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https://www.readbyqxmd.com/read/29772456/new-insights-into-the-in-vitro-biological-effects-in-silico-docking-and-chemical-profile-of-clary-sage-salvia-sclarea-l
#1
Gokhan Zengin, Ismail Senkardes, Adriano Mollica, Carene Marie Nancy Picot-Allain, Gizem Bulut, Ahmet Dogan, M Fawzi Mahomoodally
Salvia sclarea L. is traditionally used to manage common human ailments and is consumed as a food product. This study aimed to establish the phytochemical profile and antioxidant potential of ethyl acetate, methanol, and water extracts of Salvia sclarea. The inhibitory action of the extracts against α-amylase, α-glucosidase, acetylcholinesterase, butyrylcholinesterase, and tyrosinase was also investigated. Methanol extract showed the highest phenolic and flavonoid contents (81.78 mg GAE/g extract and 40...
May 6, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29760130/-mycobacterium-simiae-clinical-radiological-and-microbiological-characteristics-in-97-patients
#2
Nathalie Coolen-Allou, Thomas Touron, Olivier Belmonte, Virgile Gazaille, Michel Andre, Jérôme Allyn, Sandrine Picot, Annabelle Payet, Nicolas Veziris
Mycobacterium simiae is a rare species of slow-growing nontuberculous mycobacteria (NTM).From 2002 to 2017, we conducted a retrospective study that included all patients with NTM-positive respiratory samples detected in two university hospitals of the French overseas department of Reunion Island. We recorded the prevalence of M. simiae in this cohort, as well as the clinical, radiological, and microbiological features of patients with at least one sample positive for M. simiae In our cohort, 97 patients (15...
May 14, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29753529/candidemia-in-the-intensive-care-unit-a-12-year-retrospective-cohort-study-in-reunion-island
#3
G Hoarau, S Picot, J Lemant, J Peytral, P Poubeau, P Zunic, C Mohr, X Coueffe, P Gerardin, E Antok
OBJECTIVES: We aimed to describe the epidemiology of Candida bloodstream infection in an intensive care unit (ICU) in Reunion Island. METHODS: We performed a retrospective cohort study and evaluated 63 candidemia episodes, which occurred between January 2004 and December 2015 in the ICU of a University Hospital in St-Pierre. RESULTS: The incidence rate of candidemia in the ICU was estimated at 7.6%. Candida albicans was the most common yeast pathogen species recovered (54%), followed by Candida glabrata (17%), Candida tropicalis (12%) and Candida parapsilosis (10%)...
May 9, 2018: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29735100/multidirectional-investigations-on-different-parts-of-allium-scorodoprasum-l-subsp-rotundum-l-stearn-phenolic-components-in-vitro-biological-and-in-silico-propensities
#4
Adriano Mollica, Gokhan Zengin, Marcello Locatelli, Carene Marie Nancy Picot-Allain, Mohamad Fawzi Mahomoodally
Allium species have been widely used for culinary and medicinal purposes. This study attempts for the first time to investigate into the enzyme inhibitory potential of different plant parts of Allium scorodoprasum L. subsp. rotundum (L.) Stearn, also known as wild garlic or leek in Turkey. The antioxidant and enzyme inhibitory potential of the flower, stem, and bulb extracts of A. scorodoprasum were assessed using in vitro bio-assays. The phenolic composition of the different plant parts was also established...
June 2018: Food Research International
https://www.readbyqxmd.com/read/29728591/association-between-amniotic-fluid-evaluation-and-fetal-biometry-a-prospective-french-flash-study
#5
Florent Fuchs, Safa Aouinti, Manel Souaied, Valentin Keller, Marie-Christine Picot, Nicolas Fries, Jean-Marc Ayoubi, Olivier Picone
We aimed to study the association between three different methods of assessing the amount of amniotic fluid (subjective method (SM), deepest vertical pocket (DVP) and amniotic fluid index (AFI)) and estimated fetal weight (EFW) (in percentile or Z-score) after adjustment on maternal-fetal parameters. We performed a nationwide cross-sectional study through the French network of obstetric sonographers using the "flash" study method and including low-risk singleton pregnancies from 18-40 weeks. Crude and adjusted odds ratio were computed after stratification upon 2nd and 3rd trimester of pregnancy...
