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https://www.readbyqxmd.com/read/29691957/very-long-term-outcome-of-schizophrenia
#1
REVIEW
Jan Volavka, Jan Vevera
PURPOSE: The principal aim is to review recent data concerning the very long-term outcome of schizophrenia and schizophrenia spectrum disorders. We examine factors that influence outcome, including therapeutic interventions. METHOD: PubMed and Scopus databases were searched for papers published between 2008 and 2017 reporting on prospective studies of schizophrenia or schizophrenia spectrum with a follow-up period ≥5 years with adequate outcome information. Additional publications were found in reference lists and authors' reference libraries...
April 24, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29691954/children-s-neural-processing-of-moral-scenarios-provides-insight-into-the-formation-and-reduction-of-in-group-biases
#2
Kimberly L Meidenbauer, Jason M Cowell, Jean Decety
Survival is dependent on sociality within groups which ensure sustenance and protection. From an early age, children show a natural tendency to sort people into groups and discriminate among them. The computations guiding evaluation of third-party behaviors are complex, requiring integration of intent, consequences, and knowledge of group affiliation. This study examined how perceiving third-party morally laden behavior influences children's likelihood to exhibit or reduce group bias. Following a minimal group paradigm assignment, young children (4-7 years) performed a moral evaluation task where group affiliations and moral actions were systematically juxtaposed, so that they were exposed to disproportionately antisocial in-group and prosocial out-group scenarios...
April 25, 2018: Developmental Science
https://www.readbyqxmd.com/read/29691850/tissue-distribution-shedding-and-environmental-detection-of-infectious-bursal-disease-virus-genome-following-infection-of-meat-chickens-at-two-ages
#3
Jmkgk Jayasundara, S W Walkden-Brown, Afmf Islam, M E Katz, K G Renz
OBJECTIVE: To compare the effects of infectious bursal disease virus (IBDV) infection of commercial meat chickens at 0 and 16 days old (d.o.) and determine if IBDV vRNA is quantifiable in litter and dust samples. METHODS: Ross meat chickens (n = 60) were orally infected or not with IBDV at 0 or 16 d.o. Blood and faecal samples were collected longitudinally to 28 days post infection (dpi) from six chickens and tissues collected weekly from three euthanased chickens...
May 2018: Australian Veterinary Journal
https://www.readbyqxmd.com/read/29691813/comparison-of-healing-of-full-thickness-skin-wounds-grafted-with-multidirectional-or-unidirectional-autologous-artificial-dermis-differential-delivery-of-healing-biomarkers
#4
M R Fontanilla, S Casadiegos, R H Bustos, M A Patarroyo
Cytokines, chemokines, and growth and remodeling factors orchestrate wound healing when skin damage occurs. During early stages, when the wound is still open, detection and quantification of these compounds might provide biomarkers of skin wound healing, which could aid to complete the scenario provided by clinical follow-up data and histological and histomorphometric analyses. This work assessed and compared the healing of full-thickness skin wounds grafted with artificial dermis made with autologous skin fibroblasts and unidirectional or multidirectional type I collagen scaffolds to test this hypothesis...
April 24, 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29691732/impact-of-the-cyp3a5-1-allele-on-the-pharmacokinetics-of-tacrolimus-in-japanese-heart-transplant-patients
#5
Takaya Uno, Kyoichi Wada, Sachi Matsuda, Yuka Terada, Akira Oita, Atsushi Kawase, Mitsutaka Takada
BACKGROUND AND OBJECTIVE: Tacrolimus, a major immunosuppressant used after transplantation, is associated with large interindividual variation involving genetic polymorphisms in metabolic processes. A common variant of the cytochrome P450 (CYP) 3A5 gene, CYP3A5*3, affects blood concentrations of tacrolimus. However, tacrolimus pharmacokinetics at the early stage of transplantation have not been adequately studied in heart transplantation. We retrospectively examined the impact of the CYP3A5 genotype on tacrolimus pharmacokinetics at the early stage of heart transplantation...
