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https://www.readbyqxmd.com/read/27883170/macvia-lr-fighting-chronic-diseases-for-active-and-healthy-ageing-in-languedoc-roussillon-a-success-story-of-the-european-innovation-partnership-on-active-and-healthy-ageing
#1
J Bousquet, R Bourret, T Camuzat, P Augé, J Bringer, M Noguès, O Jonquet, J E de la Coussaye, J Ankri, M Cesari, O Guérin, B Vellas, H Blain, S Arnavielhe, A Avignon, B Combe, G Canovas, C Daien, G Dray, A Dupeyron, C Jeandel, I Laffont, D Laune, C Marion, E Pastor, J Y Pélissier, B Galan, J Reynes, J C Reuzeau, A Bedbrook, S Granier, P A Adnet, M Amouyal, B Alomène, P L Bernard, C Berr, D Caimmi, P G Claret, D J Costa, J P Cristol, P Fesler, D Hève, J Millot-Keurinck, D Morquin, G Ninot, M C Picot, N Raffort, F Roubille, A Sultan, J Touchon, V Attalin, C Azevedo, M Badin, K Bakhti, B Bardy, M P Battesti, X Bobia, C Boegner, S Boichot, H Y Bonnin, S Bouly, C Boubakri, J L Bourrain, G Bourrel, V Bouix, V Bruguière, S Cade, W Camu, V Carre, G Cavalli, G Cayla, R Chiron, P Coignard, F Coroian, P Costa, J Cottalorda, B Coulet, A L Coupet, M C Courrouy-Michel, P Courtet, V Cros, F Cuisinier, M Danko, P Dauenhauer, M Dauzat, M David, J M Davy, D Delignières, P Demoly, J Desplan, P Dujols, G Dupeyron, O Engberink, M Enjalbert, C Fattal, J Fernandes, M Fouletier, P Fraisse, P Gabrion, M Gellerat-Rogier, A Gelis, C Genis, N Giraudeau, A Y Goucham, F Gouzi, F Gressard, J C Gris, B Guillot, D Guiraud, V Handweiler, M Hayot, C Hérisson, C Heroum, D Hoa, S Jacquemin, S Jaber, D Jakovenko, C Jorgensen, P Kouyoudjian, R Lamoureux, L Landreau, M Lapierre, D Larrey, C Laurent, M S Léglise, J M Lemaitre, A Le Quellec, F Leclercq, S Lehmann, B Lognos, Cj M Lussert, A Makinson, K Mandrick, P Mares, P Martin-Gousset, A Matheron, G Mathieu, M Meissonnier, G Mercier, P Messner, C Meunier, M Mondain, R Morales, J Morel, D Mottet, P Nérin, P Nicolas, F Nouvel, D Paccard, G Pandraud, M P Pasdelou, J L Pasquié, K Patte, S Perrey, Y M Pers, F Portejoie, J L E Pujol, X Quantin, I Quéré, S Ramdani, J Ribstein, I Rédini-Martinez, S Richard, K Ritchie, J P Riso, F Rivier, J M Robine, C Rolland, E Royère, D Sablot, J L Savy, L Schifano, P Senesse, R Sicard, Y Stephan, D Strubel, G Tallon, M Tanfin, H Tassery, I Tavares, K Torre, V Tribout, A Uziel, P Van de Perre, F Venail, C Vergne-Richard, G Vergotte, L Vian, F Vialla, F Viart, M Villain, E Viollet, M Ychou, J Mercier
The Région Languedoc Roussillon is the umbrella organisation for an interconnected and integrated project on active and healthy ageing (AHA). It covers the 3 pillars of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA): (A) Prevention and health promotion, (B) Care and cure, (C) and (D) Active and independent living of elderly people. All sub-activities (poly-pharmacy, falls prevention initiative, prevention of frailty, chronic respiratory diseases, chronic diseases with multimorbidities, chronic infectious diseases, active and independent living and disability) have been included in MACVIA-LR which has a strong political commitment and involves all stakeholders (public, private, patients, policy makers) including CARSAT-LR and the Eurobiomed cluster...