May 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29717154/dietary-environmental-and-genetic-risk-factors-of-extensive-macular-atrophy-with-pseudodrusen-a-severe-bilateral-macular-atrophy-of-middle-aged-patients
#6
Aymeric Douillard, Marie-Christine Picot, Cécile Delcourt, Sabine Defoort-Dhellemmes, Nour Al-Dain Marzouka, Annie Lacroux, Xavier Zanlonghi, Isabelle Drumare, Elsa Jozefowicz, Béatrice Bocquet, Corinne Baudoin, Sarah Perez-Roustit, Sophie Arsène, Valérie Gissot, François Devin, Carl Arndt, Benjamin Wolff, Martine Mauget-Faÿsse, Maddalena Quaranta, Thibault Mura, Dominique Deplanque, Hassiba Oubraham, Salomon Yves Cohen, Pierre Gastaud, Olivia Zambrowski, Catherine Creuzot-Garcher, Saddek Mohand Saïd, José-Alain Sahel, Eric Souied, Solange Milazzo, Rocio Blanco Garavito, Vasiliki Kalatzis, Bernard Puech, Christian Hamel, Isabelle Audo, Isabelle Meunier
EMAP (Extensive Macular Atrophy with Pseudodrusen) is a maculopathy we recently described that shares pseudodrusen and geographic atrophy with Age-related Macular Disease (AMD). EMAP differs from AMD by an earlier age of onset (50-55 years) and a characteristic natural history comprising a night blindness followed by a severe visual loss. In a prospective case-control study, ten referral centers included 115 EMAP (70 women, 45 men) patients and 345 matched controls to appraise dietary, environmental, and genetic risk factors...
May 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29707521/evaluation-by-flow-cytometry-of-mature-monocyte-subpopulations-for-the-diagnosis-and-follow-up-of-chronic-myelomonocytic-leukemia
#7
Tiphanie Picot, Carmen Mariana Aanei, Pascale Flandrin Gresta, Pauline Noyel, Sylvie Tondeur, Emmanuelle Tavernier Tardy, Denis Guyotat, Lydia Campos Catafal
Chronic myelomonocytic leukemia (CMML) is a myelodysplastic/myeloproliferative neoplasm, characterized by persistent monocytosis and dysplasia in at least one myeloid cell lineage. This persistent monocytosis should be distinguished from the reactive monocytosis which is sometimes observed in a context of infections or solid tumors. In 2015, Selimoglu-Buet et al. observed an increased percentage of classical monocytes (CD14+ /CD16- >94%) in the peripheral blood (PB) of CMML patients. In this study, using multiparametric flow cytometry (MFC), we assessed the monocytic distribution in PB samples and in bone marrow aspirates from 63 patients with monocytosis or CMML suspicion, and in seven follow-up blood samples from CMML patients treated with hypomethylating agents (HMA)...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29681463/-fungal-keratitis-a-5-year-monocentric-retrospective-study-on-reunion-island
#8
G Hoarau, M Albrieux, T Martin-Phipps, K Zitte-Zehler, L Borry, J Peytral, D Garcia-Hermoso, S Picot
OBJECTIVES: Fungal keratitis is rare in France, but could be a severe sight-threatening condition. Here, we aimed to describe the epidemiology of fungal keratitis in Réunion Island. METHODS: In a retrospective study, we analyzed 13 culture-proven keratitis episodes, occurred between January 2013 and July 2017 in the ophthalmology ward of a University Hospital, Saint-Pierre. Twelve isolates were genotyped and antifungal susceptibility testing was performed. RESULTS: Corneal abrasion caused by vegetable matter was the main predisposing factor...
