keyword
https://read.qxmd.com/read/38512944/implementation-of-evidence-based-clinical-practice-and-its-associated-factors-among-health-care-workers-at-public-hospitals-in-sidama-regional-state-southern-ethiopia
#21
JOURNAL ARTICLE
Tomas Yeheyis, Dawit Hoyiso, Yacob Abraham Borie, Negash Tagesse
BACKGROUND: Health disparities, inconsistent outcomes, and underwhelming health services continue to be problems for all nurses and doctors. Studies from a variety of nations have found that doctors and nurses have little familiarity with evidence-based practice. There is a knowledge vacuum about the degree of evidence-based nursing practice and its contributing factors in Ethiopia as well as the current study region. OBJECTIVE: The study's objective was to evaluate how healthcare professionals working in government hospitals in the Sidama regional state of 2022 are implementing evidence-based clinical practice and to identify associated factors...
2024: PloS One
https://read.qxmd.com/read/38512891/stellera-chamaejasme-l-extract-inhibits-adipocyte-differentiation-through-activation-of-the-extracellular-signal-regulated-kinase-pathway
#22
JOURNAL ARTICLE
Jaegoo Yeon, Eunbin Kim, Badamtsetseg Bazarragchaa, Soo-Yong Kim, Jin Young Huh, Hyuntae Park, Sung-Suk Suh, Jong Bae Seo
Stellera chamaejasme L. (SCL) is a perennial herb with demonstrated bioactivities against inflammation and metabolic dysfunction. Adipocyte differentiation is a critical regulator of metabolic homeostasis and a promising target for the treatment of metabolic diseases, so we examined the effects of SCL on adipogenesis. A methanol extract of SCL dose-dependently suppressed intracellular lipid accumulation in adipocyte precursors cultured under differentiation induction conditions and reduced expression of the adipogenic transcription factors PPARγ and C/EBPα as well as the downstream lipogenic genes fatty acid binding protein 4, adiponectin, fatty acid synthase, and stearoyl-CoA desaturase...
2024: PloS One
https://read.qxmd.com/read/38510961/the-cutaneous-beta-human-papillomavirus-type-8-e6-protein-induces-ccl2-through-the-cebp%C3%AE-mir-203-p63-pathway-to-support-an-inflammatory-microenvironment-in-epidermodysplasia-verruciformis-skin-lesions
#23
JOURNAL ARTICLE
Luca Vella, Anna Sternjakob, Stefan Lohse, Alina Fingerle, Tanya Sperling, Claudia Wickenhauser, Michael Stöckle, Thomas Vogt, Klaus Roemer, Monika Ołdak, Sigrun Smola
Human papillomavirus type 8 (HPV8), a cutaneous genus beta HPV type, has co-carcinogenic potential at sun-exposed sites in patients suffering from the inherited skin disease epidermodysplasia verruciformis (EV). We had previously shown that Langerhans cells responsible for epithelial immunosurveillance were strongly reduced at infected sites and that the HPV8 E7 protein interferes with the CCAAT/enhancer-binding protein (C/EBP)β to suppress the Langerhans cell chemokine CCL20. At the same time, however, we observed that EV lesions are heavily infiltrated with inflammatory immune cells, which is similar to the situation in HPV8 E6 transgenic mice...
2024: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/38510207/stimulated-human-umbilical-cord-mesenchymal-stem-cells-enhance-the-osteogenesis-and-cranial-bone-regeneration-through-il-32-mediated-p38-signaling-pathway
#24
JOURNAL ARTICLE
Xiaru Zhang, Ying Zheng, Gang Wang, Yuanlin Liu, Yang Wang, Xueyi Jiang, Yueqing Liang, Xinfeng Zhao, Ping Li, Yi Zhang
OBJECTIVE: Our previous study found that it could significantly increase the expression of IL32 after stimulating the human umbilical cord mesenchymal stem cells (S-HuMSCs). However, its role on the osteogenesis and cranial bone regeneration is still largely unknown. Here, we investigated the possible mechanism of this effect. Material and Methods . A series of experiments, including single-cell sequencing, flow cytometry, quantitative real-time polymerase chain reaction, and western blotting, were carried out to evaluate the characteristic and adipogenic-osteogenic differentiation potential of IL-32 overexpression HuMSCs (IL-32high HuMSCs) through mediating the P38 signaling pathway...
