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https://www.readbyqxmd.com/read/29031222/apolipoproteins-adsorption-and-brain-targeting-evaluation-of-baicalin-nanocrystals-modified-by-combination-of-tween80-and-tpgs
#1
Yang Liu, Yueqin Ma, Junnan Xu, Yingchong Chen, Jin Xie, Pengfei Yue, Qin Zheng, Ming Yang
To help baicalin pass across BBB and improve its targeting in brain, we designed a novel formulation strategy of baicalin nanocrystals that preferentially adsorbing apolipoprotein E (ApoE) and repelling protein adsorption of opsonins. Intravenous baicalin nanocrystals suspensions (BCL-NS) modified by different surfactant were prepared by high-pressure homogenization. The targeting potential of surface-modified BCL-NS with mean particles size of about 250nm was assessed by in vitro protein adsorption studies using two-dimensional polyacrylamide gel electrophoresis (2-D PAGE), and further evaluated in vivo pharmacokinetics...
October 5, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29031180/design-of-silk-proteins-with-increased-heme-binding-capacity-and-fabrication-of-silk-heme-materials
#2
Trevor D Rapson, Jian-Wei Liu, Alagacone Sriskantha, Mustafa Musameh, Christopher J Dunn, Jeffrey S Church, Andrea Woodhead, Andrew C Warden, Mark J Riley, Jeffrey R Harmer, Christopher J Noble, Tara D Sutherland
In our previous studies, heme was bound into honeybee silk to generate materials that could function as nitric oxide sensors or as recoverable heterogeneous biocatalysts. In this study, we sought to increase the heme-binding capacity of the silk protein by firstly redesigning the heme binding site to contain histidine as the coordinating residue and secondly, by adding multiple histidine residues within the core of the coiled coil core region of the modified silk protein. We used detergent and a protein denaturant to confirm the importance of the helical structure of the silk for heme coordination...
September 4, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29031160/examining-temporal-alterations-in-social-anxiety-disorder-and-posttraumatic-stress-disorder-the-relation-between-autobiographical-memory-future-goals-and-current-self-views
#3
Julie Krans, Manon Peeters, Gérard Näring, Adam D Brown, June de Bree, Agnes van Minnen
The self is a multi-faceted and temporally dynamic construct reflecting representations and beliefs about identity in the past, present, and future. Clinical studies have shown that individuals with Posttraumatic Stress Disorder (PTSD) and Social Anxiety Disorder (SAD) exhibit alterations in self-related processing but these studies have focused primarily on memory. Few studies in PTSD and SAD have examined self-related processing for the present and future, and no studies have directly compared these processes across these two disorders...
October 9, 2017: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/29031152/transferrin-modified-ruthenium-nanoparticles-with-good-biocompatibility-for-photothermal-tumor-therapy
#4
Shuang Zhao, Xufeng Zhu, Chengwen Cao, Jing Sun, Jie Liu
In the past two decades, there were various kinds of photothermal agents being synthesised and investigated for their photothermal effect in antitumor applications. However, it is barely reported that the photothermal effect of Ruthenium (Ru) nanoparticles was researched in depth. In this work, we introduced Ru nanoparticles which possess excellent biocompatibility and metabolize easily to the photothermal therapy field. In addition, to improve the cells capacity of absorbing Ru nanoparticles, these Ru nanoparticles were modified by transferrin (Tf-RuNPs)...
October 7, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29031148/fabrication-of-charge-reversible-graphene-oxide-based-nanocomposite-with-multiple-antibacterial-modes-and-magnetic-recyclability
#5
Qiang Li, Chunyan Yong, Weiwei Cao, Xi Wang, Lina Wang, Jie Zhou, Xiaodong Xing
In this work, N-alkylated poly (4-vinylpyridine) (NPVP), a cationic polymer, was firstly applied for the surface modification of Fe3O4 nanoparticles. Then the modified Fe3O4 nanoparticles (Fe3O4@NPVP NPs) combined with graphene oxide (GO) through simple electrostatic binding. Subsequently, deposited Ag nanoparticles (Ag NPs) procedure was carried out to form the multiple antibacterial nanocomposites (GO-Fe3O4@NPVP-Ag). The synthesized nanostructures were well characterized by Transmission Electron Microscope (TEM), X-ray powder diffraction (XRD), Fourier-transform infrared (FT-IR) and Raman spectroscopy...
