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https://www.readbyqxmd.com/read/29340898/epidemiological-aspects-of-healthcare-associated-infections-and-microbial-genomics
#1
C Mirande, I Bizine, A Giannetti, N Picot, A van Belkum
Hospital-acquired infections (HAIs) are a cause of continuously increasing morbidity and mortality. Most of these infections are caused by a limited set of bacterial species, which share the capability to efficiently spread from patient to patient and to easily acquire antibiotic resistance determinants. This renders correct and rapid species identification and antibiotic susceptibility testing (AST) important and underscores the relevance of bacterial epidemiological typing. The latter is needed for the sensitive detection and exact tracing of nosocomial spread of these potentially multidrug-resistant microorganisms (MDRO)...
January 17, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29333571/diurnal-variations-in-personal-care-products-in-seawater-and-mussels-at-three-mediterranean-coastal-sites
#2
Marina Picot-Groz, Hélène Fenet, Maria Jesus Martinez Bueno, David Rosain, Elena Gomez
The presence of personal care products (PCPs) in the marine environment is of major concern. PCPs, UV filters, and musks can enter the marine environment indirectly through wastewater or directly via recreational activities. We conducted this study to document patterns in the occurrence of seven PCPs at three coastal sites impacted by recreational activities during 1 day. The study focused on diurnal variations in these seven PCPs in seawater and indigenous mussels. In seawater, UV filters showed diurnal variations that mirrored variations in recreational activities at the sites...
January 15, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29303302/observation-of-the-identical-rigidity-dependence-of-he-c-and-o-cosmic-rays-at-high-rigidities-by-the-alpha-magnetic-spectrometer-on-the-international-space-station
#3
M Aguilar, L Ali Cavasonza, B Alpat, G Ambrosi, L Arruda, N Attig, S Aupetit, P Azzarello, A Bachlechner, F Barao, A Barrau, L Barrin, A Bartoloni, L Basara, S Başeğmez-du Pree, M Battarbee, R Battiston, U Becker, M Behlmann, B Beischer, J Berdugo, B Bertucci, K F Bindel, V Bindi, W de Boer, K Bollweg, V Bonnivard, B Borgia, M J Boschini, M Bourquin, E F Bueno, J Burger, W J Burger, F Cadoux, X D Cai, M Capell, S Caroff, J Casaus, G Castellini, F Cervelli, M J Chae, Y H Chang, A I Chen, G M Chen, H S Chen, L Cheng, H Y Chou, E Choumilov, V Choutko, C H Chung, C Clark, R Clavero, G Coignet, C Consolandi, A Contin, C Corti, W Creus, M Crispoltoni, Z Cui, K Dadzie, Y M Dai, A Datta, C Delgado, S Della Torre, O Demakov, M B Demirköz, L Derome, S Di Falco, F Dimiccoli, C Díaz, P von Doetinchem, F Dong, F Donnini, M Duranti, D D'Urso, A Egorov, A Eline, T Eronen, J Feng, E Fiandrini, P Fisher, V Formato, Y Galaktionov, G Gallucci, R J García-López, C Gargiulo, H Gast, I Gebauer, M Gervasi, A Ghelfi, F Giovacchini, D M Gómez-Coral, J Gong, C Goy, V Grabski, D Grandi, M Graziani, K H Guo, S Haino, K C Han, Z H He, M Heil, J Hoffman, T H Hsieh, H Huang, Z C Huang, C Huh, M Incagli, M Ionica, W Y Jang, Yi Jia, H Jinchi, S C Kang, K Kanishev, B Khiali, G N Kim, K S Kim, Th Kirn, C Konak, O Kounina, A Kounine, V Koutsenko, A Kulemzin, G La Vacca, E Laudi, G Laurenti, I Lazzizzera, A Lebedev, H T Lee, S C Lee, C Leluc, H S Li, J Q Li, Q Li, T X Li, Y Li, Z H Li, Z Y Li, S Lim, C H Lin, P Lipari, T Lippert, D Liu, Hu Liu, V D Lordello, S Q Lu, Y S Lu, K Luebelsmeyer, F Luo, J Z Luo, S S Lyu, F Machate, C Mañá, J Marín, T Martin, G Martínez, N Masi, D Maurin, A Menchaca-Rocha, Q Meng, V M Mikuni, D C Mo, P Mott, T Nelson, J Q Ni, N Nikonov, F Nozzoli, A Oliva, M Orcinha, F Palmonari, C Palomares, M Paniccia, M Pauluzzi, S Pensotti, C Perrina, H D Phan, N