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https://www.readbyqxmd.com/read/27920823/antioxidant-effects-of-hydroalcoholic-and-polyphenolic-extracts-of-peucedanum-pastinacifolium-boiss-hausskn
#1
Ahmad Movahedian, Behzad Zolfaghari, Mehrzad Mirshekari
Antioxidant activity of Peucedanum pastinacifolium Boiss. & Hausskn aerial part hydroalcoholic extract (HAE) and polyphenolic extract (PPE) as well as their total phenolic and flavonoid contents were studied. Phenolic and flavonoid contents were respectively estimated as gallic acid and quercetin equivalents. The in vitro antioxidant activity of two extracts of P. pastinacifolium were evaluated by radical scavenging of 1,1-diphenyl-2-picryl hydrazyl radical (DPPH), chelating activity on ferrous ions, or ferric reducing antioxidant power (FRAP) assay...
October 2016: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27908761/discovery-of-dual-positive-allosteric-modulators-pams-of-the-metabotropic-glutamate-2-receptor-and-cyslt1-antagonists-for-treating-migraine-headache
#2
Maria-Jesus Blanco, Dana R Benesh, James A Knobelsdorf, Albert Khilevich, Guillermo S Cortez, Fese Mokube, Thomas D Aicher, Todd M Groendyke, Fredrik P Marmsater, Tony P Tang, Kirk W Johnson, Amy Clemens-Smith, Mark A Muhlhauser, Steven Swanson, John Catlow, Renee Emkey, Michael P Johnson, Jeffrey M Schkeryantz
Pyridylmethylsulfonamide series were the first reported example of positive allosteric modulators (PAM) of the mGlu2 receptor. The hydroxyacetophenone scaffold is a second series of mGlu2 PAMs we have identified. This series of molecules are potent mGlu2 potentiators and possess significant CysLT1 (cysteinyl leukotriene receptor 1) antagonist activity, showing in vivo efficacy in a dural plasma protein extravasation (PPE) model of migraine. In this paper, we describe the dual SAR, pharmacokinetics and preclinical in vivo efficacy data for a tetrazole containing hydroxyacetophenone scaffold...
November 18, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27903757/beyond-hand-hygiene-a-qualitative-study-of-the-everyday-work-of-preventing-cross-contamination-on-hospital-wards
#3
Su-Yin Hor, Claire Hooker, Rick Iedema, Mary Wyer, Gwendolyn L Gilbert, Christine Jorm, Matthew Vincent Neil O'Sullivan
BACKGROUND: Hospital-acquired infections are the most common adverse event for inpatients worldwide. Efforts to prevent microbial cross-contamination currently focus on hand hygiene and use of personal protective equipment (PPE), with variable success. Better understanding is needed of infection prevention and control (IPC) in routine clinical practice. METHODS: We report on an interventionist video-reflexive ethnography study that explored how healthcare workers performed IPC in three wards in two hospitals in New South Wales, Australia: an intensive care unit and two general surgical wards...
November 30, 2016: BMJ Quality & Safety
https://www.readbyqxmd.com/read/27898253/establishing-equipoise-national-survey-of-the-treatment-of-pediatric-para-pneumonic-effusion-and-empyema
#4
Morgan K Richards, Jarod P Mcateer, Todd C Edwards, Lucas R Hoffman, Matthew P Kronman, Dennis W Shaw, Adam B Goldin
BACKGROUND: Despite six randomized trials of various treatments for pediatric para-pneumonic effusion (PPE), management approaches differ. The purpose of this study was to gain insight into opinions on PPE treatment with the goal of designing a definitive trial to generate consensus intervention guidelines. METHODS: To evaluate physician opinions regarding PPE management, we developed a survey based on input from a nationwide, multi-disciplinary advisory group that established content validity...
November 29, 2016: Surgical Infections
https://www.readbyqxmd.com/read/27894184/australian-medical-students-have-fewer-opportunities-to-do-physical-examination-of-peers-of-the-opposite-gender
#5
Silas Taylor, Boaz Shulruf
PURPOSE: Peer physical examination (PPE), by which junior medical students learn physical examination skills before practicing on patients, is a widely implemented and accepted part of medical curricula. However, the ethical implications of PPE have been debated, since issues including student gender impact on its acceptability. Research has previously demonstrated the phenomenon of 'attitude-behavior inconsistency' showing that students' predictions about their participation in PPE differ from what they actually do in practice...
