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David Noiva Perdigoto, Pedro Amaro, Manuela Ferreira, Luis Tomé
A patient is admitted with complaints of recent onset nausea, discomfort, jaundice and blood tests that reveal severe hepatitis. At the time, she had been taking medication with Hypericum perforatum (St John's wort) for 6 months, and 6 weeks before this event, she took flupirtine maleate. A few days after being admitted, she developed encephalopathy progressing to acute liver failure (ALF) requiring unsuccessful liver transplantation. The patient was ultimately diagnosed with drug-induced liver injury (DILI)...
March 9, 2018: BMJ Case Reports
Cynthia M Amaro, Jose A Bello, Deepak Jain, Alexandra Ramnath, Carmen D'Ugard, Silvia Vanbuskirk, Eduardo Bancalari, Nelson Claure
OBJECTIVE: To evaluate in a randomized, double-blind, placebo-controlled trial the effect of early caffeine on the age of first successful extubation in preterm infants. STUDY DESIGN: Preterm infants born at 23-30 weeks of gestation requiring mechanical ventilation in the first 5 postnatal days were randomized to receive a 20 mg/kg loading dose followed by 5 mg/kg/day of caffeine or placebo until considered ready for extubation. The placebo group received a blinded loading dose of caffeine before extubation...
March 6, 2018: Journal of Pediatrics
Andrew R Crawford, Naji Alamuddin, Anastassia Amaro
PURPOSE OF REVIEW: We review recent studies discussing the impact of pharmacologic agents for weight loss on clinical cardiovascular events, as well as cardiometabolic risk factors. RECENT FINDINGS: Pharmacotherapy with current FDA-approved medications for weight loss can significantly improve known risk factors for the development of cardiovascular disease such as hypertension, hyperlipidemia, insulin resistance, inflammatory biomarkers, and the quantity of visceral fat, as well as non-alcoholic fatty liver disease...
March 6, 2018: Current Atherosclerosis Reports
Raúl Méndez, Rosario Menéndez, Catia Cillóniz, Isabel Amara-Elori, Rosanel Amaro, Paula González, Tomás Posadas, Alexandra Gimeno, Pedro P España, Jordi Almirall, Antoni Torres
RATIONALE: Assessment of the inflammatory response can help decision-making process when diagnosing community-acquired pneumonia (CAP), but there is a lack of information about the influence of time since onset of symptoms. We studied the impact of the number of days since onset of symptoms on inflammatory cytokines and biomarkers concentrations at CAP diagnosis in hospitalized patients. METHODS: We performed a secondary analysis in two prospective cohorts including 541 patients in the derivation cohort and 422 in the validation cohort...
March 6, 2018: American Journal of Respiratory and Critical Care Medicine
Karin Mente, Nancy A Edwards, Demelio Urbano, Abhik Ray-Chaudhury, Diego Iacono, Ana Tereza Di Lorenzo Alho, Eduardo Joaquim Lopes Alho, Edson Amaro, Silvina G Horovitz, Mark Hallett
BACKGROUND: The etiology of cervical dystonia is unknown. Cholinergic abnormalities have been identified in dystonia animal models and human imaging studies. Some animal models have cholinergic neuronal loss in the striatum and increased acetylcholinesterase activity in the pedunculopontine nucleus. OBJECTIVES: The objective of this study was to determine the presence of cholinergic abnormalities in the putamen and pedunculopontine nucleus in cervical dystonia human brain donors...
March 6, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
Barbara Barbosa Neves, Jaime R S Fonseca, Fausto Amaro, Adriano Pasqualotti
Older adults (aged 65+) are still less likely to adopt the Internet when compared to other age groups, although their usage is increasing. To explore the societal effects of Internet usage, scholars have been using social capital as an analytical tool. Social capital pertains to the resources that are potentially available in one's social ties. As the Internet becomes a prominent source of information, communication, and participation in industrialized countries, it is critical to study how it affects social resources from an age-comparative perspective...
2018: PloS One
Ignacio Amaro-Blanco, Pablo Tomás Fernández-Moreno, María Dolores Osuna-Ruiz, Fernando Bastida, Rafael De Prado
BACKGROUND: In perennial crops, the most common method of weed control is to spray herbicides, and glyphosate has long been the first choice of farmers. Three species of the genus Conyza are among the most problematic weeds for farmers, exhibiting resistance to glyphosate. The objectives of this work were to evaluate resistance levels and mechanisms, and to test chemical control alternatives in putative resistant (R) populations of Conyza bonariensis, Conyza canadensis and Conyza sumatrensis...
