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https://www.readbyqxmd.com/read/27904078/effect-of-nerolidol-and-or-levulinic-acid-on-the-thermotropic-behavior-of-lipid-lamellar-structures-in-the-stratum-corneum
#1
Shunichi Utsumi, Tomohiro Nakamura, Yasuko Obata, Noboru Ohta, Kozo Takayama
Permeation enhancers are required to deliver drugs through the skin efficiently and maintain effective blood concentrations. Studies of the barrier function of the stratum corneum using l-menthol, a monocyclic monoterpene widely used in medicines and foods, have revealed an interaction between characteristic intercellular lipid structures in the stratum corneum and permeation enhancers. The variety of permeation enhancers that can be used to contribute to transdermal delivery systems beyond l-menthol is increasing...
2016: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27899298/mechanisms-and-time-course-of-menthol-induced-cutaneous-vasodilation
#2
Daniel H Craighead, Nathaniel B McCartney, James H Tumlinson, Lacy M Alexander
Menthol is a vasoactive compound that is widely used in topical analgesic agents. Menthol induces cutaneous vasodilation, however the underlying mechanisms are unknown. Determining the rates of appearance and clearance of menthol in the skin is important for optimizing topical treatment formulation and dosing. The purpose of this study was to determine the mechanisms contributing to menthol-mediated cutaneous vasodilation and to establish a time course for menthol appearance/clearance in the skin. Ten young (23±1years, 5 males 5 females) subjects participated in two protocols...
November 26, 2016: Microvascular Research
https://www.readbyqxmd.com/read/27891154/preparation-of-ecofriendly-formulations-containing-biologically-active-monoterpenes-with-their-fumigant-and-residual-toxicities-against-adults-of-culex-pipiens
#3
Mohamed E I Badawy, Nehad E M Taktak, Osama M Awad, Souraya A Elfiki, Nadia E Abou El-Ela
Different mixtures of monoterpenes (ketone, alcohol, and alkene) were loaded on paper discs and wax and their knockdown activities were evaluated against Culex pipiens adults. Some individual monoterpenes were also evaluated by residual toxicity technique. Citronella oil as a reference was also loaded separately or in combination with monoterpenes on paper discs and wax. The ketone monoterpenes mixture (camphor, menthone, carvone, and fenchone) on paper discs was the most active (KT50 = 17.20 min) followed by ketone monoterpenes with citronella oil (KT50 = 20...
2016: Journal of Tropical Medicine
https://www.readbyqxmd.com/read/27887033/skin-irritation-and-sensitization-potential-of-fixed-dose-combination-of-diclofenac-1-and-menthol-3-topical-gel-results-of-two-phase-i-patch-studies
#4
D Jeffery Liu, A Collaku, J S Dosik
Phase I, randomized, controlled patch studies were conducted to evaluate skin sensitization and irritation potential of a new gel formulation containing 1% diclofenac and 3% menthol as a fixed-combination product.In study A, healthy volunteers were exposed to 4 test patches containing 1% diclofenac+3% menthol, diclofenac, menthol, or placebo gels during an induction (nine 48 to 72-h applications) and challenge phase (one 48-h application). Some subjects were re-challenged to evaluate suspected sensitization...
November 25, 2016: Drug Research
https://www.readbyqxmd.com/read/27872344/impact-of-non-menthol-flavours-in-tobacco-products-on-perceptions-and-use-among-youth-young-adults-and-adults-a-systematic-review
#5
REVIEW
Li-Ling Huang, Hannah M Baker, Clare Meernik, Leah M Ranney, Amanda Richardson, Adam O Goldstein
OBJECTIVE: This systematic review examines the impact of non-menthol flavours in tobacco products on tobacco use perceptions and behaviours among youth, young adults and adults. DATA SOURCES: English-language peer-reviewed publications indexed in 4 databases were searched through April 2016. STUDY SELECTION: A search strategy was developed related to tobacco products and flavours. Of 1688 articles identified, we excluded articles that were not English-language, were not peer-reviewed, were qualitative, assessed menthol-flavoured tobacco products only and did not contain original data on outcomes that assessed the impact of flavours in tobacco products on perceptions and use behaviour...
