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nodular fasciitis

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https://www.readbyqxmd.com/read/28794344/papillary-thyroid-carcinoma-with-desmoid-type-fibromatosis-a-clinical-pathological-and-immunohistochemical-study-of-14-cases
#1
Nami Takada, Mitsuyoshi Hirokawa, Masahiro Ito, Aki Ito, Ayana Suzuki, Miyoko Higuchi, Seiji Kuma, Toshitetsu Hayashi, Masao Kishikawa, Shuichi Horikawa, Akira Miyauchi
Papillary thyroid carcinoma (PTC) with desmoid-type fibromatosis (DTF) is characterized by genetic alterations of the fibroblasts. However, PTC-DTF is extremely rare, and the reports on such cases have been sporadic. Immunohistochemical staining using the antibody for beta-catenin is useful in diagnosing the variant. This report aims to describe the clinical, pathological, and immunohistochemical findings in 14 cases of PTC-DTF and to clarify the diagnostic significance of the variant. The patients included 9 women and 5 men, with a mean age of 49...
August 10, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28752842/usp6-activation-in-nodular-fasciitis-by-promoter-swapping-gene-fusions
#2
Nimesh R Patel, John S A Chrisinger, Elizabeth G Demicco, Stephen F Sarabia, Jacquelyn Reuther, Erica Kumar, Andre M Oliveira, Steven D Billings, Judith V M G Bovée, Angshumoy Roy, Alexander J Lazar, Dolores H Lopez-Terrada, Wei-Lien Wang
Nodular fasciitis is a self-limited myofibroblastic lesion that can be misdiagnosed as a sarcoma as a result of its rapid growth, cellularity, and sometimes prominent mitotic activity. A recurrent translocation t(17;22) has been identified in nodular fasciitis, fusing the coding region of USP6 to the promoter region of MYH9, and resulting in increased USP6 expression. A subset of cases show USP6 rearrangement without the typical fusion variants by RT-PCR, or any MYH9 rearrangement by FISH. We sought to further characterize such tumors using molecular diagnostic assays...
July 28, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28751104/myofibroblastic-fibroblastic-and-myoid-lesions-of-the-breast
#3
REVIEW
Gregor Krings, Patrick McIntire, Sandra J Shin
Myofibroblastic, fibroblastic and/or myoid lesions are rare in the breast but comprise the majority of mammary mesenchymal spindle cell lesions. Whereas most have similar features to their counterparts at extramammary sites, pseudoangiomatous stromal hyperplasia is considered a breast-specific myofibroblastic proliferation on the same spectrum as myofibroblastoma. Other lesions with myofibroblastic/fibroblastic differentiation include fibromatosis and nodular fasciitis, as well as more aggressive tumors such as the rarely reported myofibrosarcoma, inflammatory myofibroblastic tumor and fibrosarcoma...
September 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/28693291/diagnostic-clue-of-nodular-fasciitis-mimicking-metastasis-in-papillary-thyroid-cancer-mismatching-findings-on-18-f-fdg-pet-ct-and-123-i-whole-body-scan-a-case-report
#4
Minjung Seo, Misung Kim, Eun Sook Kim, Hongbo Sim, Sungmin Jun, Seol Hoon Park
This study reports a case of nodular fasciitis incidentally detected in a patient with papillary thyroid cancer. A 47-year-old woman underwent a total thyroidectomy and radioactive iodine therapy for papillary thyroid cancer. On a follow-up fluorodeoxyglucose ((18)F-FDG) PET/computed tomography (CT) scan after 12 months, a focal (18)F-FDG-avid lesion was incidentally detected in the paraspinal muscle. It was well-enhanced on CT and magnetic resonance imaging, indicating metastasis. However, the lesion was not iodine avid on the (123)I whole body scan, which favored benign etiology over metastasis from thyroid cancer...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28546724/nodular-fasciitis-in-the-tongue-a-mimicker-of-malignancy-case-report-and-review-of-literature
#5
Jency Joy Chemmanam
Tongue cancer surgery involves wide excision of tumors with negative margins. It can cause significant morbidity if adequate function is not restored with the use of grafts or flaps if the defect is large. Nodular fasciitis is an uncommon entity in the tongue and a mimicker of malignancy. Preoperative diagnosis avoids mutilating radical surgery. The lesion is benign and the recurrence potential is very low with marginal excision.