2016: Journal of Educational Evaluation for Health Professions
https://www.readbyqxmd.com/read/27890031/a-national-assessment-of-the-health-and-safety-of-emergency-medical-services-professionals
#6
Melissa A Bentley, Roger Levine
OBJECTIVES: The objectives were to assess changes in (1) health and physical fitness, (2) the prevalence of selected health problems, (3) risk behaviors, (4) ambulance safety issues, and (5) the preparedness of Emergency Medical Services (EMS) professionals. In addition, the incidence of patient-initiated violence directed toward EMS personnel and associated factors were assessed. METHODS: Data were obtained from a sample of nationally certified EMS professionals via annual questionnaires between 1999 and 2008...
November 28, 2016: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/27885779/explaining-the-cyclic-voltammetry-of-a-poly-1-4-phenylene-ethynylene-alt-poly-1-4-phenylene-vinylene-copolymer-upon-oxidation-by-using-spectroscopic-techniques
#7
Christina Enengl, Sandra Enengl, Nassima Bouguerra, Marek Havlicek, Helmut Neugebauer, Daniel A M Egbe
Poly(1,4-phenylene-ethynylene)-alt-poly(1,4-phenylene-vinylene) (PPE-PPV) copolymers have attracted quite a lot of attention in the last few years for electronic device applications owing to their enhanced fluorescence. In this work, we focus on one particular PPE-PPV copolymer with dissymmetrically substituted 1,4-phenylene-ethynylene and symmetrically substituted 1,4-phenylene-vinylene building units. Six successively performed cyclic voltammograms are presented, measured during the oxidation reactions. As the oxidation onset of the electrochemical reaction shifts to lower potentials in each cycle, this behavior is elucidated by using spectroscopic techniques ranging from UV/Vis/near-IR to mid-IR including spin-resonance techniques...
November 4, 2016: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/27885096/promoting-fluoroscopic-personal-radiation-protection-equipment-unfamiliarity-facts-and-fears
#8
Stephen Balter
An incomplete understanding of risk can cause inappropriate fear. Personal protective equipment (PPE) offered for the prevention of brain cancer in interventional fluoroscopists (IR-PPE). Similar items are offered for cell-phone use (RF-PPE). Publications on fluoroscopy staff brain cancer and similar papers on cell-phone induced brain cancer were reviewed. An internet safety product search was performed, which resulted in many tens of thousands of hits. Vendor claims for either ionizing radiation or radio frequency products seldom addressed the magnitude of the risk...
November 24, 2016: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/27875561/the-perception-of-physician-empathy-by-patients-with-inflammatory-bowel-disease
#9
Costanza Chiapponi, Maxie Witt, Gabriele E Dlugosch, Veit Gülberg, Matthias Siebeck
BACKGROUND AND AIMS: This study focused on the difference between perceived and desired physician empathy (pPE and dPE) in the eye of patients with inflammatory bowel disease (IBD). It was investigated if a discrepancy (ΔPE) correlates with trust and satisfaction of patients. At the same time the aim was to gain detailed information about the subjective burden of disease and the resources of IBD patients, in order to better understand them. METHODS: A modified version of the German Version of the Consultation and Relational Empathy (CARE) measure was completed as a paper-and-pencil questionnaire by IBD patients attending our facility (n = 32) and as an online survey by IBD patients at other locations throughout Germany (n = 89)...
2016: PloS One
https://www.readbyqxmd.com/read/27871099/evaluation-of-wiaman-technology-demonstrator-biofidelity-relative-to-sub-injurious-pmhs-response-in-simulated-under-body-blast-events
#10
Hollie A Pietsch, Kelly E Bosch, David R Weyland, E Meade Spratley, Kyvory A Henderson, Robert S Salzar, Terrance A Smith, Brandon M Sagara, Constantine K Demetropoulos, Christopher J Dooley, Andrew C Merkle
Three laboratory simulated sub-injurious under-body blast (UBB) test conditions were conducted with whole-body Post Mortem Human Surrogates (PMHS) and the Warrior Assessment Injury Manikin (WIAMan) Technology Demonstrator (TD) to establish and assess UBB biofidelity of the WIAMan TD. Test conditions included a rigid floor and rigid seat with independently varied pulses. On the floor, peak velocities of 4 m/s and 6 m/s were applied with a 5 ms time to peak (TTP). The seat peak velocity was 4 m/s with varied TTP of 5 and 10 ms...
