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https://www.readbyqxmd.com/read/28327650/erratum-the-combination-of-the-functionalities-of-feedback-circuits-is-determinant-for-the-attractors-number-and-size-in-pathway-like-boolean-networks
#1
Eugenio Azpeitia, Stalin Muñoz, Daniel González-Tokman, Mariana Esther Martínez-Sánchez, Nathan Weinstein, Aurélien Naldi, Elena R Álvarez-Buylla, David A Rosenblueth, Luis Mendoza
No abstract text is available yet for this article.
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28324806/social-networking-site-sns-use-by-adolescent-mothers-can-social-support-and-social-capital-be-enhanced-by-online-social-networks-a-structured-review-of-the-literature
#2
REVIEW
Samantha Nolan, Joyce Hendricks, Sally Ferguson, Amanda Towell
AIMS AND OBJECTIVES: to critically appraise the available literature and summarise the evidence relating to adolescent mothers' use of social networking sites in terms of any social support and social capital they may provide and to identify areas for future exploration. BACKGROUND: social networking sites have been demonstrated to provide social support to marginalised individuals and provide psycho-social benefits to members of such groups. Adolescent mothers are at risk of; social marginalisation; anxiety disorders and depressive symptoms; and poorer health and educational outcomes for their children...
March 7, 2017: Midwifery
https://www.readbyqxmd.com/read/28303791/integer-programming-based-method-for-observability-of-singleton-attractors-in-boolean-networks
#3
Xiaoqing Cheng, Yushan Qiu, Wenpin Hou, Wai-Ki Ching
Boolean network (BN) is a popular mathematical model for revealing the behaviour of a genetic regulatory network. Furthermore, observability, an important network feature, plays a significant role in understanding the underlying network. Several studies have been done on analysis of observability of BNs and complex networks. However, the observability of attractor cycles, which can serve as biomarker detection, has not yet been addressed in the literature. This is an important, interesting and challenging problem that deserves a detailed study...
February 2017: IET Systems Biology
https://www.readbyqxmd.com/read/28303788/dynamics-and-robustness-of-the-cardiac-progenitor-cell-induced-pluripotent-stem-cell-network-during-cell-phenotypes-transition
#4
Yuangen Yao, Chengzhang Ma, Haiyou Deng, Quan Liu, Wei Cao, Rong Gui, Tianquan Feng, Ming Yi
Robustness is a fundamental characteristic of biological systems since all living systems need to adapt to internal or external perturbations, unpredictable environments, stochastic events and unreliable components, and so on. A long-term challenge in systems biology is to reveal the origin of robustness underlying molecular regulator network. In this study, a simple Boolean model is used to investigate the global dynamic properties and robustness of cardiac progenitor cell (CPC) induced pluripotent stem cell network that governs reprogramming and directed differentiation process...
February 2017: IET Systems Biology
https://www.readbyqxmd.com/read/28298874/a-new-kind-of-bernstein-schurer-stancu-kantorovich-type-operators-based-on-q-integers
#5
Ruchi Chauhan, Nurhayat Ispir, P N Agrawal
Agrawal et al. (Boll. Unione Mat. Ital. 8:169-180, 2015) introduced a Stancu-type Kantorovich modification of the operators proposed by Ren and Zeng (Bull. Korean Math. Soc. 50(4):1145-1156, 2013) and studied a basic convergence theorem by using the Bohman-Korovokin criterion, the rate of convergence involving the modulus of continuity, and the Lipschitz function. The concern of this paper is to obtain Voronoskaja-type asymptotic result by calculating an estimate of fourth order central moment for these operators and discuss the rate of convergence for the bivariate case by using the complete and partial moduli of continuity and the degree of approximation by means of a Lipschitz-type function and the Peetre K-functional...
