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https://www.readbyqxmd.com/read/29347631/phase-transitions-in-restricted-boltzmann-machines-with-generic-priors
#1
Adriano Barra, Giuseppe Genovese, Peter Sollich, Daniele Tantari
We study generalized restricted Boltzmann machines with generic priors for units and weights, interpolating between Boolean and Gaussian variables. We present a complete analysis of the replica symmetric phase diagram of these systems, which can be regarded as generalized Hopfield models. We underline the role of the retrieval phase for both inference and learning processes and we show that retrieval is robust for a large class of weight and unit priors, beyond the standard Hopfield scenario. Furthermore, we show how the paramagnetic phase boundary is directly related to the optimal size of the training set necessary for good generalization in a teacher-student scenario of unsupervised learning...
October 2017: Physical Review. E
https://www.readbyqxmd.com/read/29342035/systematic-review-of-hearing-preservation-after-radiotherapy-for-vestibular-schwannoma
#2
Adam R Coughlin, Tyler J Willman, Samuel P Gubbels
OBJECTIVE: To determine the long-term hearing preservation rate for spontaneous vestibular schwannoma treated by primary radiotherapy. DATA SOURCES: The MEDLINE/PubMed, Web of Science, Cochrane Reviews, and EMBASE databases were searched using a comprehensive Boolean keyword search developed in conjunction with a scientific librarian. English language papers published from 2000 to 2016 were evaluated. STUDY SELECTION: Inclusion criteria: full articles, pretreatment and posttreatment audiograms or audiogram based scoring system, vestibular schwannoma only tumor type, reported time to follow-up, published after 1999, use of either Gamma Knife or linear accelerator radiotherapy...
January 16, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29337284/method-for-identification-of-sensitive-nodes-in-boolean-models-of-biological-networks
#3
Pooja A Dnyane, Shraddha S Puntambekar, Chetan J Gadgil
Biological systems are often represented as Boolean networks and analysed to identify sensitive nodes which on perturbation disproportionately change a predefined output. There exist different kinds of perturbation methods: perturbation of function, perturbation of state and perturbation in update scheme. Nodes may have defects in interpretation of the inputs from other nodes and calculation of the node output. To simulate these defects and systematically assess their effect on the system output, two new function perturbations, referred to as 'not of function' and 'function of not', are introduced...
February 2018: IET Systems Biology
https://www.readbyqxmd.com/read/29334149/evidence-based-practice-readiness-a-concept-analysis
#4
Jessica D Schaefer, John M Welton
AIM: To analyse and define the concept "evidence based practice readiness" in nurses. BACKGROUND: Evidence based practice readiness is a term commonly used in health literature, but without a clear understanding of what readiness means. Concept analysis is needed to define the meaning of evidence based practice readiness. METHOD: A concept analysis was conducted using Walker and Avant's method to clarify the defining attributes of evidence based practice readiness as well as antecedents and consequences...
January 15, 2018: Journal of Nursing Management
https://www.readbyqxmd.com/read/29332104/assessment-of-the-fit-of-removable-partial-denture-fabricated-by-computer-aided-designing-computer-aided-manufacturing-technology
#5
Khalid A O Arafa
To assess the level of evidence that supports the quality of fit for removable partial denture (RPD) fabricated by computer-aided designing/computer aided manufacturing (CAD/CAM) and rapid prototyping (RP) technology. Methods: An electronic search was performed in Google Scholar, PubMed, and Cochrane library search engines, using Boolean operators. All articles published in English and published in the period from 1950 until April 2017 were eligible to be included in this review. The total number of articles contained the search terms in any part of the article (including titles, abstracts, or article texts) were screened, which resulted in 214 articles...
January 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29322926/construction-and-analysis-of-gene-gene-dynamics-influence-networks-based-on-a-boolean-model
#6
Maulida Mazaya, Hung-Cuong Trinh, Yung-Keun Kwon
BACKGROUND: Identification of novel gene-gene relations is a crucial issue to understand system-level biological phenomena. To this end, many methods based on a correlation analysis of gene expressions or structural analysis of molecular interaction networks have been proposed. They have a limitation in identifying more complicated gene-gene dynamical relations, though. RESULTS: To overcome this limitation, we proposed a measure to quantify a gene-gene dynamical influence (GDI) using a Boolean network model and constructed a GDI network to indicate existence of a dynamical influence for every ordered pair of genes...
December 21, 2017: BMC Systems Biology
https://www.readbyqxmd.com/read/29317919/impact-on-process-results-of-clinical-decision-support-systems-cdsss-applied-to-medication-use-overview-of-systematic-reviews
#7
Wálleri C Reis, Aline F Bonetti, Wallace E Bottacin, Alcindo S Reis, Thaís T Souza, Roberto Pontarolo, Cassyano J Correr, Fernando Fernandez-Llimos
Objective: The purpose of this overview (systematic review of systematic reviews) is to evaluate the impact of clinical decision support systems (CDSS) applied to medication use in the care process. Methods: A search for systematic reviews that address CDSS was performed on Medline following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and Cochrane recommendations. Terms related to CDSS and systematic reviews were used in combination with Boolean operators and search field tags to build the electronic search strategy...
