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https://www.readbyqxmd.com/read/29310710/photobiomodulation-using-low-level-laser-therapy-lllt-for-patients-with-chronic-traumatic-brain-injury-a-randomized-controlled-trial-study-protocol
#1
Guilherme da Cruz Ribeiro Poiani, Ana Luiza Zaninotto, Ana Maria Costa Carneiro, Renato Amaro Zangaro, Afonso Shiguemi Inoue Salgado, Rodolfo Borges Parreira, Almir Ferreira de Andrade, Manoel Jacobsen Teixeira, Wellingson Silva Paiva
BACKGROUND: Photobiomodulation using low-level laser therapy (LLLT) has been tested as a new technique to optimize recovery of patients with traumatic brain injury (TBI). The aim of this study is to evaluate inhibitory attentional control after 18 sessions of active LLLT and compare with the placebo group (sham LLLT). Our exploratory analysis will evaluate the efficacy of the active LLLT on verbal and visuospatial episodic memory, executive functions (working memory, verbal and visuospatial fluency, attentional processes), and anxiety and depressive symptoms compared to the sham group...
January 8, 2018: Trials
https://www.readbyqxmd.com/read/29288952/effects-of-the-brain-derived-neurotropic-factor-variant-val66met-on-cortical-structure-in-late-childhood-and-early-adolescence
#2
Celia Maria de Araujo, Andre Zugman, Walter Swardfager, Sintia Iole Nogueira Belangero, Vanessa Kiyomi Ota, Leticia Maria Spindola, Hakon Hakonarson, Renata Pellegrino, Ary Gadelha, Giovanni Abrahão Salum, Pedro Mario Pan, Luciana Monteiro de Moura, Marco Del Aquilla, Felipe Almeida Picon, Edson Amaro, João Ricardo Sato, Elisa Brietzke, Rodrigo Grassi-Oliveira, Luis Augusto P Rohde, Euripedes Constantino Miguel, Rodrigo A Bressan, Andrea Parolin Jackowski
BACKGROUND: The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism (rs6265) has been associated with several neuropsychiatric disorders and regional structural brain changes in adults, but little is known about Val66Met's effect on brain morphology during typical or atypical neurodevelopment. Windows of vulnerability to psychopathology may be associated with the different alleles of the Val66Met polymorphism during childhood and adolescence. METHODOLOGY: We investigated the effect of Val66Met on cortical thickness in MRI scans of 718 children and adolescents (6-12 years old) with typical development, and in those meeting DSM criteria for a psychiatric disorder...
December 20, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29272950/reliability-assessment-for-large-scale-molecular-dynamics-approximations
#3
Francesca Grogan, Michael Holst, Lee Lindblom, Rommie Amaro
Molecular dynamics (MD) simulations are used in biochemistry, physics, and other fields to study the motions, thermodynamic properties, and the interactions between molecules. Computational limitations and the complexity of these problems, however, create the need for approximations to the standard MD methods and for uncertainty quantification and reliability assessment of those approximations. In this paper, we exploit the intrinsic two-scale nature of MD to construct a class of large-scale dynamics approximations...
December 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29260086/retinal-findings-in-membranoproliferative-glomerulonephritis
#4
Ahmad M Mansour, Luiz H Lima, J Fernando Arevalo, Miguel Hage Amaro, Virginia Lozano, Alaa Bou Ghannam, Errol W Chan
Purpose: To assess the evolution of retinal findings in patients with membranoproliferative glomerulonephritis (MPGN) by funduscopy, intravenous fluorescein angiography and optical coherence tomography. Observations: Three women and one man were followed for a period of 1.5-37 years. Four patients (8 eyes) had drusen detected at first fundus exam at age 24, 29, 50 and 55. Three patients (6 eyes) had diffuse thickening of Bruch's membrane, and two patients (3 eyes) had detachment of the retinal pigment epithelium with serous retinal detachment...
