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Menthol

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https://www.readbyqxmd.com/read/28812893/%C3%AE-sulfinyl-benzoates-as-precursors-to-li-and-mg-carbenoids-for-the-stereoselective-iterative-homologation-of-boronic-esters
#1
Giorgia Casoni, Murat Kucukdisli, James M Fordham, Matthew Burns, Eddie L Myers, Varinder K Aggarwal
The stereoselective reagent-controlled homologation of boronic esters is one of a small number of iteratable synthetic transformations that if automated could form the basis of a veritable molecule-making machine. Recently, α-stannyl triisopropylbenzoates and α-sulfinyl chlorides have emerged as useful building blocks for the iterative homologation of boronic esters. However, α-stannyl benzoates need to be prepared using stoichiometric amounts of the (+)- or (-)-enantiomer of the scarcely available and expensive diamine sparteine; also, these building blocks, together with the byproducts that are generated during homologation, are perceived as being toxic...
August 16, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28805147/a-comparison-of-transdermal-over-the-counter-lidocaine-3-6-menthol-1-25-rx-lidocaine-5-and-placebo-for-back-pain-and-arthritis
#2
Eric Castro, David Dent
AIM: Transdermal lidocaine therapy has become a gold standard as part of a treatment regimen for patients who suffer from localized pain. We compared transdermal patches: over-the-counter (OTC) lidocaine 3.6% combined with menthol 1.25%, prescription lidocaine 5% (Rx) and placebo. METHODS: In a double-blind, placebo-controlled trial, 87 patients were randomized to: OTC, Rx or placebo. RESULTS: OTC met primary end points of noninferiority compared with Rx for efficacy, side effects and quality of life...
August 14, 2017: Pain Management
https://www.readbyqxmd.com/read/28800227/allelochemicals-vertical-leaching-affecting-their-bioactivity-and-microbial-community-of-soil
#3
Zhongxiang Xiao, Zhenghao Xu, Zhefeng Gu, Junfei Lv, Imran Haider Shamsi
Leaching of allelochemicals in soil is one of the fundamental processes that determine the allelopathic activities, but is often overlooked. In the present study, the vertical leaching of seven putative allelochemicals, as well as one pesticide and one herbicide, was investigated by using polyvinyl chloride columns combined with bioassay approach. The results indicated that the leachability of pretilachlor and imidacloprid were the best (Lƒ>0.8), followed by vanillin and coumarin (Lƒ>0.6). The leachability of daidzein, menthol and m-tyrosine were medium (0...
August 11, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28799699/a-comparative-study-on-the-therapeutic-effect-of-trpv1-trpa1-and-trpm8-agonists-on-swallowing-dysfunction-associated-with-aging-and-neurological-diseases
#4
D Alvarez-Berdugo, L Rofes, V Arreola, A Martin, L Molina, P Clavé
BACKGROUND: Oropharyngeal sensory impairment is a potential target to treat swallowing dysfunction in patients with oropharyngeal dysphagia (OD). AIM: To assess the therapeutic effect of stimulating oropharyngeal sensory afferents with TRPV1, TRPA1, or TRPM8 agonists vs increasing bolus viscosity in older and neurologic patients with OD by comparing four studies of similar experimental design. METHODS: Swallow function of 142 older patients with impaired safety of swallow at nectar ([50-350] mPa·s) viscosity was evaluated with videofluoroscopy (VFS) while treated with TRPV1 (150 μmol/L), TRPV1/A1 (150 μmol/L and 1 mmol/L), or TRPM8 (1 mmol/L or 10 mmol/L) agonists or modified starch (MS) at spoon thick viscosity (>1750 mPa·s)...