2016: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/27843003/-social-participation-after-childhood-craniopharyngioma
#2
C Olivari-Philiponnet, F Roumenoff, M Schneider, C Chantran, M Picot, P Berlier, C Mottolese, J-C Bernard, C Vuillerot
: Craniopharyngioma is a rare, benign central nervous system tumor, which may be a source of multiple complications, from endocrinology to vision, neurology and neurocognitive functions. This morbidity can lead to reduced participation in life activities, as described in the International Classification of Functioning, Disability, and Health. The primary objective of this study was to measure participation in life activities in a population of children and young adults affected by childhood craniopharyngioma, using the LIFE-H questionnaire (Assessment of Life Habits), validated as a social participation measurement tool in various pediatric disabilities...
November 10, 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/27836875/framing-of-research-question-using-the-picot-format-in-randomised-controlled-trials-of-venous-ulcer-disease-a-protocol-for-a-systematic-survey-of-the-literature
#3
Luciana P F Abbade, Mei Wang, Kamath Sriganesh, Lawrence Mbuagbaw, Lehana Thabane
INTRODUCTION: Although venous ulcers have a great social and economic impact, there is a lack of evidence from randomised controlled trials (RCTs) to support appropriate management for this disease. Framing the research question using the Population; Intervention; Comparator; Outcome; Time frame (PICOT) format in RCTs can improve the quality of the research design. OBJECTIVES: To evaluate how the PICOT format is used to frame a research question in reports of RCTs of venous ulcer disease and to determine the factors associated with better adherence to the PICOT format in framing the research question...
November 11, 2016: BMJ Open
https://www.readbyqxmd.com/read/27801764/tissue-based-immunohistochemical-biomarker-accuracy-in-the-diagnosis-of-malignant-glandular-lesions-of-the-uterine-cervix-a-systematic-review-of-the-literature-and-meta-analysis
#4
Sandra Lee, Marianne S Rose, Vikrant V Sahasrabuddhe, Rachel Zhao, Máire A Duggan
Immunohistochemistry is widely used to support a pathology diagnosis of cervical adenocarcinoma despite the absence of a systematic review and meta-analysis of the published data. This systematic review and meta-analysis was performed to investigate the sensitivity and specificity of immunohistochemistry biomarkers in the tissue-based diagnosis of cervical adenocarcinoma histotypes compared with normal endocervix and benign glandular lesions. The systematic review and meta-analysis used a PICOT framework and QUADAS-2 to evaluate the quality of included studies...
October 31, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27780629/pertussis-biology-epidemiology-and-prevention
#5
Mitra Saadatian-Elahi, Stanley Plotkin, Kingston H G Mills, Scott A Halperin, Peter B McIntyre, Valentina Picot, Jacques Louis, David R Johnson
Despite long-standing vaccination programs, substantial increases in reported cases of pertussis have been described in several countries during the last 5years. Cases among very young infants who are at greatest risk of pertussis-related hospitalizations and mortality are the most alarming. Multiple hypotheses including but not limited to the availability of more sensitive diagnostic tests, greater awareness, and waning vaccine-induced immunity over time have been posited for the current challenges with pertussis...
October 22, 2016: Vaccine
https://www.readbyqxmd.com/read/27779779/direct-sar-mapping-by-thermoacoustic-imaging-a-feasibility-study
#6
Simone A Winkler, Paul A Picot, Michael M Thornton, Brian K Rutt
PURPOSE: To develop a new method capable of directly measuring specific absorption rate (SAR) deposited in tissue using the thermoacoustic signal induced by short radiofrequency (RF) pulse excitation. THEORY: A detailed model based on the thermoacoustic wave generation and propagation is presented. METHODS: We propose a new concept for direct measurement of SAR, to be used as a safety assessment/monitoring tool for MRI. The concept involves the use of short bursts of RF energy and the measurement of the resulting thermoacoustic excitation pattern by an array of ultrasound transducers, followed by image reconstruction to yield the 3D SAR distribution...
