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nodular fasciitis

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https://www.readbyqxmd.com/read/28108880/unusual-signal-patterns-of-break-apart-fish-probes-used-in-the-diagnosis-of-soft-tissue-sarcomas
#1
Gergő Papp, Dóra Mihály, Zoltán Sápi
Break-apart FISH probes are the most popular and reliable type of FISH probes used to confirm certain pathological diagnoses. The interpretation is usually easy, however, in some instances it is not so unequivocal. Our aim was to reveal and elucidate the problems occurring in the process of evaluation of the break-apart probe results. Altogether 301 soft tissue sarcomas with confirmed molecular tests using break-apart probes were assessed to reveal the frequency and type of unusual signal pattern. Among 89 synovial sarcoma (SS18) 11%, 12 alveolar rhabdomyosarcoma (FOXO1) 50%, 53 myxoid liposarcoma (DDIT3) 7...
January 20, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28065541/nodular-fasciitis-sonographic-pathologic-correlation
#2
Ho-Hsian Yen, Hong-Jen Chiou, Yi-Hong Chou, Chih-Hsueh Chen, Wan-Yuo Guo
We evaluated nodular fasciitis (NF) in 19 patients, focusing on the correlation between its sonographic and histopathologic features. Sonograms were retrospectively reviewed, and the location, shape, margin, echogenicity, echogenic rim, peripheral hyper-echoic nodules, posterior enhancement and vascularity of the lesions were recorded. In the histopathologic analysis, three patterns-infiltrating, pushing border and well circumscribed-were identified, and culture-like tissue centers were classified according to the distribution of focal keloid-like collagen bundles: uneven or even...
January 5, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28042407/nodular-fasciitis-of-the-neck-causing-emergency-a-case-report
#3
Serkan Yaşar Çelik, Yelda Dere, Özgür İlhan Çelik, Serhan Derin, Murat Şahan, Özcan Dere
Nodular fasciitis is a benign, reactive, tumor-like lesion composed of fibroblasts and myofibroblasts. It typically occurs in the extremities and the trunk. Head and neck localization is 13-20%. As it grows rapidly, clinicians frequently misdiagnose it as an aggressive or a malignant lesion. Some lesions show moderate cellularity, mild cellular atypia, and mitosis histologically causing pathologists to over-diagnose the lesion as a malignant tumor. It is important to diagnose nodular fasciitis correctly to avoid unnecessary additional surgery and treatment...
January 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/28018683/nodular-fasciitis-complicating-a-staged-surgical-excision-of-dermatofibrosarcoma-protuberans
#4
C Helen Malone, Brandon Goodwin, Richard F Wagner, Vicente Resto, Brent Kelly
Dermatofibrosarcoma protuberans (DFSP) is an unusual spindle cell tumor with a high rate of local recurrence with traditional excision. Fortunately, Mohs micrographic surgery yields excellent cure rates for this neoplasm due to contiguous tumor spread and meticulous tumor mapping and margin analysis. We present the unique case of a patient treated with a modified Mohs technique with an analysis of the final margin with permanent sections, who developed a spindle cell neoplasm in the margins of her second stage excision consistent with nodular fasciitis...
2016: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/28009608/fosb-is-a-useful-diagnostic-marker-for-pseudomyogenic-hemangioendothelioma
#5
Yin P Hung, Christopher D M Fletcher, Jason L Hornick
Pseudomyogenic (epithelioid sarcoma-like) hemangioendothelioma is a distinctive vascular neoplasm of intermediate biological potential with a predilection for young adults and frequent multifocal presentation. Pseudomyogenic hemangioendothelioma is characterized by loose fascicles of plump spindled and epithelioid cells with abundant eosinophilic cytoplasm and coexpression of keratins and endothelial markers. Recently, a SERPINE1-FOSB fusion has been identified as a consistent genetic alteration in pseudomyogenic hemangioendothelioma...
