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Cancer curcumin

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https://www.readbyqxmd.com/read/28077837/curcumin-inhibits-gastric-carcinoma-cell-growth-and-induces-apoptosis-by-suppressing-the-wnt-%C3%AE-catenin-signaling-pathway
#1
Ruzhen Zheng, Qinghua Deng, Yuehua Liu, Pengjun Zhao
BACKGROUND Curcumin has well-known, explicit biological anti-tumor properties. The Wnt/β-catenin signaling pathway plays a central role in tumor cell proliferation and curcumin can regulate the Wnt/b-catenin signaling pathway of several carcinomas. The aim of this study was to investigate the impact of curcumin on the Wnt/β-catenin signaling pathway in human gastric cancer cells. MATERIAL AND METHODS We used 3 gastric cancer cell lines: SNU-1, SNU-5, and AGS. Research methods used were MTT assay, flow cytometry, clonogenic assay, annexin V/PI method, Western blotting analysis, tumor formation assay, and in vivo in the TUNEL assay...
January 12, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28075466/co-delivery-of-doxorubicin-and-ph-sensitive-curcumin-prodrug-by-transferrin-targeted-nanoparticles-for-breast-cancer-treatment
#2
Tongxing Cui, Sihao Zhang, Hong Sun
The natural product curcumin and the chemotherapeutic agent doxorubicin have been used in the treatment of many cancers, including breast cancer. However, fast clearance and unspecific distribution in the body after intravenous injection are still challenges to be overcome by an ideal nano-sized drug delivery system in cancer treatment. In this study we design transferrin (Tf) decorated nanoparticles (NPs) to co-deliver CUR and DOX for breast cancer treatment. A pH-sensitive prodrug, transferrin-poly(ethylene glycol)-curcumin (Tf-PEG-CUR), was synthesized and used for the self‑assembling of NPs (Tf-PEG-CUR NPs)...
January 2, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28075008/promising-anti-tumor-properties-of-bisdemethoxycurcumin-a-naturally-occurring-curcumin-analogue
#3
REVIEW
Mahin Ramezani, Mahdi Hatamipour, Amirhosein Sahebkar
Curcuminoids are turmeric-extracted phytochemicals with documented chemopreventive and anti-tumor activities against several types of malignancies. Curcuminoids can modulate several molecular pathways and cellular targets involved in different stages of tumor initiation, growth and metastasis. Bisdemethoxycurcumin (BDMC) is a minor constituent (approximately 3%) of curcuminoids that has been shown to be more stable than the other two main curcuminoids i.e. curcumin and demthoxycurcumin. Recent studies have revealed that BDMC has anti-tumor effects exerted through a multimechanistic mode of action involving inhibition of cell proliferation, invasion and migration, metastasis and tumour growth, and induction of apoptotic death in cancer cells...
January 11, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28071969/curcumin-induces-apoptosis-in-human-leukemic-cell-lines-through-an-ifit2-dependent-pathway
#4
Yonglu Zhang, Yunyuan Kong, Shuyuan Liu, Lingbing Zeng, Lagen Wan, Zhanglin Zhang
Curcumin, the primary bioactive component isolated from turmeric, has been shown to possess variety of biological functions including anti-cancer activity. However, molecular mechanisms different cancer cells are various. In the present study, we demonstrated that curcumin induced G2/M cell cycle arrest and apoptosis by increasing the expression levels of cleaved caspase-3, cleaved PARP and decreasing the expression of BCL-2 in U937 human leukemic cells but not in K562 cells. We found some interferon induced genes, especially interferon-induced protein with tetratricopeptide repeats 2 (IFIT2), were significantly up-regulated when treated with curcumin in U937 cells by gene expression chip array, and further confirmed that the expression of IFIT2 was obviously higher in U937 than that in K562 cells by Western blot assay...
January 10, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28067673/a-novel-stat3-inhibitor-ho-3867-induces-cell-apoptosis-by-reactive-oxygen-species-dependent-endoplasmic-reticulum-stress-in-human-pancreatic-cancer-cells
#5
Yan Hu, Chengguang Zhao, Hailun Zheng, Kongqin Lu, Dengjian Shi, Zhiguo Liu, Xuanxuan Dai, Yi Zhang, Xiuhua Zhang, Wanle Hu, Guang Liang
Pancreatic cancer is the most commonly diagnosed malignancy among solid tumors and has shown an increasing trend year by year. Thus, there is an urgent need for the discovery of new anticancer drugs for the treatment of pancreatic cancer. In recent years, it has been reported that the compound HO-3867, a novel analog of the natural product curcumin, showed antitumor activity with low toxicity. However, the underlying mechanism of this compound's attack on cancer cells is not very clear. In the present study, it was found that HO-3867 showed good antitumor activity at the concentration of 2 μmol/l in PANC-1 and BXPC-3 cells...
