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nodular fasciitis

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https://www.readbyqxmd.com/read/29787930/fibro-osseous-pseudotumor-of-digits-expanding-the-spectrum-of-clonal-transient-neoplasms-harboring-usp6-rearrangement
#1
Uta Flucke, Sarah J Shepard, Elise M Bekers, Roberto Tirabosco, Paul J van Diest, David Creytens, Joost M van Gorp
Fibro-osseous pseudotumors of the digits (FOPD) is a rare self-limiting lesion composed of bland looking hypercellular fibrous tissue and bone. USP6 rearrangement is a consistent genetic finding in aneurysmal bone cyst, nodular fasciitis, myositis ossificans and giant cell lesions of small bones. We report herein the occurrence of USP6 rearrangement in fibro-osseous pseudotumors of the digits using fluorescence in situ hybridization analysis (FISH). Of the five patients included, three were female and two were male...
May 12, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29773426/stem-cell-transcription-factor-sox2-in-synovial-sarcoma-and-other-soft-tissue-tumors
#2
Heba Zayed, Iver Petersen
BACKGROUND: SOX2 has gained considerable interest as a pluripotency inducing gene. Co-transfection of SOX2 together with NANOG, KLF4 and c-MYC into adult fibroblasts was able to generate pluripotent stem cells. SOX2 has been reported to be expressed in synovial sarcoma, a tumor being characterized by the SS18-SSX gene fusion forming part of the SWI/SNF chromatin remodeling complex that affects histone methylation. The role of SOX2 in this tumor type as well as other soft tissue tumor entities however is still poorly characterized...
May 4, 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29663743/intraspinal-intradural-nodular-fasciitis-mimicking-glioblastoma-metastasis-a-case-report
#3
Carl Moritz Zipser, Lars Füllbier, Rudi Beschorner, Hans Bösmüller, Ulf Ziemann, Marcos Soares Tatagiba, Ghazaleh Tabatabai, Benjamin Bender, Felix Behling
We report the case of a 78-year-old male patient suffering from right temporal glioblastoma with radiographic meningeal tumor spread. During the further course of the disease he developed a rapidly progressive paraplegia. An magnetic resonance imaging scan showed a contrast enhancing an intraspinal intradural lesion with compression of the myelon on segment Th 8/9. With a high suspicion of a spinal metastasis of the known glioblastoma, emergency spinal decompression and resection of the intradural mass was performed...
2018: Folia Neuropathologica
https://www.readbyqxmd.com/read/29661729/myositis-ossificans-another-condition-with-usp6-rearrangement-providing-evidence-of-a-relationship-with-nodular-fasciitis-and-aneurysmal-bone-cyst
#4
Elise M Bekers, Astrid Eijkelenboom, Katrien Grünberg, Rona C Roverts, Jacky W J de Rooy, Ingrid C M van der Geest, Joost M van Gorp, David Creytens, Uta Flucke
Myositis ossificans is defined as a self-limiting pseudotumor composed of reactive hypercellular fibrous tissue and bone. USP6 rearrangements have been identified as a consistent genetic driving event in aneurysmal bone cyst and nodular fasciitis. It is therefore an integral part of the diagnostic workup when dealing with (myo)fibroblastic lesions of soft tissue and bone. Two cases of myositis ossificans with USP6 rearrangement were published so far. We determine herein the incidence of USP6 rearrangement in myositis ossificans using USP6 fluorescence in situ hybridization analysis (FISH)...
January 12, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29658336/nodular-fasciitis-involving-the-palm
#5
M Emori, J Shimizu, Y Murahashi, E Mizushima, S Sugita, T Hasegawa, T Yamashita
Nodular fasciitis (NF) is a self-limiting fibrous neoplasm that can be mistaken for a soft tissue sarcoma. It is characterised by rapid growth, slight pain and local tenderness. Although it is frequently found in the forearm, a lesion distal to the wrist is quite rare. We present two unusual cases of NF involving the palm, supported by detecting ubiquitin specific protease 6 gene rearrangement. The first patient had non-intraneural NF presenting as peripheral neuropathy affecting the digital nerve while the second patient suffered from painless, non-tender NF in the palm, which had not regressed spontaneously during the five months prior to surgery...