Picot-Clemente, F Pilo, C Pizzolotto, V Plyaskin, M Pohl, V Poireau, L Quadrani, X M Qi, X Qin, Z Y Qu, T Räihä, P G Rancoita, D Rapin, J S Ricol, S Rosier-Lees, A Rozhkov, D Rozza, R Sagdeev, S Schael, S M Schmidt, A Schulz von Dratzig, G Schwering, E S Seo, B S Shan, J Y Shi, T Siedenburg, D Son, J W Song, M Tacconi, X W Tang, Z C Tang, D Tescaro, Samuel C C Ting, S M Ting, N Tomassetti, J Torsti, C Türkoğlu, T Urban, V Vagelli, E Valente, E Valtonen, M Vázquez Acosta, M Vecchi, M Velasco, J P Vialle, V Vitale, S Vitillo, L Q Wang, N H Wang, Q L Wang, X Wang, X Q Wang, Z X Wang, C C Wei, Z L Weng, K Whitman, H Wu, X Wu, R Q Xiong, W Xu, Q Yan, J Yang, M Yang, Y Yang, H Yi, Y J Yu, Z Q Yu, M Zannoni, S Zeissler, C Zhang, F Zhang, J Zhang, J H Zhang, S W Zhang, Z Zhang, Z M Zheng, H L Zhuang, V Zhukov, A Zichichi, N Zimmermann, P Zuccon
We report the observation of new properties of primary cosmic rays He, C, and O measured in the rigidity (momentum/charge) range 2 GV to 3 TV with 90×10^{6} helium, 8.4×10^{6} carbon, and 7.0×10^{6} oxygen nuclei collected by the Alpha Magnetic Spectrometer (AMS) during the first five years of operation. Above 60 GV, these three spectra have identical rigidity dependence. They all deviate from a single power law above 200 GV and harden in an identical way.
December 22, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29298814/automated-plasmodium-detection-by-the-sysmex-xn-hematology-analyzer
#4
Cécile Dumas, Anne-Lise Bienvenu, Sandrine Girard, Stéphane Picot, Gisèle Debize, Brigitte Durand
BACKGROUND: Malaria is a potentially severe disease affecting nearly 200 million people per year. Early detection of the parasite even in unsuspected patients remains the challenging aim for effective patient care. Automated complete blood counts that are usually performed for any febrile patient might represent a tool to ascertain malaria infection. AIMS: To evaluate the ability of the new generation of the Sysmex hematology analyzer (XN-series) to detect malaria...
January 3, 2018: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29277535/determination-of-dolutegravir-s-unbound-fraction-in-human-plasma-using-validated-equilibrium-dialysis-and-lc-ms-ms-methods
#5
David Metsu, Thomas Lanot, François Fraissinet, Mélanie Picot, Didier Concordet, Marion Cabrol, Frédérique Dubois-Galopin, Etienne Chatelut, Pierre Delobel, Peggy Gandia
Assessment of the unbound pharmacologically active fraction (fu; as the ratio of unbound to total concentration) of dolutegravir could improve therapeutic drug monitoring (TDM) in patients that experience virological failure or toxicity, despite receiving adequate total concentrations. This study evaluated (i) dolutegravir's fu through equilibrium dialysis (ED), (ii) the pre-analytical parameters that influence fu, and (iii) fu's inter-individual variability in HIV patients. Validation of the LC-MS/MS method followed FDA guidelines...
December 22, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29273022/on-line-hemodiafiltration-did-not-induce-an-overproduction-of-oxidative-stress-and-inflammatory-cytokines-in-intensive-care-unit-acute-kidney-injury
#6
Kada Klouche, Laurent Amigues, Marion Morena, Vincent Brunot, Anne Marie Dupuy, Audrey Jaussent, Marie Christine Picot, Noémie Besnard, Delphine Daubin, Jean Paul Cristol
BACKGROUND: Though on-line intermittent hemodiafiltration (OL-IHDF) is a routine therapy for chronic dialysis patients, it is not yet widespread used in critically ill patients. This study was undergone to evaluate efficiency and tolerance of OL-IHDF and to appreciate inflammatory consequences of its use in intensive care unit (ICU)-acute kidney injury (AKI) patients. METHODS: In this prospective cohort study conducted in a medical academic ICU in France, 30 AKI patients who underwent OL-IHDF were included...
