keyword
https://read.qxmd.com/read/38533503/unraveling-the-causal-role-of-immune-cells-in-gastrointestinal-tract-cancers-insights-from-a-mendelian-randomization-study
#21
JOURNAL ARTICLE
Yu-Xiang Wang, Chao-Ping Zhou, Da-Tian Wang, Jun Ma, Xue-Hu Sun, Yao Wang, Ya-Ming Zhang
BACKGROUND: Despite early attempts, the relationship between immune characteristics and gastrointestinal tract cancers remains incompletely elucidated. Hence, rigorous and further investigations in this domain hold significant clinical relevance for the development of novel potential immunotherapeutic targets. METHODS: We conducted a two-sample Mendelian randomization (MR) analysis using the tools available in the "TwoSampleMR" R package. The GWAS data for these 731 immune traits were sourced from the GWAS Catalog database...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38533418/association-between-spo-2-and-the-risk-of-death-in-elderly-t2dm-patients-with-cerebral-infarction-a-retrospective-cohort-study
#22
JOURNAL ARTICLE
Shuo Zhang, Jiaqi Ji, Siqi Gao, Shu Yang, Zeyi Song, Jianmin Li, Junjie Liu
OBJECTIVE: This study aimed to evaluate the SpO2 (transcutaneous oxygen saturation) -mortality link in elderly T2DM (diabetes mellitus type 2) patients with cerebral infarction and identify their optimal SpO2 range. METHODS: In this investigation, we employed a comprehensive approach. Initially, we screened the MIMIC-IV database, identifying elderly T2DM patients with cerebral infarction, utilizing specific ICD-9 and ICD-10 codes. We then harnessed the power of restricted cubic splines to craft a visual representation of the correlation between SpO2 and 1-year mortality...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38533321/decoding-the-rejection-code-understanding-why-articles-get-axed
#23
EDITORIAL
Vishal V Bhende, Tanishq S Sharma, Mathangi Krishnakumar, Anikode Subramanian Ramaswamy, Kanchan Bilgi, Saptak P Mankad
In the competitive arena of medical publishing, manuscript rejection remains a significant barrier to disseminating research findings. This editorial delves into the multifaceted nature of manuscript rejection, elucidating common reasons and proposing actionable strategies for authors to enhance their chances of acceptance. Key rejection factors include a mismatch with journal scope, lack of novelty, methodological flaws, inconclusive results, ethical issues, poor presentation, data inaccessibility, author misconduct, and plagiarism...
March 2024: Curēus
https://read.qxmd.com/read/38533122/dataset-representing-growth-performance-nutritional-assay-and-biochemical-profile-of-oscillatoria-spp
#24
JOURNAL ARTICLE
Jannatul Nayeem, Proma Dey, Sumit Kanti Dey, Rezaul Karim, Mohammed Ayoun, Abed Hasan Tuser, Nusrat Zaman Zemi, Helena Khatoon
Cyanobacteria are regarded as vital constituents of aquatic ecosystems which recently become viable option for bioremediation since it can remove contaminants from polluted water. They possess intriguing metabolic properties and exhibit differential growth patterns. This study elucidates the isolation and identification of two marine and two freshwater indigenous Oscillatoria spp., their growth performance, nutritional composition along with intricate biochemical profiles. Agar streak plate method was used for the isolation, growth curve was determined through chlorophyll content and optical density...