April 16, 2018: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29623468/misses-and-near-misses-in-diagnosing-nodular-fasciitis-and-morphologically-related-reactive-myofibroblastic-proliferations-experience-of-a-referral-center-with-emphasis-on-frequency-of-usp6-gene-rearrangements
#6
Ramona Erber, Abbas Agaimy
Although harmless, reactive and benign neoplastic myo-/fibroblastic proliferations represent a diagnostic challenge in routine surgical pathology practice as reflected by their frequency among consultation cases. In addition to resembling each other, the prototypical nodular fasciitis (NF) and NF-like lesions can be mistaken for low-grade or aggressive sarcomas. USP6 translocation was reported recently as the molecular driver and potential diagnostic marker of NF. We reviewed 71 lesions with a diagnosis of NF (n = 48) or NF-like myofibroblastic proliferations (n = 23) and screened them for USP6 translocation by fluorescence in situ hybridization (FISH)...
April 5, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29617048/pseudosarcomatous-myofibroblastic-proliferations-of-the-genitourinary-tract-are-genetically-different-from-nodular-fasciitis-and-lack-usp6-ros1-and-etv6-gene-rearrangements
#7
Judith As Jebastin, Steven C Smith, Kyle D Perry, Nilesh S Gupta, Shaheen Alanee, Shannon Carskadon, Dhananjay A Chitale, Nallasivam Palanisamy, Sean R Williamson
AIMS: Pseudosarcomatous myofibroblastic proliferations of the genitourinary tract have a debatable relationship to inflammatory myofibroblastic tumour (generally lacking ALK rearrangement); however, they share several overlapping features with nodular fasciitis of soft tissue. Since rearrangement of the USP6 gene has been recently recognized as a recurrent alteration in soft tissue nodular fasciitis, and several other alternative gene fusions have been recently recognized in inflammatory myofibroblastic tumour, we studied whether USP6, ROS1, or ETV6 gene rearrangements were present in these lesions (12 cases)...
April 4, 2018: Histopathology
https://www.readbyqxmd.com/read/29549420/-morphological-spectrum-of-usp6-rearranged-lesions
#8
G Mechtersheimer, M Werner
USP6, also known as Tre-2 and TRE17, is an ubiquitase-specific proteinase that was identified more than two decades ago as a potential oncogene when it exhibited transforming properties upon overexpression in NIH 3T3 cells. Until recently, however, little was known about the function and the oncogenetic activation of USP6. The identification of rearrangements of the USP6 gene in aneurysmal bone cyst and in nodular fasciitis has not only led to a better understanding of the pathogenesis of these entities, but is also a useful tool in their diagnosis and differential diagnostic delineation from morphological mimics...
March 2018: Der Pathologe
https://www.readbyqxmd.com/read/29484039/nodular-fasciitis-of-the-breast-in-an-elderly-woman
#9
Jennifer A Knight, Katie N Hunt, Jodi Carter
Nodular fasciitis is a benign proliferation of fibroblasts and myofibroblasts most commonly found in the soft tissues of the upper extremities and the trunk of young to middle-aged adults. Nodular fasciitis is infrequently encountered in the breast and in the elderly. We report a case of a 69-year-old woman presenting with a palpable breast mass with imaging features that mimicked malignancy. Knowledge of this entity is important to allow proper radiological and pathologic concordance and patient management...
December 2017: Radiology Case Reports
https://www.readbyqxmd.com/read/29476440/biopsy-is-not-necessary-for-the-diagnosis-of-soft-tissue-hemangiomas
#10
Eugenio Rimondi, Andreas F Mavrogenis, Costantino Errani, Teresa Calabrò, Alberto Bazzocchi, Giancarlo Facchini, Salvatore Donatiello, Paolo Spinnato, Daniel Vanel, Ugo Albisinni, Patrizia Pelotti
OBJECTIVE: To describe the clinical and ultrasonography (US) findings of soft tissue hemangiomas, and to compare with the results of histologic diagnosis after US-guided biopsy. METHOD AND MATERIALS: We retrospectively studied the files of 97 patients (48 female, 49 male; mean age, 34 years; range 4-84 years) with soft tissue hemangiomas diagnosed from 2004 to 2011. Mean follow-up was 9 years (range 7-13 years). Clinical presentation included intermittent mild pain associated with a soft tissue swelling/palpable mass in all patients, chronic pain and increased local heat in 29 patients, local swelling and decreased range of motion of the adjacent joint in 45 patients, and all the above symptoms in 23 patients...
