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Marvin Gonzalez-Quiroz, Evangelia-Theano Smpokou, Richard J Silverwood, Armando Camacho, Dorien Faber, Brenda La Rosa Garcia, Amin Oomatia, Michael Hill, Jason Glaser, Jennifer Le Blond, Catharina Wesseling, Aurora Aragon, Liam Smeeth, Neil Pearce, Dorothea Nitsch, Ben Caplin
Background Epidemic levels of CKD of undetermined cause, termed Mesoamerican nephropathy in Central America, have been found in low- and middle-income countries. We investigated the natural history of, and factors associated with, loss of kidney function in a population at high risk for this disease. Methods We conducted a 2-year prospective, longitudinal study with follow-up every 6 months in nine rural communities in northwestern Nicaragua and included all men ( n =263) and a random sample of women ( n =87) ages 18-30 years old without self-reported CKD, diabetes, or hypertension...
June 15, 2018: Journal of the American Society of Nephrology: JASN
Anne G Sadler, Ann M Cheney, Michelle A Mengeling, Brenda M Booth, James C Torner, Lance Brendan Young
Despite growing recognition of the high rates of sexual violence experienced by men serving in the U.S. military, male victimization, specifically sexual assault in military (SAIM), is an understudied topic. We qualitatively describe servicemen's awareness and perceptions of male SAIM, and their understanding of common barriers to servicemen reporting sexual assault. Participants included Midwestern Active Component and Reserve and National Guard servicemen, actively serving or Veteran, who had returned from Iraq or Afghanistan deployments during Operation Enduring/Iraqi Freedom eras...
June 1, 2018: Journal of Interpersonal Violence
Jonathan Huang, Brenda Eskenazi, Riana Bornman, Stephen Rauch, Jonathan Chevrier
BACKGROUND: Indoor residual spraying (IRS) of insecticides, conducted in low- and middle-income countries to control malaria, may result in high exposure to dichlorodiphenyltrichloroethane (DDT), its breakdown product dichlorodiphenyldichloroethylene (DDE), or pyrethroids. Animal studies suggest in utero exposure to these chemicals may increase childhood infection frequency. OBJECTIVES: We investigated associations between maternal DDT/E and pyrethroid metabolite concentration and child infection associations in an IRS setting in which susceptibility factors are common and infections are leading causes of child morbidity and mortality...
June 2018: Environmental Health Perspectives
M Catherine Pietanza, Saiama N Waqar, Lee M Krug, Afshin Dowlati, Christine L Hann, Alberto Chiappori, Taofeek K Owonikoko, Kaitlin M Woo, Robert J Cardnell, Junya Fujimoto, Lihong Long, Lixia Diao, Jing Wang, Yevgeniva Bensman, Brenda Hurtado, Patricia de Groot, Erik P Sulman, Ignacio I Wistuba, Alice Chen, Martin Fleisher, John V Heymach, Mark G Kris, Charles M Rudin, Lauren Averett Byers
Purpose Both temozolomide (TMZ) and poly (ADP-ribose) polymerase (PARP) inhibitors are active in small-cell lung cancer (SCLC). This phase II, randomized, double-blind study evaluated whether addition of the PARP inhibitor veliparib to TMZ improves 4-month progression-free survival (PFS). Patients and Methods A total of 104 patients with recurrent SCLC were randomly assigned 1:1 to oral veliparib or placebo 40 mg twice daily, days 1 to 7, and oral TMZ 150 to 200 mg/m2 /day, days 1 to 5, of a 28-day cycle until disease progression, unacceptable toxicity, or withdrawal of consent...
June 15, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Margaret OʼDonnell, Kathleen Shurpin, Brenda Janotha
BACKGROUND AND PURPOSE: Despite demonstrated efficacy, the utilization of herpes zoster vaccine (HZV), recommended by the Centers for Disease Control (CDC) for all immunocompetent adults aged above 60 years, is low (31%). The aim of this study was to identify nurse practitioner (NP) barriers to HZV administration and then to use these results to develop and evaluate the outcomes of an educational program. METHODS: This study used a two-phase design. In Phase I, barriers that obstruct the provision of HZV were identified and NPs were surveyed to determine current HZV practice...
