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https://www.readbyqxmd.com/read/28822638/modified-anterolateral-portals-in-elbow-arthroscopy-a-cadaveric-study-on-safety
#1
Stephen Thon, Peter Gold, Lane Rush, Michael J O'Brien, Felix H Savoie
PURPOSE: To evaluate the proximity to the radial nerve on cadaveric specimens of 2 modified anterolateral portals used for elbow arthroscopy. METHODS: Ten fresh cadaveric elbow specimens were prepared. Four-millimeter Steinman pins were inserted into 3 anterolateral portal sites in relation to the lateral epicondyle: (1) the standard distal anterolateral portal, (2) a modified direct anterolateral portal, and (3) a modified proximal anterolateral portal. These were defined as follows: direct portals 2 cm directly anterior to the lateral epicondyle, and proximal portals 2 cm proximal and 2 cm directly anterior to the lateral epicondyle...
August 16, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28817495/nursing-management-of-the-patient-undergoing-focused-ultrasound-a-new-treatment-option-for-essential-tremor
#2
Katherine Dale Shaw, Amy Sue Johnston, Shelly Rush-Evans, Susan Prather, Kathy Maynard
Essential tremor (ET) is among the most common neurological movement disorders that causes postural or action tremors, with an estimated prevalence nationwide of less than 3% of the population. The incidence of ET increases with age but often affects younger adults and has a familial trait association. Depending on disease progression, ET can cause significant limitations for individuals, in many cases, significantly limiting their ability to perform activities of daily living and occupational responsibilities...
August 16, 2017: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
https://www.readbyqxmd.com/read/28817190/a-phase-1-and-2-study-of-filanesib-alone-and-in-combination-with-low-dose-dexamethasone-in-relapsed-refractory-multiple-myeloma
#3
Jatin J Shah, Jonathan L Kaufman, Jeffrey A Zonder, Adam D Cohen, William I Bensinger, Brandi W Hilder, Selena A Rush, Duncan H Walker, Brian J Tunquist, Kevin S Litwiler, Mieke Ptaszynski, Robert Z Orlowski, Sagar Lonial
BACKGROUND: Filanesib (ARRY-520) is a highly selective inhibitor of kinesin spindle protein, which has demonstrated preclinical antimyeloma activity. METHODS: This open-label Phase 1/2 study determined the maximum tolerated dose of Filanesib administered on Days 1 and 2 of 14-Day Cycles in patients with multiple myeloma (MM) and included expansion cohorts with and without dexamethasone (40 mg/week). Patients in the dose-escalation (N = 31) and Phase 2 single-agent (N = 32) cohorts had received prior bortezomib as well as prior thalidomide and/or lenalidomide...
August 17, 2017: Cancer
https://www.readbyqxmd.com/read/28816422/dolichol-kinase-deficiency-dolk-cdg-two-new-cases-and-expansion-of-phenotype
#4
Eric T Rush, Craig V Baker, William B Rizzo
Congenital disorders of glycosylation (CDGs) are a group of genetic diseases caused by mutations in genes that are necessary for the addition of oligosaccharides to acceptor proteins or lipids. An early step in this process requires dolichol kinase (DK) to catalyze the formation of dolichyl phosphate, which acts as a membrane anchor for initial attachment of sugar residues that are subsequently built up to oligosaccharides and transferred to acceptor proteins and lipids for further processing. Biallelic mutations in DOLK, the gene for DK, result in human in a CDG with variable symptoms, ranging from nonsyndromic dilated cardiomypopathy to severe multiorgan involvement...
September 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28815817/wrong-patient-incidents-during-medication-administrations
#5
Marja Härkänen, Maijaterttu Tiainen, Kaisa Haatainen
AIMS: The aims of this study are to describe the factors pertaining to medication being administered to the wrong patient and to describe how patient identification is mentioned in wrong-patient incident reports. BACKGROUND: Although patient identification has been given high priority to improve patient safety, patient misidentifications occur, and wrong-patient incidents are common. DESIGN: A descriptive content analysis. METHODS: Incident reports related to medication administration (n=1012) were collected from two hospitals in Finland between January 1st, 2013, and December 31st, 2014...
August 17, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28810211/how-local-health-departments-work-towards-health-equity
#6
Rebeccah Sokol, Beth Moracco, Sharon Nelson, Jill Rushing, Tish Singletary, Karen Stanley, Anna Stein
BACKGROUND: Health inequities are exacerbated when health promotion programs and resources do not reach selected populations. Local health departments (LHDs)(1) have the potential to address health equity via engaging priority populations in their work. However, we do not have an understanding of what local agencies are doing on this front. METHODS: In the summer of 2016, we collaborated with informants from thirteen LHDs across North Carolina. Via semi-structured interviews, the research team asked informants about their LHD's understanding of health equity and engaging priority populations in program planning, implementation, and evaluation...