June 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28544823/fine-needle-aspiration-cytology-findings-of-myxoinflammatory-fibroblastic-sarcoma-a-case-report
#6
Satoru Ozaki, Satomi Kasashima, Atsuhiro Kawashima, Akishi Ooi
Myxoinflammatory fibroblastic sarcoma (MIFS) is rare low-grade soft-tissue tumor that occurs in extremities. Clinically it is difficult to differentiate from benign lesions, such as nodular fasciitis, and malignant tumors, such as liposarcoma. We report a case of MIFS in the forearm of a 34-year-old man. The resected tumor measured 5.3 × 2.7 × 2.5 cm(3) , had a lobular structure with indistinct boundary, and consisted of a large amount of translucent and yellow mucous-like substrate. Cytological examination of a preoperative puncture aspiration specimen showed histiocyte- and fibroblast-like tumor cells in a mucous-like matrix together with scattered lipoblast- and ganglion-like cells...
May 24, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28477272/hif-1%C3%AE-mdm2-cdk4-and-p16-expression-in-ischemic-fasciitis-focusing-on-its-ischemic-condition
#7
Yuichi Yamada, Izumi Kinoshita, Kenichi Kohashi, Hidetaka Yamamoto, Yuki Kuma, Takamichi Ito, Kenji Koda, Atsushi Kisanuki, Manabu Kurosawa, Michiko Yoshimura, Masutaka Furue, Yoshinao Oda
Ischemic fasciitis is a benign myofibroblastic lesion, occurring in the sacral region or proximal thigh of elderly or bedridden individuals. The pathogenesis of ischemic fasciitis is thought to be based on ischemic condition; however, it has never been demonstrated. In this study, we examined the expression of ischemia-associated proteins in ischemic fasciitis by immunohistochemical and genetic methods. Specifically, this study aimed to reveal the expression of HIF-1α, MDM2, CDK4, p16, and gene amplification of MDM2 gene...
July 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28476380/claudin-6-expression-is-useful-to-distinguish-myxofibrosarcomas-from-other-myxoid-soft-tissue-tumors
#8
Hirofumi Bekki, Hidetaka Yamamoto, Katsumi Takizawa, Takeshi Iwasaki, Hiroshi Otsuka, Yuichi Yamada, Kenichi Kohashi, Katsumi Harimaya, Yukihide Iwamoto, Yoshinao Oda
Myxofibrosarcoma (MFS) is characterized by abundant myxoid stroma, a wide spectrum of cytological atypia, and frequent local recurrence. Some soft tissue tumors with myxoid stroma can histologically mimic MFS, but have different biological behaviors. Here we sought to identify a useful diagnostic marker for MFS. After our analysis of the gene expression dataset from the Gene Expression Omnibus database, we focused on claudin 6 (CLDN 6). The status of CLDN 6 was assessed by immunohistochemistry in 61 samples of MFS and other (benign) myxoid soft tissue tumors (28 myxoma samples, 12 nodular fasciitis samples), 18 low-grade fibromyxoid sarcoma, 30 myxoid liposarcoma, 29 extraskeletal myxoid chondrosarcoma and 27 dedifferentiated liposarcoma with myxoid feature samples...
June 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28431711/nodular-fasciitis-of-the-posterior-chest-wall-with-bone%C3%A2-invasion-mimicking-a-malignant-neoplasm
#9
Nicholas J Olson, David J Finley, Michael J Tsapakos, Sandra L Wong, Konstantinos Linos
Nodular fasciitis is a self-limiting benign fibroblastic/myofibroblastic proliferation, which typically presents as a rapidly growing mass resembling an aggressive lesion clinically. It can also mimic a sarcoma histologically, hence the frequent characterization as "pseudosarcoma." We describe a case of a 53-year-old man who presented with a posterior chest wall mass that on imaging showed erosion into the adjacent ribs. After resection, the diagnosis of nodular fasciitis was rendered. Bone erosion by nodular fasciitis is extremely rare and can resemble a malignant neoplasm radiologically...
