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https://www.readbyqxmd.com/read/28726344/barriers-to-using-electronic-evidence-based-literature-in-nursing-practice-a-systematised-review
#1
REVIEW
Farahnaz Sadoughi, Tania Azadi, Tannaz Azadi
BACKGROUND: Nurses' use of electronic literature has remained limited. OBJECTIVES: The aim of this study was to identify barriers concerning application of electronic literature on evidence based practice in nursing. METHODS: Six bibliographic databases were searched using the following keywords: challenges, barriers, obstacles, evidence based practice, EBP, information seeking, online databases, electronic literature, bibliographic databases and nurs*...
July 20, 2017: Health Information and Libraries Journal
https://www.readbyqxmd.com/read/28726342/social-workers-perceptions-of-barriers-to-interpersonal-therapy-implementation-for-treating-postpartum-depression-in-a-primary-care-setting-in-israel
#2
Rena Bina, Adi Barak, Barbara Posmontier, Saralee Glasser, Tali Cinamon
Research on evidence-based practice (EBP) implementation in social work often neglects to include evaluation of application barriers. This qualitative study examined social workers' perspectives of provider- and organisational-related barriers to implementing a brief eight-session interpersonal therapy (IPT) intervention, a time-limited EBP that addresses reducing depressive symptoms and improving interpersonal functioning. Implementation took place in a primary care setting in Israel and was aimed at treating women who have postpartum depression (PPD) symptoms...
July 20, 2017: Health & Social Care in the Community
https://www.readbyqxmd.com/read/28720140/a-mixed-methods-protocol-for-developing-and-testing-implementation-strategies-for-evidence-based-obesity-prevention-in-childcare-a-cluster-randomized-hybrid-type-iii-trial
#3
Taren Swindle, Susan L Johnson, Leanne Whiteside-Mansell, Geoffrey M Curran
BACKGROUND: Despite the potential to reach at-risk children in childcare, there is a significant gap between current practices and evidence-based obesity prevention in this setting. There are few investigations of the impact of implementation strategies on the uptake of evidence-based practices (EBPs) for obesity prevention and nutrition promotion. This study protocol describes a three-phase approach to developing and testing implementation strategies to support uptake of EBPs for obesity prevention practices in childcare (i...
July 18, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28715289/survey-of-methods-used-to-determine-if-a-patient-has-a-deep-vein-thrombosis-an-exploratory-research-report
#4
John D Heick, James W Farris
BACKGROUND: The use of evidence-based practice (EBP) is encouraged in the physical therapy profession, but integrating evidence into practice can be difficult for clinicians because of lack of time and other constraints. OBJECTIVE: To survey physical therapy clinical instructors and determine the methods they use for screening for deep vein thrombosis (DVT), a type of venous thromboembolism (VTE) in the lower extremities. DESIGN: Exploratory survey...
July 17, 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/28714016/elastin%C3%A2-derived-peptides-are-involved-in-the-processes-of-human-temporomandibular-disorder-by-inducing-inflammatory-responses-in-synovial-cells
#5
Kazuhiko Kobayashi, Rei Jokaji, Mayuko Miyazawa-Hira, Shigeyuki Takatsuka, Akira Tanaka, Kazuhiro Ooi, Hiroyuki Nakamura, Shuichi Kawashiri
Temporomandibular joint dysfunction (TMD) is a collection of clinical symptoms that involve masticatory muscles and the temporomandibular joint (TMJ). Common symptoms include limited jaw motion and joint sound/pain, along with TMJ disc displacement. TMD is frequently associated with synovitis, a chronic inflammation of the synovium. Fibroblast‑like synovial cells have been identified to produce several inflammatory mediators and may have an important role in the progression of TMJ inflammation. Degradation of the extracellular matrix molecule elastin may lead to the release of bioactive peptides...