February 23, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29471212/nodular-fasciitis-mimicking-a-soft-tissue-sarcoma-a-case-report
#11
Vatsal Khanna, Manikandan Rajan, Trishya Reddy, Naveen Alexander, Parmasivam Surendran
INTRODUCTION: Nodular Fasciitis, also known as infiltrative or pseudosarcomatous fasciitis, is a benign soft tissue tumour of fibroblastic/myofibroblastic differentiation, that was first described in 1955 by Konwaler et al. PRESENTATION OF CASE: This is a case report of a 27-year old male with complaints of a swelling in the right axilla for 2 and ½ years measuring 12 cm × 10 cm. Chest X-Ray was normal. Magnetic Resonance Imaging of the right arm and chest showed an irregular mass in the axilla in the muscular-subcutaneous plane measuring 10...
2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29413661/differential-diagnosis-of-benign-spindle-cell-lesions
#12
REVIEW
Gaetano Magro
Spindle cell lesions of the breast cover a wide spectrum of diseases ranging from reactive tumor-like lesions to high-grade malignant tumors. The recognition of the benign spindle cell tumor-like lesions (nodular fasciitis; reactive spindle cell nodule after biopsy, inflammatory pseudotumor/inflammatory myofibroblastic tumor; fascicular variant of pseudoangiomatous stromal hyperplasia) and tumors (myofibroblastoma, benign fibroblastic spindle cell tumor, leiomyoma, schwannoma, spindle cell lipoma, solitary fibrous tumor, myxoma) is crucial to avoid confusion with morphologically similar but more aggressive bland-appearing spindle cell tumors, such as desmoid-type fibromatosis, low-grade (fibromatosis-like) spindle cell carcinoma, low-grade fibrosarcoma/myofibroblastic sarcoma and dermatofibrosarcoma protuberans...
March 2018: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/29259652/cytomorphological-spectrum-of-epididymal-nodules-an-institution-s-experience
#13
Jyotsna Naresh Bharti, Biswajit Dey, Jenna Bhattacharya, Shyama Jain
Background: Epididymal lesions are uncommon in clinical practice. Few case series has been described in the literature documenting the role of cytology in the evaluation of epididymal nodules. This study was undertaken to analyze the cytomorphology of epididymal nodules and to evaluate role of fine-needle aspiration biopsy (FNAB) in early definitive diagnosis of epididymal nodules. Materials and Methods: A total of seventy cases of epididymal nodules were aspirated over a period of 6 years in the Department of Pathology...
2017: CytoJournal
https://www.readbyqxmd.com/read/29228868/solitary-fibrous-tumors-in-pediatric-patients-a-rare-and-potentially-overdiagnosed-neoplasm-confirmed-by-stat6-immunohistochemistry
#14
Serena Y Tan, Linda J Szymanski, Carlos Galliani, David Parham, Eduardo Zambrano
Pathological diagnosis of solitary fibrous tumor (SFT) in the pediatric population is challenging, as it occurs uncommonly in this age-group and resembles other spindle cell neoplasms. SFT contains a NAB2-STAT6 fusion gene, which can be reliably detected using STAT6 immunohistochemistry. Positive staining is highly sensitive and specific. We sought to investigate the utility of STAT6 immunohistochemistry, to show how commonly SFT was historically recognized at 3 academic pediatric institutions, to reclassify them when appropriate, and to demonstrate features of major mimics of SFT...
January 1, 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/29210713/intradermal-proliferative-fasciitis-occurring-with-chondrodermatitis-nodularis-helicis
#15
Ashley Elsensohn, Sasha Getty, Jessica Shiu, Sébastien de Feraudy
Nodular fasciitis is a benign myofibroblastic tumor. Its uncommon variant, proliferative fasciitis (PF), can present in an even less common intradermal form. We report a case of intradermal PF of the ear in a 45-year-old man who presented with recurrent episodes of pain and swelling of the lesion. Histologic examination showed a dermal, nodular proliferation of ganglion-like basophilic fibroblasts with prominent nuclei and nucleoli, admixed with foamy histiocytes and areas of spindle cells arranged in intersecting fascicles in a fibromyxoid background...