May 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28426899/ultrasonographic-features-of-intravascular-fasciitis-case-report-and-review-of-the-literature
#10
K Takahashi, T Yanagi, K Imafuku, S Kitamura, Y Inamura-Takashima, Y Yamaguchi, H Hata, H Shimizu
Intravascular fasciitis (IF), a variant of nodular fasciitis (NF), is a reactive intravascular proliferation of myofibroblasts. IF is an indolent subcutaneous or intramuscular nodule that is most commonly found on the extremities, head and neck.(1, 2) This article is protected by copyright. All rights reserved.
April 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28288478/benign-temporomandibular-joint-lesions-presenting-as-masses-in-the-external-auditory-canal
#11
Ryan A Williams, Robert K Jackler, C Eduardo Corrales
OBJECTIVE: Describe benign lesions arising from the temporomandibular joint (TMJ) that presented as masses in the external auditory canal (EAC). STUDY DESIGN: Retrospective case series of two academic medical centers. PATIENTS: Six patients with lesions emanating from the TMJ that presented as EAC masses. Lesions included pigmented villonodular synovitis (PVNS), nodular fasciitis, foramen of Huschke herniation with salivary fistula, fibroepithelial polyp, superficial angiomyxoma, and giant cell tumor (GCT)...
April 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28262308/periosteal-fasciitis-in-a-7-year-old-girl-a-diagnostic-dilemma
#12
M Lääveri, K Heikinheimo, D Baumhoer, P J Slootweg, R-P Happonen
Periosteal fasciitis, considered a subtype of nodular fasciitis, is a rare benign soft tissue mass often misdiagnosed as a malignant lesion due to its fast and infiltrative growth pattern and histological features. Nodular fasciitis is usually found in the upper extremities in adults and in the head and neck region in children. Incorrect diagnosis may lead to overtreatment, potentially causing disturbed orofacial development in growing children. A rapidly growing asymptomatic mass, initially suspected to be a malignant bone tumour, was found in the left angle area of the mandible in a healthy 7-year-old girl...
July 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28253912/nodular-fasciitis-of-the-breast-clinically-resembling-breast-cancer-in-an-elderly-woman-a-case-report
#13
Satoshi Hayashi, Shunsuke Yasuda, Nana Takahashi, Satoshi Okazaki, Kei Ishibashi, Masahiro Kitada, Naoyuki Miyokawa
BACKGROUND: Nodular fasciitis is a benign reactive proliferative lesion of fibroblast cells, which can occur throughout the body. However, it has rarely been reported in the breast of an elderly woman. CASE PRESENTATION: Our patient was an 88-year-old Asian woman who had noticed a mass in her right breast for 1 month before presentation to our hospital. The mass was elastic-hard and 20 mm in size. No qualitative diagnosis was made by core needle biopsy. Because of potentially malignant findings on mammography and ultrasonography, she underwent an excisional biopsy...
March 3, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28108880/unusual-signal-patterns-of-break-apart-fish-probes-used-in-the-diagnosis-of-soft-tissue-sarcomas
#14
Gergő Papp, Dóra Mihály, Zoltán Sápi
Break-apart FISH probes are the most popular and reliable type of FISH probes used to confirm certain pathological diagnoses. The interpretation is usually easy, however, in some instances it is not so unequivocal. Our aim was to reveal and elucidate the problems occurring in the process of evaluation of the break-apart probe results. Altogether 301 soft tissue sarcomas with confirmed molecular tests using break-apart probes were assessed to reveal the frequency and type of unusual signal pattern. Among 89 synovial sarcoma (SS18) 11%, 12 alveolar rhabdomyosarcoma (FOXO1) 50%, 53 myxoid liposarcoma (DDIT3) 7...
