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inositol hexaphosphate

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https://www.readbyqxmd.com/read/28805704/effects-of-adding-polysaccharides-and-citric-acid-into-sodium-dihydrogen-phosphate-mixing-solution-on-the-material-properties-of-gelatin-hybridized-calcium-phosphate-cement
#1
Keishi Kiminami, Toshiisa Konishi, Minori Mizumoto, Kohei Nagata, Michiyo Honda, Hidetoshi Arimura, Mamoru Aizawa
We have succeeded in improving the material properties of a chelate-setting calcium-phosphate cement (CPC), which is composed of hydroxyapatite (HAp) the surface of which has been modified with inositol hexaphosphate (IP6) by adding α-tricalcium phosphate (α-TCP) powder. In order to create a novel chelate-setting CPC with sufficient bioresorbability, gelatin particles were added into the IP6-HAp/α-TCP cement system to modify the material properties. The effects of adding polysaccharides (chitosan, chondroitin sulfate, and sodium alginate) into the sodium dihydrogen phosphate mixing solution on the material properties of the gelatin-hybridized CPC were evaluated...
August 12, 2017: Materials
https://www.readbyqxmd.com/read/28797636/modulating-effect-of-inositol-hexaphosphate-on-arachidonic-acid-dependent-pathways-in-colon-cancer-cells
#2
Małgorzata Kapral, Joanna Wawszczyk, Stanisław Sośnicki, Katarzyna Jesse, Ludmiła Węglarz
Cyclooxygenase (COX) and lipoxygenase (LOX) are key enzymes of arachidonic acid metabolism. Their products, prostaglandins and leukotrienes, are involved in the pathogenesis of inflammatory bowel diseases and colorectal cancer. The aim of the study was to examine the influence of inositol hexaphosphate (IP6), a naturally occurring phytochemical, on the expression of genes encoding COX and LOX isoforms and synthesis of their products (PGE2 and LTB4) in colon cancer cell line Caco-2 stimulated with pro-inflammatory agents (IL-1β/TNFα)...
August 8, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28737762/mechanism-of-host-substrate-acetylation-by-a-yopj-family-effector
#3
Zhi-Min Zhang, Ka-Wai Ma, Linfeng Gao, Zhenquan Hu, Simon Schwizer, Wenbo Ma, Jikui Song
The Yersinia outer protein J (YopJ) family of bacterial effectors depends on a novel acetyltransferase domain to acetylate signalling proteins from plant and animal hosts. However, the underlying mechanism is unclear. Here, we report the crystal structures of PopP2, a YopJ effector produced by the plant pathogen Ralstonia solanacearum, in complex with inositol hexaphosphate (InsP6), acetyl-coenzyme A (AcCoA) and/or substrate Resistance to Ralstonia solanacearum 1 (RRS1-R)WRKY. PopP2 recognizes the WRKYGQK motif of RRS1-RWRKY to position a targeted lysine in the active site for acetylation...
July 24, 2017: Nature Plants
https://www.readbyqxmd.com/read/28724186/inositol-hexaphosphate-insp6-as-an-effective-topical-treatment-for-patients-receiving-adjuvant-chemotherapy-after-breast-surgery
#4
S Proietti, V Pasta, A Cucina, C Aragona, E Palombi, I Vucenik, M Bizzarri
OBJECTIVE: Oral treatment with inositol hexaphosphate (InsP6) has shown to be efficient in decreasing adverse effects in patients with breast cancer under chemotherapy. This study was aimed at evaluating and comparing the efficacy of topical InsP6 in improving quality of life in women treated with anticancer drugs. PATIENTS AND METHODS: The study was a double-blind, randomized controlled trial (RCT) with allocation concealment of 20 patients in two groups, one (experimental) applied 4% topical formulation of InsP6 once a day, whereas the second one (control) a gel containing hyaluronic acid...
June 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28404949/metabolomics-uncovers-a-link-between-inositol-metabolism-and-osteosarcoma-metastasis
#5
Ling Ren, Ellen S Hong, Arnulfo Mendoza, Sameer Issaq, Christine Tran Hoang, Michael Lizardo, Amy LeBlanc, Chand Khanna
Cancer development and progression are characterized by complex molecular events. The acquisition of these events is primarily believed to result from alterations in gene and protein expression/function. Recent studies have also suggested the role of metabolic alterations, or "metabolic reprogramming," that may similarly contribute to these events. Indeed, our previous investigations in osteosarcoma (OS) identified metabolic changes uniquely linked to metastasis. Based on those findings, here we sought to build a more detailed understanding of the specific alterations in metabolites or metabolic pathways that may be responsible for the observed metastasis-associated metabolic alterations, suggested by gene expression data...