April 19, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29663903/burden-of-influenza-in-less-than-5-year-old-children-admitted-to-hospital-with-pneumonia-in-developing-and-emerging-countries-a-descriptive-multicenter-study
#9
Cédric Dananché, Valentina Sánchez Picot, Thomas Bénet, Mélina Messaoudi, Monidarin Chou, Jianwei Wang, Jean-William Pape, Shally Awasthi, Ashish Bavdekar, Mala Rakoto-Andrianarivelo, Mariam Sylla, Pagbajabyn Nymadawa, Graciela Russomando, Florence Komurian-Pradel, Hubert Endtz, Gláucia Paranhos-Baccalà, Philippe Vanhems, On Behalf Of The Pneumonia Gabriel Network
This descriptive 4-year study reports the proportion of detection of influenza viruses in less than 5-year-old children hospitalized for pneumonia in eight developing and emerging countries and describes clinical and microbiological characteristics of influenza-related pneumonia cases. Hospitalized children presenting radiologically confirmed pneumonia aged 2-60 months were prospectively enrolled in this observational standardized study. Mean proportion of isolated influenza virus was 9.7% (95% confidence interval: 7...
April 16, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29661195/impact-of-patient-involvement-on-clinical-practice-guideline-development-a-parallel-group-study
#10
Melissa J Armstrong, C Daniel Mullins, Gary S Gronseth, Anna R Gagliardi
BACKGROUND: Patient and public involvement (PPI) is recognized as a key component of clinical practice guideline development with important implications for guideline implementability. The impact of PPI on guidelines, however, has not been rigorously assessed. Better understanding of the impact of PPI must start with guideline question formation, which drives all subsequent development steps. The aim of this study was to investigate the effect of PPI on guideline question formation and validate a conceptual model of patient and public contributions to guidelines...
April 16, 2018: Implementation Science: IS
https://www.readbyqxmd.com/read/29656841/from-phaeohyphomycosis-to-disseminated-chromoblastomycosis-a-retrospective-study-of-infections-caused-by-dematiaceous-fungi
#11
E Thomas, A Bertolotti, A Barreau, J Klisnick, P Tournebize, G Borgherini, N Zemali, J Jaubert, G Jouvion, S Bretagne, S Picot
OBJECTIVE: Infections caused by dematiaceous fungi are more common in tropical and subtropical areas. We aimed to describe the clinical, microbiological and therapeutic aspects of case patients diagnosed at a University Hospital located on an Indian Ocean island. PATIENTS AND METHODS: We performed an observational retrospective study of infections caused by dematiaceous fungi diagnosed at the University Hospital of Saint-Pierre, Reunion, from 2000 to 2015. Mycological identifications were performed at the National Reference Center for Invasive Mycosis and Antifungal Agents (Paris)...
April 12, 2018: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29582000/rhythmic-abilities-and-musical-training-in-parkinson-s-disease-do-they-help
#12
V Cochen De Cock, D G Dotov, P Ihalainen, V Bégel, F Galtier, C Lebrun, M C Picot, V Driss, N Landragin, C Geny, B Bardy, S Dalla Bella
Rhythmic auditory cues can immediately improve gait in Parkinson's disease. However, this effect varies considerably across patients. The factors associated with this individual variability are not known to date. Patients' rhythmic abilities and musicality (e.g., perceptual and singing abilities, emotional response to music, and musical training) may foster a positive response to rhythmic cues. To examine this hypothesis, we measured gait at baseline and with rhythmic cues in 39 non-demented patients with Parkinson's disease and 39 matched healthy controls...
