167/ca-2-oscillation-in-vascular-smooth-muscle-cells-control-myogenic-spontaneous-vasomotion-and-counteract-post-ischemic-no-reflow
#25
JOURNAL ARTICLE
Jinze Li, Yiyi Zhang, Dongdong Zhang, Wentao Wang, Huiqi Xie, Jiayu Ruan, Yuxiao Jin, Tingbo Li, Xuzhao Li, Bingrui Zhao, Xiaoxuan Zhang, Jiayi Lin, Hongjun Shi, Jie-Min Jia
Ischemic stroke produces the highest adult disability. Despite successful recanalization, no-reflow, or the futile restoration of the cerebral perfusion after ischemia, is a major cause of brain lesion expansion. However, the vascular mechanism underlying this hypoperfusion is largely unknown, and no approach is available to actively promote optimal reperfusion to treat no-reflow. Here, by combining two-photon laser scanning microscopy (2PLSM) and a mouse middle cerebral arteriolar occlusion (MCAO) model, we find myogenic vasomotion deficits correlated with post-ischemic cerebral circulation interruptions and no-reflow...
March 15, 2024: Communications Biology
https://read.qxmd.com/read/38491106/decreased-levels-of-hydrogen-sulfide-in-the-hypothalamic-paraventricular-nucleus-contribute-to-sympathetic-hyperactivity-induced-by-cerebral-infarction
#26
JOURNAL ARTICLE
Jianping Sun, Yuxin Miao, Ping Wang, Qi Guo, Danyang Tian, Hongmei Xue, Lin Xiao, Meng Xu, Ru Wang, Xiangjian Zhang, Sheng Jin, Xu Teng, Yuming Wu
Paroxysmal sympathetic hyperactivity (PSH) is a common clinical feature secondary to ischemic stroke (IS), but its mechanism is poorly understood. We aimed to investigate the role of H2 S in the pathogenesis of PSH. IS patients were divided into malignant (MCI) and non-malignant cerebral infarction (NMCI) group. IS in rats was induced by the right middle cerebral artery occlusion (MCAO). H2 S donor (NaHS) or inhibitor (aminooxy-acetic acid, AOAA) were microinjected into the hypothalamic paraventricular nucleus (PVN)...
March 15, 2024: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://read.qxmd.com/read/38488999/experimental-ischemic-stroke-induces-secondary-bihemispheric-white-matter-degeneration-and-long-term-cognitive-impairment
#27
JOURNAL ARTICLE
Ran Liu, Raymond Berry, Linshu Wang, Kiran Chaudhari, Ali Winters, Yuanhong Sun, Claire Caballero, Hannah Ampofo, Yiwei Shi, Bibek Thata, Luis Colon-Perez, Nathalie Sumien, Shao-Hua Yang
Clinical studies have identified widespread white matter degeneration in ischemic stroke patients. However, contemporary research in stroke has predominately focused on the infarct and periinfarct penumbra regions. The involvement of white matter degeneration after ischemic stroke and its contribution to post-stroke cognitive impairment and dementia (PSCID) has remained less explored in experimental models. In this study, we examined the progression of locomotor and cognitive function up to 4 months after inducing ischemic stroke by middle cerebral artery occlusion in young adult rats...
March 15, 2024: Translational Stroke Research
https://read.qxmd.com/read/38488455/salidroside-directly-activates-hsc70-revealing-a-new-role-for-hsc70-in-bdnf-signalling-and-neurogenesis-after-cerebral-ischemia
#28
JOURNAL ARTICLE
Wenfang Lai, Rui Luo, Yuheng Tang, Zhengshuang Yu, Binbin Zhou, Zelin Yang, John Brown, Guizhu Hong
Salidroside, a principal bioactive component of Rhodiola crenulata, is neuroprotective across a wide time window in stroke models. We investigated whether salidroside induced neurogenesis after cerebral ischemia and aimed to identify its primary molecular targets. Rats, subjected to transient 2 h of middle cerebral artery occlusion (MCAO), received intraperitoneal vehicle or salidroside ± intracerebroventricular HSC70 inhibitor VER155008 or TrkB inhibitor ANA-12 for up to 7 days. MRI, behavioural tests, immunofluorescent staining and western blotting measured effects of salidroside...