October 25, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27742172/the-scalp-hair-collar-and-tuft-signs-a-retrospective-multicenter-study-of-78-patients-with-a-systematic-review-of-the-literature
#7
Didier Bessis, Michèle Bigorre, Nausicaa Malissen, Guillaume Captier, Christine Chiaverini, Claire Abasq, Sébastien Barbarot, Olivia Boccara, Emmanuelle Bourrat, Hassan El Fertit, Catherine Eschard, Thomas Hubiche, Jean-Philippe Lacour, Nicolas Leboucq, Emmanuel Mahé, Stéphanie Mallet, Myriam Marque, Ludovic Martin, Juliette Mazereeuw-Hautier, Nathalie Milla, Alice Phan, Patrice Plantin, Marie-Christine Picot, Eve Puzenat, Valérie Rigau, Pierre Vabres, Sylvie Fraitag, Franck Boralevi
BACKGROUND: Hair collar sign (HCS) and hair tuft of the scalp (HTS) are cutaneous signs of an underlying neuroectodermal defect, but most available data are based on case reports. OBJECTIVE: We sought to define the clinical spectrum of HCS and HTS, clarify the risk for underlying neurovascular anomalies, and provide imaging recommendations. METHODS: A 10-year multicenter retrospective and prospective analysis of clinical, radiologic, and histopathologic features of HCS and HTS in pediatric patients was performed...
October 11, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27692831/7-chloro-4-aminoquinoline-%C3%AE-hydroxy-%C3%AE-lactam-derived-tetramates-as-a-new-family-of-antimalarial-compounds
#8
Nicolas Chopin, Shinya Iikawa, Julien Bosson, Adeline Lavoignat, Guillaume Bonnot, Anne-Lise Bienvenu, Stéphane Picot, Jean-Philippe Bouillon, Maurice Médebielle
In this Letter we report on an efficient and short 2-3 steps synthesis of γ-hydroxy-γ-lactam derived-tetramates bearing a 7-chloro-4-aminoquinoline skeleton and their evaluation as potent antimalarials. These molecules were obtained through ring opening-ring closure (RORC) process of γ-ylidene-tetronate derivatives in the presence of 7-chloro-4-aminoquinoline-derived amines. In vitro antimalarial activity of these new γ-lactams was evaluated against Plasmodium falciparum clones of variable sensitivity (3D7 and W2) and they were found to be active in the range of 14-827nM with generally good resistance index...
September 15, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27692524/report-of-the-cent-gardes-hiv-vaccines-conference-part-2-the-cellular-immune-response-fondation-m%C3%A3-rieux-conference-center-veyrier-du-lac-france-25-27-october-2015
#9
Marc P Girard, Roger Le-Grand, Valentina Picot, Christophe Longuet, Gary J Nabel
No abstract text is available yet for this article.
September 27, 2016: Vaccine
https://www.readbyqxmd.com/read/27659388/-condydav-a-multicentre-observational-study-of-patients-presenting-external-genital-warts-in-france
#10
J Chanal, S Fouéré, F Yassir-Oria, N Spenatto, F Bouscarat, E Picot, P Martinet, C Vernay-Vaisse, F Pelletier, C Courtieu, V Baclet, C Bernier, D Aymar-Moulene, F Dupuis-Fourdan, A Passeron, C Bara-Passot, A-L Pinault, L Misery, M Janier, N Dupin
BACKGROUND: Since 2007 in France, human papilloma virus (HPV) vaccination has been licensed for use as a vaccine against HPV 6, 11, 16 and 18. The impact on the epidemiology of external genital warts (EGWs) in a large population remains unclear. OBJECTIVES: To determine epidemiologic and clinical features of patients presenting EGWs in France in the era of HPV vaccination. PATIENTS AND METHODS: In this prospective, observational study, we analyzed clinical features and treatments between January 1st, 2012 and March 31, 2012 for patients consulting for EGWs at 15 STI clinics throughout France...
