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https://www.readbyqxmd.com/read/28068606/trehalose-does-not-improve-neuronal-survival-on-exposure-to-alpha-synuclein-pre-formed-fibrils
#1
Matthew Redmann, Willayat Y Wani, Laura Volpicelli-Daley, Victor Darley-Usmar, Jianhua Zhang
Parkinson's disease is a debilitating neurodegenerative disorder that is pathologically characterized by intracellular inclusions comprised primarily of alpha-synuclein (αSyn) that can also be transmitted from neuron to neuron. Several lines of evidence suggest that these inclusions cause neurodegeneration. Thus exploring strategies to improve neuronal survival in neurons with αSyn aggregates is critical. Previously, exposure to αSyn pre-formed fibrils (PFFs) has been shown to induce aggregation of endogenous αSyn resulting in cell death that is exacerbated by either starvation or inhibition of mTOR by rapamycin, both of which are able to induce autophagy, an intracellular protein degradation pathway...
January 3, 2017: Redox Biology
https://www.readbyqxmd.com/read/28035775/reducing-liberal-red-blood-cell-transfusions-at-an-academic-medical-center
#2
Harry S Saag, Claudette M Lajam, Simon Jones, Nikita Lakomkin, Joseph A Bosco, Rebecca Wallack, Spiros G Frangos, Prashant Sinha, Nicole Adler, Patti Ursomanno, Leora I Horwitz, Frank M Volpicelli
BACKGROUND: Educational and computerized interventions have been shown to reduce red blood cell (RBC) transfusion rates, yet controversy remains surrounding the optimal strategy needed to achieve sustained reductions in liberal transfusions. STUDY DESIGN AND METHODS: The purpose of this study was to assess the impact of clinician decision support (CDS) along with targeted education on liberal RBC utilization to four high-utilizing service lines compared with no education to control service lines across an academic medical center...
December 30, 2016: Transfusion
https://www.readbyqxmd.com/read/28008681/prediction-rule-for-diagnosis-of-pulmonary-embolism-enhanced-by-lung-and-venous-ultrasound-making-confusion-or-increasing-efficiency
#3
Giovanni Volpicelli, Simone Vanni, Cecilia Becattini, Giuseppe Francesco Sferrazza Papa, Chiara Gigli, Stefano Grifoni, Peiman Nazerian
We thank the Authors for their interest in our study [1] and the questions raised. Our response begins from their conclusion: "…we fear that uWells' may create more noise than signal in the already murky PE milieu". We find curious that two strongly evidence based applications of point-of-care ultrasound (POCUS) added to the clinical evaluation might create confusion rather than resolving challenging questions. This article is protected by copyright. All rights reserved.
December 22, 2016: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/27981283/lung-artefacts-and-their-use
#4
REVIEW
Christoph F Dietrich, Gebhard Mathis, Michael Blaivas, Giovanni Volpicelli, Armin Seibel, Nathan S Atkinson, Xin Wu Cui, Fan Mei, Dagmar Schreiber-Dietrich, Dong Yi
The science of lung ultrasound has grown tremendously over the last two decades and lung ultrasound has not only entered the mainstream of point of care ultrasound but has become a dominant topic. Understanding lung ultrasound signs and artifacts is critical to being able to correlate findings with actual pathology and normal anatomy and physiology. Investigators have described multiple lung ultrasound artifacts and findings and it is important to understand both the physics and anatomic basis behind them...
December 5, 2016: Medical Ultrasonography
https://www.readbyqxmd.com/read/27956085/effects-of-%C3%AE-synuclein-on-axonal-transport
#5
Laura A Volpicelli-Daley
Lewy bodies and Lewy neurites composed primarily of α-synuclein characterize synucleinopathies including Parkinson's disease (PD) and Dementia with Lewy Bodies (DLB). Despite decades of research on the impact of α-synuclein, little is known how abnormal inclusion made of this protein compromise neuronal function. Emerging evidence suggests that defects in axonal transport caused by aggregated α-synuclein contribute to neuronal dysfunction. These defects appear to occur well before the onset of neuronal death...
