keyword
MENU ▼
Read by QxMD icon Read
search

mcao

keyword
https://www.readbyqxmd.com/read/28343073/breviscapine-confers-a-neuroprotective-efficacy-against-transient-focal-cerebral-ischemia-by-attenuating-neuronal-and-astrocytic-autophagy-in-the-penumbra
#1
Zhang Pengyue, Guo Tao, He Hongyun, Yang Liqiang, Deng Yihao
Breviscapine is a flavonoid derived from a traditional Chinese herb Erigerin breviscapus (Vant.) Hand-Mazz, and has been extensively used in clinical treatment for cerebral stroke in China, but the underlying pharmacological mechanisms are still unclear. In present study, we investigated whether breviscapine could confer a neuroprotection against cerebral ischemia injury by targeting autophagy mechanisms. A cerebral stroke model in Sprague-Dawley rats was prepared by middle cerebral artery occlusion (MCAO), rats were then randomly divided into 5 groups: MCAO+Bre group, rats were treated with breviscapine; MCAO+Tat-Beclin-1 group, animals were administrated with specific autophagy inducer Tat-Beclin-1; MCAO+Bre+Tat-Beclin-1 group, rats were treated with both breviscapine and Tat-Beclin-1, MCAO+saline group, rats received the same volume of physiological saline, and Sham surgery group...
March 23, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28336567/sox9-is-an-astrocyte-specific-nuclear-marker-in-the-adult-brain-outside-the-neurogenic-regions
#2
Wei Sun, Adam Cornwell, Jiashu Li, Sisi Peng, M Joana Osorio, Nadia Aalling Su Wanga, Abdellatif Benraiss, Nanhong Lou, Steven A Goldman, Maiken Nedergaard
Astrocytes have in recent years become the focus of intense experimental interest, yet markers for their definitive identification remain both scarce and imperfect. Astrocytes may be recognized as such by their expression of glial fibrillary acidic protein (GFAP), glutamine synthetase (GS), glutamate transporter 1 (GLT1)quaporin-4 (AQP4)ldehyde dehydrogenase 1 family member L1 (ALDH1L1)nd other proteins. Yet these proteins may all be regulated both developmentally and functionally, restricting their utility...
March 23, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28320070/dexpramipexole-improves-bioenergetics-and-outcome-in-experimental-stroke
#3
Mirko Muzzi, Elisabetta Gerace, Daniela Buonvicino, Elisabetta Coppi, Francesco Resta, Laura Formentini, Riccardo Zecchi, Laura Tigli, Daniele Guasti, Martina Ferri, Emidio Camaioni, Alessio Masi, Domenico E Pellegrini-Giampietro, Guido Mannaioni, Daniele Bani, Anna M Pugliese, Alberto Chiarugi
BACKGROUND AND PURPOSE: To investigate the effects of dexpramipexole, a drug recently tested in ALS patients able to bind F1Fo ATP synthase and increase mitochondrial ATP production, on experimental ischemic brain injury. EXPERIMENTAL APPROACH: The effects of dexpramipexole on bioenergetics, Ca(2+) fluxes, electrophysiological functions and death were evaluated in primary neural cultures and hippocampal slices exposed to oxygen-glucose deprivation (OGD). The drug's impact on infarct volumes and neurological functions was also evaluated in mice subjected to proximal or distal MCAo...
March 20, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28315868/cerebellar-fastigial-nucleus-electrical-stimulation-alleviates-depressive-like-behaviors-in-post-stroke-depression-rat-model-and-potential-mechanisms
#4
Lei Zhang, Mingkui Zhao, Ru-Bo Sui
OBJECTIVE: To identify the molecular mechanism of post-stroke depression (PSD), and observe the therapeutic effects of cerebellar fastigial nucleus electrical stimulation (FNS) on the behaviors and regional cerebral blood flow (rCBF) in a PSD rat model. METHODS: Healthy SD rats were randomly divided into four groups (sham, stroke, post-stroke depress and FNS group). Sham group (n = 6) underwent sham operation. The other three groups (n = 6*3) underwent MCAO. Rats were examined twice a week in open filed test...
