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https://www.readbyqxmd.com/read/28431626/sleep-patterns-in-villagers-and-urban-african-volunteers-in-a-humid-tropical-climate-influence-of-accessibility-to-electric-light
#1
Alain Buguet, Pascal Bogui, Stéphane Picot, Raymond Cespuglio
Recent publications focusing on sleep-wake alternation, using actigraphic recordings in hunter-gatherers, stressed the existence of a potential effect of electricity availability on sleep habits. These reports prompted us to achieve a new analysis of the polysomnographic data already obtained in healthy African volunteers in equatorial Africa during two different investigations. Comparison of the 24-h polysomnographic sleep patterns were done between 9 volunteers sleeping in a laboratory in Abidjan (Abidjan cohort) and 11 villagers living in electricity-free bush villages (Sinfra cohort)...
May 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28366395/corrigendum-to-evidence-of-the-bioaccumulation-of-ciguatoxins-in-giant-clams-tridacna-maxima-exposed-to-gambierdiscus-spp-cells-harmful-algae-57-2016-78-87
#2
Mélanie Roué, Hélène Taiana Darius, Sandy Picot, André Ung, Jérôme Viallon, Nabila Gaertner-Mazouni, Manoella Sibat, Zouher Amzil, Mireille Chinain
No abstract text is available yet for this article.
March 2017: Harmful Algae
https://www.readbyqxmd.com/read/28357840/possible-outbreak-of-skin-infections-due-to-panton-valentine-leukocidin-positive-methicillin-resistant-staphylococcus-aureus-on-a-commercial-ship-in-2012-2014
#3
Etienne Bon, Kheira Gadouri, Catherine Avril, Guillaume Camuset, Elsa Balleydier, Isabelle Mathieu, Sandrine Picot, Julien Jaubert, Richard Ballas, Mélanie Colomb-Cotinat, Anne Tristan, Coralie Bouchiat, Laurent Filleul, Frédéric Pagès
No abstract text is available yet for this article.
2017: International Maritime Health
https://www.readbyqxmd.com/read/28323325/the-evolution-of-siderophore-production-as-a-competitive-trait
#4
Rene Niehus, Aurore Picot, Nuno M Oliveira, Sara Mitri, Kevin R Foster
Microbes have the potential to be highly cooperative organisms. The archetype of microbial cooperation is often considered to be the secretion of siderophores, molecules scavenging iron, where cooperation is threatened by "cheater" genotypes that use siderophores without making them. Here, we show that this view neglects a key piece of biology: siderophores are imported by specific receptors that constrain their use by competing strains. We study the effect of this specificity in an ecoevolutionary model, in which we vary siderophore sharing among strains, and compare fully shared siderophores with private siderophores...
March 21, 2017: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/28318624/treatment-tolerance-and-patient-reported-outcomes-favor-online-hemodiafiltration-compared-to-high-flux-hemodialysis-in-the-elderly
#5
Marion Morena, Audrey Jaussent, Lotfi Chalabi, Hélène Leray-Moragues, Leila Chenine, Alain Debure, Damien Thibaudin, Lynda Azzouz, Laure Patrier, Francois Maurice, Philippe Nicoud, Claude Durand, Bruno Seigneuric, Anne-Marie Dupuy, Marie-Christine Picot, Jean-Paul Cristol, Bernard Canaud
Large cohort studies suggest that high convective volumes associated with online hemodiafiltration may reduce the risk of mortality/morbidity compared to optimal high-flux hemodialysis. By contrast, intradialytic tolerance is not well studied. The aim of the FRENCHIE (French Convective versus Hemodialysis in Elderly) study was to compare high-flux hemodialysis and online hemodiafiltration in terms of intradialytic tolerance. In this prospective, open-label randomized controlled trial, 381 elderly chronic hemodialysis patients (over age 65) were randomly assigned in a one-to-one ratio to either high-flux hemodialysis or online hemodiafiltration...