September 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29259186/mutational-patterns-in-chemotherapy-resistant-muscle-invasive-bladder-cancer
#5
David Liu, Philip Abbosh, Daniel Keliher, Brendan Reardon, Diana Miao, Kent Mouw, Amaro Weiner-Taylor, Stephanie Wankowicz, Garam Han, Min Yuen Teo, Catharine Cipolla, Jaegil Kim, Gopa Iyer, Hikmat Al-Ahmadie, Essel Dulaimi, David Y T Chen, R Katherine Alpaugh, Jean Hoffman-Censits, Levi A Garraway, Gad Getz, Scott L Carter, Joaquim Bellmunt, Elizabeth R Plimack, Jonathan E Rosenberg, Eliezer M Van Allen
Despite continued widespread use, the genomic effects of cisplatin-based chemotherapy and implications for subsequent treatment are incompletely characterized. Here, we analyze whole exome sequencing of matched pre- and post-neoadjuvant cisplatin-based chemotherapy primary bladder tumor samples from 30 muscle-invasive bladder cancer patients. We observe no overall increase in tumor mutational burden post-chemotherapy, though a significant proportion of subclonal mutations are unique to the matched pre- or post-treatment tumor, suggesting chemotherapy-induced and/or spatial heterogeneity...
December 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/29258951/use-of-photodynamic-therapy-in-the-treatment-of-bovine-subclinical-mastitis
#6
Lívia Helena Moreira, José Carlos Pereira de Souza, Carlos José de Lima, Miguel Angel Castillo Salgado, Adriana Barrinha Fernandes, Dora Inés Kozusny Andreani, Antonio Balbin Villaverde, Renato Amaro Zângaro
BACKGROUND: Bovine mastitis is a disease that causes a severe drawback in dairy production. Conventional treatments with antibiotic could leave antibiotic residues in the milk. The aim of this study was to evaluate the effect of photodynamic therapy in the treatment of bovine subclinical mastitis to develop an in vivo therapeutic protocol that could be used in routine farm practice, favoring the early return to production. METHODS: Forty cows with subclinical mastitis (n = 40) were divided into 4 groups (control, photodynamic therapy - PDT, light irradiation - LED, and photosensitizer - PS)...
December 16, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29239007/pemetrexed-induced-painful-erythematous-nodules-in-both-legs-in-a-patient-with-recurrent-mesothelioma
#7
Mar Llamas-Velasco, Enrique Ovejero-Merino, Javier Fraga, Amaro García-Diez, Ramón Moreno-Balsalobre
No abstract text is available yet for this article.
December 14, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29237239/sex-steroid-hormones-and-brain-function-pet-imaging-as-a-tool-for-research
#8
REVIEW
R Moraga-Amaro, A van Waarde, J Doorduin, E F J de Vries
Sex steroid hormones are major regulators of sexual characteristic among species. These hormones, however, are also produced in the brain. Steroidal hormone-mediated signaling via the corresponding hormone receptors can influence brain function at a cellular level and thus affect behavior and higher brain functions. Altered steroid hormone signaling has been associated with psychiatric disorders, such as anxiety and depression. Neurosteroids are also thought to have a neuroprotective effect in neurodegenerative diseases So far, the role of steroid hormone receptors in physiological and pathological conditions have mainly been investigated post-mortem on animal or human brain tissues...
December 13, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29236934/sensory-motor-training-versus-resistance-training-among-patients-with-knee-osteoarthritis-randomized-single-blind-controlled-trial
#9
Aline Bassoli Gomiero, Andrea Kayo, Marcelo Abraão, Maria Stella Peccin, Antonio Jose Grande, Virginia Fernandes Trevisani
BACKGROUND: Osteoarthritis of the knee is defined as a progressive disease of the synovial joints and is characterized by failure of joint damage repair. The objective here was to compare the effectiveness of sensory-motor training versus resistance training among patients with knee osteoarthritis. DESIGN AND SETTING: Randomized, single-blinded controlled trial conducted at the outpatient service of the University of Santo Amaro. METHODS: A total of 64 patients were randomly assigned to sensory-motor training or resistance training...
