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Michael John Kerins, John Milligan, James Akira Wohlschlegel, Aikseng Ooi
Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a hereditary cancer syndrome characterized by inactivation of the Krebs cycle enzyme fumarate hydratase (FH). HLRCC patients are at a high risk of developing kidney cancer of type 2 papillary morphology that is refractory to current radio-, immuno-, and chemo- therapies. Hence, an effective therapy for this deadly form of cancer is urgently needed. Here we show that FH inactivation (FH-/- ) proves synthetic lethal with inducers of ferroptosis, an iron-dependent and nonapoptotic form of cell death...
June 19, 2018: Cancer Science
Manda Curic, Marina Juribašić Kulcar, Alen Bjelopetrović, Stipe Lukin, Ivan Halasz, Krunoslav Užarević, Ivica Đilović, Dajana Barišić, Ana Budimir
Mechanism of C-H bond activation by various Pd(II) catalysts under milling conditions has been studied by in situ Raman spectroscopy. Common Pd(II) precursors, i.e. PdCl₂, [Pd(OAc)₂]₃, PdCl₂(MeCN)₂ and [Pd(MeCN)₄][BF₄]₂, have been employed for the activation of one or two C-H bonds in an unsymmetrical azobenzene substrate. The C-H activation was achieved by all used Pd(II) precursors and their reactivity increases in the order [Pd(OAc)₂]₂ < PdCl₂(MeCN)₂ < PdCl₂ < [Pd(MeCN)₂][BF₄]₂...
June 19, 2018: Chemistry: a European Journal
J-Y Pan, R-X Cai, Y Chen, Y Li, W-W Lin, J Wu, X-D Wang
OBJECTIVE: To investigate the effects of hyperbaric oxygen preconditioning (HBO-PC) on neuronal apoptosis, Ca2+ concentration, and Caspases expression after spinal cord injury (SCI) in rats. MATERIALS AND METHODS: A total of 36 rats were randomly divided into control group (CON group), hyperbaric oxygen preconditioning group (HBO-PC group) and spinal cord injury group (SCI group), with 12 rats in each group. Rats in group HBO-PC were given HBO-PC intervention before modeling...
June 2018: European Review for Medical and Pharmacological Sciences
M A Bakhrebah, M S Nassar, M S Alsuabeyl, W A Zaher, S A Meo
OBJECTIVE: Infectious diseases are one of the prime causes of death worldwide. An innovative sequence specific editing technology "Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)" has been tested on a broad range of microorganisms to target and destroy invading foreign DNA to human cells or tissues. This study aimed to discuss the mechanism and therapeutic usage of CRISPR/Cas9 genome editing technology in the management of various infectious disease pathogens...
June 2018: European Review for Medical and Pharmacological Sciences
Xiaowei Diao, Xiubin Chen, Yurui Pi, Yu Zhang, Fangfang Wang, Ping Liu, Yanhong Gao, Xiaojun Wang, Sijun Yang, Shan Lu
Erythropoietin‑producing hepatocellular carcinoma cell surface type‑A receptor 3 (EPHA3) has been found to promote the proliferation and survival of prostate cancer (PCa) cell lines and prostate tumor development in nude mice. However, the regulation of EPHA3 in PCa remains largely unknown. This study is aimed to investigate the association between EPHA3 expression and androgen receptor (AR) signaling and the potential mechanism. We determined mRNA and protein levels of EPHA3 and AR signaling‑related genes in the PCa cell line 22Rv1 by reverse transcription‑polymerase chain reaction (RT‑PCR) and western blotting, respectively...
June 18, 2018: Oncology Reports
Xiaoqing Liu, Suzhen Li, Wenzhu Yang, Bona Mu, Yong Jiao, Xiaojin Zhou, Chunyi Zhang, Yunliu Fan, Rumei Chen
Tissue-specific promoters play an important role in plant molecular farming. Here, we describe a strategy to modify the tissue specificity of a maize embryo-specific bidirectional promoter PZmBD1. Six types of cis elements: RY repeats (R), GCN4 (G), the prolamin box (P), Skn-1 (S), and the ACGT and AACA (A) motifs, were collected and fused to PZmBD1 to generate eight chimeric putative bidirectional promoters. Qualitative and quantitative analysis of reporter genes driven by the promoters showed that two promoters exhibited high seed-specific bidirectional activity in maize transient and stable transformed system...