February 25, 2018: Pest Management Science
Marlon Amaro Coelho Teixeira, Kele Teixeira Belloze, Maria Cláudia Cavalcanti, Floriano P Silva-Junior
BACKGROUND AND OBJECTIVES: Semantic text annotation enables the association of semantic information (ontology concepts) to text expressions (terms), which are readable by software agents. In the scientific scenario, this is particularly useful because it reveals a lot of scientific discoveries that are hidden within academic articles. The Biomedical area has more than 300 ontologies, most of them composed of over 500 concepts. These ontologies can be used to annotate scientific papers and thus, facilitate data extraction...
April 2018: Computer Methods and Programs in Biomedicine
Alvaro Zinos-Amaro
No abstract text is available yet for this article.
February 22, 2018: Nature
Luiz Angelo Vieira, Aline Amaro Dos Santos, Carla Peluso, Caio Parente Barbosa, Bianca Bianco, Luciano Miller Reis Rodrigues
BACKGROUND: Intervertebral disc degeneration (DD) is an important cause of low back pain and its precise aetiology is not fully understood, being attributed to cumulative environmental, biomechanical and genetic effects. The vitamin D plays a key role in regulation of calcium homeostasis and bone mineralization, exerting its biological activities by binding to a high-affinity receptor (VDR). Polymorphisms in VDR gene were previously associated with DD process, however with conflicting results...
February 21, 2018: European Journal of Medical Research
Andrea Muras, Mario López-Pérez, Celia Mayer, Ana Parga, Jaime Amaro-Blanco, Ana Otero
There is increasing evidence being accumulated regarding the importance of N -acyl homoserine lactones (AHL)-mediated quorum-sensing (QS) and quorum-quenching (QQ) processes in the marine environment, but in most cases, data has been obtained from specific microhabitats, and subsequently little is known regarding these activities in free-living marine bacteria. The QS and QQ activities among 605 bacterial isolates obtained at 90 and 2000 m depths in the Mediterranean Sea were analyzed. Additionally, putative QS and QQ sequences were searched in metagenomic data obtained at different depths (15-2000 m) at the same sampling site...
February 16, 2018: Genes
Caio Átila Prata Bezerra Souza, Breytiner Amaro de Oliveira, Sacha Aubrey Alves Rodrigues Santos, Francisco Lucas Alves Batista, Francisco Regivânio Nascimento Andrade, Eugênio Januário Ramos Neto, José de Maria Albuquerque de Melo Júnior, Francisco Rogenio da Silva Mendes, Lana Karine Vasconcelos Barroso, Kirley Marques Canuto, Francisco Ernani Alves Magalhães, Angelo Roncalli Alves E Silva, Wladimir Ronald Lobo Farias, Adriana Rolim Campos
This study aimed to evaluate the antinociceptive effect of sulphated polysaccharide from the marine algae Hypnea pseudomusciformis (PLS) using rodent models of orofacial pain. Acute pain was induced by formalin, capsaicin, cinnamaldehyde, acidified saline or glutamate (cutaneous modes) and hypertonic saline (corneal model). In one experiment, animals were pretreated with ruthenium red, glibenclamide, naloxone, L-NAME, methylene blue or ketamine to investigate the mechanism of antinociception. In another experiment, animals pretreated with PLS or saline were submitted to the temporomandibular joint formalin test...
February 19, 2018: Inflammopharmacology
Ronaldo Luis Thomasini, Hortencia Gisele Amaro Souza, Oscar Bruna-Romero, Antonio Helvecio Totola, Neiva Sellan Lopes Gonçales, Cristiano Xavier Lima, Mauro Martins Teixeira
BACKGROUND: The most of the hepatitis C-infected patients remain undiagnosed until they develop severe liver damage or submitted for serological screening. OBJECTIVE: To evaluate a recombinant multiepitope protein for detection of IgG anti-hepatitis C virus. METHOD: A synthetic gene was cloned, expressed in Escherichia coli, and the recombinant protein was purified. Human serum panel consisted of 88 positives (20 HCV genotyped) and 376 negatives for hepatitis C, 6 positives for human acquired immunodeficiency virus, 6 syphilis positives, 6 hepatitis B positives were tested by IgG antihepatitis C virus using the protein by enzyme-linked immunosorbent assay...