November 21, 2016: Tobacco Control
https://www.readbyqxmd.com/read/27862339/novel-trpm8-agonist-cooling-compound-against-chronic-itch-results-from-a-randomized-double-blind-controlled-pilot-study-in-dry-skin
#6
S Ständer, M Augustin, D Roggenkamp, C Blome, T Heitkemper, A C Worthmann, G Neufang
BACKGROUND: Patients suffering from chronic pruritus (CP) due to dry skin with are often applying emollients containing menthol. However, topical menthol may be irritating and of weak potency in severe pruritus. Two TRPM8 agonists, (1R,2S,5R)-N-(2-(2-pyridinyl)ethyl)-2-ispropyl-5-methylcyclohexancarboxamide and menthoxypropan-ediol, combined as Cooling Compound (CC) have shown stronger activation of TRPM8 than menthol. OBJECTIVES: Objective of this study was to evaluate the efficacy and safety of CC in alleviating pruritus in patients with dry itchy skin...
November 11, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27859725/effects-of-menthol-application-on-the-skin-during-prolonged-immersion-in-swimmers-and-controls
#7
P G Botonis, N D Geladas, S N Kounalakis, E D Cherouveim, M D Koskolou
We hypothesized that menthol application on the skin would enhance vasoconstriction of subjects immersed in cool water, which would reduce heat loss and rectal temperature (Tre) cooling rate. Furthermore, it was hypothesized that this effect would be greater in individuals acclimatized to immersion in 24 °C water, such as swimmers. Seven swimmers (SW) and seven physical education students (CON) cycled at 60% VO2 max until Tre attained 38 °C, and were then immediately immersed in stirred water maintained at 24 °C on two occasions: without (NM) and with (M; 4...
November 18, 2016: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/27858306/menthol-a-fresh-ergogenic-aid-for-athletic-performance
#8
Christopher J Stevens, Russ Best
The application of menthol has recently been researched as a performance-enhancing aid for various aspects of athletic performance including endurance, speed, strength and joint range of motion. A range of application methods has been used including a mouth rinse, ingestion of a beverage containing menthol or external application to the skin or clothing via a gel or spray. The majority of research has focussed on the use of menthol to impart a cooling sensation on athletes performing endurance exercise in the heat...
November 17, 2016: Sports Medicine
https://www.readbyqxmd.com/read/27856997/association-between-menthol-flavoured-cigarette-smoking-and-flavoured-little-cigar-and-cigarillo-use-among-african-american-hispanic-and-white-young-and-middle-aged-adult-smokers
#9
K Sterling, C Fryer, I Pagano, D Jones, P Fagan
OBJECTIVES: Flavour additives in cigarettes and little cigars and cigarillos (LCCs), which influence smokers' risk perceptions, may reinforce dual flavoured tobacco use. We examined the association among mentholated cigarette use, risk perceptions for flavour additives in LCCs and flavoured LCC smoking behaviour. METHODS: Data from a national probability sample of 964 young and middle-aged adult current cigarette smokers were analysed. Multinomial logistic regression models examined the relationship among mentholated cigarette smoking, risk perceptions and current flavoured LCC use for the analytic sample and gender and race/ethnicity...
November 2016: Tobacco Control
https://www.readbyqxmd.com/read/27845159/evaluation-of-the-tobacco-heating-system-2-2-part-9-application-of-systems-pharmacology-to-identify-exposure-response-markers-in-peripheral-blood-of-smokers-switching-to-ths2-2
#10
Florian Martin, Marja Talikka, Nikolai V Ivanov, Christelle Haziza, Julia Hoeng, Manuel C Peitsch
As part of current harm reduction strategies, candidate modified risk tobacco products (MRTP) are developed to offer adult smokers who want to continue using tobacco product an alternative to cigarettes while potentially reducing individual risk and population harm compared to smoking cigarettes. One of these candidate MRTPs is the Tobacco Heating System (THS) 2.2 which does not burn tobacco, but instead heats it, thus producing significantly reduced levels of harmful and potentially harmful constituents (HPHC) compared with combustible cigarettes (CC)...
