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Menthol

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https://www.readbyqxmd.com/read/28431915/synergistic-anticandidal-activity-of-menthol-in-combination-with-itraconazole-and-nystatin-against-clinical-candida-glabrata-and-candida-krusei-isolates
#1
Aghil Sharifzadeh, Ali Reza Khosravi, Hojjatollah Shokri, Paria Samadi Tari
BACKGROUND: Candida glabrata (C. glabrata) and C. krusei are now emerging as serious hospital acquired infections in immunocompromised patients. Menthol, a terpenic compound, has been reported to have antifungal activity. OBJECTIVES: The aim of this study was to investigate the effect of menthol in combination with itraconazole or nystatin against C. glabrata and C. krusei isolates. METHODS: The effects of menthol along with itraconazole and nystatin, were evaluated by the Clinical Laboratory Standards Institute (CLSI) M44-A and CLSI M27-A3 methods...
April 18, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28426156/natural-terpene-derivatives-as-new-structural-task-specific-ionic-liquids-to-enhance-the-enantiorecognition-of-acidic-enantiomers-on-teicoplanin-based-stationary-phase-by-high-performance-liquid-chromatography
#2
Jolanta Flieger, Joanna Feder-Kubis, Małgorzata Tatarczak-Michalewska, Anita Płazińska, Anna Madejska, Marta Swatko-Ossor
We present the specific cooperative effect of a semisynthetic glycopeptide antibiotic teicoplanin and chiral ionic liquids containing the (1R,2S,5R)-(-)-menthol moiety on the chiral recognition of enantiomers of mandelic acid, vanilmandelic acid and phenyllactic acid. Experiments were performed chromatographically on an Astec Chirobiotic T chiral stationary phase applying the mobile phase with the addition of the chiral ionic liquids. The stereoselective binding of enantiomers to teicoplanin in presence of new chiral ionic liquids were evaluated applying thermodynamic measurements and the docking simulations...
April 20, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28416581/trp-channels-in-brown-and-white-adipogenesis-from-human-progenitors-new-therapeutic-targets-and-the-caveats-associated-with-the-common-antibiotic-streptomycin
#3
Anna Goralczyk, Marc van Vijven, Mathilde Koch, Cedric Badowski, M Shabeer Yassin, Sue-Anne Toh, Asim Shabbir, Alfredo Franco-Obregón, Michael Raghunath
Transient receptor potential (TRP) channels are polymodal cell sensors responding to diverse stimuli and widely implicated in the developmental programs of numerous tissues. The evidence for an involvement of TRP family members in adipogenesis, however, is scant. We present the first comprehensive expression profile of all known 27 human TRP genes in mesenchymal progenitors cells during white or brown adipogenesis. Using positive trilineage differentiation as an exclusion criterion, TRP polycystic (P)3, and TPR melastatin (M)8 were found to be uniquely adipospecific...
April 17, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28401925/menthol-enhances-nicotine-reward-related-behavior-by-potentiating-nicotine-induced-changes-in-nachr-function-nachr-upregulation-and-da-neuron-excitability
#4
Brandon J Henderson, Teagan R Wall, Beverley M Henley, Charlene H Kim, Sheri McKinney, Henry A Lester
Understanding why the quit rate among smokers of menthol cigarettes is lower than non-menthol smokers requires identifying the neurons that are altered by nicotine, menthol, and acetylcholine. Dopaminergic (DA) neurons in the ventral tegmental area (VTA) mediate the positive reinforcing effects of nicotine. Using mouse models, we show that menthol enhances nicotine-induced changes in nicotinic acetylcholine receptors (nAChRs) expressed on midbrain DA neurons. Menthol plus nicotine upregulates nAChR number and function on midbrain DA neurons more than nicotine alone...
April 12, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28400490/flavour-chemicals-in-a-sample-of-non-cigarette-tobacco-products-without-explicit-flavour-names-sold-in-new-york-city-in-2015
#5
Shannon M Farley, Kevin Rj Schroth, Victoria Grimshaw, Wentai Luo, Julia L DeGagne, Peyton A Tierney, Kilsun Kim, James F Pankow
BACKGROUND: Youth who experiment with tobacco often start with flavoured products. In New York City (NYC), local law restricts sales of all tobacco products with 'characterising flavours' except for 'tobacco, menthol, mint and wintergreen'. Enforcement is based on packaging: explicit use of a flavour name (eg, 'strawberry') or image depicting a flavour (eg, a fruit) is presumptive evidence that a product is flavoured and therefore prohibited. However, a tobacco product may contain significant levels of added flavour chemicals even when the label does not explicitly use a flavour name...
