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https://www.readbyqxmd.com/read/29467321/development-of-mk-8353-an-orally-administered-erk1-2-inhibitor-in-patients-with-advanced-solid-tumors
#1
Stergios J Moschos, Ryan J Sullivan, Wen-Jen Hwu, Ramesh K Ramanathan, Alex A Adjei, Peter C Fong, Ronnie Shapira-Frommer, Hussein A Tawbi, Joseph Rubino, Thomas S Rush, Da Zhang, Nathan R Miselis, Ahmed A Samatar, Patrick Chun, Eric H Rubin, James Schiller, Brian J Long, Priya Dayananth, Donna Carr, Paul Kirschmeier, W Robert Bishop, Yongqi Deng, Alan Cooper, Gerald W Shipps, Blanca Homet Moreno, Lidia Robert, Antoni Ribas, Keith T Flaherty
BACKGROUND: Constitutive activation of ERK1/2 occurs in various cancers, and its reactivation is a well-described resistance mechanism to MAPK inhibitors. ERK inhibitors may overcome the limitations of MAPK inhibitor blockade. The dual mechanism inhibitor SCH772984 has shown promising preclinical activity across various BRAFV600/RAS-mutant cancer cell lines and human cancer xenografts. METHODS: We have developed an orally bioavailable ERK inhibitor, MK-8353; conducted preclinical studies to demonstrate activity, pharmacodynamic endpoints, dosing, and schedule; completed a study in healthy volunteers (P07652); and subsequently performed a phase I clinical trial in patients with advanced solid tumors (MK-8353-001)...
February 22, 2018: JCI Insight
https://www.readbyqxmd.com/read/29464433/optimizing-travel-time-to-outpatient-interventional-radiology-procedures-in-a-multi-site-hospital-system-using-a-google-maps-application
#2
Jacob E Mandel, Louis Morel-Ovalle, Franz E Boas, Etay Ziv, Hooman Yarmohammadi, Amy Deipolyi, Heeralall R Mohabir, Joseph P Erinjeri
The purpose of this study is to determine whether a custom Google Maps application can optimize site selection when scheduling outpatient interventional radiology (IR) procedures within a multi-site hospital system. The Google Maps for Business Application Programming Interface (API) was used to develop an internal web application that uses real-time traffic data to determine estimated travel time (ETT; minutes) and estimated travel distance (ETD; miles) from a patient's home to each a nearby IR facility in our hospital system...
February 20, 2018: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/29460639/planning-telehealth-for-older-adults-with-atrial-fibrillation-in-rural-communities-understanding-stakeholder-perspectives
#3
Kathy L Rush, Linda Hatt, Nicole Gorman, Louann Janicki, Petr Polasek, Matt Shay
Older adults with atrial fibrillation (AF) in rural communities have less access to cardiac specialty care. Telehealth offers a viable approach to provide cardiac care, yet little is known about patients' and providers' views on telehealth's potential to support rural patients with AF. This qualitative descriptive study examines patient and health providers' perspectives, an important first step in planning a telehealth initiative. Eight patients with AF, along with one partner from rural communities, were recruited through an urban-based AF clinic...
February 1, 2018: Clinical Nursing Research
https://www.readbyqxmd.com/read/29460557/-errors-in-medicine-perceptions-of-nursing-students-in-rome
#4
Massimiliano Chiarini, Emilia De Vita, Angela Meggiolaro, Silvia Miccoli, Gaetana Maria Grazia Stricchiola, Giuseppe Alberto Grande, Maria Luisa Veneziano, Anna Santa Guzzo, Giuseppe La Torre
INTRODUCTION: The error in medicine has long been discussed in scientific debates. The purpose of this study is to evaluate the degree knowledge, attitude and behavior of students in Nursing for the failure in the health sector. METHODS: It was administered to 231 students of Nursing of the Sapienza University of Rome (171 females and 60 males), aged between 21 and 45 years, a structured questionnaire in three questions that explore the experiences and opinions about the errors found in medical practice, the causes underlying them and the mistakes that should never be committed...
