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https://www.readbyqxmd.com/read/28093269/invasive-disease-versus-urinary-antigen-confirmed-pneumococcal-community-acquired-pneumonia
#1
Adrian Ceccato, Antoni Torres, Catia Cilloniz, Rosanel Amaro, Albert Gabarrus, Eva Polverino, Elena Prina, Carolina Garcia-Vidal, Eva Muñoz-Conejero, Cristina Mendez, Isabel Cifuentes, Jorge Puig de la Bella Casa, Rosario Menendez, Michael S Niederman
OBJECTIVES: The burden of pneumococcal disease is measured only through patients with invasive pneumococcal disease. The urinary antigen test (UAT) for pneumococcus has exhibited a high sensitivity and specificity. We aimed to compare the pneumococcal pneumonias diagnosed as invasive disease with pneumococcal pneumonias defined by UAT. METHODS: Prospective observational study on consecutive non-immunosuppressed patients with community-acquired pneumonia from January 2000 to December 2014...
January 13, 2017: Chest
https://www.readbyqxmd.com/read/28093266/comparative-analysis-of-nk-cell-receptor-repertoire-in-adults-and-very-elderly-subjects-with-cytomegalovirus-infection
#2
Guillermo Juárez-Vega, Velia Rangel-Ramírez, Adriana Monsiváis-Urenda, Perla Niño-Moreno, Christian Garcia-Sepúlveda, Daniel E Noyola, Roberto González-Amaro
Human cytomegalovirus (HCMV) infection in children and young adults has been associated with changes in the innate immune system. We herein analyzed the possible effect of very long term HCMV infection on the expression of several NK cell receptors. Ninety HCMV-seropositive individuals were included and classified as young adults (n=30), elderly (n=30) and very elderly subjects (n=30). A peripheral blood sample was obtained and the expression of NK cell receptors (NKG2A, NKG2C, ILT2, CD161, KIR2DL1, KIR3DL1, and KIR3DL2) by NK and other lymphocyte subsets was assessed by flow cytometry...
January 13, 2017: Human Immunology
https://www.readbyqxmd.com/read/28068772/a-reflection-on-klaus-schulten
#3
Rommie E Amaro
No abstract text is available yet for this article.
January 10, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28062859/outcomes-after-direct-thrombectomy-or-combined-intravenous-and-endovascular-treatment-are-not-different
#4
Sònia Abilleira, Aida Ribera, Pedro Cardona, Marta Rubiera, Elena López-Cancio, Sergi Amaro, Ana Rodríguez-Campello, Pol Camps-Renom, David Cánovas, Maria Angels de Miquel, Alejandro Tomasello, Sebastian Remollo, Antonio López-Rueda, Elio Vivas, Joan Perendreu, Miquel Gallofré
BACKGROUND AND PURPOSE: Whether intravenous thrombolysis adds a further benefit when given before endovascular thrombectomy (EVT) is unknown. Furthermore, intravenous thrombolysis delays time to groin puncture, mainly among drip and ship patients. METHODS: Using region-wide registry data, we selected cases that received direct EVT or combined intravenous thrombolysis+EVT for anterior circulation strokes between January 2011 and October 2015. Treatment effect was estimated by stratification on a propensity score...
January 6, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28061740/prevalence-and-determinants-of-bullying-among-health-care-workers-in-portugal
#5
Pedro Norton, Viviana Costa, Joel Teixeira, Ana Azevedo, António Roma-Torres, Joana Amaro, Liliana Cunha
Bullying is defined as systematic exposure to humiliation as well as hostile and violent behaviors against one or more individuals. These behaviors are a serious, growing problem, which affects a significant proportion of health care professionals. To support the hospital's risk management policy, a cross-sectional study was undertaken to determine the prevalence of bullying in this institution and identify the determinants of bullying. Bullying was measured using the Negative Acts Questionnaire-Revised, Portuguese version (NAQ-R), a self-administered tool...