March 16, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28300551/role-of-caveolin-1-vascular-endothelial-growth-factor-pathway-in-basic-fibroblast-growth-factor-induced-angiogenesis-and-neurogenesis-after-treadmill-training-following-focal-cerebral-ischemia-in-rats
#5
Qiongyi Pang, Huimei Zhang, Zhenzhen Chen, Yudan Wu, Min Yidian Bai Liu, Yun Zhao, Fengxia Tu, Chan Liu, Xiang Chen
Exercise is known to aid functional recovery following ischemia, though the mechanisms responsible for the beneficial effects of exercise on recovery from ischemic stroke are not fully understood. Basic fibroblast growth factor (bFGF) contributes to angiogenesis and promotes neurologic functional recovery after stroke. The present study aimed to investigate the possible mechanisms whereby treadmill exercise ameliorated impaired angiogenesis and neurogenesis following transient cerebral ischemia in middle cerebral artery occlusion (MCAO) rats...
March 11, 2017: Brain Research
https://www.readbyqxmd.com/read/28288870/tia-model-is-attainable-in-wistar-rats-by-intraluminal-occlusion-of-the-mca-for-10-min-or-shorter
#6
A Durukan Tolvanen, E Tatlisumak, E Pedrono, U Abo-Ramadan, T Tatlisumak
Transient ischemic attack (TIA) has received only little attention in the experimental research field. Recently, we introduced a TIA model for mice, and here we set similar principles for simulating this human condition in Wistar rats. In the model: 1) transient nature of the event is ensured, and 2) 24 h after the event animals are free from any sensorimotor deficit and from any detectable lesion by magnetic resonance imaging (MRI). Animals experienced varying durations of ischemia (5, 10, 12.5, 15, 25, and-30 min, n=6-8 per group) by intraluminal middle cerebral artery occlusion (MCAO)...
March 10, 2017: Brain Research
https://www.readbyqxmd.com/read/28278253/reduced-bone-formation-markers-and-altered-trabecular-and-cortical-bone-mineral-densities-of-non-paretic-femurs-observed-in-rats-with-ischemic-stroke-a-randomized-controlled-pilot-study
#7
Karen N Borschmann, Sarah S Rewell, Sandra Iuliano, Ali Ghasem-Zadeh, Rachel A Davey, Heidi Ho, Peta N Skeers, Julie Bernhardt, David W Howells
BACKGROUND: Immobility and neural damage likely contribute to accelerated bone loss after stroke, and subsequent heightened fracture risk in humans. OBJECTIVE: To investigate the skeletal effect of middle cerebral artery occlusion (MCAo) stroke in rats and examine its utility as a model of human post-stroke bone loss. METHODS: Twenty 15-week old spontaneously hypertensive male rats were randomized to MCAo or sham surgery controls. Primary outcome: group differences in trabecular bone volume fraction (BV/TV) measured by Micro-CT (10...
2017: PloS One
https://www.readbyqxmd.com/read/28272417/effects-of-the-tlr4-signaling-pathway-on-apoptosis-of-neuronal-cells-in-diabetes-mellitus-complicated-with-cerebral-infarction-in-a-rat-model
#8
Chao Li, Li-He Che, Tie-Feng Ji, Lei Shi, Jin-Lu Yu
This study aims to explore the effects of the TLR4 signaling pathway on the apoptosis of neuronal cells in rats with diabetes mellitus complicated with cerebral infarction (DMCI). A DMCI model was established with 40 Sprague Dawley rats, which were assigned into blank, sham, DM + middle cerebral artery occlusion (MCAO) and DM + MCAO + TAK242 groups. Superoxide dismutase (SOD) activity and malondialdehyde (MDA) content were measured. A TUNEL assay was applied for detecting cell apoptosis, and Western blotting was used for detecting the expression of TLR4, TNF-α, IL-1β and apoptosis-related proteins...