2017: J Inequal Appl
https://www.readbyqxmd.com/read/28297900/transient-dynamics-and-their-control-in-time-delay-autonomous-boolean-ring-networks
#6
Johannes Lohmann, Otti D'Huys, Nicholas D Haynes, Eckehard Schöll, Daniel J Gauthier
Biochemical systems with switch-like interactions, such as gene regulatory networks, are well modeled by autonomous Boolean networks. Specifically, the topology and logic of gene interactions can be described by systems of continuous piecewise-linear differential equations, enabling analytical predictions of the dynamics of specific networks. However, most models do not account for time delays along links associated with spatial transport, mRNA transcription, and translation. To address this issue, we have developed an experimental test bed to realize a time-delay autonomous Boolean network with three inhibitory nodes, known as a repressilator, and use it to study the dynamics that arise as time delays along the links vary...
February 2017: Physical Review. E
https://www.readbyqxmd.com/read/28287741/ph-elicited-luminescence-functionalities-of-carbon-dots-mechanistic-insights
#7
Sharmistha Dutta Choudhury, Jiddhu M Chethodil, Poojan Milan Gharat, Praseetha P K, Haridas Pal
Remarkable and systematic pH dependent changes are observed in the absorption and emission spectra of carbon dots derived for the first time, from lemon juice, a natural bio-resource. Detailed photophysical studies of these novel carbon dots (henceforth referred as LD), in conjunction with FTIR spectra, reveal that among the two possible prototropic equilibria, phenol ↔ phenolate and carboxylic ↔ carboxylate, that occur at the surface of LD; it is the former that is actually coupled with the emissive moiety and directly involved in determining the nature of the electronic energy levels and the associated optical transitions...
March 13, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28269650/a-boolean-approach-to-bacterial-chemotaxis
#8
Anuj Deshpande, Sibendu Samanta, Haimabati Das, Ritwik Kumar Layek
Bacterium such as Escherichia coli (E. coli) show biased Brownian motion in different chemical concentration gradients. This chemical sensitive motility or chemotaxis has gained considerable interest among scientists for some remarkable features such as chemo-sensory dynamic range, adaptation, diffusion and drift. A Boolean model of the whole chemotaxis process has been developed in this manuscript. The response of the circuit is in accordance with the experimental results available in the literature, providing indirect validation of the model...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268604/learning-a-probabilistic-boolean-network-model-from-biological-pathways-and-time-series-expression-data
#9
Vardaan Pahuja, Ritwik Kumar Layek, Pabitra Mitra
The problem of inferring a stochastic model for gene regulatory networks is addressed here. The prior biological data includes biological pathways and time-series expression data. We propose a novel algorithm to use both of these data to construct a Probabilistic Boolean Network (PBN) which models the observed dynamics of genes with a high degree of precision. Our algorithm constructs a pathway tree and uses the time-series expression data to select an optimal level of tree, whose nodes are used to infer the PBN...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28265989/reconstruction-of-an-immune-dynamic-model-to-simulate-the-contrasting-role-of-auxin-and-cytokinin-in-plant-immunity
#10
Martin Kaltdorf, Thomas Dandekar, Muhammad Naseem
In order to increase our understanding of biological dependencies in plant immune signaling pathways, the known interactions involved in plant immune networks are modeled. This allows computational analysis to predict the functions of growth related hormones in plant-pathogen interaction. The SQUAD (Standardized Qualitative Dynamical Systems) algorithm first determines stable system states in the network and then use them to compute continuous dynamical system states. Our reconstructed Boolean model encompassing hormone immune networks of Arabidopsis thaliana (Arabidopsis) and pathogenicity factors injected by model pathogen Pseudomonas syringae pv...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28264816/eular-recommendations-for-the-management-of-rheumatoid-arthritis-with-synthetic-and-biological-disease-modifying-antirheumatic-drugs-2016-update