September 19, 2016: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/27646701/individual-variation-in-an-acute-stress-response-reflects-divergent-coping-strategies-in-a-large-herbivore
#11
Chloé Monestier, Emmanuelle Gilot-Fromont, Nicolas Morellet, Lucie Debeffe, Nicolas Cebe, Joël Merlet, Denis Picot, Jean-Luc Rames, A J Mark Hewison, Hélène Verheyden
Individuals differ in the manner that they cope with risk. When these behavioral differences are manifested in risky or challenging environments (i.e. stressful situations), they are generally interpreted within the "coping style" framework. As studying inter-individual variability in behavior is particularly challenging in the wild, we used a captive facility to explore consistency in the individual behavioral response to an acute stress in roe deer (Capreolus capreolus). Using behavioral and physiological parameters measured six times across a calendar year, we first quantified individual repeatability and, second, explored the correlations among these parameters that might indicate a coherent stress response...
September 16, 2016: Behavioural Processes
https://www.readbyqxmd.com/read/27617799/three-complementary-approaches-to-characterize-buprenorphine-misuse
#12
Céline Eiden, Erika Nogue, Caroline Diot, Elisabeth Frauger, Emilie Jouanjus, Yves Léglise, Marie-Christine Picot, Hélène Peyriere
BACKGROUND: In France, buprenorphine has been available for opioid maintenance therapy since 1996 and since then its misuse has been continuously evaluated by the French health authorities. OBJECTIVES: To characterize buprenorphine misuse in Languedoc-Roussillon (LR) region, using three different approaches. METHODS: Three different data sources were analyzed : (i) spontaneous reports (NotS) of buprenorphine misuse or dependence, (ii) a specific periodic survey from specialized care centers (OPPIDUM) over 11 years (2002-2012) and (iii) a drug reimbursement database (DRB)...
December 5, 2016: Substance Use & Misuse
https://www.readbyqxmd.com/read/27610839/antiproton-flux-antiproton-to-proton-flux-ratio-and-properties-of-elementary-particle-fluxes-in-primary-cosmic-rays-measured-with-the-alpha-magnetic-spectrometer-on-the-international-space-station
#13
M Aguilar, L Ali Cavasonza, B Alpat, G Ambrosi, L Arruda, N Attig, S Aupetit, P Azzarello, A Bachlechner, F Barao, A Barrau, L Barrin, A Bartoloni, L Basara, S Başeǧmez-du Pree, M Battarbee, R Battiston, J Bazo, U Becker, M Behlmann, B Beischer, J Berdugo, B Bertucci, V Bindi, G Boella, W de Boer, K Bollweg, V Bonnivard, B Borgia, M J Boschini, M Bourquin, E F Bueno, J Burger, F Cadoux, X D Cai, M Capell, S Caroff, J Casaus, G Castellini, I Cernuda, F Cervelli, M J Chae, Y H Chang, A I Chen, G M Chen, H S Chen, L Cheng, H Y Chou, E Choumilov, V Choutko, C H Chung, C Clark, R Clavero, G Coignet, C Consolandi, A Contin, C Corti, B Coste, W Creus, M Crispoltoni, Z Cui, Y M Dai, C Delgado, S Della Torre, M B Demirköz, L Derome, S Di Falco, F Dimiccoli, C Díaz, P von Doetinchem, F Dong, F Donnini, M Duranti, D D'Urso, A Egorov, A Eline, T Eronen, J Feng, E Fiandrini, E Finch, P Fisher, V Formato, Y Galaktionov, G Gallucci, B García, R J García-López, C Gargiulo, H Gast, I Gebauer, M Gervasi, A Ghelfi, F Giovacchini, P Goglov, D M Gómez-Coral, J Gong, C Goy, V Grabski, D Grandi, M Graziani, I Guerri, K H Guo, M Habiby, S Haino, K C Han, Z H He, M Heil, J Hoffman, T H Hsieh, H