December 7, 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/29234622/impact-of-serum-tsh-and-anti-thyroglobulin-antibody-levels-on-lymph-node-fine-needle-aspiration-thyroglobulin-measurements-in-differentiated-thyroid-cancer-patients
#10
Marta Amaro da Silveira Duval, André Borsatto Zanella, Ana Patrícia Cristo, Carlo Sasso Faccin, Marcia Silva Graudenz, Ana Luiza Maia
Background: Thyroglobulin measurements in the washout of fine needle aspiration (FNA-Tg) are an excellent tool to detect lymph node (LN) metastases of differentiated thyroid carcinoma (DTC). Nevertheless, how to define the best cutoffs and the influence of potential confounders are still being discussed. Objective: To evaluate the accuracy of FNA-Tg measurement to detect DTC metastases and the influence of thyroid status and anti-thyroglobulin antibodies (TgAb)...
November 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29234087/conformational-switch-regulates-the-dna-cytosine-deaminase-activity-of-human-apobec3b
#11
Ke Shi, Özlem Demir, Michael A Carpenter, Jeff Wagner, Kayo Kurahashi, Reuben S Harris, Rommie E Amaro, Hideki Aihara
The APOBEC3B (A3B) single-stranded DNA (ssDNA) cytosine deaminase has important roles in innate immunity but is also a major endogenous source of mutations in cancer. Previous structural studies showed that the C-terminal catalytic domain of human A3B has a tightly closed active site, and rearrangement of the surrounding loops is required for binding to substrate ssDNA. Here we report structures of the A3B catalytic domain in a new crystal form that show alternative, yet still closed, conformations of active site loops...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29228316/identification-of-a-critical-window-for-ganciclovir-induced-disruption-of-testicular-development-in-rats
#12
Katlyn Barp Meyer, Anderson Joel Martino Andrade, Amanda Caroline Venturelli, Diogo Henrique Kita, Dária Louise Barbosa Machado, Rafaela Adams Philipsen, Alluanan Adelson do Nascimento Silva, Isabelle Cantão, Davyson Moreira, Valdemiro Amaro da Silva Junior, Taiza Stumpp, Rosana Nogueira Morais
Ganciclovir (GCV) has been implicated in the development of testicular alterations. Exposure on gestational day (GD) 10 in rats induced permanent effects, including focal reduction or absence of germ cells (Sertoli cell-only tubules). Because the timing of exposure can be critical for testicular effects, we exposed rat dams to 300 mg/kg GCV (three 100mg/kg subcutaneous injections) on GD10, 14 and 19, when germ cells have high rates of migration, proliferation and are mitotically quiescent, respectively. Males exposed to GCV in utero on GD10 and 14 were evaluated for androgenization markers, serum and fecal androgens, and testicular histomorphometry at adulthood...
