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nodular fasciitis

A R Kang, J Kumar, A Bourke, F Frost, A A Thomas
No abstract text is available yet for this article.
February 2016: Pathology
Ajithakumari Kumaran, Sathi Puthenparambath
A 10-year-old boy presented with a swelling of the left mid upper arm of 1 month duration. Fine-needle aspiration (FNA) diagnosis of pseudosarcomatous lesion, suggestive of nodular fasciitis, was made and advised radiological examination. Magnetic resonance imaging (MRI) diagnosis was benign fibroblastic tumor. Excisional biopsy was done and histopathology confirmed the diagnosis of nodular fasciitis. As of now, the child is absolutely alright after 1 year.
July 2016: Journal of Cytology
Marián Švajdler, Michael Michal, Pavol Dubinský, Peter Švajdler, Ondrej Ondič, Michal Michal
We describe a case of an unusual endometrial endometrioid carcinoma occurring in a 67-year-old woman. The tumor involved uterine corpus as well as lower uterine segment and presented as polypoid tumor protruding through the cervical orifice. Microscopically, the tumor was characterized by broad zones of cytologically bland fibromyxoid stroma resembling nodular fasciitis, showing vaguely nodular architecture. Neoplastic glands were characterized by interconnected elongated slit-like and large cystic profiles, mostly lined by flattened epithelium with variable squamous differentiation, whereas typical columnar endometrioid cells were only focally present...
November 2016: Advances in Anatomic Pathology
Panagiotis Paliogiannis, Antonio Cossu, Giuseppe Palmieri, Fabrizio Scognamillo, Carlo Pala, Rita Nonnis, Giovanni Sotgiu, Alessandro Fois, Grazia Palomba, Federico Attene
BACKGROUND: This article describes the demographic, clinical, pathological and prognostic features of breast nodular fasciitis through a comprehensive review of the cases reported in modern literature. MATERIAL AND METHODS: English-language articles published from January 1970 to October 2015 and related to breast nodular fasciitis were non-systematically retrieved using the PubMed database. Titles, abstracts and references were evaluated in order to include the most relevant studies...
August 2016: Breast Care
Caterina Rebecchini, Antoine Nobile, Simonetta Piana, Rossella Sarro, Bettina Bisig, Sykiotis P Gerasimos, Chiara Saglietti, Maurice Matter, Laura Marino, Massimo Bongiovanni
Various histological variants of papillary thyroid carcinoma have been reported, some with clinical implications, some with peculiar, sometimes misleading morphologies. One of these rare and poorly characterized variants is papillary thyroid carcinoma with nodular fasciitis-like stroma, of which fewer than 30 cases have been documented, mostly as isolated reports. It is a dual tumor comprising a malignant epithelial proliferation that harbors typical features of conventional papillary thyroid carcinoma, admixed with a prominent mesenchymal proliferation resembling nodular fasciitis or fibromatosis...
October 7, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Erica Kumar, Nimesh R Patel, Elizabeth G Demicco, Judith V M G Bovee, Andre M Olivera, Dolores H Lopez-Terrada, Steven D Billings, Alexander J Lazar, Wei-Lien Wang
Nodular fasciitis is a benign self-limited myofibroblastic neoplasm, which usually involves the upper extremities and trunk of young patients. These tumors have been shown to harbor a translocation involving the MYH9 and USP6 genes, leading to overexpression of the latter. We report seven cases of nodular fasciitis with cutaneous presentations. All cases involved the dermis, with six involving the superficial subcutis, and one auricular tumor extending into cartilage. All cases showed USP6 rearrangement by fluorescence in situ hybridization; in two of three cases, the characteristic MYH9-USP6 fusion was shown by RT-PCR...
December 2016: Journal of Cutaneous Pathology
Derek B Allison, Paul E Wakely, Momin T Siddiqui, Syed Z Ali
BACKGROUND: Nodular fasciitis (NF) is a benign, self-limited, fibroblastic/myofibroblastic proliferation that is diagnostically challenging, often mimicking a malignant process due to its rapid growth clinically and its high cellularity, mitotic activity, and variable/nonspecific cytomorphologic findings. Herein, the authors report what to their knowledge is the largest and first multi-institutional study of the cytomorphologic characteristics of NF by fine-needle aspiration (FNA). METHODS: The pathology archives at The Johns Hopkins Hospital, The Ohio State University Wexner Medical Center, and Emory University Hospital were searched for soft tissue FNA cytology specimens of masses confirmed to be NF...