Huang, Z C Huang, C Huh, M Incagli, M Ionica, W Y Jang, H Jinchi, S C Kang, K Kanishev, G N Kim, K S Kim, Th Kirn, C Konak, O Kounina, A Kounine, V Koutsenko, M S Krafczyk, G La Vacca, E Laudi, G Laurenti, I Lazzizzera, A Lebedev, H T Lee, S C Lee, C Leluc, H S Li, J Q Li, J Q Li, Q Li, T X Li, W Li, Z H Li, Z Y Li, S Lim, C H Lin, P Lipari, T Lippert, D Liu, Hu Liu, S Q Lu, Y S Lu, K Luebelsmeyer, F Luo, J Z Luo, S S Lv, R Majka, C Mañá, J Marín, T Martin, G Martínez, N Masi, D Maurin, A Menchaca-Rocha, Q Meng, D C Mo, L Morescalchi, P Mott, T Nelson, J Q Ni, N Nikonov, F Nozzoli, P Nunes, A Oliva, M Orcinha, F Palmonari, C Palomares, M Paniccia, M Pauluzzi, S Pensotti, R Pereira, N Picot-Clemente, F Pilo, C Pizzolotto, V Plyaskin, M Pohl, V Poireau, A Putze, L Quadrani, X M Qi, X Qin, Z Y Qu, T Räihä, P G Rancoita, D Rapin, J S Ricol, I Rodríguez, S Rosier-Lees, A Rozhkov, D Rozza, R Sagdeev, J Sandweiss, P Saouter, S Schael, S M Schmidt, A Schulz von Dratzig, G Schwering, E S Seo, B S Shan, J Y Shi, T Siedenburg, D Son, J W Song, W H Sun, M Tacconi, X W Tang, Z C Tang, L Tao, D Tescaro, Samuel C C Ting, S M Ting, N Tomassetti, J Torsti, C Türkoğlu, T Urban, V Vagelli, E Valente, C Vannini, E Valtonen, M Vázquez Acosta, M Vecchi, M Velasco, J P Vialle, V Vitale, S Vitillo, L Q Wang, N H Wang, Q L Wang, X Wang, X Q Wang, Z X Wang, C C Wei, Z L Weng, K Whitman, J Wienkenhöver, M Willenbrock, H Wu, X Wu, X Xia, R Q Xiong, W Xu, Q Yan, J Yang, M Yang, Y Yang, H Yi, Y J Yu, Z Q Yu, S Zeissler, C Zhang, J Zhang, J H Zhang, S D Zhang, S W Zhang, Z Zhang, Z M Zheng, Z Q Zhu, H L Zhuang, V Zhukov, A Zichichi, N Zimmermann, P Zuccon
A precision measurement by AMS of the antiproton flux and the antiproton-to-proton flux ratio in primary cosmic rays in the absolute rigidity range from 1 to 450 GV is presented based on 3.49×10^{5} antiproton events and 2.42×10^{9} proton events. The fluxes and flux ratios of charged elementary particles in cosmic rays are also presented. In the absolute rigidity range ∼60 to ∼500  GV, the antiproton p[over ¯], proton p, and positron e^{+} fluxes are found to have nearly identical rigidity dependence and the electron e^{-} flux exhibits a different rigidity dependence...
August 26, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27595433/cost-effectiveness-analysis-of-epilepsy-surgery-in-a-controlled-cohort-of-adult-patients-with-intractable-partial-epilepsy-a-5-year-follow-up-study
#14
Marie-Christine Picot, Audrey Jaussent, Dorine Neveu, Philippe Kahane, Arielle Crespel, Philippe Gelisse, Edouard Hirsch, Philippe Derambure, Sophie Dupont, Elizabeth Landré, Francine Chassoux, Luc Valton, Jean-Pierre Vignal, Cécile Marchal, Catherine Lamy, Franck Semah, Arnaud Biraben, Alexis Arzimanoglou, Jérôme Petit, Pierre Thomas, Valérie Macioce, Pierre Dujols, Philippe Ryvlin
OBJECTIVE: Despite its well-known effectiveness, the cost-effectiveness of epilepsy surgery has never been demonstrated in France. We compared cost-effectiveness between resective surgery and medical therapy in a controlled cohort of adult patients with partial intractable epilepsy. METHODS: A prospective cohort of adult patients with surgically remediable and medically intractable partial epilepsy was followed over 5 years in the 15 French centers. Effectiveness was defined as 1 year without a seizure, based on the International League Against Epilepsy (ILAE) classification...
