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https://www.readbyqxmd.com/read/29457738/reproducibility-and-feasibility-of-strategies-for-morphologic-assessment-of-renal-biopsies-using-the-nephrotic-syndrome-study-network-digital-pathology-scoring-system
#1
Jarcy Zee, Jeffrey B Hodgin, Laura H Mariani, Joseph P Gaut, Matthew B Palmer, Serena M Bagnasco, Avi Z Rosenberg, Stephen M Hewitt, Lawrence B Holzman, Brenda W Gillespie, Laura Barisoni
CONTEXT: - Testing reproducibility is critical for the development of methodologies for morphologic assessment. Our previous study using the descriptor-based Nephrotic Syndrome Study Network Digital Pathology Scoring System (NDPSS) on glomerular images revealed variable reproducibility. OBJECTIVE: - To test reproducibility and feasibility of alternative scoring strategies for digital morphologic assessment of glomeruli and explore use of alternative agreement statistics...
February 19, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29456433/the-pillars-of-prevention-discover-advocate-and-educate
#2
Brenda Montgomery
EDITOR'S NOTE: This article is adapted from a speech that Ms. Montgomery delivered as the American Diabetes Association's President of Health Care & Education at ADA's Annual Meeting and Scientific Sessions in June 2017, San Diego, Calif. A webcast of the speech can be viewed on ADA's DiabetesPro website at https://professional.diabetes.org/webcasts-ss2017.
February 2018: Diabetes Spectrum: a Publication of the American Diabetes Association
https://www.readbyqxmd.com/read/29456052/performance-of-a-highly-successful-outbreak-strain-of-mycobacterium-tuberculosis-in-a-multifaceted-approach-to-bacterial-fitness-assessment
#3
Noemí Yokobori, Beatriz López, Johana Monteserin, Roxana Paul, Andrea Von Groll, Anandi Martin, Brenda Marquina-Castillo, Juan Carlos Palomino, Rogelio Hernández-Pando, María Del Carmen Sasiain, Viviana Ritacco
Determining bacterial fitness represents a major challenge and no single parameter can accurately predict the ability of a certain pathogen to succeed. The M strain of Mycobacterium tuberculosis managed to spread and establish in the community and caused the largest multidrug-resistant tuberculosis outbreak in Latin America. We have previously shown that the M strain can manipulate the host immune response, but we still have no direct evidence, other than epidemiology, that can account for the enhanced fitness of the M strain...
January 31, 2018: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/29454927/syndemics-among-individuals-enrolled-in-the-prep-brasil-study
#4
Raquel B De Boni, Iona K Machado, Mauricio T L De Vasconcellos, Brenda Hoagland, Esper G Kallas, José Valdez Madruga, Nilo M Fernandes, Natalia B Cerqueira, Ronaldo I Moreira, Silvia P Goulart, Valdilea G Veloso, Beatriz Grinsztejn, Paula M Luz
BACKGROUND: Concurrent psychosocial problems may synergistically increase the risk of HIV infection (syndemics), representing a challenge for prevention. We aimed to evaluate the prevalence and associated factors of syndemics among men who have sex with men (MSM) and transgender women (TGW) enrolled in the Brazilian pre-exposure prophylaxis demonstration study (PrEP Brasil Study). METHODS: Secondary cross-sectional analysis of the PrEP Brasil Study was performed...
February 10, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29453413/depression-and-obesity-evidence-of-shared-biological-mechanisms
#5
REVIEW
Yuri Milaneschi, W Kyle Simmons, Elisabeth F C van Rossum, Brenda Wjh Penninx
Depression and obesity are common conditions with major public health implications that tend to co-occur within individuals. The relationship between these conditions is bidirectional: the presence of one increases the risk for developing the other. It has thus become crucial to gain a better understanding of the mechanisms responsible for the intertwined downward physiological spirals associated with both conditions. The present review focuses specifically on shared biological pathways that may mechanistically explain the depression-obesity link, including genetics, alterations in systems involved in homeostatic adjustments (HPA axis, immuno-inflammatory activation, neuroendocrine regulators of energy metabolism including leptin and insulin, and microbiome) and brain circuitries integrating homeostatic and mood regulatory responses...
February 16, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29450603/a-wandering-spleen
#6
REVIEW
Pengcheng Zhang, Raymond B Dyer, Brenda L Holbert
No abstract text is available yet for this article.
