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https://www.readbyqxmd.com/read/29916532/resveratrol-induced-reactive-oxygen-species-and-endoplasmic-reticulum-stress%C3%A2-mediated-apoptosis-and-cell-cycle-arrest-in-the-a375sm-malignant-melanoma-cell-line
#1
Jae-Rim Heo, Soo-Min Kim, Kyung-A Hwang, Ji-Houn Kang, Kyung-Chul Choi
Resveratrol, a dietary product present in grapes, vegetables and berries, regulates several signaling pathways that control cell division, cell growth, apoptosis and metastasis. Malignant melanoma proliferates more readily in comparison with any other types of skin cancer. In the present study, the anti‑cancer effect of resveratrol on melanoma cell proliferation was evaluated. Treating A375SM cells with resveratrol resulted in a decrease in cell growth. The alteration in the levels of cell cycle‑associated proteins was also examined by western blot analysis...
June 15, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29914359/liver-transcriptome-analysis-reveals-extensive-transcriptional-plasticity-during-acclimation-to-low-salinity-in-cynoglossus-semilaevis
#2
Yufeng Si, Haishen Wen, Yun Li, Feng He, Jifang Li, Siping Li, Huiwen He
BACKGROUND: Salinity is an important abiotic stress that influences the physiological and metabolic activity, reproduction, growth and development of marine fish. It has been suggested that half-smooth tongue sole (Cynoglossus semilaevis), a euryhaline fish species, uses a large amount of energy to maintain osmotic pressure balance when exposed to fluctuations in salinity. To delineate the molecular response of C. semilaevis to different levels of salinity, we performed RNA-seq analysis of the liver to identify the genes and molecular and biological processes involved in responding to salinity changes...
June 18, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29910063/clinicopathological-and-prognostic-significance-of-c-ebp-homologous-protein-chop-in-advanced-gastric-cancer
#3
Xiangwen Zhang, Tingting Zhou, Wenbin Li, Taotao Zhang, Ninwei Che, Guo Zu
BACKGROUND: Few studies have reported the clinical and prognostic significance of C/EBP homologous protein (CHOP) in advanced gastric cancer (GC). Therefore, the present study investigated the expression of CHOP in advanced GC patients to determine its potential prognostic role. METHODS: The levels of CHOP in 95 patients with advanced GC and adjacent non-cancerous tissues were evaluated by qRT-PCR, western blot and immunohistochemistry. Furthermore, the association of CHOP expression with clinicopathological parameters and prognosis of advanced GC patients was analyzed...
June 12, 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29908848/the-obesogen-tributyltin-induces-abnormal-ovarian-adipogenesis-in-adult-female-rats
#4
Julia F P de Araújo, Priscila L Podratz, Gabriela C Sena, Eduardo Merlo, Leandro C Freitas-Lima, Júlia Gringorini Mori Ayub, Amanda Fidalgo Zogaib Pereira, Ana Paula Santos-Silva, Leandro Miranda-Alves, Ian V Silva, Jones B Graceli
Tributyltin chloride (TBT) is an obesogen associated with various metabolic and reproductive dysfunctions after in utero exposure. However, few studies have evaluated TBT's obesogenic effect on adult ovaries. In this study, we assessed whether TBT's obesogenic effects resulted in adult ovarian adipogenesis and other reproductive abnormalities. TBT was administered to adult female Wistar rats, and their reproductive tract morphophysiology was assessed. We further assessed the ovarian mRNA/protein expression of genes that regulate adipogenesis...
June 14, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29908494/protective-effect-of-exogenous-hydrogen-sulfide-on-pulmonary-artery-endothelial-cells-by-suppressing-endoplasmic-reticulum-stress-in-a-rat-model-of-chronic-obstructive-pulmonary-disease
#5
Hai-Bo Ding, Kai-Xiong Liu, Jie-Feng Huang, Da-Wen Wu, Jun-Ying Chen, Qing-Shi Chen
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a multicomponent disorder characterized by inflammation, representing a significant leading cause of chronic morbidity and mortality. Reports have implicated hydrogen sulfide (H2 S) in both the pathology and treatment of COPD. The present study aimed to explore the effects involved with exogenous H2 S on endoplasmic reticulum stress (ERS) and pulmonary artery endothelial cells (PAECs) in a rat model of COPD. METHODS: Rat models of COPD were successfully established by means of passive smoke exposure and intratracheal injection with lipopolysaccharide (LPS)...
