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https://www.readbyqxmd.com/read/29475213/modified-multivisceral-transplantation-with-native-spleen-removal-in-rats
#1
Pablo Stringa, Nidia Monserrat Arreola, Ane M Andres Moreno, Carlota Largo, Martín Rumbo, Francisco Hernandez
BACKGROUND:  Modified multivisceral transplantation (MMVTx) refers to the use of a graft that includes all abdominal organs except the liver. The use of this type of transplant in children and adults expanded over the last years with good results. However, long-term survival in experimental models has not been reported. Our aim is to describe in detail some technical modifications of MMVTx to obtain long-term survival. MATERIALS AND METHODS:  Syngeneic (Lewis-Lewis) heterotopic MMVTx was performed in 16 male rats (180-250 g)...
February 23, 2018: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29475211/preoperative-care-of-the-tka-patient
#2
Paul K Edwards, Simon C Mears, C Lowry Barnes
Total knee arthroplasty continues to increase in popularity and remains the most common joint replacement surgery. The success of total knee replacement surgery is attributed to improved outcomes, a better patient experience, and lower cost. Rapid recovery total knee replacement protocols have led to these advances by decreasing length of hospital stay, minimizing readmissions, and reducing the cost of surgery. Rapid recovery total knee replacement pathway efforts should focus on preoperative education, optimization of modifiable risk factors, and identification of patients that may not be suitable for this pathway...
February 23, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29475204/time-frequency-features-for-impedance-cardiography-signals-during-anesthesia-using-different-distribution-kernels
#3
Jesús Escrivá Muñoz, Pedro Gambús, Erik W Jensen, Montserrat Vallverdú
OBJECTIVE: This works investigates the time-frequency content of impedance cardiography signals during a propofol-remifentanil anesthesia. MATERIALS AND METHODS: In the last years, impedance cardiography (ICG) is a technique which has gained much attention. However, ICG signals need further investigation. Time-Frequency Distributions (TFDs) with 5 different kernels are used in order to analyze impedance cardiography signals (ICG) before the start of the anesthesia and after the loss of consciousness...
January 2018: Methods of Information in Medicine
https://www.readbyqxmd.com/read/29475183/the-role-of-dimethyl-sulfoxide-dmso-in-ex-vivo-examination-of-human-skin-burn-injury-treatment
#4
Anna Pielesz, Andrzej Gawłowski, Dorota Biniaś, Rafał Bobiński, Marek Kawecki, Agnieszka Klama-Baryła, Diana Kitala, Wojciech Łabuś, Justyna Glik, Jadwiga Paluch
Dimethyl sulfoxide (DMSO) is one of the most versatile solvents in biological science, therefore it is frequently used as a solvent in biological studies and as a vehicle for drug therapy. DMSO readily penetrates, diffuses through biological membranes and ipso facto increases fluidity of liposomal membranes modelling stratum corneum. Thermal injury is associated with the appearance of lipid peroxidation products in the burned skin. The influence of DMSO on protein structure and stability is concentration and temperature dependant...
February 13, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29475152/relationship-between-rearfoot-tibia-and-femur-kinematics-in-runners-with-and-without-patellofemoral-pain
#5
Bruna Calazans Luz, Ana Flávia Dos Santos, Mariana Carvalho de Souza, Tatiana de Oliveira Sato, Deborah A Nawoczenski, Fábio Viadanna Serrão
BACKGROUND: Patellofemoral pain (PFP) is the most common running overuse injury. Excessive rearfoot eversion is commonly considered as a PFP risk factor and the relationship between ankle-foot complex movement and lower limb may be involved with this dysfunction. The purpose of this study was to evaluate the correlation between rearfoot eversion with tibia and femur kinematics in frontal and transverse planes during running in individuals with and without PFP. The secondary purpose was to compare the lower limb kinematics between runners with and without PFP...
