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https://www.readbyqxmd.com/read/28213947/select-noxious-stimuli-induce-changes-on-corneal-nerve-morphology
#1
Deborah M Hegarty, Sam M Hermes, Katherine Yang, Sue A Aicher
The surface of the cornea contains the highest density of nociceptive nerves of any tissue in the body. These nerves are responsive to a variety of modalities of noxious stimuli and can signal pain even when activated by low threshold stimulation. Injury of corneal nerves can lead to altered nerve morphology, including neuropathic changes which can be associated with chronic pain. Emerging technologies that allow imaging of corneal nerves in vivo are spawning questions regarding the relationship between corneal nerve density, morphology and function...
February 18, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28213106/oral-treatment-with-essential-oil-of-hyptis-spicigera-lam-lamiaceae-reduces-acute-pain-and-inflammation-in-mice-potential-interactions-with-transient-receptor-potential-trp-ion-channels
#2
Róli Rodrigues Simões, Igor Dos Santos Coelho, Stella Célio Junqueira, Glauce Regina Pigatto, Marcos José Salvador, Adair Roberto Soares Santos, Felipe Meira de Faria
ETHNOPHARMACOLOGICAL RELEVANCE: The genus Hyptis comprehends almost 400 species widespread in tropical and temperate regions of America. The use of Hyptis spicigera Lam. (Lamiaceae) is reported in traditional medicine due to its gastroprotective, anti-inflammatory and analgesic properties. AIM OF THE STUDY: The rationale of this study was to investigate the potential use of the essential oil of H. spicigera (EOHs) as analgesic. MATERIAL AND METHODS: The antinociceptive effect of EOHs was verified analyzing acute nocifensive behavior of mice induced by chemical noxious stimuli [i...
February 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28210778/threshold-dose-for-behavioral-discrimination-of-cigarette-nicotine-content-in-menthol-vs-non-menthol-smokers
#3
Kenneth A Perkins, Nicole Kunkle, Joshua L Karelitz
RATIONALE: The lowest threshold content (or "dose") of nicotine discriminated in cigarettes may differ due to menthol preference. OBJECTIVES: Menthol and non-menthol Spectrum research cigarettes differing in nicotine content were used to determine discrimination thresholds. METHODS: Dependent smokers preferring menthol (n = 40) or non-menthol (n = 21) brands were tested on ability to discriminate cigarettes (matched for their menthol preference) with nicotine contents of 16-17, 11-12, 5, 2, and 1 mg/g, one per session, from an "ultra-low" cigarette with 0...
February 16, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28208614/a-comparative-analysis-of-the-chemical-composition-anti-inflammatory-and-antinociceptive-effects-of-the-essential-oils-from-three-species-of-mentha-cultivated-in-romania
#4
Cristina Mogosan, Oliviu Vostinaru, Radu Oprean, Codruta Heghes, Lorena Filip, Georgeta Balica, Radu Ioan Moldovan
This work was aimed at correlating the chemotype of three Mentha species cultivated in Romania with an in vivo study of the anti-inflammatory and antinociceptive effects of essential oils. The selected species were Mentha piperita L. var. pallescens (white peppermint), Mentha spicata L. subsp. crispata (spearmint), and Mentha suaveolens Ehrh. (pineapple mint). Qualitative and quantitative analysis of the essential oils isolated from the selected Mentha species was performed by gas chromatography coupled with mass spectrometry (GC-MS)...
February 10, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28202080/mentholation-affects-the-cigarette-microbiota-by-selecting-for-bacteria-resistant-to-harsh-environmental-conditions-and-selecting-against-potential-bacterial-pathogens
#5
Jessica Chopyk, Suhana Chattopadhyay, Prachi Kulkarni, Emma Claye, Kelsey R Babik, Molly C Reid, Eoghan M Smyth, Lauren E Hittle, Joseph N Paulson, Raul Cruz-Cano, Mihai Pop, Stephanie S Buehler, Pamela I Clark, Amy R Sapkota, Emmanuel F Mongodin
BACKGROUND: There is a paucity of data regarding the microbial constituents of tobacco products and their impacts on public health. Moreover, there has been no comparative characterization performed on the bacterial microbiota associated with the addition of menthol, an additive that has been used by tobacco manufacturers for nearly a century. To address this knowledge gap, we conducted bacterial community profiling on tobacco from user- and custom-mentholated/non-mentholated cigarette pairs, as well as a commercially-mentholated product...
