Read by QxMD icon Read


Louis Fippo Fitime, Olivier Roux, Carito Guziolowski, Loïc Paulevé
BACKGROUND: Numerous cellular differentiation processes can be captured using discrete qualitative models of biological regulatory networks. These models describe the temporal evolution of the state of the network subject to different competing transitions, potentially leading the system to different attractors. This paper focusses on the formal identification of states and transitions that are crucial for preserving or pre-empting the reachability of a given behaviour. METHODS: In the context of non-deterministic automata networks, we propose a static identification of so-called bifurcations, i...
2017: Algorithms for Molecular Biology: AMB
Brigitte Michelsen, Eirik Klami Kristianslund, Joseph Sexton, Hilde Berner Hammer, Karen Minde Fagerli, Elisabeth Lie, Ada Wierød, Synøve Kalstad, Erik Rødevand, Frode Krøll, Glenn Haugeberg, Tore K Kvien
OBJECTIVE: To investigate the predictive value of baseline depression/anxiety on the likelihood of achieving joint remission in rheumatoid arthritis (RA) and psoriatic arthritis (PsA) as well as the associations between baseline depression/anxiety and the components of the remission criteria at follow-up. METHODS: We included 1326 patients with RA and 728 patients with PsA from the prospective observational NOR-DMARD study starting first-time tumour necrosis factor inhibitors or methotrexate...
July 21, 2017: Annals of the Rheumatic Diseases
Utku Erdogdu, Faruk Polat, Reda Alhajj
OBJECTIVE: Formulate the induction and control of gene regulatory networks (GRNs) from gene expression data using Partially Observable Markov Decision Processes (POMDPs). METHODS AND MATERIAL: Different approaches exist to model GRNs; they are mostly simulated as mathematical models that represent relationships between genes. Actually, it has been realized that biological functions at the cellular level are controlled by genes; thus, by controlling the behavior of genes, it is possible to regulate these biological functions...
July 18, 2017: Artificial Intelligence in Medicine
Yang Liu, Jinde Cao, Bowen Li, Jianquan Lu
In this brief, we first study the normalization of dynamic-algebraic Boolean networks (DABNs). A new expression for the normalized DABNs is obtained. As applications of this result, the solvability and uniqueness of the solution to DABNs are then investigated. Necessary and sufficient conditions for the solvability and the uniqueness are obtained. In addition, pinning control to ensure the solvability and uniqueness of the solution to DABNs is also studied. Numerical examples are given to illustrate the efficiency of the proposed results...
July 14, 2017: IEEE Transactions on Neural Networks and Learning Systems
David G Behm, James D Young, Joseph H D Whitten, Jonathan C Reid, Patrick J Quigley, Jonathan Low, Yimeng Li, Camila D Lima, Daniel D Hodgson, Anis Chaouachi, Olaf Prieske, Urs Granacher
Numerous national associations and multiple reviews have documented the safety and efficacy of strength training for children and adolescents. The literature highlights the significant training-induced increases in strength associated with youth strength training. However, the effectiveness of youth strength training programs to improve power measures is not as clear. This discrepancy may be related to training and testing specificity. Most prior youth strength training programs emphasized lower intensity resistance with relatively slow movements...
2017: Frontiers in Physiology
Xiangmeng Qu, Shaopeng Wang, Zhilei Ge, Jianbang Wang, Guangbao Yao, Jiang Li, Xiaolei Zuo, Jiye Shi, Shiping Song, Lihua Wang, Li Li, Hao Pei, Chunhai Fan
Programmable remodelling of cell surfaces enables high-precision regulation of cell behavior. In this work, we developed in-vitro constructed DNA-based chemical reaction networks (CRNs) to program on-chip cell adhesion. We found that the RGD-functionalized DNA CRNs are entirely non-invasive when interfaced with the fluidic mosaic membrane of living cells. DNA toehold with different lengths could tunably alter the release kinetics of cells, which shows rapid release in minutes with the use of a 6-base toehold...
July 17, 2017: Journal of the American Chemical Society
Christine Mayer, Thomas F Hansen
Evolvability and robustness are crucial for the origin and maintenance of complex organisms, but may not be simultaneously achievable as robust traits are also hard to change. Andreas Wagner has proposed a solution to this paradox by arguing that the many-to-few aspect of genotype-phenotype maps creates neutral networks of genotypes coding for the same phenotype. Phenotypes with large networks are genetically robust, but they may also have more neighboring phenotypes and thus higher evolvability. In this paper, we explore the generality of this idea by sampling large numbers of random genotype-phenotype maps for Boolean genotypes and phenotypes...
