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https://www.readbyqxmd.com/read/29682291/metformin-in-gestational-diabetes-the-offspring-follow-up-mig-tofu-body-composition-and-metabolic-outcomes-at-7-9-years-of-age
#1
Janet A Rowan, Elaine C Rush, Lindsay D Plank, Jun Lu, Victor Obolonkin, Suzette Coat, William M Hague
Objective: To compare body composition and metabolic outcomes at 7-9 years in offspring of women with gestational diabetes (GDM) randomized to metformin (±insulin) or insulin treatment during pregnancy. Research design and methods: Children were assessed at 7 years in Adelaide (n=109/181) and 9 years in Auckland (n=99/396) by anthropometry, bioimpedance analysis (BIA), dual-energy X-ray absorptiometry (DXA), magnetic resonance imaging (MRI) (n=92/99) and fasting bloods (n=82/99)...
2018: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29677642/diagnostic-value-of-18-f-fluordesoxyglucose-positron-emission-tomography-for-patients-with-brain-metastasis-from-unknown-primary-site
#2
Fabian Wolpert, Michael Weller, Anna Sophie Berghoff, Elisabeth Rushing, Lisa Michaela Füreder, Gregory Petyt, Henning Leske, Nicolaus Andratschke, Luca Regli, Marian Christoph Neidert, Roger Stupp, Rolf Stahel, Reinhard Dummer, Thomas Frauenfelder, Patrick Roth, Nicolas Reyns, Philipp Antonio Kaufmann, Matthias Preusser, Emilie Le Rhun
BACKGROUND: In 30% of patients with brain metastasis (BM), neurological symptoms are the first clinical manifestation of systemic malignancy, referred to as BM from cancer of unknown primary site (BM-CUPS). Here, we define the diagnostic value of 18 F-fluordesoxyglucose positron emission tomography (FDG-PET/CT) in the workup of BM-CUPS. METHODS: We screened 565 patients operated for BM at the University Hospital Zurich and identified 64 patients with BM-CUPS with data on both FDG-PET/CT and contrast-enhanced chest/abdomen computed tomography (CT) available at BM diagnosis...
April 17, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29672468/investigating-the-extent-realistic-moulage-impacts-on-immersion-and-performance-among-undergraduate-paramedicine-students-in-a-simulation-based-trauma-scenario-a-pilot-study
#3
Brennen W Mills, Alecka K Miles, Tina Phan, Peggy M C Dykstra, Sara S Hansen, Andrew S Walsh, David N Reid, Claire Langdon
INTRODUCTION: Many healthcare education commentators suggest that moulage can be used in simulation to enhance scenario realism. However, few studies investigate to what extent using moulage in simulation impacts learners. We undertook a mixed-methods pilot study investigating how moulage influences student immersion and performance in simulation. METHODS: Fifty undergraduate paramedicine students were randomized into two groups completing a trauma-based scenario with or without patient moulage...
April 18, 2018: Simulation in Healthcare: Journal of the Society for Simulation in Healthcare
https://www.readbyqxmd.com/read/29669354/effectiveness-and-safety-of-pylera%C3%A2-in-patients-infected-by-helicobacter-pylori-a-multicenter-retrospective-real-life-study
#4
Antonio Tursi, Marilisa Franceschi, Leonardo Allegretta, Edoardo Savarino, Rudi De Bastiani, Walter Elisei, Gianluca Baldassarre, Antonio Ferronato, Serena Scida, Chiara Miraglia, Antonio Penna, Claudio Licci, Giovanni Luca Rizzo, Giuseppe Pranzo, Claudio Cassieri, Giovanni Brandimarte, Marcello Picchio, Francesco Di Mario
BACKGROUND: Our aims were to assess the real life effectiveness and safety of the new bismuth-containing quadruple therapy in a large population of patients infected by Helicobacter pylori. METHODS: Consecutive dyspeptic H. pylori-positive patients were enrolled, both naïve for treatment and already unsuccessfully treated. Patients were treated with Pylera® 3 capsules 4 times/daily plus omeprazole 20 mg or esomeprazole 40 mg 2 times/daily for 10 days. Eradication was confirmed using a urea-breath test (at least 30 days after the end of the treatment)...