April 24, 2018: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/29691705/retinal-dysfunction-in-a-presymptomatic-patient-with-huntington-s-disease
#6
Jonelle Knapp, Dean A VanNasdale, Keith Ramsey, Julie Racine
PURPOSE: Huntington's disease (HD) is an autosomal dominant, neurodegenerative disorder characterized by progressive motor dysfunction, cognitive decline, and psychiatric disturbances. Studies have shown retinal abnormalities in patients and mouse models with HD; however, to our knowledge, no prior research papers evaluated retinal structure and function in a presymptomatic patient with HD. The aim of this report is to present a case of retinal dysfunction in a presymptomatic patient with HD...
April 24, 2018: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/29691673/multi-panel-assay-of-serum-autoantibodies-in-colorectal-cancer
#7
Mitsunori Ushigome, Yoshihiro Nabeya, Hiroaki Soda, Nobuhiro Takiguchi, Akiko Kuwajima, Masatoshi Tagawa, Kazuyuki Matsushita, Junichi Koike, Kimihiko Funahashi, Hideaki Shimada
BACKGROUND: Although serum p53 autoantibodies (s-p53-Abs) are induced even in the early stages of colorectal cancer, their positive rate is only approximately 20%. Therefore, we assessed the possibility of using other serum autoantibodies to increase the positive rates for detecting colorectal cancer. METHODS: Autoantibodies against 17 tumor antigens (p53, RalA, HSP70, Galectin1, KM-HN-1, NY-ESO-1, p90, Sui1, HSP40, CyclinB1, HCC-22-5, c-myc, PrxVI, VEGF, HCA25a, p62, and Annexin II) were evaluated in 279 patients with colorectal cancer and 74 healthy controls...
April 24, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29691643/the-relationship-between-timing-of-prasugrel-pretreatment-and-in-stent-thrombus-immediately-after-percutaneous-coronary-intervention-for-acute-coronary-syndrome-an-optical-coherence-tomography-study
#8
Yosuke Katayama, Takashi Kubo, Yasushi Ino, Takeyoshi Kameyama, Yoshiki Matsuo, Hironori Kitabata, Kosei Terada, Hiroki Emori, Hiroshi Aoki, Akira Taruya, Kunihiro Shimamura, Shingo Ota, Atsushi Tanaka, Takeshi Hozumi, Takashi Akasaka
The optimal timing of pretreatment with prasugrel in percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) is unclear. We used optical coherence tomography (OCT) to compare in-stent thrombus volume immediately after PCI between the administration of low-dose prasugrel (20 mg loading dose) at the time of diagnosis of ACS (early prasugrel: n = 34) and the administration of low-dose prasugrel immediately after diagnostic angiography prior to PCI for ACS (late prasugrel: n = 56). The durations between the administration of prasugrel and OCT in the early prasugrel group and late prasugrel group were 5...
April 24, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29691363/detection-of-circulating-mycobacterium-tuberculosis-specific-dna-by-droplet-digital-pcr-for-vaccine-evaluation-in-challenged-monkeys-and-tb-diagnosis
#9
Neng Song, Yang Tan, Lingyun Zhang, Wei Luo, Qing Guan, Ming-Zhe Yan, Ruiqi Zuo, Weixiang Liu, Feng-Ling Luo, Xiao-Lian Zhang
Mycobacterium tuberculosis (M. tb) is emerging as a more serious pathogen due to the increased multidrug-resistant TB and co-infection of human immunodeficiency virus (HIV). The development of an effective and sensitive detection method is urgently needed for bacterial load evaluation in vaccine development, early TB diagnosis, and TB treatment. Droplet digital polymerase chain reaction (ddPCR) is a newly developed sensitive PCR method for the absolute quantification of nucleic acid concentrations. Here, we used ddPCR to quantify the circulating virulent M...
April 24, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29691162/bioimpedance-spectroscopy-as-a-practical-tool-for-the-early-detection-and-prevention-of-protein-energy-wasting-in-hemodialysis-patients
#10
Marta Arias-Guillén, Eduardo Perez, Patricia Herrera, Bárbara Romano, Raquel Ojeda, Manel Vera, José Ríos, Néstor Fontseré, Francisco Maduell
OBJECTIVES: To evaluate whether body composition monitor (BCM) could be a practical instrument for nephrologists to assess nutritional status in patients on hemodialysis (HD) and whether it is more effective in identifying patients at highest risk of developing protein-energy wasting (PEW) alone or in combination with other tools currently used for that purpose. DESIGN: Observational cross-sectional study in 91 HD patients (60 ± 14 years, 70.3% male, 24 ± 4...
