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https://www.readbyqxmd.com/read/28088668/near-infrared-light-triggered-drug-delivery-system-for-higher-efficacy-of-combined-chemo-photothermal-treatment
#1
Yi Chen, Haohuan Li, Yueyang Deng, Haifeng Sun, Xue Ke, Tianyuan Ci
: The combination of chemotherapy and photothermal therapy is a promising strategy for cancer treatment. In the present study, indocyanine green (ICG), a widely used near-infrared (NIR) dye in photothermal therapy, and chemotherapeutic drug-doxorubicin (DOX) were loaded within the nanoparticles of novel designed arylboronic ester and cholesterol modified hyaluronic acid (PPE-Chol1-HA), denoted as PCH-DI. We take advantage of reactive oxygen species (ROS) production capability of ICG and ROS-sensitivity of arylboronic ester to realize controllable drug release...
January 11, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28079280/cryptosporidiosis-outbreak-at-an-academic-animal-research-laboratory-colorado-2014
#2
Jessica Hancock-Allen, Nisha B Alden, Alicia B Cronquist
BACKGROUND: After cryptosporidiosis was reported in three workers caring for preweaned calves at an academic research laboratory, we sought to identify cases, determine risk factors, and implement control measures. METHODS: A cryptosporidiosis case was defined as diarrhea duration ≥72 hr, abdominal cramps, or vomiting in an animal research laboratory worker during July 14-July 31. A confirmed case had laboratory evidence of Cryptosporidium infection. Staff were interviewed regarding illness, potential exposures, training, and personal protective equipment (PPE) standard operating procedures (SOPs)...
February 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/28071726/the-ppe2-protein-of-mycobacterium-tuberculosis-translocates-to-host-nucleus-and-inhibits-nitric-oxide-production
#3
Khalid Hussain Bhat, Shruti Srivastava, Sandeep Kumar Kotturu, Sudip Ghosh, Sangita Mukhopadhyay
Mycobacterium tuberculosis, the bacterium that causes tuberculosis, is one of the most successful pathogens of humans. It has evolved several adaptive skills and evasion mechanisms to hijack the immunologically educated host to suit its intracellular lifestyle. Here, we show that one of the unique PPE family member proteins of M. tuberculosis, PPE2, can limit nitric oxide (NO) production by inhibiting inos gene transcription. PPE2 protein has a leucine zipper DNA-binding motif and a functional nuclear localization signal...
January 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28069154/the-assessment-and-management-of-chemotherapy-related-toxicities-in-patients-with-breast-cancer-colorectal-cancer-and-hodgkin-s-and-non-hodgkin-s-lymphomas-a-scoping-review
#4
Patricia Fox, Andrew Darley, Eileen Furlong, Christine Miaskowski, Elisabeth Patiraki, Jo Armes, Emma Ream, Constantina Papadopoulou, Lisa McCann, Nora Kearney, Roma Maguire
PURPOSE: The purpose of the eSMART (Electronic Symptom Management using the Advanced Symptom Management System (ASyMS) Remote Technology) study is to evaluate the use of mobile phone technology to manage chemotherapy-related toxicities (CRTs) in people with breast cancer (BC), colorectal cancer (CRC), Hodgkin's lymphoma (HL), and non-Hodgkin lymphoma (NHL)) across multiple European sites. One key objective was to review the published and grey literature on assessment and management of CRTs among patients receiving primary chemotherapy for BC, CRC, HL, and NHL to ensure that ASyMS remained evidence-based and reflected current and local practice...
February 2017: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/28067030/personal-protective-equipment-use-and-hazardous-drug-spills-among-ambulatory-oncology-nurses
#5
Bei He, Kari Mendelsohn-Victor, Marjorie McCullagh, Christopher Friese
Purpose/Objectives: To examine patterns and organizational correlates of personal protective equipment (PPE) use and hazardous drug spills. Design: Cross-sectional mailed survey. Setting: Ambulatory practices in California, Georgia, and Michigan. Sample: 252 Oncology Nursing Society members who administer hazardous drugs. Methods: Bivariate and multivariable regression analyses. Main Research Variables: Outcomes were PPE use and hazardous drug spills...
6, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28065328/use-of-personal-protective-equipment-among-health-care-personnel-results-of-clinical-observations-and-simulations
#6
JaHyun Kang, John M O'Donnell, Bonnie Colaianne, Nicholas Bircher, Dianxu Ren, Kenneth J Smith
BACKGROUND: Very little is known about how health care personnel (HCP) actually use personal protective equipment (PPE). METHODS: The clinical PPE practices of 50 HCP from selected units at the University of Pittsburgh Medical Center (UPMC) Presbyterian Hospital were videotaped with HCP consent. For 2 PPE simulation sessions (simple and full-body sets), 82 HCP were recruited throughout the UPMC system. Simulation practices were videotaped and examined using fluorescent powder with ultraviolet lighting...
January 1, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28051292/truxene-based-hyperbranched-conjugated-polymers-fluorescent-micelles-detect-explosives-in-water
#7
Wei Huang, Emanuel Smarsly, Jinsong Han, Markus Bender, Kai Seehafer, Irene Wacker, Rasmus R Schroeder, Uwe H F Bunz
We report two hyperbranched conjugated polymers (HCP) with truxene units as core and 1,4-didodecyl-2,5-diethynylbenzene as well as 1,4-bis(dodecyloxy)-2,5-diethynyl¬benzene as co-monomers. Two analogous poly(para-phenylene¬ethynylene)s (PPE) are also prepared as comparison to demonstrate the difference between the truxene and the phenyl moieties in their optical properties and their sensing performance. The four polymers are tested for nitroaromatic analytes and display different fluorescence quenching responses...
January 4, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28047614/su-f-p-38-professional-practice-evaluation-and-quality-improvement
#8
J Rong
PURPOSE: In 2008, The Joint Commission (JC) implemented a standard mandating clearly defined quality improvement metrics to be factored into the evaluation of medical practitioners' professional performance as part of the process of granting and maintaining medical staff privileges in a hospital. Specifically, there are two processes for a credentialed medical staff member to go through: Ongoing Professional Practice Evaluation (OPPE) and Focused Professional Practice Evaluation (FPPE)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28043631/the-first-population-structure-and-comparative-genomics-analysis-of-mycobacterium-africanum-strains-from-ghana-reveals-higher-diversity-of-lineage-5
#9
Isaac D Otchere, Simon R Harris, Sanches L Busso, Adwoa Asante-Poku, Stephen Osei-Wusu, Kwadwo Koram, Julian Parkhill, Sebastien Gagneux, Dorothy Yeboah-Manu
OBJECTIVE/BACKGROUND: Mycobacterium africanum (MAF) remains an important TB causing pathogen in West Africa; however, little is known about its population structure and actual diversity which may have implications for diagnostics and vaccines. We carried out comparative genomics analysis of candidate Mycobacterium tuberculosis (MTB) and MAF using whole genome sequencing. METHODS: Clinical MTB complex strains (n=187) comprising L4 (n=22), L5 (n=126), and L6 (n=39) isolated over 8years from Ghana were whole genome sequenced...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28010906/zoonotic-disease-risk-perceptions-in-the-british-veterinary-profession
#10
Charlotte Robin, Judy Bettridge, Fiona McMaster
In human and veterinary medicine, reducing the risk of occupationally-acquired infections relies on effective infection prevention and control practices (IPCs). In veterinary medicine, zoonoses present a risk to practitioners, yet little is known about how these risks are understood and how this translates into health protective behaviour. This study aimed to explore risk perceptions within the British veterinary profession and identify motivators and barriers to compliance with IPCs. A cross-sectional study was conducted using veterinary practices registered with the Royal College of Veterinary Surgeons...
January 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28005780/morphological-patterns-and-variations-of-the-nasal-septum-components-and-their-clinical-implications
#11
Mi-Sun Hur, Hyung-Sun Won, Dai-Soon Kwak, In-Hyuk Chung, In-Beom Kim
The aim of this study was to clarify the morphological patterns and proportions of the components of the nasal septum. Anatomical examinations were performed on 70 nasal septums of embalmed Korean adult cadavers. The septal deviation was checked before cutting the nasal cavity midsagittally with the aid of a laryngoscope. The shape of each component of the nasal septum was identified, and photographs were taken from a midline sagittal view. A line was drawn on each photograph between the septal components, and then the area of each septal component was measured using software...