December 22, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27957702/imaging-of-plantar-fascia-disorders-findings-on-plain-radiography-ultrasound-and-magnetic-resonance-imaging
#6
REVIEW
Ferdinando Draghi, Salvatore Gitto, Chandra Bortolotto, Anna Guja Draghi, Gioia Ori Belometti
Plantar fascia (PF) disorders commonly cause heel pain and disability in the general population. Imaging is often required to confirm diagnosis. This review article aims to provide simple and systematic guidelines for imaging assessment of PF disease, focussing on key findings detectable on plain radiography, ultrasound and magnetic resonance imaging (MRI). Sonographic characteristics of plantar fasciitis include PF thickening, loss of fibrillar structure, perifascial collections, calcifications and hyperaemia on Doppler imaging...
February 2017: Insights Into Imaging
https://www.readbyqxmd.com/read/27772869/a-spontaneously-resolving-breast-lesion-cytological-findings-of-nodular-fasciitis-of-the-breast
#7
A R Kang, J Kumar, A Bourke, F Frost, A A Thomas
No abstract text is available yet for this article.
February 2016: Pathology
https://www.readbyqxmd.com/read/27756994/fine-needle-aspiration-diagnosis-of-nodular-fasciitis-a-case-report
#8
Ajithakumari Kumaran, Sathi Puthenparambath
A 10-year-old boy presented with a swelling of the left mid upper arm of 1 month duration. Fine-needle aspiration (FNA) diagnosis of pseudosarcomatous lesion, suggestive of nodular fasciitis, was made and advised radiological examination. Magnetic resonance imaging (MRI) diagnosis was benign fibroblastic tumor. Excisional biopsy was done and histopathology confirmed the diagnosis of nodular fasciitis. As of now, the child is absolutely alright after 1 year.
July 2016: Journal of Cytology
https://www.readbyqxmd.com/read/27740962/endometrial-endometrioid-carcinoma-with-large-cystic-growth-configuration-and-deceptive-pattern-of-invasion-associated-with-abundant-nodular-fasciitis-like-stroma-a-unique-hitherto-unreported-histology-in-endometrioid-carcinoma
#9
Marián Švajdler, Michael Michal, Pavol Dubinský, Peter Švajdler, Ondrej Ondič, Michal Michal
We describe a case of an unusual endometrial endometrioid carcinoma occurring in a 67-year-old woman. The tumor involved uterine corpus as well as lower uterine segment and presented as polypoid tumor protruding through the cervical orifice. Microscopically, the tumor was characterized by broad zones of cytologically bland fibromyxoid stroma resembling nodular fasciitis, showing vaguely nodular architecture. Neoplastic glands were characterized by interconnected elongated slit-like and large cystic profiles, mostly lined by flattened epithelium with variable squamous differentiation, whereas typical columnar endometrioid cells were only focally present...
November 2016: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/27721715/breast-nodular-fasciitis-a-comprehensive-review
#10
REVIEW
Panagiotis Paliogiannis, Antonio Cossu, Giuseppe Palmieri, Fabrizio Scognamillo, Carlo Pala, Rita Nonnis, Giovanni Sotgiu, Alessandro Fois, Grazia Palomba, Federico Attene
BACKGROUND: This article describes the demographic, clinical, pathological and prognostic features of breast nodular fasciitis through a comprehensive review of the cases reported in modern literature. MATERIAL AND METHODS: English-language articles published from January 1970 to October 2015 and related to breast nodular fasciitis were non-systematically retrieved using the PubMed database. Titles, abstracts and references were evaluated in order to include the most relevant studies...
