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https://www.readbyqxmd.com/read/28925884/prevention-and-treatment-for-chemotherapy-induced-peripheral-neuropathy-therapies-based-on-cipn-mechanisms
#1
Lang-Yue Hu, Wen-Li Mi, Gen-Cheng Wu, Yan-Qing Wang, Qi-Liang Mao-Ying
BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is a progressive, enduring, and often irreversible adverse effect of many antineoplastic agents, among which sensory abnormities are common and the most suffering issues. The pathogenesis of CIPN has not been completely understood, and strategies for CIPN prevention and treatment are still open problems for medicine. OBJECTIVES: The objective of this paper is to review the mechanism-based therapies against sensory abnormities in CIPN...
September 15, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28925503/quantitative-analysis-of-mouse-dural-afferent-neurons-expressing-trpm8-vglut3-and-nf200
#2
Lynn Ren, Michelle Jaehee Chang, Zhiyu Zhang, Ajay Dhaka, Zhaohua Guo, Yu-Qing Cao
OBJECTIVE: To quantify the abundance of dural afferent neurons expressing transient receptor potential channel melastatin 8 (TRPM8), vesicular glutamate transporter 3 (VGLUT3), and neurofilament 200 (NF200) in adult mice. BACKGROUND: With the increasing use of mice as a model system to study headache mechanisms, it is important to understand the composition of dural afferent neurons in mice. In a previous study, we have measured the abundance of mouse dural afferent neurons that express neuropeptide calcitonin gene-related peptide as well as two TRP channels TRPV1 and TRPA1, respectively...
September 19, 2017: Headache
https://www.readbyqxmd.com/read/28923290/use-of-adult-sensory-panel-to-study-individual-differences-in-the-palatability-of-a-pediatric-hiv-treatment-drug
#3
Julie A Mennella, Phoebe S Mathew, Elizabeth D Lowenthal
PURPOSE: The recommended first-line treatment for young children infected with HIV includes the liquid formulation of the co-formulated protease inhibitors lopinavir/ritonavir (Kaletra(®) [Abbott Laboratories, Chicago, Illinois]). Clinical reports indicate that some children readily accept the taste of Kaletra, whereas others strongly reject it, which can deter therapeutic adherence and outcomes. METHODS: As a proof-of-concept approach, a sensory panel of genotyped adults was used to document the range of individual differences in the taste and palatability (hedonics) of the liquid formulation of Kaletra and other taste stimuli, including common excipients...
September 15, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28919709/puerarin-transport-across-rat-nasal-epithelial-cells-and-the-influence-of-compatibility-with-peoniflorin-and-menthol
#4
Lin Zhang, Shou-Ying Du, Yang Lu, Chang Liu, Hui-Chao Wu, Zhi-Hao Tian, Min Wang, Chang Yang
Nose-to-brain transport can provide an excellent pathway for drugs of the central nervous system. Consequently, how to make full use of this pathway in practical applications has become a focus of drug design. However, many aspects affecting drug delivery from the nose to the brain remain unclear. This study aimed to more deeply investigate the transport of puerarin and to explore the mechanism underlying the influence of compatible drugs on puerarin permeability in a primary cell model simulating the nasal mucosa...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28918457/effects-of-menthol-and-its-interaction-with-nicotine-conditioned-cue-on-nicotine-seeking-behavior-in-rats
#5
Erin Harrison, Lisa Biswas, Ramachandram Avusula, Meiyu Zhang, Yongzhen Gong, Xiu Liu
RATIONALE: Increasing clinical evidence suggests that menthol, a significant flavoring additive in tobacco products, may contribute to smoking and nicotine dependence. Relapse to smoking behavior presents a formidable challenge for the treatment of tobacco addiction. An unresolved issue is whether the mentholation of tobacco products precipitates relapse to tobacco use in abstinent smokers. OBJECTIVES: The present study examined the effects of menthol on the perseverance and relapse of nicotine-seeking behavior in rats...