August 5, 2017: Evaluation and Program Planning
https://www.readbyqxmd.com/read/28810089/the-healing-arts-through-poetry-a-rush-to-undertake-a-fool-s-errand
#7
Henry Travers
No abstract text is available yet for this article.
February 2017: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/28803710/intrathecal-2-hydroxypropyl-%C3%AE-cyclodextrin-decreases-neurological-disease-progression-in-niemann-pick-disease-type-c1-a-non-randomised-open-label-phase-1-2-trial
#8
Daniel S Ory, Elizabeth A Ottinger, Nicole Yanjanin Farhat, Kelly A King, Xuntian Jiang, Lisa Weissfeld, Elizabeth Berry-Kravis, Cristin D Davidson, Simona Bianconi, Lee Ann Keener, Ravichandran Rao, Ariane Soldatos, Rohini Sidhu, Kimberly A Walters, Xin Xu, Audrey Thurm, Beth Solomon, William J Pavan, Bernardus N Machielse, Mark Kao, Steven A Silber, John C McKew, Carmen C Brewer, Charles H Vite, Steven U Walkley, Christopher P Austin, Forbes D Porter
BACKGROUND: Niemann-Pick disease, type C1 (NPC1) is a lysosomal storage disorder characterised by progressive neurodegeneration. In preclinical testing, 2-hydroxypropyl-β-cyclodextrins (HPβCD) significantly delayed cerebellar Purkinje cell loss, slowed progression of neurological manifestations, and increased lifespan in mouse and cat models of NPC1. The aim of this study was to assess the safety and efficacy of lumbar intrathecal HPβCD. METHODS: In this open-label, dose-escalation phase 1-2a study, we gave monthly intrathecal HPβCD to participants with NPC1 with neurological manifestation at the National Institutes of Health (NIH), Bethesda, MD, USA...
August 10, 2017: Lancet
https://www.readbyqxmd.com/read/28796862/out-of-pocket-costs-financial-distress-and-underinsurance-in-cancer-care
#9
Fumiko Chino, Jeffrey M Peppercorn, Christel Rushing, Arif H Kamal, Ivy Altomare, Greg Samsa, S Yousuf Zafar
No abstract text is available yet for this article.
August 10, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28793834/a-preliminary-examination-of-the-role-of-psychotherapist-fidelity-on-outcomes-of-cognitive-processing-therapy-during-an-rct-for-military-sexual-trauma-related-ptsd
#10
Nicholas Holder, Ryan Holliday, Rush Williams, Kacy Mullen, Alina Surís
While cognitive processing therapy (CPT) is an effective evidence-based treatment for many veterans with military-related post-traumatic stress disorder (PTSD), not all veterans experience therapeutic benefit. To account for the discrepancy in outcomes, researchers have investigated patient- and research design-related factors; however, therapist factors (e.g. fidelity) have received less attention. The present study is a preliminary examination of the effect of psychotherapists' fidelity during CPT on clinical outcomes during a randomized clinical trial (RCT) for military sexual trauma-related PTSD...
August 10, 2017: Cognitive Behaviour Therapy
https://www.readbyqxmd.com/read/28792305/be-aware-of-extremism
#11
Sarah Hammerton
It's as simple as picking up the phone and making a referral. For those who have done Prevent training, it's about recognising the red flags; the same red flags as recognising vulnerabilities in safeguarding and making a referral there. I get that we are all busy and rushed off our feet, honestly I do. But it's not about spotting a bomb, it's about spotting a vulnerability early. We do it every day.
August 9, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28780896/addressing-the-unmet-needs-of-current-antidepressants-does-neuroscience-help-or-hinder-clinical-psychopharmacology-research
#12
Joseph F Goldberg, A John Rush
No abstract text is available yet for this article.
August 7, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28772060/methanotroph-derived-bacteriohopanepolyol-bhp-signatures-as-a-function-of-temperature-related-growth-survival-cell-death-and-preservation-in-the-geological-record
#13
Kate A Osborne, Neil D Gray, Angela Sherry, Peter Leary, Obioma Mejeha, Juliane Bischoff, Darci Rush, Frances R Sidgwick, Daniel Birgel, Marina G Kalyuzhnaya, Helen M Talbot
Interpretation of bacteriohopanepolyol (BHP) biomarkers tracing microbiological processes in modern and ancient sediments relies on understanding environmental controls of production and preservation. BHPs from methanotrophs (35-aminoBHPs) were studied in methane-amended aerobic river-sediment incubations at different temperatures. It was found that: 1. With increasing temperature (4-40°C) a tenfold increase in aminopentol (associated with Crenothrix and Methylobacter spp. growth) occurred with only marginal increases in aminotriol and aminotetrol; 2...