February 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29198485/nodular-fasciitis-of-the-temporomandibular-joint-a-case-report
#16
I Jenkyn, A King, K A Moutasim, S Sharma
Nodular fasciitis is a relatively rare benign lesion of the soft tissue, which often presents in the fascia or deep subcutaneous tissues. It most commonly presents in the upper extremities and trunk and the head and neck region, particularly in younger patients. Its pathogenesis is poorly understood and it is predominantly thought to be a reactive lesion, although some have suggested that it may be a benign neoplasm. Advances in molecular testing and imaging have greatly assisted diagnosis. We discuss the benefits of ubiquitin-specific protease 6 (USP6) gene rearrangement testing and magnetic resonance imaging (MRI) to aid this uncommon diagnosis...
January 2018: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/29061731/ubiquitin-specific-protease-usp6-regulates-the-stability-of-the-c-jun-protein
#17
Lisheng Li, Hong Yang, Yan He, Ting Li, Jinan Feng, Wanze Chen, Lu Ao, Xuying Shi, Yingying Lin, Haoyun Liu, Enrun Zheng, Qiaofa Lin, Jingjing Bu, Yanhua Zeng, Min Zheng, Yan Xu, Zhijun Liao, Jiacheng Lin, Dexin Lin
The c- Jun gene encodes a transcription factor that has been implicated in many physiological and pathological processes. c-Jun is a highly unstable protein that is degraded through a ubiquitination/proteasome-dependent mechanism. However, the deubiquitinating enzyme (DUB) that regulates the stability of the c-Jun protein requires further investigation. Here, by screening a DUB expression library, we identified ubiquitin-specific protease 6 (USP6) and showed that it regulates the stability of the c-Jun protein in a manner depending on its enzyme activity...
January 15, 2018: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29058523/orbitofacial-dermatofibrosarcoma-protuberans-with-intranasal-extension
#18
Siti Nurhuda Sharudin, Siow Wei Tan, Nor Fadhilah Mohamad, Suresh Kumar Vasudevan, Hanizah Khairan, Y C Mun, Jothi Shanmuganathan
A 25-year-old Chinese woman presented with recurrent painless swelling over the left medial canthus region for 3 months and intranasal mass for an indeterminate duration. Initial incision biopsy of the mass was reported as nodular fasciitis but the lesion recurred 3 weeks later. Intraoperative findings during repeat biopsy showed a mass extending from the deep dermal tissue into the anterior orbit and polyp-like nasal mass. Histopathology findings were that of dermatofibrosarcoma protuberans (DFSP). The mass recurred 4 months later without orbital or intranasal recurrence...
October 23, 2017: Orbit
https://www.readbyqxmd.com/read/28993350/nodular-fasciitis-of-soft-tissue-over-the-mandible
#19
Daniel Yeomans, Ali Qureishi, Ketan Shah, Stuart Winter
Nodular fasciitis (NF) is an unusual, benign condition which can mimic more sinister, sarcomatous lesions both clinically and histologically. This case report presents a 35-year-old male, with a rapidly growing mass on the border of his left mandible, referred to a specialist head and neck unit. The initial presentation, radiology and cytology were initially inconclusive and the possibility of a malignant process was considered. Final histology was that of NF, the treatment of which is complete surgical excision...
October 9, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28937378/papillary-thyroid-carcinoma-with-nodular-fasciitis-like-stroma-a-rare-variant-with-distinctive-morphology
#20
Kavita Mardi
Papillary thyroid carcinoma (PTC) is a common malignancy with multiple variants, some of which are rarely encountered in routine surgical pathology practice. PTC with exuberant nodular fasciitis-like stroma or PTC with fibromatosis-like stroma is one such variant. This tumor is characterized by an abundant stromal component with an intervening epithelial component with the typical morphologic features of PTC. We describe gross and histopathological features of this rare variant of papillary carcinoma in a 38-year-old female and review the literature...
July 2017: Indian Journal of Pathology & Microbiology
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