January 1, 2017: Workplace Health & Safety
https://www.readbyqxmd.com/read/28059143/influence-of-coronary-artery-disease-and-subclinical-atherosclerosis-related-polymorphisms-on-the-risk-of-atherosclerosis-in-rheumatoid-arthritis
#6
Raquel López-Mejías, Alfonso Corrales, Esther Vicente, Montserrat Robustillo-Villarino, Carlos González-Juanatey, Javier Llorca, Fernanda Genre, Sara Remuzgo-Martínez, Trinidad Dierssen-Sotos, José A Miranda-Filloy, Marco A Ramírez Huaranga, Trinitario Pina, Ricardo Blanco, Juan J Alegre-Sancho, Enrique Raya, Verónica Mijares, Begoña Ubilla, Iván Ferraz-Amaro, Carmen Gómez-Vaquero, Alejandro Balsa, Francisco J López-Longo, Patricia Carreira, Isidoro González-Álvaro, J Gonzalo Ocejo-Vinyals, Luis Rodríguez-Rodríguez, Benjamín Fernández-Gutiérrez, Santos Castañeda, Javier Martín, Miguel A González-Gay
A genetic component influences the development of atherosclerosis in the general population and also in rheumatoid arthritis (RA). However, genetic polymorphisms associated with atherosclerosis in the general population are not always involved in the development of cardiovascular disease (CVD) in RA. Accordingly, a study in North-American RA patients did not show the association reported in the general population of coronary artery disease with a series of relevant polymorphisms (TCF21, LPA, HHIPL1, RASD1-PEMT, MRPS6, CYP17A1-CNNM2-NT5C2, SMG6-SRR, PHACTR1, WDR12 and COL4A1-COL4A2)...
January 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28055580/diagnosing-borreliosis
#7
Sally J Cutler, Nataliia Rudenko, Maryna Golovchenko, Wibke J Cramaro, Josiane Kirpach, Sara Savic, Iva Christova, Ana Amaro
Borrelia species fall into two groups, the Borrelia burgdorferi sensu lato (Bbsl) complex, the cause of Lyme borreliosis (also known as Lyme disease), and the relapsing fever group. Both groups exhibit inter- and intraspecies diversity and thus have variations in both clinical presentation and diagnostic approaches. A further layer of complexity is derived from the fact that ticks may carry multiple infectious agents and are able to transmit them to the host during blood feeding, with potential overlapping clinical manifestations...
January 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28055576/practical-guidelines-for-studies-on-sandfly-borne-phleboviruses-part-i-important-points-to-consider-ante-field-work
#8
Nazli Ayhan, Amal Baklouti, Jorian Prudhomme, Gernot Walder, Fatima Amaro, Bulent Alten, Sara Moutailler, Koray Ergunay, Remi N Charrel, Hartwig Huemer
The purpose of this review is to provide practical information to help researchers intending to perform "from field to laboratory" studies on phleboviruses transmitted by sandflies. This guideline addresses the different steps to be considered starting from the field collection of sandflies to the laboratory techniques aiming at the detection, isolation, and characterization of sandfly-borne phleboviruses. In this guideline article, we address the impact of various types of data for an optimal organization of the field work intending to collect wildlife sandflies for subsequent virology studies...
January 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28055572/practical-guidelines-for-studies-on-sandfly-borne-phleboviruses-part-ii-important-points-to-consider-for-fieldwork-and-subsequent-virological-screening
#9
Hartwig Huemer, Jorian Prudhomme, Fatima Amaro, Amal Baklouti, Gernot Walder, Bulent Alten, Sara Moutailler, Koray Ergunay, Remi N Charrel, Nazli Ayhan
In this series of review articles entitled "Practical guidelines for studies on sandfly-borne phleboviruses," the important points to be considered at the prefieldwork stage were addressed in part I, including parameters to be taken into account to define the geographic area for sand fly trapping and how to organize field collections. Here in part II, the following points have been addressed: (1) factors influencing the efficacy of trapping and the different types of traps with their respective advantages and drawbacks, (2) how to process the trapped sand flies in the field, and (3) how to process the sand flies in the virology laboratory...
January 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28036253/correction-suppression-of-transcriptional-drift-extends-c-elegans-lifespan-by-postponing-the-onset-of-mortality
#10
Sunitha Rangaraju, Gregory M Solis, Ryan C Thompson, Rafael L Gomez-Amaro, Leo Kurian, Sandra E Encalada, Alexander B Niculescu, Daniel R Salomon, Michael Petrascheck
No abstract text is available yet for this article.
