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https://www.readbyqxmd.com/read/29035191/idh-mutant-giant-cell-glioblastoma-a-neglected-tumor-variant
#1
Henning Leske, Petter Brandal, Elisabeth J Rushing, Pitt Niehusmann
No abstract text is available yet for this article.
October 16, 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/29031090/recreational-drug-use-and-risk-of-hiv-infection-among-men-who-have-sex-with-men-a-cross-sectional-study-in-shenzhen-china
#2
Chenlin Duan, Lan Wei, Yitian Cai, Lin Chen, Zhengrong Yang, Wei Tan, Yongxia Gan, William W Au, Jin Zhao
BACKGROUND: Recreational drug use has increased in recent years, especially among MSM, and has been found to be associated with higher risk of HIV infection. However, there is limited information about current recreational drug use among MSM in Shenzhen which is an international gateway city to China with a rapidly expanding MSM population. METHODS: A cross-sectional survey among MSM in Shenzhen was conducted and was used to collected information on demographics, sexual behavior and drug use via questionnaires...
October 2, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29029040/herbacetin-suppresses-cutaneous-squamous-cell-carcinoma-and-melanoma-cell-growth-by-targeting-akt-and-odc
#3
Dong Joon Kim, Mee-Hyun Lee, KangDong Liu, Do Young Lim, Eunmiri Roh, Hanyong Chen, Sung-Hyun Kim, Jung-Hyun Shim, Myoung Ok Kim, Wenwen Li, Fayang Ma, Mangaladoss Fredimoses, Ann M Bode, Zigang Dong
Herbacetin is a flavonol compound that is found in plants such as flaxseed and ramose scouring rush herb, it possesses a strong antioxidant capacity, and exerts anticancer effects on colon and breast cancer. However, the effect of herbacetin on skin cancer has not been investigated. Herein, we identified herbacetin as a dual V-akt murine thymoma viral oncogene homolog (AKT) and ornithine decarboxylase (ODC) inhibitor, and illustrated its anticancer effects in vitro and in vivo against cutaneous squamous cell carcinoma (SCC) and melanoma cell growth...
September 23, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29028904/considerations-for-clinical-neuropsychological-evaluation-in-amyotrophic-lateral-sclerosis
#4
Susan C Woolley, Beth K Rush
The clinical neuropsychologist has the opportunity to be uniquely involved in the evaluation and treatment of individuals with amyotrophic lateral sclerosis (ALS). We review the current literature that defines cognitive and behavioral symptoms in ALS, including current knowledge of the neuropathological and genetic underpinning for these symptoms. There are unique considerations for clinical neuropsychological evaluation and clinical research in ALS and we highlight these in this review. Specifically, we shed light on special factors that contribute to our understanding of cognitive and behavioral impairment in ALS, including co-morbid symptoms, differential diagnosis, and considerations for longitudinal tracking of phenotypes...
September 28, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29028556/buspirone-maintenance-does-not-alter-the-reinforcing-subjective-and-cardiovascular-effects-of-intranasal-methamphetamine
#5
Anna R Reynolds, Justin C Strickland, William W Stoops, Joshua A Lile, Craig R Rush
BACKGROUND: Medications development efforts for methamphetamine-use disorder have targeted central monoamines because these systems are directly involved in the effects of methamphetamine. Buspirone is a dopamine autoreceptor and D3 receptor antagonist and partial agonist at serotonin 1A receptors, making it a logical candidate medication for methamphetamine-use disorder. Buspirone effects on abuse-related behaviors of methamphetamine have been mixed in clinical and preclinical studies...
September 22, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29023504/the-potential-of-small-unmanned-aircraft-systems-for-the-rapid-detection-of-threatened-unimproved-grassland-communities-using-an-enhanced-normalized-difference-vegetation-index
#6
Conor J Strong, Niall G Burnside, Dan Llewellyn
The loss of unimproved grassland has led to species decline in a wide range of taxonomic groups. Agricultural intensification has resulted in fragmented patches of remnant grassland habitat both across Europe and internationally. The monitoring of remnant patches of this habitat is critically important, however, traditional surveying of large, remote landscapes is a notoriously costly and difficult task. The emergence of small-Unmanned Aircraft Systems (sUAS) equipped with low-cost multi-spectral cameras offer an alternative to traditional grassland survey methods, and have the potential to progress and innovate the monitoring and future conservation of this habitat globally...
2017: PloS One
https://www.readbyqxmd.com/read/29021887/a-modified-technique-of-fixation-for-proximal-femoral-valgus-osteotomy-in-abnormal-bone-a-report-of-two-cases
#7
S Logheswaren, A R Sulaiman, I Munajat
The ideal size of intramedullary device to fix corrective osteotomy of proximal femur in abnormal bone in children and small patients may not be easily available. We report the successful use of Rush rod in combination with multiple Kirschner wires to fix the corrective osteotomy of coxa vara and shepherd crook deformity in two patients with osteogenesis imperfecta and fibrous dysplasia. The union was achieved on time, neck shaft angle and rotation were maintained.