December 22, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29261755/interaction-between-environment-nutrient-derived-metabolites-and-immunity-a-possible-role-in-malaria-susceptibility-resistance-in-fulani-and-dogon-of-mali
#7
Karim Traore, Mahamadou A Thera, Anne-Lise Bienvenu, Charles Arama, Guillaume Bonnot, Adeline Lavoignat, Ogobara K Doumbo, Stephane Picot
The role of some nutrient-derived metabolites on the innate and adaptive immune responses is now established. Global research approach investigating the interplay between environment, lifestyle and the host's immune responses is crucial in the understanding of malaria susceptibility. Advanced Glycation end products (AGE), which are food-derived metabolites result from the link between reducing sugar and amino group of proteins, lipids or nucleic acids. The level of exposure to AGEs varies depending on the type of diet...
2017: PloS One
https://www.readbyqxmd.com/read/29251261/diagnostic-accuracy-of-loop-mediated-isothermal-amplification-lamp-for-screening-patients-with-imported-malaria-in-a-non-endemic-setting
#8
Camille Ponce, Flora Kaczorowski, Thomas Perpoint, Patrick Miailhes, Alain Sigal, Etienne Javouhey, Yves Gillet, Laurent Jacquin, Marion Douplat, Karim Tazarourte, Véronique Potinet, Bruno Simon, Adeline Lavoignat, Guillaume Bonnot, Fatimata Sow, Anne-Lise Bienvenu, Stéphane Picot
BACKGROUND: Sensitive and easy-to-perform methods for the diagnosis of malaria are not yet available. Improving the limit of detection and following the requirements for certification are issues to be addressed in both endemic and non-endemic settings. The aim of this study was to test whether loop-mediated isothermal amplification of DNA (LAMP) may be an alternative to microscopy or real-time PCR for the screening of imported malaria cases in non-endemic area. RESULTS: 310 blood samples associated with 829 suspected cases of imported malaria were tested during a one year period...
2017: Parasite: Journal de la Société Française de Parasitologie
https://www.readbyqxmd.com/read/29191610/incidence-and-prevention-of-infective-endocarditis-and-bacteraemia-after-transcatheter-aortic-valve-implantation-in-a-french-university-hospital-a-retrospective-study
#9
M Gallouche, G Barone-Rochette, P Pavese, B Bertrand, G Vanzetto, H Bouvaist, I Pierre, D Schmitt, J Fauconnier, Y Caspar, C Recule, R Picot-Guéraud, J P Stahl, M R Mallaret, C Landelle
Infective endocarditis (IE) after transcatheter aortic valve implantation (TAVI) is a rare but severe complication. Among 326 patients who underwent TAVI in Grenoble Alpes university hospital, 6 (1.8%) IE cases and 11 (3.4%) bacteraemia cases were identified. No EI was linked to the intervention; one was due to Staphylococcus aureus despite a screening and targeted decolonization strategy. This underscores the need for randomized studies to evaluate benefit and cost-effectiveness of this policy.
November 27, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29188878/effect-of-a-6-month-brisk-walking-program-on-walking-endurance-in-sedentary-and-physically-deconditioned-women-aged-60-or-older-a-randomized-trial
#10
H Blain, A Jaussent, M-C Picot, L Maimoun, O Coste, T Masud, J Bousquet, P L Bernard
BACKGROUND: Walking endurance is a predictor of healthy ageing. OBJECTIVE: To examine if a 6-month brisk walking program can increase walking endurance in sedentary and physically deconditioned older women. TRIAL DESIGN: Randomized controlled trial. SETTING: Women recruited from public meetings aimed at promoting physical activity in women aged 60 or older. SUBJECTS: 121 women aged 65.7 ± 4.3 years, with sedentary lifestyle (Physical Activity Questionnaire for the Elderly score < 9...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29170358/cardiopulmonary-fitness-in-children-with-congenital-heart-diseases-versus-healthy-children
#11
Pascal Amedro, Arthur Gavotto, Sophie Guillaumont, Helena Bertet, Marie Vincenti, Gregoire De La Villeon, Charlène Bredy, Philippe Acar, Caroline Ovaert, Marie-Christine Picot, Stefan Matecki
OBJECTIVE: We aimed to compare the cardiopulmonary fitness of children with congenital heart diseases (CHD) with that of age-adjusted and gender-adjusted controls. We also intended to identify clinical characteristics associated with maximum oxygen uptake (VO2max) in this population. METHODS AND RESULTS: We included in a cross-sectional multicentre study a total of 798 children (496 CHD and 302 controls) who underwent a complete cardiopulmonary exercise test (CPET)...