April 11, 2017: Tobacco Control
https://www.readbyqxmd.com/read/28400197/cutaneous-penetration-enhancing-effect-of-menthol-calcium-involvement
#6
Amit Joshi, Abhay Joshi, Hiren Patel, Dovenia Ponnoth, Grazia Stagni
Menthol is a naturally occurring terpene used as a penetration enhancer in topical and transdermal formulations. Literature shows a growing interest on menthol's interactions with the Transient-Receptor-Potential (TRPM-8) calcium channel. A decrease in extracellular Ca(+2) due to the activation of TRPM-8 channels produces inhibition of E-cadherin expression that is responsible for cell-cell adhesion. Since calcium is present in the entire epidermis, the purpose of this study is to evaluate whether the aforementioned properties of menthol are also related to its penetration-enhancing-effects...
April 8, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28399279/the-botanical-monoterpenes-linalool-and-eugenol-flush-out-nymphs-of-triatoma-infestans-hemiptera-reduviidae
#7
A N Moretti, E A Seccacini, E N Zerba, D Canale, R A Alzogaray
Monoterpenes are the main components of essential oils. Some members of this chemical family present insecticidal activity. Triatoma infestans (Klug) is the main vector of Chagas disease in Argentina, Bolivia, Paraguay, and Perú. The objective of this work was to evaluate the effect of six monoterpenes (1,8-cineole, eugenol, linalool, menthol, α-terpineol, and thymol) on the locomotor and flushing out activity of T. infestans. A video tracking technique was used to evaluate the locomotor activity of nymphs exposed to different concentrations of these chemicals applied as films on filter paper...
March 29, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28396565/a-clinical-and-mechanistic-study-of-topical-borneol-induced-analgesia
#8
Shu Wang, Dan Zhang, Jinsheng Hu, Qi Jia, Wei Xu, Deyuan Su, Hualing Song, Zhichun Xu, Jianmin Cui, Ming Zhou, Jian Yang, Jianru Xiao
Bingpian is a time-honored herb in traditional Chinese medicine (TCM). It is an almost pure chemical with a chemical composition of (+)-borneol and has been historically used as a topical analgesic for millennia. However, the clinical efficacy of topical borneol lacks stringent evidence-based clinical studies and verifiable scientific mechanism. We examined the analgesic efficacy of topical borneol in a randomized, double-blind, placebo-controlled clinical study involving 122 patients with postoperative pain...
April 10, 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/28396281/the-neural-pathway-for-lacrimal-gland-tear-secretion-in-new-zealand-white-rabbits
#9
Jiaojiao Wang, Rongyi Zhou, Weiping Gao
OBJECTIVE: We investigated the neural pathway for tear secretion from the lacrimal gland of New Zealand White rabbits. METHODS: Nine healthy adult New Zealand White rabbits were randomly divided into three experimental groups, namely, an irritant-stimulated group, a non-stimulated group, and a saline-stimulated group. Sanitized dry cotton swabs with menthol were used to wipe both of the rabbits' eyelids in the irritant-stimulated group, and the non-stimulated group and saline- stimulated group were compared as controls...
April 7, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28378793/effects-of-a-warm-compress-containing-menthol-on-the-tear-film-in-healthy-subjects-and-dry-eye-patients
#10
Reiko Arita, Naoyuki Morishige, Ichiro Sakamoto, Natsuko Imai, Yuko Shimada, Michihito Igaki, Atsushi Suzuki, Kouzo Itoh, Kazuo Tsubota
Menthol is thought to stimulate lacrimation via activation of cold-sensitive primary afferent neurons in the cornea. We evaluated a warm compress containing menthol as a potential treatment for dry eye by examining its effects on the tear film in healthy subjects (n = 20) and dry eye patients (n = 35). Disposable eyelid-warming steamers that either did (MH) or did not (HO) contain menthol were applied to one eye of each subject either once only for 10 min or repeatedly over 2 weeks. Single application of MH significantly increased tear meniscus volume (P = 8...