February 12, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29475126/snp-rs403212791-in-exon-2-of-the-mtnr1a-gene-is-associated-with-reproductive-seasonality-in-the-rasa-aragonesa-sheep-breed
#6
J H Calvo, M Serrano, A Martinez-Royo, B Lahoz, P Sarto, A Ibañez-Deler, J Folch, J L Alabart
The aim of this study was to characterize and identify causative SNPs in the MTNR1A gene responsible for the reproductive seasonality traits in the Rasa aragonesa sheep breed. A total of 290 ewes (155, 84 and 51 mature, young and ewe lambs, respectively) from one flock were controlled from January to August. The following three reproductive seasonality traits were considered: the total days of anoestrus (TDA) and the progesterone cycling months (P4CM); both ovarian function seasonality traits based on blood progesterone levels; and the oestrus cycling months (OCM) based on oestrous detection, which indicate behavioural signs of oestrous...
February 12, 2018: Theriogenology
https://www.readbyqxmd.com/read/29475074/stapled-truncated-orexin-peptides-as-orexin-receptor-agonists
#7
Lasse Karhu, Janne Weisell, Pauli M Turunen, Teppo O Leino, Henri Pätsi, Henri Xhaard, Jyrki P Kukkonen, Erik A A Wallén
The peptides orexin-A and -B, the endogenous agonists of the orexin receptors, have similar 19-amino-acid C-termini which retain full maximum response as truncated peptides with only marginally reduced potency, while further N-terminal truncations successively reduce the activity. The peptides have been suggested to bind in an α-helical conformation, and truncation beyond a certain critical length is likely to disrupt the overall helical structure. In this study, we set out to stabilize the α-helical conformation of orexin-A15-33 via peptide stapling at four different sites...
February 20, 2018: Peptides
https://www.readbyqxmd.com/read/29475019/diastolic-blood-pressure-is-a-potentially-modifiable-risk-factor-for-preeclampsia-in-women-with-pre-existing-diabetes
#8
Sidse Kjærhus Nørgaard, Marianne Jenlev Vestgaard, Isabella Lindegaard Jørgensen, Björg Ásbjörnsdóttir, Lene Ringholm, Harold David McIntyre, Peter Damm, Elisabeth Reinhardt Mathiesen
AIMS: To identify early clinical, modifiable risk factors for preeclampsia present at first antenatal visit and assess the prevalence of pregnancy-related hypertensive disorders in women with pre-existing diabetes treated with tight glycemic and blood pressure (BP) control. METHODS: A population-based cohort study of 494 women with pre-existing diabetes (307 and 187 women with type 1 and type 2 diabetes, respectively), included at their first antenatal visit from 2012-16...
February 20, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29474995/evaluation-of-performance-based-outcome-measures-for-the-upper-limb-a-comprehensive-narrative-review
#9
REVIEW
Sophie Wang, Janice Hsu, Lauren Trent, Tiffany Ryan, Nathan Kearns, Eugene Civillico, Kimberly Kontson
Objective performance-based outcome measures (OMs) have the potential to provide unbiased and reproducible assessments of limb function. However, very few of these performance-based OMs have been validated for upper limb (UL) prosthesis users. OMs validated in other clinical populations (e.g. neurological or musculoskeletal conditions) could be used to fill gaps in existing performance-based OMs for UL amputees. Additionally, a joint review might reveal consistent gaps across multiple clinical populations. Therefore, the objective of this review was to systematically characterize prominent measures utilized in both sets of clinical populations with regard to (1) location of task performance around the body, (2) possible grips employed, (3) bilateral vs...
February 20, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29474933/an-optimised-multi-arm-multi-stage-clinical-trial-design-for-unknown-variance
#10
Michael J Grayling, James M S Wason, Adrian P Mander
Multi-arm multi-stage trial designs can bring notable gains in efficiency to the drug development process. However, for normally distributed endpoints, the determination of a design typically depends on the assumption that the patient variance in response is known. In practice, this will not usually be the case. To allow for unknown variance, previous research explored the performance of t-test statistics, coupled with a quantile substitution procedure for modifying the stopping boundaries, at controlling the familywise error-rate to the nominal level...