March 15, 2017: Kidney International
https://www.readbyqxmd.com/read/28295206/molecular-clinical-and-neuropsychological-study-in-31-patients-with-kabuki-syndrome-and-kmt2d-mutations
#6
Natacha Lehman, Anne Claire Mazery, Antoine Visier, Clarisse Baumann, Dominique Lachesnais, Yline Capri, Annick Toutain, Sylvie Odent, Myriam Mikaty, Cyril Goizet, Emmanuelle Taupiac, Marie Line Jacquemont, Elodie Sanchez, Elise Schaefer, Vincent Gatinois, Laurence Faivre, Delphine Minot, Honorine Kayirangwa, Kim-Hanh Le Qang Sang, Nathalie Boddaert, Sophie Bayard, Didier Lacombe, Sébastien Moutton, Isabelle Touitou, Marlène Rio, Jeanne Amiel, Stanislas Lyonnet, Damien Sanlaville, Marie Christine Picot, David Geneviève
Kabuki syndrome (KS - OMIM 147920) is a rare developmental disease characterized by the association of multiple congenital anomalies and intellectual disability. This study aimed to investigate intellectual performance in children with Kabuki syndrome and link the performance to several clinical features and molecular data. We recruited 31 children with KMT2D mutations who were 6 to 16 years old. They all completed the Weschler Intelligence Scale for Children, fourth edition. We calculated all indexes: the Full Scale Intellectual Quotient (FSIQ), Verbal Comprehension Index (VCI), Perceptive Reasoning Index (PRI), Processing Speed Index (PSI), and Working Memory Index (WMI)...
March 14, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28290249/in-vitro-and-in-silico-studies-of-mangiferin-from-aphloia-theiformis-on-key-enzymes-linked-to-diabetes-type-2-and-associated-complications
#7
Marie C N Picot, Gokhan Zengin, Adriano Mollica, Azzurra Stefanucci, Simone Carradori, Mohamad F Mahomoodally
BACKGROUND: Mangiferin, was identified in the crude methanol extract, ethyl acetate, and n-butanol fractions of Aphloia theiformis (Vahl.) Benn. OBJECTIVE: To study the plausible binding modes of mangiferin to key enzymes linked to diabetes type 2 (DT2), obesity, hypertension, Alzheimer's disease, and urolithiasis using molecular docking. METHOD: Crystallographic structures of α-amylase, α-glucosidase, glycogen phosphorylase (GP), pancreatic lipase, cholesterol esterase (CEase), angiotensin-I-converting enzyme (ACE), acetyl cholinesterase (AChE), and urease available on the Protein Databank database were docked to mangiferin using Gold 6...
March 7, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/28257842/picot-alleviates-myocardial-ischemia-reperfusion-injury-by-reducing-intracellular-levels-of-reactive-oxygen-species
#8
Jihwa Kim, Jooyeon Kim, Hyun Kook, Woo Jin Park
Excessive generation of reactive oxygen species (ROS) is one of the main causes of myocardial ischemia-reperfusion (I/R) injury. In this study, we investigated the role of protein kinase C-interacting cousin of thioredoxin (PICOT; Grx3) during myocardial I/R using PICOT transgenic (TG) and knockdown (KD) mice. Infarction and apoptosis were attenuated in PICOT TG mice but exacerbated in PICOT KD mice upon I/R. In parallel, I/R-induced generation of ROS was attenuated in PICOT TG mice but exacerbated in PICOT KD mice...
April 15, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28242543/multiple-pharmacological-targets-cytotoxicity-and-phytochemical-profile-of-aphloia-theiformis-vahl-benn
#9
Marie Carene Nancy Picot, Onur Bender, Arzu Atalay, Gokhan Zengin, Loïc Loffredo, Francis Hadji-Minaglou, Mohamad Fawzi Mahomoodally
Aphloia theiformis (Vahl.) Benn. (AT) is traditionally used in Sub-Saharan African countries including Mauritius as a biomedicine for the management of several diseases. However, there is a dearth of experimental studies to validate these claims. We endeavoured to evaluate the inhibitory effects of crude aqueous extract as traditionally used together with the crude methanol extracts of AT leaves on urease, angiotensin (I) converting enzyme (ACE), acetylcholinesterase (AChE), cholesterol esterase (CEase), glycogen phosphorylase a (GPa), and glycation in vitro...
February 24, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28231253/community-analysis-of-pigment-patterns-from-37-microalgae-strains-reveals-new-carotenoids-and-porphyrins-characteristic-of-distinct-strains-and-taxonomic-groups
#10
Benoît Serive, Elodie Nicolau, Jean-Baptiste Bérard, Raymond Kaas, Virginie Pasquet, Laurent Picot, Jean-Paul Cadoret
Phytoplankton, with an estimated 30 000 to 1 000 000 species clustered in 12 phyla, presents a high taxonomic and ecophysiological diversity, reflected by the complex distribution of pigments among the different algal classes. High performance liquid chromatography is the gold standard method for qualitative and quantitative analysis of phytoplankton pigments in seawater and culture samples, but only a few pigments can be used as robust chemotaxonomic markers. A major challenge is thus to identify new ones, characteristic of a strain, species, class or taxon that cannot be currently identified on the basis of its pigment signature...