April 17, 2018: Digestive Diseases
https://www.readbyqxmd.com/read/29665785/new-types-of-drug-use-and-risks-of-drug-use-among-men-who-have-sex-with-men-a-cross-sectional-study-in-hangzhou-china
#5
Lin He, Xiaohong Pan, Ning Wang, Jiezhe Yang, Jun Jiang, Yan Luo, Xingliang Zhang, Xiting Li
BACKGROUND: The use of new types of drugs has become more common among men who have sex with men (MSM). The aim of this study was to describe the patterns of the use of new types of drugs, such as methamphetamine, ketamine, ecstasy, and rush poppers, and to examine the factors associated with drug use and HIV infection among MSM in Hangzhou, China. METHODS: This cross-sectional study was conducted between August 2015 and April 2016. We used snowball sampling to recruit MSM; participants were recruited from voluntary counseling and testing centers, baths, bars, Blued (an app for the gay community), QQ groups, clubs, and other types of venues...
April 17, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29665205/characterization-of-the-in-vitro-and-in-vivo-properties-of-cfz533-a-blocking-and-non-depleting-anti-cd40-monoclonal-antibody
#6
Jacinda Ristov, Pascal Espie, Peter Ulrich, Denise Sickert, Thierry Flandre, Mirela Dimitrova, Dorothee Müller-Ristig, Doris Weider, Gautier Robert, Patrick Schmutz, Barbara Greutmann, Francisco Cordoba-Castro, Martin A Schneider, Max Warncke, Frank Kolbinger, Serge Cote, Christoph Heusser, Christian Bruns, James S Rush
The CD40-CD154 co-stimulatory pathway is essential for T cell-dependent immune responses, development of humoral memory and antigen presenting cell function. These immune functions have been implicated in the pathology of multiple autoimmune diseases as well as allograft rejection. We have generated CFZ533, a fully human, pathway blocking anti-CD40 monoclonal antibody that has been modified with a N297A mutation to render it unable to mediate Fcγ-dependent effector functions. CFZ533 inhibited CD154-induced activation of human leukocytes in vitro, but failed to induce human leukocyte activation...
April 17, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29664913/cost-benefit-analysis-of-introducing-next-generation-sequencing-metagenomic-pathogen-testing-in-the-setting-of-pyrexia-of-unknown-origin
#7
Jia Hui Chai, Chun Kiat Lee, Hong Kai Lee, Nicholas Wong, Kahwee Teo, Chuen Seng Tan, Praveen Thokala, Julian Wei-Tze Tang, Paul Anantharajah Tambyah, Vernon Min Sen Oh, Tze Ping Loh, Joanne Yoong
Pyrexia of unknown origin (PUO) is defined as a temperature of >38.3°C that lasts for >3 weeks, where no cause can be found despite appropriate investigation. Existing protocols for the work-up of PUO can be extensive and costly, motivating the application of recent advances in molecular diagnostics to pathogen testing. There have been many reports describing various analytical methods and performance of metagenomic pathogen testing in clinical samples but the economics of it has been less well studied...
