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https://www.readbyqxmd.com/read/28636168/improved-hemodialysis-with-hemocompatible-polyethersulfone-hollow-fiber-membranes-in-vitro-performance
#1
Surendra Kumar Verma, Akshay Modi, Atul Kumar Singh, Rohit Teotia, Jayesh Bellare
We show that addition of nanozeolite (NZ) and vitamin E D-α-Tocopherol polyethylene glycol succinate (TPGS or T) considerably improves the performance of polyethersulfone (PES or P) hollow fiber membrane (HFM) for hemodialysis. Nanocomposite HFMs were manufactured using PES as a polymer, TPGS as an additive and NZ as a filler to give a composite membrane called PT-NZ. HFMs were spun by dry-wet spinning principle based on liquid-liquid phase separation. TPGS and NZ were successfully incorporated in HFMs, as confirmed by EDX elemental mapping...
June 21, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28634715/regulatory-element-based-prediction-identifies-new-susceptibility-regulatory-variants-for-osteoporosis
#2
Shi Yao, Yan Guo, Shan-Shan Dong, Ruo-Han Hao, Xiao-Feng Chen, Yi-Xiao Chen, Jia-Bin Chen, Qing Tian, Hong-Wen Deng, Tie-Lin Yang
Despite genome-wide association studies (GWASs) have identified many susceptibility genes for osteoporosis, it still leaves a large part of missing heritability to be discovered. Integrating regulatory information and GWASs could offer new insights into the biological link between the susceptibility SNPs and osteoporosis. We generated five machine learning classifiers with osteoporosis-associated variants and regulatory features data. We gained the optimal classifier and predicted genome-wide SNPs to discover susceptibility regulatory variants...
June 20, 2017: Human Genetics
https://www.readbyqxmd.com/read/28633292/ahp2-ahp3-and-ahp5-act-downstream-of-cki1-in-arabidopsis-female-gametophyte-development
#3
Zhenning Liu, Li Yuan, Xiaoya Song, Xiaolin Yu, Venkatesan Sundaresan
Histidine phosphotransfer proteins (HPs) are key elements of the two-component signaling system, which act as a shuttle to transfer phosphorylation signals from histidine kinases (HKs) to response regulators (RRs). CYTOKININ INDEPENDENT 1 (CKI1), a key regulator of central cell specification in the Arabidopsis female gametophyte, activates the cytokinin signaling pathway through the Arabidopsis histidine phosphotransfer proteins (AHPs). There are five HP genes in Arabidopsis, AHP1-AHP5, but it remains unknown which AHP genes act downstream of CKI1 in Arabidopsis female gametophyte development...
June 13, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28633065/differential-accumulation-of-pahs-elements-and-pb-isotopes-by-five-lichen-species-from-the-athabasca-oil-sands-region-in-alberta-canada
#4
Joseph R Graney, Matthew S Landis, Keith J Puckett, William B Studabaker, Eric S Edgerton, Allan H Legge, Kevin E Percy
A 2014 case study investigated the relative accumulation efficiency of polycyclic aromatic hydrocarbons (PAHs), total sulfur (S), total nitrogen (N), major and minor elements and Pb isotopes in five common lichen species at three boreal forest sites in the Athabasca Oil Sands Region (AOSR) in northeastern Alberta, Canada to identify the optimum lichen species for future biomonitoring. Differences in concentrations of PAHs, multiple elements, and Pb isotopes in fruticose (Bryoria furcellata, Cladina mitis, Evernia mesomorpha) and foliose (Hypogymnia physodes and Tuckermannopsis americana) lichens were found along a 100 km distance gradient from the primary oil sands operations...
June 10, 2017: Chemosphere
https://www.readbyqxmd.com/read/28632407/prediction-of-the-structural-response-of-the-femoral-shaft-under-dynamic-loading-using-subject-specific-finite-element-models
#5
Gwansik Park, Taewung Kim, Jason Forman, Matthew B Panzer, Jeff R Crandall
The goal of this study was to predict the structural response of the femoral shaft under dynamic loading conditions using subject-specific finite element (SS-FE) models and to evaluate the prediction accuracy of the models in relation to the model complexity. In total, SS-FE models of 31 femur specimens were developed. Using those models, dynamic three-point bending and combined loading tests (bending with four different levels of axial compression) of bare femurs were simulated, and the prediction capabilities of five different levels of model complexity were evaluated based on the impact force time histories: baseline, mass-based scaled, structure-based scaled, geometric SS-FE, and heterogenized SS-FE models...