2017: PloS One
https://www.readbyqxmd.com/read/28205355/trametes-polyzona-an-emerging-filamentous-basidiomycete-in-r%C3%A3-union-island
#11
Alexandre Gauthier, Julien Jaubert, Nicolas Traversier, Jérôme Lemant, Laurent Balu, Dea Garcia-Hermoso, Stephane Welti, Anne Favel, Sandrine Picot, Gautier Hoarau
We describe two serious Trametes polyzona pulmonary infections, which occurred in Réunion Island, in critically ill patients. The identification was performed using sequencing of the internal transcribed spacer region of ribosomal DNA and D1/D2 region of 28S rDNA. In one case, the significance of T. polyzona in the pathological process was certain, proven by histopathological evidence of fungal lung infection. T. polyzona, an emerging filamentous basidiomycete, prevalent in tropical areas, has not been described so far in human infections...
February 16, 2017: Mycoses
https://www.readbyqxmd.com/read/28181518/using-graphene-networks-to-build-bioinspired-self-monitoring-ceramics
#12
Olivier T Picot, Victoria G Rocha, Claudio Ferraro, Na Ni, Eleonora D'Elia, Sylvain Meille, Jerome Chevalier, Theo Saunders, Ton Peijs, Mike J Reece, Eduardo Saiz
The properties of graphene open new opportunities for the fabrication of composites exhibiting unique structural and functional capabilities. However, to achieve this goal we should build materials with carefully designed architectures. Here, we describe the fabrication of ceramic-graphene composites by combining graphene foams with pre-ceramic polymers and spark plasma sintering. The result is a material containing an interconnected, microscopic network of very thin (20-30 nm), electrically conductive, carbon interfaces...
February 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28166374/a-potential-role-for-the-secretogranin-ii-derived-peptide-em66-in-the-hypothalamic-regulation-of-feeding-behavior
#13
F Trebak, I Dubuc, A Arabo, A Alaoui, L Boukhzar, J Maucotel, M Picot, S Cherifi, C Duparc, J Leprince, G Prévost, Y Anouar, R Magoul, N Chartrel
EM66 is a conserved 66-amino acid peptide derived from secretogranin II (SgII), a member of the granin protein family. EM66 is widely distributed in secretory granules of endocrine and neuroendocrine cells as well as in hypothalamic neurons. Although EM66 is abundant in the hypothalamus, its physiological function remains to be elucidated. The aim of the present study was to investigate a possible involvement of EM66 in the hypothalamic regulation of feeding behavior. We show that ICV administration of EM66 induces a drastic dose-dependent inhibition of food intake in mice deprived of food for 18 h, which is associated with an increase of hypothalamic POMC and MC3R mRNA levels and c-Fos immunoreactivity in the POMC neurons of the arcuate nucleus...
February 6, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28153009/genetic-diversity-of-plasmodium-vivax-metacaspase-1-and-plasmodium-vivax-multi-drug-resistance-1-genes-of-field-isolates-from-mauritania-sudan-and-oman
#14
Fatimata Sow, Guillaume Bonnot, Bilal Rabah Ahmed, Sidi Mohamed Diagana, Hachim Kebe, Mohamedou Koita, Ba Malado Samba, Said K Al-Mukhaini, Majed Al-Zadjali, Seif S Al-Abri, Osama A M Ali, Abdallah M Samy, Muzamil Mahdi Abdel Hamid, Musab M Ali Albsheer, Bruno Simon, Anne-Lise Bienvenu, Eskild Petersen, Stéphane Picot
BACKGROUND: Plasmodium vivax is the second most important human malaria parasite, widely spread across the world. This parasite is associated with important issues in the process toward malaria elimination, including potential for relapse and increased resistance to chloroquine. Plasmodium vivax multi-drug resistant (pvmdr1) is suspected to be a marker of resistance although definitive evidence is lacking. Progress has been made in knowledge of biological factors affecting parasite growth, including mechanisms of regulated cell death and the suspected role of metacaspase...