February 15, 2017: Microbiome
https://www.readbyqxmd.com/read/28194934/continuous-flow-1-h-and-13-c-nmr-spectroscopy-in-microfluidic-stripline-nmr-chips
#6
Anna Jo Oosthoek-de Vries, Jacob Bart, Roald M Tiggelaar, Johannes W G Janssen, P Jan M van Bentum, Han J G E Gardeniers, Arno P M Kentgens
Microfluidic stripline NMR technology not only allows for NMR experiments to be performed on small sample volumes in the submicroliter range, but also experiments can easily be performed in continuous flow because of the stripline's favorable geometry. In this study we demonstrate the possibility of dual-channel operation of a microfluidic stripline NMR setup showing one- and two-dimensional (1)H, (13)C and heteronuclear NMR experiments under continuous flow. We performed experiments on ethyl crotonate and menthol, using three different types of NMR chips aiming for straightforward microfluidic connectivity...
February 6, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28188954/comparative-glandular-trichome-transcriptome-based-gene-characterization-reveals-reasons-for-differential-menthol-biosynthesis-in-mentha-species
#7
Md Qussen Akhtar, Nida Qamar, Pallavi Yadav, Pallavi Kulkarni, Ajay Kumar, Ajit Kumar Shasany
The genes involved in menthol biosynthesis are reported earlier in Mentha × piperita. But the information on these genes is not available in Mentha arvensis. To bridge the gap in knowledge on differential biosynthesis of monoterpenes leading to compositional variation in the essential oil of these species, a comparative transcriptome analysis of the glandular trichome was carried out. In addition to the MVA and MEP pathway genes, about 210 and 196 different terpene synthases (TPS) transcripts were identified from annotation in M...
February 11, 2017: Physiologia Plantarum
https://www.readbyqxmd.com/read/28188607/enhanced-skin-permeation-of-glabridin-using-eutectic-mixture-based-nanoemulsion
#8
Chen Liu, Jin Hu, Hong Sui, Qipeng Zhao, Xia Zhang, Wenping Wang
This study aimed to investigate the performance of the eutectic mixture of menthol and camphor (1:1, w/w) in nanoemulsion formulation for enhanced transdermal penetration of water-insoluble glabridin. Glabridin solubility in different media was determined by a shaking bottle method. The pseudoternary phase diagrams of the oil phase (drug-loaded eutectic mixture or IPM), the surfactant (Tween 80:glycerol = 2:1, w/w), and water were constructed using the aqueous titration method. The obtained glabridin nanoemulsions were characterized and compared on their particle sizes, in vitro and in vivo penetration performance on rat skin, and storage stability...
February 10, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28180899/trends-in-and-characteristics-of-marijuana-and-menthol-cigarette-use-among-current-cigarette-smokers-2005-2014
#9
Gillian L Schauer, Erica N Peters, Zachary R Rosenberry, Hyoshin Kim
No abstract text is available yet for this article.
January 6, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28179946/diastereoselective-anodic-hetero-and-homo-coupling-of-menthol-8-methylmenthol-and-8-phenylmenthol-2-alkylmalonates
#10
Matthias C Letzel, Hans J Schäfer, Roland Fröhlich
Diastereoselective radical coupling was achieved with chiral auxiliaries. The radicals were generated by anodic decarboxylation of five malonic acid derivatives. These were prepared from benzyl malonates and four menthol auxiliaries. Coelectrolyses with 3,3-dimethylbutanoic acid in methanol at platinum electrodes in an undivided cell afforded hetero-coupling products in 22-69% yield with a diastereoselectivity ranging from 5 to 65% de. Electrolyses without a coacid led to diastereomeric homo-coupling products in 21-50% yield with ratios of diastereomers being 1...
