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https://www.readbyqxmd.com/read/29908353/the-impact-of-prenatal-diagnosis-on-congenital-anomaly-outcomes-data-from-1997-to-2016
#1
REVIEW
Paula Braz, Ausenda Machado, Carlos Matias Dias
The term prenatal diagnosis comprises a variety of techniques aimed to determine the health and condition of the embryo or foetus. Its main goal is to identify at an early stage of the pregnancy, if possible, malformations or other conditions that could increase the risk of a negative outcome in the pregnancy. The aim of this study was to assess the impact of prenatal diagnosis in Portugal in pregnancies with congenital anomalies. A cross sectional study was implemented using data for the years 1997-2016 from the Portuguese registry of congenital anomalies (RENAC), a population-based registry that follows EUROCAT guidelines...
June 13, 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29908329/the-incidence-of-vocal-fold-motion-impairment-after-primary-thyroid-and-parathyroid-surgery-for-a-single-high-volume-academic-surgeon-determined-by-pre-and-immediate-post-operative-fiberoptic-laryngoscopy
#2
Vaninder K Dhillon, Eleni Rettig, Salem I Noureldine, Dane J Genther, Ahmed Hassoon, Mai G Al Khadem, Ozan B Ozgursoy, Ralph P Tufano, Charles W Cummings
BACKGROUND: Vocal fold motion impairment (VFMI) is a well-recognized complication of thyroid and parathyroid surgery. Preoperative counseling requires a thorough understanding of the incidence, risk factors, and value of early diagnosis of postoperative VFMI. Our objective is to describe the incidence of and risk factors for VFMI for a single high-volume academic surgeon, and to assess the utility of immediate postoperative fiberoptic laryngoscopy (FOL) in early diagnosis of VFMI. METHODS: Retrospective cohort study of patients undergoing primary thyroid and parathyroid procedures by a single high-volume surgeon at an academic tertiary care center...
June 13, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29908282/the-function-and-clinical-significance-of-eif3-in-cancer
#3
REVIEW
Yuting Yin, Jiali Long, Yanqin Sun, Hongmei Li, Enping Jiang, Chao Zeng, Wei Zhu
Abnormal regulation of gene expression is essential for tumorigenesis. Several studies indicate that regulation of oncogene expression and neoplastic transformation are controlled by subunits of eukaryotic translation initiation factors (eIFs). Eukaryotic translation initiation factor 3 (eIF3) is the largest (800 kDa) and the most complex mammalian initiation factor. It is composed of 13 non-identical polypeptides designated as eIF3a-m and plays a pivotal role in protein synthesis that bridges the 43S pre-initiation complex and eIF4F-bound mRNA...
June 13, 2018: Gene
https://www.readbyqxmd.com/read/29908235/the-effect-of-antibiotics-on-social-aversion-following-early-life-inflammation
#4
Amanda C Kentner, Urma Khan, M MacRae, Scot E Dowd, Siyang Yan
Epidemiological evidence suggests that exposure to infection during early development increases the risk for neurodevelopmental disorders associated with symptoms such as a decreased desire to engage in social interactions. This disruption in social behavior can be modelled in animals by administering bacterial mimetics such as liposaccharide (LPS). However, when evaluating social interactions in the laboratory, attention is rarely directed on the reciprocal relationship as a whole, which is important as peers may drive social withdrawal...
June 13, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29908202/post-translational-protein-deimination-in-cod-gadus-morhua-l-ontogeny-novel-roles-in-tissue-remodelling-and-mucosal-immune-defences
#5
Bergljót Magnadóttir, Polly Hayes, Mariya Hristova, Birkir Þór Bragason, Anthony P Nicholas, Alister W Dodds, Sigríður Guðmundsdóttir, Sigrun Lange
Peptidylarginine deiminases (PADs) are calcium dependent enzymes with physiological and pathophysiological roles conserved throughout phylogeny. PADs promote post-translational deimination of protein arginine to citrulline, altering the structure and function of target proteins. Deiminated proteins were detected in the early developmental stages of cod from 11 days post fertilisation to 70 days post hatching. Deiminated proteins were present in mucosal surfaces and in liver, pancreas, spleen, gut, muscle, brain and eye during early cod larval development...
