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https://www.readbyqxmd.com/read/29055128/a-generalized-outflow-boundary-condition-impedance-model-for-non-invasive-prediction-of-ischemia-in-diseased-coronary-arteries
#1
Iyad A Fayssal, Fadl Moukalled, Samir Alam, Hussain Isma'eel
This paper reports on a new boundary condition formulation to model the total coronary myocardial flow and impedance characteristics of the myocardial vascular bed for any specific patient when considered for non-invasive diagnosis of fractional flow reserve (FFR). The developed boundary condition model inherits an implicit representation of the downstream truncated vascular bed and is based on integrating patient-specific physiologic parameters that can be non-invasively extracted for each patient to account for blood flow demand to the myocardium at rest and hyperemic conditions...
October 21, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29055058/the-neural-oscillations-of-speech-processing-and-language-comprehension-state-of-the-art-and-emerging-mechanisms
#2
Lars Meyer
Neural oscillations subserve a broad range of functions in speech processing and language comprehension. On the one hand, speech contains-somewhat-repetitive trains of air pressure bursts that occur at three dominant amplitude modulation frequencies, physically marking the linguistically meaningful progressions of phonemes, syllables, and intonational phrase boundaries. To these acoustic events, neural oscillations of isomorphous operating frequencies are thought to synchronize, presumably resulting in an implicit temporal alignment of periods of neural excitability to linguistically meaningful spectral information on the three low-level linguistic description levels...
October 20, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29054291/neuroscience-informed-psychoeducation-for-addiction-medicine-a-neurocognitive-perspective
#3
Hamed Ekhtiari, Tara Rezapour, Robin L Aupperle, Martin P Paulus
Psychoeducation (PE) is defined as an intervention with systematic, structured, and didactic knowledge transfer for an illness and its treatment, integrating emotional and motivational aspects to enable patients to cope with the illness and to improve its treatment adherence and efficacy. PE is considered an important component of treatment in both medical and psychiatric disorders, especially for mental health disorders associated with lack of insight, such as alcohol and substance use disorders (ASUDs). New advancements in neuroscience have shed light on how various aspects of ASUDs may relate to neural processes...
2017: Progress in Brain Research
https://www.readbyqxmd.com/read/29053462/implicit-block-diagonal-low-rank-representation
#4
Xingyu Xie, Xianglin Guo, Guangcan Liu, Jun Wang
While current block diagonal constrained subspace clustering methods are performed explicitly on the original data space, in practice it is often more desirable to embed the block diagonal prior into the reproducing kernel Hilbert feature space by kernelization techniques, as the underlying data structure in reality is usually nonlinear. However, it is still unknown how to carry out the embedding and kernelization in the models with block diagonal constraints. In this work, we shall take a step in this direction...
October 17, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/29053254/a-versatile-tool-for-the-analysis-of-metal-protein-interactions-reveals-the-promiscuity-of-metallodrug-protein-interactions
#5
Ronald Fook Seng Lee, Laure Menin, Luc Patiny, Daniel Ortiz, Paul J Dyson
Metallodrug-protein interactions contribute to their therapeutic effect (even when DNA is the dominant target), side-effects and are implicit in drug resistance. Here, we provide mass spectrometric-based evidence to show that metallodrug interactions with proteins are considerably more complex than current literature would suggest. Using native incubation and electrospray conditions together with an automated tool we designed for exhaustive mass spectra matching, the promiscuity of binding of cisplatin to ubiquitin is revealed, with 14 different binding sites observed...
October 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29052166/is-human-classification-by-experienced-untrained-observers-a-gold-standard-in-fixation-detection
#6
Ignace T C Hooge, Diederick C Niehorster, Marcus Nyström, Richard Andersson, Roy S Hessels
Manual classification is still a common method to evaluate event detection algorithms. The procedure is often as follows: Two or three human coders and the algorithm classify a significant quantity of data. In the gold standard approach, deviations from the human classifications are considered to be due to mistakes of the algorithm. However, little is known about human classification in eye tracking. To what extent do the classifications from a larger group of human coders agree? Twelve experienced but untrained human coders classified fixations in 6 min of adult and infant eye-tracking data...
October 19, 2017: Behavior Research Methods
https://www.readbyqxmd.com/read/29051937/molecular-dynamics-simulations-of-%C3%AE-2-microglobulin-interaction-with-hydrophobic-surfaces
#7
Cedrix J Dongmo Foumthuim, Alessandra Corazza, Gennaro Esposito, Federico Fogolari
Hydrophobic surfaces are known to adsorb and unfold proteins, a process that has been studied only for a few proteins. Here we address the interaction of β2-microglobulin, a paradigmatic protein for the study of amyloidogenesis, with hydrophobic surfaces. A system with 27 copies of the protein surrounded by a model cubic hydrophobic box is studied by implicit solvent molecular dynamics simulations. Most proteins adsorb on the walls of the box without major distortions in local geometry, whereas free molecules maintain proper structures and fluctuations as observed in explicit solvent molecular dynamics simulations...
