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https://www.readbyqxmd.com/read/28444102/pet-mri-a-novel-hybrid-imaging-technique-major-clinical-indications-and-preliminary-experience-in-brazil
#1
Taise Vitor, Karine Minaif Martins, Tudor Mihai Ionescu, Marcelo Livorsi da Cunha, Ronaldo Hueb Baroni, Marcio Ricardo Taveira Garcia, Jairo Wagner, Guilherme de Carvalho Campos, Solange Amorim Nogueira, Elaine Gonçalves Guerra, Edson Amaro
In recent years, medical imaging with hybrid techniques has widely accepted and employed in clinical routine. PET/MRI offers significant advantages, including excellent contrast and resolution and reduced ionizing radiation, as compared to well-established PET/CT. Therefore, PET/MRI is a promising modality for oncologic imaging of some regions, such as brain, head and neck, liver and pelvis. This article set out to analyze clinical conditions that could benefit from PET/MRI imaging based on our caseload. The potential of PET/MRI to become the imaging modality of choice for assessment of neurologic and oncologic conditions associated with soft tissues is highlighted...
January 2017: Einstein
https://www.readbyqxmd.com/read/28444083/interictal-abnormal-fmri-activation-of-visual-areas-during-a-motor-task-cued-by-visual-stimuli-in-migraine
#2
Adriana Bastos Conforto, Khallil Taverna Chaim, Mario Fernando Prieto Peres, André Leite Gonçalves, Inara Laurindo Siqueira, Maria Angela Maramaldo Barreiros, Edson Amaro
Objective: To assess changes in blood-oxygen-level-dependent activity after light deprivation compared to regular light exposure in subjects with migraine in the interictal state and in controls. Methods: Ten subjects with migraine and ten controls participated in two sessions of functional magnetic resonance imaging. In each session, they performed a finger-tapping task with the right hand, cued by visual stimuli. They were scanned before and after 30 minutes of light deprivation or light exposure...
January 2017: Einstein
https://www.readbyqxmd.com/read/28433850/surgical-resection-and-histopathological-analysis-of-a-thrombosed-giant-fusiform-mca-aneurysm-after-initial-treatment-with-a-flow-diversion-construct
#3
Jayson Sack, Vincent Cheung, Deirdre Amaro, Arvin R Wali, David R Santiago-Dieppa, J Scott Pannell, Alexander A Khalessi
BACKGROUND: We describe the histopathology of an un-ruptured, giant calcified left MCA fusiform aneurysm initially treated with endovascular flow diversion. The flow diversion construct underwent post-operative in-stent thrombosis, necessitating surgical resection of the aneurysm to eliminate mass effect. METHODS: A 75-year-old woman with a known left MCA aneurysm presented to the Emergency Department with moderate right hemibody weakness. Due to the clinical and radiographic progression of the aneurysm, the patient was offered treatment...
April 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28427019/transplantation-of-inhibitory-precursor-cells-from-medial-ganglionic-eminence-produces-distinct-responses-in-two-different-models-of-acute-seizure-induction
#4
Daisyléa de Souza Paiva, Simone Amaro Alves Romariz, Maria Fernanda Valente, Luiz Bruno Moraes, Luciene Covolan, Maria Elisa Calcagnotto, Beatriz Monteiro Longo
Medial ganglionic eminence (MGE) is one of the sources of inhibitory interneurons during development. Following transplantation in postnatal developing brain, MGE cells can increase local inhibition suggesting a possible protection to GABAergic dysfunction in brain disorders, such as epilepsy. Since it has been shown that MGE-derived cells harvested as neurospheres are able to suppress seizures, it might be important to investigate whether these protective effects would change in different seizure models. Here, we used pentylenetetrazole-(PTZ) and maximal electroshock (MES)-induced seizure models to test whether the transplantation of MGE cells would increase the threshold to trigger acute seizures...
April 17, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28423903/biography-of-klaus-schulten
#5
Rommie E Amaro, Elizabeth Villa, Zan Luthey-Schulten
No abstract text is available yet for this article.