June 15, 2018: Plant & Cell Physiology
Monica S M Persson, Aliya Sarmanova, Michael Doherty, Weiya Zhang
Objectives: The role of inflammation in OA is controversial and it is unclear whether suppressing inflammation with conventional or biologic DMARDs is effective. A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to compare DMARDs with placebo in participants with symptomatic OA. Methods: Databases (Medline, Embase, Allied and Complementary Medicine Database, Web of Science and Cochrane Library), conference abstracts and ClinicalTrials...
June 16, 2018: Rheumatology
Kathleen A Garrison, Prasanta Pal, Stephanie S O'Malley, Brian P Pittman, Ralitza Gueorguieva, Rahil Rojiani, Dustin Scheinost, Jesse Dallery, Judson A Brewer
Introduction: Mindfulness training may reduce smoking rates and lessen the association between craving and smoking. This trial tested the efficacy of mindfulness training via smartphone app to reduce smoking. Experience sampling was used to measure real time craving, smoking and mindfulness. Methods: A researcher-blind, parallel randomized controlled trial compared the efficacy of mobile mindfulness training with experience sampling (MMT-ES; Craving to Quit) vs...
June 18, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
Carmen Campino, Rene Baudrand, Carolina Valdivia, Cristian Carvajal, Andrea Vecchiola, Alejandra Tapia-Castillo, Alejandro Martínez-Aguayo, Hernán Garcia, Lorena García, Fidel Allende, Sandra Solari, Cristóbal Fuentes, Calos F Lagos, Maria Paulina Rojas, Doris Muñoz, Carlos Fardella
Background: Mounting evidence has associated high sodium intake with hypertension, cardiovascular disease and stroke. We investigated whether high sodium intake modulates the parameters of endothelial damage, inflammation and oxidative stress. Methods: We used a cross-sectional study design including 223 Chilean subjects (6.9-65.0 years old). We measured aldosterone, renin activity, cortisol, cortisone, adiponectin, leptin, hs-CRP, IL-6, TNF-alpha, PAI-1, metalloproteinase (MMP)-9 and MMP-2 activity and malondialdehyde (MDA)...
June 16, 2018: American Journal of Hypertension
Benjamin Woodhams, Laura Ansel-Bollepalli, Jakub Surmacki, Helena Knowles, Laura Maggini, Michael de Volder, Mete Atatüre, Sarah Bohndiek
Nanodiamonds have demonstrated potential as powerful sensors in biomedicine, however, their translation into routine use requires a comprehensive understanding of their effect on the biological system being interrogated. Under normal fabrication processes, nanodiamonds are produced with a graphitic carbon shell, but are often oxidized in order to modify their surface chemistry for targeting to specific cellular compartments. Here, we assessed the biological impact of this purification process, considering cellular proliferation, uptake, and oxidative stress for graphitic and oxidized nanodiamond surfaces...
June 19, 2018: Nanoscale
Qiang Zhang, Xiang Yao, Zhen Wang
No abstract text is available yet for this article.
April 2018: VideoGIE: an official video journal of the American Society for Gastrointestinal Endoscopy
Callum J Court, Jacqueline M Cole
Large auto-generated databases of magnetic materials properties have the potential for great utility in materials science research. This article presents an auto-generated database of 39,822 records containing chemical compounds and their associated Curie and Néel magnetic phase transition temperatures. The database was produced using natural language processing and semi-supervised quaternary relationship extraction, applied to a corpus of 68,078 chemistry and physics articles. Evaluation of the database shows an estimated overall precision of 73%...
June 19, 2018: Scientific Data
Stephanie Tullo, Gabriel A Devenyi, Raihaan Patel, Min Tae M Park, D Louis Collins, M Mallar Chakravarty
Previous work from our group demonstrated the use of multiple input atlases to a modified multi-atlas framework (MAGeT-Brain) to improve subject-based segmentation accuracy. Currently, segmentation of the striatum, globus pallidus and thalamus are generated from a single high-resolution and -contrast MRI atlas derived from annotated serial histological sections. Here, we warp this atlas to five high-resolution MRI templates to create five de novo atlases. The overall goal of this work is to use these newly warped atlases as input to MAGeT-Brain in an effort to consolidate and improve the workflow presented in previous manuscripts from our group, allowing for simultaneous multi-structure segmentation...
June 19, 2018: Scientific Data
Cynthia Chen, Neil Kaushal, David M Scher, Shevaun M Doyle, John S Blanco, Emily R Dodwell
BACKGROUND: Clubfoot is a common congenital anomaly with multiple potential risk factors. Identification of modifiable risk factors may minimize future incidence of clubfoot. The aim of this meta-analysis was to systematically review and analyze the best clinical evidence regarding risk factors associated with clubfoot. METHODS: Medline, Embase, and Cochrane databases were systematically searched from 1967 to May 11, 2016 for studies reporting risk factors for clubfoot...