November 11, 2016: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/27818348/evaluation-of-the-tobacco-heating-system-2-2-part-6-90-day-oecd-413-rat-inhalation-study-with-systems-toxicology-endpoints-demonstrates-reduced-exposure-effects-of-a-mentholated-version-compared-with-mentholated-and-non-mentholated-cigarette-smoke
#11
Alberto Oviedo, Stefan Lebrun, Ulrike Kogel, Jenny Ho, Wei Teck Tan, Bjoern Titz, Patrice Leroy, Gregory Vuillaume, Monali Bera, Florian Martin, Gregory Rodrigo, Marco Esposito, Ruth Dempsey, Nikolai V Ivanov, Julia Hoeng, Manuel C Peitsch, Patrick Vanscheeuwijck
The toxicity of a mentholated version of the Tobacco Heating System (THS2.2M), a candidate modified risk tobacco product (MRTP), was characterized in a 90-day OECD inhalation study. Differential gene and protein expression analysis of nasal epithelium and lung tissue was also performed to record exposure effects at the molecular level. Rats were exposed to filtered air (sham), to THS2.2M (at 15, 23 and 50 μg nicotine/l), to two mentholated reference cigarettes (MRC) (at 23 μg nicotine/l), or to the 3R4F reference cigarette (at 23 μg nicotine/l)...
November 3, 2016: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/27818347/evaluation-of-the-tobacco-heating-system-2-2-part-7-systems-toxicological-assessment-of-a-mentholated-version-revealed-reduced-cellular-and-molecular-exposure-effects-compared-with-mentholated-and-non-mentholated-cigarette-smoke
#12
Ulrike Kogel, Bjoern Titz, Walter K Schlage, Catherine Nury, Florian Martin, Alberto Oviedo, Stefan Lebrun, Ashraf Elamin, Emmanuel Guedj, Keyur Trivedi, Nikolai V Ivanov, Patrick Vanscheeuwijck, Manuel C Peitsch, Julia Hoeng
Modified risk tobacco products (MRTPs) are being developed with the aim of reducing smoking-related health risks. The Tobacco Heating System 2.2 (THS2.2) is a candidate MRTP that uses the heat-not-burn principle. Here, systems toxicology approaches were engaged to assess the respiratory effects of mentholated THS2.2 (THS2.2M) in a 90-day rat inhalation study (OECD test guideline 413). The standard endpoints were complemented by transcriptomics and quantitative proteomics analyses of respiratory nasal epithelium and lung tissue and by lipidomics analysis of lung tissue...
November 3, 2016: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/27816672/evaluation-of-the-tobacco-heating-system-2-2-part-8-5-day-randomized-reduced-exposure-clinical-study-in-poland
#13
Christelle Haziza, Guillaume de La Bourdonnaye, Dimitra Skiada, Jacek Ancerewicz, Gizelle Baker, Patrick Picavet, Frank Lüdicke
The Tobacco Heating System (THS) 2.2, a candidate Modified Risk Tobacco Product (MRTP), is designed to heat tobacco without burning it. Tobacco is heated in order to reduce the formation of harmful and potentially harmful constituents (HPHC), and reduce the consequent exposure, compared with combustible cigarettes (CC). In this 5-day exposure, controlled, parallel-group, open-label clinical study, 160 smoking, healthy subjects were randomized to three groups and asked to: (1) switch from CCs to THS 2.2 (THS group; 80 participants); (2) continue to use their own non-menthol CC brand (CC group; 41 participants); or (3) to refrain from smoking (SA group; 39 participants)...
November 2, 2016: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/27803472/effect-of-surfactants-and-thickeners-on-the-stability-of-menthol-diphenhydramine-cream-identified-by-magnetic-resonance-imaging
#14
Yoshinori Onuki, Masamitsu Yokokawa, Shunichi Utsumi, Yasuko Obata, Yoshiaki Machida, Chieko Seike, Yoshihiro Hayashi, Kozo Takayama
A menthol-diphenhydramine cream is prepared in hospital pharmacies and then prescribed to patients for the treatment of pruritus associated with chronic kidney disease. The purpose of this study is to design a stable formulation without any concern about phase separation during its clinical use on patients. As a preventive measure against phase separation, various surfactants and thickeners were incorporated into the creams. The test creams were stored at 40°C, and then their phase separation behaviors were monitored...
2016: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27794065/flavoured-non-cigarette-tobacco-product-use-among-us-adults-2013-2014
#15
Michèle G Bonhomme, Enver Holder-Hayes, Bridget K Ambrose, Cindy Tworek, Shari P Feirman, Brian A King, Benjamin J Apelberg
INTRODUCTION: Limited data exist on flavoured non-cigarette tobacco product (NCTP) use among US adults. METHODS: Data from the 2013 to 2014 National Adult Tobacco Survey (N=75 233), a landline and cellular telephone survey of US adults aged ≥18, were assessed to estimate past 30-day NCTP use, flavoured NCTP use and flavour types using bivariate analyses. RESULTS: During 2013-2014, 14.4% of US adults were past 30-day NCTP users. Nationally, an estimated 10...