June 20, 2017: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/28631340/insights-into-the-genomic-plasticity-of-pseudomonas-putida-kf715-a-strain-with-unique-biphenyl-utilizing-activity-and-genome-instability-properties
#6
Hikaru Suenaga, Hidehiko Fujihara, Nobutada Kimura, Jun Hirose, Takahito Watanabe, Taiki Futagami, Masatoshi Goto, Jun Shimodaira, Kensuke Furukawa
Pseudomonas putida KF715 exhibits unique properties in both catabolic activity and genome plasticity. Our previous studies revealed that the DNA region containing biphenyl and salycilate metabolism gene clusters (termed the bph-sal element) was frequently deleted and transferred by conjugation to closely related P. putida strains. In this study, we first determined the complete nucleotide sequence of the KF715 genome. Next, to determine the underlying cause of genome plasticity in KF715, we compared the KF715 genome with the genomes of one KF715 defective mutant, two transconjugants, and several P...
June 19, 2017: Environmental Microbiology Reports
https://www.readbyqxmd.com/read/28630153/membrane-spanning-%C3%AE-helical-barrels-as-tractable-protein-design-targets
#7
REVIEW
Ai Niitsu, Jack W Heal, Kerstin Fauland, Andrew R Thomson, Derek N Woolfson
The rational (de novo) design of membrane-spanning proteins lags behind that for water-soluble globular proteins. This is due to gaps in our knowledge of membrane-protein structure, and experimental difficulties in studying such proteins compared to water-soluble counterparts. One limiting factor is the small number of experimentally determined three-dimensional structures for transmembrane proteins. By contrast, many tens of thousands of globular protein structures provide a rich source of 'scaffolds' for protein design, and the means to garner sequence-to-structure relationships to guide the design process...
August 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28628311/pushing-the-limits-of-oxygen-balance-in-1-3-4-oxadiazoles
#8
Qiong Yu, Ping Yin, Jiaheng Zhang, Chunlin He, Gregory Howard Imler, Damon A Parrish, Jean'ne M Shreeve
Gem-trinitromethyl groups were introduced into a 1,3,4-oxadiazole ring to give the first example of a bifunctionalized single five-membered ring with six nitro groups. 2,5-Bis(trinitromethyl)-1,3,4-oxadiazole (12) has a high calculated crystal density of 2.007 g cm-3 at 150 K and a very high positive oxygen balance (39.12%) which make it a strong candidate as a high energy dense oxidizer. The dihy-droxylammonium and dihydrazinium salts of bis(trinitromethyl)-1,3,4-oxadiazole (5 and 6) exhibit excel-lent detonation properties (5, vD = 9266 m s-1, P = 38...
June 19, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28627861/effectiveness-of-aquatic-therapy-for-the-control-of-pain-and-increased-functionality-in-people-with-parkinson-s-disease-a-randomized-clinical-trial
#9
Sagrario Pérez de la Cruz
BACKGROUND: Gait, balance disorders and pain associated with Parkinson's disease represent important therapeutic challenges, as they are related with an increased risk of falls, together with disability and physical decline. AIM: To compare the effects of an aquatic Ai Chi training program on the perception of pain, the maintenance of balance and the functional independence of patients with Parkinson's disease. DESIGN: A single-blind randomized controlled trial...
June 19, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28625055/low-thermal-conductivity-and-high-thermoelectric-performance-in-gete-1-2x-gese-x-ges-x-competition-between-solid-solution-and-phase-separation
#10
Manisha Samanta, Kanishka Biswas
GeTe and its derivatives constituting Pb-free elements are well known as potential thermoelectric materials for the last five decades which offer paramount technological importance. The main constrain in the way of optimizing thermoelectric performance of GeTe is the high lattice thermal conductivity (κlat). Herein, we demonstrate low κlat (~0.7 W/mK) and significantly high thermoelectric figure of merit (ZT = 2.1 at 630 K) in Sb doped pseudoternary (GeTe)1-2x(GeSe)x(GeS)x system by two step strategies. (GeTe)1-2x(GeSe)x(GeS)x system provides an excellent podium to investigate competition between entropy driven solid solution and enthalpy driven phase separation...