2018: PloS One
https://www.readbyqxmd.com/read/29660848/international-collaborative-study-to-assess-cardiovascular-risk-and-evaluate-long-term-health-in-cats-with-preclinical-hypertrophic-cardiomyopathy-and-apparently-healthy-cats-the-reveal-study
#8
Philip R Fox, Bruce W Keene, Kenneth Lamb, Karsten A Schober, Valerie Chetboul, Virginia Luis Fuentes, Gerhard Wess, Jessie Rose Payne, Daniel F Hogan, Alison Motsinger-Reif, Jens Häggström, Emilie Trehiou-Sechi, Deborah M Fine-Ferreira, Reid K Nakamura, Pamela M Lee, Manreet K Singh, Wendy A Ware, Jonathan A Abbott, Geoffrey Culshaw, Sabine Riesen, Michele Borgarelli, Michael B Lesser, Nicole Van Israël, Etienne Côté, John E Rush, Barret Bulmer, Roberto A Santilli, Andrea C Vollmar, Maribeth J Bossbaly, Nadine Quick, Claudio Bussadori, Janice M Bright, Amara H Estrada, Dan G Ohad, Maria Josefa Fernández-Del Palacio, Jenifer Lunney Brayley, Denise S Schwartz, Christina M Bové, Sonya G Gordon, Seung Woo Jung, Paola Brambilla, N Sydney Moïse, Christopher D Stauthammer, Rebecca L Stepien, Cecilia Quintavalla, Christophe Amberger, Ferenc Manczur, Yong-Wei Hung, Remo Lobetti, Marie De Swarte, Alice Tamborini, Carmel T Mooney, Mark A Oyama, Andrey Komolov, Yoko Fujii, Romain Pariaut, Masami Uechi, Victoria Yukie Tachika Ohara
BACKGROUND: Hypertrophic cardiomyopathy is the most prevalent heart disorder in cats and principal cause of cardiovascular morbidity and mortality. Yet, the impact of preclinical disease is unresolved. HYPOTHESIS/OBJECTIVES: Observational study to characterize cardiovascular morbidity and survival in cats with preclinical nonobstructive (HCM) and obstructive (HOCM) hypertrophic cardiomyopathy and in apparently healthy cats (AH). ANIMALS: One thousand seven hundred and thirty client-owned cats (430 preclinical HCM; 578 preclinical HOCM; 722 AH)...
April 16, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29658842/pathogenic-streptomyces-spp-abundance-affected-by-potato-cultivars
#9
Kamrun Nahar, Claudia Goyer, Bernie J Zebarth, David L Burton, Sean Whitney
Potato cultivars vary in their tolerance to common scab (CS), however how they affect CS-causing Streptomyces spp. populations over time is poorly understood. This study investigated the effects of potato cultivar on pathogenic Streptomyces spp. abundance, measured using quantitative PCR, in three spatial locations in a CS-infested field: 1) soil close to the plant (SCP); 2) rhizosphere (RS); and 3) geocaulosphere (GS) soils. Two tolerant (Gold Rush, Hindenburg) and two susceptible cultivars (Green Mountain, Agria) were tested...
April 16, 2018: Phytopathology
https://www.readbyqxmd.com/read/29657377/failure-of-postexposure-prophylaxis-in-a-patient-given-rabies-vaccine-intramuscularly-in-the-gluteus-muscle-himachal-pradesh-india
#10
Omesh Kumar Bharti, Vivek Sharma
A 48-year-old male was bitten by a dog on the forehead and on the RIGHT side of left eyebrow on November 26, 2017, at 2 pm. The patient was immediately rushed to a nearby private hospital where an MBBS doctor gave him immediate wound wash with soap and water and prescribed five doses of rabies vaccine intramuscularly (IM). Since the patient weight was 60 kg, he was also prescribed 2400 IU of equine rabies immunoglobulin (ERIG), but as eRIG was not available, it was not administered. All the four doses of rabies vaccine were given IM in gluteus muscle...
March 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29657095/epidemiology-of-bus-fires-in-mainland-china-from-2006-to-2015
#11
Yong Liu, Pan Wu, Jon Kee Ho, Haiping Hua, Haojiao Chen, Ying Cen, Songxue Guo, Chunmao Han, Xingang Wang
OBJECTIVE: This study analyses the epidemiological characteristics of bus fires in mainland China over the past 10 years to develop prevention strategies and emergency procedures for such incidence and the resulting casualties. METHODS: We collected reports on bus fires from the media and news websites and looked up on Medline, PubMed, and Chinese National Knowledge Infrastructure databases for relevant publications in English or Chinese from January 1, 2006 to December 31, 2015...
