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Ricardo J O Ferreira, Cátia Duarte, Mwidimi Ndosi, Maarten de Wit, Laure Gossec, J A P da Silva
OBJECTIVES: In current management paradigms of Rheumatoid Arthritis (RA), patient global assessment (PGA) is crucial to decide whether a patient has attained remission (target) or needs reinforced therapy. We investigated whether the clinical and psychological determinants of PGA are appropriate to support this important role. METHODS: This was a cross-sectional, single centre study including consecutive ambulatory RA patients. Data collection comprised swollen (SJC28) and tender joint counts (TJC28), C-Reactive protein (CRP), PGA, pain, fatigue, function, anxiety, depression, happiness, personality traits, and comorbidities...
May 23, 2017: Arthritis Care & Research
Andrzej Mizera, Jun Pang, Qixia Yuan
Probabilistic Boolean networks (PBNs) is a well-established computational framework for modelling biological systems. The steady-state dynamics of PBNs is of crucial importance in the study of such systems. However, for large PBNs, which often arise in systems biology, obtaining the steady-state distribution poses a significant challenge. In this paper, we revive the two-state Markov chain approach to solve this problem. This paper contributes in three aspects. First, we identify a problem of generating biased results with the approach and we propose a few heuristics to avoid such a pitfall...
May 16, 2017: IEEE/ACM Transactions on Computational Biology and Bioinformatics
Magnus Find, Mika Göös, Matti Järvisalo, Petteri Kaski, Mikko Koivisto, Janne H Korhonen
Given a boolean n × n matrix A we consider arithmetic circuits for computing the transformation x ↦ Ax over different semirings. Namely, we study three circuit models: monotone OR-circuits, monotone SUM-circuits (addition of non-negative integers), and non-monotone XOR-circuits (addition modulo 2). Our focus is on separating OR-circuits from the two other models in terms of circuit complexity: We show how to obtain matrices that admit OR-circuits of size O(n), but require SUM-circuits of size Ω(n(3/2)/log(2)n)...
August 2016: Journal of Computer and System Sciences
S Lilienthal, M Klein, R Orbach, I Willner, F Remacle, R D Levine
The concentration of molecules can be changed by chemical reactions and thereby offer a continuous readout. Yet computer architecture is cast in textbooks in terms of binary valued, Boolean variables. To enable reactive chemical systems to compute we show how, using the Cox interpretation of probability theory, one can transcribe the equations of chemical kinetics as a sequence of coupled logic gates operating on continuous variables. It is discussed how the distinct chemical identity of a molecule allows us to create a common language for chemical kinetics and Boolean logic...
March 1, 2017: Chemical Science
Naseem Akhtar Qureshi, Gazzaffi Ibrahim Ali, Tamer Shaban Abushanab, Ahmed Tawfik El-Olemy, Meshari Saleh Alqaed, Ibrahim S El-Subai, Abdullah M N Al-Bedah
Cupping (Hijama in Arabic) is an ancient, holistic method for the treatment of a variety of diseases. Though the exact origin of cupping therapy is a matter of controversy, its use has been documented in early Egyptian and Chinese medical practices. Diverse human civilizations have contributed to the historical development and continuation of cupping therapy. This narrative review describes the history of cupping, historical definitions, cupping instruments and uses of cupping therapy. Electronic searches of relevant databases (PubMed, Google Scholar and OvidSP) were conducted using keywords and Boolean operators...
May 2017: Journal of Integrative Medicine
Jiancheng Li, Bizhen Cheng, Huizhen Ouyang, Tongtong Xiao, Jing Hu, Yingmu Cai
PURPOSE: Following the analytical phase, the current practice of many hospital laboratories involves the manual verification of all test results followed by the production of the report. However, manual verification is a time-consuming and tedious process. In this paper, we provide a detailed description of how to design autoverification rules for thyroid function test profiles and sex hormones. MaterialsandMethods: We used DM2 (Data manager 2) to construct the algorithm and build the database for autoverification of thyroid function test profiles and sex hormones, with reference to Boolean logic, Auto-10A and CLSI'88...
January 1, 2017: Annals of Clinical Biochemistry
Anastasia I Lavrova, Eugene B Postnikov, Andrey Yu Zyubin, Svetlana V Babak
We consider two approaches to modelling the cell metabolism of 6-mercaptopurine, one of the important chemotherapy drugs used for treating acute lymphocytic leukaemia: kinetic ordinary differential equations, and Boolean networks supplied with one controlling node, which takes continual values. We analyse their interplay with respect to taking into account ATP concentration as a key parameter of switching between different pathways. It is shown that the Boolean networks, which allow avoiding the complexity of general kinetic modelling, preserve the possibility of reproducing the principal switching mechanism...