#11
Josef S Smolen, Robert Landewé, Johannes Bijlsma, Gerd Burmester, Katerina Chatzidionysiou, Maxime Dougados, Jackie Nam, Sofia Ramiro, Marieke Voshaar, Ronald van Vollenhoven, Daniel Aletaha, Martin Aringer, Maarten Boers, Chris D Buckley, Frank Buttgereit, Vivian Bykerk, Mario Cardiel, Bernard Combe, Maurizio Cutolo, Yvonne van Eijk-Hustings, Paul Emery, Axel Finckh, Cem Gabay, Juan Gomez-Reino, Laure Gossec, Jacques-Eric Gottenberg, Johanna M W Hazes, Tom Huizinga, Meghna Jani, Dmitry Karateev, Marios Kouloumas, Tore Kvien, Zhanguo Li, Xavier Mariette, Iain McInnes, Eduardo Mysler, Peter Nash, Karel Pavelka, Gyula Poór, Christophe Richez, Piet van Riel, Andrea Rubbert-Roth, Kenneth Saag, Jose da Silva, Tanja Stamm, Tsutomu Takeuchi, René Westhovens, Maarten de Wit, Désirée van der Heijde
Recent insights in rheumatoid arthritis (RA) necessitated updating the European League Against Rheumatism (EULAR) RA management recommendations. A large international Task Force based decisions on evidence from 3 systematic literature reviews, developing 4 overarching principles and 12 recommendations (vs 3 and 14, respectively, in 2013). The recommendations address conventional synthetic (cs) disease-modifying antirheumatic drugs (DMARDs) (methotrexate (MTX), leflunomide, sulfasalazine); glucocorticoids (GC); biological (b) DMARDs (tumour necrosis factor (TNF)-inhibitors (adalimumab, certolizumab pegol, etanercept, golimumab, infliximab), abatacept, rituximab, tocilizumab, clazakizumab, sarilumab and sirukumab and biosimilar (bs) DMARDs) and targeted synthetic (ts) DMARDs (Janus kinase (Jak) inhibitors tofacitinib, baricitinib)...
March 6, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28264731/surge-capacity-of-hospitals-in-emergencies-and-disasters-with-a-preparedness-approach-a-systematic-review
#12
Hojjat Sheikhbardsiri, Ahmad Reza Raeisi, Mahmood Nekoei-Moghadam, Fatemeh Rezaei
OBJECTIVE: Surge capacity is one of the most important components of hospital preparedness for responding to emergencies and disasters. The ability to provide health and medical care during a sudden increase in the number of patients or victims of disasters is a main concern of hospitals. We aimed to perform a systematic review of hospital surge capacity in emergencies and disasters with a preparedness approach. METHODS: A systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines...
March 7, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28263351/effects-of-simulation-on-nursing-student-stress-an-integrative-review
#13
Melody L Cantrell, Susan L Meyer, Victoria Mosack
BACKGROUND: The effects of stress on nursing students' health and learning is important to educators. The purpose of this review was to critically integrate the literature related to the stress that nursing students experience regarding high-fidelity simulation (HFS). METHOD: Literature from multiple search engines and databases was systematically searched. Keywords and Boolean combinations included nursing students, simulation, stress, anxiety, and self-efficacy...
March 1, 2017: Journal of Nursing Education
https://www.readbyqxmd.com/read/28261713/nonvolatile-reconfigurable-sequential-logic-in-a-hfo2-resistive-random-access-memory-array
#14
Ya-Xiong Zhou, Yi Li, Yu-Ting Su, Zhuo-Rui Wang, Ling-Yi Shih, Ting-Chang Chang, Kuan-Chang Chang, Shi-Bing Long, Simon M Sze, Xiang-Shui Miao
Resistive random access memory (RRAM) based reconfigurable logic provides a temporal programmable dimension to realize Boolean logic functions and is regarded as a promising route to build non-von Neumann computing architecture. In this work, a reconfigurable operation method is proposed to perform nonvolatile sequential logic in a HfO2-based RRAM array. Eight kinds of Boolean logic functions can be implemented within the same hardware fabrics. During the logic computing processes, the RRAM devices in an array are flexibly configured in a bipolar or complementary structure...