October 2017: Professioni Infermieristiche
https://www.readbyqxmd.com/read/29456016/monoclonal-antibody-based-in-vitro-potency-assay-as-a-predictor-of-antigenic-integrity-and-in-vivo-immunogenicity-of-a-respiratory-syncytial-virus-post-fusion-f-protein-based-vaccine
#5
Matieyendou Didier Djagbare, Li Yu, Arun Parupudi, Jenny Sun, Melissa L Coughlin, Benjamin S Rush, Gautam Sanyal
The post-fusion form of Respiratory Syncytial Virus (RSV) fusion (F) protein has been used recently in clinical trials as a potential vaccine antigen with the objective of eliciting protective immune response against RSV. In this paper, in vitro antigenicity and in vivo immunogenicity of recombinant, soluble F protein of RSV (RSVsF) were evaluated by several assays. In Vitro Relative Potency (IVRP) of RSVsF was measured in a sandwich ELISA using two antibodies, each specific for epitope site A or C. Therefore, IVRP reflected the integrity of the antigen in terms of changes in antibody binding affinity of either or both of these sites...
February 15, 2018: Vaccine
https://www.readbyqxmd.com/read/29453168/spatial-temporal-cluster-analysis-of-mortality-from-road-traffic-injuries-using-geographic-information-systems-in-west-of-iran-during-2009-2014
#6
Alireza Zangeneh, Farid Najafi, Saeed Karimi, Shahram Saeidi, Neda Izadi
INTRODUCTION: Road traffic injuries (RTIs) are considered as one of the most important health problems endangering people's life. The examination of the geographical distribution of RTIs could help policymakers in better planning to reduce RTIs. This study, therefore, aimed to determine the spatial-temporal clustering of mortality from RTIs in West of Iran. METHODS: Deaths from RTIs, registered in Forensic Medicine Organization of Kermanshah province over a period of six years (2009-2014), were used...
February 8, 2018: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29452590/factors-associated-with-persistent-posttraumatic-stress-disorder-among-u-s-military-service-members-and-veterans
#7
Richard F Armenta, Toni Rush, Cynthia A LeardMann, Jeffrey Millegan, Adam Cooper, Charles W Hoge
BACKGROUND: Posttraumatic stress disorder (PTSD) can have long-term and far-reaching impacts on health and social and occupational functioning. This study examined factors associated with persistent PTSD among U.S. service members and veterans. METHODS: Using baseline and follow-up (2001-2013) questionnaire data collected approximately every 3 years from the Millennium Cohort Study, multivariable logistic regression was conducted to determine factors associated with persistent PTSD...
February 17, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29446519/a-plateau-in-new-onset-type-1-diabetes-incidence-of-pediatric-diabetes-in-the-united-states-military-health-system
#8
Toni Rush, Megan McGeary, Nicholas Sicignano, Melissa A Buryk
OBJECTIVES: To describe the incidence and prevalence of type 1 diabetes among pediatric dependents of the U.S. Department of Defense (DoD). METHODS: The Military Health System (MHS) Data Repository was used to identify pediatric patients (≤ 17 years of age) with type 1 diabetes from January 1, 2007 to December 31, 2012. Annual incidence, annual prevalence and adjusted incidence were calculated and stratified by sex, age group and region of residence. RESULTS: Within a 6-year study period from 2007-2012, 5,616 pediatric patients with type 1 diabetes were identified; 57% male, mean (SD) age of 10...
February 15, 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/29443460/tracking-the-sugar-rush-incorporating-continuous-glucose-monitoring-into-multisite-early-clinical-research-with-type-2-diabetes-subjects
#9
Sabina Paglialunga, Bruce H Morimoto, Amparo de la Peña, Caroline Fortier
Continuous glucose monitoring (CGM) systems allow patients with diabetes mellitus to closely track glucose concentrations over several days, identify trends in glucose levels, and avoid glucose excursions. This technology has not only advanced diabetes mellitus management but has increased patient safety through greater glycemic awareness. Due to these attributes, CGM is now being applied in therapeutic research as a pharmacodynamic tool to support early clinical drug development programs. However, to date only a handful of studies have utilized CGM in type 2 diabetes mellitus (T2DM) drug development...
February 14, 2018: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29439004/assessing-the-nutrient-intake-of-a-low-carbohydrate-high-fat-lchf-diet-a-hypothetical-case-study-design
#10
Caryn Zinn, Amy Rush, Rebecca Johnson
OBJECTIVE: The low-carbohydrate, high-fat (LCHF) diet is becoming increasingly employed in clinical dietetic practice as a means to manage many health-related conditions. Yet, it continues to remain contentious in nutrition circles due to a belief that the diet is devoid of nutrients and concern around its saturated fat content. This work aimed to assess the micronutrient intake of the LCHF diet under two conditions of saturated fat thresholds. DESIGN: In this descriptive study, two LCHF meal plans were designed for two hypothetical cases representing the average Australian male and female weight-stable adult...