October 2017: Pharmacy Practice
https://www.readbyqxmd.com/read/29311689/multi-valued-and-fuzzy-logic-realization-using-taox-memristive-devices
#8
Debjyoti Bhattacharjee, Wonjoo Kim, Anupam Chattopadhyay, Rainer Waser, Vikas Rana
Among emerging non-volatile storage technologies, redox-based resistive switching Random Access Memory (ReRAM) is a prominent one. The realization of Boolean logic functionalities using ReRAM adds an extra edge to this technology. Recently, 7-state ReRAM devices were used to realize ternary arithmetic circuits, which opens up the computing space beyond traditional binary values. In this manuscript, we report realization of multi-valued and fuzzy logic operators with a representative application using ReRAM devices...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29307099/boolean-network-modeling-in-systems-pharmacology
#9
Peter Bloomingdale, Van Anh Nguyen, Jin Niu, Donald E Mager
Quantitative systems pharmacology (QSP) is an emerging discipline that aims to discover how drugs modulate the dynamics of biological components in molecular and cellular networks and the impact of those perturbations on human pathophysiology. The integration of systems-based experimental and computational approaches is required to facilitate the advancement of this field. QSP models typically consist of a series of ordinary differential equations (ODE). However, this mathematical framework requires extensive knowledge of parameters pertaining to biological processes, which is often unavailable...
January 6, 2018: Journal of Pharmacokinetics and Pharmacodynamics
https://www.readbyqxmd.com/read/29297345/model-checking-optimal-finite-horizon-control-for-probabilistic-gene-regulatory-networks
#10
Ou Wei, Zonghao Guo, Yun Niu, Wenyuan Liao
BACKGROUND: Probabilistic Boolean networks (PBNs) have been proposed for analyzing external control in gene regulatory networks with incorporation of uncertainty. A context-sensitive PBN with perturbation (CS-PBNp), extending a PBN with context-sensitivity to reflect the inherent biological stability and random perturbations to express the impact of external stimuli, is considered to be more suitable for modeling small biological systems intervened by conditions from the outside. In this paper, we apply probabilistic model checking, a formal verification technique, to optimal control for a CS-PBNp that minimizes the expected cost over a finite control horizon...
December 14, 2017: BMC Systems Biology
https://www.readbyqxmd.com/read/29297290/texture-based-skin-lesion-abruptness-quantification-to-detect-malignancy
#11
Recep Erol, Mustafa Bayraktar, Sinan Kockara, Sertan Kaya, Tansel Halic
BACKGROUND: Abruptness of pigment patterns at the periphery of a skin lesion is one of the most important dermoscopic features for detection of malignancy. In current clinical setting, abrupt cutoff of a skin lesion determined by an examination of a dermatologist. This process is subjective, nonquantitative, and error-prone. We present an improved computational model to quantitatively measure abruptness of a skin lesion over our previous method. To achieve this, we quantitatively analyze the texture features of a region within the lesion boundary...
December 28, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/29289034/economic-networks-heterogeneity-induced-vulnerability-and-loss-of-synchronization
#12
Célian Colon, Michael Ghil
Interconnected systems are prone to propagation of disturbances, which can undermine their resilience to external perturbations. Propagation dynamics can clearly be affected by potential time delays in the underlying processes. We investigate how such delays influence the resilience of production networks facing disruption of supply. Interdependencies between economic agents are modeled using systems of Boolean delay equations (BDEs); doing so allows us to introduce heterogeneity in production delays and in inventories...
December 2017: Chaos
https://www.readbyqxmd.com/read/29288436/the-relationships-between-internal-and-external-measures-of-training-load-and-intensity-in-team-sports-a-meta-analysis
#13
REVIEW
Shaun J McLaren, Tom W Macpherson, Aaron J Coutts, Christopher Hurst, Iain R Spears, Matthew Weston
BACKGROUND: The associations between internal and external measures of training load and intensity are important in understanding the training process and the validity of specific internal measures. OBJECTIVES: We aimed to provide meta-analytic estimates of the relationships, as determined by a correlation coefficient, between internal and external measures of load and intensity during team-sport training and competition. A further aim was to examine the moderating effects of training mode on these relationships...
December 29, 2017: Sports Medicine
https://www.readbyqxmd.com/read/29277602/a-circuit-preserving-mapping-from-multilevel-to-boolean-dynamics
#14
Adrien Fauré, Shizuo Kaji
Many discrete models of biological networks rely exclusively on Boolean variables and many tools and theorems are available for analysis of strictly Boolean models. However, multilevel variables are often required to account for threshold effects, in which knowledge of the Boolean case does not generalise straightforwardly. This motivated the development of conversion methods for multilevel to Boolean models. In particular, Van Ham's method has been shown to yield a one-to-one, neighbour and regulation preserving dynamics, making it the de facto standard approach to the problem...