August 11, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28795021/african-peppermint-mentha-piperita-from-morocco-chemical-composition-and-antimicrobial-properties-of-essential-oil
#5
Chraibi Marwa, Kawtar Fikri-Benbrahim, Douae Ou-Yahia, Abdellah Farah
To replace and avoid synthetic chemicals toxicity, there is a growing interest in the investigation of natural products from plant origin for the discovery of active compounds with antimicrobial properties. This work was devoted to determine chemical composition and antimicrobial properties of the EO of M. piperita harvested in the garden of the National Institute of Medicinal and Aromatic Plants of Morocco. Experiments have been conducted at the Microbial Biotechnology Laboratory at the Sciences and Technology Faculty, Sidi Mohamed Ben Abdellah University, Fez, Morocco...
July 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/28769802/cellular-and-molecular-targets-of-menthol-actions
#6
REVIEW
Murat Oz, Eslam G El Nebrisi, Keun-Hang S Yang, Frank C Howarth, Lina T Al Kury
Menthol belongs to monoterpene class of a structurally diverse group of phytochemicals found in plant-derived essential oils. Menthol is widely used in pharmaceuticals, confectionary, oral hygiene products, pesticides, cosmetics, and as a flavoring agent. In addition, menthol is known to have antioxidant, anti-inflammatory, and analgesic effects. Recently, there has been renewed awareness in comprehending the biological and pharmacological effects of menthol. TRP channels have been demonstrated to mediate the cooling actions of menthol...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28768647/activation-of-transient-receptor-potential-melastatin-subtype-8-attenuates-cold-induced-hypertension-through-ameliorating-vascular-mitochondrial-dysfunction
#7
Shiqiang Xiong, Bin Wang, Shaoyang Lin, Hexuan Zhang, Yingsha Li, Xing Wei, Yuanting Cui, Xiao Wei, Zongshi Lu, Peng Gao, Li Li, Zhigang Zhao, Daoyan Liu, Zhiming Zhu
BACKGROUND: Environmental cold-induced hypertension is common, but how to treat cold-induced hypertension remains an obstacle. Transient receptor potential melastatin subtype 8 (TRPM8) is a mild cold-sensing nonselective cation channel that is activated by menthol. Little is known about the effect of TRPM8 activation by menthol on mitochondrial Ca(2+) homeostasis and the vascular function in cold-induced hypertension. METHODS AND RESULTS: Primary vascular smooth muscle cells from wild-type or Trpm8(-/-) mice were cultured...
August 2, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28767579/the-identification-of-the-trpm8-channel-on-primary-culture-of-human-nasal-epithelial-cells-and-its-response-to-cooling
#8
Shao-Cheng Liu, Hsuan-Hsuan Lu, Hueng-Chuen Fan, Hsing-Won Wang, Hang-Kang Chen, Fei-Peng Lee, Chong-Jen Yu, Yueng-Hsiang Chu
BACKGROUND: It has been proposed that the transient receptor potential (TRP) channel Melastatin 8 (TRPM8) is a cold-sensing TRP channel. However, its presence and its role in the nasal cavity have not yet been fully studied. METHODS: Immunohistology was used to study TRPM8 receptors in both the nasal mucosa tissue and the primary cultures of human nasal cells. Cells from primary cultures were immunostained with antibodies to TRPM8, mucin, cytokeratin (CK)-14, CK-18, and vimentin...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28766746/sensory-effects-of-transient-receptor-potential-channel-agonists-on-whole-mouth-saliva-extensional-rheology
#9
Jack William Houghton, Joachim Hans, Manuel Pesaro, Jakob Peter Ley, Guy Howard Carpenter, Gordon Proctor
The extensional rheology (ER) of saliva is a property associated with its ability to coat surfaces and is important for the maintenance of a normal mouth feeling. Transient receptor potential (TRP) channels are expressed in the oral cavity and this study investigated how the sensory effects of TRP channel agonists modify the ER of saliva. Healthy volunteers rinsed with solutions containing a TRP agonist. Unstimulated whole mouth saliva (WMS) was collected prior to rinsing and WMS was collected during the first and second minutes after the mouth rinse...