November 2016: Stapp Car Crash Journal
https://www.readbyqxmd.com/read/27859892/discovery-of-the-type-vii-esx-1-secretion-needle
#11
Louis Ates, And Roland Brosch
Mycobacterium tuberculosis, the etiological agent of human tuberculosis harbours five ESAT-6/type VII secretion (ESX/T7S) systems. The first esx gene clusters were identified during the genome-sequencing project of M. tuberculosis H37Rv. Follow-up studies revealed additional genes playing important roles in ESX/T7S systems. Among the latter genes, one can find those that encode Pro-Glu (PE) and Pro-Pro-Glu (PPE) proteins as well as a gene cluster that is encoded > 260 kb upstream of the esx-1 locus and encodes ESX-1 secretion-associated proteins EspA (Rv3616c), EspC (Rv3615c) and EspD (Rv3614c)...
November 16, 2016: Molecular Microbiology
https://www.readbyqxmd.com/read/27859524/knowledge-attitudes-and-practices-for-respiratory-and-hearing-health-among-midwestern-farmers
#12
Mary E Cramer, Mary J Wendl, Harlan Sayles, Ellen Duysen, Chandran Achutan
OBJECTIVE: The purpose of this study was to assess knowledge, attitudes, and practices for hearing and respiratory health/safety among farmers in seven Midwestern states served by a federally funded Agricultural Center. Findings provided a baseline to longitudinally track the Agricultural Center's program outcomes and to design community education to improve safety and health among farmers. DESIGN AND SAMPLE: This was a cross-sectional study using a 30 item mailed survey to describe farmers' operations, demographics, health conditions, related information sources, and knowledge/attitude/practices for personal protective equipment (PPE) (i...
November 14, 2016: Public Health Nursing
https://www.readbyqxmd.com/read/27857956/exercise-in-personal-protective-equipment-in-a-hot-humid-environment-does-not-affect-risk-propensity
#13
Zachary J Schlader, Jennifer L Temple, David Hostler
We tested the hypothesis that heat stress created by light exertion in encapsulating personal protective equipment (PPE) in a hot, humid environment increases risk propensity. Ten healthy subjects (29 ± 7 y) completed 2 trials presented in a counter-balanced manner. Subjects donned encapsulating PPE, and in one trial they wore a tube-lined shirt underneath that was perfused with 5°C water. Subjects completed 2 15 min bouts of walking exercise on a treadmill at ˜50% maximal heart rate in a 32°C, 81% RH environment...
April 2016: Temperature: Multidisciplinary Biomedical Journal
https://www.readbyqxmd.com/read/27853031/the-post-ebola-virus-disease-scourge-in-nigeria-individual-levels-of-preparedness-among-physicians-in-the-federal-capital-territory-abuja
#14
Adewale L Alli, Maxwell M Nwegbu, Perpetua U Ibekwe, Titus S Ibekwe
BACKGROUND: Ebola virus disease (EVD) is a viral hemorrhagic illness with great propensity for spread across international borders. The latest outbreak in the West African region, which involved Nigeria, was the worst among previously documented 25 outbreaks since discovery in 1976. The Nigerian response toward attaining Ebola free status was phenomenal and a case study for most nations. However, the persistence of EVD in West Africa is still a risk to recurrence, hence, the need to assess the level of consciousness of Nigerian physicians towards this...
October 2016: Annals of African Medicine
https://www.readbyqxmd.com/read/27847258/previous-and-recent-maternal-experiences-modulate-pups-incentive-value-relative-to-a-male-without-affecting-maternal-behavior-in-postpartum-estrous-rats
#15
Daniella Agrati, Marcela Ferreño, Gabriella Marin, Natalia Uriarte, María José Zuluaga, Alonso Fernández-Guasti, Annabel Ferreira
This study extends the behavioral analysis of the postpartum estrus (PPE) which represents a unique period in the female rat's lifetime when maternal and sexual motivations co-exist. The aim of this study was to explore how previous and recent maternal experiences influence the maternal responses to pups when confronted with a male in a preference test or when they are presented independently in the home cage. To achieve this objective, we firstly compared the maternal behavior in the home cage and the preference for pups or a male in a Y-maze of primiparous and multiparous females approximately twelve hours after delivery...