June 13, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29908152/reducing-readmissions-in-patients-with-both-heart-failure-and-chronic-obstructive-pulmonary-disease
#6
REVIEW
Ravi Kalhan, R Kannan Mutharasan
Patients with both chronic obstructive pulmonary disease (COPD) and heart failure (HF) pose particularly high costs to the healthcare system. These diseases arise from similar root causes, have overlapping symptoms, and share similar clinical courses. Because of these strong parallels, strategies to reduce readmissions in patients with both conditions share synergies. Here we present 10 practical tips to reduce readmissions in this challenging population. 1: Diagnose the population accurately. 2: Detect admissions for exacerbations early and consider risk-stratification...
June 13, 2018: Chest
https://www.readbyqxmd.com/read/29908082/the-role-of-sigma-1-receptor-in-sex-specific-heat-shock-response-in-an-experimental-rat-model-of-renal-ischemia-reperfusion-injury
#7
Adam Hosszu, Zsuzsanna Antal, Apor Veres-Szekely, Lilla Lenart, Dora Bianka Balogh, Edgar Szkibinszkij, Lilla Illesy, Judit Hodrea, Nora F Banki, Laszlo Wagner, Adam Vannay, Attila J Szabo, Andrea Fekete
We previously showed that female rats are more protected against renal ischemia/reperfusion (I/R) injury than males, which is partly attributed to their more pronounced heat shock response. We recently described that Sigma-1 receptor (S1R) activation improves postischemic survival and renal function. 17β-estradiol activates S1R, thus here we investigated the role of sex-specific S1R activation and heat shock response in severe renal I/R injury. Proximal tubular cells were treated with 17β-estradiol, which caused direct S1R activation and subsequent induction of heat shock response...
June 16, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29907975/metabolite-assignment-of-ultra-filtered-synovial-fluid-extracted-from-knee-joints-of-reactive-arthritis-patients-using-high-resolution-nmr-spectroscopy
#8
Durgesh Dubey, Smriti Chaurasia, Anupam Guleria, Sandeep Kumar, Dinesh Raj Modi, Ramnath Misra, Dinesh Kumar
Currently, there are no reliable clinical biomarkers available that can aid early differential diagnosis of reactive arthritis (ReA) from other inflammatory joint diseases. Metabolic profiling of synovial fluid (SF) -obtained from joints affected in ReA- holds great promise in this regard and will further aid monitoring treatment and improving our understanding about disease mechanism. As a first step in this direction, we report here the metabolite specific assignment of 1 H and 13 C resonances detected in the NMR spectra of SF samples extracted from human patients with established ReA...
June 15, 2018: Magnetic Resonance in Chemistry: MRC
https://www.readbyqxmd.com/read/29907939/feasibility-of-quantitative-ultrasonography-for-the-detection-of-metabolic-bone-disease-in-preterm-infants-systematic-review
#9
REVIEW
Liting Tong, Jaya Sujatha Gopal-Kothandapani, Amaka C Offiah
Metabolic bone disease of prematurity is characterised by disordered bone mineralisation and is therefore an increased fracture risk. Preterm infants are especially at risk due to incomplete in utero bone accretion during the last trimester. Currently, diagnosing metabolic bone disease mainly relies on biochemistry and radiographs. Dual-energy x-ray absorptiometry and quantitative ultrasound (US) are used less frequently. However, biochemical measurements correlate poorly with bone mineralisation and although scoring systems exist for metabolic bone disease, radiographs are subjective and do not detect early features of osteopenia...
June 16, 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29907853/monitoring-cerebral-oxygenation-of-the-immature-brain-a-neuroprotective-strategy
#10
REVIEW
Frank van Bel, Jonathan P Mintzer
Monitoring of cerebral oxygenation (rScO2 ) with near-infrared spectroscopy (NIRS) is a feasible noninvasive bedside technique in the NICU. This review discusses the possible neuroprotective role of "pattern recognition" of NIRS-derived rScO2 in preterm neonates with regard to the prevention of severe intraventricular hemorrhage and hypoxia/hyperoxia-related white matter injury. This neuroprotective role of rScO2 monitoring is discussed as a modality to aid in the early detection of cerebral oxygenation conditions predisposing to these complications...