April 20, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28419951/can-fractal-methods-applied-to-video-tracking-detect-the-effects-of-deltamethrin-pesticide-or-mercury-on-the-locomotion-behavior-of-shrimps
#6
Bruno Mendes Tenorio, Eurípedes Alves da Silva Filho, Gentileza Santos Martins Neiva, Valdemiro Amaro da Silva, Fernanda das Chagas Angelo Mendes Tenorio, Themis de Jesus da Silva, Emerson Carlos Soares E Silva, Romildo de Albuquerque Nogueira
Shrimps can accumulate environmental toxicants and suffer behavioral changes. However, methods to quantitatively detect changes in the behavior of these shrimps are still needed. The present study aims to verify whether mathematical and fractal methods applied to video tracking can adequately describe changes in the locomotion behavior of shrimps exposed to low concentrations of toxic chemicals, such as 0.15µgL(-1) deltamethrin pesticide or 10µgL(-1) mercuric chloride. Results showed no change after 1min, 4, 24, and 48h of treatment...
April 15, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28419226/sugar-versus-fat-elimination-of-glycogen-storage-improves-lipid-accumulation-in-yarrowia-lipolytica
#7
Govindprasad Bhutada, Martin Kavšcek, Rodrigo Ledesma-Amaro, Stéphane Thomas, Gerald N Rechberger, Jean-Marc Nicaud, Klaus Natter
Triacylglycerol (TAG) and glycogen are the two major metabolites for carbon storage in most eukaryotic organisms. We investigated the glycogen metabolism of the oleaginous Y. lipolytica and found that this yeast accumulates up to 16% glycogen in its biomass. Assuming that elimination of glycogen synthesis would result in an improvement of lipid accumulation, we characterized and deleted the single gene coding for glycogen synthase, YlGSY1. The mutant was grown under lipogenic conditions with glucose and glycerol as substrates and we obtained up to 60% improvement in TAG accumulation compared to the wild type strain...
April 17, 2017: FEMS Yeast Research
https://www.readbyqxmd.com/read/28410623/impact-of-gm1-on-membrane-mediated-aggregation-oligomerization-of-%C3%AE-amyloid-unifying-view
#8
REVIEW
Marek Cebecauer, Martin Hof, Mariana Amaro
In this perspective we summarize current knowledge of the effect of monosialoganglioside GM1 on the membrane-mediated aggregation of the β-amyloid (Aβ) peptide. GM1 has been suggested to be actively involved in the development of Alzheimer's disease due to its ability to seed the aggregation of Aβ. However, GM1 is known to be neuroprotective against Aβ-induced toxicity. Here we suggest that the two scenarios are not mutually exclusive but rather complementary, and might depend on the organization of GM1 in membranes...
April 11, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28398804/four-priorities-to-guide-a-public-health-of-consequence
#9
Hortensia Amaro
No abstract text is available yet for this article.
May 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28394025/quantitative-analysis-of-the-tomato-nuclear-proteome-during-phytophthora-capsici-infection-unveils-regulators-of-immunity
#10
Andrew J M Howden, Remco Stam, Victor Martinez Heredia, Graham B Motion, Sara Ten Have, Kelly Hodge, Tiago M Marques Monteiro Amaro, Edgar Huitema
Plant-pathogen interactions are complex associations driven by the interplay of host and microbe-encoded factors. With secreted pathogen proteins (effectors) and immune signalling components found in the plant nucleus, this compartment is a battleground where susceptibility is specified. We hypothesized that, by defining changes in the nuclear proteome during infection, we can pinpoint vital components required for immunity or susceptibility. We tested this hypothesis by documenting dynamic changes in the tomato (Solanum lycopersicum) nuclear proteome during infection by the oomycete pathogen Phytophthora capsici...
April 10, 2017: New Phytologist
https://www.readbyqxmd.com/read/28392743/stability-of-plasma-electrolytes-in-barricor-and-pst-ii-tubes-under-different-storage-conditions
#11
Luis Alfredo Bautista Balbás, Marta Segovia Amaro, Rubén Gómez Rioja, María José Alcaide Martín, Antonio Buńo Soto
INTRODUCTION: Sample stability can be influenced by many different factors; evaporation and leakage from residual cells are the most relevant factors for electrolytes. During the analytical phase, samples are usually kept uncapped at room temperature. Once samples are processed, they are usually stored sealed and refrigerated. Long turnaround time and the possibility of "add-on test" need consideration for electrolyte stability. The aim of our study is to examine short-term electrolyte stability in this two-common laboratory working conditions in two different lithium heparin plasma tubes (Barricor and PST II, Becton Dickinson)...
