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https://www.readbyqxmd.com/read/29780279/relativistic-dynamics-and-extreme-mass-ratio-inspirals
#1
Pau Amaro-Seoane
It is now well-established that a dark, compact object, very likely a massive black hole (MBH) of around four million solar masses is lurking at the centre of the Milky Way. While a consensus is emerging about the origin and growth of supermassive black holes (with masses larger than a billion solar masses), MBHs with smaller masses, such as the one in our galactic centre, remain understudied and enigmatic. The key to understanding these holes-how some of them grow by orders of magnitude in mass-lies in understanding the dynamics of the stars in the galactic neighbourhood...
2018: Living Reviews in Relativity
https://www.readbyqxmd.com/read/29756855/post-newtonian-dynamics-in-dense-star-clusters-highly-eccentric-highly-spinning-and-repeated-binary-black-hole-mergers
#2
Carl L Rodriguez, Pau Amaro-Seoane, Sourav Chatterjee, Frederic A Rasio
We present models of realistic globular clusters with post-Newtonian dynamics for black holes. By modeling the relativistic accelerations and gravitational-wave emission in isolated binaries and during three- and four-body encounters, we find that nearly half of all binary black hole mergers occur inside the cluster, with about 10% of those mergers entering the LIGO/Virgo band with eccentricities greater than 0.1. In-cluster mergers lead to the birth of a second generation of black holes with larger masses and high spins, which, depending on the black hole natal spins, can sometimes be retained in the cluster and merge again...
April 13, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29746624/contemporary-evaluation-of-breast-lymph-nodes-in-anatomic-pathology
#3
Beth T Harrison, Jane E Brock
Objectives: Management of the axilla in breast cancer patients has evolved considerably since the introduction of the sentinel lymph node (SLN) biopsy in the 1990s. Several new clinical and technological developments in the last decade warrant special consideration due to their impact on pathology practice. Methods: This review covers the SLN biopsy procedure, issues in the histopathologic and molecular diagnosis of the SLN, and most importantly, evidence from recent practice-changing clinical trials...
May 9, 2018: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29742215/first-brazilian-datathon-in-critical-care
#4
Ary Serpa Neto, Guillaume Kugener, Lucas Bulgarelli, Roberto Rabello Filho, Miguel Ángel Armengol de la Hoz, Alistair Ew Johnson, Kenneth E Paik, Felipe Torres, Chen Xie, Edson Amaro Júnior, Leonardo José Rolim Ferraz, Leo Anthony Celi, Rodrigo Octavio Deliberato
No abstract text is available yet for this article.
March 2018: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/29736731/phthalimido-thiazole-as-privileged-scaffold-activity-against-immature-and-adult-worms-of-schistosoma-mansoni
#5
Sheilla Andrade de Oliveira, Miria de Oliveira Barbosa, Carlos André Laranjeira Miranda Filho, Arsênio Rodrigues Oliveira, Fabiano Amaro de Sousa, Edna de Farias Santiago, Gevanio Bezerra de Oliveira Filho, Paulo André Teixeira de Moraes Gomes, Juliana Maria da Conceição, Fábio André Brayner, Luiz Carlos Alves, Ana Cristina Lima Leite
Phthalimide, 1,3-thiazole, and thiazolidinone cores are considered privileged scaffolds and represent an attractive starting point to design new bioactive compounds for neglected tropical disease (NTD). Schistosomiasis is a NTD, caused by Schistosoma worms which praziquantel (PZQ) is the only drug used to treat humans, but the decrease in the effect after treatment has been reported. Recently, some phthalimide-thiazole derivatives exhibited in vitro antischistosomal activity against adult worms with significant ultrastructural changes and a lower cytotoxic effect on splenocytes...
May 7, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29729414/semi-mechanistic-pharmacokinetic-pharmacodynamic-model-of-three-pegylated-rhuepo-and-ior%C3%A2-epocim-in-new-zealand-rabbits
#6
G Reynaldo-Fernández, J Solozábal, D Amaro, E M Fernández-Sánchez, L Rodríguez-Vera, M Bermejo, V Mangas-Sanjuan, I F Troconiz
Marketed formulations of erythropoietin (EPO) ior®EPOCIM, MIRCERA® and two newly developed pegylated-EPO analogues (PEG-EPO 32 and 40 kDa) formulations were intravenously administered to New Zealand rabbits. A semi-mechanistic Pharmacokinetic/Pharmacodynamic (PK/PD) model describing in a simultaneous and integrated form the time course of reticulocytes, red blood cells and hemoglobin was built to account for the time course of hematopoiesis stimulation after erythropoietin administration. Data analysis was performed based on the population approach with the software NONMEM version 7...
May 2, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29726309/distribution-of-porphyromonas-gingivalis-fima-genotypes-in-patients-affected-by-rheumatoid-arthritis-and-periodontitis
#7
José Luis Ayala-Herrera, Carlos Abud-Mendoza, Roberto F Gonzalez-Amaro, Leon Francisco Espinosa-Cristobal, Rita Elizabeth Martínez-Martínez
OBJECTIVE: To determine and compare the distribution of Porphyromonas gingivalis fimA genotypes in patients affected by Rheumatoid arthritis (RA) and periodontitis (PE). MATERIALS AND METHODS: This study involved 394 subjects divided into four groups, RA, PE, RA and PE and healthy subjects. PE was diagnosed by using clinical attachment loss (CAL) and probing depth (PD) indexes. Presence of P. gingivalis and its genotypes was identified by polymerase chain reaction in subgingival biofilm...