January 6, 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/28067164/curcumin-and-lung-cancer-the-role-of-micrornas
#6
Diana Lelli, Claudio Pedone, Muhammed Majeed, Amirhosssein Sahebkar
BACKGROUND: Lung cancer is one of the most common types of cancer worldwide and is characterized by a poor prognosis, related both to late diagnosis and lack of effective treatments. In the last years, microRNAs (miRNAs) have been demonstrated to have an important role in tumor microenvironment and immune regulation. These RNAs can be categorized into tumor-suppressor genes, such as let-7 family and miR-34, and oncogenes such as miR-221 and miR-222. Curcumin is a bioactive polyphenol that is documented to have promising anti-cancer activity, and to be well tolerated in humans...
January 9, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28061797/natural-compounds-targeting-major-cell-signaling-pathways-a-novel-paradigm-for-osteosarcoma-therapy
#7
REVIEW
Pablo Angulo, Gaurav Kaushik, Dharmalingam Subramaniam, Prasad Dandawate, Kathleen Neville, Katherine Chastain, Shrikant Anant
Osteosarcoma is the most common primary bone cancer affecting children and adolescents worldwide. Despite an incidence of three cases per million annually, it accounts for an inordinate amount of morbidity and mortality. While the use of chemotherapy (cisplatin, doxorubicin, and methotrexate) in the last century initially resulted in marginal improvement in survival over surgery alone, survival has not improved further in the past four decades. Patients with metastatic osteosarcoma have an especially poor prognosis, with only 30% overall survival...
January 7, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28059418/highly-versatile-spion-encapsulated-plga-nanoparticles-as-photothermal-ablators-of-cancer-cells-and-as-multimodal-imaging-agents
#8
Balasubramanian Sivakumar, Ravindran Girija Aswathy, Rebeca Romero-Aburto, Trevor Mitcham, Keith A Mitchel, Yutaka Nagaoka, Richard R Bouchard, Pulickel M Ajayan, Toru Maekawa, Dasappan Nair Sakthikumar
We have designed versatile polymeric nanoparticles with cancer cell specific targeting capabilities via aptamer conjugation after the successful encapsulation of curcumin and superparamagnetic iron oxide nanoparticles (SPIONs) inside a PLGA nanocapsule. These targeted nanocomposites were selectively taken up by tumor cells, under in vitro conditions, demonstrating the effectiveness of the aptamer targeting mechanism. Moreover, the nanocomposite potentially functioned as efficient multiprobes for optical, magnetic resonance imaging (MRI) and photoacoustic imaging contrast agents in the field of cancer diagnostics...
January 6, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28058420/sensitized-zno-nanorod-assemblies-to-detect-heavy-metal-contaminated-phytomedicines-spectroscopic-and-simulation-studies
#9
Damayanti Bagchi, Tuhin Kumar Maji, Samim Sardar, Peter Lemmens, Chinmoy Bhattacharya, Debjani Karmakar, Samir Kumar Pal
The immense pharmacological relevance of the herbal medicine curcumin including anti-cancer and anti-Alzheimer effects, suggests it to be a superior alternative to synthesised drugs. The diverse functionalities with minimal side effects intensify the use of curcumin not only as a dietary supplement but also as a therapeutic agent. Besides all this effectiveness, some recent literature reported the presence of deleterious heavy metal contaminants from various sources in curcumin leading to potential health hazards...
January 6, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28053624/alkyl-cinnamates-induce-protein-kinase-c-translocation-and-anticancer-activity-against-breast-cancer-cells-through-induction-of-the-mitochondrial-pathway-of-apoptosis
#10
Suman Jyoti Deka, Narsimha Mamdi, Debasis Manna, Vishal Trivedi
PURPOSE: The protein kinase C (PKC) family of serine-threonine kinases plays an important role in cancer cell progression. Thus, molecules that target PKC have potential as anticancer agents. The current study aims to understand the treatment of breast cancer cells with alkyl cinnamates. We have also explored the mechanistic details of their anticancer action and the underlying molecular signaling. METHODS: 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was performed to measure the viability of MDAMB-231 breast cancer cells to assess the anticancer activity of these compounds...