April 2024: Data in Brief
https://read.qxmd.com/read/38533042/enhancing-creative-cognition-through-project-based-learning-an-in-depth-scholarly-exploration
#25
REVIEW
Hao Yu
This study rigorously examines Project-Based Learning's (PBL) efficacy in augmenting creative thinking within educational frameworks. It investigates PBL's alignment with psychological tenets and cognitive processes to bolster creative capacities. Employing an extensive literature review, the research scrutinizes PBL's psychological and educational merits, project design, student engagement, cognitive growth, and the amalgamation of intellectual and affective elements. Findings reveal PBL's adaptability to cognitive rhythms, its role in amplifying information intake and motivation, and its enhancement of cognitive engagement and dynamic thought application...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38532952/data-management-in-multicountry-consortium-studies-the-enterics-for-global-health-efgh-shigella-surveillance-study-example
#26
JOURNAL ARTICLE
Erika Feutz, Prasanta K Biswas, Latif Ndeketa, Billy Ogwel, Uma Onwuchekwa, Golam Sarwar, Shazia Sultana, Pablo Peñataro Yori, Alyssa Acebedo, Naveed Ahmed, Imran Ahmed, Hannah E Atlas, Alex O Awuor, Md Amirul Islam Bhuiyan, Bakary Conteh, Oualy Diawara, Sarah Elwood, Moussa Fane, Md Ismail Hossen, Mahzabeen Ireen, Abdoulie F Jallow, Mehrab Karim, Margaret N Kosek, Karen L Kotloff, Clement Lefu, Jie Liu, Rebecca Maguire, Farah Naz Qamar, Maureen Ndalama, John Benjamin Ochieng, Caleb Okonji, Loyda Fiorella Zegarra Paredes, Patricia B Pavlinac, Karin Perez, Sonia Qureshi, Francesca Schiaffino, Moussa Traore, Kirkby D Tickell, Richard Wachepa, Desiree Witte, Jennifer Cornick, M Jahangir Hossain, Farhana Khanam, Maribel Paredes Olortegui, Richard Omore, Samba O Sow, Mohammad Tahir Yousafzai, Sean R Galagan
BACKGROUND: Rigorous data management systems and planning are essential to successful research projects, especially for large, multicountry consortium studies involving partnerships across multiple institutions. Here we describe the development and implementation of data management systems and procedures for the Enterics For Global Health (EFGH) Shigella surveillance study-a 7-country diarrhea surveillance study that will conduct facility-based surveillance concurrent with population-based enumeration and a health care utilization survey to estimate the incidence of Shigella- -associated diarrhea in children 6 to 35 months old...
March 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38532487/medicinal-plants-and-natural-products-for-treating-overactive-bladder
#27
REVIEW
Huanxian Chen, Maggie Pui Man Hoi, Simon Ming Yuen Lee
BACKGROUND: Overactive bladder (OAB) presents a high prevalence of 16-18% worldwide. The pathophysiology of OAB is still poorly understood while effective therapy or countermeasure are very limited. On the other hand, medicinal plants and herbal remedies have been utilized for treating lower urinary tract symptoms (LUTS) in both Eastern and Western cultures since ancient times. In recent years, accumulating progress has also been made in OAB treatment research by using medicinal plants...
March 27, 2024: Chinese Medicine
https://read.qxmd.com/read/38532396/retinal-injury-from-a-laser-skin-resurfacing-device-during-medical-tourism-a-public-health-concern
#28
JOURNAL ARTICLE
Lester H Lambert, Brett L Tompkins, Ian C Uber, Kapil G Kapoor, David J Ramsey
BACKGROUND: Laser skin resurfacing is a popular cosmetic procedure for noninvasive skin rejuvenation. Since health insurance plans often do not cover these types of procedures, patients often pay out of pocket. Consequently, there is an incentive to go abroad, where prices are more affordable. However, practitioners in destination countries may lack rigorous training on laser safety, regulatory oversight, or licensing, especially on devices used for "cosmetic" procedures. In certain cases, this can lead to tragic outcomes, especially when underqualified practitioners operate medical-grade laser devices...
March 26, 2024: BMC Ophthalmology
https://read.qxmd.com/read/38532119/comparison-of-attribute-based-encryption-schemes-in-securing-healthcare-systems
#29
JOURNAL ARTICLE
Redwan Walid, Karuna Pande Joshi, Seung Geol Choi
E-health has become a top priority for healthcare organizations focused on advancing healthcare services. Thus, medical organizations have been widely adopting cloud services, resulting in the effective storage of sensitive data. To prevent privacy and security issues associated with the data, attribute-based encryption (ABE) has been a popular choice for encrypting private data. Likewise, the attribute-based access control (ABAC) technique has been widely adopted for controlling data access. Researchers have proposed electronic health record (EHR) systems using ABE techniques like ciphertext policy attribute-based encryption (CP-ABE), key policy attribute-based encryption (KP-ABE), and multi authority attribute-based encryption (MA-ABE)...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531952/the-clinician-ai-interface-intended-use-and-explainability-in-fda-cleared-ai-devices-for-medical-image-interpretation
#30
JOURNAL ARTICLE
Stephanie L McNamara, Paul H Yi, William Lotter
As applications of AI in medicine continue to expand, there is an increasing focus on integration into clinical practice. An underappreciated aspect of this clinical translation is where the AI fits into the clinical workflow, and in turn, the outputs generated by the AI to facilitate clinician interaction in this workflow. For instance, in the canonical use case of AI for medical image interpretation, the AI could prioritize cases before clinician review or even autonomously interpret the images without clinician review...