April 2017: Royal Society Open Science
Lyn Tieu, Jacopo Romoli, Eva Poortman, Yoad Winter, Stephen Crain
Previous developmental studies of conjunction have focused on the syntax of phrasal and sentential coordination (Lust, 1977; de Villiers, Tager-Flusberg & Hakuta, 1977; Bloom, Lahey, Hood, Lifter & Fiess, 1980, among others). The present study examined the flexibility of children's interpretation of conjunction. Specifically, when two predicates that can apply simultaneously to a single individual are conjoined in the scope of a plural definite (The bears are big and white), conjunction receives a Boolean, intersective interpretation...
May 8, 2017: Journal of Child Language
Se-Woong Chun, Chai-Young Lim, Keewon Kim, Jinseub Hwang, Sun G Chung
BACKGROUND CONTEXT: Clinicians regard lumbar lordotic curvature (LLC) with respect to low back pain (LBP) in a contradictory fashion. The time-honored point of view is that LLC itself, or its increment causes LBP. On the other hand, recently, the biomechanical role of LLC has been emphasized and loss of lordosis is considered a possible cause of LBP. The relationship between LLC and LBP has immense clinical significance, since it serves as the basis of therapeutic exercises for treating and preventing LBP...
May 2, 2017: Spine Journal: Official Journal of the North American Spine Society
Barbara Fresch, Juanita Bocquel, Dawit Hiluf, Sven Rogge, Raphael D Levine, Francoise Remacle
To realize low power compact logic circuits one can explore parallel operation on single nanoscale devices. An added incentive is to use multivalued (as distinct from Boolean) logic. Here we theoretically demonstrate that the computation of all the possible outputs of a multivariate, multivalued logic function can be implemented in parallel by electrical addressing of a molecule made up of three interacting dopant atoms embedded in Si. The electronic states of the dopant molecule are addressed by pulsing a gate voltage...
May 4, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
Evgeny Katz, Maria Gamella, Marina Privman, Saira Bakshi, Artem Melman
Signal-controlled release of DNA from Fe3+-cross-linked alginate hydrogel electrochemically deposited on an electrode surface was studied. The multiple input signals were logically processed with the help of the enzyme biocatalyzed reactions. Boolean logic gates, OR, AND, INH, were realized with the biocatalytic reactions performed by the enzymes entrapped in the alginate film. Hydrogen peroxide produced by the enzymatic reactions resulted in the degradation of the alginate hydrogel and DNA release. The alginate degradation was facilitated by the formation of free radicals in the Fenton-type reaction catalyzed by iron cations cross-linking the alginate hydrogel...
May 3, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
Nirmal Singh
The research productivity on Zika virus (ZV) had been evaluated applying scientometrics. The different aspects of scientific literature on the subject under study accessible through 'Scopus' were explored. An advanced search was conducted in the database for 'Zika' and 'Virus' as main operators for analytical purposes. Search terms were connected using Boolean Operator 'AND' to retrieve relevant records. The search results were further filtered for journals articles. A total of 573 ZV associated records were retrieved including 6 duplicate items, after deleting which the relevant results remained 567...
September 2016: Virusdisease
Yuhu Wu, Jingxue Xu, Xi-Ming Sun, Wei Wang
Boolean multiplex (multilevel) networks (BMNs) are currently receiving considerable attention as theoretical arguments for modeling of biological systems and system level analysis. Studying control-related problems in BMNs may not only provide new views into the intrinsic control in complex biological systems, but also enable us to develop a method for manipulating biological systems using exogenous inputs. In this article, the observability of the Boolean multiplex control networks (BMCNs) are studied. First, the dynamical model and structure of BMCNs with control inputs and outputs are constructed...