February 20, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29474898/doe-based-olanzapine-loaded-poly-caprolactone-nanoparticles-decreases-extrapyramidal-effects-in-rodent-model
#11
Emil Joseph, Satish Reddi, Vibhu Rinwa, Garima Balwani, Ranendra Saha
The purpose of present investigation was to nano-encapsulate atypical antipsychotic such as Olanzapine in polymeric nanoparticles in order to explore the possibility of minimizing drug associated extrapyramidal adverse effects. The polymeric nanoparticulate systems were prepared using FDA approved polymer, polycaprolactone, by simple technique of nanoprecipitation using factorial design by DoE approach. The significant factors selected for the optimization during formulation development process were polymer content and surfactant concentration at three different levels (32 factorial design)...
February 20, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29474892/eeg-frequency-tagging-reveals-higher-order-intermodulation-components-as-neural-markers-of-learned-holistic-shape-representations
#12
Mark Vergeer, Naoki Kogo, Andrey R Nikolaev, Nihan Alp, Veerle Loozen, Brenda Schraepen, Johan Wagemans
Shape perception is intrinsically holistic: combinations of features give rise to configurations with emergent properties that are different from the sum of the parts. The current study investigated neural markers of holistic shape representations learned by means of categorization training. We used the EEG frequency tagging technique, where two parts of a shape stimulus were 'tagged' by modifying their contrast at different temporal frequencies. Signals from both parts are integrated and, as a result, emergent frequency components (so-called, intermodulation responses, IMs), caused by nonlinear interaction of two frequency signals, are observed in the EEG spectrum...
February 20, 2018: Vision Research
https://www.readbyqxmd.com/read/29474882/the-angiographic-and-clinical-outcomes-of-intracranial-aneurysms-following-irradiation-in-patients-with-nasopharyngeal-carcinoma-a-13-year-experience-and-literature-review
#13
Chan Siang Hua Victor, Woo Yat Ming Peter, Wong Kai Sing Alain, Chan Kwong Yau, Leung Kar Ming
BACKGROUND AND PURPOSE: Intracranial aneurysms are a known but rare complication of radiotherapy (RT). We reviewed the angiographic and clinical outcomes of intracranial aneurysms following RT in patients with nasopharyngeal carcinoma (NPC), a malignancy endemic in Hong Kong. MATERIALS AND METHODS: The clinical, angiographic and laboratory data was collected for nine NPC patients harboring fifteen intracranial aneurysms following RT, diagnosed between 1st January 2000 and 31st December 2012...
February 20, 2018: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/29474860/pharmacological-targeting-of-the-mammalian-clock-reveals-a-novel-analgesic-for-osteoarthritis-induced-pain
#14
Vaskar Das, Ranjan Kc, Xin Li, Disha Varma, Sujun Qiu, Jeffrey S Kroin, Christopher B Forsyth, Ali Keshavarzian, Andre J van Wijnen, Thomas J Park, Gary S Stein, Insug O-Sullivan, Thomas P Burris, Hee-Jeong Im
Environmental disruption of the circadian rhythm is linked with increased pain due to osteoarthritis (OA). We aimed to characterize the role of the clock gene in OA-induced pain more systemically using both genetic and pharmacological approaches. Genetically modified mice, (bmal1f/fNav1.8CreERT mice), generated by deleting the critical clock gene, bmal1, from Nav1.8 sensory neurons, were resistant to the development of mechanical hyperalgesia associated with OA induced by partial medial meniscectomy (PMM) of the knee...
February 20, 2018: Gene
https://www.readbyqxmd.com/read/29474838/time-allocation-and-dietary-habits-in-the-united-states-time-for-re-evaluation
#15
Barbara H Fiese
In this non-exhaustive narrative review, time allocation and its relation to dietary habits are discussed. Drawing from reports relying on time use surveys, the amount of time dedicated to cooking and dining is found to be associated with health outcomes such as BMI and cardiovascular risk. Important modifiers include gender, race, ethnicity and household income. Perception of time intensity is also discussed. Individuals who perceive time pressure or strain may be less likely to engage in healthy food related activities and be at greater risk for poor health outcomes...
