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Cancer curcumin

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https://www.readbyqxmd.com/read/29923222/effects-of-curcumin-on-nf-%C3%AE%C2%BAb-ap-1-and-wnt-%C3%AE-catenin-signaling-pathway-in-hepatitis-b-virus-infection
#1
AmirReza Hesari, Faezeh Ghasemi, Reza Salarinia, Hamed Biglari, Agheel Tabar Molla Hassan, Vali Abdoli, Hamed Mirzaei
Curcumin is a yellow-orange powder derived from the Curcuma longa plant. Curcumin has been used extensively in traditional medicine for centuries. This component is non-toxic and shown different therapeutic properties such as anti-inflammatory, anti-cancer, antiviral, anti-bacterial, anti-fungal, anti-parasites, and anti-oxidant. Hepatitis B virus (HBV) is a small DNA member of the genus Orthohepadnavirus (Hepadnaviridae family) which is a highly contagious blood-borne viral pathogen. HBV infection is a major public health problem with 2 billion people infected throughout the world and 350 million suffering from chronic HBV infection...
June 19, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29911313/curcumin-prevents-the-bile-reflux-induced-nf-%C3%AE%C2%BAb-related-mrna-oncogenic-phenotype-in-human-hypopharyngeal-cells
#2
Dimitra P Vageli, Sotirios G Doukas, Todd Spock, Clarence T Sasaki
The presence of bile is not an uncommon finding in acidic oesophageal and extra-oesophageal refluxate, possibly affecting the hypopharyngeal mucosa and leading to neoplastic events. We recently demonstrated that acidic bile (pH ≤ 4.0) can induce NF-κB activation and oncogenic mRNA phenotype in normal hypopharyngeal cells and generate premalignant changes in treated hypopharyngeal mucosa. We hypothesize that curcumin, a dietary inhibitor of NF-κB, may effectively inhibit the acidic bile-induced cancer-related mRNA phenotype, in treated human hypopharyngeal primary cells (HHPC), supporting its potential preventive use in vivo...
June 17, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29908009/amphiphilic-y-shaped-miktoarm-star-copolymer-for-anti-cancer-hydrophobic-and-hydrophilic-drugs-co-delivery-synthesis-characterization-in-vitro-and-in-vivo-biocompatibility-study
#3
Mozhgan Aghajanzadeh, Mostafa Zamani, Hamid Rashidzadeh, Kobra Rostamizadeh, Ali Sharafi, Hossein Danafar
In this project, a core-shell Polymersome based on miktoarm star-copolymer: methoxy Poly Ethylene Glycol-Lysine-(Poly Caprolactone)2 (PEG-Lys-PCL2 ) was synthesized by a new method as controlled targeted drug delivery systems for co-delivery of the chemotherapeutic methotrexate (MTX) and curcumin (CUR). Some properties of these nano carriers (NCs) such as surface morphology, structure, surface charge, stability and biocompatibility were evaluated by Proton nuclear magnetic resonance (1 HNMR), dynamic scanning colorimetry (DSC), Fourier-transform infrared spectroscopy (FT-IR), Dynamic light scattering (DLS), atomic force microscopy (AFM), Critical aggregation concentration (CAC), hemolysis test, MTT assay and lethal dose 50 (LD50)...
June 16, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29902578/the-impact-of-the-effectiveness-of-gata3-as-a-prognostic-factor-in-breast-cancer
#4
Fararjeh-Salah Abdul Fattah, Shih-Hsin Tu, Li-Ching Chen, Yun-Ru Liu, Yen-Kuang Lin, Hang-Lung Chang, Hui-Wen Chang, Chih-Hsiung Wu, Wendy-Hwang Verslues, Yuan-Soon Ho
The transcription factor GATA3 plays a significant role in mammary gland development and differentiation. We analyzed expression of GATA3 in breast cancer (BC) cell lines and clinical specimens from BC patients in Taiwan. Semi-quantitative reverse transcriptase (RT)-polymerase chain reaction (PCR), quantitative real-time PCR carried out to determine the mRNA level of GATA3 from 241 pairs of matched tumor and adjacent normal tissues from anonymous female donors. GATA3 immunohistochemistry (IHC) staining and H-score were performed (n=25)...