February 15, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29449496/patient-reported-outcomes-resource-use-and-social-participation-of-patients-with-rheumatoid-arthritis-treated-with-biologics-in-alberta-experience-of-indigenous-and-non-indigenous-patients
#7
Cheryl Barnabe, Louise Crane, Tyler White, Brenda Hemmelgarn, Gilaad G Kaplan, Liam Martin, Walter P Maksymowych
OBJECTIVE: To characterize patient-reported outcomes, resource use, and social participation during the course of biologic therapy for indigenous and non-indigenous patients with rheumatoid arthritis (RA). METHODS: Patients initiating biologic therapy (2004 to 2012) were characterized longitudinally for patient-reported outcomes including physical function measured by the Health Assessment Questionnaire, EQ-5D, well-being [Medical Outcomes Study Short Form-36 (SF-36)], and visual analog scales for pain, fatigue, sleep, stiffness, and patient's global assessment...
February 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29449380/annotated-genome-sequences-of-16-lineage-4-mycobacterium-tuberculosis-strains-from-guatemala
#8
Joseph W Saelens, Dalia Lau-Bonilla, Anneliese Moller, Ana M Xet-Mull, Narda Medina, Brenda Guzmán, Maylena Calderón, Raúl Herrera, Jason E Stout, Eduardo Arathoon, Blanca Samayoa, David M Tobin
Whole-genome sequencing has resulted in new insights into the phylogeography of Mycobacterium tuberculosis However, only limited genomic data are available from M. tuberculosis strains in Guatemala. Here we report 16 complete genomes of clinical strains belonging to the Euro-American lineage 4, the most common lineage found in Guatemala and Central America.
February 15, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29449291/adapting-and-enhancing-pax-good-behavior-game-for-first-nations-communities-a-mixed-methods-study-protocol-developed-with-swampy-cree-tribal-council-communities-in-manitoba
#9
Janique Fortier, Mariette Chartier, Sarah Turner, Nora Murdock, Frank Turner, Jitender Sareen, Tracie O Afifi, Laurence Y Katz, Marni Brownell, James Bolton, Brenda Elias, Corinne Isaak, Roberta Woodgate, Depeng Jiang
INTRODUCTION: High rates of mental health problems, such as suicidal behaviours, among First Nations youth in Canada are a major public health concern. The Good Behavior Game (GBG) is a school-based intervention that provides a nurturing environment for children and has been shown to promote positive outcomes. PAX Good Behavior Game (PAX GBG) is an adaptation and enhancement of the GBG. While PAX GBG has been implemented in Indigenous communities, little research exists examining the cultural and contextual appropriateness and effectiveness of the intervention in First Nations communities...
February 15, 2018: BMJ Open
https://www.readbyqxmd.com/read/29449073/healthy-minds-0-100-years-optimising-the-use-of-european-brain-imaging-cohorts-lifebrain
#10
Kristine B Walhovd, Anders M Fjell, René Westerhausen, Lars Nyberg, Klaus P Ebmeier, Ulman Lindenberger, David Bartrés-Faz, William F C Baaré, Hartwig R Siebner, Richard Henson, Christian A Drevon, Gun Peggy Strømstad Knudsen, Isabelle Budin Ljøsne, Brenda W J H Penninx, Paolo Ghisletta, Ole Rogeberg, Lorraine Tyler, Lars Bertram
The main objective of "Lifebrain" is to identify the determinants of brain, cognitive and mental (BCM) health at different stages of life. By integrating, harmonising and enriching major European neuroimaging studies across the life span, we will merge fine-grained BCM health measures of more than 5000 individuals. Longitudinal brain imaging, genetic and health data are available for a major part, as well as cognitive and mental health measures for the broader cohorts, exceeding 27,000 examinations in total...
February 12, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29448117/refractory-focal-epilepsy-in-a-paediatric-patient-with-primary-familial-brain-calcification
#11
Juliet K Knowles, Jonathan D Santoro, Brenda E Porter, Fiona M Baumer
Primary familial brain calcification (PFBC), otherwise known as Fahr's disease, is a rare autosomal dominant condition with manifestations of movement disorders, neuropsychiatric symptoms, and epilepsy in a minority of PFBC patients. The clinical presentation of epilepsy in PFBC has not been described in detail. We present a paediatric patient with PFBC and refractory focal epilepsy based on seizure semiology and ictal EEG, but with generalized interictal EEG abnormalities. The patient was found to have a SLC20A2 mutation known to be pathogenic in PFBC, as well as a variant of unknown significance in SCN2A...