July 15, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28709892/liuwei-dihuang-soft-capsules-attenuates-endothelial-cell-apoptosis-to-prevent-atherosclerosis-through-gpr30-mediated-regulation-in-ovariectomized-apoe-deficient-mice
#6
Yi Jing, Danfeng Cai, Qi Chen, Qingping Xiong, Tianhui Hu, Yuan Yao, Chao Lin, Xin Sun, Ying Lu, Xueyun Kong, Xiang Wu, Yu Li, Huimin Bian
ETHNOPHARMACOLOGICAL RELEVANCE: Liuwei Dihuang (LWDH), a classical traditional Chinese medicine prescription, has been widely used to prevent and to treat various diseases with symptoms of 'Kidney-Yin' deficiency syndrome for over 1000 years in China. It is commonly used to treat functional decline associated with senile disease and menopausal syndrome, especially memory decline, insomnia, diabetes and osteoporosis. Modern experimental pharmacological studies indicated that the mechanism of LWDH treatment of menopausal syndrome may be associated with enhanced estrogenic effects...
July 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28706487/pekinenin-e-inhibits-the-growth-of-hepatocellular-carcinoma-by-promoting-endoplasmic-reticulum-stress-mediated-cell-death
#7
Lu Fan, Qingling Xiao, Yanyan Chen, Gang Chen, Jinao Duan, Weiwei Tao
Hepatocellular carcinoma (HCC) is a malignant primary liver cancer with poor prognosis. In the present study, we report that pekinenin E (PE), a casbane diterpenoid derived from the roots of Euphorbia pekinensis, has a strong antitumor activity against human HCC cells both in vitro and in vivo. PE suppressed the growth of human HCC cells Hep G2 and SMMC-7721. In addition, PE-mediated endoplasmic reticulum (ER) stress caused increasing expressions of C/EBP homologous protein (CHOP), leading to apoptosis in HCC cells both in vitro and in vivo...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28706332/role-of-elsholtzia-communis-in-counteracting-stress-by-modulating-expression-of-hspa14-c-ebp-homologous-protein-nuclear-factor-erythroid-derived-2-like-2-factor-caspase-3-and-brain-derived-neurotrophic-factor-in-rat-hippocampus
#8
Chandana Choudhury Barua, Pompy Patowary, Arundhati Purkayastha, Prakash Haloi, Manab Jyoti Bordoloi
OBJECTIVE: Elsholtzia communis (Collett and Hemsl.) Diels has been widely distributed and is reported for many therapeutic effects. The present study aims to investigate the antistress activity of the leaf extract and its possible molecular mechanism. MATERIALS AND METHODS: Hydroethanolic extract of leaves of E. communis (100 and 200 mg/kg, p.o.) were administered for 7 days to stress-induced male Wistar rats. The experimental animals were divided into five groups (n = 6)...
March 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28695172/women-experiences-of-using-external-breast-prosthesis-after-mastectomy
#9
Zohra Asif Jetha, Raisa B Gul, Sharifa Lalani
OBJECTIVE: The aim of this study was to identify the experiences of breast cancer patients using external breast prostheses (EBP) in the context of the Pakistani society. METHODS: A qualitative descriptive exploratory design was used in the study. In-depth individual interviews were conducted with 15 postmastectomy women using EBP. A semi-structured interview guide with open-ended questions was used for the interviews. The analysis of the data was organized into four categories according to the study questions including reasons for using EBP, feeling about EBP, challenges for using EBP, and coping with lost breast...
July 2017: Asia-Pacific Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28694294/bacteroides-fragilis-enterotoxin-induces-the-formation-of-autophagosomes-in-endothelial-cells-but-interferes-their-autophagosomal-fusion-with-lysosomes-for-complete-autophagic-flux-through-a-mitogen-activated-protein-kinase-ap-1-and-c-ebp-homologous-protein
#10
Su Hyuk Ko, Jong Ik Jeon, Hyun Soo Myung, Young-Jeon Kim, Jung Mogg Kim
Bacteroides fragilis enterotoxin (BFT), a virulence factor of enterotoxigenic B. fragilis (ETBF), plays an essential role in mucosal inflammation. Although autophagy contributes to the pathogenesis of diverse infectious diseases, little is known about autophagy in ETBF infection. This study was conducted to investigate the role of BFT in the autophagic process in endothelial cells (ECs). Stimulation of human umbilical vein ECs (HUVECs) with BFT increased LC3-II conversion from LC3-I and protein expression of p62, Atg5 and Atg12...