April 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28376975/smoking-behavior-and-exposure-results-of-a-menthol-cigarette-cross-over-study
#11
Christina Vaughan Watson, Patricia Richter, B Rey de Castro, Connie Sosnoff, Jennifer Potts, Pamela Clark, Joan McCraw, Xizheng Yan, David Chambers, Clifford Watson
OBJECTIVE: Our objective was to improve understanding of the differences in use behavior and exposure when smoking menthol and non-menthol cigarettes using a 2-part cross-over design. METHODS: Adult daily smokers were assigned randomly to alternate between 2 weeks of exclusively smoking a menthol test cigarette or a non-menthol test cigarette. Urine and saliva were collected for biomarker measurements; carbon monoxide (CO) was measured, and participants smoked test cigarettes through a CreSS® smoking topography device during 3 clinic visits...
May 1, 2017: American Journal of Health Behavior
https://www.readbyqxmd.com/read/28372230/residual-determination-of-anesthetic-menthol-in-fishes-by-sdme-gc-ms
#12
Bianca Mesquita Coelho Botrel, Daiane Cássia Pereira Abreu, Adelir Aparecida Saczk, Matheus Julien Ferreira Bazana, Sabrina Mesquita Coelho, Priscila Vieira E Rosa, Zuy Maria Magriotis, Rafael Machado Felix de Lima
The SDME-GC/MS method was applied to residual determination of anesthetic menthol in fish. The extractions took place from the headspace of the sample using 1.8µL of octane as the extraction solvent. To obtain the ideal extraction condition, was used Response Surface Methodology, defining: extraction time 15min, temperature 30°C and salt 3g. The method showed LOD and LOQ of 0.021 and 1.56µgL(-1) respectively, recovery of 94% and R(2) of 0.9997. The analyzes were performed on tilapia fillets anesthetized in five concentrations between 5 and 15×10(4)µgL(-1) and with times of slaughter after anesthesia of 0, 12, 24 and 48h...
August 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28367216/gc-method-validation-for-the-analysis-of-menthol-in-suppository-pharmaceutical-dosage-form
#13
Murad N Abualhasan, Abdel Naser Zaid, Nidal Jaradat, Ayman Mousa
Menthol is widely used as a fragrance and flavor in the food and cosmetic industries. It is also used in the medical and pharmaceutical fields for its various biological effects. Gas chromatography (GC) is considered to be a sensitive method for the analysis of menthol. GC chromatographic separation was developed using capillary column (VF-624) and a flame ionization detector (FID). The method was validated as per ICH guidelines for various parameters such as precision, linearity, accuracy, solution stability, robustness, limit of detection, and quantification...
2017: International Journal of Analytical Chemistry
https://www.readbyqxmd.com/read/28352213/prevalence-and-characteristics-of-flavoured-tobacco-use-among-students-in-grades-10-through-12-a-national-cross-sectional-study-in-canada-2012-2013
#14
Yelena Bird, Jennifer May, Chijioke Nwankwo, Razi Mahmood, John Moraros
BACKGROUND: Tobacco use is the leading cause of preventable death in Canada and the world. Despite documented decreases in the prevalence of smoking in Canada, increases in flavoured tobacco use by its youth poses a serious public health concern. This study examined the prevalence and characteristics of flavoured tobacco use among a national sample of Canadian students in grades 10 through 12. METHODS: This study used a cross-sectional design on a nationally generalizable, school-based, Youth Smoking Survey (YSS), 2012-2013...