August 2016: Breast Care
https://www.readbyqxmd.com/read/27713418/papillary-thyroid-carcinoma-with-nodular-fasciitis-like-stroma-and-%C3%AE-catenin-mutations-should-be-renamed-papillary-thyroid-carcinoma-with-desmoid-type-fibromatosis
#11
Caterina Rebecchini, Antoine Nobile, Simonetta Piana, Rossella Sarro, Bettina Bisig, Sykiotis P Gerasimos, Chiara Saglietti, Maurice Matter, Laura Marino, Massimo Bongiovanni
Various histological variants of papillary thyroid carcinoma have been reported, some with clinical implications, some with peculiar, sometimes misleading morphologies. One of these rare and poorly characterized variants is papillary thyroid carcinoma with nodular fasciitis-like stroma, of which fewer than 30 cases have been documented, mostly as isolated reports. It is a dual tumor comprising a malignant epithelial proliferation that harbors typical features of conventional papillary thyroid carcinoma, admixed with a prominent mesenchymal proliferation resembling nodular fasciitis or fibromatosis...
February 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27686647/cutaneous-nodular-fasciitis-with-genetic-analysis-a-case-series
#12
Erica Kumar, Nimesh R Patel, Elizabeth G Demicco, Judith V M G Bovee, Andre M Olivera, Dolores H Lopez-Terrada, Steven D Billings, Alexander J Lazar, Wei-Lien Wang
Nodular fasciitis is a benign self-limited myofibroblastic neoplasm, which usually involves the upper extremities and trunk of young patients. These tumors have been shown to harbor a translocation involving the MYH9 and USP6 genes, leading to overexpression of the latter. We report seven cases of nodular fasciitis with cutaneous presentations. All cases involved the dermis, with six involving the superficial subcutis, and one auricular tumor extending into cartilage. All cases showed USP6 rearrangement by fluorescence in situ hybridization; in two of three cases, the characteristic MYH9-USP6 fusion was shown by RT-PCR...
December 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27525591/nodular-fasciitis-a-frequent-diagnostic-pitfall-on-fine-needle-aspiration
#13
Derek B Allison, Paul E Wakely, Momin T Siddiqui, Syed Z Ali
BACKGROUND: Nodular fasciitis (NF) is a benign, self-limited, fibroblastic/myofibroblastic proliferation that is diagnostically challenging, often mimicking a malignant process due to its rapid growth clinically and its high cellularity, mitotic activity, and variable/nonspecific cytomorphologic findings. Herein, the authors report what to their knowledge is the largest and first multi-institutional study of the cytomorphologic characteristics of NF by fine-needle aspiration (FNA). METHODS: The pathology archives at The Johns Hopkins Hospital, The Ohio State University Wexner Medical Center, and Emory University Hospital were searched for soft tissue FNA cytology specimens of masses confirmed to be NF...
August 15, 2016: Cancer Cytopathology
https://www.readbyqxmd.com/read/27517064/discrete-pathophysiology-is-uncommon-in-patients-with-nonspecific-arm-pain
#14
Joost T P Kortlever, Stein J Janssen, Jeroen Molleman, Michiel G J S Hageman, David Ring
BACKGROUND: Nonspecific symptoms are common in all areas of medicine. Patients and caregivers can be frustrated when an illness cannot be reduced to a discrete pathophysiological process that corresponds with the symptoms. We therefore asked the following questions: 1) Which demographic factors and psychological comorbidities are associated with change from an initial diagnosis of nonspecific arm pain to eventual identification of discrete pathophysiology that corresponds with symptoms? 2) What is the percentage of patients eventually diagnosed with discrete pathophysiology, what are those pathologies, and do they account for the symptoms? METHODS: We evaluated 634 patients with an isolated diagnosis of nonspecific upper extremity pain to see if discrete pathophysiology was diagnosed on subsequent visits to the same hand surgeon, a different hand surgeon, or any physician within our health system for the same pain...