December 9, 2016: Neurobiology of Disease
https://www.readbyqxmd.com/read/27859891/diagnostic-performance-of-wells-score-combined-with-point-of-care-lung-and-venous-ultrasound-in-suspected-pulmonary-embolism
#6
Peiman Nazerian, Giovanni Volpicelli, Chiara Gigli, Cecilia Becattini, Giuseppe Francesco Sferrazza Papa, Stefano Grifoni, Simone Vanni
OBJECTIVE: Lung and venous ultrasound are bedside diagnostic tools increasingly used in the early diagnostic approach of suspected pulmonary embolism (PE). However, the possibility of improving the conventional prediction rule for PE by integrating ultrasound has never been investigated. METHODS: We performed lung and venous ultrasound in consecutive patients suspected of PE in four emergency departments. Conventional Wells score (Ws) was adjudicated by the attending physician, and ultrasound was performed by one of 20 investigators...
November 12, 2016: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/27830508/diagnostic-accuracy-of-lung-ultrasonography-combined-with-procalcitonin-for-the-diagnosis-of-pneumonia-a-pilot-study
#7
Peiman Nazerian, Gabriele Cerini, Simone Vanni, Chiara Gigli, Maurizio Zanobetti, Maurizio Bartolucci, Stefano Grifoni, Giovanni Volpicelli
BACKGROUND: The diagnostic value of lung ultrasonography (LUS) and procalcitonin (PCT) in the diagnosis of lung infections is known. No studies evaluated the combination of LUS and PCT for the diagnosis of pneumonia in the emergency department (ED). We evaluated the diagnostic accuracy of the combination of LUS and PCT in the diagnosis of pneumonia. METHODS: Patients with respiratory symptoms of unexplained origin who underwent a chest CT in ED were included in the study if PCT assay was available...
December 2016: Critical Ultrasound Journal
https://www.readbyqxmd.com/read/27797414/tpo-ras-in-pitp-description-of-a-case-series-and-analysis-of-predictive-factors-for-response
#8
M G Mazzucconi, C Santoro, E Baldacci, F De Angelis, M Chisini, G Ferrara, P Volpicelli, R Foà
OBJECTIVE: To report our experience concerning sustained response (SR) after TPO-RAs discontinuation in adult pITP patients and to identify possible predictive factors for outcome. METHODS: Thirty-nine pITP patients who received a TPO-RA were evaluated. Response (R) was defined as a platelet count ≥30x10(9) /L and at least a two-fold increase of the baseline count and complete response (CR) as a platelet count ≥100x10(9) /L, in absence of bleeding. Durable response (DR) was defined as a R/CR persisting ≥4 weeks with a stable dose of TPO-RA, and SR as the first assessed platelet count ≥30x10(9) /L, available at more than 4 weeks after discontinuation of TPO-RA, in absence of other concomitant or rescue therapies...
October 31, 2016: European Journal of Haematology
https://www.readbyqxmd.com/read/27783380/common-pitfalls-in-point-of-care-ultrasound-a-practical-guide-for-emergency-and-critical-care-physicians
#9
REVIEW
Pablo Blanco, Giovanni Volpicelli
BACKGROUND: Point-of-care ultrasonography (POCUS) is a widely used tool in emergency and critical care settings, useful in the decision-making process as well as in interventional guidance. While having an impressive diagnostic accuracy in the hands of highly skilled operators, inexperienced practitioners must be aware of some common misinterpretations that may lead to wrong decisions at the bedside. OBJECTIVES: This article provides a revision list of common POCUS misdiagnoses usually found in practice and offers useful tips to recognize and avoid them...
December 2016: Critical Ultrasound Journal
https://www.readbyqxmd.com/read/27718083/intestinal-lipomatosis-and-chemotherapy-a-growing-concern
#10
S Hu, Amirkaveh Mojtahed, A Covington, W Thompson, N Volpicelli, Denis McCarthy
No abstract text is available yet for this article.