June 13, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29908180/knocking-down-stard3-decreases-adipogenesis-with-decreased-mitochondrial-ros-in-3t3-l1-cells
#6
Xiaoqian Zhou, Huanqing Gao, Yinfeng Guo, Yaxi Chen, Xiong Z Ruan
Start domain-containing protein 3 (Stard3) plays roles in intracellular cholesterol distribution, however, the role of Stard3 in the adipogenesis of 3T3-L1 preadipocytes remains unclear. We demonstrated that Stard3 expression was significantly increased during the adipogenesis of 3T3-L1 preadipocytes, accompanied by an increase of mitochondrial Reactive oxygen species (ROS). Stard3 knocking-down inhibited 3T3-L1 preadipocyte adipogenesis with decreased mitochondrial ROS levels, while ROS inducer rescued the stard3 silencing 3T3 cells with increased ROS...
June 13, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29901626/curcumin-induces-endoplasmic-reticulum-stress-associated-apoptosis-in-human-papillary-thyroid-carcinoma-bcpap-cells-via-disruption-of-intracellular-calcium-homeostasis
#7
Li Zhang, Xian Cheng, Shichen Xu, Jiandong Bao, Huixin Yu
BACKGROUND: Thyroid cancer is the most common endocrine tumor. Our previous studies have demonstrated that curcumin can induce apoptosis in human papillary thyroid carcinoma BCPAP cells. However, the underlined mechanism has not been clearly elucidated. Endoplasmic reticulum (ER) is a major organelle for synthesis, maturation, and folding proteins as well as a large store for Ca. Overcoming chronically activated ER stress by triggering pro-apoptotic pathways of the unfolded protein response (UPR) is a novel strategy for cancer therapeutics...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29901175/increased-expression-of-chop-and-lc3b-in-newborn-rats-with-bronchopulmonary-dysplasia
#8
Mengyun Li, Bingting Pan, Yongyan Shi, Jianhua Fu, Xindong Xue
Bronchopulmonary dysplasia (BPD) seriously affects the health and prognosis of children, but the efficacy of treatments is poor. The present study aimed to examine the effects of C/EBP homologous protein (CHOP), activating transcription factor 4 (ATF4) and microtubule‑associated protein light chain 3β (LC3B), and the interaction between CHOP and LC3B, in newborn rats with BPD. At 1, 7, 14 and 21 days, the rats in the model [fraction of inspired oxygen (FiO2)=80‑85%] and control groups (FiO2=21%) were randomly sacrificed, and lung samples were collected...
June 8, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29901077/apelin%C3%A2-13-attenuates-er-stress%C3%A2-associated-apoptosis-induced-by-mpp-in-sh%C3%A2-sy5y-cells
#9
Yunlu Jiang, Haiqing Liu, Bingyuan Ji, Zhengwen Wang, Chunmei Wang, Chunqing Yang, Yanyou Pan, Jing Chen, Baohua Cheng, Bo Bai
Apelin‑13, a neuropeptide that acts as a ligand for a putative receptor related to the angiotensin II type receptor, elicits neuroprotective effects in numerous neurological conditions, such as Huntington's disease and cerebral ischemia. Parkinson's disease (PD), one of the most prevalent neurodegenerative diseases, is caused by damage to neurons in the brain; however, the underlying mechanism remains unclear. The present study explored the effects of apelin‑13 on SH‑SY5Y human neuroblastoma cells treated with 1‑methyl‑4‑phenylpyridine (MPP+)...
June 5, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29899319/rna-seq-analysis-reveals-a-positive-role-of-htr2a-in-adipogenesis-in-yan-yellow-cattle
#10
Jinyan Yun, Haiguo Jin, Yang Cao, Lichun Zhang, Yumin Zhao, Xin Jin, Yongsheng Yu
In this study, we performed high throughput RNA sequencing at the primary bovine preadipocyte (Day-0), mid-differentiation (Day-4), and differentiated adipocyte (Day-9) stages in order to characterize the transcriptional events regulating differentiation and function. The preadipocytes were isolated from subcutaneous fetal bovine adipose tissues and were differentiated into mature adipocytes. The adipogenic characteristics of the adipocytes were detected during various stages of adipogenesis (Day-0, Day-4, and Day-9)...