March 15, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38488446/erythropoietin-derived-peptide-ara290-mediates-brain-tissue-protection-through-the-%C3%AE-common-receptor-in-mice-with-cerebral-ischemic-stroke
#29
JOURNAL ARTICLE
Rong-Liang Wang, Zhen-Hong Yang, Yu-You Huang, Yue Hu, Yi-Lin Wang, Feng Yan, Yang-Min Zheng, Zi-Ping Han, Jun-Fen Fan, Zhen Tao, Hai-Ping Zhao, Si-Jie Li, Yu-Min Luo
AIM: To explore the neuroprotective effects of ARA290 and the role of β-common receptor (βCR) in a mouse model of middle cerebral artery occlusion (MCAO). METHODS: This study included male C57BL/6J mice that underwent MCAO and reperfusion. The neuroprotective effect of ARA290 on MCAO-induced brain injury was investigated using neurological function tests (Longa and modified neurological severity score). Cerebral infarction was examined by 2, 3, 5-triphenyl tetrazolium chloride staining, neuronal apoptosis was assessed by immunofluorescence staining, blood parameters were measured using a flow cytometry-based automated hematology analyzer, liquid chromatography with tandem mass spectrometry was used to identify the serum metabolomics signature, inflammatory cytokines and liver index were detected by commercially available kits, and the protein levels of the erythropoietin (EPO) receptor and βCR were measured by western blot...
March 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38482520/recombinant-human-heavy-chain-ferritin-nanoparticles-serve-as-ros-scavengers-for-the-treatment-of-ischemic-stroke
#30
JOURNAL ARTICLE
Mi Qi, Yajuan Cheng, Ke Liu, Jingxing Cai, Tianyu Liu, Xiaoying Wu, Huili Tang, He Huang, Qinbiao Chen, Xiaoguang Zhou
PURPOSE: Ischemic stroke is a high-incidence disease that threatens human well-being. The potent neuroprotective effects render reactive oxygen species (ROS) scavengers potential agents for acute ischemic stroke therapy. Challenges such as inadequate permeability across the blood-brain barrier (BBB), limited half-life, and adverse effects hinder the widespread utilization of small molecule and inorganic ROS scavengers. Thus, there is an urgent demand for efficacious neuroprotective agents targeting ischemic stroke...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38478127/induced-mesenchymal-stem-cells-small-extracellular-vesicles-alleviate-post-stroke-cognitive-impairment-by-rejuvenating-senescence-of-neural-stem-cells
#31
JOURNAL ARTICLE
Jiayuan Liu, Li Peng, Lingwei He, Tianyue Yin, Yuhao Du, Mengmeng Yang, Ping Wu, Jun Li, Jiangbing Cao, Hongrui Zhu, Sheng Wang
Ischemic stroke is typified by hypoxia and a cascade of pathophysiological events, including metabolic dysfunction, ionic dysregulation, excitotoxicity, inflammatory infiltration, and oxidative stress. These ultimately result in neuronal apoptosis or necrosis with constrained neuroregenerative capabilities. In this study, neural stem cells (NSCs) under conditions of oxygen-glucose deprivation (OGD) in vitro and following middle cerebral artery occlusion (MCAO) in vivo were explored. Transcriptome sequencing revealed a decline in NSC differentiation and neurogenesis after OGD exposure, which was related to cellular senescence...
March 13, 2024: Journal of Molecular Neuroscience: MN
https://read.qxmd.com/read/38474179/the-optimization-design-of-macrophage-membrane-camouflaging-liposomes-for-alleviating-ischemic-stroke-injury-through-intranasal-delivery
#32
JOURNAL ARTICLE
Tianshu Liu, Yan Wang, Mengfan Zhang, Jin Zhang, Naijin Kang, Linlin Zheng, Zhiying Ding
Ischemic stroke is associated with a high mortality rate, and effective treatment strategies are currently lacking. In this study, we aimed to develop a novel nano delivery system to treat ischemic stroke via intranasal administration. A three-factor Box-Behnken experimental design was used to optimize the formulation of liposomes co-loaded with Panax notoginseng saponins (PNSs) and Ginsenoside Rg3 (Rg3) (Lip-Rg3/PNS). Macrophage membranes were coated onto the surface of the optimized liposomes to target the ischemic site of the brain...