February 2, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28152635/self-poisoning-with-baclofen-in-alcohol-dependent-patients-national-reports-to-french-poison-control-centers-2008-2013
#15
MULTICENTER STUDY
Fanny Pelissier, Luc de Haro, Florence Cardona, Cyndie Picot, Emmanuel Puskarczyk, Jean-Marc Sapori, Christine Tournoud, Nicolas Franchitto
BACKGROUND: Alcohol use disorders are frequently associated with self-intoxication in attempted suicide. In France since 2008, the off-label use of baclofen for treatment of alcohol dependence has greatly increased, leading to temporary regulation of use of the drug. At the request of the national authorities, the French Poison Control Centers carried out a retrospective survey to give an overview of baclofen exposure in this population. METHODS: A retrospective study was carried out from January 2008 to December 2013, focusing on baclofen exposures in alcohol-dependent patients managed by the nine national French Poison Control Centers...
April 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28142315/effects-of-aphloia-theiformis-on-key-enzymes-related-to-diabetes-mellitus
#16
Marie Carene Nancy Picot, Mohamad Fawzi Mahomoodally
CONTEXT: Aphloia theiformis (Vahl.) Benn. (Flacourtiaceae) (AT) is traditionally used for the management of diabetes mellitus (DM), but there is no scientific data regarding activity against enzymes linked to this condition. OBJECTIVE: To evaluate the kinetics of AT on key enzymes inhibition related to DM, and establish the antioxidant profile of AT. MATERIALS AND METHODS: Dried powdered AT leaves were used to prepare crude methanol extract (70% v/v) (CME)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28050868/field-assessment-of-the-new-rapid-diagnostic-test-ebola-ezyscreen-%C3%A2
#17
F Gallais, F Gay-Andrieu, V Picot, N Magassouba, S Mély, C N Peyrefitte, L Bellanger
During the Ebola virus disease outbreak in West Africa in 2014, the World Health Organization has pointed out the need for rapid diagnostic tests (RDT) affordable, sensitive, specific, user-friendly, rapid, equipment-free, and deliverable. The rapid diagnostic test (Lateral Flow Assay) Ebola eZYSCREEN(®) was developed in this emergency frame using monoclonal antibodies against the envelope glycoprotein of the virus. Two distinct versions have been industrialized, one for whole-blood samples and the other for serum/plasma samples...
January 3, 2017: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/27982618/precision-measurement-of-the-boron-to-carbon-flux-ratio-in-cosmic-rays-from-1-9%C3%A2-gv-to-2-6%C3%A2-tv-with-the-alpha-magnetic-spectrometer-on-the-international-space-station
#18
M Aguilar, L Ali Cavasonza, G Ambrosi, L Arruda, N Attig, S Aupetit, P Azzarello, A Bachlechner, F Barao, A Barrau, L Barrin, A Bartoloni, L Basara, S Başeğmez-du Pree, M Battarbee, R Battiston, U Becker, M Behlmann, B Beischer, J Berdugo, B Bertucci, K F Bindel, V Bindi, G Boella, W de Boer, K Bollweg, V Bonnivard, B Borgia, M J Boschini, M Bourquin, E F Bueno, J Burger, F Cadoux, X D Cai, M Capell, S Caroff, J Casaus, G Castellini, F Cervelli, M J Chae, Y H Chang, A I Chen, G M Chen, H S Chen, L Cheng, H Y Chou, E Choumilov, V Choutko, C H Chung, C Clark, R Clavero, G Coignet, C Consolandi, A Contin, C Corti, W Creus, M Crispoltoni, Z Cui, Y M Dai, C Delgado, S Della Torre, O Demakov, M B Demirköz, L Derome, S Di Falco, F Dimiccoli, C Díaz, P von Doetinchem, F Dong, F Donnini, M Duranti, D D'Urso, A Egorov, A Eline, T Eronen, J Feng, E Fiandrini, E Finch, P Fisher, V Formato, Y Galaktionov, G Gallucci, B García, R J García-López, C Gargiulo, H Gast, I Gebauer, M Gervasi, A Ghelfi, F Giovacchini, P Goglov, D M Gómez-Coral, J Gong, C Goy, V Grabski, D Grandi, M Graziani, K H Guo, S Haino, K C Han, Z H He, M Heil, J Hoffman, T H Hsieh, H Huang, Z C Huang, C Huh, M Incagli, M Ionica, W Y Jang, H Jinchi, S C Kang, K Kanishev, G N Kim, K S Kim, Th Kirn, C Konak, O Kounina, A Kounine, V