Qianwen Zhang, Min Hui, Guo Chen, Huijing Huang, Shiyu Wang, Yanfei Ye, Yan Wang, Mengying Wang, Shuyuan Zhang, Lehao Huang, Fangjun Zhang, Zhiguo Liu
The instability of curcumin's structure and the toxic side effects of piperlongumine have limited their potential applications in cancer treatment. To overcome these challenges, we designed and synthesized a novel curcumin-piperlongumine hybrid molecule, 3-[( E )-4-hydroxy-3-methoxybenzylidene]-1-[( E )-3-(3,4,5-trimethoxyphenyl)acryloyl]piperidin-2-one (CP), using a molecular hybridization strategy. CP exhibited enhanced structural stability and safety compared with its parent compounds. Through in vitro and in vivo biological activity screenings, CP effectively inhibited cell proliferation, caused cell cycle arrest in the G2/M phase, and induced apoptosis...
March 22, 2024: Journal of Agricultural and Food Chemistry