March 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28264448/paeoniflorin-attenuates-cerebral-ischemia-induced-injury-by-regulating-ca-2-camkii-creb-signaling-pathway
#9
Yuqin Zhang, Lifei Qiao, Wen Xu, Xiaoying Wang, Huang Li, Wei Xu, Kedan Chu, Yu Lin
Paeoniflorin (PF) is an active ingredient of Paeoniae Radix which possesses the neuroprotective effect. However, so far, the neuroprotective mechanism of PF has still not been fully uncovered. The Ca(2+)/Ca(2+)/calmodulin-dependent protein kinase II (CaMKII)/cAMP response element-binding (CREB) signaling pathway plays an important role in the intracellular signal transduction pathway involved in cell proliferation, cell survival, inflammation and metabolism. Herein, the neuroprotective roles of PF in the models of middle cerebral artery occlusion (MCAO) followed by reperfusion in rats and N-methyl-d-aspartic acid (NMDA)-induced excitotoxicity in primary hippocampal neurons were investigated...
February 27, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28257891/combined-metabolic-and-transcriptional-profiling-identifies-pentose-phosphate-pathway-activation-by-hsp27-phosphorylation-during-cerebral-ischemia
#10
Taichiro Imahori, Kohkichi Hosoda, Tomoaki Nakai, Yusuke Yamamoto, Yasuhiro Irino, Masakazu Shinohara, Naoko Sato, Takashi Sasayama, Kazuhiro Tanaka, Hiroaki Nagashima, Masaaki Kohta, Eiji Kohmura
The metabolic pathophysiology underlying ischemic stroke remains poorly understood. To gain insight into these mechanisms, we performed a comparative metabolic and transcriptional analysis of the effects of cerebral ischemia on the metabolism of the cerebral cortex using middle cerebral artery occlusion (MCAO) rat model. Metabolic profiling by gas-chromatography/mass-spectrometry analysis showed clear separation between the ischemia and control group. The decreases of fructose 6-phosphate and ribulose 5-phosphate suggested enhancement of the pentose phosphate pathway (PPP) during cerebral ischemia (120-min MCAO) without reperfusion...
March 6, 2017: Neuroscience
https://www.readbyqxmd.com/read/28257582/osthole-prevents-cerebral-ischemia-reperfusion-injury-via-notch-signaling-pathway
#11
Junhong Guan, Xiangtai Wei, Shengtao Qu, Tao Lv, Qiang Fu, Ye Yuan
Stroke is a common cerebrovascular disease in aged population with the second leading mortality and the leading cause of permanent disability, and the ischemic stroke is the primary form. Osthole is a coumarin derivative extracted from the fruits of Cnidium monnieri (Linn.) Cuss. In this study, we established the rat middle cerebral artery occlusion/reperfusion (MCAO/R) model in vivo, and found that MCAO/R caused cerebral infarction, hippocampus neuronal injury and apoptosis, and also activated the Notch 1 signaling pathway...
March 3, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28256152/neuroprotection-of-taurine-through-inhibition-of-12-15-lipoxygenase-pathway-in-cerebral-ischemia-of-rats
#12
Zhe Zhang, Rongbo Yu, Lei Cao
BACKGROUND: Cerebral ischemia exhibits a multiplicity of pathophysiological mechanisms. Taurine (Tau), an endogenous substance, possesses a number of cytoprotective properties. The aim of the present study was to examine the neuroprotective effect of Tau, through affecting 12/15 lipoxygenase (12/15-LOX) signal pathway in an acute permanent middle cerebral artery occlusion (MCAO) model of rats. METHODS: Sprague-Dawley rats were randomly divided into 3 groups (n = 10), namely the sham-operated group, MCAO group and Tau group...