December 2016: Journal of Breast Cancer
https://www.readbyqxmd.com/read/28053531/enhanced-photocytotoxicity-of-curcumin-delivered-by-solid-lipid-nanoparticles
#11
Shan Jiang, Rongrong Zhu, Xiaolie He, Jiao Wang, Mei Wang, Yechang Qian, Shilong Wang
Curcumin (Cur) is a promising photosensitizer that could be used in photodynamic therapy. However, its poor solubility and hydrolytic instability limit its clinical use. The aim of the present study was to encapsulate Cur into solid lipid nanoparticles (SLNs) in order to improve its therapeutic activity. The Cur-loaded SLNs (Cur-SLNs) were prepared using an emulsification and low-temperature solidification method. The functions of Cur and Cur-SLNs were studied on the non-small cell lung cancer A549 cells for photodynamic therapy...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28042086/curcumin-a-potentially-powerful-tool-to-reverse-cisplatin-induced-toxicity
#12
REVIEW
Ramin Rezaee, Amir Abbas Momtazi, Alireza Monemi, Amirhossein Sahebkar
Curcumin is a naturally occurring polyphenol isolated from Curcuma longa that has gained considerable interest over the last decades due to its beneficial effects for human health. Moreover, the usage of cisplatin, a platinum-based chemotherapeutic, is associated with several adverse effects affecting the quality of life of the patients. Also, cisplatin therapy is jeopardized by a great challenge of resistance which reduces the efficacy of this drug. In order to conquer these dark sides of cisplatin therapy, curcumin has been widely used to fight against cisplatin-resistant cancer cells and decrease its unwanted side effects (e...
December 29, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28038323/synthesis-and-biological-evaluation-of-curcumin-inspired-indole-analogues-as-tubulin-polymerization-inhibitors
#13
P V Sri Ramya, Srinivas Angapelly, Lalita Guntuku, Chander Singh Digwal, Bathini Nagendra Babu, V G M Naidu, Ahmed Kamal
In our endeavour towards the development of potent cytotoxic agents, a series of some new curcumin inspired indole analogues, in which indole and phenyl moieties are linked on either sides of 1,5-diaryl-1,4-pentadien-3-one system have been synthesized and characterized by spectral data. All the newly synthesized analogues were tested for their cytotoxic potential against a panel of eight cancer cell lines namely, lung (A549), breast (MDA-MB-231, BT549 and 4T1), prostate (PC-3, DU145), gastric (HGC-27) and cervical (HeLa)...
December 23, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28036082/retro-curcuminoids-as-mimics-of-dehydrozingerone-and-curcumin-synthesis-nmr-x-ray-and-cytotoxic-activity
#14
Marco A Obregón-Mendoza, María Mirian Estévez-Carmona, Simón Hernández-Ortega, Manuel Soriano-García, María Teresa Ramírez-Apan, Laura Orea, Hugo Pilotzi, Dino Gnecco, Julia Cassani, Raúl G Enríquez
Curcumin and its derivatives have been extensively studied for their remarkable medicinal properties, and their chemical synthesis has been an important step in the optimization of well-controlled laboratory production. A family of new compounds that mimic the structure of curcumin and curcuminoids, here named retro-curcuminoids (7-14), was synthesized and characterized using 1D ¹H- and (13)C-NMR, IR, and mass spectrometry; the X-ray structure of 7, 8, 9, 10, 12, 13, and 14 are reported here for the first time...
December 29, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28031196/nanotized-curcumin-and-miltefosine-a-potential-combination-for-the-treatment-of-experimental-visceral-leishmaniasis
#15
Brajendra Tiwari, Richa Pahuja, Pradeep Kumar, Srikanth Kumar Rath, Kailash Chand Gupta, Neena Goyal
Leishmaniasis chemotherapy remains very challenging due to high cost of the drug and its associated toxicity and drug resistance which develops over a period of time. Now-a-days combination therapies (CT) are in use for many diseases like cancer and malaria being more effective and affordable than monotherapy. CT is believed to represent a new explorable strategy for leishmaniasis, a neglected tropical disease caused by obligate intracellular parasite Leishmania In the present work, we have adopted a rational approach, to investigate the effect of combination of traditional Indian medicine (Ayurveda), a natural product curcumin and miltefosine, the only oral drug for visceral leishmaniasis (VL) using Leishmania (Leishmania) donovani/hamster model...