February 20, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29474835/development-of-a-new-screening-method-to-determine-the-main-52-mitochondrial-haplogroups-through-a-single-minisequencing-reaction
#16
Leire Palencia-Madrid, Sergio Cardoso, Fernando Castro-Maestre, Igor Baroja-Careaga, Ana M Rocandio, Marian M de Pancorbo
This work presents the design, development and optimization of a screening method based on single-base extension sequencing to simultaneously analyze a panel of 52 mitochondrial SNPs. This enables to recognize the main mitochondrial haplogroups and to discriminate even between lineages from the same phylogenetic branch that diverged in different continents. The unavailability of individuals harboring infrequent variants was a limitation to optimize the panel. To overcome this, we have modified DNA by site-directed mutagenesis to create the unavailable allelic variants...
February 20, 2018: Mitochondrion
https://www.readbyqxmd.com/read/29474725/thermal-stability-of-laser-induced-modified-volumes-in-si-as-studied-by-in-situ-and-ex-situ-heating-experiments
#17
Hiroyasu Saka, Hiroyuki Iwata, Daisuke Kawaguchi
Radiation of a permeable laser beam into Si induces considerable modification of structures. Thermal stability of the laser-induced modified volumes (LIMV's) was studied comprehensively by means of in situ and ex situ heating experiments using transmission electron microscopy. The behavior in the tail region of a LIMV can be understood by dislocation theory, while that of a void formed at the very focus of a laser beam cannot be understood easily.
February 21, 2018: Microscopy
https://www.readbyqxmd.com/read/29474709/affinity-maturation-of-an-tpor-targeting-antibody-in-full-length-igg-form-for-enhanced-agonist-activity
#18
Zhuo Yang, Mingjuan Du, Wei Wang, Xiu Xin, Peixiang Ma, Hongkai Zhang, Richard A Lerner
It has been observed that converting scFv formatted antibodies to full-length IgG often associates with loss of affinity. We aim to address this issue in this paper by establishing an integrated affinity maturation method applying yeast display technology platform. To demonstrate that, we employed a human thrombopoietin receptor targeting antibody named 3D9 which was identified previously from a combinational antibody library in scFv-Fc fusion protein form. We have observed that significant potency loss happened when 3D9 was transformed to full-length IgG form...
February 21, 2018: Protein Engineering, Design & Selection: PEDS
https://www.readbyqxmd.com/read/29474695/age-differences-in-beliefs-about-emotion-regulation-strategies
#19
Kimberly M Livingstone, Vanessa L Castro, Derek M Isaacowitz
Objectives: Age shifts in emotion regulation may be rooted in beliefs about different strategies. We test whether there are age differences in the beliefs people hold about specific emotion regulation strategies (derived from the process model of emotion regulation: Gross, 1998) and whether profiles of emotion beliefs vary by age. Method: An adult lifespan sample (N = 557) sorted 13 emotion regulation strategies either by (a) how effective the strategies would be or (b) how likely they would be to use them, in 15 negative emotion-eliciting situations...
February 21, 2018: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/29474493/construction-and-characterization-of-bacterial-artificial-chromosomes-harboring-the-full-length-genome-of-a-highly-attenuated-vaccinia-virus-lc16m8
#20
Tomoki Yoshikawa, Hikaru Fujii, Akiko Okutani, Miho Shibamura, Natsumi Omura, Kazutaka Egawa, Hirofumi Kato, Takuya Inagaki, Shizuko Harada, Souichi Yamada, Shigeru Morikawa, Masayuki Saijo
LC16m8 (m8), a highly attenuated vaccinia virus (VAC) strain, was developed as a smallpox vaccine, and its safety and immunogenicity have been confirmed. Here, we aimed to develop a system that recovers infectious m8 from a bacterial artificial chromosome (BAC) that retains the full-length viral genomic DNA (m8-BAC system). The infectious virus was successfully recovered from a VAC-BAC plasmid, named pLC16m8-BAC. Furthermore, the bacterial replicon-free virus was generated by intramolecular homologous recombination and was successfully recovered from a modified VAC-BAC plasmid, named pLC16m8...
2018: PloS One
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