2024: Stem Cells International
https://read.qxmd.com/read/38509237/prmt6-represses-the-pro-adipogenic-ppar-gamma-c-ebp-alpha-transcription-factor-loop
#25
JOURNAL ARTICLE
Mirjam Gerstner, Vivien Heller, Johannes Fechner, Benedikt Hermann, Lei Wang, Joern Lausen
The feed-forward loop between the transcription factors Ppar-gamma and C/ebp-alpha is critical for lineage commitment during adipocytic differentiation. Ppar-gamma interacts with epigenetic cofactors to activate C/ebp-alpha and the downstream adipocytic gene expression program. Therefore, knowledge of the epigenetic cofactors associated with Ppar-gamma, is central to understanding adipocyte differentiation in normal differentiation and disease. We found that Prmt6 is present with Ppar-gamma on the Ppar-gamma and C/ebp-alpha promoter...
March 20, 2024: Scientific Reports
https://read.qxmd.com/read/38508963/a-narrative-review-of-the-literature-relevant-to-obstetric-anesthesiologists-the-2023-gerard-w-ostheimer-lecture
#26
REVIEW
P Sultan
UNLABELLED: This narrative review of the 2023 Gerard W. Ostheimer lecture presented at the Society for Obstetric Anesthesia and Perinatology 2023 annual meeting summarizes 2022 literature relevant to obstetric anesthesiologists. ANTENATAL STUDIES: Neonatal morbidity is reduced with antenatal maternal buprenorphine compared with methadone for treatment of opioid use disorder. Antenatal pregnancy allergy testing is safe and feasible. ANALGESIA AND ANESTHESIA STUDIES: Intrathecal (IT) 3% chloroprocaine for cervical cerclage results in faster sensory block resolution and discharge readiness compared with bupivacaine...
January 3, 2024: International Journal of Obstetric Anesthesia
https://read.qxmd.com/read/38504441/trends-in-publication-impact-of-evidence-based-healthcare-terminology-2013-2022
#27
REVIEW
Annette M Bourgault, Jean W Davis, Jacqueline LaManna, Norma E Conner, Dawn Turnage
AIMS: This article explored the publication impact of evidence-based healthcare terminology to determine usage and discuss options for low usage terms. BACKGROUND: A plethora of terms describe the scholarship of evidence-based healthcare. Several terms are synonyms, creating redundancy and confusion. The abundance and overlap of terms may impede the discovery of evidence. DESIGN: This discursive article explored and discussed publication impact of evidence-based healthcare terms...
March 19, 2024: Journal of Advanced Nursing
https://read.qxmd.com/read/38503633/-implementation-of-a-novel-form-of-care-for-the-early-detection-and-prevention-of-emotional-and-behavioral-problems-in-children-in-the-pediatric-setting-qualitative-interviews-with-pediatricians-practice-staff-and-parents
#28
JOURNAL ARTICLE
Helene Hense, Sophia Ernst, Anja Zscheppang, Jochen Schmitt, Veit Roessner, Max Weniger, Katja Beesdo-Baum, Susanne Knappe
AIM OF THE STUDY: Evaluation of the implementation of a standardized screening using the Strengths and Difficulties Questionnaire (SDQ) as part of the routine pediatric health check-ups in the Dresden area (Germany) in order to detect emotional and behavioral problems (EBPs) in children early and allocate them to indicated preventive programs and/or to further counselling and treatment services. METHODS: 1.) Semi-structured interviews were performed with participating pediatricians (n=4), practice staff (n=4) and custodians of screened children (n=17) and subjected to content analysis regarding feasibility, advantages and disadvantages of the screening and the targeted allocation, as well as barriers and facilitators of using the screening and the preventive programs and further services...
March 18, 2024: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://read.qxmd.com/read/38498043/characteristics-of-occupational-therapy-interventions-to-promote-healthy-aging-protocol-for-a-scoping-review
#29
JOURNAL ARTICLE
Katrina Bannigan, Nicole Jade Larkan, Emmanuelle Renee Rogelia Meurgue, Jason Chun Hin Sze
BACKGROUND: Healthy aging is a pressing public health priority. Focusing on what people do every day may be a meaningful approach to lifestyle change, suggesting a need for occupation therapy interventions to promote healthy aging. A preliminary database search was conducted, and no current or underway systematic or scoping reviews on the topic were identified. Developing an overview of studies of occupational therapy interventions to promote healthy aging is a necessary first step to understanding the existing knowledge and increasing the impact of future interventions...