November 23, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29157036/epigallocatechin-3-o-gallate-alleviates-the-malignant-phenotype-in-a-431-epidermoid-and-sk-br-3-breast-cancer-cell-lines
#12
Alexandru Filippi, Tiphanie Picot, Carmen Mariana Aanei, Péter Nagy, János Szöllősi, Lydia Campos, Constanţa Ganea, Maria-Magdalena Mocanu
In this study, we evaluated the effects of epigallocatechin-3-O-gallate (EGCG) in two cancer cell lines, A-431 overexpressing ErbB1 and SK-BR-3, overexpressing ErbB2. EGCG treatment showed dose-dependent collapse of mitochondrial membrane potential (Δψm), increase in reactive oxygen species (ROS) production, changes in nuclear morphology and reduced viability. Flow cytometry data indicated that EGCG partially decreases the phosphorylation of several proteins involved in cell proliferation and survival: pErbB1(Y1173, Y1068), pAkt(S473) and pERK(Y204)...
November 21, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/29127811/distribution-and-incidence-of-atoxigenic-aspergillus-flavus-vcg-in-tree-crop-orchards-in-california-a-strategy-for-identifying-potential-antagonists-the-example-of-almonds
#13
Adeline Picot, Mark Doster, Md-Sajedul Islam, Kenneth Callicott, Alejandro Ortega-Beltran, Peter Cotty, Themis Michailides
To identify predominant isolates for potential use as biocontrol agents, Aspergillus flavus isolates collected from soils of almond, pistachio and fig orchard in the Central Valley of California were tested for their membership to 16 atoxigenic vegetative compatibility groups (VCGs), including YV36, the VCG to which AF36, an atoxigenic isolate commercialized in the United States as biopesticide, belongs. A surprisingly large proportion of isolates belonged to YV36 (13.3%, 7.2% and 6.6% of the total almond, pistachio and fig populations, respectively), while the percentage of isolates belonging to the other 15 VCGs ranged from 0% to 2...
January 16, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29100908/quality-of-life-in-children-participating-in-a-non-selective-inr-self-monitoring-vka-education-programme
#14
Pascal Amedro, Fanny Bajolle, Helena Bertet, Radhia Cheurfi, Dominique Lasne, Erika Nogue, Pascal Auquier, Marie-Christine Picot, Damien Bonnet
BACKGROUND: The quality of life (QoL) of children receiving vitamin K antagonist (VKA) treatment has been scarcely studied. AIM: To assess QoL of children, and its evolution, throughout our non-selective international normalized ratio (INR) self-monitoring education programme. METHODS: Children and parents completed QoL questionnaires (Qualin, PedsQL) during education sessions. Scores were compared with those from controls. RESULTS: A total of 111 children (mean±standard deviation age 8...
October 31, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/29080311/the-framing-of-research-questions-using-the-picot-format-in-randomized-controlled-trials-of-venous-ulcer-disease-is-sub-optimal-a-systematic-survey
#15
Luciana P F Abbade, Mei Wang, Kamath Sriganesh, Yanling Jin, Lawrence Mbuagbaw, Lehana Thabane
Despite several publications on venous ulcers, there is still a lack of evidence from randomized controlled trials (RCTs) to support certain treatments for patients with this disorder. Well-designed research questions using the PICOT (Population; Intervention; Comparator; Outcome; Time-frame) format in RCTs can improve the quality of research. The objectives of this study were to assess how the PICOT format is used to frame research questions in RCTs published on venous ulcer disease and to determine the factors associated with better adherence to the PICOT format...