November 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27449783/do-social-factors-predict-appropriate-treatment-of-child-diarrheal-disease-in-peru
#11
Kathryn Volpicelli, Alison M Buttenheim
Objectives Diarrheal disease is a significant cause of morbidity among children in Peru. Oral rehydration therapy (ORT) is a cost-effective evidence-based approach to treat diarrhea in young children, yet many Peruvian children in poorer households do not receive this life-saving treatment. This study investigates the social determinants of care-seeking behavior and utilization of appropriate home treatment for diarrheal episodes. Methods We used the nationally-representative 2008 Peru Demographic and Health Survey to: (1) describe the burden of non-bloody diarrheal disease among children <5 years old; and (2) identify socioeconomic correlates of care-seeking behavior and utilization/appropriateness of treatment among mothers of children with recent non-bloody diarrheal episodes (N = 1365)...
July 23, 2016: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/27413152/g2019s-lrrk2-expression-augments-%C3%AE-synuclein-sequestration-into-inclusions-in-neurons
#12
Laura A Volpicelli-Daley, Hisham Abdelmotilib, Zhiyong Liu, Lindsay Stoyka, João Paulo Lima Daher, Austen J Milnerwood, Vivek K Unni, Warren D Hirst, Zhenyu Yue, Hien T Zhao, Kyle Fraser, Richard E Kennedy, Andrew B West
UNLABELLED: Pathologic inclusions define α-synucleinopathies that include Parkinson's disease (PD). The most common genetic cause of PD is the G2019S LRRK2 mutation that upregulates LRRK2 kinase activity. However, the interaction between α-synuclein, LRRK2, and the formation of α-synuclein inclusions remains unclear. Here, we show that G2019S-LRRK2 expression, in both cultured neurons and dopaminergic neurons in the rat substantia nigra pars compact, increases the recruitment of endogenous α-synuclein into inclusions in response to α-synuclein fibril exposure...
July 13, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27312683/lung-ultrasound-utility-in-the-management-of-the-neurologically-deceased-organ-donor
#13
Daniel J Lebovitz, Matthew Tabbut, Samir Q Latifi, Lynn Dezelon, Robert Jones
CONTEXT: Lung transplantation is limited by donor lung availability with ∼20% of deceased donor lungs transplanted. Diagnostic testing identifying pulmonary derangements guide donor management strategies to maximize lung transplantation. Lung ultrasound (LUS) identifies pathology in critically ill patients equivalent or superior to chest radiograph (CXR) or computed tomography (CT) scans. No published studies have reported on LUS in neurologically deceased donors (DNDDs). OBJECTIVE: We evaluated LUS in identifying abnormal lung pathology in DNDDs and related these findings to the standard approach...
September 2016: Progress in Transplantation
https://www.readbyqxmd.com/read/27293860/lung-b-line-artefacts-and-their-use
#14
REVIEW
Christoph F Dietrich, Gebhard Mathis, Michael Blaivas, Giovanni Volpicelli, Armin Seibel, Daniel Wastl, Nathan S S Atkinson, Xin-Wu Cui, Mei Fan, Dong Yi
BACKGROUND: The analysis of lung artefacts has gained increasing importance as markers of lung pathology. B-line artefact (BLA), caused by a reverberation phenomenon, is the most important lung artefact. In this review, we discuss the current role of BLA in pneumology and explore open questions of the published consensus. METHODS: We summarized current literature about BLA. Also, we presented observations on healthy subjects and patients with interstitial syndrome (pulmonary fibrosis and edema), to investigate technical factors influencing BLA visualization...
June 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27158433/life-threatening-autoimmune-hemolytic-anemia-and-idhiopatic-thrombocytopenic-purpura-successful-selective-splenic-artery-embolization
#15
Matteo Molica, Fulvio Massaro, Giorgia Annechini, Erminia Baldacci, Gianna Maria D'Elia, Riccardo Rosati, Silvia Maria Trisolini, Paola Volpicelli, Robin Foà, Saveria Capria
Selective splenic artery embolization (SSAE) is a nonsurgical intervention characterized by the transcatheter occlusion of the splenic artery and/or its branch vessels using metallic coils or other embolic devices. It has been applied for the management of splenic trauma, hypersplenism with portal hypertension, hereditary spherocytosis, thalassemia and splenic hemangioma. We hereby describe a case of a patient affected by idiopathic thrombocytopenic purpura (ITP) and warm auto-immune hemolytic anemia (AIHA) both resistant to immunosuppressive and biological therapies, not eligible for a surgical intervention because of her critical conditions...