April 21, 2018: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29691141/corrigendum-to-fecal-clostridium-symbiosum-for-noninvasive-detection-of-early-and-advanced-colorectal-cancer-test-and-validation-studies-ebiomedicine-25-2017-32-40
#11
Yuan-Hong Xie, Qin-Yan Gao, Guo-Xiang Cai, Xiao-Min Sun, Tian-Hui Zou, Hui-Min Chen, Si-Yi Yu, Yi-Wen Qiu, Wei-Qi Gu, Xiao-Yu Chen, Yun Cui, Danfeng Sun, Zhan-Ju Liu, San-Jun Cai, Jie Xu, Ying-Xuan Chen, Jing-Yuan Fang
No abstract text is available yet for this article.
February 20, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29691123/a-computer-aided-detection-of-the-architectural-distortion-in-digital-mammograms-using-the-fractal-dimension-measurements-of-bemd
#12
Imad Zyout, Roberto Togneri
Achieving a high performance for the detection and characterization of architectural distortion in screening mammograms is important for an efficient breast cancer early detection. Viewing a mammogram image as a rough surface that can be described using the fractal theory is a well-recognized approach. This paper presents a new fractal-based computer-aided detection (CAD) algorithm for characterizing various breast tissues in screening mammograms with a particular focus on distinguishing between architectural distortion and normal breast parenchyma...
April 3, 2018: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/29690884/capsaicin-enriched-diet-ameliorates-autoimmune-neuritis-in-rats
#13
Jeremias Motte, Björn Ambrosius, Thomas Grüter, Hussein Bachir, Melissa Sgodzai, Xiomara Pedreiturria, Kalliopi Pitarokoili, Ralf Gold
BACKGROUND: Autoimmune neuropathies are common PNS disorders and effective treatment is challenging. Environmental influence and dietary components are known to affect the course of autoimmune diseases. Capsaicin as pungent component of chili-peppers is common in human nutrition. An influence of capsaicin on autoimmune diseases has been postulated. METHODS: We tested capsaicin in the animal model of experimental autoimmune neuritis (EAN) in Lewis rat. Rats were immunized with P2-peptide and were treated with capsaicin in different preventive settings...
April 24, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29690821/severe-traumatic-brain-injury-induces-early-changes-in-the-physical-properties-and-protein-composition-of-intracranial-extracellular-vesicles
#14
Janja Kuharić, Kristina Grabusic, Vlatka Sotosek Tokmadzic, Sanja Štifter, Ksenija Tulić, Olga Shevchuk, Pero Lučin, Alan Šustić
Extracellular vesicles (EVs) are membranous nanostructures that can indicate undergoing processes in organs and thus help in diagnostics and prognostics. They are secreted by all cells, contained in body fluids and able to transfer proteins, lipids and nucleic acids to distant cells. Intracranial EVs were shown to change their composition after severe traumatic brain injury (TBI) and therefore to have biomarker potential to evaluate brain events. However, properties of intracranial EVs early after TBI have not been characterized...
April 25, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29690753/correlation-between-regional-tissue-perfusion-saturation-and-lactate-level-during-cardiopulmonary-bypass
#15
Yoon-Sook Lee, Woon Young Kim, Ji Won Yoo, Hyun Don Jung, Too Jae Min
Background: Cardiopulmonary bypass (CPB) can cause systemic hypoperfusion, which remains undetected by routine monitoring of physiological parameters. Noninvasive tissue perfusion monitoring offers a clinical benefit by detecting low systemic perfusion. In this study, we tried to evaluate whether regional tissue perfusion saturation reflects systemic hypoperfusion during CPB. Methods: This retrospective study included 29 patients with American Society of Anesthesiologists physical status II-III, who required cardiac surgery with CPB...