April 28, 2017: Scientific Reports
Anne Grimbs, Abhinandan Shrestha, Ahmed S D Rezk, Sergio Grimbs, Inamullah Hakeem Said, Hartwig Schepker, Marc-Thorsten Hütt, Dirk C Albach, Klaudia Brix, Nikolai Kuhnert, Matthias S Ullrich
The exceptional diversity of the genus Rhododendron has a strong potential for identification, characterization, and production of bioactive lead compounds for health purposes. A particularly relevant field of application is the search for new antibiotics. Here, we present a comparative analysis of nearly 90 Rhododendron species targeted toward the search for such candidate substances. Through a combination of phytochemical profiles with antimicrobial susceptibility and cytotoxicity, complemented by phylogenetic analyses, we identify seven potentially antimicrobial active but non-cytotoxic compounds in terms of mass-to-charge ratios and retention times...
2017: Frontiers in Plant Science
Andrew Adamatzky, Georgios Ch Sirakoulis, Genaro J Martínez, Frantisek Baluška, Stefano Mancuso
Theoretical constructs of logical gates implemented with plant roots are morphological computing asynchronous devices. Values of Boolean variables are represented by plant roots. A presence of a plant root at a given site symbolises the logical True, an absence the logical False. Logical functions are calculated via interaction between roots. Two types of two-inputs-two-outputs gates are proposed: a gate 〈x, y〉→〈xy, x+y〉 where root apexes are guided by gravity and a gate 〈x,y〉→〈x¯y,x〉 where root apexes are guided by humidity...
April 17, 2017: Bio Systems
Mónica L García-Gómez, Eugenio Azpeitia, Elena R Álvarez-Buylla
The study of the concerted action of hormones and transcription factors is fundamental to understand cell differentiation and pattern formation during organ development. The root apical meristem of Arabidopsis thaliana is a useful model to address this. It has a stem cell niche near its tip conformed of a quiescent organizer and stem or initial cells around it, then a proliferation domain followed by a transition domain, where cells diminish division rate before transiting to the elongation zone; here, cells grow anisotropically prior to their final differentiation towards the plant base...
April 2017: PLoS Computational Biology
Michael A Klatt, Gerd E Schröder-Turk, Klaus Mecke
PURPOSE: Structure-property relations, which relate the shape of the microstructure to physical properties such as transport or mechanical properties, need sensitive measures of structure. What are suitable fabric tensors to quantify the shape of anisotropic heterogeneous materials? The mean intercept length is among the most commonly used characteristics of anisotropy in porous media, e. g., of trabecular bone in medical physics. Yet, in this series of two papers we demonstrate that it has conceptual shortcomings that limit the validity of its results...
April 20, 2017: Medical Physics
Michael A Klatt, Gerd E Schröder-Turk, Klaus Mecke
PURPOSE: Structure-property relations, which relate the shape of the microstructure to physical properties such as transport or mechanical properties, need sensitive measures of structure. What are suitable fabric tensors to quantify the shape of anisotropic heterogeneous materials? The mean intercept length is among the most commonly used characteristics of anisotropy in porous media, for example, of trabecular bone in medical physics. METHODS: We analyze the orientation-biased Boolean model, a versatile stochastic model that represents microstructures as overlapping grains with an orientation bias towards a preferred direction...
April 20, 2017: Medical Physics
Abhinav Parihar, Nikhil Shukla, Matthew Jerry, Suman Datta, Arijit Raychowdhury
While Boolean logic has been the backbone of digital information processing, there exist classes of computationally hard problems wherein this paradigm is fundamentally inefficient. Vertex coloring of graphs, belonging to the class of combinatorial optimization, represents one such problem. It is well studied for its applications in data sciences, life sciences, social sciences and technology, and hence, motivates alternate, more efficient non-Boolean pathways towards its solution. Here we demonstrate a coupled relaxation oscillator based dynamical system that exploits insulator-metal transition in Vanadium Dioxide (VO2) to efficiently solve vertex coloring of graphs...
April 19, 2017: Scientific Reports
E Verduci, A Martelli, V L Miniello, M Landi, B Mariani, M Brambilla, L Diaferio, D G Peroni
The aim of this paper is to discuss the current evidence regarding short and long-term health respiratory effects of nutrients and dietary patterns during the first 1000 days from conception. Population of interest included children from birth to two years and their mothers (during pregnancy and lactation). Studies were searched on MEDLINE® and Cochrane database, inserting individually and using the Boolean ANDs and ORs, 'nutrients', 'micronutrients', 'LC-PUFA', 'Mediterranean Diet', 'human milk', 'complementary food', 'pregnancy', 'respiratory disease', 'pulmonary disease', 'asthma', 'epigenetics', 'first 1000 days', 'maternal diet' and 'respiratory health'...
April 12, 2017: Allergologia et Immunopathologia
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