August 15, 2016: Cancer Cytopathology
Joost T P Kortlever, Stein J Janssen, Jeroen Molleman, Michiel G J S Hageman, David Ring
BACKGROUND: Nonspecific symptoms are common in all areas of medicine. Patients and caregivers can be frustrated when an illness cannot be reduced to a discrete pathophysiological process that corresponds with the symptoms. We therefore asked the following questions: 1) Which demographic factors and psychological comorbidities are associated with change from an initial diagnosis of nonspecific arm pain to eventual identification of discrete pathophysiology that corresponds with symptoms? 2) What is the percentage of patients eventually diagnosed with discrete pathophysiology, what are those pathologies, and do they account for the symptoms? METHODS: We evaluated 634 patients with an isolated diagnosis of nonspecific upper extremity pain to see if discrete pathophysiology was diagnosed on subsequent visits to the same hand surgeon, a different hand surgeon, or any physician within our health system for the same pain...
June 2016: Archives of Bone and Joint Surgery
Anandhi Amaranathan, Vishnu Prasad Nelamangala Ramakrishnaiah, Susan Rajan, Rajesh Nachiappa Ganesh
Nodular Fasciitis (NF) is described as a benign reactive proliferation of myofibroblasts that occurs predominantly in the subcutaneous location. Most commonly presents as rapidly growing swelling in the young adults, with usual size of less than 4cm and located commonly in the extremities. We hereby report a case of giant nodular fasciitis of 10cm diameter which presented in an unusual location (gluteal region) and rare plane of origin (intramuscular) with unusual symptom of sciatic nerve involvement. Because of the size, location and neural involvement a clinical diagnosis of soft tissue sarcoma was made...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
Martin Henninger, Tobias Maurer, Charlotte Hacker, Matthias Eiber
The recently introduced PSMA PET has developed as a powerful imaging tool for staging of prostate cancer. This case showed an intense uptake of Ga-PSMA in a soft-tissue mass of the rectus femoris muscle. Histopathology revealed the diagnosis of fasciitis nodularis. Therefore, it advises caution particularly in patients with solitary and atypical located lesions as they might not be indicative for metastatic prostate cancer, but eventually be caused by different conditions.
October 2016: Clinical Nuclear Medicine
Kohei Kanaya, Kousuke Iba, Toshihiko Yamashita, Takuro Wada, Tadashi Hasegawa
We present the case of an 11-year-old boy with intraneural nodular fasciitis of the median nerve at the distal part of the carpal tunnel. Complete excision of the involved median nerve and cable grafting using 4 fascicular segments of the sural nerve was performed for persistent pain and numbness after initial resection of the tumor in piecemeal fashion. Pain and numbness were completely resolved and there was no evidence of recurrence 24 months after the final surgery.
September 2016: Journal of Hand Surgery
David John Massop, Paul Adam Frederick, He J Li, Amy Lin
PURPOSE: To report a case of epibulbar nodular fasciitis in a 32-year-old female and provide context by reviewing the current literature. RESULTS: Using excisional biopsy, the patient was successfully diagnosed and treated for epibulbar nodular fasciitis. Upon follow-up, there has been no recurrence, consistent with the typical course for nodular fasciitis. CONCLUSIONS: Epibulbar nodular fasciitis is a rare process that can be successfully treated by surgical resection...
January 2016: Case Reports in Ophthalmology
Laura Quick, Robert Young, Ian C Henrich, Xiaoke Wang, Yan W Asmann, Andre M Oliveira, Margaret M Chou
Bone and soft tissue tumors (BSTT) are relatively poorly understood, hampering the development of effective therapies. Here we report a role for the ubiquitin-specific protease 6 (USP6)/TRE17 oncogene, which is overexpressed upon chromosome translocation in various human tumors, including aneurysmal bone cyst (ABC), and the related benign lesion nodular fasciitis. Ectopic expression of USP6 is known to drive formation of tumors, which recapitulate key features of ABC and nodular fasciitis; however, the identity of USP6's relevant substrates has been obscure...
September 15, 2016: Cancer Research
Arvind Krishnamurthy, Suhail Deen, Urmila Majhi
Nodular fasciitis is a benign proliferative spindle-cell lesion that presents as a rapidly growing mass arising from the subcutaneous fascia, leading it to be erroneously diagnosed as a sarcoma. These lesions commonly present in individuals in their third to fifth decades of life with no definite gender predilection. They are frequently located on the extremities and the trunk and infrequently in the head and neck region. Lesions in the orofacial region are uncommon. We describe an interesting case of orofacial nodular fasciitis in a 21-year-old boy that essentially summarises the clinical features and management of this pseudosarcomatous reactive proliferative lesion...