July 2017: Malaysian Orthopaedic Journal
https://www.readbyqxmd.com/read/29021255/the-molecular-mechanism-of-n-acetylglucosamine-side-chain-attachment-to-the-lancefield-group-a-carbohydrate-in-streptococcus-pyogenes
#8
Jeffrey S Rush, Rebecca J Edgar, Pan Deng, Jing Chen, Haining Zhu, Nina M van Sorge, Andrew J Morris, Konstantin V Korotkov, Natalia Korotkova
In many Lactobacillales species (i.e. lactic acid bacteria), peptidoglycan is decorated by polyrhamnose polysaccharides that are critical for cell envelope integrity and cell shape and also represent key antigenic determinants. Despite the biological importance of these polysaccharides, their biosynthetic pathways have received limited attention. The important human pathogen, Streptococcus pyogenes, synthesizes a key antigenic surface polymer-the Lancefield group A carbohydrate (GAC). GAC is covalently attached to peptidoglycan and consists of a polyrhamnose polymer, with N-acetylglucosamine (GlcNAc) side chains, which is an essential virulence determinant...
October 11, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29017375/hiv-nurse-navigation-charting-the-course-to-improve-engagement-in-care-and-hiv-virologic-suppression
#9
Octaviana Hemmy Asamsama, Leah Squires, Alpha Tessema, Ephrem Rae, Karen Hall, Rush Williams, Debra Benator
This study represents one of the few exploring the effectiveness of an integrated HIV nurse navigation program on engagement and virologic outcomes. A navigator provided individualized care management (eg, pillbox renewals), intensive outreach, and collaboration with existing support systems (eg, families, community programs). Clinical data from the Veterans Affairs (VA) Medical Center site of a longitudinal, observational study of HIV in the District of Columbia (DC) cohort were used for comparison (N = 706)...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/29016713/heavy-drinkers-and-the-potential-impact-of-minimum-unit-pricing-no-single-or-simple-effect
#10
J Gill, H Black, R Rush, F O'May, J Chick
Aims: To explore the potential impact of a minimum unit price (MUP: 50 pence per UK unit) on the alcohol consumption of ill Scottish heavy drinkers. Methods: Participants were 639 patients attending alcohol treatment services or admitted to hospital with an alcohol-related condition. From their reported expenditure on alcohol in their index week, and assuming this remained unchanged, we estimated the impact of a MUP (50 ppu) on future consumption. (Around 15% purchased from both the more expensive on-sale outlets (hotels, pubs, bars) and from off-sales (shops and supermarkets)...
September 7, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29016492/characterizing-the-functional-decline-of-older-women-with-incident-urinary-incontinence
#11
Candace Parker-Autry, Denise K Houston, Julia Rushing, Holly E Richter, Leslee Subak, Alka M Kanaya, Stephen B Kritchevsky
OBJECTIVE: To characterize change in physical performance and differential prevalence of low skeletal muscle mass and strength (sarcopenia) and lower 25-hydroxyvitamin D concentrations among older women who developed urinary incontinence (UI) symptoms. METHODS: This is a secondary analysis of the Health, Aging, and Body Composition Study. Urinary incontinence symptoms were assessed using validated questions. The Short Physical Performance Battery measured physical performance...
October 6, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28993814/a-dopamine-receptor-genetic-variant-enhances-perceptual-speed-in-cognitive-healthy-subjects
#12
S Barral, C Habeck, E Gazes, P L De Jager, D A Bennett, Y Stern
Cognition is under strong genetic control, yet the specific genes are unknown. To investigate genetic influences on specific cognitive domains, 153 cognitive healthy subjects of European ancestry from the Reference Abilities Study (RANN) were genotyped for 1,160 variants within 446 neuropsychiatric genes. Adjusted linear regression models evaluated the association between the genetic variants and four reference abilities, which capture variance in age-related cognitive function (Vocabulary, Episodic Memory, Perceptual Speed, and Reasoning)...
June 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/28988081/measurements-of-nonvolatile-size-distribution-and-its-link-to-traffic-soot-in-urban-shanghai
#13
Shuqin Jiang, Xingnan Ye, Ruyu Wang, Ye Tao, Zhen Ma, Xin Yang, Jianmin Chen
Measurements of particle size distribution and size-resolved particle volatility were conducted using a volatility tandem differential mobility analyzers (V-TDMA) in the urban area of Shanghai during wintertime in January 2014. The nonvolatile mode particles with VSF exceeding 0.85 were always externally mixed with more-volatile mode particles. The average VSF ranged from 0.58 to 0.65 for 100-400nm particles, increasing with the increase of particle size. On average, the nonvolatile mode contributed 15-20% of number fraction for 50-400nm particles...