2017: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28177594/investigation-of-chemosensitivity-during-and-after-an-acute-cold
#11
Robert Pellegrino, Ute Walliczek-Dworschak, Gudrun Winter, David Hull, Thomas Hummel
BACKGROUND: Viral rhinitis (the "common" cold) is a frequent worldwide disease. Olfactory dysfunction is one complication that arises during infection, which in most cases heals up spontaneously upon recovery, whereas in some cases it may persist as a partial or total loss of olfaction. The aim of this prospective study was to investigate the change of other chemosensory systems during a cold. METHODS: Fifty-eight patients (age 18 to 69 years) with an acute cold were compared to a healthy control group (n = 59; age 19 to 63 years)...
February 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28177498/effects-of-switching-to-the-menthol-tobacco-heating-system-2-2-smoking-abstinence-or-continued-cigarette-smoking-on-clinically-relevant-risk-markers-a-randomized-controlled-open-label-multicenter-study-in-sequential-confinement-and-ambulatory-settings-part
#12
Frank Lüdicke, Patrick Picavet, Gizelle Baker, Christelle Haziza, Valerie Poux, Nicola Lama, Rolf Weitkunat
No abstract text is available yet for this article.
February 8, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28177489/effects-of-switching-to-the-tobacco-heating-system-2-2-menthol-smoking-abstinence-or-continued-cigarette-smoking-on-biomarkers-of-exposure-a-randomized-controlled-open-label-multicenter-study-in-sequential-confinement-and-ambulatory-settings-part-1
#13
Frank Lüdicke, Patrick Picavet, Gizelle Baker, Christelle Haziza, Valerie Poux, Nicola Lama, Rolf Weitkunat
No abstract text is available yet for this article.
February 8, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28176464/enantioselective-reduction-of-citral-isomers-in-ncr-ene-reductase-analysis-of-an-active-site-mutant-library
#14
Nico Kress, Johanna Rapp, Bernhard Hauer
A deepened understanding of the > 99 % (S)-selective NCR ene reductase catalyzed reduction of both isomers of citral was generated by active site mutational studies and docking. Though structurally almost similar, the (E/Z)-isomers of citral showed a significantly varying selectivity response to introduced mutations. While it was possible to invert (E) citral reduction enantioselectivity to an e.e. of 46 % (R) by a W66A mutation, for (Z)-citral it remained ≥ 88 % (S) for all analyzed NCR single variants...
February 8, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28164404/mysterious-decomposition-of-alkoxyphosphonium-chlorides-postulated-involvement-of-the-hcl2-anion-and-its-capture-in-the-solid-state
#15
Kirill Nikitin, Helge Müller-Bunz, Jimmy Muldoon, Declan G Gilheany
P-Alkoxyphosphonium (AP) chlorides were generated by reacting P-chlorophosphonium chlorides with alcohols. Their well-known spontaneous Arbuzov-type collapse leading to phosphine oxides was studied and its rate found to be dependent on a number of factors in an unexpected fashion: it is inversely proportional to the initial concentration and it shows strong dependence on the acidity of the media but is not very sensitive to the presence of base. To explain these observations, we evoke a self-inhibition model with the formation of the less nucleophilic hydrodichloride anion HCl2 in solution...
February 6, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28163170/stroke-risk-among-menthol-versus-non-menthol-cigarette-smokers-in-the-united-states-analysis-of-the-national-health-and-nutrition-examination-survey-nhanes
#16
Cynthia Van Landingham, William Fuller, Greg Mariano, Kristin Marano, Geoffrey Curtin, Sandra I Sulsky
Though available evidence is relatively consistent in showing no additional health effects among smokers due to menthol in cigarettes, two studies reported conflicting results for stroke risk using different subsets of NHANES data. We investigated reasons for the differences in these reports by analyzing NHANES cycles conducted between 1999 and 2012, combined and in subsets. Adjusted odds ratios (AOR) and 95% confidence intervals (CI) from three different survey logistic regression models compare risk of reported stroke diagnoses among menthol and non-menthol cigarette smokers...