June 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28624354/school-reintegration-of-pediatric-burn-survivors-an-integrative-literature-review
#11
REVIEW
Raquel Pan, Bruna Domingos Dos Santos, Lucila Castanheira Nascimento, Lídia Aparecida Rossi, Rinie Geenen, Nancy E Van Loey
BACKGROUND: The school is an essential context for children's social interaction with peers and to develop academic skills. Therefore, a fast reintegration can help children with burns to normalize their life. Thus, school reintegration is an important outcome after burns. The aim of this review was to systematically synthesize the literature addressing school reintegration programs of pediatric burns survivors. METHODS: Five electronic databases were searched independently by two reviewers...
June 14, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28624261/dutch-health-websites-and-their-ability-to-inform-people-with-low-health-literacy
#12
Corine S Meppelink, Julia C M van Weert, Anna Brosius, Edith G Smit
OBJECTIVE: To evaluate whether Dutch online health information (OHI) generally reflects message elements that support information processing and understanding among people with low health literacy. METHODS: We content-analyzed one hundred Dutch webpages about Ebola, fibromyalgia, ALS, losing weight, borderline personality disorder, hemorrhoids, ADD, bladder infection, shingles, and chicken pox. The codebook covered the following domains: images and videos, readability level, Suitability Assessment of Materials (SAM), advertising, interactive features, and reliability cues...
June 10, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28623812/discovery-of-non-spherical-heterogeneous-radiocesium-bearing-particles-not-derived-from-unit-1-of-the-fukushima-dai-ichi-nuclear-power-plant-in-residences-five-years-after-the-accident
#13
Shogo Higaki, Yuichi Kurihara, Hiroko Yoshida, Yoshio Takahashi, Naohide Shinohara
Non-spherical heterogeneous radiocesium-bearing particles were found on masks worn during cleaning work in residences near the Fukushima Dai-ichi Nuclear Power Plant (FDNPP), from which residents had evacuated. Three slightly larger (6.6-12 μm) non-spherical radiocesium-bearing particles were found in a residence in Futaba Town, a straight distance of 2.11 km west-northwest from the FDNPP. These were collected on October 25, 2016, 5 years and 7 months after the Fukushima Dai-ichi nuclear disaster and were presumed to originate from the Plant's Unit 2 based on the measured radioactivity ratio of (134)Cs/(137)Cs...
June 14, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28623799/assessment-of-species-specific-and-temporal-variations-of-major-trace-and-rare-earth-elements-in-vineyard-ambient-using-moss-bags
#14
Tijana Milićević, M Aničić Urošević, Gordana Vuković, Sandra Škrivanj, Dubravka Relić, Marina V Frontasyeva, Aleksandar Popović
Since the methodological parameters of moss bag biomonitoring have rarely been investigated for the application in agricultural areas, two mosses, Sphagnum girgensohnii (a species of the most recommended biomonitoring genus) and Hypnum cupressiforme (commonly available), were verified in a vineyard ambient. The moss bags were exposed along transects in six vineyard parcels during the grapevine season (March‒September 2015). To select an appropriate period for the reliable 'signal' of the element enrichment in the mosses, the bags were simultaneously exposed during five periods (3 × 2 months, 1 × 4 months, and 1 × 6 months)...
June 14, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28623752/process-evaluation-of-a-multi-component-self-management-intervention-for-adults-with-epilepsy-zmile-study
#15
Loes A M Leenen, Ben F M Wijnen, Jolanda C M van Haastregt, Reina J A de Kinderen, Silvia M A A Evers, Marian H J M Majoie, Caroline M van Heugten
BACKGROUND: People with epilepsy need to monitor and manage their symptoms. They, as well as their relatives, have to deal with the psychological burden, reflected in a reduced quality of life. Support in self-management can be of importance. We have developed a multi-component self-management intervention for patients and their relatives (MCI). This eight-week group intervention is conducted by nurse practitioners and consists of six two-hour sessions. The main components are: 1) providing self-management education, 2) stimulating proactive coping and goal-setting and 3) facilitating peer and social support...