October 20, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/29051694/implicit-and-explicit-iterative-algorithms-for-hierarchical-variational-inequality-in-uniformly-smooth-banach-spaces
#8
Lu-Chuan Ceng, Yung-Yih Lur, Ching-Feng Wen
The purpose of this paper is to solve the hierarchical variational inequality with the constraint of a general system of variational inequalities in a uniformly convex and 2-uniformly smooth Banach space. We introduce implicit and explicit iterative algorithms which converge strongly to a unique solution of the hierarchical variational inequality problem. Our results improve and extend the corresponding results announced by some authors.
2017: Journal of Inequalities and Applications
https://www.readbyqxmd.com/read/29051112/in-vivo-and-in-silico-evaluation-of-a-new-nitric-oxide-donor-s-s-dinitrosobucillamine
#9
Marie-Lynda Bouressam, Benjamin Meyer, Ariane Boudier, Igor Clarot, Pierre Leroy, Alessandro Genoni, Manuel Ruiz-Lopez, Philippe Giummelly, Patrick Liminana, Valérie Salgues, Mostafa Kouach, Caroline Perrin-Sarrado, Isabelle Lartaud, François Dupuis
PURPOSE: In a previous work, we have synthetized a new dinitrosothiol, i.e. S,S'-dinitrosobucillamine BUC(NO)2 combining S-nitroso-N-acetylpenicillamine (SNAP) and S-nitroso-N-acetylcysteine (NACNO) in its structure. When exposed to isolated aorta, we observed a 1.5-fold increase of (•)NO content and a more potent vasorelaxation (1 log higher pD2) compared to NACNO and SNAP alone or combined (Dahboul et al., 2014). In the present study, we analyzed the thermodynamics and kinetics for the release of (•)NO through computational modeling techniques and correlated it to plasma assays...
October 16, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29049731/factors-affecting-mydriasis-free-flicker-ergs-recorded-with-real-time-correction-for-retinal-illuminance-study-of-150-young-healthy-subjects
#10
Kumiko Kato, Mineo Kondo, Ryunosuke Nagashima, Asako Sugawara, Masahiko Sugimoto, Hisashi Matsubara, Daphne L McCulloch, Kengo Ikesugi
Purpose: A small, full-field flicker electroretinogram (ERG) recording system was recently developed to record flicker ERGs without mydriasis (RETeval). The device delivers a stimulus with constant retinal illuminance by adjusting the retinal luminance to compensate for changes in the pupillary area. The purpose of this study was to determine what factors affect the fundamental components of the flicker ERGs recorded by RETeval in young healthy subjects. Methods: Flicker ERGs were recorded with the RETeval system from 150 eyes of 150 young healthy subjects (age, 20-29 years)...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29049595/to-search-or-to-like-mapping-fixations-to-differentiate-two-forms-of-incidental-scene-memory
#11
Kyoung Whan Choe, Omid Kardan, Hiroki P Kotabe, John M Henderson, Marc G Berman
We employed eye-tracking to investigate how performing different tasks on scenes (e.g., intentionally memorizing them, searching for an object, evaluating aesthetic preference) can affect eye movements during encoding and subsequent scene memory. We found that scene memorability decreased after visual search (one incidental encoding task) compared to intentional memorization, and that preference evaluation (another incidental encoding task) produced better memory, similar to the incidental memory boost previously observed for words and faces...
October 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/29048976/healthy-out-group-members-are-represented-psychologically-as-infected-in-group-members
#12
Michael Bang Petersen
A range of studies have demonstrated that people implicitly treat out-groups as the carriers of pathogens and that considerable prejudice against out-groups is driven by concerns about pathogens. Yet the psychological categories that are involved and the selection pressures that underlie these categories remain unclear. A common view is that human pathogen-avoidance psychology is specifically adapted to avoid out-groups because of their potentially different pathogens. However, the series of studies reported here shows that there is no dedicated category for reasoning about out-groups in terms of pathogens...
October 1, 2017: Psychological Science
https://www.readbyqxmd.com/read/29048954/the-cumulative-probability-of-arrest-by-age-28-years-in-the-united-states-by-disability-status-race-ethnicity-and-gender
#13
Erin J McCauley
OBJECTIVES: To estimate the cumulative probability (c) of arrest by age 28 years in the United States by disability status, race/ethnicity, and gender. METHODS: I estimated cumulative probabilities through birth cohort life tables with data from the National Longitudinal Survey of Youth, 1997. RESULTS: Estimates demonstrated that those with disabilities have a higher cumulative probability of arrest (c = 42.65) than those without (c = 29...