February 17, 2018: Journal of Clinical Laboratory Analysis
Mariana Amaro, Francesco Reina, Martin Hof, Christian Eggeling, Erdinc Sezgin
Lipid packing is a crucial feature of cellular membranes. Quantitative analysis of membrane lipid packing can be achieved using polarity sensitive probes whose emission spectrum depends on the lipid packing. However, detailed insights into the exact mechanisms that cause the changes in the spectra are necessary to interpret experimental fluorescence emission data correctly. Here, we analysed frequently used polarity sensitive probes, Laurdan and di-4-ANEPPDHQ, to test whether the underlying physical mechanisms of their spectral changes are the same and, thus, whether they report on the same physico-chemical properties of the cell membrane...
April 5, 2017: Journal of Physics D: Applied Physics
Carlos Trapero, Esteban Alcántara, Jaime Jiménez, María C Amaro-Ventura, Joaquín Romero, Birger Koopmann, Petr Karlovsky, Andreas von Tiedemann, Mario Pérez-Rodríguez, Francisco J López-Escudero
This study investigated starch content, amount of pathogen DNA and density of occluded vessels in healthy and Verticillium dahliae infected olive shoots and stems. Starch hydrolysis is considered a mechanism to refill xylem vessels that suffered cavitation by either, drought conditions or pathogen infections. The main objective of this work was to evaluate this mechanism in olive plants subjected to V. dahliae infection or to drought conditions, in order to know the importance of cavitation in the development of wilting symptoms...
2018: Frontiers in Plant Science
Spencer C Evans, Christina M Amaro, Robyn Herbert, Jennifer B Blossom, Michael C Roberts
If a doctoral dissertation represents an original investigation that makes a contribution to one's field, then dissertation research could, and arguably should, be disseminated into the scientific literature. However, the extent and nature of dissertation publication remains largely unknown within psychology. The present study investigated the peer-reviewed publication outcomes of psychology dissertation research in the United States. Additionally, we examined publication lag, scientific impact, and variations across subfields...
2018: PloS One
F D Amaro, C M B Monteiro, J M F Dos Santos, A Antognini
This corrects the article DOI: 10.1038/srep41699.
February 12, 2018: Scientific Reports
Edith Elena Uresti-Rivera, Rocío Edith García-Jacobo, José Alfredo Méndez-Cabañas, Laura Elizabeth Gaytan-Medina, Nancy Cortez-Espinosa, Diana Patricia Portales-Pérez, Roberto González-Amaro, José Antonio Enciso-Moreno, Mariana Haydee García-Hernández
It has been reported that an increased function of the P2X7 purinergic receptor is associated with an increase in both insulin sensitivity and secretion. Accordingly, we explored the possible effect of the 1068 G>A polymorphism of the gene P2RX7 on glucose homeostasis and the levels of the anti-inflammatory cytokine IL-1Ra in T2D patients. The presence of the 1068 G>A polymorphism in T2D patients (n = 100) and healthy subjects (n = 100) was determined by DNA sequencing, and serum levels of IL-1Ra were measured by ELISA...
February 6, 2018: Gene
Alejandro Ramirez-Solis, Jorge Iván Amaro-Estrada, Jorge Hernández-Cobos, Laurent Maron
We report the results of Born-Oppenheimer molecular dynamics (BOMD) simulations on the aqueous solvation of the SmI3 molecule and of the bare Sm3+ cation at room temperature using the cluster microsolvation approach including 37 and 29 water molecules, respectively. The electronic structure calculations were done using the M062X hybrid exchange-correlation functional in conjunction with the 6-31G** basis sets for oxygen and hydrogen. For the iodine and samarium atoms, the Stuttgart-Köln relativistic effective-core potentials were utilized with their associated valence basis sets...
February 9, 2018: Inorganic Chemistry
Alison E Hunter-Smith, Zenon Rayter
Breast cancer is the most common cancer in women, worldwide, and 1,400 deaths per day are attributed to it. The success of national screening programs has seen breast cancers being diagnosed at an earlier stage. With conservative surgery to the breast demonstrating equivalent long-term outcomes, the last 10 years have seen a growing interest in the safety of less invasive management for the axilla in breast cancer patients. One-step nucleic acid amplification (OSNA) is a validated, reliable, and efficient tool in identifying micro- and macro-metastases intraoperatively...
2018: Breast Cancer: Targets and Therapy
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