October 28, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29045307/prevalence-of-antipsychotic-treated-patients-in-a-cohort-of-adult-addicted-patients
#16
Hélène Peyrière, Caroline Diot, Erika Nogue, Marie Verschave, Morgan Laure, Marie-Christine Picot, Pierre Petit, Hélène Donnadieu-Rigole, Yves Leglise
PURPOSE: The objective of this cross-sectional study was to describe and estimate the prevalence of antipsychotics (AP) in a cohort of addicted patients, and to compare the profiles of addictive patients receiving AP or not. METHODS: We included all adult patients seen at the addiction care center of Montpellier University Hospital, between January 1, 2015, and March 31, 2015. Demographic, clinical, and therapeutic data were collected from the patients' medical records...
October 17, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29026971/is-impaired-cerebral-vasoreactivity-an-early-marker-of-cognitive-decline-in-multiple-sclerosis-patients
#17
Aude Metzger, Emmanuelle Le Bars, Jeremy Deverdun, François Molino, Bénédicte Maréchal, Marie-Christine Picot, Xavier Ayrignac, Clarisse Carra, Luc Bauchet, Alexandre Krainik, Pierre Labauge, Nicolas Menjot de Champfleur
OBJECTIVE: The link between cerebral vasoreactivity and cognitive status in multiple sclerosis remains unclear. The aim of the present study was to investigate a potential decrease of cerebral vasoreactivity in multiple sclerosis patients and correlate it with cognitive status. METHODS: Thirty-three patients with multiple sclerosis (nine progressive and 24 remitting forms, median age: 39 years, 12 males) and 22 controls underwent MRI with a hypercapnic challenge to assess cerebral vasoreactivity and a neuropsychological assessment...
October 12, 2017: European Radiology
https://www.readbyqxmd.com/read/28986035/estimating-the-full-public-health-value-of-vaccination
#18
Bradford D Gessner, David Kaslow, Jacques Louis, Kathleen Neuzil, Katherine L O'Brien, Valentina Picot, Tikki Pang, Umesh D Parashar, Mitra Saadatian-Elahi, Christopher B Nelson
There is an enhanced focus on considering the full public health value (FPHV) of vaccination when setting priorities, making regulatory decisions and establishing implementation policy for public health activities. Historically, a therapeutic paradigm has been applied to the evaluation of prophylactic vaccines and focuses on an individual benefit-risk assessment in prospective and individually-randomized phase III trials to assess safety and efficacy against etiologically-confirmed clinical outcomes. By contrast, a public health paradigm considers the population impact and encompasses measures of community benefits against a range of outcomes...
October 3, 2017: Vaccine
https://www.readbyqxmd.com/read/28983797/clinical-factors-associated-with-decision-to-recommend-methylphenidate-treatment-for-children-with-adhd-in-france
#19
Elodie Courtabessis, Florence Pupier, Laurie Surig, Marie-Christine Picot, Erika Nogué, Valérie Macioce, Elizabeth Stein, Diane Purper-Ouakil
European guidelines advise on best practices for the diagnosis and non-pharmacological and pharmacological treatment of attention-deficit hyperactivity disorder (ADHD). This study aimed to (1) assess whether clinician's decisions to initiate methylphenidate treatment in children diagnosed with ADHD are in accordance with European guidelines and (2) identify clinical factors associated with the decision to recommend methylphenidate prescription. 5 to 13-year-old patients with an ADHD diagnosis were consecutively evaluated in an outpatient child and adolescent psychiatry clinic in France...
October 5, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28947166/upper-limb-isokinetic-strengthening-versus-passive-mobilization-in-patients-with-chronic-stroke-a-randomized-controlled-trial
#20
F Coroian, C Jourdan, K Bakhti, C Palayer, A Jaussent, M C Picot, D Mottet, M Julia, H Y Bonnin, I Laffont
OBJECTIVE: To assess the benefit of isokinetic strengthening (IS) of the upper limb (UL) in chronic stroke patients, compared to passive mobilization. DESIGN: Randomized blinded assessor controlled trial. SETTING: PRM departments of two University Hospitals. PARTICIPANTS: 20 patients with incomplete hemiplegia, 16 men, mean age 64 years, median time since stroke 32 months. INTERVENTION: A 6-week comprehensive rehabilitation program, 3 days/week, three sessions/day...
September 22, 2017: Archives of Physical Medicine and Rehabilitation
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