2016: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/27086910/retraction-notice-to-gallstone-ileus-without-bilioenteric-fistula-years-after-bypass-surgery-for-crohn-s-disease-case-report-and-clues-to-etiology-of-a-neglected-cause-of-obstruction-ijscr-volume-9-2015-pages-134-138
#16
(no author information available yet)
This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). The report has been retracted at the request of the authors. Following notification by the family of the patient covered by this case report it was discovered and confirmed by an institutional investigation that the report contained serious reporting errors including the confusion of the case with another case that was structurally different. The authors apologise sincerely to the family of the patient for the error and distress caused by the publication...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27018978/how-can-raav-%C3%AE-synuclein-and-the-fibril-%C3%AE-synuclein-models-advance-our-understanding-of-parkinson-s-disease
#17
REVIEW
Laura A Volpicelli-Daley, Deniz Kirik, Lindsay E Stoyka, David G Standaert, Ashley S Harms
Animal models of Parkinson's disease (PD) are important for understanding the mechanisms of the disease and can contribute to developing and validating novel therapeutics. Ideally, these models should replicate the cardinal features of PD, such as progressive neurodegeneration of catecholaminergic neurons and motor defects. Many current PD models emphasize pathological forms of α-synuclein, based on findings that autosomal dominant mutations in α-synuclein and duplications/triplications of the SNCA gene cause PD...
October 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/26951426/ultrasonography-evaluation-during-the-weaning-process-the-heart-the-diaphragm-the-pleura-and-the-lung
#18
REVIEW
P Mayo, G Volpicelli, N Lerolle, A Schreiber, P Doelken, A Vieillard-Baron
PURPOSE: On a regular basis, the intensivist encounters the patient who is difficult to wean from mechanical ventilatory support. The causes for failure to wean from mechanical ventilatory support are often multifactorial and involve a complex interplay between cardiac and pulmonary dysfunction. A potential application of point of care ultrasonography relates to its utility in the process of weaning the patient from mechanical ventilatory support. METHODS: This article reviews some applications of ultrasonography that may be relevant to the process of weaning from mechanical ventilatory support...
July 2016: Intensive Care Medicine
https://www.readbyqxmd.com/read/26911687/microrna-155-regulates-alpha-synuclein-induced-inflammatory-responses-in-models-of-parkinson-disease
#19
Aaron D Thome, Ashley S Harms, Laura A Volpicelli-Daley, David G Standaert
Increasing evidence points to inflammation as a chief mediator of Parkinson's disease (PD), a progressive neurodegenerative disorder characterized by loss of dopamine neurons in the substantia nigra pars compacta (SNpc) and widespread aggregates of the protein α-synuclein (α-syn). Recently, microRNAs, small, noncoding RNAs involved in regulating gene expression at the posttranscriptional level, have been recognized as important regulators of the inflammatory environment. Using an array approach, we found significant upregulation of microRNA-155 (miR-155) in an in vivo model of PD produced by adeno-associated-virus-mediated expression of α-syn...
February 24, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/26888754/phantom-model-and-scoring-system-to-assess-ability-in-ultrasound-guided-chest-drain-positioning
#20
Luigi Vetrugno, Giovanni Volpicelli, Federico Barbariol, Ilaria Toretti, Livia Pompei, Francesco Forfori, Giorgio Della Rocca
BACKGROUND: Chest tube positioning is an invasive procedure associated with potentially serious injuries. In the last few years, we have been running a project directed at developing a practical simulator of a surgical procedure taught on our medical training program. The phantom model reconstructs the pleural anatomy, visible by lung ultrasound, used for the assessed performance of the Seldinger technique. The aim of the present study was to investigate the validity of this simulation technology for assessing residents in anesthesia and intensive care medicine; specifically, their skill in positioning a US-guided chest tube drain was tested using the simulator device...
December 2016: Critical Ultrasound Journal
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