February 6, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29440496/crispr-cas9-cleavages-in-budding-yeast-reveal-templated-insertions-and-strand-specific-insertion-deletion-profiles
#12
Brenda R Lemos, Adam C Kaplan, Ji Eun Bae, Alexander E Ferrazzoli, James Kuo, Ranjith P Anand, David P Waterman, James E Haber
Harnessing CRISPR-Cas9 technology provides an unprecedented ability to modify genomic loci via DNA double-strand break (DSB) induction and repair. We analyzed nonhomologous end-joining (NHEJ) repair induced by Cas9 in budding yeast and found that the orientation of binding of Cas9 and its guide RNA (gRNA) profoundly influences the pattern of insertion/deletions (indels) at the site of cleavage. A common indel created by Cas9 is a 1-bp (+1) insertion that appears to result from Cas9 creating a 1-nt 5' overhang that is filled in by a DNA polymerase and ligated...
February 13, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29439194/quality-of-life-is-poorer-for-patients-with-stroke-who-require-an-interpreter-an-observational-australian-registry-study
#13
Monique F Kilkenny, Natasha A Lannin, Craig S Anderson, Helen M Dewey, Joosup Kim, Karen Barclay-Moss, Chris Levi, Steven Faux, Kelvin Hill, Brenda Grabsch, Sandy Middleton, Amanda G Thrift, Rohan Grimley, Geoffrey Donnan, Dominique A Cadilhac
BACKGROUND AND PURPOSE: In multicultural Australia, some patients with stroke cannot fully understand, or speak, English. Language barriers may reduce quality of care and consequent outcomes after stroke, yet little has been reported empirically. METHODS: An observational study of patients with stroke or transient ischemic attack (2010-2015) captured from 45 hospitals participating in the Australian Stroke Clinical Registry. The use of interpreters in hospitals, which is routinely documented, was used as a proxy for severe language barriers...
February 9, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29439147/antisense-inhibition-of-protein-tyrosine-phosphatase-1b-with-ionis-ptp-1b-rx-improves-insulin-sensitivity-and-reduces-weight-in-overweight-patients-with-type-2-diabetes
#14
Andres Digenio, Nguyen C Pham, Lynnetta M Watts, Erin S Morgan, Shiangtung W Jung, Brenda F Baker, Richard S Geary, Sanjay Bhanot
OBJECTIVE: To evaluate safety and efficacy of IONIS-PTP-1B Rx , a second-generation 2'- O -methoxyethyl antisense inhibitor of protein tyrosine phosphatase 1B, as add-on therapy in overweight patients with type 2 diabetes inadequately controlled with metformin with or without sulfonylurea therapy. RESEARCH DESIGN AND METHODS: In this phase II, double-blind, randomized, placebo-controlled, multicenter trial, overweight and obese patients (BMI ≥27 kg/m 2 ) with type 2 diabetes (HbA 1c ≥7...
February 9, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29437918/prevalence-of-infection-competent-serogroup-6-legionella-pneumophila-within-premise-plumbing-in-southeast-michigan
#15
Brenda G Byrne, Sarah McColm, Shawn P McElmurry, Paul E Kilgore, Joanne Sobeck, Rick Sadler, Nancy G Love, Michele S Swanson
Coinciding with major changes to its municipal water system, Flint, MI, endured Legionnaires' disease outbreaks in 2014 and 2015. By sampling premise plumbing in Flint in the fall of 2016, we found that 12% of homes harbored legionellae, a frequency similar to that in residences in neighboring areas. To evaluate the genetic diversity of Legionella pneumophila in Southeast Michigan, we determined the sequence type (ST) and serogroup (SG) of the 18 residential isolates from Flint and Detroit, MI, and the 33 clinical isolates submitted by hospitals in three area counties in 2013 to 2016...
