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https://www.readbyqxmd.com/read/28635541/association-between-abnormal-brain-functional-connectivity-in-children-and-psychopathology-a-study-based-on-graph-theory-and-machine-learning
#1
João Ricardo Sato, Claudinei Eduardo Biazoli, Giovanni Abrahão Salum, Ary Gadelha, Nicolas Crossley, Gilson Vieira, André Zugman, Felipe Almeida Picon, Pedro Mario Pan, Marcelo Queiroz Hoexter, Edson Amaro, Mauricio Anés, Luciana Monteiro Moura, Marco Antonio Gomes Del'Aquilla, Philip Mcguire, Luis Augusto Rohde, Euripedes Constantino Miguel, Andrea Parolin Jackowski, Rodrigo Affonseca Bressan
OBJECTIVES: One of the major challenges facing psychiatry is how to incorporate biological measures in the classification of mental health disorders. Many of these disorders affect brain development and its connectivity. In this study, we propose a novel method for assessing brain networks based on the combination of a graph theory measure (eigenvector centrality) and a one-class support vector machine (OC-SVM). METHODS: We applied this approach to resting-state fMRI data from 622 children and adolescents...
February 8, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28632168/a-comparative-study-of-the-structural-dynamics-of-four-terminal-uridylyl-transferases
#2
Kevin J Cheng, Özlem Demir, Rommie E Amaro
African trypanosomiasis occurs in 36 countries in sub-Saharan Africa with 10,000 reported cases annually. No definitive remedy is currently available and if left untreated, the disease becomes fatal. Structural and biochemical studies of trypanosomal terminal uridylyl transferases (TUTases) demonstrated their functional role in extensive uridylate insertion/deletion of RNA. Trypanosoma brucei RNA Editing TUTase 1 (TbRET1) is involved in guide RNA 3' end uridylation and maturation, while TbRET2 is responsible for U-insertion at RNA editing sites...
June 20, 2017: Genes
https://www.readbyqxmd.com/read/28628434/a-dermatosis-of-pregnancy
#3
Susana Brás, André Oliveira, Pedro Mendes-Bastos, Cristina Amaro
No abstract text is available yet for this article.
June 2017: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/28623426/comparative-physical-mapping-of-18s-rdna-in-the-karyotypes-of-six-leafcutter-ant-species-of-the-genera-atta-and-acromyrmex-formicidae-myrmicinae
#4
Gisele Amaro Teixeira, Luísa Antônia Campos Barros, Hilton Jeferson Alves Cardoso de Aguiar, Silvia das Graças Pompolo
Leafcutter ants of the Atta and Acromyrmex genera are important plagues in different cultures. Cytogenetic data on chromosome number, morphology, and chromosomal banding pattern are only available for 17 species of leafcutter ants. Molecular cytogenetic data for the detection of ribosomal genes by the FISH technique are scarce, and only 15 Neotropical ant species have been studied. This study aimed to physically map the 18S ribosomal RNA genes (rDNA) of six leafcutter ants belonging to the genera Atta and Acromyrmex using FISH...
June 16, 2017: Genetica
https://www.readbyqxmd.com/read/28610780/analysis-of-transcription-factors-micrornas-and-cytokines-involved-in-t-lymphocyte-differentiation-in-patients-with-tuberculosis-after-directly-observed-treatment-short-course
#5
Nancy Elizabeth Corral-Fernández, Juan Diego Cortes-García, Rivas-Santiago Bruno, Silvia Romano-Moreno, Susanna E Medellín-Garibay, Martín Magaña-Aquino, Raúl A Salazar-González, Roberto González-Amaro, Diana Patricia Portales-Pérez
Tuberculosis (Tb) is an infectious disease in which the immune system plays an important role. MicroRNAs are involved in the development and maintenance of CD4 + T lymphocyte subpopulations. miR-326 regulates the differentiation to Th17 cells and miR-29 correlates with the Th1 response. The aim of this study was to determine the role of microRNAs, Transcription Factors, and cytokines in Th differentiation before and after the directly observed treatment short-course (DOTS). Peripheral blood mononuclear cells and serum from Tb patients were collected at times 0 (before therapy), 2 (after the intensive phase), and 6 months (after the holding phase)...
July 2017: Tuberculosis
https://www.readbyqxmd.com/read/28605769/triatokey-a-web-and-mobile-tool-for-biodiversity-identification-of-brazilian-triatomine-species
#6
Luciana Márcia de Oliveira, Raissa Nogueira de Brito, Paul Anderson Souza Guimarães, Rômulo Vitor Mastrângelo Amaro Dos Santos, Liléia Gonçalves Diotaiuti, Rita de Cássia Moreira de Souza, Jeronimo Conceição Ruiz
http://triatokey.cpqrr.fiocruz.br.