October 19, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/29048376/new-methods-of-esterification-of-nanodiamonds-in-fighting-breast-cancer-a-density-functional-theory-approach
#14
Linda-Lucila Landeros-Martinez, Daniel Glossman-Mitnik, Erasmo Orrantia-Borunda, Norma Flores-Holguín
The use of nanodiamonds as anticancer drug delivery vehicles has received much attention in recent years. In this theoretical paper, we propose using different esterification methods for nanodiamonds. The monomers proposed are 2-hydroxypropanal, polyethylene glycol, and polyglicolic acid. Specifically, the hydrogen bonds, infrared (IR) spectra, molecular polar surface area, and reactivity parameters are analyzed. The monomers proposed for use in esterification follow Lipinski's rule of five, meaning permeability is good, they have good permeation, and their bioactivity is high...
October 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29045666/quality-improvement-feature-series-article-4-advanced-designs-for-quality-improvement-studies
#15
Lilliam Ambroggio, Amanda Schondelmeyer, Erik Hoefgen, Patrick Brady, Erin Shaughnessy
Each quality improvement (QI) project has an implicit study design, although these designs are not discussed as commonly as they are in clinical research. Most QI projects fall under the quasi-experimental study category, in which observations are made before and after the implementation of an intervention(s). The simplest and most commonly used for QI studies is the pre-post design, in which observations are made before and after each intervention that was implemented over a specified period. More sophisticated designs for QI studies enable a study team to draw stronger inferences about the system that is being changed and the individual effects of the interventions that are implemented...
October 14, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29045056/role-modelling-moving-from-implicit-to-explicit
#16
Anne Marie Pinard, Isabelle Savard, Luc Côté
No abstract text is available yet for this article.
October 16, 2017: Clinical Teacher
https://www.readbyqxmd.com/read/29043324/privileged-hydration-sites-in-aromatic-side-chains-effect-on-conformational-equilibrium
#17
Belén Hernández, Fernando Pflüger, Manuel Dauchez, Mahmoud Ghomi
Water interaction with peptide chains is one of the key structure stabilizing factors in an aqueous environment. Because of its strong polar character, water can bind to both anionic and cationic sites via electrostatic interactions. It can also act as a hydrogen-bond donor or acceptor according to its interactions with different polar groups in the backbone and side chains of peptides and proteins. Based on density functional theory calculations, the present report aims at illustrating the most energetically favorable interaction sites of aromatic side chains of phenylalanine, tyrosine, tryptophan, and histidine (neutral and protonated species) with surrounding water molecules...
October 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29040976/diagnosing-psychopathy-through-emotional-regulation-tasks-heart-rate-variability-versus-implicit-association-test
#18
Gerardo Flórez, Xosé A Vila, María J Lado, Pedro Cuesta, Ventura Ferrer, Luis S García, María R Crespo, Manuel Pérez
BACKGROUND: Nowadays, the assessment of psychopathy relies on semistructured interviews plus file reviews. In order to improve the predictive validity of psychopathy at the individual level, tools that are not based on the rating of signs and symptoms are in great need. SAMPLING AND METHODS: The present study was conducted in a representative sample of 204 Spanish sentenced inmates. These inmates have served at least 6 months of their sentence at the Pereiro de Aguiar (Ourense, Spain) penitentiary...
October 18, 2017: Psychopathology
https://www.readbyqxmd.com/read/29040750/cool-callous-and-in-control-superior-inhibitory-control-in-frequent-players-of-video-games-with-violent-content
#19
Laura Stockdale, Robert G Morrison, Robert Palumbo, James Garbarino, Rebecca L Silton
Research on the effects of media violence exposure has shown robust associations among violent media exposure, increased aggressive behavior, and decreased empathy. Preliminary research indicates that frequent players of violent video games may have differences in emotional and cognitive processes compared to infrequent or non-players, yet research examining the amount and content of game play and the relation of these factors with affective and cognitive outcomes is limited. The present study measured neural correlates of response inhibition in the context of implicit attention to emotion, and how these factors are related to empathic responding in frequent and infrequent players of video games with graphically violent content...
October 4, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/29040494/beyond-reward-prediction-errors-human-striatum-updates-rule-values-during-learning
#20
Ian Ballard, Eric M Miller, Steven T Piantadosi, Noah D Goodman, Samuel M McClure
Humans naturally group the world into coherent categories defined by membership rules. Rules can be learned implicitly by building stimulus-response associations using reinforcement learning or by using explicit reasoning. We tested if the striatum, in which activation reliably scales with reward prediction error, would track prediction errors in a task that required explicit rule generation. Using functional magnetic resonance imaging during a categorization task, we show that striatal responses to feedback scale with a "surprise" signal derived from a Bayesian rule-learning model and are inconsistent with RL prediction error...
October 13, 2017: Cerebral Cortex
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