February 15, 2017: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/28385048/a-new-alkaloid-and-flavonoids-isolated-from-solanum-cernuum-leaves-by-high-performance-countercurrent-chromatography
#12
Amaro Chaves Ramos, Rodrigo Rodrigues de Oliveira
Solanum cernuum is a medicinal plant widely distributed in south-east regions of Brazil and popularly used to treat several disorders. Despite their utilisation as a medicine, few studies on its chemical composition are reported. An efficient separation method for the ethyl acetate fraction was developed by high-performance countercurrent chromatography using n-butanol/chloroform/methanol/water (3:7:3:4, v/v/v/v) as the solvent system, affording five compounds (1-5) in one-step separation. A new cyclic guanidine alkaloid named cernidine (5) was obtained, besides four glycosylated flavonoids: afzelin (1), astragalin (2), kaempferol 3-O-α[apiofuranosyl-(1 → 2)]-α-rhamnopyranoside (3) and kaempferol 3-O-α[apiofuranosyl-(1→2)]-β-galactopyranoside (4)...
April 7, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28382461/longitudinal-predictors-of-intimate-partner-violence-perpetration-and-victimization-in-latino-emerging-adults
#13
Carolina Villamil Grest, Hortensia Amaro, Jennifer Unger
Despite the prevalence of intimate partner violence in emerging adulthood, literature focused on this life stage among Latinos remains limited. This longitudinal study examined acculturation; traditional gender role attitudes; use of alcohol, marijuana, and tobacco; and depressive symptoms in 10th grade as predictors of intimate partner violence perpetration and victimization among Latino emerging adults (N = 823; 58% female). Average age of participants was 15.5 years in 10th grade and 22.7 years in emerging adulthood...
April 5, 2017: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/28378397/relationship-among-lrp1-expression-pyk2-phosphorylation-and-mmp-9-activation-in-left-ventricular-remodelling-after-myocardial-infarction
#14
Elena Revuelta-López, Carol Soler-Botija, Laura Nasarre, Aleyda Benitez-Amaro, David de Gonzalo-Calvo, Antoni Bayes-Genis, Vicenta Llorente-Cortés
Left ventricular (LV) remodelling after myocardial infarction (MI) is a crucial determinant of the clinical course of heart failure. Matrix metalloproteinase (MMP) activation is strongly associated with LV remodelling after MI. Elucidation of plasma membrane receptors related to the activation of specific MMPs is fundamental for treating adverse cardiac remodelling after MI. The aim of current investigation was to explore the potential association between the low-density lipoprotein receptor-related protein 1 (LRP1) and MMP-9 and MMP-2 spatiotemporal expression after MI...
April 4, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28358484/structure-determination-and-mechanism-of-formation-of-a-seco-moreliane-derivative-supported-by-computational-analysis
#15
Pablo A Chacón Morales, Juan M Amaro-Luis, Andrei G Kutateladze
Basic hydrolysis of a dichloromethane extract of Stevia lucida yielded (4R,5S,7R,9R,10R,11R)-7,9-dihydroxylongipin-2-en-1-one (1), which was oxidized and subjected to acidic conditions to generate the new seco-moreliane derivative 3. The structure of 3 was established based on NMR data interpretation and confirmed computationally. A plausible mechanism for the carbocationic rearrangement of the trione 2 to the seco-moreliane 3 was supported by DFT computations.
March 30, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28339273/search-for-electronic-recoil-event-rate-modulation-with-4-years-of-xenon100-data
#16
E Aprile, J Aalbers, F Agostini, M Alfonsi, F D Amaro, M Anthony, F Arneodo, P Barrow, L Baudis, B Bauermeister, M L Benabderrahmane, T Berger, P A Breur, A Brown, E Brown, S Bruenner, G Bruno, R Budnik, L Bütikofer, J Calvén, J M R Cardoso, M Cervantes, D Cichon, D Coderre, A P Colijn, J Conrad, J P Cussonneau, M P Decowski, P de Perio, P Di Gangi, A Di Giovanni, S Diglio, G Eurin, J Fei, A D Ferella, A Fieguth, D Franco, W Fulgione, A Gallo Rosso, M Galloway, F Gao, M Garbini, C Geis, L W Goetzke, Z Greene, C Grignon, C Hasterok, E Hogenbirk, R Itay, B Kaminsky, G Kessler, A Kish, H Landsman, R F Lang, D Lellouch, L Levinson, Q Lin, S Lindemann, M Lindner, J A M Lopes, A Manfredini, I Maris, T Marrodán Undagoitia, J Masbou, F V Massoli, D Masson, D Mayani, M Messina, K Micheneau, B Miguez, A Molinario, M Murra, J Naganoma, K Ni, U Oberlack, P Pakarha, B Pelssers, R Persiani, F Piastra, J Pienaar, V Pizzella, M-C Piro, G Plante, N Priel, L Rauch, S Reichard, C Reuter, A Rizzo, S Rosendahl, N Rupp, J M F Dos Santos, G Sartorelli, M Scheibelhut, S Schindler, J Schreiner, M Schumann, L Scotto Lavina, M Selvi, P Shagin, M Silva, H Simgen, M V Sivers, A Stein, D Thers, A Tiseni, G Trinchero, C Tunnell, H Wang, Y Wei, C Weinheimer, J Wulf, J Ye, Y Zhang
We report on a search for electronic recoil event rate modulation signatures in the XENON100 data accumulated over a period of 4 yr, from January 2010 to January 2014. A profile likelihood method, which incorporates the stability of the XENON100 detector and the known electronic recoil background model, is used to quantify the significance of periodicity in the time distribution of events. There is a weak modulation signature at a period of 431_{-14}^{+16} day in the low energy region of (2.0-5.8) keV in the single scatter event sample, with a global significance of 1...