July 2016: Journal of Maxillofacial and Oral Surgery
Damera Srikanth, Vaishnavi Devi, Naveen Polishetty, Dal Singh
Fibrous histiocytoma is a benign tumor of mesenchymal origin. The tumor frequently appears in sun exposed areas on skin and orbital tissues. The subcutaneous appearance of this tumor in deep soft tissues is rare. We present here the eighth reported case of subcutaneous benign fibrohistiocytoma in a 27 year old male patient. Histopathology of the tumor comprises fibroblastic and histiocytic cells which mimic dermatofibroma, xanthomas and nodular fasciitis. Special stains like vimentin can only differentiate these tumors...
July 2016: Journal of Maxillofacial and Oral Surgery
Jihyun Ahn, Sunyoung Kim, Youngsil Park
Nodular fasciitis is a pseudosarcomatous reactive process composed of fibroblasts and myofibroblasts, and it is most common in the upper extremities. Nodular fasciitis of the external auditory canal is rare. To the best of our knowledge, less than 20 cases have been reported to date. We present a case of nodular fasciitis arising in the cartilaginous part of the external auditory canal. A 19-year-old man complained of an auricular mass with pruritus. Computed tomography showed a 1.7 cm sized soft tissue mass in the right external auditory canal, and total excision was performed...
September 2016: Journal of Pathology and Translational Medicine
Christina Shin, Irene Low, Daniel Ng, Paul Oei, Carina Miles, Pennie Symmans
AIMS: Nodular fasciitis is known to be a benign mimic of sarcoma, both clinically and histologically. Accurate diagnosis, particularly on small biopsies, remains a challenge, as the morphology can be varied and the immunophenotype is essentially non-specific. Recently, rearrangement of the ubiquitin-specific protease 6 (USP6) gene has been reported as a recurrent and specific finding in nodular fasciitis. The aim of this this study was to evaluate the diagnostic utility of USP6 fluorescence in-situ hybridization (FISH) analysis in a subset of spindle-cell proliferations in which nodular fasciitis enters into the differential diagnosis...
June 6, 2016: Histopathology
Qiao Zhou, Daniel Young, Harlan Vingan
20 year old female with no prior medical history presents with diffuse cervical lymphadenopathy. CT and subsequent positron emission tomography-computed tomography (PET/CT) demonstrated diffuse lymphatomous involvement of multiple lymph nodes in the neck, mediastinum, and retroperitoneum. The patient underwent ABVD therapy which resulted in the lymphoma being in remission for 2 years. The patient had a repeat PET/CT done after 2 years due to complaints of recurrent lymphadenopathy. The PET/CT revealed a new hypermetabolic focus by the right femur...
June 2016: Radiology case reports
Primali Rukmal Jayasooriya, Lindumini Nayanahari Madawalagamage, Balapuwaduge Ranjit Rigorbert Nihal Mendis, Tommaso Lombardi
In the head and neck region, synovial sarcomas (SS) are rare tumours. We describe the diagnostic approach to SS based on two cases which developed in a 26-year-old male in the face and in a 53-year-old female on the alveolar mucosa of the upper jaw. The demographic profile of the patients was compatible with the literature. Histopathologically, both tumours presented as unencapsulated spindle cell tumours arranged into short fascicles. Although the chromosomal translocation of t(X;18)(p11.2;q11.2), transducin-like enhancer of split 1 (TLE-1) and SMARCB1 antibodies derived from gene expression studies are considered as the most sensitive makers to diagnose SS, these facilities were not available...
January 2016: Dermatopathology (Basel, Switzerland)
Babita Madan, Matthew P Walker, Robert Young, Laura Quick, Kelly A Orgel, Meagan Ryan, Priti Gupta, Ian C Henrich, Marc Ferrer, Shane Marine, Brian S Roberts, William T Arthur, Jason D Berndt, Andre M Oliveira, Randall T Moon, David M Virshup, Margaret M Chou, Michael B Major
The Wnt signaling pathways play pivotal roles in carcinogenesis. Modulation of the cell-surface abundance of Wnt receptors is emerging as an important mechanism for regulating sensitivity to Wnt ligands. Endocytosis and degradation of the Wnt receptors Frizzled (Fzd) and lipoprotein-related protein 6 (LRP6) are regulated by the E3 ubiquitin ligases zinc and ring finger 3 (ZNRF3) and ring finger protein 43 (RNF43), which are disrupted in cancer. In a genome-wide small interfering RNA screen, we identified the deubiquitylase ubiquitin-specific protease 6 (USP6) as a potent activator of Wnt signaling...
May 24, 2016: Proceedings of the National Academy of Sciences of the United States of America
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