October 2016: Epilepsia
https://www.readbyqxmd.com/read/27588817/active-bleeding-after-cardiac-surgery-a-prospective-observational-multicenter-study
#15
Pascal H Colson, Philippe Gaudard, Jean-Luc Fellahi, Héléna Bertet, Marie Faucanie, Julien Amour, Yvonnick Blanloeil, Hervé Lanquetot, Alexandre Ouattara, Marie Christine Picot
MAIN OBJECTIVES: To estimate the incidence of active bleeding after cardiac surgery (AB) based on a definition directly related on blood flow from chest drainage; to describe the AB characteristics and its management; to identify factors of postoperative complications. METHODS: AB was defined as a blood loss > 1.5 ml/kg/h for 6 consecutive hours within the first 24 hours or in case of reoperation for hemostasis during the first 12 postoperative hours. The definition was applied in a prospective longitudinal observational study involving 29 French centers; all adult patients undergoing cardiac surgery with cardiopulmonary bypass were included over a 3-month period...
2016: PloS One
https://www.readbyqxmd.com/read/27567410/kerion-celsi-caused-by-microsporum-gypseum
#16
Gautier Hoarau, Juliette Miquel, Sandrine Picot
No abstract text is available yet for this article.
August 24, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27541488/in-situ-exfoliation-of-graphene-in-epoxy-resins-a-facile-strategy-to-efficient-and-large-scale-graphene-nanocomposites
#17
Yan Li, Han Zhang, Maria Crespo, Harshit Porwal, Olivier Picot, Giovanni Santagiuliana, Zhaohui Huang, Ettore Barbieri, Nicola M Pugno, Ton Peijs, Emiliano Bilotti
Any industrial application aiming at exploiting the exceptional properties of graphene in composites or coatings is currently limited by finding viable production methods for large volumes of good quality and high aspect ratio graphene, few layer graphene (FLG) or graphite nanoplatelets (GNP). Final properties of the resulting composites are inherently related to those of the initial graphitic nanoparticles, which typically depend on time-consuming, resource-demanding and/or low yield liquid exfoliation processes...
September 14, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27500748/groundwater-contamination-in-coastal-urban-areas-anthropogenic-pressure-and-natural-attenuation-processes-example-of-recife-pe-state-ne-brazil
#18
G Bertrand, R Hirata, H Pauwels, L Cary, E Petelet-Giraud, E Chatton, L Aquilina, T Labasque, V Martins, S Montenegro, J Batista, A Aurouet, J Santos, R Bertolo, G Picot, M Franzen, R Hochreutener, G Braibant
In a context of increasing land use pressure (over-exploitation, surface-water contamination) and repeated droughts, identifying the processes affecting groundwater quality in coastal megacities of the tropical and arid countries will condition their long-term social and environmental sustainability. The present study focuses on the Brazilian Recife Metropolitan Region (RMR), which is a highly urbanized area (3,743,854 inhabitants in 2010) on the Atlantic coast located next to an estuarial zone and overlying a multi-layered sedimentary system featured by a variable sediment texture and organic content...
September 2016: Journal of Contaminant Hydrology
https://www.readbyqxmd.com/read/27495574/-not-available
#19
M Cachera, M Lagrange-Xélot, L Bellec, M Moiton, R Manaquin, S Picot, A Lignereux, I Degasne
No abstract text is available yet for this article.
June 2016: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/27495573/-not-available
#20
A Bertolotti, P Gerardin, N Zemali, R Manaquin, G Borgherini, A Foucher, S Picot, J Jaubert, P Poubeau, G Camuset
No abstract text is available yet for this article.
June 2016: Médecine et Maladies Infectieuses
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