October 3, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29031145/small-molecule-mediated-upregulation-of-ccr7-ameliorates-murine-experimental-autoimmune-encephalomyelitis-by-accelerating-t-cell-homing
#6
Xin Li, Tingting Lu, Wenwen Xue, Yixuan Wang, Qiong Luo, Huiming Ge, Renxiang Tan, Yan Shen, Qiang Xu
Impairing the infiltration of immune cells into the CNS is a promising target for suppressing the development of multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). Here, we found that oral administration of a synthetic small molecular compound Fc24 showed potential preventive effects on the development of EAE, including the reduction in EAE severity and a delay in the onset of the disease. Fc24 facilitated the accumulation of both CD4(+) and CD8(+) T cells within spleen and lymph nodes, while having no effect on MOG-specific T cell responses...
October 11, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29031129/a-dual-type-responsive-electrochemical-immunosensor-for-quantitative-detection-of-pcsk9-based-on-n-c60-pdpt-n-gnrs-and-pt-poly-methylene-blue-nanocomposites
#7
Yan Li, Junlin He, Jun Chen, Yazhen Niu, Yilin Zhao, Yuchan Zhang, Chao Yu
In this study, a dual-type responsive electrochemical immunosensor was developed for the quantitative detection of proprotein convertase subtilisin/kexin type 9 (PCSK9), a potential biomarker of cardiovascular disease in serum. N-doped graphene nanoribbons (N-GNRs) with good conductivity were used as the sensing matrix modifying the glassy carbon electrode. Palladium platinum alloy (PdPt) nanoparticles with high catalytic performance toward the reduction of hydrogen peroxide (H2O2) were reduced onto amino-functionalized fullerene (n-C60-PdPt) and significantly amplified the electrochemical signal recorded by the amperometric i-t curve...
September 28, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29031103/kaposi-s-sarcoma-herpesvirus-induced-endothelial-cell-reprogramming-supports-viral-persistence-and-contributes-to-kaposi-s-sarcoma-tumorigenesis
#8
REVIEW
Silvia Gramolelli, Päivi M Ojala
Kaposi's sarcoma (KS) is an endothelial tumor causally linked to Kaposi's sarcoma herpesvirus (KSHV) infection. At early stages of KS, inflammation and aberrant neoangiogenesis are predominant, while at late stages the disease is characterized by the proliferation of KSHV-infected spindle cells (SC). Since KSHV infection modifies the endothelial cell (EC) identity, the origin of SCs remains elusive. Yet, pieces of evidence indicate the lymphatic origin. KSHV-infected ECs display increased proliferative, angiogenic and migratory capacities which account for KS oncogenesis...
October 11, 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/29031091/hexavalent-chromium-removal-by-multilayer-membrane-assisted-by-photocatalytic-couple-nanoparticle-from-both-permeate-and-retentate
#9
Maryamossadat Kazemi, Mohsen Jahanshahi, Majid Peyravi
In this study, a novel photocatalytic thin film nanocomposite (TFC) membrane was prepared for removal of hexavalent chromium (Cr(VI)) from aqueous solution. In this regards, a TFC membrane was modified by a layer of chitosan as an adsorbent and then was coated with a layer of synthesized photocatalytic nanoscale zerovalent iron@titanium dioxide (nZVI@TiO2) nanoparticles via layer-by-layer (LBL) technology. Prepared membranes were characterized by X-ray diffraction (XRD), energy dispersive X-ray spectroscopy (EDX), field emission scanning electron microscopy (FESEM), atomic force microscopy (AFM) and contact angle analysis...
October 3, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29031084/moving-towards-the-benign-automatic-interpretation-bias-modification-in-dysphoria
#10
Alexandra H Cowden Hindash, Jonathan A Rottenberg
Automatic cognitive biases are important to theories of depression and reducing such biases may contribute to therapeutic gains. The present study examined (1) whether it was possible to reduce automatic interpretation biases (AIB) in a single session among dysphoric subjects and (2) whether the effects of modifying AIB generalized to other measures of cognition and emotion. 76 dysphoric students completed a modified semantic association paradigm in which they were randomized to receive active or random-feedback-based training...
