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https://www.readbyqxmd.com/read/28210454/managing-patients-taking-edoxaban-in-dentistry
#1
REVIEW
Adrian Curto, Daniel Curto, Jorge Sanchez
BACKGROUND: Anticoagulation therapy is used in several conditions to prevent or treat thromboembolism. A new group of oral anticoagulants with clear advantages over classic dicoumarin oral anticoagulants (warfarin and acenocoumarol) has been developed in recent years. The Food and Drug Administration has approved edoxaban, dabigatran, rivaroxaban and apixaban. Their advantages include: predictable pharmacokinetics, drug interactions and limited food, rapid onset of action and short half-life...
February 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28210452/ewing-sarcoma-of-the-oral-cavity-a-review
#2
REVIEW
Maria Margaix-Muñoz, José Bagán, Rafael Poveda-Roda
OBJECTIVES: A review is made of the clinical, diagnostic, therapeutic and survival characteristics of Ewing sarcoma (ES) of the oral cavity. MATERIAL AND METHODS: A systematic literature search was carried out, with restrictions referred to time (1960-2014), language (English and Spanish) and type of study (case reports, letters, datasets, reviews). The following MeSH terms and boolean operators were used: Ewing AND Sarcoma AND [tongue, jaw, maxilla, cheek, condyle OR temporomandibular, floor AND mouth, gum OR gingiva, palate OR palatal, lip, uvula, head AND neck]...
February 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28207295/competent-geometric-semantic-genetic-programming-for-symbolic-regression-and-boolean-function-synthesis
#3
Tomasz P Pawlak, Krzysztof Krawiec
Program semantics is a promising recent research thread in Genetic Programming (GP). Over a dozen of semantic-aware search, selection, and initialization operators for GP have been proposed to date. Some of those operators are designed to exploit the geometric properties of semantic space, while some others focus on making offspring effective, i.e., semantically different from their parents. Only a small fraction of previous works aimed at addressing both these features simultaneously. In this paper, we propose a suite of competent operators that combine effectiveness with geometry for population initialization, mate selection, mutation and crossover...
February 16, 2017: Evolutionary Computation
https://www.readbyqxmd.com/read/28203004/-a-method-for-rapid-extracting-three-dimensional-root-model-of-vivo-tooth-from-cone-beam-computed-tomography-data-based-on-the-anatomical-characteristics-of-periodontal-ligament
#4
Y J Zhao, S W Wang, Y Liu, Y Wang
OBJECTIVE: To explore a new method for rapid extracting and rebuilding three-dimensional (3D) digital root model of vivo tooth from cone beam computed tomography (CBCT) data based on the anatomical characteristics of periodontal ligament, and to evaluate the extraction accuracy of the method. METHODS: In the study, 15 extracted teeth (11 with single root, 4 with double roots) were collected from oral clinic and 3D digital root models of each tooth were obtained by 3D dental scanner with a high accuracy 0...
February 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28190380/passive-prosthetic-hands-and-tools-a-literature-review
#5
Bartjan Maat, Gerwin Smit, Dick Plettenburg, Paul Breedveld
BACKGROUND: The group of passive prostheses consists of prosthetic hands and prosthetic tools. These can either be static or adjustable. Limited research and development on passive prostheses has been performed although many people use these prosthesis types. Although some publications describe passive prostheses, no recent review of the peer-reviewed literature on passive prostheses is available. OBJECTIVE: Review the peer-reviewed literature on passive prostheses for replacement of the hand...
February 1, 2017: Prosthetics and Orthotics International
https://www.readbyqxmd.com/read/28187161/modeling-hormonal-control-of-cambium-proliferation
#6
Vladyslav Oles, Alexander Panchenko, Andrei Smertenko
Rise of atmospheric CO2 is one of the main causes of global warming. Catastrophic climate change can be avoided by reducing emissions and increasing sequestration of CO2. Trees are known to sequester CO2 during photosynthesis, and then store it as wood biomass. Thus, breeding of trees with higher wood yield would mitigate global warming as well as augment production of renewable construction materials, energy, and industrial feedstock. Wood is made of cellulose-rich xylem cells produced through proliferation of a specialized stem cell niche called cambium...
2017: PloS One
https://www.readbyqxmd.com/read/28186191/the-combination-of-the-functionalities-of-feedback-circuits-is-determinant-for-the-attractors-number-and-size-in-pathway-like-boolean-networks
#7
Eugenio Azpeitia, Stalin Muñoz, Daniel González-Tokman, Mariana Esther Martínez-Sánchez, Nathan Weinstein, Aurélien Naldi, Elena R Álvarez-Buylla, David A Rosenblueth, Luis Mendoza
Molecular regulation was initially assumed to follow both a unidirectional and a hierarchical organization forming pathways. Regulatory processes, however, form highly interlinked networks with non-hierarchical and non-unidirectional structures that contain statistically overrepresented circuits or motifs. Here, we analyze the behavior of pathways containing non-unidirectional (i.e. bidirectional) and non-hierarchical interactions that create motifs. In comparison with unidirectional and hierarchical pathways, our pathways have a high diversity of behaviors, characterized by the size and number of attractors...