December 7, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29219593/first-dark-matter-search-results-from-the-xenon1t-experiment
#13
E Aprile, J Aalbers, F Agostini, M Alfonsi, F D Amaro, M Anthony, F Arneodo, P Barrow, L Baudis, B Bauermeister, M L Benabderrahmane, T Berger, P A Breur, A Brown, A Brown, E Brown, S Bruenner, G Bruno, R Budnik, L Bütikofer, J Calvén, J M R Cardoso, M Cervantes, D Cichon, D Coderre, A P Colijn, J Conrad, J P Cussonneau, M P Decowski, P de Perio, P Di Gangi, A Di Giovanni, S Diglio, G Eurin, J Fei, A D Ferella, A Fieguth, W Fulgione, A Gallo Rosso, M Galloway, F Gao, M Garbini, R Gardner, C Geis, L W Goetzke, L Grandi, Z Greene, C Grignon, C Hasterok, E Hogenbirk, J Howlett, R Itay, B Kaminsky, S Kazama, G Kessler, A Kish, H Landsman, R F Lang, D Lellouch, L Levinson, Q Lin, S Lindemann, M Lindner, F Lombardi, J A M Lopes, A Manfredini, I Mariş, T Marrodán Undagoitia, J Masbou, F V Massoli, D Masson, D Mayani, M Messina, K Micheneau, A Molinario, K Morå, M Murra, J Naganoma, K Ni, U Oberlack, P Pakarha, B Pelssers, R Persiani, F Piastra, J Pienaar, V Pizzella, M-C Piro, G Plante, N Priel, L Rauch, S Reichard, C Reuter, B Riedel, A Rizzo, S Rosendahl, N Rupp, R Saldanha, J M F Dos Santos, G Sartorelli, M Scheibelhut, S Schindler, J Schreiner, M Schumann, L Scotto Lavina, M Selvi, P Shagin, E Shockley, M Silva, H Simgen, M V Sivers, A Stein, S Thapa, D Thers, A Tiseni, G Trinchero, C Tunnell, M Vargas, N Upole, H Wang, Z Wang, Y Wei, C Weinheimer, J Wulf, J Ye, Y Zhang, T Zhu
We report the first dark matter search results from XENON1T, a ∼2000-kg-target-mass dual-phase (liquid-gas) xenon time projection chamber in operation at the Laboratori Nazionali del Gran Sasso in Italy and the first ton-scale detector of this kind. The blinded search used 34.2 live days of data acquired between November 2016 and January 2017. Inside the (1042±12)-kg fiducial mass and in the [5,40]  keV_{nr} energy range of interest for weakly interacting massive particle (WIMP) dark matter searches, the electronic recoil background was (1...
November 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29216878/adaptive-phenotype-drives-resistance-to-androgen-deprivation-therapy-in-prostate-cancer
#14
Nicoletta Ferrari, Ilaria Granata, Matteo Capaia, Marina Piccirillo, Mario Rosario Guarracino, Roberta Venè, Antonella Brizzolara, Andrea Petretto, Elvira Inglese, Martina Morini, Simonetta Astigiano, Adriana Agnese Amaro, Francesco Boccardo, Cecilia Balbi, Paola Barboro
BACKGROUND: Prostate cancer (PCa), the second most common cancer affecting men worldwide, shows a broad spectrum of biological and clinical behaviour representing the epiphenomenon of an extreme heterogeneity. Androgen deprivation therapy is the mainstay of treatment for advanced forms but after few years the majority of patients progress to castration-resistant prostate cancer (CRPC), a lethal form that poses considerable therapeutic challenges. METHODS: Western blotting, immunocytochemistry, invasion and reporter assays, and in vivo studies were performed to characterize androgen resistant sublines phenotype in comparison to the parental cell line LNCaP...
December 8, 2017: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/29204945/d3r-grand-challenge-2-blind-prediction-of-protein-ligand-poses-affinity-rankings-and-relative-binding-free-energies
#15
Zied Gaieb, Shuai Liu, Symon Gathiaka, Michael Chiu, Huanwang Yang, Chenghua Shao, Victoria A Feher, W Patrick Walters, Bernd Kuhn, Markus G Rudolph, Stephen K Burley, Michael K Gilson, Rommie E Amaro
The Drug Design Data Resource (D3R) ran Grand Challenge 2 (GC2) from September 2016 through February 2017. This challenge was based on a dataset of structures and affinities for the nuclear receptor farnesoid X receptor (FXR), contributed by F. Hoffmann-La Roche. The dataset contained 102 IC50 values, spanning six orders of magnitude, and 36 high-resolution co-crystal structures with representatives of four major ligand classes. Strong global participation was evident, with 49 participants submitting 262 prediction submission packages in total...