September 21, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/29031051/17%C3%AE-estradiol-induces-cyto-genotoxicity-on-blood-cells-of-common-carp-cyprinus-carpio
#11
Luis Orozco-Hernández, Adriana Andrea Gutiérrez-Gómez, Nely SanJuan-Reyes, Hariz Islas-Flores, Sandra García-Medina, Marcela Galar-Martínez, Octavio Dublán-García, Reyna Natividad, Leobardo Manuel Gómez-Oliván
17β-Estradiol, a natural hormone present at high concentrations in aquatic ecosystems, affects and modifies endocrine function in animals. In recent years research workers have expressed concern over its potential effects on aquatic organisms; however, little is known about its capacity to induce genetic damage or the pro-apoptotic effects of such damage on fish. Therefore, this study aimed to evaluate 17β-estradiol-induced cyto-genotoxicity in blood cells of the common carp Cyprinus carpio exposed to different concentrations (1 ng, 1 μg and 1 mg L(-1))...
October 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/29031047/reducing-the-threat-of-wildlife-vehicle-collisions-during-peak-tourism-periods-using-a-roadside-animal-detection-system
#12
Molly K Grace, Daniel J Smith, Reed F Noss
Roadside Animal Detection Systems (RADS) aim to reduce the frequency of wildlife-vehicle collisions. Unlike fencing and wildlife passages, RADS do not attempt to keep animals off the road; rather, they attempt to modify driver behavior by detecting animals near the road and warning drivers with flashing signs. A RADS was installed in Big Cypress National Park (Florida, USA) in 2012 in response to an increased number of Florida panther mortalities. To assess driver response, we measured the speed of individual cars on the road when the RADS was active (flashing) and inactive (not flashing) during the tourist season (November-March) and the off-season (April-October), which vary dramatically in traffic volume...
October 11, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29029375/treatment-and-disease-management-of-multiple-sclerosis-patients-a-review-for-nurse-practitioners
#13
Cortnee Roman, Kara Menning
BACKGROUND AND PURPOSE: This review discusses the role of the nurse practitioner (NP) in evaluating the clinical effects, potential side effects, and monitoring requirements for treatment options in multiple sclerosis (MS) and provides guidance on how to help patients understand these issues. METHODS: A literature search was conducted on PubMed to identify publications on monitoring and disease management of MS patients. Additional resources included drug information web sites and package inserts...
October 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/29029347/childhood-health-and-educational-outcomes-associated-with-maternal-sleep-apnea-a-population-record-linkage-study
#14
Yu Sun Bin, Peter A Cistulli, Christine L Roberts, Jane B Ford
Objectives: Sleep apnea in pregnancy is known to adversely affect birth outcomes. Whether in utero exposure to maternal sleep apnea is associated with long-term childhood consequences is unclear. Methods: Population-based longitudinal study of singleton infants born during 2002 to 2012 was conducted using linked birth, hospital, death, developmental, and educational records from New South Wales, Australia. Maternal sleep apnea during pregnancy was identified from hospital records...
October 5, 2017: Sleep
https://www.readbyqxmd.com/read/29029310/fragrance-allergens-linalool-and-limonene-allylic-hydroperoxides-in-skin-allergy-mechanisms-of-action-focusing-on-transcription-factor-nrf2
#15
Chloé Raffalli, Elodie Clouet, Salen Kuresepi, Marie-Hélène Damiens, Jean-Pierre Lepoittevin, Marc Pallardy, Pierre-Jacques Ferret, Elena Giménez-Arnau, Saadia Kerdine-Römer
Allergic contact dermatitis (ACD) is regarded as the most frequent expression of immunotoxicity in humans. Many odorant terpenes commonly used in fragrance compositions are considered as weak skin sensitizers, whereas some of their autoxidation products, allylic hydroperoxides, are classified as strong sensitizers according to the Local Lymph Node Assay (LLNA). However, the mechanism of their effects on the immune system remains unclear. Since dendritic cells play a key role in ACD, we studied their activation by the frequently used linalool (LINA) and limonene (LIMO), and their respective sensitizing allylic hydroperoxides (LINA-OOH, LIMO-OOH)...