January 1, 2017: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/28604710/erratum-conserved-patterns-hidden-within-group-a-streptococcus-m-protein-hypervariability-recognize-human-c4b-binding-protein
#7
Cosmo Z Buffalo, Adrian J Bahn-Suh, Sophia P Hirakis, Tapan Biswas, Rommie E Amaro, Victor Nizet, Partho Ghosh
This corrects the article DOI: 10.1038/nmicrobiol.2016.155.
June 12, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28604131/micronutrient-intake-and-the-contribution-of-dietary-supplements-in-hispanic-infants
#8
Kiara Amaro-Rivera, Andrea López-Cepero, Beatriz Diaz, Jae Eun Lee, Cristina Palacios
To calculate micronutrient adequacy among infants and toddlers and to determine the contribution of dietary supplements to this adequacy, micronutrient intake was assessed using two nonconsecutive 24-hour recalls in a sample of 296 infants aged 0-24 months. Micronutrient intake was calculated from foods and beverages and from supplements and compared between nonusers and users of supplements. Percentages of children below the Dietary Reference Intake (DRI) and above the tolerable upper limit intake (UL) were also compared between groups...
June 12, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28601436/evaluating-trace-element-bioavailability-and-potential-transfer-into-marine-food-chains-using-immobilised-diatom-model-species-phaeodactylum-tricornutum-on-king-george-island-antarctica
#9
Maria Teresa Cabrita, Ana Padeiro, Eduardo Amaro, Margarida Correia Dos Santos, Marcelo Leppe, Sergey Verkulich, Kevin A Hughes, Hans-Ulrich Peter, João Canário
In order to evaluate trace element bioavailability and potential transfer into marine food chains in human impacted areas of the Fildes Peninsula (King George Island, South Shetland Islands Archipelago), element levels (Cr, Ni, Cu, Zn, Cd, and Pb) were determined in water, sediments, phytoplankton, and in diatom Phaeodactylum tricornutum Bohlin (Bacillariophyceae) cells immobilised in alginate and exposed to water and sediments, from the Bellingshausen Dome (reference site) and Ardley Cove (human impacted area), during January 2014...
June 7, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28592680/chimpanzees-bonobos-and-children-successfully-coordinate-in-conflict-situations
#10
Alejandro Sánchez-Amaro, Shona Duguid, Josep Call, Michael Tomasello
Social animals need to coordinate with others to reap the benefits of group-living even when individuals' interests are misaligned. We compare how chimpanzees, bonobos and children coordinate their actions with a conspecific in a Snowdrift game, which provides a model for understanding how organisms coordinate and make decisions under conflict. In study 1, we presented pairs of chimpanzees, bonobos and children with an unequal reward distribution. In the critical condition, the preferred reward could only be obtained by waiting for the partner to act, with the risk that if no one acted, both would lose the rewards...
June 14, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28591716/adapting-alphalisa-high-throughput-screen-to-discover-a-novel-small-molecule-inhibitor-targeting-protein-arginine-methyltransferase-5-in-pancreatic-and-colorectal-cancers
#11
Lakshmi Prabhu, Han Wei, Lan Chen, Özlem Demir, George Sandusky, Emily Sun, John Wang, Jessica Mo, Lifan Zeng, Melissa Fishel, Ahmad Safa, Rommie Amaro, Murray Korc, Zhong-Yin Zhang, Tao Lu
Pancreatic ductal adenocarcinoma (PDAC) and colorectal cancer (CRC) are notoriously challenging for treatment. Hyperactive nuclear factor κB (NF-κB) is a common culprit in both cancers. Previously, we discovered that protein arginine methyltransferase 5 (PRMT5) methylated and activated NF-κB. Here, we show that PRMT5 is highly expressed in PDAC and CRC. Overexpression of PRMT5 promoted cancer progression, while shRNA knockdown showed an opposite effect. Using an innovative AlphaLISA high throughput screen, we discovered a lead compound, PR5-LL-CM01, which exhibited robust tumor inhibition effects in both cancers...