June 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28315345/inositol-hexaphosphate-suppresses-colorectal-cancer-cell-proliferation-via-the-akt-gsk-3%C3%AE-%C3%AE-catenin-signaling-cascade-in-a-1-2-dimethylhydrazine-induced-rat-model
#6
Wenyang Yu, Cuiping Liu, Xin Li, Fuguo Yang, Lixue Cheng, Chang Liu, Yang Song
Colorectal cancer (CRC) is common worldwide, and most treatments for CRC have undesirable side effects. Many researchers have demonstrated that inositol hexaphosphate (IP6) has potent anticarcinogenic activity against CRC and no apparent toxicity to normal cells. However, the underlying mechanism is still unclear. In this study, we investigated the anticancer and anti-proliferative properties of IP6 in CRC and its possible mechanisms during this chemopreventive process. We examined the expression of genes related to the PI3K/Akt and Wnt pathways at the transcriptional and translational levels in a DMH-induced rat CRC model following IP6 administration...
March 15, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28169546/colloidal-vesicular-system-of-inositol-hexaphosphate-to-counteract-dmba-induced-dysregulation-of-markers-pertaining-to-cellular-proliferation-differentiation-and-inflammation-of-epidermal-layer-in-mouse-model
#7
Malti Arya, Prakash Tiwari, Chandra Bhushan Tripathi, Poonam Parashar, Mahendra Singh, Priyam Sinha, Narayan P Yadav, Gaurav Kaithwas, Krishna P Gupta, Shubhini A Saraf
Cancer is a global health problem and chemoprevention is a promising approach for reducing cancer burden. Inositol hexaphosphate (IP6), a natural bioactive constituent of cereals, legumes, etc., has momentous potential as an antiangiogenic agent, that specifically affects malignant cells. The shortcoming is its quick absorption on oral/topical administration. Niosomes are flexible carriers for topical drug delivery. The central venture of current research was to optimize and characterize niosomal delivery system of IP6 for treatment of skin cancer...
February 16, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/27977887/modulation-of-hemoglobin-dynamics-by-an-allosteric-effector
#8
Jyotsana Lal, Marco Maccarini, Peter Fouquet, Nancy T Ho, Chien Ho, Lee Makowski
Hemoglobin (Hb) is an extensively studied paradigm of proteins that alter their function in response to allosteric effectors. Models of its action have been used as prototypes for structure-function relationships in many proteins, and models for the molecular basis of its function have been deeply studied and extensively argued. Recent reports suggest that dynamics may play an important role in its function. Relatively little is known about the slow, correlated motions of hemoglobin subunits in various structural states because experimental and computational strategies for their characterization are challenging...
March 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/27725832/insulin-sensitizers-polycystic-ovary-syndrome-and-gynaecological-cancer-risk
#9
REVIEW
Rosa Lauretta, Giulia Lanzolla, Patrizia Vici, Luciano Mariani, Costanzo Moretti, Marialuisa Appetecchia
Preclinical, early phase clinical trials and epidemiological evidence support the potential role of insulin-sensitizers in cancer prevention and treatment. Insulin-sensitizers improve the metabolic and hormonal profile in PCOS patients and may also act as anticancer agents, especially in cancers associated with hyperinsulinemia and oestrogen dependent cancers. Several lines of evidence support the protection against cancer exerted by dietary inositol, in particular inositol hexaphosphate. Metformin, thiazolidinediones, and myoinositol postreceptor signaling may exhibit direct inhibitory effects on cancer cell growth...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27383681/isolation-of-inositol-hexaphosphate-ihp-degrading-bacteria-from-arbuscular-mycorrhizal-fungal-hyphal-compartments-using-a-modified-baiting-method-involving-alginate-beads-containing-ihp
#10
Shintaro Hara, Masanori Saito
Phytate (inositol hexaphosphate; IHP)-degrading microbes have been suggested to contribute to arbuscular mycorrhizal fungi (AMF)-mediated P transfer from IHP to plants; however, no IHP degrader involved in AMF-mediated P transfer has been isolated to date. We herein report the isolation of IHP-degrading bacteria using a modified baiting method. We applied alginate beads as carriers of IHP powder, and used them as recoverable IHP in the AM fungal compartment of plant cultivation experiments. P transfer from IHP in alginate beads via AMF was confirmed, and extracted DNA from alginate beads was analyzed by denaturing gradient gel electrophoresis targeting the 16S rRNA gene and a clone library method for the beta-propeller phytase (BPP) gene...