February 6, 2018: MBio
https://www.readbyqxmd.com/read/29437671/pharmacological-tlr4-antagonism-using-topical-resatorvid-blocks-solar-uv-induced-skin-tumorigenesis-in-skh-1-mice
#16
Karen Blohm-Mangone, Nichole B Burkett, Shekha Tahsin, Paul B Myrdal, Alhassan Aodah, Brenda Ho, Jaroslav Janda, Michelle McComas, Kathylynn Saboda, Denise J Roe, Zigang Dong, Ann M Bode, Emanuel F Petricoin, Valerie S Calvert, Clara Curiel-Lewandrowski, David S Alberts, Georg T Wondrak, Sally E Dickinson
An urgent need exists for the development of more efficacious molecular strategies targeting non-melanoma skin cancer (NMSC), the most common malignancy worldwide. Inflammatory signaling downstream of Toll-like receptor 4 (TLR4) has been implicated in several forms of tumorigenesis, yet its role in solar UV-induced skin carcinogenesis remains undefined. We have previously shown in keratinocyte cell culture and SKH-1 mouse epidermis that topical application of the specific TLR4 antagonist resatorvid (TAK-242) blocks acute UV-induced AP-1 and NF-κB signaling, associated with downregulation of inflammatory mediators and MAP Kinase phosphorylation...
February 1, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29437466/gene-promoter-hypermethylation-detected-in-sputum-predicts-fev1-decline-and-all-cause-mortality-in-smokers
#17
Shuguang Leng, Brenda Diergaarde, Maria A Picchi, David O Wilson, Frank D Gilliland, Jian-Min Yuan, Jill M Siegfried, Steven A Belinsky
RATIONALE: Gene promoter hypermethylation detected in sputum assesses the extent of field cancerization and predicts lung cancer (LC) risk in ever smokers. A rapid decline of forced expiratory volume in 1 second (FEV1) is a major driver for development of airway obstruction. OBJECTIVES: To assess the effects of methylation of 12 genes on FEV1 decline and of FEV1 decline on subsequent LC incidence using two independent, longitudinal cohorts (i.e., Lovelace Smokers cohort [LSC] and Pittsburgh Lung Screening Study [PLuSS])...
February 13, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29437202/lymphedema-in-ovarian-cancer-survivors-assessing-diagnostic-methods-and-the-effects-of-physical-activity
#18
Neel S Iyer, Brenda Cartmel, Louis Friedman, Fangyong Li, Yang Zhou, Elizabeth Ercolano, Maura Harrigan, Linda Gottlieb, Ruth McCorkle, Peter E Schwartz, Melinda L Irwin
BACKGROUND: Lymphedema is a poorly understood side effect of gynecologic cancer treatment. This study was designed to determine the prevalence of lower limb lymphedema (LLL) in a sample of ovarian cancer survivors via 3 different diagnostic methods and to assess the effect of a randomized exercise intervention. METHODS: Physically inactive ovarian cancer survivors (n = 95) were enrolled in a 6-month randomized trial of exercise (primarily brisk walking) versus attention control...
February 13, 2018: Cancer
https://www.readbyqxmd.com/read/29437077/delirium-assessment-tools-for-use-in-critically-ill-adults-a-psychometric-analysis-and-systematic-review
#19
Céline Gélinas, Mélanie Bérubé, Annie Chevrier, Brenda T Pun, E Wesley Ely, Yoanna Skrobik, Juliana Barr
BACKGROUND: Delirium is highly prevalent in critically ill patients. Its detection with valid tools is crucial. OBJECTIVE: To analyze the development and psychometric properties of delirium assessment tools for critically ill adults. METHODS: Databases were searched to identify relevant studies. Inclusion criteria were English language, publication before January 2015, 30 or more patients, and patient population of critically ill adults (>18 years old)...
February 2018: Critical Care Nurse
https://www.readbyqxmd.com/read/29432385/economic-evaluation-of-selective-neonatal-bcg-vaccination-of-high-risk-infants-in-ireland
#20
Conor Teljeur, Patrick S Moran, Patricia Harrington, Karina Butler, Brenda Corcoran, Joan O'Donnell, Cara Usher, Darina O'Flanagan, Kevin Connolly, Máirín Ryan
BACKGROUND: In Western Europe, currently only Ireland and Portugal continue to provide universal neonatal BCG vaccination programmes, despite not being considered as high TB incidence countries. Other European countries only vaccinate infants considered at high risk of contracting TB. We evaluated the cost-effectiveness of selective BCG vaccination compared to strategies of universal and no vaccination. METHODS: An economic model was used to simulate a cohort from birth to life expectancy, taking the perspective of the publicly-funded healthcare system...
February 9, 2018: Pediatric Infectious Disease Journal
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