November 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27992105/cyclobutanone-analogues-of-%C3%AE-lactam-antibiotics-%C3%AE-lactamase-inhibitors-with-untapped-potential
#12
Prarthana Devi, Peter J Rutledge
β-Lactam antibiotics have been used for many years to treat bacterial infections. However the effective treatment of an increasing range of microbial infections is threatened by bacterial resistance to β-lactams: the prolonged, widespread and at times reckless use of these drugs has spawned widespread resistance, which renders them ineffective against many bacterial strains. The cyclobutanone ring system is isosteric with β-lactam: in cyclobutanone analogues, the eponymous cyclic amide is replaced with an all-carbon ring, the amide N substituted by a tertiary C-H α to a ketone...
December 19, 2016: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/27991608/testing-an-intervention-to-decrease-healthcare-workers-exposure-to-antineoplastic-agents
#13
Catherine Graeve, Patricia M McGovern, Susan Arnold, Martha Polovich
PURPOSE/OBJECTIVES: To develop and test a worksite intervention that protects healthcare workers who handle antineoplastic drugs from work-related exposures. 
. DESIGN: Intervention study. 
. SETTING: A university hospital in a large midwestern metropolitan area and its outpatient chemotherapy infusion clinic.
. SAMPLE: 163 staff (nurses, pharmacists, and pharmacy technicians) who work with antineoplastic agents...
January 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/27987050/mycobacterium-tuberculosis-pe_pgrs18-enhances-the-intracellular-survival-of-m-smegmatis-via-altering-host-macrophage-cytokine-profiling-and-attenuating-the-cell-apoptosis
#14
Wenmin Yang, Wanyan Deng, Jie Zeng, Sai Ren, Md Kaisar Ali, Yinzhong Gu, Yangyuling Li, Jianping Xie
Mycobacterium tuberculosis PE/PPE family proteins, named after the presence of conserved PE (Pro-Glu) and PPE (Pro-Pro-Glu) domains at N-terminal, are prevalent in M. tuberculosis genome. The function of most PE/PPE family proteins remains elusive. To characterize the function of PE_PGRS18, the encoding gene was heterologously expressed in M. smegmatis, a nonpathogenic mycobacterium. The recombinant PE_PGRS18 is cell wall associated. M. smegmatis PE_PGRS18 recombinant showed differential response to stresses and altered the production of host cytokines IL-6, IL-1β, IL-12p40 and IL-10, as well as enhanced survival within macrophages largely via attenuating the apoptosis of macrophages...
December 16, 2016: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/27925149/behavioural-interventions-to-promote-workers-use-of-respiratory-protective-equipment
#15
REVIEW
Bao Yen Luong Thanh, Malinee Laopaiboon, David Koh, Pornpun Sakunkoo, Hla Moe
BACKGROUND: Respiratory hazards are common in the workplace. Depending on the hazard and exposure, the health consequences may include: mild to life-threatening illnesses from infectious agents, acute effects ranging from respiratory irritation to chronic lung conditions, or even cancer from exposure to chemicals or toxins. Use of respiratory protective equipment (RPE) is an important preventive measure in many occupational settings. RPE only offers protection when worn properly, when removed safely and when it is either replaced or maintained regularly...
7, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27924234/a-descriptive-study-of-occupational-health-services-in-self-employed-enterprises-nanoscale-enterprises-shiraz-iran
#16
Mehdi Jahangiri, Akbar Rostamabadi, Parvaneh Yekzamani, Bahare Mahmood Abadi, Fariborz Behbood, Seyyedeh Fatemeh Ahmadi, Zahra Momeni
BACKGROUND: This study was conducted with aim of providing an overview of the current status of occupational health services and identifying the most common harmful agents at workplaces of Iranian self-employed enterprises (Nano-Scale Enterprises). METHODS: A cross-sectional study was performed among a random sample including 1,758 employees engaging in self-employed enterprises with 5 and less employees. RESULTS: Coverage of occupational health surveillance was very poor, annual health examinations were been conducted only for 64 (3...