April 12, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29656666/can-a-framework-be-established-for-the-safe-use-of-ketamine
#12
Robert Freedman, Alan S Brown, Tyrone D Cannon, Benjamin G Druss, Felton J Earls, Javier Escobar, Yasmin L Hurd, David A Lewis, Carlos López-Jaramillo, Joan Luby, Helen S Mayberg, Terrie E Moffitt, Maria Oquendo, Roy H Perlis, Daniel S Pine, A John Rush, Carol A Tamminga, Mauricio Tohen, Eduard Vieta, Katherine L Wisner, Yu Xin
No abstract text is available yet for this article.
April 16, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29655650/surgical-treatment-of-lisfranc-injury-with-plantar-plate-approach
#13
Deepal Dalal, Christian Curry, Ryan Carter, Colin Zdenek, Nicholas W Todd, Shannon M Rush, Richard Jensen
Midfoot injuries are the second most common athletic foot injury documented in the published data. High-energy Lisfranc dislocations are commonly seen secondary to traumatic etiologies and disrupt the strong midfoot ligaments supporting the arch. These injuries require immediate surgical intervention to prevent serious complications such as compartment syndrome and amputation. The present case series reports a new Lapidus plate system used in 3 patients who underwent arthrodesis procedures for Lisfranc joint dislocation...
April 11, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29651301/caregiver-experiences-of-public-services-following-child-trauma-exposure-a-qualitative-study
#14
Victoria Williamson, Sarah L Halligan, Bronwyne Coetzee, Ian Butler, Mark Tomlinson, Sarah Skeen, Jackie Stewart
Background: Many children in low and middle income countries (LMIC) are exposed to trauma. Contact with public services are a potential influence on parent-child reactions and coping post-trauma. Little is known about how caregivers perceive these interactions. Methods: The aim of this study was to explore caregivers' experiences of accessing and interacting with public services post-trauma and perceptions of needed improvements to public services in a LMIC context...
2018: International Journal of Mental Health Systems
https://www.readbyqxmd.com/read/29651231/procyanidins-a-comprehensive-review-encompassing-structure-elucidation-via-mass-spectrometry
#15
Emily A Rue, Michael D Rush, Richard B van Breemen
Procyanidins are polyphenols abundant in dietary fruits, vegetables, nuts, legumes, and grains with a variety of chemopreventive biological effects. Rapid structure determination of these compounds is needed, notably for the more complex polymeric procyanidins. We review the recent developments in the structure elucidation of procyanidins with a focus on mass spectrometric approaches, especially liquid chromatography-tandem mass spectrometry (LC-MS/MS) and matrix-assisted laser desorption ionization (MALDI) MS/MS...
February 2018: Phytochemistry Reviews: Proceedings of the Phytochemical Society of Europe
https://www.readbyqxmd.com/read/29649812/safety-and-efficacy-of-a-progressively-prolonged-maintenance-interval-of-venom-immunotherapy
#16
Kalliopi Kontou-Fili, Constantinos Pitsios, Evangelia Kompoti, Dionysios Giannakopoulos, Spyros Kouridakis
BACKGROUND: The long-term protection provided by venom immunotherapy (VIT) is related to the dose administered and to its long duration; the latter, however, becomes inconvenient for patients in countries like Greece, with many islanders or inhabitants of distant mountainous areas. Maintenance interval prolongation reduces the number of office visits - saving time and money - and as a consequence contributes to the patients' compliance. The aim of this prospective study was to evaluate the safety and efficacy of VIT on a progressively prolonged maintenance interval (PPMI)...