February 3, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28154307/molecular-interaction-between-intercellular-lipids-in-the-stratum-corneum-and-l-menthol-as-analyzed-by-synchrotron-x-ray-diffraction
#17
Shinya Yoshida, Yasuko Obata, Yoshinori Onuki, Shunichi Utsumi, Noboru Ohta, Hiroshi Takahashi, Kozo Takayama
l-Menthol increases drug partitioning on the surface of skin, diffusion of drugs in the skin, and lipid fluidity in the stratum corneum and alters the rigidly arranged lipid structure of intercellular lipids. However, l-menthol is a solid at room temperature, and it is difficult to determine the effects of l-menthol alone. In this study, we vaporized l-menthol in order to avoid the effects of solvents. The vaporized l-menthol was applied to the stratum corneum or lipid models comprising composed of ceramides (CER) [EOS], the longest lipid acyl chain of the ceramides in the stratum corneum lipids that is associated with the barrier function of the skin; CER [NS], the shorter lipid acyl chain of the ceramides, and the most components in the stratum corneum of the intercellular lipids that is associated with water retention in the intercellular lipid structure of the stratum corneum; cholesterol; and palmitic acid...
2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28153673/quantitative-analysis-of-menthol-in-human-urine-using-solid-phase-microextraction-and-stable-isotope-dilution-gas-chromatography-mass-spectrometry
#18
Wenlin Huang, Benjamin C Blount, Clifford H Watson, Christina Watson, David M Chambers
To accurately measure menthol levels in human urine, we developed a method using gas chromatography/electron ionization mass spectrometry with menthol-d4 stable isotope internal standardization. We used solid phase microextraction (SPME) headspace sampling for collection, preconcentration and automation. Conjugated forms of menthol were released using β-glucuronidase/sulfatase to allow for measuring total menthol. Additionally, we processed the specimens without using β-glucuronidase/sulfatase to quantify the levels of unconjugated (free) menthol in urine...
December 13, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28145604/comparison-of-the-effect-of-ionic-liquids-containing-hexafluorophosphate-and-trifluoroacetate-anions-on-the-inhibition-of-growth-and-oxidative-stress-in-spring-barley-and-common-radish
#19
Robert Biczak, Barbara Pawłowska, Joanna Feder-Kubis, Arkadiusz Telesiński
Ionic liquids (ILs) are a group of chemical compounds, with chemical properties, which are of great interest to various fields of science and industry. However, commercial use of these substances raises concern as they may threaten the natural ecosystems. This study used two types of (-)-menthol-containing chiral imidazolium ionic liquids (CILs): 1-[(1R,2S,5R)-(-)-menthoxymethyl]-3-methylimidazolium hexafluorophoshate [Im-Men][PF6 ] and 1-[(1R,2S,5R)-(-)-menthoxymethyl]-3-methylimidazolium trifluoroacetate [Im-Men][CF3 CO2 ]...
February 1, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28138709/trpm8-downregulation-by-angiotensin-ii-in-vascular-smooth-muscle-cells-is-involved-in-hypertension
#20
Fang Huang, Min Ni, Jing-Ming Zhang, Dong-Jie Li, Fu-Ming Shen
Angiotensin II (Ang II)-induced injury of vascular smooth muscle cells (VSMCs) serves an important role in hypertension and other cardiovascular disorders. Transient receptor potential melastatin 8 (TRPM8) is a thermally‑regulated Ca2+‑permeable channel that is activated by reduced body temperature. Although several recent studies have revealed the regulatory effect of TRPM8 in vascular tone and hypertension, the precise role of TRPM8 in dysfunction of vascular smooth muscle cells (VSMCs) induced by Ang II remains elusive...
January 30, 2017: Molecular Medicine Reports
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