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inositol hexaphosphate

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https://www.readbyqxmd.com/read/27725832/insulin-sensitizers-polycystic-ovary-syndrome-and-gynaecological-cancer-risk
#1
REVIEW
Rosa Lauretta, Giulia Lanzolla, Patrizia Vici, Luciano Mariani, Costanzo Moretti, Marialuisa Appetecchia
Preclinical, early phase clinical trials and epidemiological evidence support the potential role of insulin-sensitizers in cancer prevention and treatment. Insulin-sensitizers improve the metabolic and hormonal profile in PCOS patients and may also act as anticancer agents, especially in cancers associated with hyperinsulinemia and oestrogen dependent cancers. Several lines of evidence support the protection against cancer exerted by dietary inositol, in particular inositol hexaphosphate. Metformin, thiazolidinediones, and myoinositol postreceptor signaling may exhibit direct inhibitory effects on cancer cell growth...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27383681/isolation-of-inositol-hexaphosphate-ihp-degrading-bacteria-from-arbuscular-mycorrhizal-fungal-hyphal-compartments-using-a-modified-baiting-method-involving-alginate-beads-containing-ihp
#2
Shintaro Hara, Masanori Saito
Phytate (inositol hexaphosphate; IHP)-degrading microbes have been suggested to contribute to arbuscular mycorrhizal fungi (AMF)-mediated P transfer from IHP to plants; however, no IHP degrader involved in AMF-mediated P transfer has been isolated to date. We herein report the isolation of IHP-degrading bacteria using a modified baiting method. We applied alginate beads as carriers of IHP powder, and used them as recoverable IHP in the AM fungal compartment of plant cultivation experiments. P transfer from IHP in alginate beads via AMF was confirmed, and extracted DNA from alginate beads was analyzed by denaturing gradient gel electrophoresis targeting the 16S rRNA gene and a clone library method for the beta-propeller phytase (BPP) gene...
September 29, 2016: Microbes and Environments
https://www.readbyqxmd.com/read/27257055/synergy-and-antagonism-in-regulation-of-recombinant-human-ino80-chromatin-remodeling-complex
#3
Oliver Willhoft, Rohan Bythell-Douglas, Elizabeth A McCormack, Dale B Wigley
We have purified a minimal core human Ino80 complex from recombinant protein expressed in insect cells. The complex comprises one subunit each of an N-terminally truncated Ino80, actin, Arp4, Arp5, Arp8, Ies2 and Ies6, together with a single heterohexamer of the Tip49a and Tip49b proteins. This core complex has nucleosome sliding activity that is similar to that of endogenous human and yeast Ino80 complexes and is also inhibited by inositol hexaphosphate (IP6). We show that IP6 is a non-competitive inhibitor that acts by blocking the stimulatory effect of nucleosomes on the ATPase activity...
September 30, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27187454/inositol-hexaphosphate-and-inositol-inhibit-colorectal-cancer-metastasis-to-the-liver-in-balb-c-mice
#4
Min Fu, Yang Song, Zhaoxia Wen, Xingyi Lu, Lianhua Cui
Inositol hexaphosphate (IP6) and inositol (Ins), naturally occurring carbohydrates present in most mammals and plants, inhibit the growth of numerous cancers both in vitro and in vivo. In this study, we first examined the anti-metastatic effects of IP6 and Ins using a liver metastasis model of colorectal cancer (CRC) in BALB/c mice. CT-26 cells were injected into the splenic capsule of 48 BALB/c mice. The mice were then randomly divided into four groups: IP6, Ins, IP6 + Ins and normal saline control (n = 12 per group)...
2016: Nutrients
https://www.readbyqxmd.com/read/27124810/the-effect-of-inositol-hexaphosphate-on-cadmium-sorption-to-gibbsite
#5
Maika Ruyter-Hooley, Anna-Carin Larsson, Bruce B Johnson, Oleg N Antzutkin, Michael J Angove
HYPOTHESIS: Oxides, hydrous oxides and hydroxides of aluminium and iron are important in determining the availability of trace and heavy metals in soil systems. The presence of complexing anions is also known to affect the binding of these metals in soils. Since organophosphates, such as inositol hexaphosphate (IP6), are present in most soil systems they are expected to affect the nature of the interaction between metal ions and metal (hyr)oxides. EXPERIMENTS: Both adsorption edge and isotherm experiments were conducted on Cd(II)-gibbsite and Cd(II)-IP6-gibbsite systems...