May 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28569219/hdl-cholesterol-efflux-capacity-in-rheumatoid-arthritis-patients-contributing-factors-and-relationship-with-subclinical-atherosclerosis
#12
Beatriz Tejera-Segura, María Macía-Díaz, José David Machado, Antonia de Vera-González, Jose A García-Dopico, José M Olmos, José L Hernández, Federico Díaz-González, Miguel A González-Gay, Iván Ferraz-Amaro
BACKGROUND: Lipid profiles appear to be altered in rheumatoid arthritis (RA) patients because of disease activity and inflammation. Cholesterol efflux capacity (CEC), which is the ability of high-density lipoprotein cholesterol to accept cholesterol from macrophages, has been linked not only to cardiovascular events in the general population but also to being impaired in patients with RA. The aim of this study was to establish whether CEC is related to subclinical carotid atherosclerosis in patients with RA...
May 31, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28558680/arginine-supplementation-modulates-pig-plasma-lipids-but-not-hepatic-fatty-acids-depending-on-dietary-protein-level-with-or-without-leucine
#13
Marta Sofia Morgado Dos Santos Madeira, Eva Sofia Alves Rolo, Virgínia Maria Rico Pires, Cristina Maria Riscado Pereira Mateus Alfaia, Diogo Francisco Maurício Coelho, Paula Alexandra Antunes Brás Lopes, Susana Isabel Vargas Martins, Rui Manuel Amaro Pinto, José António Mestre Prates
BACKGROUND: In the present study, the effect of arginine and leucine supplementation, and dietary protein level, were investigated in commercial crossbred pigs to clarify their individual or combined impact on plasma metabolites, hepatic fatty acid composition and mRNA levels of lipid sensitive factors. The experiment was conducted on fifty-four entire male pigs (Duroc × Pietrain × Large White × Landrace crossbred) from 59 to 92 kg of live weight. Each pig was randomly assigned to one of six experimental treatments (n = 9)...
May 30, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28549945/validity-of-the-rheumatoid-arthritis-impact-of-disease-raid-score-and-definition-of-cut-off-points-for-disease-activity-states-in-a-population-based-european-cohort-of-patients-with-rheumatoid-arthritis
#14
Fausto Salaffi, Marco Di Carlo, Jelena Vojinovic, Angela Tincani, Alberto Sulli, Stefano Soldano, Laura Andreoli, Francesca Dall'Ara, Ruxandra Ionescu, Katarina Simić Pašalić, Ineta Balčune, Iván Ferraz-Amaro, Malgorzata Tlustochowicz, Irena Butrimienė, Egle Punceviciene, Natalia Toroptsova, Simeon Grazio, Jadranka Morović-Vergles, Pavol Masaryk, Kati Otsa, Miguel Bernardes, Vladimira Boyadzhieva, Maurizio Cutolo
OBJECTIVES: To assess the validity of the Rheumatoid Arthritis Impact of Disease (RAID) for measuring disease activity of rheumatoid arthritis (RA), and to determine cut-off values for defining the disease activity states. METHODS: 622 RA patients from an European database have been included. Cross-validation was based on assessment of convergent and discriminant validity. Optimal cut-offs were determined against external criteria by calculating the respective 25(th) and 75(th) percentiles mean values of RAID...
May 23, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28541560/historical-analysis-the-journal-of-pediatric-psychology-from-1976-to-2015
#15
Kimberly S Canter, Christina M Amaro, Amy E Noser, Michael C Roberts
To provide a historical analysis through the examination of trends in type of articles, content areas, and population groups across all issues of the Journal of Pediatric Psychology (JPP). All articles published in JPP between the years 1976-2015 were coded based on article type (e.g., original research, meta-analysis), content code (e.g., adherence, primary care), and population code (e.g., oncology, chronic and recurrent pain). Descriptive statistics were calculated.  The overall top article types, content codes, and population codes are described as well as top codes for each decade...
May 25, 2017: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/28536684/gastrointestinal-cytomegalovirus-disease-in-a-patient-with-pemphigus-vulgaris-treated-with-corticosteroid-and-mycophenolate-mofetil
#16
Luiza Barbosa Oliveira, Celina Wakisaka Maruta, Denise Miyamoto, Fernanda Aburesi Salvadori, Claudia Giuli Santi, Valeria Aoki, Amaro Nunes Duarte-Neto
Pemphigus vulgaris is an autoimmune disease characterized by the formation of suprabasal intra-epidermal blisters on the skin and mucosal surfaces. Infectious diseases are the main cause of death in patients with pemphigus due to the disrupture of the physiological skin barrier, immune dysregulation, and the use of immunosuppressive medications leaving the patient prone to acquire opportunistic infections. We report the case of a 67-year-old woman diagnosed with pemphigus vulgaris, who was irregularly taking prednisone and mycophenolate mofetil...