March 2, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38469210/4-hydroxysesamin-a-modified-natural-compound-attenuates-neuronal-apoptosis-after-ischemic-stroke-via-inhibiting-mapk-pathway
#33
JOURNAL ARTICLE
Lina Wang, Zhenzhen Qu, Qian Sun, Zhuofeng Mao, Peipei Si, Weiping Wang
BACKGROUND: The 4-hydroxysesamin (4-HS, a di-tetrahydrofuran lignin) is a modified sesamin that was prepared in the laboratory. This preclinical study was designed to preliminarily investigate the neuroprotective properties of 4-HS. METHODS: In vitro, neuronal injury and inflammation were simulated by oxygen-glucose deprivation and lipopolysaccharide (LPS) exposure in mouse hippocampal neuronal HT22 cell line, and treated with 4-HS and/or metformin (MET, MAPK pathway activator for exploring mechanism)...
2024: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/38468566/inhibition-of-leukocyte-migration-after-ischemic-stroke-by-ve-cadherin-mutation-in-a-mouse-model-leads-to-reduced-infarct-volumes-and-improved-motor-skills
#34
JOURNAL ARTICLE
Mailin Hannah Marie Koecke, Jan-Kolja Strecker, Frederike Anne Straeten, Carolin Beuker, Jens Minnerup, Antje Schmidt-Pogoda, Anna-Lena Börsch
AIMS: To distinguish between the genuine cellular impact of the ischemic cascade by leukocytes and unspecific effects of edema and humoral components, two knock-in mouse lines were utilized. Mouse lines Y731F and Y685F possess point mutations in VE-cadherin, which lead to a selective inhibition of transendothelial leukocyte migration or impaired vascular permeability. METHODS: Ischemic stroke was induced by a model of middle cerebral artery occlusion. Analysis contained structural outcomes (infarct volume and extent of brain edema), functional outcomes (survival analysis, rotarod test, and neuroscore), and the extent and spatial distribution of leukocyte migration (heatmaps and fluorescence-activated cell sorting (FACS) analysis)...
March 2024: Brain and Behavior
https://read.qxmd.com/read/38468466/dihydroergotamine-protects-against-ischemic-stroke-by-modulating-microglial-macrophage-polarization-and-inhibiting-inflammation-in-mice
#35
JOURNAL ARTICLE
Yangmin Zheng, Yue Hu, Feng Yan, Rongliang Wang, Zhen Tao, Junfen Fan, Ziping Han, Haiping Zhao, Ping Liu, Wei Zhuang, Yumin Luo
OBJECTIVES: The search for drugs that can protect the brain tissue and reduce nerve damage in acute ischemic stroke has emerged as a research hotspot. We investigated the potential protective effects and mechanisms of action of dihydroergotamine against ischemic stroke. METHODS: C57BL/6 mice were subjected to middle cerebral artery occlusion (MCAO), and dihydroergotamine at a dose of 10 mg/kg/day was intraperitoneally injected for 14 days. Adhesive removal and beam walking tests were conducted 1, 3, 5, 7, 10, and 14 days after MCAO surgery...