January 20, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28065541/nodular-fasciitis-sonographic-pathologic-correlation
#15
Ho-Hsian Yen, Hong-Jen Chiou, Yi-Hong Chou, Chih-Hsueh Chen, Wan-Yuo Guo
We evaluated nodular fasciitis (NF) in 19 patients, focusing on the correlation between its sonographic and histopathologic features. Sonograms were retrospectively reviewed, and the location, shape, margin, echogenicity, echogenic rim, peripheral hyper-echoic nodules, posterior enhancement and vascularity of the lesions were recorded. In the histopathologic analysis, three patterns-infiltrating, pushing border and well circumscribed-were identified, and culture-like tissue centers were classified according to the distribution of focal keloid-like collagen bundles: uneven or even...
April 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28042407/nodular-fasciitis-of-the-neck-causing-emergency-a-case-report
#16
Serkan Yaşar Çelik, Yelda Dere, Özgür İlhan Çelik, Serhan Derin, Murat Şahan, Özcan Dere
Nodular fasciitis is a benign, reactive, tumor-like lesion composed of fibroblasts and myofibroblasts. It typically occurs in the extremities and the trunk. Head and neck localization is 13-20%. As it grows rapidly, clinicians frequently misdiagnose it as an aggressive or a malignant lesion. Some lesions show moderate cellularity, mild cellular atypia, and mitosis histologically causing pathologists to over-diagnose the lesion as a malignant tumor. It is important to diagnose nodular fasciitis correctly to avoid unnecessary additional surgery and treatment...
January 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/28018683/nodular-fasciitis-complicating-a-staged-surgical-excision-of-dermatofibrosarcoma-protuberans
#17
C Helen Malone, Brandon Goodwin, Richard F Wagner, Vicente Resto, Brent Kelly
Dermatofibrosarcoma protuberans (DFSP) is an unusual spindle cell tumor with a high rate of local recurrence with traditional excision. Fortunately, Mohs micrographic surgery yields excellent cure rates for this neoplasm due to contiguous tumor spread and meticulous tumor mapping and margin analysis. We present the unique case of a patient treated with a modified Mohs technique with an analysis of the final margin with permanent sections, who developed a spindle cell neoplasm in the margins of her second stage excision consistent with nodular fasciitis...
2016: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/28009608/fosb-is-a-useful-diagnostic-marker-for-pseudomyogenic-hemangioendothelioma
#18
Yin P Hung, Christopher D M Fletcher, Jason L Hornick
Pseudomyogenic (epithelioid sarcoma-like) hemangioendothelioma is a distinctive vascular neoplasm of intermediate biological potential with a predilection for young adults and frequent multifocal presentation. Pseudomyogenic hemangioendothelioma is characterized by loose fascicles of plump spindled and epithelioid cells with abundant eosinophilic cytoplasm and coexpression of keratins and endothelial markers. Recently, a SERPINE1-FOSB fusion has been identified as a consistent genetic alteration in pseudomyogenic hemangioendothelioma...
May 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27957702/imaging-of-plantar-fascia-disorders-findings-on-plain-radiography-ultrasound-and-magnetic-resonance-imaging
#19
REVIEW
Ferdinando Draghi, Salvatore Gitto, Chandra Bortolotto, Anna Guja Draghi, Gioia Ori Belometti
Plantar fascia (PF) disorders commonly cause heel pain and disability in the general population. Imaging is often required to confirm diagnosis. This review article aims to provide simple and systematic guidelines for imaging assessment of PF disease, focussing on key findings detectable on plain radiography, ultrasound and magnetic resonance imaging (MRI). Sonographic characteristics of plantar fasciitis include PF thickening, loss of fibrillar structure, perifascial collections, calcifications and hyperaemia on Doppler imaging...
February 2017: Insights Into Imaging
https://www.readbyqxmd.com/read/27772869/a-spontaneously-resolving-breast-lesion-cytological-findings-of-nodular-fasciitis-of-the-breast
#20
A R Kang, J Kumar, A Bourke, F Frost, A A Thomas
No abstract text is available yet for this article.
February 2016: Pathology
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