Koutsenko, M S Krafczyk, G La Vacca, E Laudi, G Laurenti, I Lazzizzera, A Lebedev, H T Lee, S C Lee, C Leluc, H S Li, J Q Li, J Q Li, Q Li, T X Li, W Li, Y Li, Z H Li, Z Y Li, S Lim, C H Lin, P Lipari, T Lippert, D Liu, Hu Liu, V D Lordello, S Q Lu, Y S Lu, K Luebelsmeyer, F Luo, J Z Luo, S S Lv, F Machate, R Majka, C Mañá, J Marín, T Martin, G Martínez, N Masi, D Maurin, A Menchaca-Rocha, Q Meng, V M Mikuni, D C Mo, L Morescalchi, P Mott, T Nelson, J Q Ni, N Nikonov, F Nozzoli, A Oliva, M Orcinha, F Palmonari, C Palomares, M Paniccia, M Pauluzzi, S Pensotti, R Pereira, N Picot-Clemente, F Pilo, C Pizzolotto, V Plyaskin, M Pohl, V Poireau, A Putze, L Quadrani, X M Qi, X Qin, Z Y Qu, T Räihä, P G Rancoita, D Rapin, J S Ricol, S Rosier-Lees, A Rozhkov, D Rozza, R Sagdeev, J Sandweiss, P Saouter, S Schael, S M Schmidt, A Schulz von Dratzig, G Schwering, E S Seo, B S Shan, J Y Shi, T Siedenburg, D Son, J W Song, W H Sun, M Tacconi, X W Tang, Z C Tang, L Tao, D Tescaro, Samuel C C Ting, S M Ting, N Tomassetti, J Torsti, C Türkoğlu, T Urban, V Vagelli, E Valente, C Vannini, E Valtonen, M Vázquez Acosta, M Vecchi, M Velasco, J P Vialle, V Vitale, S Vitillo, L Q Wang, N H Wang, Q L Wang, X Wang, X Q Wang, Z X Wang, C C Wei, Z L Weng, K Whitman, J Wienkenhöver, H Wu, X Wu, X Xia, R Q Xiong, W Xu, Q Yan, J Yang, M Yang, Y Yang, H Yi, Y J Yu, Z Q Yu, S Zeissler, C Zhang, J Zhang, J H Zhang, S D Zhang, S W Zhang, Z Zhang, Z M Zheng, Z Q Zhu, H L Zhuang, V Zhukov, A Zichichi, N Zimmermann, P Zuccon
Knowledge of the rigidity dependence of the boron to carbon flux ratio (B/C) is important in understanding the propagation of cosmic rays. The precise measurement of the B/C ratio from 1.9 GV to 2.6 TV, based on 2.3 million boron and 8.3 million carbon nuclei collected by AMS during the first 5 years of operation, is presented. The detailed variation with rigidity of the B/C spectral index is reported for the first time. The B/C ratio does not show any significant structures in contrast to many cosmic ray models that require such structures at high rigidities...
December 2, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27979684/laboratory-tests-for-legionnaire-s-disease
#19
REVIEW
W Michael Dunne, Nathalie Picot, Alex van Belkum
Legionella pneumophila is one of the more recently discovered bacterial pathogens of humans. The last 2 decades have seen tremendous progress in the evolution of diagnostic tests, for detection and characterization of this pathogen and for defining the host response to infection. This has generated several diagnostic tools that span the range from simple immunologic assays to modern genome sequencing. This review describes the state of affairs of this continuously evolving field regarding the diagnosis of Legionnaire's disease and covers detection, assessment of antibiotic susceptibility, and epidemiologic characterization of isolates of L pneumophila and other pathogenic species within the genus...
December 12, 2016: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/27965532/the-neuropeptide-26rfa-qrfp-and-its-role-in-the-regulation-of-energy-homeostasis-a-mini-review
#20
REVIEW
Nicolas Chartrel, Marie Picot, Mouna El Medhi, Arnaud Arabo, Hind Berrahmoune, David Alexandre, Julie Maucotel, Youssef Anouar, Gaëtan Prévost
This mini-review deals with the neuropeptide 26RFa (or QRFP) which is a member of the RFamide peptide family discovered simultaneously by three groups in 2003. 26RFa (or its N-extended form 43RFa) was subsequently shown to be the endogenous ligand of the human orphan receptor GPR103. In the brain, 26RFa and GPR103mRNA are primarily expressed in hypothalamic nuclei involved in the control of feeding behavior, and at the periphery, the neuropeptide and its receptor are present in abundance in the gut and the pancreatic islets, suggesting that 26RFa is involved in the regulation of energy metabolism...
2016: Frontiers in Neuroscience
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