January 2017: Autopsy & case reports
https://www.readbyqxmd.com/read/28528616/secondary-skin-plasmacytomas
#17
Pedro Mendes-Bastos, Susana Brás, Cristina Amaro, Jorge Cardoso
A 78-year old man was diagnosed in 2006 with IgAκ multiple myeloma (MM) (stage III-A). The patient was referred to our dermatology department in 2012 for evaluation of erythematous skin nodules on the anterior right aspect of the thorax; the skin lesions were noted during hospitalization for multiple bone fractures. He was on fourth-line chemotherapy (with vincristine/adriamycin/dexamethasone) because of constant disease progression. The patient was unaware of the skin lesions' evolution over time and did not recall when they had first appeared...
2017: Skinmed
https://www.readbyqxmd.com/read/28522256/sporadic-early-onset-diffuse-gastric-cancers-have-high-frequency-of-somatic-cdh1-alterations-but-low-frequency-of-somatic-rhoa-mutations-compared-with-late-onset-cancers
#18
Soo Young Cho, Jun Won Park, Yang Liu, Young Soo Park, Ju Hee Kim, Hanna Yang, Hyejin Um, Woo Ri Ko, Byung Il Lee, Sun Young Kwon, Seung Wan Ryu, Chae Hwa Kwon, Do Youn Park, Jae-Hyuk Lee, Sang Il Lee, Kyu Sang Song, Hoon Hur, Sang-Uk Han, Heekyung Chang, Su-Jin Kim, Byung-Sik Kim, Jeong-Hwan Yook, Moon-Won Yoo, Beom-Su Kim, In-Seob Lee, Myeong-Cherl Kook, Nina Thiessen, An He, Chip Stewart, Andrew Dunford, Jaegil Kim, Juliann Shih, Gordon Saksena, Andrew D Cherniack, Steven Schumacher, Amaro-Taylor Weiner, Mara Rosenberg, Gad Getz, Eun Gyeong Yang, Min Hee Ryu, Adam J Bass, Hark Kyun Kim
BACKGROUND & AIMS: Early-onset gastric cancer, which develops in younger patients than most gastric cancers, is usually detected at advanced stages, has diffuse histologic features, and occurs more frequently in women. We investigated somatic genomic alterations associated with the unique characteristics of sporadic diffuse gastric cancers (DGCs) from younger patients. METHODS: We conducted whole exome and RNA sequence analyses of 80 resected DGC samples from patients 45 years old or younger in Korea...
May 15, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28504363/allergic-contact-dermatitis-caused-by-meth-acrylates-in-nail-cosmetic-products-in-users-and-nail-technicians%C3%A2-%C3%A2-a-5-year-study
#19
Inês Raposo, Inês Lobo, Cristina Amaro, Maria de Lurdes Lobo, Helena Melo, Joana Parente, Teresa Pereira, Joana Rocha, Ana P Cunha, Armando Baptista, Pedro Serrano, Teresa Correia, Ana R Travassos, Margarida Dias, Fátima Pereira, Margarida Gonçalo
BACKGROUND: The increasing use of long-lasting nail aesthetic products has led to a growing number of cases of allergic contact dermatitis (ACD) caused by (meth)acrylates in recent years. OBJECTIVES: To provide information on ACD caused by (meth)acrylates related to nail cosmetic products. METHODS: We retrospectively reviewed files of patients with ACD caused by (meth)acrylates related to nail cosmetic products, who were patch tested between January 2011 and December 2015 in 13 departments of dermatology in Portugal...
May 15, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28475761/sugar-versus-fat-elimination-of-glycogen-storage-improves-lipid-accumulation-in-yarrowia-lipolytica
#20
Govindprasad Bhutada, Martin Kavšcek, Rodrigo Ledesma-Amaro, Stéphane Thomas, Gerald N Rechberger, Jean-Marc Nicaud, Klaus Natter
Triacylglycerol (TAG) and glycogen are the two major metabolites for carbon storage in most eukaryotic organisms. We investigated the glycogen metabolism of the oleaginous Yarrowia lipolytica and found that this yeast accumulates up to 16% glycogen in its biomass. Assuming that elimination of glycogen synthesis would result in an improvement of lipid accumulation, we characterized and deleted the single gene coding for glycogen synthase, YlGSY1. The mutant was grown under lipogenic conditions with glucose and glycerol as substrates and we obtained up to 60% improvement in TAG accumulation compared to the wild-type strain...
May 1, 2017: FEMS Yeast Research
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