March 18, 2024: JMIR Research Protocols
https://read.qxmd.com/read/38490699/management-of-post-blood-patch-severe-rebound-intracranial-hypertension-by-the-usage-of-an-external-ventricular-drain
#30
JOURNAL ARTICLE
Leonardo Maresca, Maria Fragale, Giacomo Petrella, Davide Boeris
Spontaneous intracranial hypotension (SIH) is a condition characterised by postural headaches due to low cerebrospinal fluid (CSF) pressure, often stemming from CSF leakage. Diagnosis poses a significant challenge, and the therapeutic approach encompasses both conservative measures and operative interventions, such as the epidural blood patch (EBP). However, EBP carries the potential risk of inducing rebound intracranial hypertension (RIH), subsequently leading to high-pressure headaches. We present a case wherein RIH following EBP was effectively managed through the implementation of an external ventricular drain (EVD) aimed at reducing CSF pressure...
March 15, 2024: BMJ Case Reports
https://read.qxmd.com/read/38489482/-capacity-building-skills-in-the-implementation-of-evidence-based-practice-for-community-health-nurses-an-exploratory-descriptive-cohort-study
#31
JOURNAL ARTICLE
Susan Walsh, Catherine Ryan, Linda McCreary, Oscar Noel Ocho, Wiphawadee Potisopha, Rohan D Jeremiah
Background : While nurses are strategically placed to support the achievement of universal health, their practice may not always be informed by evidence, especially in a context where research evidence is not commonly used to inform practice. Objective/Aim/Hypothesis : Improve management of clients with CNCDs in Caribbean community through evidence-based practice (EBP) capacity building workshops. Design/Methods : A descriptive, quantitative design was used for this study. Participants included Community Based Nurses who attended an initial and recall workshop on EBP in a Caribbean island...
March 15, 2024: Contemporary Nurse
https://read.qxmd.com/read/38489237/describing-nurses-communication-about-evidence-based-practice-change-a-social-network-analysis-of-hospital-nurses
#32
JOURNAL ARTICLE
Élise N Arsenault Knudsen, Marlon P Mundt, Linsey M Steege
BACKGROUND: Nurses play a critical role in providing evidence-based, high-quality care to optimize patient outcomes. Models from implementation science suggest social networks may influence the adoption of evidence-based practices (EBPs). However, few studies have examined this relationship among hospital nurses. Social network analysis (SNA) mathematically evaluates patterns of communication, a critical step in implementation. Exploring hospital nurses' communication networks may provide insight into influences on the adoption of EBPs...
March 15, 2024: Worldviews on Evidence-based Nursing
https://read.qxmd.com/read/38489000/diagnostic-accuracy-of-endotoxin-and-endotoxin-binding-protein-in-late-onset-neonatal-sepsis
#33
JOURNAL ARTICLE
Divya Katta, Kopula Satyamoorthy Sridharan, UmaMaheswari Balakrishnan, Prakash Amboiram, Gopi Dhivya, Kennedy Kumar Palraj
OBJECTIVES: To evaluate the diagnostic utility of endotoxin and endotoxin binding protein (EBP) for the diagnosis of late-onset neonatal sepsis (LOS) and compare it with the diagnostic utility of C-reactive protein (CRP). METHODS: This diagnostic study of neonates, both term and preterm, with clinical suspicion of LOS was conducted in a tertiary care institute in India between January 2021 and March 2023. Blood samples were collected for evaluating endotoxin and EBP along with culture...
March 15, 2024: Indian Journal of Pediatrics
https://read.qxmd.com/read/38487817/psychotherapies-at-a-glance-consensus-guideline-recommended-psychotherapies-for-adults-with-psychiatric-disorders
#34
JOURNAL ARTICLE
Paula Ravitz, Luis E Flores, Danielle Novick, Priya Watson, Holly A Swartz
Clinical decision making by psychiatrists and informed consent by patients require knowledge of evidence-based psychotherapies (EBPs) and their indications. However, many mental health professionals are not versed in the empirical literature on EBPs or the consensus guideline recommendations derived from this literature. The authors compared rigorous national consensus guidelines for EBP treatment of DSM -defined adult psychiatric disorders-derived from well-conducted randomized controlled trials and meta-analyses and from expert opinions from the United States, United Kingdom, and Canada-to create the Psychotherapies-at-a-Glance tool...
March 15, 2024: American Journal of Psychotherapy
https://read.qxmd.com/read/38482768/palliative-care-communication-with-stroke-patients-a-best-practice-implementation-project
#35
JOURNAL ARTICLE
Ashley Brook Schaefer, Candon Garbo, Michelle Palokas
INTRODUCTION: Stroke patients frequently experience debilitating deficits, and some receive a terminal diagnosis. Palliative care services are introduced to prioritize care, with the goal of improving quality of life. However, palliative care communication (PCC) is often delayed or used inefficiently with stroke patients. OBJECTIVES: This project aimed to promote PCC evidence-based practices (EBPs) with stroke patients. METHODS: This project used the JBI Evidence Implementation Framework to improve compliance with PCC EBPs with stroke patients in a medical center in Mississippi, USA...