December 22, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29274691/overweight-and-obesity-effectiveness-of-interventions-in-adults
#15
Juana María Gómez Puente, Mercedes Martínez-Marcos
OBJECTIVE: To identify the most effective interventions in overweight and obese adults. METHOD: A narrative review through a search of the literature in databases PubMed, Cochrane, Joanna Briggs Institute, EMBASE, Cuiden y Cinahl with free and controlled language (MeSH terms) using Boolean operators AND and NOT. The research was limited to articles published between 2007 and 2015. Eighteen articles were selected based on the established inclusion and exclusion criteria...
December 20, 2017: Enfermería Clínica
https://www.readbyqxmd.com/read/29261204/nanomolar-level-selective-dual-channel-sensing-of-cu2-and-cn-from-an-aqueous-medium-by-an-opto-electronic-chemoreceptor
#16
Suparna Paul, Pritam Ghosh, Samuzal Bhuyan, Subhra Kanti Mukhopadhyay, Priyabrata Banerjee
A dual-channel chromogenic and fluorogenic fused-aromatic-system-based chemoreceptor (2-(benzo[d]thiazol-2-yl)-1-((pyren-8-yl)methylene)hydrazine) (TyM) was designed for ditopic sensitivity towards heavy and transition metal ions (HTMs), such as Cu2+, in an aqueous medium and lethal CN- in a semi-aqueous medium. The chemoreceptor displayed proclivity towards the targeted analytes with a distinct optical response (yellow to colourless in the case of Cu2+ and yellow to bright red for CN-). TyM formed a 2 : 1 adduct with Cu2+ with a detection limit of 40 nM...
December 20, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29259574/the-relationship-between-binge-eating-disorder-and-suicidality-a-systematic-review
#17
REVIEW
Chiara Conti, Roberta Lanzara, Mattia Scipioni, Marzia Iasenza, Maria T Guagnano, Mario Fulcheri
Background: We carried out a systematic review analyzing the relation between binge eating disorder (BED), a recent addition to the eating disorders in DSM-5, and suicidality (i.e., suicidal ideation or attempted and/or committed suicide) by synthesizing the relevant studies' qualitative data. Methods: We conducted, according to PRISMA guidelines, a systematic search of the literature on PubMed, Scopus, ISI Web of Science, PsycINFO, Google Scholar, and ScienceDirect. Search terms were "binge eating disorder" combined with the "AND" Boolean operator and "suicid*...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29259222/proposal-for-nanoscale-cascaded-plasmonic-majority-gates-for-non-boolean-computation
#18
Sourav Dutta, Odysseas Zografos, Surya Gurunarayanan, Iuliana Radu, Bart Soree, Francky Catthoor, Azad Naeemi
Surface-plasmon-polariton waves propagating at the interface between a metal and a dielectric, hold the key to future high-bandwidth, dense on-chip integrated logic circuits overcoming the diffraction limitation of photonics. While recent advances in plasmonic logic have witnessed the demonstration of basic and universal logic gates, these CMOS oriented digital logic gates cannot fully utilize the expressive power of this novel technology. Here, we aim at unraveling the true potential of plasmonics by exploiting an enhanced native functionality - the majority voter...
December 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29258225/stability-of-signaling-pathways-during-aging-a-boolean-network-approach
#19
Julian Daniel Schwab, Lea Siegle, Silke Daniela Kühlwein, Michael Kühl, Hans Armin Kestler
Biological pathways are thought to be robust against a variety of internal and external perturbations. Fail-safe mechanisms allow for compensation of perturbations to maintain the characteristic function of a pathway. Pathways can undergo changes during aging, which may lead to changes in their stability. Less stable or less robust pathways may be consequential to or increase the susceptibility of the development of diseases. Among others, NF- κ B signaling is a crucial pathway in the process of aging. The NF- κ B system is involved in the immune response and dealing with various internal and external stresses...
December 18, 2017: Biology
https://www.readbyqxmd.com/read/29243823/pathways-to-medical-home-recognition-a-qualitative-comparative-analysis-of-the-pcmh-transformation-process
#20
Peter Mendel, Emily K Chen, Harold D Green, Courtney Armstrong, Justin W Timbie, Amii M Kress, Mark W Friedberg, Katherine L Kahn
OBJECTIVE: To understand the process of practice transformation by identifying pathways for attaining patient-centered medical home (PCMH) recognition. DATA SOURCES/STUDY SETTING: The CMS Federally Qualified Health Center (FQHC) Advanced Primary Care Practice Demonstration was designed to help FQHCs achieve NCQA Level 3 PCMH recognition and improve patient outcomes. We used a stratified random sample of 20 (out of 503) participating sites for this analysis. STUDY DESIGN: We developed a conceptual model of structural, cultural, and implementation factors affecting PCMH transformation based on literature and initial qualitative interview themes...
December 15, 2017: Health Services Research
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