2018: NPJ Parkinson's Disease
https://www.readbyqxmd.com/read/29576532/structural-insights-into-the-forward-and-reverse-enzymatic-reactions-in-human-adenine-phosphoribosyltransferase
#13
Jessica Huyet, Mohammad Ozeir, Marie-Claude Burgevin, Benoît Pinson, Françoise Chesney, Jean-Marc Remy, Abdul Rauf Siddiqi, Roland Lupoli, Gregory Pinon, Christelle Saint-Marc, Jean-Francois Gibert, Renaud Morales, Irène Ceballos-Picot, Robert Barouki, Bertrand Daignan-Fornier, Anne Olivier-Bandini, Franck Augé, Pierre Nioche
Phosphoribosyltransferases catalyze the displacement of a PRPP α-1'-pyrophosphate to a nitrogen-containing nucleobase. How they control the balance of substrates/products binding and activities is poorly understood. Here, we investigated the human adenine phosphoribosyltransferase (hAPRT) that produces AMP in the purine salvage pathway. We show that a single oxygen atom from the Tyr105 side chain is responsible for selecting the active conformation of the 12 amino acid long catalytic loop. Using in vitro, cellular, and in crystallo approaches, we demonstrated that Tyr105 is key for the fine-tuning of the kinetic activity efficiencies of the forward and reverse reactions...
March 16, 2018: Cell Chemical Biology
https://www.readbyqxmd.com/read/29504059/influence-of-a-brisk-walking-program-on-postural-responses-in-sedentary-older-women-a-randomised-trial
#14
P L Bernard, H Blain, G Tallon, G Ninot, A Jaussent, M C Picot, C Belloc, O Coste, J Bousquet, S Ramdani
This study analyzes the evolution in kinematic and non-linear stabilometric parameters in elderly sedentary women selected to participate in a brisk walking program. Ninety-four women were randomly selected for a program of 78 sessions over 6 months, with three sessions of 60 min per week. On the force platform, participants were assessed with both eyes opened as well as eyes closed during a period of 51.2 s and the sampling frequency was 40 Hz. The main dependent kinematic variables were the length, stabilogram surface, and the mean position in anteroposterior as well as medio-lateral directions...
May 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29498256/biabooster-online-dna-concentration-and-size-profiling-with-a-limit-of-detection-of-10-fg-%C3%AE-l-and-application-to-high-sensitivity-characterization-of-circulating-cell-free-dna
#15
Comtet-Louis Andriamanampisoa, Aurélien Bancaud, Audrey Boutonnet-Rodat, Audrey Didelot, Jacques Fabre, Frédéric Fina, Fanny Garlan, Sonia Garrigou, Caroline Gaudy, Frédéric Ginot, Daniel Henaff, Pierre Laurent-Puig, Arnaud Morin, Vincent Picot, Laure Saias, Valérie Taly, Pascale Tomasini, Aziz Zaanan
We describe a technology to perform sizing and concentration analysis of double stranded DNA with a sensitivity of 10 fg/μL in an operating time of 20 min. The technology is operated automatically on a commercial capillary electrophoresis instrument using electro-hydrodynamic actuation. It relies on a new capillary device that achieves online concentration of DNA at the junction between two capillaries of different diameters, thanks to viscoelastic lift forces. Using a set of DNA ladders in the range of 100-1500 bp, we report a sizing accuracy and precision better than 3% and a concentration quantification precision of ∼20%...
March 20, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29477093/in-vitro-and-in-silico-evaluation-of-centaurea-saligna-k-koch-wagenitz-an-endemic-folk-medicinal-plant
#16
Gokhan Zengin, Gizem Bulut, Adriano Mollica, Carene Marie Nancy Picot-Allain, Mohamad Fawzi Mahomoodally
Centaurea saligna (K.Koch) Wagenitz is an endemic plant used in Turkish folk medicine as antibacterial, tonic, astringent, choleretic, anti-rheumatic, diuretic, and antipyretic. This study attempts for the first time to assess the possible enzyme inhibitory potential, antioxidant activity, and determine the phytochemical profile of the ethyl acetate, methanol, and water extracts of C. saligna. The water extract had the highest phenolic content (30.18 mg GAE/g extract) and the most potent oxidant scavenging activity ((120...