July 15, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27109927/insights-into-the-activation-mechanism-of-class-i-hdac-complexes-by-inositol-phosphates
#6
Peter J Watson, Christopher J Millard, Andrew M Riley, Naomi S Robertson, Lyndsey C Wright, Himali Y Godage, Shaun M Cowley, Andrew G Jamieson, Barry V L Potter, John W R Schwabe
Histone deacetylases (HDACs) 1, 2 and 3 form the catalytic subunit of several large transcriptional repression complexes. Unexpectedly, the enzymatic activity of HDACs in these complexes has been shown to be regulated by inositol phosphates, which bind in a pocket sandwiched between the HDAC and co-repressor proteins. However, the actual mechanism of activation remains poorly understood. Here we have elucidated the stereochemical requirements for binding and activation by inositol phosphates, demonstrating that activation requires three adjacent phosphate groups and that other positions on the inositol ring can tolerate bulky substituents...
2016: Nature Communications
https://www.readbyqxmd.com/read/27088315/direct-covalent-grafting-of-phytate-to-titanium-surfaces-through-ti-o-p-bonding-shows-bone-stimulating-surface-properties-and-decreased-bacterial-adhesion
#7
Alba Córdoba, Margarita Hierro-Oliva, Miguel Ángel Pacha-Olivenza, María Coronada Fernández-Calderón, Joan Perelló, Bernat Isern, María Luisa González-Martín, Marta Monjo, Joana M Ramis
Myo-inositol hexaphosphate, also called phytic acid or phytate (IP6), is a natural molecule abundant in vegetable seeds and legumes. Among other functions, IP6 inhibits bone resorption. It is adsorbed on the surface of hydroxyapatite, inhibiting its dissolution and decreasing the progressive loss of bone mass. We present here a method to directly functionalize Ti surfaces covalently with IP6, without using a cross-linker molecule, through the reaction of the phosphate groups of IP6 with the TiO2 layer of Ti substrates...
May 11, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/26984477/a-novel-hydroxyapatite-film-coated-with-ionic-silver-via-inositol-hexaphosphate-chelation-prevents-implant-associated-infection
#8
Haruki Funao, Shigenori Nagai, Aya Sasaki, Tomoyuki Hoshikawa, Takashi Tsuji, Yasunori Okada, Shigeo Koyasu, Yoshiaki Toyama, Masaya Nakamura, Mamoru Aizawa, Morio Matsumoto, Ken Ishii
Various silver-coated implants have been developed to prevent implant-associated infections, and have shown dramatic effects in vitro. However, the in vivo results have been inconsistent. Recent in vitro studies showed that silver exerts antibacterial activity by mediating the generation of reactive oxygen species in the presence of oxygen. To maintain its antibacterial activity in vivo, the silver should remain in an ionic state and be stably bound to the implant surface. Here, we developed a novel bacteria-resistant hydroxyapatite film in which ionic silver is immobilized via inositol hexaphosphate chelation using a low-heat immersion process...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26975775/protective-effect-of-myo-inositol-hexaphosphate-phytate-on-abdominal-aortic-calcification-in-patients-with-chronic-kidney-disease
#9
Pilar Sanchis, Juan Manuel Buades, Francisco Berga, Miguel Mas Gelabert, Marilisa Molina, María Victoria Íñigo, Susana García, Jorge Gonzalez, Maria Rosario Bernabeu, Antonia Costa-Bauzá, Felix Grases
OBJECTIVE: The aim of this study was to evaluate the relationship between physiological levels of myo-inositol hexaphosphate (phytate) and cardiovascular (CV) calcification in patients with chronic kidney disease (CKD). DESIGN AND METHODS: This was a prospective cross-sectional study conducted from December 2012 to June 2013. SUBJECTS: Sixty-nine consecutive patients with CKD who were not undergoing renal replacement therapy. INTERVENTION: All subjects were given lateral lumbar X-rays to quantify abdominal aortic calcification (AAC)...