2017: Tobacco Induced Diseases
https://www.readbyqxmd.com/read/28345425/efficacy-and-safety-of-topical-diclofenac-menthol-gel-for-ankle-sprain-a-randomized-double-blind-placebo-and-active-controlled-trial
#15
Pamela M Lai, Agron Collaku, Kenneth Reed
Purpose This study was performed to evaluate topical 1% diclofenac/3% menthol gel in treating ankle sprain. Design In this randomized, double-blind, placebo-controlled trial, adolescents and adults with acute ankle sprain (N = 385) applied 4 g of gel containing 1% diclofenac/3% menthol (n = 117), 1% diclofenac (n = 112), 3% menthol (n = 77), or placebo (n = 75) four times daily. The primary outcome was the area under the curve of pain intensity (PI) on movement [0 (no pain) to 10 (extreme pain)] from 24 to 72 hours post-application (AUC1-3 days)...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28342017/primary-localized-cutaneous-amyloidosis-a-systematic-treatment-review
#16
REVIEW
Till Weidner, Tanja Illing, Peter Elsner
BACKGROUND: Primary localized cutaneous amyloidosis (PLCA) is characterized by extracellular deposition of heterogenic amyloid proteins in the skin without systemic involvement. Lichen amyloidosis, macular amyloidosis, and (primary localized cutaneous) nodular amyloidosis are different subtypes of PLCA. OBJECTIVE: The aim of this study was to review the current reported treatment options for PLCA. METHODS: This systematic review was based on a search in the PubMed database for English and German articles from 1985 to 2016...
March 24, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28339669/in-their-own-words-young-adults-menthol-cigarette-initiation-perceptions-experiences-and-regulation-perspectives
#17
Olivia A Wackowski, Kiameesha R Evans, Melissa B Harrell, Alexandra Loukas, M Jane Lewis, Cristine D Delnevo, Cheryl L Perry
Background: Menthol cigarettes are disproportionately used by young people and have been called smoking starter products. However, limited qualitative research exists on young adults' perceptions of and experiences with these products, with much of it based on document reviews of the tobacco industry's research. Methods: We conducted six focus groups with young adult (ages 18-24) menthol smokers in New Jersey (half with black smokers) between December 2014 and March 2015...
February 17, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28334512/flow-pickering-emulsion-interfaces-enhance-catalysis-efficiency-and-selectivity-for-cyclization-of-citronellal
#18
Huan Chen, Houbing Zou, Yajuan Hao, Hengquan Yang
Cyclization of citronellal is a necessary intermediate step to produce the important flavor chemical (-)-menthol. Here, a continuous-flow Pickering emulsion (FPE) strategy for selective cyclization of citronellal to (-)-isopulegol by using water droplets hosting a heteropolyacid (HPA) catalyst to fill a column reactor is demonstrated. Owing to the large liquid-liquid interface and the excellent confinement ability of droplets toward HPA, the FPE system exhibited a much higher catalysis efficiency than its batch counterpart (2-5-fold) and an excellent durability (two months)...
March 23, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28334238/separate-and-combined-effects-of-mentha-piperata-and-mentha-pulegium-essential-oils-and-a-pathogenic-fungus-lecanicillium-muscarium-against-aphis-gossypii-hemiptera-aphididae
#19
Asgar Ebadollahi, Mahdi Davari, Jabrael Razmjou, Bahram Naseri
In the present study, the toxicity of essential oils of Mentha piperata L. and Mentha pulegium L. and pathogenicity of Lecanicillium muscarium (Zare & Gams) were studied in the melon aphid, Aphis gossypii Glover. Analyses of the essential oils by GC-MS indicated limonene (27.28%), menthol (24.71%), menthone (14.01%), and carvol (8.46%) in the M. piperata essential oil and pulegone (73.44%), piperitenone (5.49%), decane (4.99%), and limonene (3.07%) in the essential oil of M. pulegium as the main components...
March 3, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28333107/perceptions-and-experiences-with-flavored-non-menthol-tobacco-products-a-systematic-review-of-qualitative-studies
#20
REVIEW
Sarah D Kowitt, Clare Meernik, Hannah M Baker, Amira Osman, Li-Ling Huang, Adam O Goldstein
Although a few countries have banned flavored cigarettes (except menthol), flavors in most tobacco products remain unregulated across the globe. We conducted a systematic review of qualitative studies examining perceptions of and experiences with flavored non-menthol tobacco products. Of 20 studies on flavored tobacco products included in our qualitative systematic review, 10 examined hookah, six examined e-cigarettes, two examined little cigars and cigarillos (LCCs), and three examined other tobacco products, including cigarettes...
March 23, 2017: International Journal of Environmental Research and Public Health
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