August 2017: Journal of Texture Studies
https://www.readbyqxmd.com/read/28761828/formulation-of-menthol-loaded-nanostructured-lipid-carriers-to-enhance-its-antimicrobial-activity-for-food-preservation
#10
Parizad Piran, Hossein Samadi Kafil, Saeed Ghanbarzadeh, Rezvan Safdari, Hamed Hamishehkar
Purpose: Due to the antimicrobial property, menthol have significant potential for food preservation and foodstuff shelf life improvement. Nevertheless, menthol instability, insolubility, and rapid crystallization in aqueous media make it unsuitable for used in food products. This work was aimed to prepare menthol-loaded nanostructured lipid carriers (NLCs) to enhance its antimicrobial activity. Methods: Morphology, particle size and size distribution, encapsulation efficiency percent (EE%), and physical stability of the optimized formulation, prepared by hot melt homogenization method, were characterized by scanning electron microscopy, particle size analyzing, gas chromatography, and X-ray diffraction (XRD) methods...
June 2017: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28760390/nicotine-pharmacokinetic-profiles-of-the-tobacco-heating-system-2-2-cigarettes-and-nicotine-gum-in-japanese-smokers
#11
Patrick Brossard, Rolf Weitkunat, Valerie Poux, Nicola Lama, Christelle Haziza, Patrick Picavet, Gizelle Baker, Frank Lüdicke
Two open-label randomized cross-over studies in Japanese smokers investigated the single-use nicotine pharmacokinetic profile of the Tobacco Heating System (THS) 2.2, cigarettes (CC) and nicotine replacement therapy (Gum). In each study, one on the regular and one on the menthol variants of the THS and CC, both using Gum as reference, 62 subjects were randomized to four sequences: Sequence 1: THS - CC (n = 22); Sequence 2: CC - THS (n = 22); Sequence 3: THS - Gum (n = 9); Sequence 4: Gum - THS (n = 9)...
July 29, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28747086/menthol-enhances-nicotine-induced-locomotor-sensitization-and-in-vivo-functional-connectivity-in-adolescence
#12
Matthew F Thompson, Guillaume L Poirier, Martha I Dávila-García, Wei Huang, Kelly Tam, Maxwell Robidoux, Michelle L Dubuke, Scott A Shaffer, Luis Colon-Perez, Marcelo Febo, Joseph R DiFranza, Jean A King
Mentholated cigarettes capture a quarter of the US market, and are disproportionately smoked by adolescents. Menthol allosterically modulates nicotinic acetylcholine receptor function, but its effects on the brain and nicotine addiction are unclear. To determine if menthol is psychoactive, we assessed locomotor sensitization and brain functional connectivity. Adolescent male Sprague Dawley rats were administered nicotine (0.4 mg/kg) daily with or without menthol (0.05 mg/kg or 5.38 mg/kg) for nine days. Following each injection, distance traveled in an open field was recorded...
July 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28743602/menthol-disrupts-nicotine-s-psychostimulant-properties-in-an-age-and-sex-dependent-manner-in-c57bl-6j-mice
#13
Benjamin W Fait, David C Thompson, Tenna N Mose, Peter Jatlow, Sven E Jordt, Marina R Picciotto, Yann S Mineur
Menthol is a commonly used flavorant in tobacco and e-cigarettes, and could contribute to nicotine sensitivity. To understand how menthol could contribute to nicotine intake and addiction, it is important to determine whether specific mechanisms related to sex and age could underlie behavioral changes induced by menthol-laced nicotinic products. Using a validated paradigm of nicotine-dependent locomotor stimulation, adolescent and adult C57BL/6J mice of both sexes were exposed to nicotine, or nicotine laced with menthol, as their sole source of fluid, and psychostimulant effects were evaluated by recording home cage locomotor activity for ten days...
July 22, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28740604/identification-of-a-novel-trpm8-agonist-from-nutmeg-a-promising-cooling-compound
#14
Tomohiro Shirai, Kentaro Kumihashi, Mitsuyoshi Sakasai, Hiroshi Kusuoku, Yusuke Shibuya, Atsushi Ohuchi
The transient receptor potential melastatin 8 (TRPM8) ion channel is the primary receptor for innocuous cold stimuli (<28 °C) in humans. TRPM8 agonists such as l-(-)-menthol are widely used as flavors and additives to impart briskness, in addition to medicinal uses for inflammation and pain. Though various natural and synthetic agonists have been explored, only few natural compounds are known. We report herein the identification and characterization of the novel neolignan agonist erythro- and threo-Δ(8')-7-ethoxy-4-hydroxy-3,3',5'-trimethoxy-8-O-4'-neolignan (1) with an EC50 of 0...