June 14, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28622020/the-effect-of-direct-and-indirect-force-transmission-on-peri-implant-bone-stress-a-contact-finite-element-analysis
#16
Annike Rand, Meike Stiesch, Michael Eisenburger, Andreas Greuling
In almost all finite element (FE) studies in dentistry, virtual forces are applied directly to dentures. The purpose of this study was to develop a FE model with non-linear contact simulation using an antagonist as force transmitter and to compare this with a similar model that uses direct force transmission. Furthermore, five contact situations were created in order to examine their influence on the peri-implant bone stresses, which are relevant to the survival rate of implants. It was found that the peri-implant bone stresses were strongly influenced by the kind of force transmission and contact number...
August 2017: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/28620726/determination-of-the-cadmium-chromium-nickel-and-lead-ions-relays-in-selected-polish-medicinal-plants-and-their-infusion
#17
Janusz Mirosławski, Andrzej Paukszto
Concentration of Cd, Cr, Ni, and Pb were determined in peppermint leaves (Folium Menthae piperitae), chamomile blossom (Anthodium Chamomillae), and their infusions by atomic absorption spectrometry (AAS) after microwave digestion of plants samples. Peppermint and chamomile preparations by five different producers were purchased at various pharmacies in Poland. Infusions were made from herbs according to prescription for patients, provided by the producer of medicine on the package. Results show that in exam of medicinal plants the content of cadmium exceeds World Health Organization (WHO) standards...
June 15, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28620378/nature-and-consequences-of-biological-reductionism-for-the-immunological-study-of-infectious-diseases
#18
REVIEW
Ariel L Rivas, Gabriel Leitner, Mark D Jankowski, Almira L Hoogesteijn, Michelle J Iandiorio, Stylianos Chatzipanagiotou, Anastasios Ioannidis, Shlomo E Blum, Renata Piccinini, Athos Antoniades, Jane C Fazio, Yiorgos Apidianakis, Jeanne M Fair, Marc H V Van Regenmortel
Evolution has conserved "economic" systems that perform many functions, faster or better, with less. For example, three to five leukocyte types protect from thousands of pathogens. To achieve so much with so little, biological systems combine their limited elements, creating complex structures. Yet, the prevalent research paradigm is reductionist. Focusing on infectious diseases, reductionist and non-reductionist views are here described. The literature indicates that reductionism is associated with information loss and errors, while non-reductionist operations can extract more information from the same data...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28618367/recent-advances-in-transition-metal-dichalcogenides-based-electrochemical-biosensors-a-review
#19
REVIEW
Yi-Han Wang, Ke-Jing Huang, Xu Wu
Layered transition metal dichalcogenides (TMDCs) comprise a category of two-dimensional (2D) materials that offer exciting properties, including large surface area, metallic and semi-conducting electrical capabilities, and intercalatable morphologies. Biosensors employ biological molecules to recognize the target and utilize output elements which can translate the biorecognition event into electrical, optical or mass-sensitive signals to determine the quantities of the target. TMDCs nanomaterials have been widely applied in various electrochemical biosensors with high sensitivity and selectivity...
June 8, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28610811/human-factors-in-mental-healthcare-a-work-system-analysis-of-a-community-based-program-for-older-adults-with-depression-and-dementia
#20
Siobhan M Heiden, Richard J Holden, Catherine A Alder, Kunal Bodke, Malaz Boustani
Mental healthcare is a critical but largely unexplored application domain for human factors/ergonomics. This paper reports on a work system evaluation of a home-based dementia and depression care program for older adults, the Aging Brain Care program. The Workflow Elements Model was used to guide data collection and analysis of 59 h of observation, supplemented by key informant input. We identified four actors, 37 artifacts across seven types, ten action categories, and ten outcomes including improved health and safety...
October 2017: Applied Ergonomics
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