April 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29476786/sensitization-of-tumor-cells-to-chemotherapy-by-natural-products-a-systematic-review-of-preclinical-data-and-molecular-mechanisms
#17
REVIEW
Raimundo Gonçalves de Oliveira Júnior, Alves Ferraz Christiane Adrielly, Jackson Roberto Guedes da Silva Almeida, Raphaël Grougnet, Valérie Thiéry, Laurent Picot
PURPOSE: Tumor cells are spontaneously or adaptively resistant to chemotherapeutic drugs, eventually leading to the selection of multiresistant cells responsible for tumor growth and metastasis. Chemosensitization of tumor cells to conventional drugs using non-toxic natural products is a recent and innovative strategy aiming to increase the cytotoxic efficiency of anticancer drugs, limit their toxic side effects and delay the appearance of acquired chemoresistance. This systematic review summarizes data obtained from preclinical studies reporting the use of natural products to sensitize tumor cells to chemotherapeutic agents...
February 21, 2018: Fitoterapia
https://www.readbyqxmd.com/read/29463056/a-comparative-assessment-of-biological-effects-and-chemical-profile-of-italian-asphodeline-lutea-extracts
#18
Dora Melucci, Marcello Locatelli, Clinio Locatelli, Alessandro Zappi, Francesco De Laurentiis, Simone Carradori, Cristina Campestre, Lidia Leporini, Gokhan Zengin, Carene Marie Nancy Picot, Luigi Menghini, Mohamad Fawzi Mahomoodally
The present study aims to highlight the therapeutic potential of Asphodeline lutea ( AL ), a wild edible plant of the Mediterranean diet. Roots, aerial parts, and flowers of AL at two different phenological stages were collected from three locations in Italy. The inhibitory activities of extracts on strategic enzymes linked to human diseases were assessed. The antioxidant properties were evaluated in vitro, using six standard bioassays. The phenolic and anthraquinone profiles were also established using HPLC-PDA...
February 19, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29449287/global-influenza-hospital-based-surveillance-network-gihsn-results-of-surveillance-of-influenza-and-other-respiratory-viruses-in-hospitalised-patients-in-brazil-2015
#19
Sonia M Raboni, Fernanda E A Moura, Braulia C Caetano, Valéria M Avanzi, Luciane A Pereira, Meri B Nogueira, Luine R Vidal, Isabel C F Tavares, Florence K Pradel, Valentina S Picot, Joan Puig-Barbera, Marilda M Siqueira
BACKGROUND: Influenza-like illness occurs annually worldwide, with peak timing and severity varying seasonally, resulting in significant annual mortality. OBJECTIVES: There were three objectives: (1) to describe the epidemiological and clinical features of hospitalised patients with severe acute respiratory infection caused by influenza and other respiratory viruses (ORVs); (2) to report the influenza seasonality in the region and (3) to correlate findings of influenza circulation and immunisation time in Brazil...
February 15, 2018: BMJ Open
https://www.readbyqxmd.com/read/29433429/the-management-of-children-with-bronchiolitis-in-the-australasian-hospital-setting-development-of-a-clinical-practice-guideline
#20
Sharon O'Brien, Sally Wilson, Fenella J Gill, Elizabeth Cotterell, Meredith L Borland, Edward Oakley, Stuart R Dalziel
BACKGROUND: Bronchiolitis is the commonest respiratory infection in children less than 12 months and cause of hospitalisation in infants under 6 months of age in Australasia. Unfortunately there is substantial variation in management, despite high levels of supporting evidence. This paper reports on the process, strengths and challenges of the hybrid approach used to develop the first Australasian management guideline relevant to the local population. METHOD: An adaption of the nine steps recommended by the National Health and Medical Research Council (NHMRC) and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology were utilised...
February 12, 2018: BMC Medical Research Methodology
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