July 10, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28691851/initiation-dropout-and-outcome-from-evidence-based-psychotherapies-in-a-va-ptsd-outpatient-clinic
#11
Barbara L Niles, Craig P Polizzi, Emily Voelkel, Elizabeth S Weinstein, Katharine Smidt, Lisa M Fisher
Trauma-focused, evidence-based psychotherapies (TF-EBPs) for posttraumatic stress disorder (PTSD) have been widely promoted in the Veterans Health Administration to provide access to state-of-the-art treatments, but dropout rates may affect the impact of TF-EBPs. The current study summarizes findings from a program evaluation of 67 veterans assigned to trauma-focused treatment in a Veterans Affairs outpatient PTSD clinic. Outcomes of interest include attendance rates, dropout rates and patterns, treatment paths, changes in self-reported symptoms, and clinician ratings...
July 10, 2017: Psychological Services
https://www.readbyqxmd.com/read/28689806/cigarette-smoke-impaired-maturation-of-ovarian-follicles-and-normal-growth-of-uterus-inner-wall-of-female-wild-type-and-hypertensive-rats
#12
Hae-Miru Lee, Cho-Won Kim, Kyung-A Hwang, Jae-Hyuck Sung, Jin-Kyu Lee, Kyung-Chul Choi
Cigarette smoke (CS) is well known to be very harmful to human body functions such as fertility, reproduction, and development. CS is considered to more affect patients with hypertension (HT). To estimate the effect of CS associated with female rat's fertility, we examined the histopathological characteristics of the uterus and ovary which were obtained from the female rats exposed to smoke of the standard cigarette (3R4F) for 4 weeks (10h a week) according to the OECD guidelines. The female wild-type Wistar Kyoto (WK) rats (WTR) and spontaneously hypertensive WK rats (SHR) were used to compare the effect of CS on healthy and hypertensive rats...
July 6, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28688954/rifampicin-induced-injury-in-hepg2-cells-is-alleviated-by-tudca-via-increasing-bile-acid-transporters-expression-and-enhancing-the-nrf2-mediated-adaptive-response
#13
Weiping Zhang, Lihong Chen, Hui Feng, Wei Wang, Yi Cai, Fen Qi, Xiaofang Tao, Jun Liu, Yujun Shen, Xiaofei Ren, Xi Chen, Jianming Xu, Yuxian Shen
Bile acid transporters and the nuclear factor erythroid 2-related factor (Nrf-2)-mediated adaptive response play important roles in the development of drug-induced liver injury (DILI). However, little is known about the contribution of the adaptive response to rifampicin (RFP)-induced cell injury. In this study, we found RFP decreased the survival rate of HepG2 cells and increased the levels of lactate dehydrogenase (LDH), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (AKP), γ-glutamyl-transferase (γ-GT), total bilirubin (TBIL), direct bilirubin (DBIL), indirect bilirubin (IBIL), total bile acid (TBA) and adenosine triphosphate (ATP) in the cell culture supernatants in both a concentration- and a time-dependent manner...
July 6, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28686850/the-effect-of-metformin-treatment-on-endoplasmic-reticulum-er-stress-induced-by-status-epilepticus-se-via-the-perk-eif2%C3%AE-chop-pathway
#14
Jing Chen, Guo Zheng, Hu Guo, Zhong-Nan Shi, Jiao Jiang, Xiao-Yu Wang, Xiao Yang, Xian-Yu Liu
Status epilepticus (SE) is defined as continuous seizure activity lasting more than 5 minutes. It results in neuronal cell death, mediated by endoplasmic reticulum (ER) stress response. Previously, metformin demonstrated neuroprotective effects in primary cortical neurons. In this study, we analyzed the effect of metformin on ER stress via the pro-apoptotic protein kinase RNA-like endoplasmic reticulum kinase (PERK) - eukaryotic initiation factor 2α (eIF2α) - C/EBP homologous protein (CHOP) pathway. SE was induced in rats by pentylenetetrazole...
July 7, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28686516/standardized-cirsium-setidens-nakai-ethanolic-extract-suppresses-adipogenesis-and-regulates-lipid-metabolisms-in-3t3-l1-adipocytes-and-c57bl-6j-mice-fed-high-fat-diets
#15
Bong-Yeon Cho, Mi-Ryeong Park, Jin-Ha Lee, Moon-Jin Ra, Kyoung Chan Han, Il-Jun Kang, Ok-Hwan Lee
Cirsium setidens Nakai, a wild perennial herb, grows mainly in Gangwon province, Korea, and has been reported to contain bioactive ingredients with various medicinal activities, including the treatment of edema, bleeding, and hemoptysis. However, the potential antiobesity effects of C. setidens Nakai have not been fully investigated. This study evaluated the antiobesity effect of standardized C. setidens Nakai ethanolic extract (CNE) in 3T3-L1 adipocytes and in obese C57BL/6J mice fed a high-fat diet. CNE suppressed the expression of lipogenic genes and increased the expression of lipolytic genes...