June 18, 2018: Journal of Pediatric Orthopedics
Héctor-Omar Malagón-Hidalgo, Roberto Vilchis-López, Diego-Raúl González-Chapa, Richael-Antonio Silva-Suárez, Eugenio García-Cano, José-Luis Lastiri-Barrios, Fernando González-Magaña
INTRODUCTION: The LeFort II osteotomy has a specific number of indications, thus this is true, there is less experience with the technique. The authors present a modification to the technique and extensive step-by-step procedure explanation in order to share their experience for making a safe surgery. MATERIAL AND METHODS: A clinical report is presented of a nonsyndromatic patient with nasomaxillary hypoplasia, in which the authors make an LeFort II osteotomy with circumvestibular, transcaruncular, and "W"-shaped approaches, with minimal scar showing, in order to offer better aesthetic outcomes as well as functional and skeletal...
June 18, 2018: Journal of Craniofacial Surgery
Andrew M Simpson, Sagar T Mehta, Faizi Siddiqi, Duane Yamashiro, Barbu Gociman
The surgical management of midface hypoplasia in the setting of Nager syndrome remains a significant challenge for craniofacial surgeons. This study describes a novel technique using distraction osteogenesis and modified osteotomies for the treatment of midface bony defects in an 11-year-old child with Nager syndrome.Presurgical 3-dimensional planning was performed to design the osteotomies and placement of distractors. The surgical approach required upper buccal sulcus and extended transconjunctival incisions only...
June 18, 2018: Journal of Craniofacial Surgery
Nicole G Campos, Naomi Lince-Deroche, Carla J Chibwesha, Cynthia Firnhaber, Jennifer S Smith, Pam Michelow, Gesine Meyer-Rath, Lise Jamieson, Suzette Jordaan, Monisha Sharma, Catherine Regan, Stephen Sy, Gui Liu, Vivien Tsu, Jose Jeronimo, Jane J Kim
BACKGROUND: Women with HIV face an increased risk of human papillomavirus (HPV) acquisition and persistence, cervical intraepithelial neoplasia, and invasive cervical cancer. Our objective was to determine the cost-effectiveness of different cervical cancer screening strategies among women with HIV in South Africa. METHODS: We modified a mathematical model of HPV infection and cervical disease to reflect co-infection with HIV. The model was calibrated to epidemiologic data from HIV-infected women in South Africa...
June 15, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
James R Berstock, Andrew D Beswick, José A López-López, Michael R Whitehouse, Ashley W Blom
BACKGROUND: The capacity for total knee arthroplasty to improve pain, quality of life, and functional outcomes is widely recognized. Postoperative mortality is rare but of paramount importance, and needs to be accurately quantified and conveyed to patients in order to support decision-making prior to surgery. The purpose of this study was to determine a contemporary estimate of the risk of mortality following total knee arthroplasty, including the identification of temporal trends, common causes, and modifiable and nonmodifiable risk factors...
June 20, 2018: Journal of Bone and Joint Surgery. American Volume
Ulrich E Ziegler, Udo Lorenz, Adrien Daigeler, Selina N Ziegler, Philip H Zeplin
BACKGROUND: Pseudogynecomastia is the increased aggregation of fatty tissue in the area of the male breast with resultant female appearance. Two forms can appear: pseudogynecomastia after massive weight loss (pseudogynecomastia obese [PO]) and pseudogynecomastia, which is caused only by adipose tissue (pseudogynecomastia fat). For PO, only the Gusenoff classification with corresponding operative treatment options exists. However, this classification is limited by the fact that it underestimates the extensive variability of residual fat tissue and skin excess, both crucial factors for operative planning...
June 19, 2018: Annals of Plastic Surgery
Kevin J Zuo, Helene Retrouvey, Kyle R Wanzel
OBJECTIVE: Securing a residency training position in plastic surgery is highly competitive each year with a limited quota of positions and numerous qualified applicants. Although previous studies have highlighted the importance of residency programs and applicants seeking a "good fit," it remains poorly understood what influences a medical student's impression and desire to train at a certain program over others. The objective of this cross-sectional study was to identify which specific potentially modifiable factors during elective rotations and program interviews were most important to Canadian medical students when ranking plastic surgery programs...
June 19, 2018: Annals of Plastic Surgery
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