March 3, 2017: Neurological Research
https://www.readbyqxmd.com/read/28255345/a-specific-dietary-intervention-to-restore-brain-structure-and-function-after-ischemic-stroke
#13
Maximilian Wiesmann, Bastian Zinnhardt, Dirk Reinhardt, Sarah Eligehausen, Lydia Wachsmuth, Sven Hermann, Pieter J Dederen, Marloes Hellwich, Michael T Kuhlmann, Laus M Broersen, Arend Heerschap, Andreas H Jacobs, Amanda J Kiliaan
Occlusion of the middle cerebral artery (MCAo) is among the most common causes of ischemic stroke in humans. Cerebral ischemia leads to brain lesions existing of an irreversibly injured core and an ischemic boundary zone, the penumbra, containing damaged but potentially salvageable tissue. Using a transient occlusion (30 min) of the middle cerebral artery (tMCAo) mouse model in this cross-institutional study we investigated the neurorestorative efficacy of a dietary approach (Fortasyn) comprising docosahexaenoic acid, eicosapentaenoic acid, uridine, choline, phospholipids, folic acid, vitamins B12, B6, C, and E, and selenium as therapeutic approach to counteract neuroinflammation and impairments of cerebral (structural+functional) connectivity, cerebral blood flow (CBF), and motor function...
2017: Theranostics
https://www.readbyqxmd.com/read/28251683/limb-remote-ischemic-postconditioning-induced-elevation-of-fibulin-5-confers-neuroprotection-to-rats-with-cerebral-ischemia-reperfusion-injury-activation-of-the-akt-pathway
#14
Wei Zhang, Ye Wang, Guorong Bi
Limb remote ischemic postconditioning (RIPostC) is an effective and well-acknowledged treatment for brain ischemia injury. The present study aimed to evaluate the role of fibulin-5 in the neuroprotection of RIPostC against cerebral ischemia/reperfusion (I/R) injury in rats. The middle cerebral artery occlusion (MCAO) model was established in rats and then RIPostC was carried out by 3 cycles of 10 min occlusion/10 min release of the bilateral femoral artery at the beginning of the reperfusion. To downregulate the fibulin-5 level, fibulin-5 siRNA was injected into the lateral ventricle 24 h before MCAO...
March 2, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28247188/diabetes-worsens-functional-outcomes-in-young-female-rats-comparison-of-stroke-models-tissue-plasminogen-activator-effects-and-sexes
#15
Weiguo Li, Rebecca Ward, John Paul Valenzuela, Guangkuo Dong, Susan C Fagan, Adviye Ergul
Diabetes worsens stroke outcome and increases the risk of hemorrhagic transformation (HT) after ischemic stroke, especially with tissue plasminogen activator (tPA) treatment. The widespread use of tPA is still limited by the fear of hemorrhagic transformation (HT), and underlying mechanisms are actively being pursued in preclinical studies. However, experimental models use a 10 times higher dose of tPA than the clinical dose (10 mg/kg) and mostly employ only male animals. In this translational study, we hypothesized that low-dose tPA will improve the functional recovery after the embolic stroke in both control and diabetic male and female animals...
March 1, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/28243167/effect-of-single-and-double-administration-of-human-umbilical-cord-blood-derived-mesenchymal-stem-cells-following-focal-cerebral-ischemia-in-rats
#16
Hyung Woo Park, Yona Kim, Jong Wook Chang, Yoon Sun Yang, Wonil Oh, Jae Min Lee, Hye Ran Park, Dong Gyu Kim, Sun Ha Paek
Stem cell therapies are administered during the acute phase of stroke to preserve the penumbral tissues from ischemic injury. However, the effect of repeated cell therapy during the acute phase remains unclear. In this study, we investigated and compared the functional outcome of single (two days post-injury) and repeated (two and nine days post-injury) treatment with human umbilical cord derived mesenchymal stem cells (hUCB-MSCs) after middle cerebral artery occlusion (MCAO). The rotarod and limb placement tests were utilized to investigate functional outcomes, while infarct volume and tissue damage were measured by immunofluorescent staining for neovascularization, neurogenesis, apoptosis, and inflammation in the penumbral zones...