June 11, 2018: Human Pathology
https://www.readbyqxmd.com/read/29901626/curcumin-induces-endoplasmic-reticulum-stress-associated-apoptosis-in-human-papillary-thyroid-carcinoma-bcpap-cells-via-disruption-of-intracellular-calcium-homeostasis
#5
Li Zhang, Xian Cheng, Shichen Xu, Jiandong Bao, Huixin Yu
BACKGROUND: Thyroid cancer is the most common endocrine tumor. Our previous studies have demonstrated that curcumin can induce apoptosis in human papillary thyroid carcinoma BCPAP cells. However, the underlined mechanism has not been clearly elucidated. Endoplasmic reticulum (ER) is a major organelle for synthesis, maturation, and folding proteins as well as a large store for Ca. Overcoming chronically activated ER stress by triggering pro-apoptotic pathways of the unfolded protein response (UPR) is a novel strategy for cancer therapeutics...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29901164/curcumin-inhibits-liver-cancer-by-inhibiting-damp-molecule-hsp70-and-tlr4-signaling
#6
Biqiong Ren, Shudi Luo, Xuefei Tian, Zhichao Jiang, Guoying Zou, Fei Xu, Tieqiu Yin, Yiran Huang, Junlong Liu
Curcumin has been revealed to inhibit liver cancer, however, no studies have reported that the mechanism of curcumin's action on liver cancer is related to damage-associated molecular pattern (DAMP) molecules heat shock protein 70 (HSP70) and the toll-like receptor 4 (TLR4) signaling. This study aimed to investigate whether the activation of TLR4 signaling by HSP70 could be inhibited by curcumin, thus investigating the possible mechanism of curcumin in the inhibition of liver cancer. Western blotting was used to evaluate the expression of the HSP70 and TLR4 in HepG2 cells and ELISA was used to detect the concentration of HSP70 in cell culture medium...
June 11, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29901131/sequence%C3%A2-dependent-effect-of-sorafenib-in-combination-with-natural-phenolic-compounds-on-hepatic-cancer-cells-and-the-possible-mechanism-of-action
#7
Abdulmajeed A Bahman, Mohamed Salah I Abaza, Sarah I Khoushiash, Rajaa J Al-Attiyah
Sorafenib (Nexavar, BAY43‑9006 or Sora) is the first molecular targeted agent that has exhibited significant therapeutic benefits in advanced hepatocellular carcinoma (HCC). However, not all HCC patients respond well to Sora and novel therapeutic strategies to optimize the efficacy of Sora are urgently required. Plant‑based drugs have received increasing attention owing to their excellent chemotherapeutic and chemopreventive activities; they are also well tolerated, non‑toxic, easily available and inexpensive...
June 8, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29901071/curcumin-inhibits-cell-proliferation-and-motility-via-suppression-of-trop2-in-bladder-cancer-cells
#8
Lianhua Zhang, Guoliang Yang, Ruiyun Zhang, Liang Dong, Haige Chen, Juanjie Bo, Wei Xue, Yiran Huang
Bladder cancer (BC) has become a serious health prob-lem and represents the second most commonly diagnosed urological tumor. Curcumin is a principal active natural component of turmeric and has long been used in Asia as a traditional herbal medicine. Curcumin suppresses cell growth in various types of cancer, including BC, by regulating numerous molecular signaling pathways. The human trophoblast cell surface antigen 2 (Trop2) belongs to the tumor-associated calcium signal transducer gene family. Trop2 has been described as a cancer driver and is deregulated in various types of cancer...
May 30, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29899871/folic-acid-conjugated-mesoporous-silica-particles-as-nanocarriers-of-natural-prodrugs-for-cancer-targeting-and-antioxidant-action
#9
Khaled AbouAitah, Anna Swiderska-Sroda, Ahmed A Farghali, Jacek Wojnarowicz, Agata Stefanek, Stanislaw Gierlotka, Agnieszka Opalinska, Abdou K Allayeh, Tomasz Ciach, Witold Lojkowski
Naturally derived prodrugs have a wide range of pharmacological activities, including anticancer, antioxidant, and antiviral effects. However, significant barriers inhibit their use in medicine, e.g. their hydrophobicity. In this comprehensive study, we investigated simple and effective nanoformulations consisting of amine-functionalized and conjugated with folic acid (FA) mesoporous silica nanoparticles (MSNs). Two types of MSNs were studied: KCC- 1, with mean size 324 nm and mean pore diameter 3.4 nm, and MCM - 41, with mean size 197 and pore diameter 2 nm...
May 29, 2018: Oncotarget
https://www.readbyqxmd.com/read/29894862/phytochemicals-inhibit-the-immunosuppressive-functions-of-myeloid-derived-suppressor-cells-mdsc-impact-on-cancer-and-age-related-chronic-inflammatory-disorders
#10
REVIEW
Antero Salminen, Kai Kaarniranta, Anu Kauppinen
Traditional herbal medicine has provided natural remedies against cancers and many age-related inflammatory diseases for thousands of years. Modern drug discovery techniques have revealed several active ingredients and their medicinal targets have been characterized. Concurrently, there has been great progress in understanding the pathological mechanisms underpinning cancers and inflammatory diseases. These studies have demonstrated that immature myeloid-derived suppressor cells (MDSCs) have a crucial role in the immune escape of cancer cells thus promoting tumor growth...