March 10, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28336041/double-edged-sword-musculoskeletal-infection-provoked-acute-phase-response-in-children
#17
REVIEW
Michael Benvenuti, Thomas An, Emilie Amaro, Steven Lovejoy, Gregory Mencio, Jeffrey Martus, Megan Mignemi, Jonathan G Schoenecker
The acute phase response has a crucial role in mounting the body's response to tissue injury. Excessive activation of the acute phase response is responsible for many complications that occur in orthopedic patients. Given that infection may be considered continuous tissue injury that persistently activates the acute phase response, children with musculoskeletal infections are at markedly increased risk for serious complications. Future strategies that modulate the acute phase response have the potential to improve treatment and prevent complications associated with musculoskeletal infection...
April 2017: Orthopedic Clinics of North America
https://www.readbyqxmd.com/read/28332257/exomic-variants-of-an-elderly-cohort-of-brazilians-in-the-abraom%C3%A2-database
#18
Michel Satya Naslavsky, Guilherme Lopes Yamamoto, Tatiana Ferreira de Almeida, Suzana A M Ezquina, Daniele Yumi Sunaga, Nam Pho, Daniel Bozoklian, Tatiana Orli Milkewitz Sandberg, Luciano Abreu Brito, Monize Lazar, Danilo Vicensotto Bernardo, Edson Amaro, Yeda A O Duarte, Maria Lúcia Lebrão, Maria Rita Passos-Bueno, Mayana Zatz
Brazilians are highly admixed with ancestry from Europe, Africa, America, and Asia yet still underrepresented in genomic databanks. We hereby present a collection of exomic variants from 609 elderly Brazilians in a census-based cohort (SABE609) with comprehensive phenotyping. Variants were deposited in ABraOM (Online Archive of Brazilian Mutations), a web-based public database. Population representative phenotype and genotype repositories are essential for variant interpretation through allele frequency filtering; since elderly individuals are less likely to harbor pathogenic mutations for early and adult-onset diseases, such variant databases are of great interest...
March 23, 2017: Human Mutation
https://www.readbyqxmd.com/read/28323473/video-based-grocery-shopping-intervention-effect-on-purchasing-behaviors-among-latina-shoppers
#19
Hortensia Amaro, Dharma E Cortés, Samantha Garcia, Lei Duan, David S Black
OBJECTIVES: To compare changes in food-purchasing knowledge, self-efficacy, and behavior after viewing nutrition education videos among Los Angeles, California Latinas responsible for household grocery shopping. METHODS: From February to May 2015, a convenience sample of 113 Latinas watched 1 video (El Carrito Saludable) featuring MyPlate guidelines applied to grocery shopping (1-video intervention) and another convenience sample of 105 Latinas watched 2 videos (El Carrito Saludable and Ser Consciente), the latter featuring mindfulness to support attention and overcome distractions while grocery shopping (2-video intervention)...
May 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28319239/mobile-health-interventions-for-improving-health-outcomes-in-youth-a-meta-analysis
#20
David A Fedele, Christopher C Cushing, Alyssa Fritz, Christina M Amaro, Adrian Ortega
Importance: Mobile health interventions are increasingly popular in pediatrics; however, it is unclear how effective these interventions are in changing health outcomes. Objective: To determine the effectiveness of mobile health interventions for improving health outcomes in youth 18 years or younger. Data Sources: Studies published through November 30, 2016, were collected through PubMed, Cumulative Index to Nursing and Allied Health Literature, Educational Resources Information Center, and PsychINFO...
March 20, 2017: JAMA Pediatrics
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