June 2016: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/27504350/giant-intramuscular-nodular-fasciitis-masquerading-as-soft-tissue-sarcoma-with-neural-involvement-a-case-report
#15
Anandhi Amaranathan, Vishnu Prasad Nelamangala Ramakrishnaiah, Susan Rajan, Rajesh Nachiappa Ganesh
Nodular Fasciitis (NF) is described as a benign reactive proliferation of myofibroblasts that occurs predominantly in the subcutaneous location. Most commonly presents as rapidly growing swelling in the young adults, with usual size of less than 4cm and located commonly in the extremities. We hereby report a case of giant nodular fasciitis of 10cm diameter which presented in an unusual location (gluteal region) and rare plane of origin (intramuscular) with unusual symptom of sciatic nerve involvement. Because of the size, location and neural involvement a clinical diagnosis of soft tissue sarcoma was made...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27488427/68ga-psma-pet-mr-showing-intense-psma-uptake-in-nodular-fasciitis-mimicking-prostate-cancer-metastasis
#16
Martin Henninger, Tobias Maurer, Charlotte Hacker, Matthias Eiber
The recently introduced PSMA PET has developed as a powerful imaging tool for staging of prostate cancer. This case showed an intense uptake of Ga-PSMA in a soft-tissue mass of the rectus femoris muscle. Histopathology revealed the diagnosis of fasciitis nodularis. Therefore, it advises caution particularly in patients with solitary and atypical located lesions as they might not be indicative for metastatic prostate cancer, but eventually be caused by different conditions.
October 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27469937/intraneural-nodular-fasciitis-in-a-child-a-case-report-and-review-of-the-literature
#17
Kohei Kanaya, Kousuke Iba, Toshihiko Yamashita, Takuro Wada, Tadashi Hasegawa
We present the case of an 11-year-old boy with intraneural nodular fasciitis of the median nerve at the distal part of the carpal tunnel. Complete excision of the involved median nerve and cable grafting using 4 fascicular segments of the sural nerve was performed for persistent pain and numbness after initial resection of the tumor in piecemeal fashion. Pain and numbness were completely resolved and there was no evidence of recurrence 24 months after the final surgery.
September 2016: Journal of Hand Surgery
https://www.readbyqxmd.com/read/27462253/epibulbar-nodular-fasciitis
#18
David John Massop, Paul Adam Frederick, He J Li, Amy Lin
PURPOSE: To report a case of epibulbar nodular fasciitis in a 32-year-old female and provide context by reviewing the current literature. RESULTS: Using excisional biopsy, the patient was successfully diagnosed and treated for epibulbar nodular fasciitis. Upon follow-up, there has been no recurrence, consistent with the typical course for nodular fasciitis. CONCLUSIONS: Epibulbar nodular fasciitis is a rare process that can be successfully treated by surgical resection...
January 2016: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/27440725/jak1-stat3-signals-are-essential-effectors-of-the-usp6-tre17-oncogene-in-tumorigenesis
#19
Laura Quick, Robert Young, Ian C Henrich, Xiaoke Wang, Yan W Asmann, Andre M Oliveira, Margaret M Chou
Bone and soft tissue tumors (BSTT) are relatively poorly understood, hampering the development of effective therapies. Here we report a role for the ubiquitin-specific protease 6 (USP6)/TRE17 oncogene, which is overexpressed upon chromosome translocation in various human tumors, including aneurysmal bone cyst (ABC), and the related benign lesion nodular fasciitis. Ectopic expression of USP6 is known to drive formation of tumors, which recapitulate key features of ABC and nodular fasciitis; however, the identity of USP6's relevant substrates has been obscure...
September 15, 2016: Cancer Research
https://www.readbyqxmd.com/read/27408463/nodular-fasciitis-of-the-orofacial-region-an-uncommon-differential
#20
Arvind Krishnamurthy, Suhail Deen, Urmila Majhi
Nodular fasciitis is a benign proliferative spindle-cell lesion that presents as a rapidly growing mass arising from the subcutaneous fascia, leading it to be erroneously diagnosed as a sarcoma. These lesions commonly present in individuals in their third to fifth decades of life with no definite gender predilection. They are frequently located on the extremities and the trunk and infrequently in the head and neck region. Lesions in the orofacial region are uncommon. We describe an interesting case of orofacial nodular fasciitis in a 21-year-old boy that essentially summarises the clinical features and management of this pseudosarcomatous reactive proliferative lesion...
July 2016: Journal of Maxillofacial and Oral Surgery
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