December 2016: Safety and Health At Work
https://www.readbyqxmd.com/read/27923496/neural-correlates-of-rdoc-reward-constructs-in-adolescents-with-diverse-psychiatric-symptoms-a-reward-flanker-task-pilot-study
#17
Kailyn A L Bradley, Julia A C Case, Rachel D Freed, Emily R Stern, Vilma Gabbay
BACKGROUND: There has been growing interest under the Research Domain Criteria initiative to investigate behavioral constructs and their underlying neural circuitry. Abnormalities in reward processes are salient across psychiatric conditions and may precede future psychopathology in youth. However, the neural circuitry underlying such deficits has not been well defined. Therefore, in this pilot, we studied youth with diverse psychiatric symptoms and examined the neural underpinnings of reward anticipation, attainment, and positive prediction error (PPE, unexpected reward gain)...
December 1, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27920823/antioxidant-effects-of-hydroalcoholic-and-polyphenolic-extracts-of-peucedanum-pastinacifolium-boiss-hausskn
#18
Ahmad Movahedian, Behzad Zolfaghari, Mehrzad Mirshekari
Antioxidant activity of Peucedanum pastinacifolium Boiss. & Hausskn aerial part hydroalcoholic extract (HAE) and polyphenolic extract (PPE) as well as their total phenolic and flavonoid contents were studied. Phenolic and flavonoid contents were respectively estimated as gallic acid and quercetin equivalents. The in vitro antioxidant activity of two extracts of P. pastinacifolium were evaluated by radical scavenging of 1,1-diphenyl-2-picryl hydrazyl radical (DPPH), chelating activity on ferrous ions, or ferric reducing antioxidant power (FRAP) assay...
October 2016: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27908761/discovery-of-dual-positive-allosteric-modulators-pams-of-the-metabotropic-glutamate-2-receptor-and-cyslt1-antagonists-for-treating-migraine-headache
#19
Maria-Jesus Blanco, Dana R Benesh, James A Knobelsdorf, Albert Khilevich, Guillermo S Cortez, Fese Mokube, Thomas D Aicher, Todd M Groendyke, Fredrik P Marmsater, Tony P Tang, Kirk W Johnson, Amy Clemens-Smith, Mark A Muhlhauser, Steven Swanson, John Catlow, Renee Emkey, Michael P Johnson, Jeffrey M Schkeryantz
Pyridylmethylsulfonamide series were the first reported example of positive allosteric modulators (PAM) of the mGlu2 receptor. The hydroxyacetophenone scaffold is a second series of mGlu2 PAMs we have identified. This series of molecules are potent mGlu2 potentiators and possess significant CysLT1 (cysteinyl leukotriene receptor 1) antagonist activity, showing in vivo efficacy in a dural plasma protein extravasation (PPE) model of migraine. In this paper, we describe the dual SAR, pharmacokinetics and preclinical in vivo efficacy data for a tetrazole containing hydroxyacetophenone scaffold...
January 15, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27903757/beyond-hand-hygiene-a-qualitative-study-of-the-everyday-work-of-preventing-cross-contamination-on-hospital-wards
#20
Su-Yin Hor, Claire Hooker, Rick Iedema, Mary Wyer, Gwendolyn L Gilbert, Christine Jorm, Matthew Vincent Neil O'Sullivan
BACKGROUND: Hospital-acquired infections are the most common adverse event for inpatients worldwide. Efforts to prevent microbial cross-contamination currently focus on hand hygiene and use of personal protective equipment (PPE), with variable success. Better understanding is needed of infection prevention and control (IPC) in routine clinical practice. METHODS: We report on an interventionist video-reflexive ethnography study that explored how healthcare workers performed IPC in three wards in two hospitals in New South Wales, Australia: an intensive care unit and two general surgical wards...
November 30, 2016: BMJ Quality & Safety
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