April 12, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29649762/airborne-ultrafine-particles-in-a-naturally-ventilated-metro-station-dominant-sources-and-mixing-state-determined-by-particle-size-distribution-and-volatility-measurements
#17
Luís Mendes, Maria I Gini, George Biskos, Ian Colbeck, Konstantinos Eleftheriadis
Ultrafine particle number concentrations and size distributions were measured on the platform of a metro station in Athens, Greece, and compared with those recorded at an urban background station. The volatility of the sampled particles was measured in parallel, providing further insights on the mixing state and composition of the sampled particles. Particle concentration exhibited a mean value of 1.2 × 104 # cm-3 and showed a weak correlation with train passage frequency, but exhibited a strong correlation with urban background particle concentrations...
April 9, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29649710/psychometric-properties-of-the-concise-health-risk-tracking-chrt-in-adolescents-with-suicidality
#18
REVIEW
Taryn L Mayes, Betsy D Kennard, Michael Killian, Thomas Carmody, Bruce D Grannemann, A John Rush, Manish K Jha, Jennifer Hughes, Graham J Emslie, Madhukar H Trivedi
BACKGROUND: Several self-report rating scales have been developed to assess suicidal ideation, yet few examine other factors related to increased suicidal risk, and even fewer have been validated in both adolescents and adults. We evaluate the 14-item Concise Health Risk Tracking - Self Report (CHRT-SR), a measure previously validated in adults, in a sample of adolescents at risk for suicide. METHOD: Data are from a retrospective chart review of adolescents treated in an intensive outpatient program for youth with severe suicidality...
March 26, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29648580/bevacizumab-plus-hypofractionated-radiotherapy-versus-radiotherapy-alone-in-elderly-patients-with-glioblastoma-the-randomized-open-label-phase-ii-arte-trial
#19
H-G Wirsching, G Tabatabai, U Roelcke, A F Hottinger, F Jörger, A Schmid, L Plasswilm, D Schrimpf, C Mancao, D Capper, K Conen, T Hundsberger, F Caparrotti, R von Moos, C Riklin, J Felsberg, P Roth, D T W Jones, S Pfister, E J Rushing, L Abrey, G Reifenberger, L Held, A von Deimling, A Ochsenbein, M Weller
Background: The addition of bevacizumab to temozolomide-based chemoradiotherapy (TMZ/RT→TMZ) did not prolong overall survival (OS) in patients with newly diagnosed glioblastoma in phase III trials. Elderly and frail patients are underrepresented in clinical trials, but early reports suggested preferential benefit in this population. Patients and Methods: ARTE was a 2:1 randomized, multi-center, open-label, non-comparative phase II trial of hypofractionated RT (40 Gy in 15 fractions) with bevacizumab (10 mg/kg x 14 days) (arm A, N = 50) or without bevacizumab (arm B, N = 25) in patients with newly diagnosed glioblastoma aged ≥65 years...
April 10, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29628470/a-rare-case-of-rush-progression-of-purulent-pericarditis-by-escherichia-coli-in-a-patient-with-malignant-lymphoma
#20
Shunpei Horii, Hirotaka Yada, Kei Ito, Ayumu Osaki, Atsushi Sato, Toyokazu Kimura, Risako Yasuda, Takumi Toya, Takayuki Namba, Nobuyuki Masaki, Takeshi Adachi
Purulent pericarditis is a rare disease in the antibiotic era. The common pathogens of purulent pericarditis are gram-positive species such as Staphylococcus aureus. Streptococcus pneumoniae, Salmonella, Haemophilus, fungal pathogens/tuberculosis can also result in purulent pericarditis. We report an old male case of purulent pericarditis by Escherichia coli. He came to our hospital suffering from leg edema for 3 months. Echocardiography revealed the large amount of pericardial effusion, and he was admitted to test the cause of pericardial effusion without high fever, tachycardia, and shock vital signs...
April 6, 2018: International Heart Journal
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