September 29, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29029309/limited-efficacy-of-caffeine-and-recovery-costs-during-and-following-5-days-of-chronic-sleep-restriction-caffeine-and-sleep-restriction
#16
Tracy Jill Doty, Christine J So, Elizabeth M Bergman, Sara K Trach, Ruthie H Ratcliffe, Angela M Yarnell, Vincent F Capaldi, James E Moon, Thomas J Balkin, Phillip J Quartana
Objectives: To investigate the effects of caffeine on psychomotor vigilance and sleepiness during sleep restriction and following subsequent recovery sleep. Methods: Participants were N=48 healthy good sleepers. All participants underwent 5 nights of sleep satiation [time-in-bed (TIB): 10 hrs], followed by 5 nights of sleep restriction (TIB: 5 hrs), and 3 nights of recovery sleep (TIB: 8 hrs) in a sleep laboratory. Caffeine (200 mg) or placebo was administered in the form of chewing gum at 0800 and 1200 hrs each day during the sleep restriction phase...
October 5, 2017: Sleep
https://www.readbyqxmd.com/read/29029272/bsr-and-bhpr-guideline-for-the-prescription-and-monitoring-of-non-biologic-disease-modifying-anti-rheumatic-drugs
#17
Jo Ledingham, Nicola Gullick, Katherine Irving, Rachel Gorodkin, Melissa Aris, Jean Burke, Patrick Gordon, Dimitrios Christidis, Sarah Galloway, Eranga Hayes, Andrew Jeffries, Scott Mercer, Janice Mooney, Sander van Leuven, James Galloway
No abstract text is available yet for this article.
September 28, 2017: Rheumatology
https://www.readbyqxmd.com/read/29029220/effect-of-host-traits-and-land-use-changes-on-the-gut-microbiota-of-the-namibian-black-backed-jackal-canis-mesomelas
#18
Sebastian Menke, Matthias Meier, John K E Mfune, Joerg Melzheimer, Bettina Wachter, Simone Sommer
Host traits and environmental factors drive the natural variation in gut microbiota and disruption in homeostasis can cause infections and chronic diseases. African wildlife is increasingly facing human-induced agricultural habitats, which also amplifies the contact probability with livestock with unknown consequences for wildlife gut microbiotas and the risk of transmission of potentially pathogenic bacteria. We applied high-throughput sequencing of bacterial 16S rRNA genes and microsatellite genotyping to investigate the impact of host traits and habitat use on the gut microbiotas of black-backed jackals (Canis mesomelas)...
September 25, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/29029193/sex-and-iron-modify-fibroblast-growth-factor-23-fgf23-concentration-in-1-year-old-children
#19
Elisa Holmlund-Suila, Maria Enlund-Cerullo, Saara Valkama, Helena Hauta-Alus, Jenni Rosendahl, Otto Helve, Timo Hytinantti, Heli Viljakainen, Sture Andersson, Outi Mäkitie
Context: Fibroblast growth factor 23 (FGF23) plays an important role in phosphate homeostasis but its regulation is inadequately characterized. Objective: To examine regulators of FGF23, especially sex and iron status, in early childhood. Design: A cross-sectional study involving 1-year-old children. Setting and participants: Healthy term infants with a birth weight appropriate for gestational age were recruited to an ongoing vitamin D trial at the Kätilöopisto Maternity Hospital, Helsinki, Finland...
October 5, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29029170/use-of-a-structured-panel-process-to-define-antimicrobial-prescribing-appropriateness-in-critical-care
#20
Linda D Dresser, Chaim M Bell, Marilyn Steinberg, Niall D Ferguson, Stephen Lapinsky, Neil Lazar, Patricia Murphy, Jeffrey M Singh, Andrew M Morris
Background: Antimicrobial prescribing is frequently reported as appropriate or inappropriate, particularly in the ICU. However, the definitions used are non-standardized and lack validity and reliability. Objectives: To develop standardized definitions of appropriateness for antimicrobial prescribing in the critical care setting. Methods: We used consensus-based modified Delphi and RAND appropriateness methodology to develop criteria to define appropriateness of antimicrobial prescribing...
September 26, 2017: Journal of Antimicrobial Chemotherapy
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