March 26, 2024: NPJ Digital Medicine
https://read.qxmd.com/read/38531680/multimodal-learning-for-temporal-relation-extraction-in-clinical-texts
#31
JOURNAL ARTICLE
Timotej Knez, Slavko Žitnik
OBJECTIVES: This study focuses on refining temporal relation extraction within medical documents by introducing an innovative bimodal architecture. The overarching goal is to enhance our understanding of narrative processes in the medical domain, particularly through the analysis of extensive reports and notes concerning patient experiences. MATERIALS AND METHODS: Our approach involves the development of a bimodal architecture that seamlessly integrates information from both text documents and knowledge graphs...
March 26, 2024: Journal of the American Medical Informatics Association: JAMIA
https://read.qxmd.com/read/38531679/perspectives-on-the-role-of-industry-in-informatics-research-and-authorship
#32
JOURNAL ARTICLE
Howard R Strasberg, Gretchen Purcell Jackson, Suzanne R Bakken, Aziz Boxwala, Joshua E Richardson, Jon D Morrow
OBJECTIVES: Advances in informatics research come from academic, nonprofit, and for-profit industry organizations, and from academic-industry partnerships. While scientific studies of commercial products may offer critical lessons for the field, manuscripts authored by industry scientists are sometimes categorically rejected. We review historical context, community perceptions, and guidelines on informatics authorship. PROCESS: We convened an expert panel at the American Medical Informatics Association 2022 Annual Symposium to explore the role of industry in informatics research and authorship with community input...
March 26, 2024: Journal of the American Medical Informatics Association: JAMIA
https://read.qxmd.com/read/38531581/behavioural-mental-health-interventions-delivered-in-the-emergency-department-for-suicide-overdose-and-psychosis-a-scoping-review
#33
JOURNAL ARTICLE
Shannon M Nugent, Johanna Anderson, Sarah K Young
OBJECTIVE: To identify and describe evidence on brief emergency department (ED)-delivered behavioural and care process interventions among patients presenting with suicide attempt or acute ideation, substance overdose or psychosis. DESIGN: We employed a scoping review design and searched multiple data sources, clinical trial registries and references lists through March 2023. We included English-language trials and rigorously designed observational studies. In alignment with scoping review guidelines, we did not assess the quality of included studies or rate the strength of evidence of intervention effectiveness...
March 25, 2024: BMJ Open
https://read.qxmd.com/read/38531569/efficacy-and-safety-of-traditional-chinese-manual-therapy-tuina-in-patients-with-non-specific-chronic-low-back-pain-a-study-protocol-for-a-randomised-controlled-trial
#34
JOURNAL ARTICLE
Ben Cao, Sitong Fang, Zhiwei Wu, Xin Zhou, Lingjun Kong, Qingguang Zhu, Bowen Zhu, Cheng Tang, Min Fang
INTRODUCTION: Non-pharmacological interventions play a crucial role in the management of non-specific chronic low back pain (NSCLBP). One prime example is Tuina, a traditional Chinese manual therapy that incorporates pressing, kneading and rubbing techniques to alleviate physical discomfort and enhance overall well-being. It serves as a widely used technique in China and other East Asian countries. However, the effectiveness and safety of Tuina for managing NSCLBP have not been substantiated through rigorous clinical research...
March 25, 2024: BMJ Open
https://read.qxmd.com/read/38531327/delivery-room-resuscitation-of-infants-with-congenital-diaphragmatic-hernia-lessons-learned-through-video-review
#35
JOURNAL ARTICLE
K Taylor Wild, Natalie Rintoul, Holly L Hedrick, Lauren Heimall, Leane Soorikian, Elizabeth E Foglia, Anne M Ades, Heidi M Herrick
INTRODUCTION: Delivery room (DR) interventions for infants with congenital diaphragmatic hernia (CDH) are not well described. This study sought to describe timing and order of DR interventions and identify system factors impacting CDH DR resuscitations using a human factors framework. METHODS: Single center observational study of video recorded CDH DR resuscitations documenting timing and order of interventions. The team used the Systems Engineering Initiative for Patient Safety (SEIPS) model to identify system factors impacting DR resuscitations and time to invasive ventilation...
March 26, 2024: Fetal Diagnosis and Therapy
https://read.qxmd.com/read/38531228/mobilizing-data-during-a-crisis-building-rapid-evidence-pipelines-using-multi-institutional-real-world-data
#36
JOURNAL ARTICLE
Jayson S Marwaha, Maren Downing, John Halamka, Amy Abernethy, Joseph B Franklin, Brian Anderson, Isaac Kohane, Kavishwar Wagholikar, John Brownstein, Melissa Haendel, Gabriel A Brat
The COVID-19 pandemic generated tremendous interest in using real world data (RWD). Many consortia across the public and private sectors formed in 2020 with the goal of rapidly producing high-quality evidence from RWD to guide medical decision-making, public health priorities, and more. Experiences were gathered from five large consortia on rapid multi-institutional evidence generation during the COVID-19 pandemic. Insights have been compiled across five dimensions: consortium composition, governance structure and alignment of priorities, data sharing, data analysis, and evidence dissemination...