March 11, 2024: Neurological Research
https://read.qxmd.com/read/38455957/dl-3-n-butylphthalide-attenuates-cerebral-ischemia-reperfusion-injury-in-mice-through-ampk-mediated-mitochondrial-fusion
#36
JOURNAL ARTICLE
Ting Zhu, Shanshan Dong, Na Qin, Rujuan Liu, Liuliu Shi, Qi Wan
Introduction: NBP is a compound isolated from celery seeds, which was approved by the National Medical Products Administration in 2002 for clinical treatment of ischemic stroke. However, in brain ischemia/reperfusion (I/R) injury, the related research on mitochondrial dynamics and its mechanism of action of NBP still need to be further studied. The aim of this study was to assess NBP on cerebral pathology in ischemic stroke in vivo , with a specific focus on the molecular mechanisms of how NBP promotes mitochondrial fusion...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38452845/formononetin-alleviates-cerebral-ischemia-reperfusion-injury-in-rats-by-targeting-the-parp-1-parg-iduna-signaling-pathway
#37
JOURNAL ARTICLE
Jie Luo, Youde Cai, Dingling Wei, Liping Cao, Qiansong He, Yuanhua Wu
Formononetin has been demonstrated to protect against cerebral ischemia-reperfusion injury, however its mechanism has to be further researched. This study examined the effect of formononetin on cerebral ischemia-reperfusion injury in rats using the PARP-1/PARG/Iduna signaling pathway. In male SD rats, a model of cerebral ischemia-reperfusion injury was developed. Animals were randomly assigned to one of eight groups: Sham operation, Sham operation + formononetin, MCAO, MCAO + formononetin, PARP inhibitor (PJ34) + MCAO, formononetin + PJ34 + MCAO, PARG inhibitor (Ethacridine lactate) + MCAO, and ethacridine lactate + formononetin...
March 5, 2024: Brain Research
https://read.qxmd.com/read/38452414/fisetin-alleviates-cerebral-ischemia-reperfusion-injury-by-regulating-sirt1-foxc1-ubqln1-pathway-mediated-proteostasis
#38
JOURNAL ARTICLE
Xunhu Gu, Yuqin Xie, Qian Cao, Zhuo Hou, Yan Zhang, Wei Wang
BACKGROUND: Cerebral ischemia/reperfusion injury (IRI) is pathologically associated with protein damage. The flavonoid fisetin has good therapeutic effects on cerebral IRI. However, the role of fisetin in regulating protein damage during cerebral IRI development remains unclear. This study investigated the pharmacological effects of fisetin on protein damage during cerebral IRI progression and defined the underlying mechanism of action. METHODS: In vivo and in vitro models of cerebral IRI were established by middle cerebral artery occlusion/reperfusion (MACO/R) and oxygen-glucose deprivation/reperfusion (OGD/R) treatment, respectively...
March 6, 2024: International Immunopharmacology
https://read.qxmd.com/read/38448479/bioinformatics-analysis-and-experimental-validation-revealed-that-paeoniflorigenone-effectively-mitigates-cerebral-ischemic-stroke-by-suppressing-oxidative-stress-and-inflammation
#39
JOURNAL ARTICLE
Zhiyan Wu, Xingrong Tang
Inflammation and oxidative stress are becoming more recognized as risk factors for ischemic stroke. Paeoniflorigenone (PA) has diverse pharmacological effects that include anti-inflammatory and antioxidant properties. However, the specific mechanisms by which PA affects cerebral ischemic stroke have not been studied. Our objective was to investigate the potential targets and mechanisms of PA in preventing cerebral ischemic stroke. We obtained the potential targets of PA from the SwissTargetPrediction, Super-PRED, and SEA Search Server databases...
March 7, 2024: Scientific Reports
https://read.qxmd.com/read/38444306/a-neutrophil-hijacking-nanoplatform-reprograming-netosis-for-targeted-microglia-polarizing-mediated-ischemic-stroke-treatment
#40
JOURNAL ARTICLE
Na Yin, Wenya Wang, Fei Pei, Yuzhen Zhao, Changhua Liu, Mingming Guo, Kaixiang Zhang, Zhenzhong Zhang, Jinjin Shi, Yun Zhang, Zhi-Hao Wang, Junjie Liu
Precise and efficient regulation of microglia is vital for ischemic stroke therapy and prognosis. The infiltration of neutrophils into the brain provides opportunities for regulatory drugs across the blood-brain barrier, while hindered by neutrophil extracellular traps (NETs) and targeted delivery of intracerebral drugs to microglia. This study reports an efficient neutrophil hijacking nanoplatform (referred to as APTS) for targeted A151 (a telomerase repeat sequence) delivery to microglia without the generation of NETs...
March 5, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
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