December 4, 2017: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/29204336/sporotrichosis-by-sporothrix-schenckii-senso-stricto-with-itraconazole-resistance-and-terbinafine-sensitivity-observed-in-vitro-and-in-vivo-case-report
#16
Rodrigo Vettorato, Daiane Heidrich, Fernanda Fraga, Amanda Carvalho Ribeiro, Danielle Machado Pagani, Carina Timotheo, Tais Guarienti Amaro, Gerson Vettorato, Maria Lúcia Scroferneker
We report a case of a patient with lymphocutaneous sporotrichosis in the right upper limb. The fungus was identified as Sporothrix schenckii senso stricto by calmodulin gene sequencing. The initial treatment was itraconazole (200 mg/day), but in vitro antifungal susceptibility demonstrated high resistant to this and another six antifungals, with exception to terbinafine. The lesions did not regress with itraconazole treatment. Thus, 500 mg/day of terbinafine was prescribed and clinical cure was obtained after four months...
March 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29184012/fatal-colitis-associated-with-active-systemic-lupus-erythematosus-complicated-by-cytomegalovirus-superinfection
#17
Elisa Gravito-Soares, Marta Gravito-Soares, Maria Augusta Cipriano, Pedro Amaro
No abstract text is available yet for this article.
November 28, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29182553/coumarin-derivatives-solvent-free-synthesis-under-microwave-irradiation-over-heterogeneous-solid-catalysts
#18
Souad Bouasla, Juan Amaro-Gahete, Dolores Esquivel, M Isabel López, César Jiménez-Sanchidrián, Mabrouk Teguiche, Francisco J Romero-Salguero
A suitable methodology of synthesis of coumarin derivatives by Pechmann reaction over heterogeneous solid acid catalysts in a free solvent media under microwave irradiation is described. Resorcinol, phenol and ethyl acetoacetate were selected as model reactants in the Pechmann condensation. The catalytic activity of several materials-Amberlyst-15, zeolite β and sulfonic acid functionalized hybrid silica-in solvent-free microwave-assisted synthesis of the corresponding coumarin derivatives has been investigated in detail...
November 28, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29176874/neurturin-overexpression-in-dopaminergic-neurons-induces-presynaptic-and-postsynaptic-structural-changes-in-rats-with-chronic-6-hydroxydopamine-lesion
#19
David Reyes-Corona, Nallely Vázquez-Hernández, Lourdes Escobedo, Carlos E Orozco-Barrios, Jose Ayala-Davila, Mario Gil Moreno, Miriam E Amaro-Lara, Yazmin M Flores-Martinez, Armando J Espadas-Alvarez, Manuel A Fernandez-Parrilla, Juan A Gonzalez-Barrios, M E Gutierrez-Castillo, Ignacio González-Burgos, Daniel Martinez-Fong
The structural effect of neurturin (NRTN) on the nigrostriatal dopaminergic system in animals remains unknown, although NRTN has been shown to be effective in Parkinson's disease animal models. Herein, we aimed to demonstrate that NRTN overexpression in dopaminergic neurons stimulates both neurite outgrowths in the nigrostriatal pathway and striatal dendritic spines in aging rats with chronic 6-hydroxydopamine (6-OHDA) lesion. At week 12 after lesion, pTracer-mNRTN-His or pGreenLantern-1 plasmids were intranigrally transfected using the NTS-polyplex nanoparticles system...
2017: PloS One
https://www.readbyqxmd.com/read/29174569/a-modified-poisson-boltzmann-equation-applied-to-protein-adsorption
#20
Marlon de Souza Gama, Mirella Simões Santos, Eduardo Rocha de Almeida Lima, Frederico Wanderley Tavares, Amaro Gomes Barreto Barreto
Ion-exchange chromatography has been widely used as a standard process in purification and analysis of protein, based on the electrostatic interaction between the protein and the stationary phase. Through the years, several approaches are used to improve the thermodynamic description of colloidal particle-surface interaction systems, however there are still a lot of gaps specifically when describing the behavior of protein adsorption. Here, we present an improved methodology for predicting the adsorption equilibrium constant by solving the modified Poisson-Boltzmann (PB) equation in bispherical coordinates...
November 13, 2017: Journal of Chromatography. A
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