March 25, 2024: Healthcare
https://read.qxmd.com/read/38531165/enigma-s-simple-seven-recommendations-to-enhance-the-reproducibility-of-resting-state-fmri-in-traumatic-brain-injury
#37
REVIEW
Karen Caeyenberghs, Phoebe Imms, Andrei Irimia, Martin M Monti, Carrie Esopenko, Nicola L de Souza, Juan F Dominguez D, Mary R Newsome, Ekaterina Dobryakova, Andrew Cwiek, Hollie A C Mullin, Nicholas J Kim, Andrew R Mayer, Maheen M Adamson, Kevin Bickart, Katherine M Breedlove, Emily L Dennis, Seth G Disner, Courtney Haswell, Cooper B Hodges, Kristen R Hoskinson, Paula K Johnson, Marsh Königs, Lucia M Li, Spencer W Liebel, Abigail Livny, Rajendra A Morey, Alexandra M Muir, Alexander Olsen, Adeel Razi, Matthew Su, David F Tate, Carmen Velez, Elisabeth A Wilde, Brandon A Zielinski, Paul M Thompson, Frank G Hillary
Resting state functional magnetic resonance imaging (rsfMRI) provides researchers and clinicians with a powerful tool to examine functional connectivity across large-scale brain networks, with ever-increasing applications to the study of neurological disorders, such as traumatic brain injury (TBI). While rsfMRI holds unparalleled promise in systems neurosciences, its acquisition and analytical methodology across research groups is variable, resulting in a literature that is challenging to integrate and interpret...
March 5, 2024: NeuroImage: Clinical
https://read.qxmd.com/read/38530970/development-of-certified-reference-material-solutions-for-phytochemicals-in-ginger-and-kava
#38
JOURNAL ARTICLE
Sarah M Aijaz, Zoe Ruan, Christopher Leija, Lauren A Lytwak, Shelby Waddell, Adam J Kuszak, Stephen A Wise, Uma Sreenivasan
BACKGROUND: Dietary supplements derived from botanicals are commonly consumed and investigated in biomedical studies for their potential health benefits. Accurate identification and quantification of key chemical constituents from botanical ingredients is necessary for consistent product preparations and reproducible research results. Manufacturers need quantitative reference materials of the chemical constituents of interest to verify the content of ingredients and products. The rigor and reproducibility of biomedical research is enhanced through thorough characterization of the interventions used in mechanistic, clinical, and safety investigations...
March 26, 2024: Journal of AOAC International
https://read.qxmd.com/read/38530721/music-accelerated-convergence-for-distributed-optimization-with-inexact-and-exact-methods
#39
JOURNAL ARTICLE
Mou Wu, Haibin Liao, Zhengtao Ding, Yonggang Xiao
Gradient-type distributed optimization methods have blossomed into one of the most important tools for solving a minimization learning task over a networked agent system. However, only one gradient update per iteration makes it difficult to achieve a substantive acceleration of convergence. In this article, we propose an accelerated framework named multiupdates single-combination (MUSIC) allowing each agent to perform multiple local updates and a single combination in each iteration. More importantly, we equip inexact and exact distributed optimization methods into this framework, thereby developing two new algorithms that exhibit accelerated linear convergence and high communication efficiency...
March 26, 2024: IEEE Transactions on Neural Networks and Learning Systems
https://read.qxmd.com/read/38530598/challenges-in-obtaining-and-seeking-information-among-breast-cancer-survivors-in-an-asian-country-a-qualitative-study
#40
JOURNAL ARTICLE
Izzati Yussof, Noraida Mohamed Shah, Nur Fa'izah Ab Muin, Sarahfarina Abd Rahim, Ernieda Hatah, Nor Asyikin Mohd Tahir, Kavinash Loganathan, Murallitharan Munisamy
Breast cancer survivors on adjuvant endocrine therapy (AET) have distinct information-seeking experience compared to those in the diagnosis and intensive treatment phase. This study aimed to understand the challenges in obtaining and seeking information among Malaysian breast cancer survivors. We conducted semi-structured, one-to-one interviews among patients using AET from two hospitals and a local cancer organization. Interviews were conducted until theme saturation was achieved (N = 25). Interviews were de-identified, transcribed verbatim, and analysed using thematic analysis...
March 26, 2024: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
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