September 16, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28915478/studying-the-interactive-effects-of-menthol-and-nicotine-among-youth-an-examination-using-e-cigarettes
#6
Suchitra Krishnan-Sarin, Barry G Green, Grace Kong, Dana A Cavallo, Peter Jatlow, Ralitza Gueorguieva, Eugenia Buta, Stephanie S O'Malley
BACKGROUND: Tobacco products containing menthol are widely used by youth. We used e-cigarettes to conduct an experimental evaluation of the independent and interactive effects of menthol and nicotine among youth. PROCEDURES: Pilot chemosensory experiments with fourteen e-cigarette users identified low (barely perceptible, 0.5%) and high (similar to commercial e-liquid, 3.5%) menthol concentrations. Sixty e-cigarette users were randomized to a nicotine concentration (0mg/ml, 6mg/ml, 12mg/ml) and participated in 3 laboratory sessions...
August 31, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28914377/the-permeability-enhancing-mechanism-of-menthol-on-skin-lipids-a-molecular-dynamics-simulation-study
#7
Huanjie Wang, Fancui Meng
The stratum corneum (SC), the outermost layer of skin, represents the primary barrier to molecules penetrating the skin. Menthol is widely used in clinical medicine as a penetration enhancer due to its high efficiency and relative safety. In this study, molecular dynamics simulations have been performed to investigate the effect of menthol molecules on the structural and permeability of both single component and ternary mixed bilayers. The lipid matrix is modeled as pure ceramide (CER2) or as a 2:2:1 mixture of CER2, cholesterol (CHOL), and free fatty acid (FFA)...
September 15, 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28890914/effect-of-menthol-preferring-status-on-response-to-intravenous-nicotine
#8
Elise E DeVito, Gerald W Valentine, Aryeh I Herman, Kevin P Jensen, Mehmet Sofuoglu
OBJECTIVES: Menthol, a flavoring agent, is found in approximately 90% of cigarettes, but at much higher levels in menthol than non-menthol cigarettes. Menthol is reportedly included in cigarettes for its cooling and soothing effects, but also additional actions that affect smokers' receipt and processing of nicotine. In this study we investigated the response to short-term abstinence and acute nicotine delivery in menthol-preferring and non-menthol-preferring smokers. METHODS: Nicotine dependent participants (N = 134) participated in an intravenous nicotine delivery session following overnight smoking abstinence...
October 2016: Tobacco Regulatory Science
https://www.readbyqxmd.com/read/28887460/novel-selective-potent-naphthyl-trpm8-antagonists-identified-through-a-combined-ligand-and-structure-based-virtual-screening-approach
#9
Andrea R Beccari, Marica Gemei, Matteo Lo Monte, Nazareno Menegatti, Marco Fanton, Alessandro Pedretti, Silvia Bovolenta, Cinzia Nucci, Angela Molteni, Andrea Rossignoli, Laura Brandolini, Alessandro Taddei, Lorena Za, Chiara Liberati, Giulio Vistoli
Transient receptor potential melastatin 8 (TRPM8), a nonselective cation channel, is the predominant mammalian cold temperature thermosensor and it is activated by cold temperatures and cooling compounds, such as menthol and icilin. Because of its role in cold allodynia, cold hyperalgesia and painful syndromes TRPM8 antagonists are currently being pursued as potential therapeutic agents for the treatment of pain hypersensitivity. Recently TRPM8 has been found in subsets of bladder sensory nerve fibres, providing an opportunity to understand and treat chronic hypersensitivity...
September 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28887427/tobacco-industry-tactics-in-preparing-for-menthol-ban
#10
Robert Schwartz, Michael Chaiton, Tracey Borland, Lori Diemert
No abstract text is available yet for this article.