October 4, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28986963/development-and-evaluation-of-pure-rush-an-online-serious-game-for-drug-education
#14
Lexine A Stapinski, Bill Reda, Nicola C Newton, Siobhan Lawler, Daniel Rodriguez, Catherine Chapman, Maree Teesson
INTRODUCTION AND AIMS: Learning is most effective when it is active, enjoyable and incorporates feedback. Past research demonstrates that serious games are prime candidates to utilise these principles, however the potential benefits of this approach for delivering drug education are yet to be examined in Australia, a country where drug education in schools is mandatory. DESIGN AND METHODS: The serious game 'Pure Rush' was developed across three stages. First, formative consultation was conducted with 115 students (67% male, aged 15-17 years), followed by feasibility and acceptability testing of a prototype of the game (n = 25, 68% male)...
October 6, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/28984491/monitoring-for-antidepressant-associated-adverse-events-in-the-treatment-of-patients-with-major-depressive-disorder-an-international-consensus-statement
#15
Seetal Dodd, Philip B Mitchell, Michael Bauer, Lakshmi Yatham, Allan H Young, Sidney H Kennedy, Lana Williams, Trisha Suppes, Carlos Lopez Jaramillo, Madhukar H Trivedi, Maurizio Fava, A John Rush, Roger S McIntyre, Michael E Thase, Raymond W Lam, Emanuel Severus, Siegfried Kasper, Michael Berk
OBJECTIVES: These recommendations were designed to ensure safety for patients with major depressive disorder (MDD) and to aid monitoring and management of adverse effects during treatment with approved antidepressant medications. The recommendations aim to inform prescribers about both the risks associated with these treatments and approaches for mitigating such risks. METHODS: Expert contributors were sought internationally by contacting representatives of key stakeholder professional societies in the treatment of MDD (ASBDD, CANMAT, WFSBP and ISAD)...
October 6, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28982603/in-vitro-infectivity-of-oncolytic-newcastle-disease-virus-correlation-between-plaque-and-fluorescent-focus-assays
#16
Benjamin S Rush, Melissa L Coughlin, Gautam Sanyal
Newcastle Disease Virus (NDV) is an avian paramyxovirus that has no significant pathogenicity in humans. Cancer cells with impaired immune defense mechanisms are susceptible to infection and lysis by NDV. A recombinant construct of a lentogenic form of NDV (rNDV) containing an insertion of granulocyte macrophage colony stimulating factor (GMCSF) transgene was earlier reported and shown to have acceptably low avian pathogenicity as well as oncolytic potential. Reliable measurement of infectious titer is key to determining the effectiveness of virus preparations to infect and lyse cells...
October 2, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28975501/understanding-factors-that-influence-health-care-utilization-among-mixtec-and-zapotec-women-in-a-farmworker-community-in-california
#17
Annette E Maxwell, Sandra Young, Emily Moe, Roshan Bastani, Emily Wentzell
This paper examines health care utilization among indigenous immigrants from Oaxaca, Mexico, who have settled in a farmworker community in southern California. In 2016, two trained Spanish-Mixteco and Spanish-Zapoteco bi-lingual interviewers conducted in-depth interviews with 44 indigenous women residing in Oxnard, California on issues that affect health care utilization. Interviews were conducted in Mixteco, Zapoteco and Spanish and were coded to identify structural, cultural, and provider-related barriers to health care utilization...
October 3, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28973598/the-rush-to-publication-an-editorial-and-scientific-mistake
#18
EDITORIAL
Howard Bauchner
No abstract text is available yet for this article.
September 26, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28972634/students-perceptions-of-a-poem-to-evaluate-learning-a-qualitative-study
#19
Mitzi M Saunders, Sonya L Kowalski, Suzanne Weathers
BACKGROUND: How best to use poetry in nursing education remains uncertain. This study explored students' perceptions of incorporating a poem into a final examination to evaluate learning in an advanced physical assessment course. METHOD: Qualitative design and method were used to collect and analyze data retrieved from private interviews with seven graduate nursing students. RESULTS: The themes were Being There, Think More, and Feeling Rushed...
October 1, 2017: Journal of Nursing Education
https://www.readbyqxmd.com/read/28963369/tools-for-the-cryo-em-gold-rush-going-from-the-cryo-em-map-to-the-atomistic-model
#20
Doo Nam Kim, Karissa Sanbonmatsu
As cryo electron microscopy (Cryo-EM) enters mainstream structural biology, the demand for fitting methods is high. Here, we explain the importance of flexible fitting for Cryo-EM, potential concerns and assessment methods of this approach, and review existing methods. We aim to give readers concrete descriptions of Cryo-EM flexible fitting methods with corresponding examples.
September 29, 2017: Bioscience Reports
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