December 30, 2016: ELife
https://www.readbyqxmd.com/read/28018993/sleep-duration-sedentary-behaviors-and-physical-activity-across-weight-status-in-hispanic-toddlers-participants-of-the-wic-program
#11
José Molina, Kiara Amaro, Cynthia M Pérez, Cristina Palacios
OBJECTIVE: To describe physical activity, sedentary behaviors and sleep duration in toddlers' participants of the WIC program in Puerto Rico and assess its association with excessive weight. METHODS: This was a cross-sectional analysis of data gathered in the follow-up visit (12 months later) of a longitudinal study among toddlers 12-36 months old participants of the WIC program. In this follow-up visit, a Sleep, Sedentary Behaviors and Physical Activity Questionnaire was included...
2016: J Child Obes
https://www.readbyqxmd.com/read/28013043/a-field-evaluation-of-an-isothermal-dna-amplification-assay-for-the-detection-of-theileria-annulata-infection-in-cattle
#12
Jacinto Gomes, Marcos Santos, Ana Amaro, Isabel Pereira da Fonseca, Gabriela Santos-Gomes, João Inácio
A loop-mediated isothermal amplification (LAMP) assay was evaluated for the detection of Theileria annulata infection in cattle. The results were compared with a real-time PCR used for the quantification of T. annulata parasitaemia. One hundred bovine blood samples from 16 cattle farms were tested with LAMP and real-time PCR, with T. annulata DNA being detected in 66% and 67% of the samples, respectively. The results showed that the LAMP assay detects a parasitaemia as low as 0.00025%, indicating a high analytical sensitivity of LAMP for clinical diagnosis of bovine theileriosis...
December 22, 2016: Molecular and Cellular Probes
https://www.readbyqxmd.com/read/28008713/engineering-ashbya-gossypii-strains-for-de-novo-lipid-production-using-industrial-by-products
#13
Patricia Lozano-Martínez, Rubén M Buey, Rodrigo Ledesma-Amaro, Alberto Jiménez, José Luis Revuelta
Ashbya gossypii is a filamentous fungus that naturally overproduces riboflavin, and it is currently exploited for the industrial production of this vitamin. The utilization of A. gossypii for biotechnological applications presents important advantages such as the utilization of low-cost culture media, inexpensive downstream processing and a wide range of molecular tools for genetic manipulation, thus making A. gossypii a valuable biotechnological chassis for metabolic engineering. A. gossypii has been shown to accumulate high levels of lipids in oil-based culture media; however, the lipid biosynthesis capacity is rather limited when grown in sugar-based culture media...
December 23, 2016: Microbial Biotechnology
https://www.readbyqxmd.com/read/27995760/enri-a-tool-for-selecting-structure-based-virtual-screening-target-conformations
#14
Rahmad Akbar, Siti Azma Jusoh, Rommie E Amaro, Volkhard Helms
Finding pharmaceutically relevant target conformations from an arbitrary set of protein conformations remains a challenge in structure-based virtual screening (SBVS). The growth in the number of available conformations, either experimentally determined or computationally derived, obscures the situation further. While the inflated conformation space potentially contains viable druggable targets, the increase of conformational complexity, as a consequence, poses a selection problem. To address this challenge, we took advantage of machine learning methods, namely an over-sampling and a binary classification procedure, and present a novel method to select druggable receptor conformations...
December 20, 2016: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/27991903/structural-basis-for-targeted-dna-cytosine-deamination-and-mutagenesis-by-apobec3a-and-apobec3b
#15
Ke Shi, Michael A Carpenter, Surajit Banerjee, Nadine M Shaban, Kayo Kurahashi, Daniel J Salamango, Jennifer L McCann, Gabriel J Starrett, Justin V Duffy, Özlem Demir, Rommie E Amaro, Daniel A Harki, Reuben S Harris, Hideki Aihara
APOBEC-catalyzed cytosine-to-uracil deamination of single-stranded DNA (ssDNA) has beneficial functions in immunity and detrimental effects in cancer. APOBEC enzymes have intrinsic dinucleotide specificities that impart hallmark mutation signatures. Although numerous structures have been solved, mechanisms for global ssDNA recognition and local target-sequence selection remain unclear. Here we report crystal structures of human APOBEC3A and a chimera of human APOBEC3B and APOBEC3A bound to ssDNA at 3.1-Å and 1...