July 2016: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/26647627/down-regulation-of-inducible-nitric-oxide-synthase-expression-by-inositol-hexaphosphate-in-human-colon-cancer-cells
#10
Małgorzata Kapral, Joanna Wawszczyk, Stanisław Sośnicki, Ludmiła Węglarz
Inflammatory bowel disease (IBD) is chronic inflammatory condition associated with increased risk of developing colorectal cancer. A number of mediators of inflammation, such as pro-inflammatory cytokines, prostaglandins and nitric oxide have been involved in carcinogenesis, especially in the promotion and progression stages. NO is synthesized from L-arginine by constitutively expressed endothelial and neuronal nitric oxide synthases (eNOS and nNOS, respectively) and an inducible NOS (iNOS) isoform expressed under inflammatory conditions...
July 2015: Acta Poloniae Pharmaceutica
https://www.readbyqxmd.com/read/26581571/conundrum-of-ip6
#11
COMMENT
Ivana Vucenik
Here are comments on the recent paper on the determination of inositol hexaphosphate (IP6) in human plasma and on its efficacy.
November 2015: Open Biology
https://www.readbyqxmd.com/read/26335902/cytotoxic-effect-of-inositol-hexaphosphate-and-its-ni-ii-complex-on-human-acute-leukemia-jurkat-t-cells
#12
Eliane May de Lima, Carla Cristine Kanunfre, Lucas Ferrari de Andrade, Daniel Granato, Neiva Deliberali Rosso
Inositol hexaphosphate (InsP6) is present in cereals, legumes, nuts and seed oils and is biologically active against some tumor and cancer cells. Herein, this study aimed at evaluating the cellular toxicity, antiproliferative activity and effects on cell cycle progression of free InsP6 and InsP6-Ni(II) of leukemic T (Jurkat) and normal human cells. Treatments with InsP6 at concentrations between 1.0 and 4.0mM significantly decreased the viability of Jurkat cells, but showed no cytotoxic effect on normal human lymphocytes...
December 2015: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/26221783/novel-fiber-rich-lentil-flours-as-snack-type-functional-foods-an-extrusion-cooking-effect-on-bioactive-compounds
#13
P Morales, J De J Berrios, A Varela, C Burbano, C Cuadrado, M Muzquiz, M M Pedrosa
Novel snack-type functional foods based on extruded lentil flours could convey the related health benefit of their bioactive compounds, provide a gluten-free alternative to consumers, and potentially increase the consumption of pulses. Extrusion treatment promoted an increase in galactopinitol, ciceritol, raffinose, stachyose and total α-galactoside content, in most lentil flours. As α-galactosides may act as prebiotics, they could convey beneficial effects to human and monogastric animals. Conversely, extrusion significantly (p < 0...
September 2015: Food & Function
https://www.readbyqxmd.com/read/25973024/inositol-hexaphosphate-suppresses-growth-and-induces-apoptosis-in-ht-29-colorectal-cancer-cells-in-culture-pi3k-akt-pathway-as-a-potential-target
#14
Guiyuan Liu, Yang Song, Lianhua Cui, Zhaoxia Wen, Xiaoqing Lu
BACKGROUND: Inositol hexaphosphate (IP6) is a polyphosphorylated carbohydrate that is present in high amounts in almost all plants and mammalian cells. IP6 induces apoptosis in multiple types of cancer cells, including prostate cancer, breast cancer, skin tumor, liver cancer and colorectal cancer. However, little is known regarding the molecular mechanisms of its anticancer effects. Therefore, this study was conducted to investigate the activity of IP6 against human colorectal cancer cells (HT-29) and to determine whether the IP6 regulates apoptosis in HT-29 cells by inhibiting the PI3K/Akt signaling pathway...
2015: International Journal of Clinical and Experimental Pathology
https://www.readbyqxmd.com/read/25963718/phytase-activity-in-lichens
#15
Niall F Higgins, Peter D Crittenden
Phytase activity was investigated in 13 lichen species using a novel assay method. The work tested the hypothesis that phytase is a component of the suite of surface-bound lichen enzymes that hydrolyse simple organic forms of phosphorus (P) and nitrogen (N) deposited onto the thallus surface. Hydrolysis of inositol hexaphosphate (InsP6 , the substrate for phytase) and appearance of lower-order inositol phosphates (InsP5 -InsP1 ), the hydrolysis products, were measured by ion chromatography. Phytase activity in Evernia prunastri was compared among locations with contrasting rates of N deposition...