March 15, 2024: JBI evidence implementation
https://read.qxmd.com/read/38482331/augmenting-the-spirit-of-research-among-nursing-personnel-a-narrative-review
#36
REVIEW
Manisha Rani, Lily Podder, Geeta Bhardwaj
BACKGROUND: In health-related technology, the professionalism paradigm has shifted from a traditional-based approach to evidence-based nursing practice (EBP). For nurses, EBP as a systematic approach to problem solving is well supported and is based on translating the best current research findings into a decision made on patient care or nursing intervention. OBJECTIVE: To review the strategies to develop the research capacity among nurses. DESIGN: A keyword search was used to locate relevant articles...
January 2024: Journal of Family Medicine and Primary Care
https://read.qxmd.com/read/38481206/plasma-adiponectin-leptin-ratio-associates-with-subcutaneous-abdominal-and-omental-adipose-tissue-characteristics-in-women
#37
JOURNAL ARTICLE
Eve-Julie Tremblay, André Tchernof, Mélissa Pelletier, Denis R Joanisse, Pascale Mauriège
BACKGROUND: A better understanding of adipose tissue (AT) dysfunction, which includes morphological and functional changes such as adipocyte hypertrophy as well as impaired adipogenesis, lipid storage/mobilization, endocrine and inflammatory responses, is needed in the context of obesity. One dimension of AT dysfunction, secretory adiposopathy, often assessed as a low plasma adiponectin (A)/leptin (L) ratio, is commonly observed in obesity. The aim of this study was to examine markers of AT development and metabolism in 67 women of varying age and adiposity (age: 40-62 years; body mass index, BMI: 17-41 kg/m2 ) according to levels of adiponectinemia, leptinemia or the plasma A/L ratio...
March 14, 2024: BMC Endocrine Disorders
https://read.qxmd.com/read/38481184/effect-of-parenting-style-on-the-emotional-and-behavioral-problems-among-chinese-adolescents-the-mediating-effect-of-resilience
#38
JOURNAL ARTICLE
Jiana Wang, Xinyuan Huang, Zhe Li, Kun Chen, Zhiyu Jin, Jing He, Bingsong Han, Lin Feng, Nana Meng, Cong Yang, Zhuang Liu
BACKGROUND: Although previous studies have found that parenting style significantly predicts emotional and behavioral problems (EBPs) among Chinese adolescents, the mechanism between different parenting styles and EBPs requires in-depth investigation. In our study, we aimed to investigate the mediating effect of resilience, a positive psychological characteristic, between parenting style and EBPs among Chinese adolescents. METHODS: In this cross-sectional study, we used a multistage stratified cluster random sampling method to collect data in Shenyang, Liaoning Province from November to December 2019...
March 13, 2024: BMC Public Health
https://read.qxmd.com/read/38478826/lessons-learned-after-integrating-the-five-steps-of-evidence-based-practice-into-a-doctor-of-physical-therapy-curriculum
#39
JOURNAL ARTICLE
Angela Lis, Lauren Snowdon, Kyle Downey
BACKGROUND AND PURPOSE: Teaching evidence-based practice (EBP) has become a standard curricular goal for Doctor of Physical Therapy (DPT) education programs. In 2014, the American Physical Therapy Association published a consensus document to provide guidance on curricular objectives for teaching EBP in entry-level DPT programs. The document reinforced the need to promote skills related to the efficient and critical consumption of published evidence. The purpose of this case report is to describe the collaborative process of integrating the EBP guidelines in one university's DPT curriculum...
June 1, 2023: Journal, Physical Therapy Education
https://read.qxmd.com/read/38476419/recurrent-post-operative-extradural-and-subdural-collections-due-to-intracranial-hypotension-following-a-lumbar-subarachnoid-drain
#40
Abhijit Goyal-Honavar, Jeena Joseph, Gandham Edmond Jonathan, Krishna Prabhu
Intracranial hypotension (IH) represents a syndrome secondary to low cerebrospinal fluid pressure. This case of IH following a lumbar drain inserted before the excision of a left intraconal lesion, leading to recurrent post-operative unilateral subdural and extradural collections, was treated successfully with the evacuation of the collection and simultaneous epidural blood patch (EBP) injection. Our report provides an important perspective on the management of IH with recurrent intracranial collections and reiterates that IH should be considered when dealing with recurrent unilateral intracranial collections in the post-operative period...
2024: Journal of Neurosciences in Rural Practice
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