February 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28182683/a-mathematical-model-of-the-interaction-of-abscisic-acid-ethylene-and-methyl-jasmonate-on-stomatal-closure-in-plants
#8
Allen Lamarca Nazareno, Bryan Sapon Hernandez
Stomatal closure is affected by various stimuli such as light, atmospheric carbon dioxide concentration, humidity and phytohormones. Our research focuses on phytohormones, specifically: abscisic acid (ABA), ethylene (ET) and methyl jasmonate (MeJA) that are responsible for the regulation of several plant processes, especially in guard cell signalling. While several studies show that these three phytohormones cause stomatal closure in plants, only two studies are notable for establishing a mathematical model of guard cell signalling involving phytohormones...
2017: PloS One
https://www.readbyqxmd.com/read/28178334/a-novel-mutual-information-based-boolean-network-inference-method-from-time-series-gene-expression-data
#9
Shohag Barman, Yung-Keun Kwon
BACKGROUND: Inferring a gene regulatory network from time-series gene expression data in systems biology is a challenging problem. Many methods have been suggested, most of which have a scalability limitation due to the combinatorial cost of searching a regulatory set of genes. In addition, they have focused on the accurate inference of a network structure only. Therefore, there is a pressing need to develop a network inference method to search regulatory genes efficiently and to predict the network dynamics accurately...
2017: PloS One
https://www.readbyqxmd.com/read/28176866/ferroelectric-symmetry-protected-multibit-memory-cell
#10
Laurent Baudry, Igor Lukyanchuk, Valerii M Vinokur
The tunability of electrical polarization in ferroelectrics is instrumental to their applications in information-storage devices. The existing ferroelectric memory cells are based on the two-level storage capacity with the standard binary logics. However, the latter have reached its fundamental limitations. Here we propose ferroelectric multibit cells (FMBC) utilizing the ability of multiaxial ferroelectric materials to pin the polarization at a sequence of the multistable states. Employing the catastrophe theory principles we show that these states are symmetry-protected against the information loss and thus realize novel topologically-controlled access memory (TAM)...
February 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28176601/fasciotomy-closure-techniques
#11
Julio J Jauregui, Samantha J Yarmis, Justin Tsai, Kemjika O Onuoha, Emmanuel Illical, Carl B Paulino
We evaluated the risks and success rates of the three major techniques for compartment syndrome fasciotomy closure by reviewing all literature published to date. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we systematically evaluated the Medline (PubMed) database until July 2015, utilizing the Boolean search sting "compartment syndrome OR fasciotomy closure." Two authors independently assessed all studies published in the literature to ensure validity of extracted data...
January 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28160385/processing-binary-and-fuzzy-logic-by-chaotic-time-series-generated-by-a-hydrodynamic-photochemical-oscillator
#12
Pier Luigi Gentili, Maria Sole Giubila, B Mark Heron
This work demonstrates the computational power of a hydrodynamic photochemical oscillator based on a photochromic naphthopyran, generating aperiodic time series. The chaotic character of the time series is tested by calculating its largest Lyapunov exponent and the correlation dimension of its attractor after building its phase space through the Takens' theorem. Then, the chaotic dynamic is shown to be suitable to implement all the fundamental Boolean two-inputs-one-output logic gates. Finally, the strategy to implement Fuzzy logic systems (FLSs) based on the time series is described...
February 3, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28155725/moro-a-cytoscape-app-for-relationship-analysis-between-modularity-and-robustness-in-large-scale-biological-networks
#13
Cong-Doan Truong, Tien-Dzung Tran, Yung-Keun Kwon
BACKGROUND: Although there have been many studies revealing that dynamic robustness of a biological network is related to its modularity characteristics, no proper tool exists to investigate the relation between network dynamics and modularity. RESULTS: Accordingly, we developed a novel Cytoscape app called MORO, which can conveniently analyze the relationship between network modularity and robustness. We employed an existing algorithm to analyze the modularity of directed graphs and a Boolean network model for robustness calculation...
December 23, 2016: BMC Systems Biology
https://www.readbyqxmd.com/read/28155685/sig2grn-a-software-tool-linking-signaling-pathway-with-gene-regulatory-network-for-dynamic-simulation
#14
Fan Zhang, Runsheng Liu, Jie Zheng
BACKGROUND: Linking computational models of signaling pathways to predicted cellular responses such as gene expression regulation is a major challenge in computational systems biology. In this work, we present Sig2GRN, a Cytoscape plugin that is able to simulate time-course gene expression data given the user-defined external stimuli to the signaling pathways. METHODS: A generalized logical model is used in modeling the upstream signaling pathways. Then a Boolean model and a thermodynamics-based model are employed to predict the downstream changes in gene expression based on the simulated dynamics of transcription factors in signaling pathways...