October 2015: New Phytologist
https://www.readbyqxmd.com/read/25745771/influence-of-inositol-hexaphosphate-on-the-expression-of-selected-proliferation-markers-in-il-1%C3%AE-stimulated-intestinal-epithelial-cells
#16
Małgorzata Kapral, Stanisław Sośnicki, Joanna Wawszczyk, Ludmiła Węglarz
The aim of the present study was to examine the influence of IP6, a naturally occurring phytochem- ical, on the expression of genes coding for proliferation markers, i.e., cyclin D1 (CCND1) and histone H3 in IL-1β-stimulated intestinal cancer cell line Caco-2. Quantification of genes expression was carried out using real time RT-QPCR technique in Caco-2 cells after treatment with IL-1β, 1 and 2.5 mM of IP6 for 3, 6 and 12 h. In separate cultures, cells were incubated with IL-1β for the indicated times. The untreated Caco-2 cells were used as the control...
November 2014: Acta Poloniae Pharmaceutica
https://www.readbyqxmd.com/read/25460716/surface-complexation-modeling-of-inositol-hexaphosphate-sorption-onto-gibbsite
#17
Maika Ruyter-Hooley, Anna-Carin Larsson, Bruce B Johnson, Oleg N Antzutkin, Michael J Angove
The sorption of Inositol hexaphosphate (IP6) onto gibbsite was investigated using a combination of adsorption experiments, (31)P solid-state MAS NMR spectroscopy, and surface complexation modeling. Adsorption experiments conducted at four temperatures showed that IP6 sorption decreased with increasing pH. At pH 6, IP6 sorption increased with increasing temperature, while at pH 10 sorption decreased as the temperature was raised. (31)P MAS NMR measurements at pH 3, 6, 9 and 11 produced spectra with broad resonance lines that could be de-convoluted with up to five resonances (+5, 0, -6, -13 and -21ppm)...
February 15, 2015: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/25444642/dietary-phytic-acid-modulates-characteristics-of-the-colonic-luminal-environment-and-reduces-serum-levels-of-proinflammatory-cytokines-in-rats-fed-a-high-fat-diet
#18
Yukako Okazaki, Tetsuyuki Katayama
Dietary phytic acid (PA; myo-inositol [MI] hexaphosphate) is known to inhibit colon carcinogenesis in rodents. Dietary fiber, which is a negative risk factor of colon cancer, improves characteristics of the colonic environment, such as the content of organic acids and microflora. We hypothesized that dietary PA would improve the colonic luminal environment in rats fed a high-fat diet. To test this hypothesis, rats were fed diets containing 30% beef tallow with 2.04% sodium PA, 0.4% MI, or 1.02% sodium PA + 0...
December 2014: Nutrition Research
https://www.readbyqxmd.com/read/25426546/investigation-of-soil-legacy-phosphorus-transformation-in-long-term-agricultural-fields-using-sequential-fractionation-p-k-edge-xanes-and-solution-p-nmr-spectroscopy
#19
Jin Liu, Yongfeng Hu, Jianjun Yang, Dalel Abdi, Barbara J Cade-Menun
Understanding legacy phosphorus (P) build-up and draw-down from long-term fertilization is essential for effective P management. Using replicated plots from Saskatchewan, Canada, with P fertilization from 1967 to 1995 followed by either P fertilization or P cessation (1995-2010), soil P was characterized in surface and subsurface layers using sequential fractionation, P K-edge X-ray absorption near-edge structure (XANES) and solution (31)P nuclear magnetic resonance (P NMR) spectroscopy. Legacy P from a 28-year build-up was sufficient for 15 years of wheat cultivation, resulting in no significant differences in crop yield in 2010...
January 6, 2015: Environmental Science & Technology
https://www.readbyqxmd.com/read/25372635/-inhibitory-effect-of-inositol-hexaphosphate-on-proliferation-of-lncap-cells-and-its-relation-to-igfbp-3-expression
#20
Hai-peng Zhu, Feng Yun, Tao Jiu
OBJECTIVE: To investigate the effect of inositol hexaphosphate (IP6) on proliferation of human prostate carcinoma LNCaP cells and its relation to insulin-like growth factors binding protein-3 (IGFBP-3) expression. METHODS: The siRNA technology was used to silence the IGFBP-3 gene in LNCaP cells. LNCaP cells and IGFBP-3 gene silenced LNCaP cells were exposed to IP6 for 24 h. Cell viability was measured by MTT assay; cell cycle arrest and cell apoptosis were detected by flow cytometry...
September 2014: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
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