February 8, 2018: BMJ Open
https://www.readbyqxmd.com/read/29436308/development-and-validation-of-the-consumer-health-activation-index
#11
Michael S Wolf, Samuel G Smith, Anjali U Pandit, David M Condon, Laura M Curtis, James Griffith, Rachel O'Conor, Steven Rush, Stacy C Bailey, Gordon Kaplan, Vincent Haufle, David Martin
BACKGROUND: Although there has been increasing interest in patient engagement, few measures are publicly available and suitable for patients with limited health literacy. OBJECTIVE: We sought to develop a Consumer Health Activation Index (CHAI) for use among diverse patients. METHODS: Expert opinion, a systematic literature review, focus groups, and cognitive interviews with patients were used to create and revise a potential set of items...
February 1, 2018: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/29435124/adduction-to-arginine-detoxifies-aflatoxin-b1-by-eliminating-genotoxicity-and-altering-in-vitro-toxicokinetic-profiles
#12
Blake R Rushing, Mustafa I Selim
Aflatoxin B1 (AFB1), a class 1 carcinogen and prominent food contaminant, is highly linked to the development of hepatocellular carcinoma (HCC) and plays a causative role in a large portion of global HCC cases. We have demonstrated that a mixture of common organic acids (citric and phosphoric acid) along with arginine can eliminate >99% of AFB1 in solution as well as on corn kernels and convert it to the AFB2a-Arg adduct, acting as a potential detoxification process for contaminated foods. Evaluation of toxicokinetic changes after AFB2a-Arg formation show that the product is highly stable in biological fluids, is not metabolized by P450 enzymes, is highly plasma protein bound, has low lipid solubility, and has poor intestinal permeability/high intestinal efflux compared to AFB1...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29432610/accelerometer-physical-activity-is-associated-with-greater-gray-matter-volumes-in-older-adults-without-dementia-or-mild-cognitive-impairment
#13
Shannon Halloway, Konstantinos Arfanakis, JoEllen Wilbur, Michael E Schoeny, Susan J Pressler
Objectives: Physical activity (PA) is a modifiable health behavior that can protect against age-related gray matter atrophy and cognitive dysfunction. Current studies of PA and gray matter failed to utilize device measures of PA and do not focus on adults >80 years. Thus, the purpose of this secondary analysis was to examine cross-sectional associations between accelerometer lifestyle PA and (a) gray matter volumes and (b) cognitive function, controlling for demographics and health status...
February 8, 2018: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/29427149/phase-i-trial-of-dasatinib-lenalidomide-and-temozolomide-in-children-with-relapsed-or-refractory-central-nervous-system-tumors
#14
Nathan J Robison, Kee Kiat Yeo, Adrian P Berliner, Jemily Malvar, Michael A Sheard, Ashley S Margol, Robert C Seeger, Teresa Rushing, Jonathan L Finlay, Richard Sposto, Girish Dhall
Single agent studies targeting the tumor microenvironment in central nervous system (CNS) tumors have largely been disappointing. Combination therapies targeting various pathways and cell types may be a more effective strategy. In this phase I study, we evaluated the combination of dasatinib, lenalidomide, and temozolomide in children with relapsed or refractory primary CNS tumors. Patients 1-21 years old with relapsed or refractory CNS tumors were eligible. Starting doses of dasatinib and lenalidomide were 65 mg/m 2 /dose twice daily and 55 mg/m 2 once daily, respectively, while temozolomide was constant at 75 mg/m 2 daily...
February 9, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29427093/comparison-between-locked-and-unlocked-intramedullary-nails-in-intertrochanteric-fractures
#15
Riccardo Maria Lanzetti, Auro Caraffa, Domenico Lupariello, Paolo Ceccarini, Giulio Gambaracci, Luigi Meccariello, Francesco Manfreda, Daniele Maiettini, Cristina Ibáñez Vicente, Michele Scialpi, Olga Bisaccia, Giuseppe Rinonapoli, Michele Bisaccia
BACKGROUND: Intertrochanteric fractures are of great interest worldwide and are the most frequently operated fractures. Intramedullary nailing is commonly used in the treatment of intertrochanteric fractures. The purpose of this study is to assess the necessity of using the distal blocking screw in 31-A1 and 31-A2 fractures, classified according to the Orthopaedic Trauma Association classification system (AO/OTA). METHODS: This is a prospective study of 143 consecutive patients (mean age 85...