August 3, 2017: Environmental Microbiology Reports
https://www.readbyqxmd.com/read/28766504/the-association-between-serum-tsh-levels-and-bmi-percentiles-in-children-with-primary-hypothyroidism-that-are-chemically-euthyroid-on-levothyroxine-replacement
#14
Asma Shaoba, Sanjib Basu, Stelios Mantis, Carla Minutti
OBJECTIVE: To determine if there is a association between TSH levels and BMI percentiles in children with primary hypothyroidism who are chemically euthyroid and on treatment with levothyroxine. METHODS: Retrospective cross-sectional study, consisting of review of medical records from RUSH Medical Center and Stroger Hospital, Chicago, IL, U.SA. Children (seen in clinic from 2008-2014) with primary hypothyroidism who were chemically euthyroid and on treatment with levothyroxine for at least 6 months were included in the study...
August 2, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28763921/-a-survey-on-high-risk-behaviors-and-hiv-infection-among-men-having-sex-with-men-who-use-drugs-in-tianjin-in-2016
#15
D Shan, D Wu, L Liu, H Liu, W Y Yin, M H Yu, J Yang, J P Sun, D P Zhang
Objective: To analyze the characteristics of high risk sexual behaviors and HIV infectious status among men who have sex with men (MSM) who use drugs in Tianjin in 2016. Methods: From April to December in 2016, MSM who use drugs in Tianjin were targetedly and extensively mobilized to receive testing by snowball sampling method. The inclusion criteria were as follows: men aged 18 years old and above; have had oral or anal sex with men in the last 6 months; have had drug abuse history in the last 6 months, including the use of rush poppers, 5-Methoxy-diisopropyltryptamine (5-MeO-DiPT), and Methamphetamine Synthesis substances; and with no mental disorder or mental deficiency...
August 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28761931/unc5c-variants-are-associated-with-cerebral-amyloid-angiopathy
#16
Hyun-Sik Yang, Charles C White, Lori B Chibnik, Hans-Ulrich Klein, Julie A Schneider, David A Bennett, Philip L De Jager
OBJECTIVE: To determine whether common genetic variants in UNC5C, a recently identified late-onset Alzheimer disease (LOAD) dementia susceptibility gene, are associated with AD susceptibility or AD-related clinical/pathologic phenotypes. METHODS: We used data from deceased individuals of European descent who participated in the Religious Orders Study or the Rush Memory and Aging Project (n = 1,288). We examined whether there were associations between single nucleotide polymorphisms (SNPs) within ±100 kb of the UNC5C gene and a diagnosis of AD dementia, global cognitive decline, a pathologic diagnosis of AD, β-amyloid load, neuritic plaque count, diffuse plaque count, paired helical filament tau density, neurofibrillary tangle count, and cerebral amyloid angiopathy (CAA) score...
August 2017: Neurology. Genetics
https://www.readbyqxmd.com/read/28759366/calling-time-on-the-immunotherapy-gold-rush
#17
EDITORIAL
The Lancet Oncology
No abstract text is available yet for this article.
August 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28758054/instance-search-retrospective-with-focus-on-trecvid
#18
George Awad, Wessel Kraaij, Paul Over, Shin'ichi Satoh
This paper presents an overview of the Video Instance Search benchmark which was run over a period of 6 years (2010-2015) as part of the TREC Video Retrieval (TRECVID) workshop series. The main contributions of the paper include i) an examination of the evolving design of the evaluation framework and its components (system tasks, data, measures); ii) an analysis of the influence of topic characteristics (such as rigid/non rigid, planar/non-planar, stationary/mobile on performance; iii) a high-level overview of results and best-performing approaches...
March 2017: International Journal of Multimedia Information Retrieval
https://www.readbyqxmd.com/read/28756623/spatial-and-temporal-drivers-of-avian-population-dynamics-across-the-annual-cycle
#19
Clark S Rushing, Jeffrey A Hostetler, T Scott Sillett, Peter P Marra, James A Rotenberg, Thomas B Ryder
Untangling the spatial and temporal processes that influence population dynamics of migratory species is challenging, because changes in abundance are shaped by variation in vital rates across heterogeneous habitats and throughout the annual cycle. We developed a full-annual-cycle, integrated population model and used demographic data collected between 2011 and 2014 in southern Indiana and Belize to estimate stage-specific vital rates of a declining migratory songbird, the Wood Thrush (Hylocichla mustelina)...
July 30, 2017: Ecology
https://www.readbyqxmd.com/read/28754045/implementing-the-namaste-care-program-for-residents-with-advanced-dementia-exploring-the-perceptions-of-families-and-staff-in-uk-care-homes
#20
Min Stacpoole, Jo Hockley, Amanda Thompsell, Joyce Simard, Ladislav Volicer
BACKGROUND: Increasing numbers of older people with advanced dementia are cared for in care homes. No cure is available, so research focused on improving quality of life and quality of care for people with dementia is needed to support them to live and die well. The Namaste Care programme is a multi-dimensional care program with sensory, psycho-social and spiritual components intended to enhance quality of life and quality of care for people with advanced dementia. The aim of the study was to establish whether the Namaste Care program can be implemented in UK care homes; and what effect Namaste Care has on the quality of life of residents with advanced dementia, their families and staff...
October 2017: Annals of Palliative Medicine
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