September 8, 2017: Tobacco Control
https://www.readbyqxmd.com/read/28884423/electronic-cigarette-use-in-us-adults-at-risk-for-or-with-copd-analysis-from-two-observational-cohorts
#11
Russell P Bowler, Nadia N Hansel, Sean Jacobson, R Graham Barr, Barry J Make, MeiLan K Han, Wanda K O'Neal, Elizabeth C Oelsner, Richard Casaburi, Igor Barjaktarevic, Chris Cooper, Marilyn Foreman, Robert A Wise, Dawn L DeMeo, Edwin K Silverman, William Bailey, Kathleen F Harrington, Prescott G Woodruff, M Bradley Drummond
BACKGROUND: Electronic cigarettes (e-cigarettes) are battery-operated nicotine-delivery devices used by some smokers as a cessation tool as well as by never smokers. OBJECTIVE: To determine the usage of e-cigarettes in older adults at risk for or with chronic obstructive pulmonary disease (COPD). DESIGN: Prospective cohorts. PARTICIPANTS: COPDGene (N = 3536) and SPIROMICS (N = 1060) subjects who were current or former smokers aged 45-80...
September 7, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28883526/synthesis-high-throughput-screening-and-pharmacological-characterization-of-%C3%AE-lactam-derivatives-as-trpm8-antagonists
#12
Roberto de la Torre-Martínez, M Angeles Bonache, Pedro J Llabrés-Campaner, Beatriz Balsera, Asia Fernández-Carvajal, Gregorio Fernández-Ballester, Antonio Ferrer-Montiel, M Jesús Pérez de Vega, Rosario González-Muñiz
The mammalian transient receptor potential melastatin channel 8 (TRPM8), highly expressed in trigeminal and dorsal root ganglia, mediates the cooling sensation and plays an important role in the cold hypersensitivity characteristic of some types of neuropathic pain, as well as in cancer. Consequently, the identification of selective and potent ligands for TRPM8 is of great interest. Here, a series of compounds, having a β-lactam central scaffold, were prepared to explore the pharmacophore requirements for TRPM8 modulation...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28880223/how-social-care-beneficiaries-in-poland-rate-relative-harmfulness-of-various-tobacco-and-nicotine-containing-products
#13
Marek Milcarz, Kinga Polańska, Leokadia Bak-Romaniszyn, Dorota Kaleta
The aim of the study was to examine how social care beneficiaries rate the relative harmfulness of tobacco/nicotine-containing products compared to traditional cigarettes. This information is crucial for the development of effective tobacco control strategies targeting disadvantaged populations. The cross-sectional study covered 1817 respondents who were taking advantage of social aid services offered by the local social care institutions in the Piotrkowski district, via face-to-face interviews. The linear regression analysis indicated that relative to women, men consider slim cigarettes, smokeless tobacco and e-cigarettes to be more harmful than traditional cigarettes (p < 0...
September 7, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28865386/response-of-rhizobium-to-cd-exposure-a-volatile-perspective
#14
Paulo Cardoso, Magda Santos, Rosa Freitas, Sílvia M Rocha, Etelvina Figueira
The volatile metabolome of Rhizobium sp. strain E20-8 exposed to three concentrations of cadmium (2.5, 5.0 and 7.5 μM) was screened using comprehensive two-dimensional gas chromatography coupled to time of flight mass spectrometry (GC × GC-ToFMS), combined with headspace solid phase microextraction (HS-SPME). Cd exposure induced a global increase in the concentration of volatile organic compounds (VOCs) both intra and extracellularly. Peak areas of several linear alkanes, ketones, aldehydes, alcohols, terpenic and volatile sulfur compounds, and one ester (ethyl acetate), were especially increased when compared with the control condition (no Cd)...
August 30, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28862511/what-is-menthol
#15
(no author information available yet)
No abstract text is available yet for this article.
September 1, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28853018/improvement-of-the-pharmacological-activity-of-menthol-via-enzymatic-%C3%AE-anomer-selective-glycosylation
#16
Ha-Young Choi, Bo-Min Kim, Abubaker M A Morgan, Joong Su Kim, Won-Gon Kim
Menthol has a considerable cooling effect, but the use range of menthol is limited because of its extremely low solubility in water and inherent flavor. (-)-Menthol β-glucoside was determined to be more soluble in water (>27 times) than (-)-menthol α-glucoside; hence, β-anomer-selective glucosylation of menthol is necessary. The in vitro glycosylation of (-)-menthol by uridine diphosphate glycosyltransferase (BLC) from Bacillus licheniformis generated (-)-menthol β-glucoside and new (-)-menthol β-galactoside and (-)-menthol N-acetylglucosamine...