July 7, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28683029/evaluating-the-implementation-of-an-interdisciplinary-evidence-based-practice-educational-program-in-a-large-academic-medical-center
#16
Barbara L Wilson, Melissa Banner, Mary Jean Austria, Andrew Wilson
The purpose of this study was to create a system-wide education program in a large academic medical center to increase exposure and understanding of the evidence-based practice (EBP) process with multidisciplinary healthcare professionals. We also hoped to increase their confidence in utilizing and implementing EBP at the bedside. Although our approach to educating professional staff on EBP provided initial benefits, holding the gains over a 1-year period proved to be difficult.
July 2017: Journal for Nurses in Professional Development
https://www.readbyqxmd.com/read/28682901/downregulation-of-smac-attenuates-h2o2-induced-apoptosis-via-endoplasmic-reticulum-stress-in-human-lens-epithelial-cells
#17
Kong De-Qian, Liu Yue, Li Li, Zheng Guangying
BACKGROUND: Second mitochondria-derived activator of caspases (Smac) is reported to promote apoptosis. Given the important role of apoptosis in cataract development, the aim of this study was to investigate whether Smac induces human lens epithelial cell (HLEC) apoptosis via endoplasmic reticulum stress (ERS). METHODS: Smac expression was examined by immunohistochemistry in anterior lens capsules from 157 patients with age-related cataracts and 5 normal controls...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28681446/sources-of-knowledge-and-barriers-of-implementing-evidence-based-practice-among-mental-health-nurses-in-saudi-arabia
#18
Shaher H Hamaideh
PURPOSES: The purposes of this study were to identify the sources of knowledge for nursing practices and to identify the barriers of using "evidence-based practice" (EBP). DESIGN AND METHODS: Descriptive cross-sectional design was used to collect data from 164 Saudi mental health nurses by completing the Development of Evidence-Based Practice Questionnaire. FINDINGS: The most frequently used sources of knowledge were relied on social interactions and the nurses' own experiences, while the least frequently used sources were external sources of knowledge and research evidences...
July 2017: Perspectives in Psychiatric Care
https://www.readbyqxmd.com/read/28678786/bidirectional-interplay-of-hsf1-degradation-and-upr-activation-promotes-tau-hyperphosphorylation
#19
Eunhee Kim, Kazuko Sakata, Francesca-Fang Liao
The unfolded protein response (UPR) in the endoplasmic reticulum (ER) and the cytoplasmic heat stress response are two major stress response systems necessary for maintaining proteostasis for cellular health. Failure of either of these systems, such as in sustained UPR activation or in insufficient heat shock response activation, can lead to the development of neurodegeneration. Alleviation of ER stress and enhancement of heat shock response through heat shock factor 1 (HSF1) activation have previously been considered as attractive potential therapeutic targets for Alzheimer's disease (AD)-a prevalent and devastating tauopathy...
July 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28673838/benzo-a-pyrene-induced-cell-cycle-arrest-and-apoptosis-in-human-choriocarcinoma-cancer-cells-through-reactive-oxygen-species-induced-endoplasmic-reticulum-stress-pathway
#20
Soo-Min Kim, Hae-Miru Lee, Kyung-A Hwang, Kyung-Chul Choi
Cigarette smoke (CS) contains over 60 well established carcinogens. In this study, we examined the effects of benzo(a)pyrene (B(a)P), a main CS component, on the viability and apoptosis of JEG-3 and BeWo human choriocarcinoma cancer cell lines. An MTT assay confirmed that B(a)P decreased the cell viability of JEG-3 and BeWo cells in a dose-dependent manner. Additionally, Western blot (WB) assay revealed that protein expression of cyclin D and cyclin E decreased, while protein expression of p21 and p27 was increased in response to B(a)P treatment for 48 h...
July 1, 2017: Food and Chemical Toxicology
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