July 13, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28739522/bimodal-odor-processing-with-a-trigeminal-component-at-sub-and-suprathreshold-levels
#15
Robert Pellegrino, Edda Drechsler, Cornelia Hummel, Johnathan Warr, Thomas Hummel
Odors are typically bimodal in nature, interacting with the olfactory and trigeminal systems. The trigeminal component may be noticed (e.g. menthol) or perceptually ignored, leading to different neural substrates being recruited during odor encoding. Therefore, the current study was designed to explore the perceptual and central-nervous activations in response to pleasant bimodal odors using functional magnetic resonance imaging (fMRI). In this study, healthy subjects were exposed to odorants alone (unimodal) or with a "cooling" trigeminal component (bimodal) at sub- and suprathreshold concentrations with a portable olfactometer in a 3 T fMRI scanner...
July 21, 2017: Neuroscience
https://www.readbyqxmd.com/read/28712737/pharmacists-can-help-prevent-lipoid-pneumonia
#16
Ann E Cabri, Afoma King, Lee Morrow, Mark A Malesker
OBJECTIVES: To report 2 cases of lipoid pneumonia. SUMMARY: Lipoid pneumonia is an inflammatory process in the lower airways due to the presence of lipid molecules in the alveoli. Exogenous lipoid pneumonia is due to the inhalation or aspiration of fat-containing substances. Historically, mineral oil is the most common medication cause but there have also been several reports of lipoid pneumonia associated with petroleum jelly, medicated vapor rub, and lip glosses...
July 14, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28701045/investigating-chemical-composition-and-indications-of-hydrosol-soft-drinks-aromatic-waters-used-in-persian-folk-medicine-for-women-s-hormonal-and-reproductive-health-conditions
#17
Azadeh Hamedi, Mehdi Afifi, Hamed Etemadfard
Hydrosol soft drinks in Persian nutrition culture are produced as side products of the essential oil industry to be used as safe remedies for treatment of some ailments. This study investigated hydrosols for women's hormonal health conditions. Detailed information was gathered by questionnaires. Chemical constituents of these mono- or poly-herbal hydrosols were identified after liquid/liquid extraction and gas chromatography-mass spectrometry. Hierarchical cluster and K-means analysis (SPSS software) were used to find their relevance...
January 1, 2017: Journal of Evidence-based Complementary & Alternative Medicine
https://www.readbyqxmd.com/read/28667094/menthol-levels-in-cigarettes-from-eight-manufacturers
#18
Jiu Ai, Kenneth M Taylor, Joseph G Lisko, Hang Tran, Clifford H Watson, Matthew R Holman
No abstract text is available yet for this article.
June 30, 2017: Tobacco Control
https://www.readbyqxmd.com/read/28663522/it-s-the-21st-century-isn-t-it-past-time-to-ban-menthol-cigarette-sales
#19
EDITORIAL
Ruth E Malone
No abstract text is available yet for this article.
July 2017: Tobacco Control
https://www.readbyqxmd.com/read/28661301/finished-with-menthol-an-evidence-based-policy-option-that-will-save-lives
#20
Joelle M Lester, Stacey Younger Gagosian
Smoking remains the leading cause of preventable disease and death in the United States, killing approximately 480,000 people each year. This crushing health burden falls disproportionately, and recent CDC data shows that large disparities in adult cigarette smoking remain. One factor in these disparities is the use of flavors. Menthol cigarettes and other flavored tobacco products are used at higher rates by vulnerable populations including youth and young adults, African Americans, women, Hispanics and Asian Americans...
March 2017: Journal of Law, Medicine & Ethics: a Journal of the American Society of Law, Medicine & Ethics
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