August 29, 2017: AMB Express
https://www.readbyqxmd.com/read/28845697/development-of-phospholipid-vesicle-based-permeation-assay-models-capable-of-evaluating-percutaneous-penetration-enhancing-effect
#17
Min Ma, Hong-Jie Di, Hui Zhang, Jun-Hong Yao, Jie Dong, Guo-Jun Yan, Hong-Zhi Qiao, Jun Chen
OBJECTIVES: The phospholipid vesicle-based permeation assay (PVPA) model has recently been introduced as an in vitro model which can mimic stratum corneum (SC) barriers to estimate the skin permeability of drugs. The aim of this study was to evaluate whether the PVPA model was suitable for the evaluation of penetration enhancing effect of skin penetration enhancers (PE). METHODS: The PVPA model was optimized by changing the lipid composition of both small liposomes (SL) and large liposomes (LL)...
August 28, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28836790/stabilizing-unstable-amorphous-menthol-through-inclusion-in-mesoporous-silica-hosts
#18
Teresa Cordeiro, Carmem Castiñeira, Davide Mendes, Florence Danède, João Sotomayor, Isabel M Fonseca, Marco Gomes da Silva, Alexandre Paiva, Susana Barreiros, M Margarida Cardoso, Maria T Viciosa, Natália T Correia, Madalena Dionisio
The amorphization of the readily crystallizable therapeutic ingredient and food additive, menthol, was successfully achieved by inclusion of neat menthol in mesoporous silica matrixes of 3.2 and 5.9 nm size pores. Menthol amorphization was confirmed by the calorimetric detection of a glass transition. The respective glass transition temperature, Tg = -54.3 °C, is in good agreement with the one predicted by the composition dependence of the Tg values determined for menthol:flurbiprofen therapeutic deep eutectic solvents (THEDESs)...
August 24, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28830420/a-randomised-controlled-two-centre-open-label-study-in-healthy-japanese-subjects-to-evaluate-the-effect-on-biomarkers-of-exposure-of-switching-from-a-conventional-cigarette-to-a-tobacco-heating-product
#19
Nathan Gale, Mike McEwan, Alison C Eldridge, Neil Sherwood, Edward Bowen, Simon McDermott, Emma Holmes, Andrew Hedge, Stuart Hossack, Oscar M Camacho, Graham Errington, John McAughey, James Murphy, Chuan Liu, Christopher J Proctor, Ian M Fearon
BACKGROUND: Smoking is a leading cause of numerous human disorders including lung cancer, chronic obstructive pulmonary disease, and atherosclerotic cardiovascular disease. The development of modified risk tobacco products (MRTPs) has been suggested as a possible way to reduce the risks of tobacco smoking by reducing exposure to cigarette smoke toxicants. This study is designed to investigate whether biomarkers of such exposure are reduced when smokers switch from smoking commercial cigarettes to using either a novel or a commercially-available tobacco heating product (THP)...
August 22, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28827946/topical-menthol-for-treatment-of-chemotherapy-induced-peripheral-neuropathy
#20
Alessio Cortellini, Lucilla Verna, Katia Cannita, Luca Napoleoni, Alessandro Parisi, Corrado Ficorella, Giampiero Porzio
Chemotherapy-induced peripheral neuropathy is a frequent treatment-limiting factor that significantly impairs patients' everyday life, also because of a lack of valid palliative options. Here, we report a case of a male patient with a history of metastatic colon cancer and previous chemotherapies. He came to our attention with a peripheral neuropathy that impaired his quality of life and could limit the further line of chemotherapy. We treated the neuropathy with menthol aqueous cream with benefit.
July 2017: Indian Journal of Palliative Care
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