June 4, 2018: Journal of the American Association of Nurse Practitioners
Cláudio Régis Sampaio Silveira, Clarissa Gadelha Maia Vieira, Brenda Machado Pereira, Edson Lopes, Gunter Gerson, Daniel Gurgel Fernandes Távora, Avneesh Chhabra
Magnetic resonance neurography is a technique for identifying anatomy and pathologic lesions of nerves, and has emerged as a helpful technique for localizing lesions and elucidating the underlying etiology. Ganglioneuromas are highly differentiated benign tumors. This lesion is rare and exhibits undetermined symptoms, the features of using the magnetic resonance neurography are a great ally to determine its diagnosis. The authors illustrate a case of retroperitoneal ganglioneuroma emphasizing its image characteristics using magnetic resonance neurography with the diagnosis confirmed by histopathological examination...
April 2018: Radiology Case Reports
Brenda F Kurland, Steffi Oesterreich
No abstract text is available yet for this article.
June 14, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Jing Hou, Jolanda van Leeuwen, Brenda J Andrews, Charles Boone
The phenotypic consequences of a given mutation can vary across individuals. This so-called background effect is widely observed, from mutant fitness of loss-of-function variants in model organisms to variable disease penetrance and expressivity in humans; however, the underlying genetic basis often remains unclear. Taking insights gained from recent large-scale surveys of genetic interaction and suppression analyses in yeast, we propose that the genetic network context for a given mutation may shape its propensity of exhibiting background-dependent phenotypes...
June 11, 2018: Trends in Genetics: TIG
Saul Shiffman, Brenda F Kurland, Sarah M Scholl, Jason M Mao
Importance: The US Food and Drug Administration is considering limiting cigarettes to very low nicotine levels. Cigarette consumption of nondaily intermittent smokers (ITS), who compose one-third of US adult smokers, could feasibly increase or could be unaffected if their smoking is not motivated by nicotine seeking. Objective: To compare cigarette consumption in ITS receiving very low-nicotine-content cigarettes (VLNCCs) or identical normal-nicotine-content cigarettes (NNCCs)...
June 14, 2018: JAMA Psychiatry
Hsieh Fushing, Shan-Yu Liu, Yin-Chen Hsieh, Brenda McCowan
Data generated from a system of interest typically consists of measurements on many covariate features and possibly multiple response features across all subjects in a designated ensemble. Such data is naturally represented by one response-matrix against one covariate-matrix. A matrix lattice is an advantageous platform for simultaneously accommodating heterogeneous data types: continuous, discrete and categorical, and exploring hidden dependency among/between features and subjects. After each feature being individually renormalized with respect to its own histogram, the categorical version of mutual conditional entropy is evaluated for all pairs of response and covariate features according to the combinatorial information theory...
2018: PloS One
Marlos Barbosa-Ribeiro, Rodrigo Arruda-Vasconcelos, Fabio L Fabretti, Emmanuel J N L Silva, Gustavo De-Deus, Brenda P F A Gomes
This study evaluated the amount of apically extruded debris after chemo-mechanical preparation (CMP) using positive and negative pressure irrigation systems [Conventional irrigation (CI) and EndoVac (EV)] in association with different irrigants [6% Sodium Hypochlorite (NaOCl), 2% Chlorhexidine gel + saline solution (CHXg + SS), 2% Chlorhexidine solution (CHXs) or Saline solution (SS)]. Eighty mandibular premolars with single root canals were selected and randomly assigned into 8 groups (n = 10) according to the irrigation system and the irrigant used during CMP: G1 (EV + NaOCl), G2 (EV + CHXg + SS), G3 (EV + CHXs), G4 (EV + SS), G5 (CI + NaOCl), G6 (CI + CHXg + SS), G7 (CI + CHXs) and G8 (CI + SS)...
March 2018: Brazilian Dental Journal
Merijn Eikelenboom, Aartjan T F Beekman, Brenda W J H Penninx, Johannes H Smit
BACKGROUND: Major depressive disorder (MDD), represent a major source of risk for suicidality. However, knowledge about risk factors for future suicide attempts (SAs) within MDD is limited. The present longitudinal study examined a wide range of putative non-clinical risk factors (demographic, social, lifestyle, personality) and clinical risk factors (depressive and suicidal indicators) for future SAs among persons with MDD. Furthermore, we examined the relationship between a number of significant predictors and the incidence of a future SA...