September 29, 2016: Microbes and Environments
https://www.readbyqxmd.com/read/27257055/synergy-and-antagonism-in-regulation-of-recombinant-human-ino80-chromatin-remodeling-complex
#11
Oliver Willhoft, Rohan Bythell-Douglas, Elizabeth A McCormack, Dale B Wigley
We have purified a minimal core human Ino80 complex from recombinant protein expressed in insect cells. The complex comprises one subunit each of an N-terminally truncated Ino80, actin, Arp4, Arp5, Arp8, Ies2 and Ies6, together with a single heterohexamer of the Tip49a and Tip49b proteins. This core complex has nucleosome sliding activity that is similar to that of endogenous human and yeast Ino80 complexes and is also inhibited by inositol hexaphosphate (IP6). We show that IP6 is a non-competitive inhibitor that acts by blocking the stimulatory effect of nucleosomes on the ATPase activity...
September 30, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27187454/inositol-hexaphosphate-and-inositol-inhibit-colorectal-cancer-metastasis-to-the-liver-in-balb-c-mice
#12
Min Fu, Yang Song, Zhaoxia Wen, Xingyi Lu, Lianhua Cui
Inositol hexaphosphate (IP6) and inositol (Ins), naturally occurring carbohydrates present in most mammals and plants, inhibit the growth of numerous cancers both in vitro and in vivo. In this study, we first examined the anti-metastatic effects of IP6 and Ins using a liver metastasis model of colorectal cancer (CRC) in BALB/c mice. CT-26 cells were injected into the splenic capsule of 48 BALB/c mice. The mice were then randomly divided into four groups: IP6, Ins, IP6 + Ins and normal saline control (n = 12 per group)...
May 12, 2016: Nutrients
https://www.readbyqxmd.com/read/27124810/the-effect-of-inositol-hexaphosphate-on-cadmium-sorption-to-gibbsite
#13
Maika Ruyter-Hooley, Anna-Carin Larsson, Bruce B Johnson, Oleg N Antzutkin, Michael J Angove
HYPOTHESIS: Oxides, hydrous oxides and hydroxides of aluminium and iron are important in determining the availability of trace and heavy metals in soil systems. The presence of complexing anions is also known to affect the binding of these metals in soils. Since organophosphates, such as inositol hexaphosphate (IP6), are present in most soil systems they are expected to affect the nature of the interaction between metal ions and metal (hyr)oxides. EXPERIMENTS: Both adsorption edge and isotherm experiments were conducted on Cd(II)-gibbsite and Cd(II)-IP6-gibbsite systems...
July 15, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27109927/insights-into-the-activation-mechanism-of-class-i-hdac-complexes-by-inositol-phosphates
#14
Peter J Watson, Christopher J Millard, Andrew M Riley, Naomi S Robertson, Lyndsey C Wright, Himali Y Godage, Shaun M Cowley, Andrew G Jamieson, Barry V L Potter, John W R Schwabe
Histone deacetylases (HDACs) 1, 2 and 3 form the catalytic subunit of several large transcriptional repression complexes. Unexpectedly, the enzymatic activity of HDACs in these complexes has been shown to be regulated by inositol phosphates, which bind in a pocket sandwiched between the HDAC and co-repressor proteins. However, the actual mechanism of activation remains poorly understood. Here we have elucidated the stereochemical requirements for binding and activation by inositol phosphates, demonstrating that activation requires three adjacent phosphate groups and that other positions on the inositol ring can tolerate bulky substituents...
April 25, 2016: Nature Communications
https://www.readbyqxmd.com/read/27088315/direct-covalent-grafting-of-phytate-to-titanium-surfaces-through-ti-o-p-bonding-shows-bone-stimulating-surface-properties-and-decreased-bacterial-adhesion
#15
Alba Córdoba, Margarita Hierro-Oliva, Miguel Ángel Pacha-Olivenza, María Coronada Fernández-Calderón, Joan Perelló, Bernat Isern, María Luisa González-Martín, Marta Monjo, Joana M Ramis
Myo-inositol hexaphosphate, also called phytic acid or phytate (IP6), is a natural molecule abundant in vegetable seeds and legumes. Among other functions, IP6 inhibits bone resorption. It is adsorbed on the surface of hydroxyapatite, inhibiting its dissolution and decreasing the progressive loss of bone mass. We present here a method to directly functionalize Ti surfaces covalently with IP6, without using a cross-linker molecule, through the reaction of the phosphate groups of IP6 with the TiO2 layer of Ti substrates...