February 2017: Experimental Neurobiology
https://www.readbyqxmd.com/read/28241639/solar-multi-conjugate-adaptive-optics-based-on-high-order-ground-layer-adaptive-optics-and-low-order-high-altitude-correction
#17
Lanqiang Zhang, Youming Guo, Changhui Rao
Multi-conjugate adaptive optics (MCAO) is the most promising technique currently developed to enlarge the corrected field of view of adaptive optics for astronomy. In this paper, we propose a new configuration of solar MCAO based on high order ground layer adaptive optics and low order high altitude correction, which result in a homogeneous correction effect in the whole field of view. An individual high order multiple direction Shack-Hartmann wavefront sensor is employed in the configuration to detect the ground layer turbulence for low altitude correction...
February 20, 2017: Optics Express
https://www.readbyqxmd.com/read/28237799/neuroprotective-effects-of-genistein-3-sodium-sulfonate-on-focal-cerebral-ischemia-in-rats
#18
Liangdong Li, Jinhua Xue, Ruizhen Liu, Xiao Li, Lijuan Lai, Jiali Xie, Zhihua Huang, Cheng Huang
In order to improve the poor water solubility of genistein (4',5,7-trihydroxyisoflavone), which is extracted from food sources such as tofu, soybeans, and kudzu, we sulfonated genistein to synthesize a relatively more water-soluble compound, namely genistein-3'-sodium sulfonate (GSS). Our previous studies demonstrate that GSS protects cortical neurons from injury induced by focal cerebral ischemia. However, the molecular mechanisms underlying this protective effect remain unclear. We aimed to investigate the protective effect and potential molecular mechanisms of action of GSS in rat glutamate-induced cortical neuron injury in vitro and middle cerebral artery occlusion (MCAO) in vivo models...
February 22, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28236616/nuclear-factor-kb-and-inhibitor-of-kb-acupuncture-protection-against-acute-focal-cerebral-ischemia-in-rodents
#19
Wei Huang, Zhongyu Zhou, Bijiang Wan, Guang Chen, Jia Li
Context • Acute, focal, cerebral ischemic stroke is a leading cause of morbidity and mortality worldwide. Acupuncture is an emerging alternative therapy for treatment of acute brain ischemia. Nevertheless, the precise mechanism underlying the neuroprotective effects of acupuncture has not been elucidated. Nuclear factor κB (NF-κB) and nuclear factor of κ light polypeptide gene enhancer in B cell inhibitor alpha (IκB-α) are involved in cerebral inflammation. However, the involvement of NF-κB and IκB-α in the protective effects of acupuncture on ischemic tolerance remains unknown...
February 27, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28236211/%C3%AE-caryophyllene-pretreatment-alleviates-focal-cerebral-ischemia-reperfusion-injury-by-activating-pi3k-akt-signaling-pathway
#20
Qian Zhang, Ruidi An, Xiaocui Tian, Mei Yang, Minghang Li, Jie Lou, Lu Xu, Zhi Dong
β-Caryophyllene (BCP) has been reported to be protective against focal cerebral ischemia-reperfusion (I/R) injury by its anti-oxidative and anti-inflammatory features. Recent study demonstrates that the BCP exhibits potential neuroprotection against I/R injury induced apoptosis, however, the mechanism remains unknown. Therefore, we investigate the underlying anti-apoptotic mechanism of BCP pretreatment in I/R injury. Sprague-Dawley rats (pretreated with BCP suspensions or solvent orally for 7 days) were subjected to transient Middle Cerebral Artery Occlusion (MCAO) for 90 min, followed by 24 h reperfusion...
February 24, 2017: Neurochemical Research
keyword
keyword
38350
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"