June 8, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29890691/design-synthesis-anticancer-evaluation-and-docking-studies-of-novel-heterocyclic-derivatives-obtained-via-reactions-involving-curcumin
#11
Rita M Borik, Nagwa M Fawzy, Sherifa M Abu-Bakr, Magdy S Aly
Curcumin, a widely utilized flavor and coloring agent in food, has been shown to demonstrate powerful antioxidant, antitumor promoting and anti-inflammatory properties in vitro and in vivo. In the present work, synthesis of new heterocyclic derivatives based on Curcumin was studied. Compound 3 was synthesized via the reaction of furochromone carbaldehyde ( 1 ) with Curcumin ( 2 ) using pipredine as catalyst. Also, novel, 4,9-dimethoxy-5 H -furo [3, 2- g ] chromen-5-one derivatives 4a ⁻ d , 6a ⁻ d , 7 , 8a ⁻ d , 9 and 10 were synthesized by the reactions of furochromone carbaldehyde ( 1 ) with different reagents (namely: appropriate amine 3a ⁻ d , appropriate hydrazine 5a ⁻ d , hydroxylamine hydrochloride, urea/thiourea, malononitrile, malononitrile with hydrazine hydrate)...
June 8, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29885528/glutathione-detonated-and-ph-responsive-nano-clusters-of-au-nanorods-with-a-high-dose-of-dox-for-treatment-of-multidrug-resistant-cancer
#12
Yun Wang, Feihu Wang, Ying Liu, Shaohui Xu, Yuanyuan Shen, Nianping Feng, Shengrong Guo
Effects of nanosized drug delivery systems on cancer are often compromised due to their low drug loadings, premature drug release and multi-drug resistance (MDR). Herein, we reported a glutathione detonated and pH responsive nano-cluster of Au nanorods (AuNRs) with chemotherapeutic doxorubicin (DOX) and pre-chemosensitizer polycurcumin to treat MCF-7/ADR cells. The nano-cluster was prepared by self-assembling of AuNRs conjugated with DOX and amphiphilic poly(curcumin-co-dithiodipropionic acid)-b-biotinylated poly(ethylene glycol) via an emulsion/solvent evaporation technique, termed AuNR Cluster...
June 6, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29882920/t59-a-new-compound-reconstructed-from-curcumin-induces-cell-apoptosis-through-reactive-oxygen-species-activation-in-human-lung-cancer-cells
#13
Zhendong Zhao, Yanjun Yang, Weihai Liu, Ziqian Li
Curcumin is acknowledged for its antioxidant, anti-inflammatory, anti-cancer, and wound-healing properties. However, the biological activity and the molecular mechanisms of T59, which is a new derivative of curcumin, are not fully understood. The present study was aimed to determine the cytoxicity role of T59 in human lung cancer and the molecular mechanisms. Cytotoxicity and cell apoptosis effects induced by T59 were determined by MTT, AO staining, Annexin V, and JC-1. Compared with curcumin, T59 exerted more effective cytotoxicity and cell apoptosis effects in A549 and H1975...
May 24, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29881683/inhalation-treatment-of-primary-lung-cancer-using-liposomal-curcumin-dry-powder-inhalers
#14
Tongtong Zhang, Yanming Chen, Yuanyuan Ge, Yuzhen Hu, Miao Li, Yiguang Jin
Lung cancer is the leading cause of cancer-related deaths. Traditional chemotherapy causes serious toxicity due to the wide bodily distribution of these drugs. Curcumin is a potential anticancer agent but its low water solubility, poor bioavailability and rapid metabolism significantly limits clinical applications. Here we developed a liposomal curcumin dry powder inhaler (LCD) for inhalation treatment of primary lung cancer. LCDs were obtained from curcumin liposomes after freeze-drying. The LCDs had a mass mean aerodynamic diameter of 5...
May 2018: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/29881406/co-delivery-of-sulforaphane-and-curcumin-with-pegylated-iron-oxide-gold-core-shell-nanoparticles-for-delivery-to-breast-cancer-cell-line
#15
Hossein Danafar, Ali Sharafi, Shaghayegh Kheiri, Hamidreza Kheiri Manjili
Co-delivery approach has been recommended to reduce the amount of each drug and to achieve the synergistic effect for cancer treatment. Curcumin (CUR) and sulforaphane (SF) have antitumor effects, but their application is limited because of their low water solubility and poor oral bioavailability. To improve the bioavailability and solubility of SF and CUR, we performed an innovative co-delivery of them with PEGylated gold coated Fe3 O4 magnetic nanoparticles (PEGylated Fe3 O4 @Au NPs) to endorse SF and CUR maintenance as an effective and promising antitumor drugs...