May 11, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/26984477/a-novel-hydroxyapatite-film-coated-with-ionic-silver-via-inositol-hexaphosphate-chelation-prevents-implant-associated-infection
#16
Haruki Funao, Shigenori Nagai, Aya Sasaki, Tomoyuki Hoshikawa, Takashi Tsuji, Yasunori Okada, Shigeo Koyasu, Yoshiaki Toyama, Masaya Nakamura, Mamoru Aizawa, Morio Matsumoto, Ken Ishii
Various silver-coated implants have been developed to prevent implant-associated infections, and have shown dramatic effects in vitro. However, the in vivo results have been inconsistent. Recent in vitro studies showed that silver exerts antibacterial activity by mediating the generation of reactive oxygen species in the presence of oxygen. To maintain its antibacterial activity in vivo, the silver should remain in an ionic state and be stably bound to the implant surface. Here, we developed a novel bacteria-resistant hydroxyapatite film in which ionic silver is immobilized via inositol hexaphosphate chelation using a low-heat immersion process...
March 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/26975775/protective-effect-of-myo-inositol-hexaphosphate-phytate-on-abdominal-aortic-calcification-in-patients-with-chronic-kidney-disease
#17
Pilar Sanchis, Juan Manuel Buades, Francisco Berga, Miguel Mas Gelabert, Marilisa Molina, María Victoria Íñigo, Susana García, Jorge Gonzalez, Maria Rosario Bernabeu, Antonia Costa-Bauzá, Felix Grases
OBJECTIVE: The aim of this study was to evaluate the relationship between physiological levels of myo-inositol hexaphosphate (phytate) and cardiovascular (CV) calcification in patients with chronic kidney disease (CKD). DESIGN AND METHODS: This was a prospective cross-sectional study conducted from December 2012 to June 2013. SUBJECTS: Sixty-nine consecutive patients with CKD who were not undergoing renal replacement therapy. INTERVENTION: All subjects were given lateral lumbar X-rays to quantify abdominal aortic calcification (AAC)...
July 2016: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/26647627/down-regulation-of-inducible-nitric-oxide-synthase-expression-by-inositol-hexaphosphate-in-human-colon-cancer-cells
#18
Małgorzata Kapral, Joanna Wawszczyk, Stanisław Sośnicki, Ludmiła Węglarz
Inflammatory bowel disease (IBD) is chronic inflammatory condition associated with increased risk of developing colorectal cancer. A number of mediators of inflammation, such as pro-inflammatory cytokines, prostaglandins and nitric oxide have been involved in carcinogenesis, especially in the promotion and progression stages. NO is synthesized from L-arginine by constitutively expressed endothelial and neuronal nitric oxide synthases (eNOS and nNOS, respectively) and an inducible NOS (iNOS) isoform expressed under inflammatory conditions...
July 2015: Acta Poloniae Pharmaceutica
https://www.readbyqxmd.com/read/26581571/conundrum-of-ip6
#19
COMMENT
Ivana Vucenik
Here are comments on the recent paper on the determination of inositol hexaphosphate (IP6) in human plasma and on its efficacy.
November 2015: Open Biology
https://www.readbyqxmd.com/read/26335902/cytotoxic-effect-of-inositol-hexaphosphate-and-its-ni-ii-complex-on-human-acute-leukemia-jurkat-t-cells
#20
Eliane May de Lima, Carla Cristine Kanunfre, Lucas Ferrari de Andrade, Daniel Granato, Neiva Deliberali Rosso
Inositol hexaphosphate (InsP6) is present in cereals, legumes, nuts and seed oils and is biologically active against some tumor and cancer cells. Herein, this study aimed at evaluating the cellular toxicity, antiproliferative activity and effects on cell cycle progression of free InsP6 and InsP6-Ni(II) of leukemic T (Jurkat) and normal human cells. Treatments with InsP6 at concentrations between 1.0 and 4.0mM significantly decreased the viability of Jurkat cells, but showed no cytotoxic effect on normal human lymphocytes...
December 2015: Toxicology in Vitro: An International Journal Published in Association with BIBRA
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