June 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29899261/-c-ebp%C3%AE-promotes-stat3-expression-and-affects-cell-apoptosis-and-proliferation-in-porcine-ovarian-granulosa-cells
#11
Xiaolong Yuan, Xiaofeng Zhou, Yingting He, Yuyi Zhong, Ailing Zhang, Zhe Zhang, Hao Zhang, Jiaqi Li
Previous studies suggest that signal transducer and activator of transcription 3 (STAT3) and CCAAT/enhancer binding protein beta (C/EBPβ) play an essential role in ovarian granulosa cells (GCs) for mammalian follicular development. Several C/EBPβ putative binding sites were previously predicted on the STAT3 promoter in mammals. However, the molecular regulation of C/EBPβ on STAT3 and their effects on cell proliferation and apoptosis remain virtually unexplored in GCs. Using porcine GCs as a model, the 5′-deletion, luciferase report assay, mutation, chromatin immunoprecipitation, Annexin-V/PI staining and EdU assays were applied to investigate the molecular mechanism for C/EBPβ regulating the expression of STAT3 and their effects on the cell proliferation and apoptosis ability...
June 13, 2018: Genes
https://www.readbyqxmd.com/read/29898634/meta-analysis-of-the-effects-of-exercise-training-on-markers-of-metabolic-syndrome-in-solid-organ-transplant-recipients
#12
Caixia Li, Jianming Xu, Wei Qin, Yan Hu, Huijuan Lu
BACKGROUND: The markers of metabolic syndrome can prompt the development of metabolic syndrome and are associated with worse graft function among transplant recipients. Studies have shown that exercise might be effective in reducing incidence rate of metabolic syndrome components in nontransplant patients. However, there is no sufficient evidence to determine whether exercise training is safe or effective for markers of metabolic syndrome among solid organ transplant recipients. OBJECTIVE: To evaluate the safety and efficacy of exercise training programs for risk markers of metabolic syndrome and to further evaluate its long-term effects in solid organ transplant recipients...
January 1, 2018: Progress in Transplantation
https://www.readbyqxmd.com/read/29896471/agency-leaders-assessments-of-feasibility-and-desirability-of-implementation-of-evidence-based-practices-in-youth-serving-organizations-using-the-stages-of-implementation-completion
#13
Lawrence A Palinkas, Mark Campbell, Lisa Saldana
Background: This study examined influences on the decisions of administrators of youth-serving organizations to initiate and proceed with implementation of an evidence-based practice (EBP). Methods: Semi-structured interviews, developed using the Stages of Implementation Completion (SIC) as a framework, were conducted with 19 agency chief executive officers and program directors of 15 organizations serving children and adolescents. Results: Agency leaders' self-assessments of implementation feasibility and desirability prior to implementation (Pre-implementation) were influenced by intervention affordability, feasibility, requirements, validity, reliability, relevance, cost savings, positive outcomes, and adequacy of information; availability of funding, support from sources external to the agency, and adequacy of technical assistance; and staff availability and attitudes toward innovation in general and EBPs in particular, organizational capacity, fit between the EBP and agency mission and capacity, prior experience with implementation, experience with seeking evidence, and developing consensus...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29894643/ameliorative-effect-of-sevoflurane-on-endoplasmic-reticulum-stress-mediates-cardioprotection-against-ischemic-reperfusion-injury
#14
Ai-Jie Liu, Chun-Xia Pang, Guo-Qiang Liu, Shi-Duan Wang, Chun-Qin Chu, Lin-Zhang Li, Yan Dong, De-Zhang Zhu
We aimed to investigate whether the cardioprotection of sevoflurane against ischemia/reperfusion (IR) injury is via inhibiting endoplasmic reticulum stress (ERS). The rat in vivo model of myocardial IR injury was induced by ligation of the left anterior descending (LAD) coronary artery. Sevoflurane significantly ameliorated the reduced cardiac function, increased infarct size and elevated troponin I level and lactate dehydrogenase (LDH) activity in plasma induced by IR injury. Sevoflurane suppressed the I/R-induced myocardial apoptosis...
June 12, 2018: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29893004/response-to-commentary-on-cheng-broome-feng-and-hu-2017-leadership-behaviours-play-a-significant-role-in-implementing-evidence-based-practice-journal-of-clinical-nursing-2018-27-e1684-e1685
#15
Lei Cheng, Sheng Feng, Yan Hu, Marion E Broome
Thank you for the opportunity to respond to Hu and Gifford's comments(Hu & Gifford, 2018). We appreciated their acknowledgement of our findings about the factors influencing the successful implementation of evidence-based practice (EBP). The authors described leadership behaviors as having a significant role in implementing evidence-based practice. This article is protected by copyright. All rights reserved.