2018: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29878887/case-report-of-a-human-papillomavirus-infection-treated-with-green-tea-extract-and-curcumin-vaginal-compounded-medications
#16
Kelechi E Agbi, Sara Hover, Maria Carvalho
The human papillomaviruses are the most common sexually transmitted infections in the U.S., and the majority of these infections are cleared by the body's natural immune system without causing any harm. The high-risk human papillomavirus types, however, cause approximately 5 percent of all cancers worldwide. A prophylactic vaccine was recently introduced, but there is still no commercially available treatment that targets active infections. This case study discusses a 48-year-old female who was diagnosed as human papillomavirus positive (+) following a routine gynecological examination...
May 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29877694/synthesis-of-a-block-copolymer-exhibiting-cell-responsive-phytochemical-release-for-cancer-therapy
#17
Nagarajan Padmavathy, Lopamudra Das Ghosh, Sai Rama Krishna Meka, Kaushik Chatterjee
Phytochemicals constitute a promising class of therapeutics for the treatment of various diseases, but their delivery poses significant challenges. In this work, a nanoscale polyactive emulsion was designed for smart, cell-responsive delivery of a curcumin prodrug (curcumin dicarboxylate, CDA) that was chemically conjugated to enzymatically labile oligo-peptides with polycaprolactone (PCL) as the carrier. Matrix metalloproteinase (MMP) sensitive (PLGLYAL) and/or non-sensitive (GPYYPLG) peptides were used as spacers for conjugating CDA and PCL...
June 7, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29872613/synthesis-of-novel-aza-aromatic-curcuminoids-with-improved-biological-activities-towards-various-cancer-cell-lines
#18
Atiruj Theppawong, Tim Van de Walle, Charlotte Grootaert, Margot Bultinck, Tom Desmet, John Van Camp, Matthias D'hooghe
Curcumin, a natural compound extracted from the rhizomes of Curcuma longa , displays pronounced anticancer properties but lacks good bioavailability and stability. In a previous study, we initiated structure modification of the curcumin scaffold by imination of the labile β-diketone moiety to produce novel β-enaminone derivatives. These compounds showed promising properties for elaborate follow-up studies. In this work, we focused on another class of nitrogen-containing curcuminoids with a similar objective: to address the bioavailability and stability issues and to improve the biological activity of curcumin...
May 2018: ChemistryOpen
https://www.readbyqxmd.com/read/29870054/pharmacokinetics-and-pharmacodynamics-of-curcumin-in-regulating-anti-inflammatory-and-epigenetic-gene-expression
#19
Sarandeep S S Boyanapalli, Ying Huang, Zhengyuan Su, David Cheng, Chengyue Zhang, Yue Guo, Rohit Rao, Ioannis P Androulakis, Ah-Ng Kong
Chronic inflammation is a key driver of cancer development. Nitrite levels, which are regulated by inducible nitric oxide synthase (iNOS), play a critical role in inflammation. While the anti-oxidant and anti-inflammatory effects of curcumin, a natural product present in the roots of Curcuma longa have been widely studied, the acute pharmacokinetics (PK) and pharmacodynamics (PD) of curcumin in suppressing pro-inflammatory markers and epigenetic modulators remain unclear. In this study, we evaluated the PK and PD of curcumin-induced suppression of lipopolysaccharide (LPS)-mediated inflammation in rat lymphocytes...
June 5, 2018: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/29869524/ratiometric-delivery-of-two-therapeutic-candidates-with-inherently-dissimilar-physicochemical-property-through-ph-sensitive-core-shell-nanoparticles-targeting-the-heterogeneous-tumor-cells-of-glioma
#20
He-Lin Xu, Zi-Liang Fan, De-Li ZhuGe, Meng-Qi Tong, Bi-Xin Shen, Meng-Ting Lin, Qun-Yan Zhu, Bing-Hui Jin, Yasin Sohawon, Qing Yao, Ying-Zheng Zhao
Currently, combination drug therapy is one of the most effective approaches to glioma treatment. However, due to the inherent dissimilar pharmacokinetics of individual drugs and blood brain barriers, it was difficult for the concomitant drugs to simultaneously be delivered to glioma in an optimal dose ratio manner. Herein, a cationic micellar core (Cur-M) was first prepared from d-α-tocopherol-grafted-ε-polylysine polymer to encapsulate the hydrophobic curcumin, followed by dopamine-modified-poly-γ-glutamic acid polymer further deposited on its surface as a anion shell through pH-sensitive linkage to encapsulate the hydrophilic doxorubicin (DOX) hydrochloride...
November 2018: Drug Delivery
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