June 13, 2018: Psychological Medicine
Priya Govindaraju, Leslie Todd, Snehal Shetye, James Monslow, Ellen Puré
Cutaneous wound healing consists of three main phases: inflammation, re-epithelialization, and tissue remodeling. During normal wound healing, these processes are tightly regulated to allow restoration of skin function and biomechanics. In many instances, healing leads to an excess accumulation of fibrillar collagen (the principal protein found in the extracellular matrix - ECM), and the formation of scar tissue, which has compromised biomechanics, tested using ramp to failure tests, compared to normal skin (Corr and Hart, 2013 [1])...
June 9, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
Taryn Huizenga, Jessica A Kado, Brenda Pellicane, Judy Borovicka, Darius R Mehregan, David A Mehregan
No abstract text is available yet for this article.
May 2018: Cutis; Cutaneous Medicine for the Practitioner
Brenda Happell, Brett Scholz, Sarah Gordon, Julia Bocking, Pete Ellis, Cath Roper, Jackie Liggins, Chris Platania-Phung
INTRODUCTION: Australia and New Zealand mental health policy requires consumer participation in all aspects of mental health services. Systemic participation informs and improves the quality of mental health services. Collaboration with consumer researchers should be similarly required. Enhanced understandings of collaborations are needed. AIM: To enhance understanding of the perspectives and experiences of nonconsumer researchers in working collaboratively with consumers as researchers...
June 12, 2018: Journal of Psychiatric and Mental Health Nursing
Lonneke A van Tuijl, Klaske A Glashouwer, Hermien J Elgersma, Claudi L H Bockting, Brenda W J H Penninx, Peter J de Jong
No abstract text is available yet for this article.
June 5, 2018: Behaviour Research and Therapy
Johnathan M Goldman, Haresh T More, Olga Yee, Elizabeth Borgeson, Brenda Remy, Jasmine Rowe, Vikram Sadineni
Development of optimal drug product lyophilization cycles is typically accomplished via multiple engineering runs to determine appropriate process parameters. These runs require significant time and product investments, which are especially costly during early phase development when the drug product formulation and lyophilization process are often defined simultaneously. Even small changes in the formulation may require a new set of engineering runs to define lyophilization process parameters. In order to overcome these development difficulties, an eight factor definitive screening design (DSD), including both formulation and process parameters, was executed on a fully human monoclonal antibody (mAb) drug product...
June 8, 2018: Journal of Pharmaceutical Sciences
Roxanne Schaakxs, Hannie C Comijs, Femke Lamers, Rob M Kok, Aartjan T F Beekman, Brenda W J H Penninx
BACKGROUND: Although there is some evidence that older people might have a poorer course of major depressive disorder (MDD) than younger or middle-aged people, and that age-related course differences might affect the optimisation of MDD treatment, large-scale studies with a broad age range, including consistent course assessments, are needed to properly address this issue. Therefore, we aimed to longitudinally examine whether older age was associated with a poorer naturalistic course trajectory of MDD than that of younger ages and to establish which prognostic-clinical, social, and health-factors could explain this potentially poorer course...
June 7, 2018: Lancet Psychiatry
Jacques J D M van Lankveld, Joke Fleer, Maya J Schroevers, Robbert Sanderman, Brenda L den Oudsten, Joost Dekker
No abstract text is available yet for this article.
June 10, 2018: Psycho-oncology
Erik J Timmermans, Jeroen Lakerveld, Joline W J Beulens, Dorret I Boomsma, Sophia E Kramer, Mirjam Oosterman, Gonneke Willemsen, Mariska Stam, Giel Nijpels, Carlo Schuengel, Jan H Smit, Bert Brunekreef, Jasper E C Dekkers, Dorly J H Deeg, Brenda W J H Penninx, Martijn Huisman
PURPOSE: In the Netherlands, a great variety of objectively measured geo-data is available, but these data are scattered and measured at varying spatial and temporal scales. The centralisation of these geo-data and the linkage of these data to individual-level data from longitudinal cohort studies enable large-scale epidemiological research on the impact of the environment on public health in the Netherlands. In the Geoscience and Health Cohort Consortium (GECCO), six large-scale and ongoing cohort studies have been enriched with a variety of existing geo-data...
June 9, 2018: BMJ Open
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