July 11, 2017: Journal of Theoretical Biology
Pooja Patnaik Kuppili, Harshini Manohar, Raman Deep Pattanayak, Rajesh Sagar, Balaji Bharadwaj, Preeti Kandasamy
INTRODUCTION: Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder with no clear etiopathogenesis. Owing to unique socio cultural milieu of India, it is worthwhile reviewing research on ADHD from India and comparing findings with global research. Thereby, we attempted to provide a comprehensive overview of research on ADHD from India. METHODS: A boolean search of articles published in English from September 1966 to January 2017 on electronic search engines Google Scholar, PubMed, IndMED, MedIND, using the search terms "ADHD", "Attention Deficit and Hyperactivity Disorder", "Hyperactivity" ,"Child psychiatry", "Hyperkinetic disorder", "Attention Deficit Disorder", "India"was carried out and peer - reviewed studies conducted among human subjects in India were included for review...
July 5, 2017: Asian Journal of Psychiatry
Jerome Charton, Mathieu Laurentjoye, Youngjun Kim
PURPOSE: Boolean operations in computer-aided design or computer graphics are a set of operations (e.g. intersection, union, subtraction) between two objects (e.g. a patient model and an implant model) that are important in performing accurate and reproducible virtual surgical planning. This requires accurate and robust techniques that can handle various types of data, such as a surface extracted from volumetric data, synthetic models, and 3D scan data. METHODS: This article compares the performance of the proposed method (Boolean operations by a robust, exact, and simple method between two colliding shells (BORES)) and an existing method based on the Visualization Toolkit (VTK)...
July 12, 2017: International Journal of Computer Assisted Radiology and Surgery
Max M Owens, Michael T Amlung, Steven R H Beach, Lawrence H Sweet, James MacKillop
BACKGROUND: Delayed reward discounting (DRD), the degree to which future rewards are discounted relative to immediate rewards, is used as an index of impulsive decision-making and has been associated with a number of problematic health behaviors. Given the robust behavioral association between DRD and addictive behavior, there is an expanding literature investigating the differences in the functional and structural correlates of DRD in the brain between addicted and healthy individuals...
July 11, 2017: Systematic Reviews
Ankit Shukla, Arnab Bhattacharyya, Lakshmanan Kuppusamy, Mandayam Srivas, Mukund Thattai
A eukaryotic cell contains multiple membrane-bound compartments. Transport vesicles move cargo between these compartments, just as trucks move cargo between warehouses. These processes are regulated by specific molecular interactions, as summarized in the Rothman-Schekman-Sudhof model of vesicle traffic. The whole structure can be represented as a transport graph: each organelle is a node, and each vesicle route is a directed edge. What constraints must such a graph satisfy, if it is to represent a biologically realizable vesicle traffic network? Graph connectedness is an informative feature: 2-connectedness is necessary and sufficient for mass balance, but stronger conditions are required to ensure correct molecular specificity...
2017: PloS One
Jianbing Shen, Jianteng Peng, Xingping Dong, Ling Shao, Fatih Porikli
A novel energy minimization method for general higher-order binary energy functions is proposed in this paper. We first relax a discrete higher-order function to a continuous one, and use the Taylor expansion to obtain an approximate lower-order function, which is optimized by the quadratic pseudo-boolean optimization (QPBO) or other discrete optimizers. The minimum solution of this lower-order function is then used as a new local point, where we expand the original higher-order energy function again. Our algorithm does not restrict to any specific form of the higher-order binary function or bring in extra auxiliary variables...
July 3, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
M Schoels, F Alasti, J S Smolen, D Aletaha
BACKGROUND: Stringent remission criteria are crucial in rheumatoid arthritis (RA) assessment. Disease activity score in 28 joints (DAS28)-remission has not been included among American College of Rheumatology/European League Against Rheumatism definitions, because of its association with significant residual disease activity, partly due to high weighting of acute-phase reactants (APR). New, more stringent cut-points for DAS28-remission have recently been proposed that are suggested to reflect remission by clinical and simplified disease activity indices (clinical disease activity index (CDAI), simple disease activity index (SDAI))...