October 28, 2016: Tobacco Control
https://www.readbyqxmd.com/read/27768312/a-multiscale-study-on-the-penetration-enhancement-mechanism-of-menthol-to-osthole
#16
Shufang Yang, Ran Wang, Guang Wan, Zhimin Wu, Shujuan Guo, Xingxing Dai, Xinyuan Shi, Yanjiang Qiao
Menthol is a widely used penetration enhancer in clinical medicine due to its high efficiency and relative safety. However, details of the penetration enhancement mechanism of menthol on molecular level is rarely involved in the discussion. In this work, the penetration enhancement (PE) mechanism of menthol is explored by a multiscale method containing molecular dynamics simulations, in vitro penetration experiments and transmission electron microscopy. Osthole is chosen to be the tested drug due to its common-using in external preparations and its representative-accompanying with menthol as a PE in the preparations...
October 21, 2016: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/27765744/ion-channel-mechanisms-of-rat-tail-artery-contraction-relaxation-by-menthol-involving-respectively-trpm8-activation-and-l-type-ca2-channel-inhibition
#17
Donal Melanaphy, Christopher D Johnson, Maxim V Kustov, Conall A Watson, Lyudmyla Borysova, Theodor V Burdyga, Alexander V Zholos
Transient receptor potential melastatin 8 (TRPM8) is the principal cold and menthol receptor channel. Characterized primarily for its cold-sensing role in sensory neurons, it is expressed and functional in several nonneuronal tissues, including vasculature. We previously demonstrated that menthol causes variable mechanical responses (vasoconstriction, vasodilatation, or biphasic reactions) in isolated arteries, depending on vascular tone. Here we aimed to dissect the specific ion channel mechanisms and corresponding Ca(2+) signaling pathways underlying such complex responses to menthol and other TRPM8 ligands in rat tail artery myocytes using patch-clamp electrophysiology, confocal Ca(2+) imaging, and ratiometric Ca(2+) recording...
December 1, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27744170/one-step-photochemical-synthesis-of-clean-surfaced-sponge-like-porous-platinum-with-high-catalytic-performances
#18
Xing Kong, Hongliang Cao, Chang Li, Xin Chen
HYPOTHESIS: Template-free and surfactant-free strategies are highly desirable, which might be used for high efficient platinum catalyst developments. EXPERIMENTS: In this work, a facile one step photochemical synthesis method was developed to prepare sponge-like porous platinum. The present synthesis was performed via ultraviolet light irradiation on a K2PtCl4 aqueous solution at ambient condition. The final pore sizes were in the range of 1-3nm. The walls of the pores were formed with platinum nanoparticles of 3-5nm average diameters...
October 5, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27729565/changes-in-the-prevalence-and-correlates-of-menthol-cigarette-use-in-the-usa-2004-2014
#19
Andrea C Villanti, Paul D Mowery, Cristine D Delnevo, Raymond S Niaura, David B Abrams, Gary A Giovino
INTRODUCTION: National data from 2004 to 2010 showed that despite decreases in non-menthol cigarette use prevalence, menthol cigarette use prevalence remained constant in adolescents and adults and increased in young adults. The purpose of the current study was to extend these analyses through 2014. METHODS: We estimated the prevalence of menthol cigarette smoking in the USA during 2004-2014 using annual cross-sectional data on persons aged ≥12 years from the National Survey on Drug Use and Health...
October 11, 2016: Tobacco Control
https://www.readbyqxmd.com/read/27722047/composition-of-volatile-compounds-and-in-vitro-antimicrobial-activity-of-nine-mentha-spp
#20
Yun Ji Park, Thanislas Bastin Baskar, Sun Kyung Yeo, Mariadhas Valan Arasu, Naif Abdullah Al-Dhabi, Soon Sung Lim, Sang Un Park
BACKGROUND: Mentha plants containing over 25 species are aromatic perennial herbs. These species have been interested and widely used because of various clinical findings. Many volatile compounds facilitate environmental interactions such as protecting themselves from pathogens, parasites, and herbivores. Therefore, this study assessed comparison of volatile composition and antimicrobial activity from nine Mentha species. The composition of volatiles was investigated from the aerial parts of nine different Mentha species using gas chromatography-mass spectrometry (GC/MS)...
2016: SpringerPlus
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