February 9, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29426653/postoperative-symptom-distress-of-laparoscopic-cholecystectomy-ambulatory-surgery-patients
#16
Jan Odom-Forren, Deborah B Reed, Carrell Rush
PURPOSE: The purposes of this study were to (1) identify symptoms that cause postoperative distress in ambulatory surgery patients; (2) identify symptom management techniques that effectively reduce distress of laparoscopic cholecystectomy (LC) postoperative symptoms at home after ambulatory surgery; and (3) identify facilitators and barriers to self-management of postoperative symptoms. DESIGN: A qualitative descriptive study. METHODS: Two focus groups of ambulatory surgery patients who had experienced a laparoscopic cholecystectomy procedure and their caregivers were queried to elicit understanding of postoperative symptoms and symptom management techniques...
February 6, 2018: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
https://www.readbyqxmd.com/read/29426152/determining-factors-for-levels-of-volatile-organic-compounds-measured-in-different-microenvironments-of-a-heavy-traffic-urban-area
#17
Nguyen Hong Phuc, Nguyen Thi Kim Oanh
The levels of BTEX (benzene, toluene, ethylbenzene and xylenes) in a congested urban area of Hanoi were characterized in a winter and a transitional period in 2015. Monitoring was conducted at two roads simultaneously with traffic flows and one ambient site together with meteorology. Hourly and bi-hourly BTEX samples collected using charcoal tubes were analyzed by GC-FID. BTEX levels in winter, 131 ± 71 μg/m3 in heavy traffic Truong Chinh (TC) road, 101 ± 29 μg/m3 in small residential Nguyen Ngoc Nai (NN) road, and 30 ± 15 μg/m3 in the ambient air site (AA, about 150 m from each road) were 1...
January 29, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29423683/a-phase-i-study-of-afatinib-for-patients-aged-75-or-older-with-advanced-non-small-cell-lung-cancer-harboring-egfr-mutations
#18
Hisashi Tanaka, Kageaki Taima, Yoshihito Tanaka, Masamichi Itoga, Yoshiko Ishioka, Hideyuki Nakagawa, Keisuke Baba, Yukihiro Hasegawa, Shingo Takanashi, Sadatomo Tasaka
This phase I trial was conducted to determine the maximum tolerated dose (MTD) and recommended dose of afatinib for phase II trial in elderly patients with advanced non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations. The study used a standard 3 + 3 dose escalation design. Patients aged 75 years or older with advanced NSCLC harboring EGFR mutations were enrolled. The doses of afatinib, which were given once daily, were planned as follows: level 1, 20 mg/day; level 2, 30 mg/day; level 3, 40 mg/day...
February 8, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29419766/-i-always-feel-like-i-have-to-rush%C3%A2-pet-owner-and-small-animal-veterinary-surgeons-reflections-on-time-during-preventative-healthcare-consultations-in-the-united-kingdom
#19
Zoe Belshaw, Natalie J Robinson, Rachel S Dean, Marnie L Brennan
Canine and feline preventative healthcare consultations can be more complex than other consultation types, but they are typically not allocated additional time in the United Kingdom (UK). Impacts of the perceived length of UK preventative healthcare consultations have not previously been described. The aim of this novel study was to provide the first qualitative description of owner and veterinary surgeon reflections on time during preventative healthcare consultations. Semi-structured telephone interviews were conducted with 14 veterinary surgeons and 15 owners about all aspects of canine and feline preventative healthcare consultations...
February 8, 2018: Veterinary Sciences
https://www.readbyqxmd.com/read/29419715/spine-trauma-from-personal-watercraft-usage
#20
Chester J Donnally, Gil Metser, Eric S Roth, Justin P Moo Young, Augustus J Rush, Motasem A Al Maaieh
STUDY DESIGN: Retrospective cohort study OBJECTIVE.: To identify patient characteristics and associated injuries in those sustaining a spine fracture from personal watercraft (PWC) usage. SUMMARY OF BACKGROUND DATA: There are few studies regarding PWC use and injuries, and even more scarce are studies evaluating PWC usage and spine injuries. Identifying high risk actions and individuals can help to effectively treat them, reduce mortality, and possibly avoid certain spine fractures...
February 6, 2018: Spine
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