July 4, 2017: Arthritis Research & Therapy
Devon J Godfrey, Bhavik N Patel, Justus D Adamson, Ergys Subashi, Joseph K Salama, Manisha Palta
PURPOSE: Bolus-tracked multiphasic contrast computed tomography (CT) is often used in diagnostic radiology to enhance the visibility of pancreas tumors, but is uncommon in radiation therapy pancreas CT simulation, and its impact on gross tumor volume (GTV) delineation is unknown. This study evaluates the lesion conspicuity and consistency of pancreas stereotactic body radiation therapy (SBRT) GTVs contoured in the different contrast phases of triphasic CT simulation scans. METHODS AND MATERIALS: Triphasic, bolus-tracked planning CT simulation scans of 10 consecutive pancreas SBRT patients were acquired, yielding images of the pancreas during the late arterial (LA), portal venous (PV), and either the early arterial or delayed phase...
April 13, 2017: Practical Radiation Oncology
Ru-Ru Gao, Shuo Shi, Yu-Jie Li, Maierhaba Wumaier, Xiao-Chun Hu, Tian-Ming Yao
Novel supramolecular coordination polymer nanoparticles (CPNs) were synthesized via the self-assembly of guanosine monophosphate (GMP) and lanthanide ions (Ln(3+), including Tb(3+), Eu(3+) and Ce(3+)) in aqueous solution. These CPNs (GMP/Tb(3+), GMP/Eu(3+) and GMP/Ce(3+)) have an identical coordination environment but exhibit completely different luminescence properties responding to external stimuli such as dipicolinic acid (DPA), ethylene diamine tetraacetic acid (EDTA), pH and metal ions, which has inspired us to tune the emission color of the CPNs and perform multiple logic operations...
July 13, 2017: Nanoscale
Hao Chen, Guanyu Wang, Rahul Simha, Chenghang Du, Chen Zeng
This corrects the article DOI: 10.1038/srep20067.
June 30, 2017: Scientific Reports
Lucia Bühlmayer, Daniel Birrer, Philipp Röthlin, Oliver Faude, Lars Donath
BACKGROUND: Mindfulness as a present-oriented form of mental training affects cognitive processes and is increasingly considered meaningful for sport psychological training approaches. However, few intervention studies have examined the effects of mindfulness practice on physiological and psychological performance surrogates or on performance outcomes in sports. OBJECTIVE: The aim of the present meta-analytical review was to examine the effects of mindfulness practice or mindfulness-based interventions on physiological and psychological performance surrogates and on performance outcomes in sports in athletes over 15 years of age...
June 29, 2017: Sports Medicine
Rebecca McDonald, Nancy D Campbell, John Strang
BACKGROUND: Opioid overdose is a major cause of mortality, but injury and fatal outcomes can be prevented by timely administration of the opioid antagonist naloxone. Pre-provision of naloxone to opioid users and family members (take-home naloxone, THN) was first proposed in 1996, and WHO Guidelines were issued in 2014. While widespread in some countries, THN is minimally available or absent elsewhere. This review traces the development of THN over twenty years, from speculative harm reduction proposal to public health strategy...
May 25, 2017: Drug and Alcohol Dependence
E Salagre, B Solé, Y Tomioka, B S Fernandes, D Hidalgo-Mazzei, M Garriga, E Jimenez, J Sanchez-Moreno, E Vieta, I Grande
BACKGROUND: Cognitive symptoms in Major Depressive Disorder (MDD) are persistent and commonly entail neurocognitive impairment and a decline in quality of life. This systematic review gathers the current scientific evidence on therapeutic strategies for neuropsychological impairment in MDD. METHOD: A systematic search on PubMed, PsycINFO and was carried out on December 2016 according to PRISMA using Boolean terms to identify interventions for the treatment of cognitive dysfunction in MDD...
October 15, 2017: Journal of Affective Disorders
Rongjian Liu, Jianquan Lu, Yang Liu, Jinde Cao, Zheng-Guang Wu
In this brief, we study the delayed feedback stabilization problem for Boolean control networks (BCNs) with state delay. Using the semi-tensor product of matrices, some necessary and sufficient conditions are obtained. For the stabilization of BCNs, detailed procedure to construct the feedback controllers is also presented. We further derive the number of different feedback controllers, which can successfully stabilize the BCN in a finite time. Finally, an illustrative example is presented to show the effectiveness of our method...
June 22, 2017: IEEE Transactions on Neural Networks and Learning Systems
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"