November 12, 2016: Journal of Physiology, Paris
https://www.readbyqxmd.com/read/27836780/oxidative-stress-leads-to-reduction-of-plasmalogen-serving-as-a-novel-biomarker-for-systemic-lupus-erythematosus
#16
Changfeng Hu, Jia Zhou, Shasha Yang, Haichang Li, Chunyan Wang, Xiaoling Fang, Yongsheng Fan, Jida Zhang, Xianlin Han, Chengping Wen
Oxidative stress is elevated in systemic lupus erythematosus (SLE) patients, and associated extensively with SLE pathogenesis. However, no common indicators of oxidative stress are yet in routine clinical use because of their instability, nonspecificity, and non-representation of all SLE symptoms. Moreover, the method for reproducible analysis of reactive oxygen species is still lacking. Lipids and their metabolites are essential components of biological systems, many of which serve as molecular targets of oxidative stress and play crucial roles in signaling, inflammation, and immune responses...
November 9, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27834685/antagonism-of-cannabinoid-receptor-1-attenuates-the-anti-inflammatory-effects-of-electroacupuncture-in-a-rodent-model-of-migraine
#17
Hui Zhang, Shengdong He, Youping Hu, Hui Zheng
BACKGROUND: The anti-nociceptive effects of electroacupuncture (EA) in migraine have been documented in multiple randomised controlled trials. Neurogenic inflammation plays a key role in migraine attacks, and the anti-inflammatory effects of acupuncture have been associated with the type 1 cannabinoid (CB1) receptor. OBJECTIVE: To investigate whether CB1 receptors mediate the anti-inflammatory effects of EA on migraine attacks. METHODS: A migraine model was produced in Sprague-Dawley rats by unilateral electrical stimulation of the trigeminal ganglion (TGES)...
December 2016: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
https://www.readbyqxmd.com/read/27832744/infection-control-and-tuberculosis-among-health-care-workers-in-viet-nam-2009-2013-a-cross-sectional-survey
#18
Edine W Tiemersma, Nguyen Thien Huong, Pham Hoang Yen, Bui Thi Tinh, Tran Thi Bich Thuy, Nguyen Van Hung, Nguyen Thanh Mai, Suzanne Verver, Agnes Gebhard, Nguyen Viet Nhung
BACKGROUND: Data on tuberculosis (TB) among health care workers (HCW) and TB infection control (TBIC) indicators are rarely available at national level. We assessed multi-year trends in notification data of TB among HCW and explored possible associations with TBIC indicators. METHODS: Notified TB incidence among HCW and 3 other TBIC indicators were collected annually from all 64 provincial and 3 national TB facilities in Vietnam. Time trends in TB notification between 2009 and 2013 were assessed using linear regression analysis...
November 10, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27829907/microwave-assisted-cyclizations-promoted-by-polyphosphoric-acid-esters-a-general-method-for-1-aryl-2-iminoazacycloalkanes
#19
Jimena E Díaz, María C Mollo, Liliana R Orelli
The first general procedure for the synthesis of 5 to 7-membered 1-aryl-2-iminoazacycloalkanes is presented, by microwave-assisted ring closure of ω-arylaminonitriles promoted by polyphosphoric acid (PPA) esters. 1-Aryl-2-iminopyrrolidines were easily prepared from the acyclic precursors employing a chloroformic solution of ethyl polyphosphate (PPE). The use of trimethylsilyl polyphosphate (PPSE) in solvent-free conditions allowed for the synthesis of 1-aryl-2-iminopiperidines and hitherto unreported 1-aryl-2-iminoazepanes...
2016: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/27829013/neuroprotective-effects-of-pomegranate-peel-extract-after-chronic-infusion-with-amyloid-%C3%AE-peptide-in-mice
#20
Maressa Caldeira Morzelle, Jocelem Mastrodi Salgado, Milena Telles, Danilo Mourelle, Patricia Bachiega, Hudson Sousa Buck, Tania Araujo Viel
Alzheimer's disease is a chronic and degenerative condition that had no treatment until recently. The current therapeutic strategies reduce progression of the disease but are expensive and commonly cause side effects that are uncomfortable for treated patients. Functional foods to prevent and/or treat many conditions, including neurodegenerative diseases, represent a promising field of study currently gaining attention. To this end, here we demonstrate the effects of pomegranate (Punica granatum) peel extract (PPE) regarding spatial memory, biomarkers of neuroplasticity, oxidative stress and inflammation in a mouse model of neurodegeneration...
2016: PloS One
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