April 25, 2018: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/29690740/-effects-of-exogenous-high-mobility-group-protein-box-1-on-angiogenesis-in-ischemic-zone-of-early-scald-wounds-of-rats
#16
L Dai, X Guo, H J Huang, X M Liao, X Q Luo, D Li, H Zhou, X C Gao, M Y Tan
Objective: To observe effects of exogenous high mobility group protein box 1 (HMGB1) on angiogenesis in ischemic zone of early scald wounds of rats. Methods: Thirty-six Sprague-Dawley rats were divided into HMGB1 group and simple scald (SS) group according to the random number table, with 18 rats in each group. Comb-like copper mould was placed on the back of rats for 20 s after being immersed in 100 ℃ hot water for 3 to 5 min to make three ischemic zones of wound. Immediately after scald, rats in HMGB1 group were subcutaneously injected with 0...
April 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29690708/-effect-of-transient-ischemic-attack-on-early-neurological-deterioration-in-patients-with-ipsilateral-ischemic-stroke
#17
S S Cao, A L Lin, L Sun, H Liang, Y Cheng, Y W Xu
Objective: To explore the effect of anterior circulation transient ischemic attack (TIA) on early neurological deterioration (END) in patients with ipsilateral ischemic stroke and its mechanism. Methods: (1) One hundred and thirteen patients with ipsilateral ischemic stroke and 36 healthy volunteers (healthy control group) in Neurology Department of Tianjin Medical University General Hospital from November 2014 to July 2015 were recruited into this study. According to whether got TIA before ischemic stroke, patients were divided into simple ischemic stroke group (CI group, n =87) and TIA-CI group ( n =26)...
April 3, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29690513/research-progress-on-rolling-circle-amplification-rca-based-biomedical-sensing
#18
REVIEW
Lide Gu, Wanli Yan, Le Liu, Shujun Wang, Xu Zhang, Mingsheng Lyu
Enhancing the limit of detection (LOD) is significant for crucial diseases. Cancer development could take more than 10 years, from one mutant cell to a visible tumor. Early diagnosis facilitates more effective treatment and leads to higher survival rate for cancer patients. Rolling circle amplification (RCA) is a simple and efficient isothermal enzymatic process that utilizes nuclease to generate long single stranded DNA (ssDNA) or RNA. The functional nucleic acid unit (aptamer, DNAzyme) could be replicated hundreds of times in a short period, and a lower LOD could be achieved if those units are combined with an enzymatic reaction, Surface Plasmon Resonance, electrochemical, or fluorescence detection, and other different kinds of biosensor...
April 21, 2018: Pharmaceuticals
https://www.readbyqxmd.com/read/29689750/universal-newborn-hearing-screening-using-a-teoae-and-a-abr-the-experience-of-a-large-public-hospital
#19
F Cianfrone, F Mammarella, M Ralli, V Evetovic, C M Pianura, G Bellocchi
BACKGROUND: Universal newborn hearing screening (UNHS) aims to identify hearing loss in the early postnatal period; prompt detection of bilateral or unilateral hearing loss is mandatory for timely intervention. METHODS: This retrospective study reports the results of the first two years of a UNHS program on 4,719 newborns in a large public Italian hospital. Screening was divided into two levels: automated transient otoacoustic emissions were used for first level; automated auditory brainstem response for second level...
2018: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29689721/reaction-of-amyloid-%C3%AE-peptide-antibody-with-different-infectious-agents-involved-in-alzheimer-s-disease
#20
Aristo Vojdani, Elroy Vojdani, Evan Saidara, Datis Kharrazian
As early as the 1980s, molecular virologist Ruth Itzhaki began to investigate if there was a causal connection between infections and neurodegenerative disorder. Although the theory has yet to be universally embraced, in 2016 Itzhaki and 33 other scientists from all over the world published a review article in this very journal presenting evidence for the causal role of pathogens in Alzheimer's disease (AD). Exactly how and in what way pathogens affect the induction of AD has yet to be determined, but one possible answer may involve the cross-reactivity of different pathogens with amyloid-β (Aβ)...
April 14, 2018: Journal of Alzheimer's Disease: JAD
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