June 12, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29887504/tnf-%C3%AE-induction-of-il-6-in-alveolar-type-ii-epithelial-cells-contributions-of-jnk-c-jun-ap-1-element-c-ebp%C3%AE-c-ebp-binding-site-and-ikk-nf-%C3%AE%C2%BAb-p65-%C3%AE%C2%BAb-site
#16
Chunguang Yan, Chunmin Deng, Xiufang Liu, Yutong Chen, Jiawei Ye, Rentian Cai, Yanfei Shen, Huifang Tang
Although participation of IL-6 in lung inflammation has been widely elucidated, the transcriptional regulation of its generation in alveolar type II cells stimulated by TNF-α remain unclear. Here, we find that TNF-α significantly induces IL-6 production, and TNF-α induction of IL-6 is mainly regulated at transcriptional level. Upon stimulated by TNF-α, Activator Protein-1 (AP-1)-mediated transcriptional activity is apparently increased in alveolar type II epithelial cells, which might be derived from elevated phosphorylation of JNK and subsequent activation of c-Jun...
June 7, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29884649/impaired-dna-demethylation-of-c-ebp-sites-causes-premature-aging
#17
Andrea Schäfer, Bernadette Mekker, Medhavi Mallick, Viviana Vastolo, Emil Karaulanov, Dominik Sebastian, Carina von der Lippen, Bernd Epe, Damien J Downes, Carola Scholz, Christof Niehrs
Changes in DNA methylation are among the best-documented epigenetic alterations accompanying organismal aging. However, whether and how altered DNA methylation is causally involved in aging have remained elusive. GADD45α (growth arrest and DNA damage protein 45A) and ING1 (inhibitor of growth family member 1) are adapter proteins for site-specific demethylation by TET (ten-eleven translocation) methylcytosine dioxygenases. Here we show that Gadd45a/Ing1 double-knockout mice display segmental progeria and phenocopy impaired energy homeostasis and lipodystrophy characteristic of Cebp ( CCAAT/enhancer-binding protein ) mutants...
June 8, 2018: Genes & Development
https://www.readbyqxmd.com/read/29883195/treatment-effects-of-parent-child-focused-evidence-based-programs-on-problem-severity-and-functioning-among-children-and-adolescents-with-disruptive-behavior
#18
Sarah Vidal, Christian M Connell
This study examined the treatment effects of manualized parent-child focused evidence-based programs (EBPs), characterized by an emphasis on parental involvement and engagement, on functioning and problem severity among a statewide sample of children and adolescents referred to outpatient psychiatric clinic for serious and persistent disruptive behavior. Propensity score matching was employed to account for baseline differences between children and adolescents (Mage  = 8.4 years; 26% girls; 42% White, 10% Black, 42% Hispanic, 5% other) who received parent-child focused EBPs (treatment group; n = 220) and treatment-as-usual (comparison group; n = 2,543)...
June 8, 2018: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/29875371/lobohedleolide-suppresses-hepatitis-c-virus-replication-via-jnk-c-jun-c-ebp-mediated-down-regulation-of-cyclooxygenase-2-expression
#19
Chun-Kuang Lin, Chin-Kai Tseng, Chih-Chuang Liaw, Chiung-Yao Huang, Chih-Ku Wei, Jyh-Horng Sheu, Jin-Ching Lee
Hepatitis C virus (HCV) chronically infects 2-3% people of the global population, which leads to liver cirrhosis and hepatocellular carcinoma. Drug resistance remains a serious problem that limits the effectiveness of US Food and Drug Administration (FDA)-approved direct-acting antiviral (DAA) drugs against HCV proteins. The objective of our study was to discover new antivirals from natural products to supplement current therapeutics. We demonstrated that lobohedleolide, isolated from the Formosan soft coral Lobophytum crassum, significantly reduced HCV replication in replicon cells and JFH-1 infection system, with EC50 values of 10 ± 0...
June 6, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29871729/sbar-tool-implementation-to-advance-communication-teamwork-and-the-perception-of-patient-safety-culture
#20
Raymond L Bonds
Current evidence reveals that surgical patients are more prone to adverse events when compared to any other population in the acute care setting. In a military training hospital, handoff communication between surgical intensive care unit (SICU) nurses, physicians, and anesthesia providers (certified registered nurse anesthetists and anesthesiologists) about patients being prepared for surgery was identified as a problem by an initial inquiry of the staff. This article discusses an evidence-based project (EBP) that utilized a standardized multidisciplinary Situation, Background, Assessment, Recommendation (SBAR) tool to improve communication, teamwork, and the perception of a patient safety culture between the SICU nurses and physicians and the anesthesia providers in preparation for surgery...
May 1, 2018: Creative Nursing
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