December 19, 2016: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/27989803/folic-acid-production-by-engineered-ashbya-gossypii
#16
Cristina Serrano-Amatriain, Rodrigo Ledesma-Amaro, Rubén López-Nicolás, Gaspar Ros, Alberto Jiménez, José Luis Revuelta
Folic acid (vitamin B9) is the common name of a number of chemically related compounds (folates), which play a central role as cofactors in one-carbon transfer reactions. Folates are involved in the biosynthesis and metabolism of nucleotides and amino acids, as well as supplying methyl groups to a broad range of substrates, such as hormones, DNA, proteins, and lipids, as part of the methyl cycle. Humans and animals cannot synthesize folic acid and, therefore, need them in the diet. Folic acid deficiency is an important and underestimated problem of micronutrient malnutrition affecting billions of people worldwide...
October 28, 2016: Metabolic Engineering
https://www.readbyqxmd.com/read/27979361/-warming-up-with-endotrainer-prior-to-laparoscopic-cholecystectomy
#17
Alicia Troncoso-Bacelis, Jaime Soto-Amaro, Carlos Ramírez-Velázquez
BACKGROUND: Laparoscopic cholecystectomy is a safe and effective treatment and remains the gold standard in patients with benign disease. However it presents difficulties such as: the limited movement range of the instruments, the loss of depth perception, haptic feedback and the fulcrum effect. Previous training can optimize surgical performance in patients to master basic skills. OBJECTIVE: Assess the effectiveness of surgeons warming up with an endotrainer before performing laparoscopic cholecystectomy...
December 12, 2016: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/27977118/rapid-chagas-disease-drug-target-discovery-using-directed-evolution-in-drug-sensitive-yeast
#18
Sabine Ottilie, Gregory M Goldgof, Claudia Magalhaes Calvet, Gareth K Jennings, Greg LaMonte, Jake Schenken, Edgar Vigil, Prianka Kumar, Laura-Isobel McCall, Eduardo Soares Constantino Lopes, Felicia Gunawan, Jennifer Yang, Yo Suzuki, Jair L Siqueira-Neto, James H McKerrow, Rommie E Amaro, Larissa M Podust, Jacob D Durrant, Elizabeth A Winzeler
Recent advances in cell-based, high-throughput phenotypic screening have identified new chemical compounds that are active against eukaryotic pathogens. A challenge to their future development lies in identifying these compounds' molecular targets and binding modes. In particular, subsequent structure-based chemical optimization and target-based screening require a detailed understanding of the binding event. Here, we use directed evolution and whole-genome sequencing of a drug-sensitive S. cerevisiae strain to identify the yeast ortholog of TcCyp51, lanosterol-14-alpha-demethylase (TcCyp51), as the target of MMV001239, a benzamide compound with activity against Trypanosoma cruzi, the etiological agent of Chagas disease...
December 23, 2016: ACS Chemical Biology
https://www.readbyqxmd.com/read/27971620/cost-effectiveness-of-ranibizumab-compared-to-dexamethasone-in-patients-with-retinal-vein-occlusion-rvo-from-a-portuguese-health-care-perspective
#19
B Montóia, J Quintino, J P Castro Sousa, M Amaro, F Trindade, A S Almeida
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27935011/electrical-stimulation-with-non-implanted-electrodes-for-overactive-bladder-in-adults
#20
REVIEW
Fiona Stewart, Luis F Gameiro, Regina El Dib, Monica O Gameiro, Anil Kapoor, Joao L Amaro
BACKGROUND: Several options exist for managing overactive bladder (OAB), including electrical stimulation (ES) with non-implanted devices, conservative treatment and drugs. Electrical stimulation with non-implanted devices aims to inhibit contractions of the detrusor muscle, potentially reducing urinary frequency and urgency. OBJECTIVES: To assess the effects of ES with non-implanted electrodes for OAB, with or without urgency urinary incontinence, compared with: placebo or any other active treatment; ES added to another intervention compared with the other intervention alone; different methods of ES compared with each other...
December 9, 2016: Cochrane Database of Systematic Reviews
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