December 28, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28029125/ameliorative-effect-of-curcumin-encapsulated-hyaluronic-acid-pla-nanoparticles-on-thioacetamide-induced-murine-hepatic-fibrosis
#16
Yu-Nong Chen, Shih-Lan Hsu, Ming-Yuan Liao, Yi-Ting Liu, Chien-Hung Lai, Ji-Feng Chen, Mai-Huong Thi Nguyen, Yung-Hsiang Su, Shang-Ting Chen, Li-Chen Wu
In this study, we developed curcumin-encapsulated hyaluronic acid-polylactide nanoparticles (CEHPNPs) to be used for liver fibrosis amelioration. CD44, the hyaluronic acid (HA) receptor, is upregulated on the surface of cancer cells and on activated hepatic stellate cells (aHSCs) rather than normal cells. CEHPNPs could bind to CD44 and be internalized effectively through endocytosis to release curcumin, a poor water-soluble liver protective agent. Thus, CEHPNPs were potentially not only improving drug efficiency, but also targeting aHSCs...
December 24, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28027539/construction-and-comparison-of-different-nanocarriers-for-co-delivery-of-cisplatin-and-curcumin-a-synergistic-combination-nanotherapy-for-cervical-cancer
#17
Changming Li, Xiangcheng Ge, Liguo Wang
PURPOSE: Co-delivery of two or more drugs into the same cancer cells or tissues in the same nanocarriers provides a new paradigm in cancer treatment. In this study, two kinds of nanocarriers: lipid-polymer hybrid nanoparticles (LPNs) and polymeric nanoparticles (PNPs) were constructed and compared for co-delivery of cisplatin (DDP) and curcumin (CUR). METHODS: DDP and CUR loaded LPNs (D/C/LPNs) and PNPs (D/C/PNPs) were prepared. Two kinds of nanocarriers were characterized in terms of particle size, zeta potential, drug encapsulation efficiency (EE), and drug release...
December 24, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28024945/mc37-a-new-mono-carbonyl-curcumin-analog-induces-g2-m-cell-cycle-arrest-and-mitochondria-mediated-apoptosis-in-human-colorectal-cancer-cells
#18
Baoxia Liang, Ziyi Liu, Yingnan Cao, Cuige Zhu, Yinglin Zuo, Lei Huang, Gesi Wen, Nana Shang, Yu Chen, Xin Yue, Jun Du, Baojian Li, Binhua Zhou, Xianzhang Bu
(E)-1-(3'-fluoro-[1,1'-biphenyl-3-yl)-3-(3-hydroxy-4-methoxyphenyl)prop-2-en-1-one) (MC37), a novel mono-carbonyl curcumin analog, was previously synthesized in our laboratory as a nuclear factor kappa B (NF-κB) inhibitor with excellent cytotoxicity against several cancer cell lines. In this study, our further investigations showed that the potent growth inhibitory activity of MC37 in human colorectal cancer cells was associated with the arrest of cell cycle progression and the induction of apoptosis. As a multi-targeted agent, MC37 inhibited the intracellular microtubule assembly, altered the expression of cyclin-dependent kinase 1 (CDK1), and ultimately induced G2/M cell cycle arrest...
December 23, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28024125/recent-progress-on-curcumin-based-therapeutics-a-patent-review-2012-2016-part-i-curcumin
#19
Rita Maria Concettaa Di Martino, Barbara Luppi, Alessandraa Bisi, Silviaa Gobbi, Angela Rampa, Angela Abruzzo, Federica Bellutia
curcumin is the main bioactive component contained in Curcuma Longa, largely employed in traditional medicine. Recently, beneficial properties, useful for prevention and treatment of several disorders, have been discovered for this compound. Peculiar structural feature is an α,β-unsaturated carbonyl system essential for establishing contacts with critical cysteine residues of several targets. This distinctive mechanism of action imparts to the molecule the ability to affect a large number of targets, accounting for its pleiotropic behaviour and definition of "privileged structure"...
December 26, 2016: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/28011386/curcumin-inhibits-growth-potential-by-g1-cell-cycle-arrest-and-induces-apoptosis-in-p53-mutated-colo-320dm-human-colon-adenocarcinoma-cells
#20
Jade Dhananjay Dasiram, Ramamoorthi Ganesan, Janani Kannan, Venkatesan Kotteeswaran, Nageswaran Sivalingam
Curcumin, a natural polyphenolic compound and it is isolated from the rhizome of Curcuma longa, have been reported to possess anticancer effect against stage I and II colon cancer. However, the effect of curcumin on colon cancer at Dukes' type C metastatic stage III remains still unclear. In the present study, we have investigated the anticancer effects of curcumin on p53 mutated COLO 320DM human colon adenocarcinoma cells derived from Dukes' type C metastatic stage. The cellular viability and proliferation were assessed by trypan blue exclusion assay and MTT assay, respectively...
December 20, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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