June 15, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29907817/serum-proteomic-profiling-to-identify-biomarkers-of-premature-carotid-atherosclerosis
#11
Santosh D Bhosale, Robert Moulder, Mikko S Venäläinen, Juhani S Koskinen, Niina Pitkänen, Markus T Juonala, Mika A P Kähönen, Terho J Lehtimäki, Jorma S A Viikari, Laura L Elo, David R Goodlett, Riitta Lahesmaa, Olli T Raitakari
To evaluate the presence of serum protein biomarkers associated with the early phases of formation of carotid atherosclerotic plaques, label-free quantitative proteomics analyses were made for serum samples collected as part of The Cardiovascular Risk in Young Finns Study. Samples from subjects who had an asymptomatic carotid artery plaque detected by ultrasound examination (N = 43, Age = 30-45 years) were compared with plaque free controls (N = 43) (matched for age, sex, body weight and systolic blood pressure)...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29907659/overview-of-foot-and-mouth-disease-awareness-among-farmers-and-veterinarians-in-france
#12
Noémie Raut, Julie Rivière, Soline Hosteing, Eric Collin, Stéphanie Philizot, Olivier Debaere, Gina Zanella
Foot-and-mouth disease (FMD) is of major concern in most countries including Europe, where no outbreaks have occurred since a decade. Indeed, the risk of FMD introduction from infected countries is not negligible and the awareness of field stakeholders (farmers, veterinarians) is essential to ensure an effective detection of the viral circulation. The French veterinary services launched in 2015 a survey to estimate the awareness of farmers and veterinarians and their knowledge about epidemiological and regulatory aspects of FMD...
June 15, 2018: Veterinary Record
https://www.readbyqxmd.com/read/29907587/precision-prevention-and-early-detection-of-cancer-fundamental-principles
#13
Timothy R Rebbeck, Karen Burns-White, Andrew T Chan, Karen Emmons, Matthew Freedman, David J Hunter, Peter Kraft, Francine Laden, Lorelei Mucci, Giovanni Parmigiani, Deborah Schrag, Sapna Syngal, Rulla M Tamimi, Kasisomayajula Viswanath, Matthew B Yurgelun, Judy E Garber
Prevention and early detection is critical for reducing the population cancer burden. Two approaches have been used: Population approaches change social norms (e.g., smoking bans) or impose incentives (e.g., cigarette taxes); high-risk strategies intervene upon individuals with elevated cancer risk (e.g., smoking cessation). Knowledge about carcinogenesis mechanisms, extreme exposures, and inherited susceptibility provides opportunities to develop precision prevention and early-detection (PPED) strategies. PPED aims to understand the basis of risk, identify groups that optimally benefit from interventions, characterize heterogeneity in intervention responses, optimize intervention timing, and minimize toxicities...
June 15, 2018: Cancer Discovery
https://www.readbyqxmd.com/read/29907432/sensitivity-and-specificity-of-sentinel-lymph-node-biopsy-in-patients-with-oral-squamous-cell-carcinomas-using-indocyanine-green-fluorescence-imaging
#14
Ahmed Al-Dam, Clarissa Precht, Armelle Barbe, Carsten Kohlmeier, Henning Hanken, Johannes Wikner, Gerhard Schön, Max Heiland, Alexandre T Assaf
PURPOSE: The purpose of this clinical study was to evaluate the sensitivity and specificity of cervical sentinel lymph node biopsy after mapping with indocyanine green fluorescence (ICG) for imaging early-stage oral cancer. PATIENTS AND METHODS: A sentinel lymph node biopsy (SLNB) was performed during a selective neck dissection (SND) in 20 patients with oral squamous cell carcinoma (OSCC, cT1 or cT2, N0 status). The sentinel lymph nodes (SLN) were identified using an infrared video camera after ICG injection...
May 23, 2018: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29907291/bifunctional-aptamer-mediated-catalytic-hairpin-assembly-for-the-sensitive-and-homogenous-detection-of-rare-cancer-cells
#15
Jumei Liu, Ye Zhang, Qianwen Zhao, Bo Situ, Jiamin Zhao, Shihua Luo, Bo Li, Xiaohui Yan, Pankaj Vadgama, Lei Su, Wen Ma, Wen Wang, Lei Zheng
The presence of cancer cells in body fluids confirms the occurrence of metastasis and guides treatment. A simple, fast, and homogeneous fluorescent method was developed to detect cancer cells based on catalytic hairpin assembly (CHA) and bifunctional aptamers. The bifunctional aptamer had a recognition domain for binding to target cancer cells and an initiator domain for triggering the CHA reaction. In the presence of target cells, the bifunctional aptamer was released from the inhibitor and initiated a cascade reaction of assembly and disassembly of the hairpins...