March 6, 2017: Nanoscale
https://www.readbyqxmd.com/read/28261143/improving-major-depressive-episode-assessment-a-new-tool-developed-by-formal-psychological-assessment
#15
Francesca Serra, Andrea Spoto, Marta Ghisi, Giulio Vidotto
Aim: Major depressive episode (MDE) can manifest with different features. Discriminating between different types of MDEs is crucial for proper treatment. The aim of this study is to propose a new tool for MDE assessment in bipolar disorder (BD) or major depressive disorder (MDD) to overcome some limitations of current rating scales. The proposed tool investigates all of the clinical features of different MDEs and gives qualitative information, differentiating patients with the same score but different symptoms and psychopathology severity...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28253403/visualization-of-dietary-patterns-and-their-associations-with-age-related-macular-degeneration
#16
Chung-Jung Chiu, Min-Lee Chang, Tricia Li, Gary Gensler, Allen Taylor
Purpose: We aimed to visualize the relationship of predominant dietary patterns and their associations with AMD. Methods: A total of 8103 eyes from 4088 participants in the baseline Age-Related Eye Disease Study (AREDS) were classified into three groups: control (n = 2739), early AMD (n = 4599), and advanced AMD (n = 765). Using principle component analysis, two major dietary patterns and eight minor dietary patterns were characterized. Applying logistic regression in our analysis, we related dietary patterns to the prevalence of AMD...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28252838/new-graduate-registered-nurses-knowledge-of-patient-safety-and-practice-a-literature-review
#17
REVIEW
Melanie Murray, Deborah Sundin
AIMS AND OBJECTIVES: To critically appraise available literature and summarise evidence pertaining to the patient safety knowledge and practices of new graduate registered nurses. BACKGROUND: Responsibility for patient safety should not be limited to the practice of the bedside nurses, rather the responsibility of all in the healthcare system. Previous research identified lapses in safety across the healthcare, more specifically with new practitioners. Understanding these gaps and what may be employed to counteract them is vital to ensuring patient safety...
March 2, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28252524/development-and-prospective-validation-of-tools-to-accurately-identify-neurosurgical-and-critical-care-events-in-children-with-traumatic-brain-injury
#18
Tellen D Bennett, Peter E DeWitt, Rebecca R Dixon, Cory Kartchner, Yamila Sierra, Diane Ladell, Rajendu Srivastava, Jay Riva-Cambrin, Allison Kempe, Desmond K Runyan, Heather T Keenan, J Michael Dean
OBJECTIVE: To develop and validate case definitions (computable phenotypes) to accurately identify neurosurgical and critical care events in children with traumatic brain injury. DESIGN: Prospective observational cohort study, May 2013 to September 2015. SETTING: Two large U.S. children's hospitals with level 1 Pediatric Trauma Centers. PATIENTS: One hundred seventy-four children less than 18 years old admitted to an ICU after traumatic brain injury...
March 1, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28249395/polynomial-time-solution-of-prime-factorization-and-np-complete-problems-with-digital-memcomputing-machines
#19
Fabio L Traversa, Massimiliano Di Ventra
We introduce a class of digital machines, we name Digital Memcomputing Machines, (DMMs) able to solve a wide range of problems including Non-deterministic Polynomial (NP) ones with polynomial resources (in time, space, and energy). An abstract DMM with this power must satisfy a set of compatible mathematical constraints underlying its practical realization. We prove this by making a connection with the dynamical systems theory. This leads us to a set of physical constraints for poly-resource resolvability. Once the mathematical requirements have been assessed, we propose a practical scheme to solve the above class of problems based on the novel concept of self-organizing logic gates and circuits (SOLCs)...
February 2017: Chaos
https://www.readbyqxmd.com/read/28245103/optical-interference-free-surface-enhanced-raman-scattering-co-nanotags-for-logical-multiplex-detection-of-vascular-disease-related-biomarkers
#20
Tianxun Gong, Zi-Yao Hong, Ching-Hsiang Chen, Cheng-Yen Tsai, Lun-De Liao, Kien Voon Kong
Matrix metalloproteinases (MMPs), specifically MMP-2, MMP-7 and MMP-9, have been discovered to be linked to many forms of vascular diseases such as stroke, and their detection is crucial to facilitate clinical diagnosis. In this work, we prepared a class of optical interference-free SERS nanotags (CO-nanotags) that can be used for the purpose of multiplex sensing of different MMPs. Multiplex detection with absence of cross-talk was achieved by using CO-nanotags with individual tunable intrinsic Raman shifts of CO in 1800-2200 cm-1 region determined by the metal core and ligands of the metal carbonyl complex...
February 28, 2017: ACS Nano
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