December 23, 2016: BMC Systems Biology
https://www.readbyqxmd.com/read/28154506/efficient-strategy-to-identify-gene-gene-interactions-and-its-application-to-type-2-diabetes
#15
Donghe Li, Sungho Won
Over the past decade, the detection of gene-gene interactions has become more and more popular in the field of genome-wide association studies (GWASs). The goal of the GWAS is to identify genetic susceptibility to complex diseases by assaying and analyzing hundreds of thousands of single-nucleotide polymorphisms. However, such tests are computationally demanding and methodologically challenging. Recently, a simple but powerful method, named "BOolean Operation-based Screening and Testing" (BOOST), was proposed for genome-wide gene-gene interaction analyses...
December 2016: Genomics & Informatics
https://www.readbyqxmd.com/read/28154501/computational-methods-for-asynchronous-basins
#16
Ian H Dinwoodie
For a Boolean network we consider asynchronous updates and define the exclusive asynchronous basin of attraction for any steady state or cyclic attractor. An algorithm based on commutative algebra is presented to compute the exclusive basin. Finally its use for targeting desirable attractors by selective intervention on network nodes is illustrated with two examples, one cell signalling network and one sensor network measuring human mobility.
December 2016: Discrete and Continuous Dynamical Systems. Series B
https://www.readbyqxmd.com/read/28153828/clinical-benefit-of-1-year-certolizumab-pegol-czp-add-on-therapy-to-methotrexate-treatment-in-patients-with-early-rheumatoid-arthritis-was-observed-following-czp-discontinuation-2-year-results-of-the-c-opera-study-a-phase-iii-randomised-trial
#17
Tatsuya Atsumi, Yoshiya Tanaka, Kazuhiko Yamamoto, Tsutomu Takeuchi, Hisashi Yamanaka, Naoki Ishiguro, Katsumi Eguchi, Akira Watanabe, Hideki Origasa, Shinsuke Yasuda, Yuji Yamanishi, Yasuhiko Kita, Tsukasa Matsubara, Masahiro Iwamoto, Toshiharu Shoji, Osamu Togo, Toshiyuki Okada, Désirée van der Heijde, Nobuyuki Miyasaka, Takao Koike
OBJECTIVES: To investigate the clinical impact of 1-year certolizumab pegol (CZP) therapy added to the first year of 2-year methotrexate (MTX) therapy, compared with 2-year therapy with MTX alone. METHODS: MTX-naïve patients with early rheumatoid arthritis (RA) with poor prognostic factors were eligible to enter Certolizumab-Optimal Prevention of joint damage for Early RA (C-OPERA), a multicentre, randomised, controlled study, which consisted of a 52-week double-blind (DB) period and subsequent 52-week post treatment (PT) period...
February 2, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28152859/faster-ways-of-pursuing-quality-control-using-ehr-electronic-health-record
#18
Samip R Master, Glenn Morris Mills, Richard P Mansour
: 169 Background: In this era of electronic health records (EHR), quality monitoring can be a fast repetitive process. Having access to the relational database of the EHR permits rapid case identification and quality indicator determination. We hereby describe evaluation of hepatitis B testing prior to rituximab administration, a quality measure as per ASCO guidelines. METHODS: We connected SQL Query Manager with EPIC Clarity database. Using the object model for medication orders, location and department, we used SQL language to build a temporary dataset of all patients who have a completed order for a Rituximab infusion at a specific department location within the past 6 months...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28150999/adaptive-local-information-transfer-in-random-boolean-networks
#19
Taichi Haruna
Living systems such as gene regulatory networks and neuronal networks have been supposed to work close to dynamical criticality, where their information-processing ability is optimal at the whole-system level. We investigate how this global information-processing optimality is related to the local information transfer at each individual-unit level. In particular, we introduce an internal adjustment process of the local information transfer and examine whether the former can emerge from the latter. We propose an adaptive random Boolean network model in which each unit rewires its incoming arcs from other units to balance stability of its information processing based on the measurement of the local information transfer pattern...
February 2, 2017: Artificial Life
https://www.readbyqxmd.com/read/28148701/need-for-improvement-in-current-treatment-of-psoriatic-arthritis-study-of-an-outpatient-clinic-population
#20
Brigitte Michelsen, Andreas P Diamantopoulos, Hege Kilander Høiberg, Dag Magnar Soldal, Arthur Kavanaugh, Glenn Haugeberg
OBJECTIVE: To explore the burden of skin, joint, and entheses manifestations in a representative psoriatic arthritis (PsA) outpatient cohort in the biologic treatment era. METHODS: This was a cross-sectional study of 141 PsA outpatients fulfilling the ClASsification for Psoriatic ARthritis (CASPAR) criteria and examined between January 2013 and May 2014. Selected disease activity measures were explored including Disease Activity index for PSoriatic Arthritis (DAPSA), Composite Psoriatic Disease Activity Index (CPDAI), Psoriatic Arthritis Disease Activity Score (PASDAS), Disease Activity Score for 28 joints (DAS28), Simplified Disease Activity Index (SDAI), and Psoriasis Area Severity Index (PASI)...
February 1, 2017: Journal of Rheumatology
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