October 31, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29907286/a-novel-mode-of-dna-assembly-at-electrode-and-its-application-to-protein-quantification
#16
Shaohua Ding, Zhipeng Gu, Ruhong Yan, Yuguo Tang, Peng Miao
Sensitive and specific detection of protein is of great significance for early diagnosis and prognosis of many diseases. However, great challenges remain unsolved including relative low sensitivity, high cost, long testing time, complicated instrument and laborious operation. To improve the performance of protein detection methods, development of fine reaction interface for recognition and signal amplification is of great importance. In this work, we construct a novel mode of DNA assembly at electrode interface based on a tripodal surface anchor and an electrochemical aptasensor for protein assay is developed...
October 31, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29907246/cognitive-impairment-and-the-association-between-frailty-and-functional-deficits-are-linked-to-abdominal-obesity-in-the-elderly
#17
Assaf Buch, Eli Carmeli, Gabi Shefer, Lital Keinan-Boker, Yitshal Berner, Yonit Marcus, Rebecca Goldsmith, Naftali Stern
OBJECTIVE: To evaluate whether specific obesity phenotypes in community-dwelling elderly: (a) affect differently the relationship between frailty and functional impairment and (b) are related to cognitive impairment. STUDY DESIGN: A post-hoc cross-sectional analysis of the last Israeli national health and nutrition survey of the elderly (≥ 65 yrs.; n = 1619). MAIN OUTCOME MEASURES: We implemented a previously validated frailty model based on frailty-related variables that were obtained in the survey...
August 2018: Maturitas
https://www.readbyqxmd.com/read/29907197/the-importance-of-presepsin-value-in-detection-of-gastrointestinal-anastomotic-leak-a-pilot-study
#18
Murat Cikot, Pinar Kasapoglu, Nilgun Isiksacan, Sinan Binboga, Osman Kones, Eyup Gemici, Bahadır Kartal, Halil Alis
BACKGROUND: Early diagnosis of anastomotic leakage is the most important factor in reducing its morbidity and mortality. Anastomotic integrity monitoring of the leukocyte count (WBC), C-reactive protein (CRP), and neutrophil-lymphocyte ratio (NLR) are commonly used laboratory parameters. The availability of follow-up presepsin anastomotic integrity was investigated in this study. MATERIALS AND METHODS: This study included patients who had gastrointestinal anastomosis due to major abdominal surgery between January 2016 and February 2017...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29907142/malbac-based-chromosomal-imbalance-analysis-a-novel-technique-enabling-effective-non-invasive-diagnosis-and-monitoring-of-bladder-cancer
#19
Hao Liu, Wang He, Bo Wang, Kewei Xu, Jinli Han, Junjiong Zheng, Jun Ren, Lin Shao, Shiping Bo, Sijia Lu, Tianxin Lin, Jian Huang
BACKGROUND: The gold standard for bladder cancer detection is cystoscopy, which is an invasive procedure that causes discomfort in patients. The currently available non-invasive approaches either show limited sensitivity in low-grade tumours or possess unsatisfying specificity. The aim of the present study is to develop a new non-invasive strategy based on chromosomal imbalance levels to detect bladder cancer effectively. METHODS: We enrolled 74 patients diagnosed with bladder cancer (BC), 51 healthy participants and 27 patients who were diagnosed with non-malignant urinary disease (UD)...
June 15, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29906730/fate-of-methoprene-in-temperate-salt-marsh-ditches-following-aerial-applications
#20
David J Tonjes, Anne E McElroy, Robin K Barnes-Pohjonen, Dominick V Ninivaggi, Walter Dawydiak, Gregory T Greene, Bruce J Brownawell
Aerial applications of liquid methoprene are used in salt marshes to control mosquitoes by preventing adult emergence. Despite concern about toxicity to non-target organisms, little is known about environmental concentrations after applications, nor methoprene's persistence in salt marsh environments. Aqueous and sediment samples were collected from two marshes receiving weekly applications. Aqueous samples were collected as early as 30 min after applications and as long as nine days afterwards; sediment samples were taken within hours of application and as long as 19 days post-application...
June 12, 2018: Science of the Total Environment
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