May 4, 2018: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/29725543/dietary-pattern-and-macronutrients-profile-on-the-variation-of-inflammatory-biomarkers-scientific-update
#8
REVIEW
Brenda Kelly Souza Silveira, Thatianne Moreira Silva Oliveira, Patrícia Amaro Andrade, Helen Hermana Miranda Hermsdorff, Carla de Oliveira Barbosa Rosa, Sylvia do Carmo Castro Franceschini
It is known that the dietary pattern and macronutrients profile may influence the expression and secretion of inflammatory biomarkers, and the low-grade inflammation is associated with the manifestation of noncommunicable chronic diseases. Therefore, this review aimed to present and discuss the role of dietary patterns and macronutrients on the variation of inflammatory markers related to NCD risk. Scientific evidences within the last five years based on clinical trials, case-controls, cohorts, and cross-sectional studies indicate that normocaloric, carbohydrate-moderated, low-glycemic index, protein-moderated, monounsaturated and polyunsaturated fatty acid-rich, omega-3, and low-saturated fat diets display positive effects on the inflammatory state, both in healthy individuals and in those with cardiovascular risk, although the second group seems to benefit more from changes in the dietary profile...
2018: Cardiology Research and Practice
https://www.readbyqxmd.com/read/29722054/pathoarchitectonics-of-the-cerebral-cortex-in-chorea-acanthocytosis-and-hd
#9
Jia Liu, Helmut Heinsen, Lea T Grinberg, Eduardo Alho, Edson Amaro, Carlos A Pasqualucci, Udo Rüb, Kay Seidel, Wilfred den Dunnen, Thomas Arzberger, Christoph Schmitz, Maren C Kiessling, Benedikt Bader, Adrian Danek
AIMS: Quantitative estimation of cortical neurone loss in cases with chorea-acanthocytosis and its impact on laminar composition METHODS: We used unbiased stereological tools to estimate the degree of cortical pathology in serial gallocyanin-stained brain sections through the complete hemispheres of three subjects with genetically verified chorea-acanthocytosis (ChAc) and a range of disease durations. We compared these results with our previous data of five Huntington's disease (HD) and five control cases...
May 2, 2018: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/29718927/predictive-saccades-in-children-and-adults-a-combined-fmri-and-eye-tracking-study
#10
Katerina Lukasova, Mariana P Nucci, Raymundo Machado de Azevedo Neto, Gilson Vieira, João R Sato, Edson Amaro
Saccades were assessed in 21 adults (age 24 years, SD = 4) and 15 children (age 11 years, SD = 1), using combined functional magnetic resonance imaging (fMRI) and eye-tracking. Subjects visually tracked a point on a horizontal line in four conditions: time and position predictable task (PRED), position predictable (pPRED), time predictable (tPRED) and visually guided saccades (SAC). Both groups in the PRED but not in pPRED, tPRED and SAC produced predictive saccades with latency below 80 ms. In task versus group comparisons, children's showed less efficient learning compared to adults for predictive saccades (adults = 48%, children = 34%, p = 0...
2018: PloS One
https://www.readbyqxmd.com/read/29713087/molecular-subtypes-of-diffuse-large-b-cell-lymphoma-are-associated-with-distinct-pathogenic-mechanisms-and-outcomes
#11
Bjoern Chapuy, Chip Stewart, Andrew J Dunford, Jaegil Kim, Atanas Kamburov, Robert A Redd, Mike S Lawrence, Margaretha G M Roemer, Amy J Li, Marita Ziepert, Annette M Staiger, Jeremiah A Wala, Matthew D Ducar, Ignaty Leshchiner, Ester Rheinbay, Amaro Taylor-Weiner, Caroline A Coughlin, Julian M Hess, Chandra S Pedamallu, Dimitri Livitz, Daniel Rosebrock, Mara Rosenberg, Adam A Tracy, Heike Horn, Paul van Hummelen, Andrew L Feldman, Brian K Link, Anne J Novak, James R Cerhan, Thomas M Habermann, Reiner Siebert, Andreas Rosenwald, Aaron R Thorner, Matthew L Meyerson, Todd R Golub, Rameen Beroukhim, Gerald G Wulf, German Ott, Scott J Rodig, Stefano Monti, Donna S Neuberg, Markus Loeffler, Michael Pfreundschuh, Lorenz Trümper, Gad Getz, Margaret A Shipp
Diffuse large B cell lymphoma (DLBCL), the most common lymphoid malignancy in adults, is a clinically and genetically heterogeneous disease that is further classified into transcriptionally defined activated B cell (ABC) and germinal center B cell (GCB) subtypes. We carried out a comprehensive genetic analysis of 304 primary DLBCLs and identified low-frequency alterations, captured recurrent mutations, somatic copy number alterations, and structural variants, and defined coordinate signatures in patients with available outcome data...
April 30, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29708732/protein-co-factors-are-essential-for-high-affinity-dna-binding-by-the-nuclear-factor-%C3%AE%C2%BAb-rela-subunit
#12
Maria Carmen Mulero, Shandy Shahabi, Myung Soo Ko, Jamie M Schiffer, Debin Huang, Vivien Ya-Fan Wang, Rommie E Amaro, Tom Huxford, Gourisankar Ghosh
Transcription activator proteins typically contain two functional domains: a DNA binding domain (DBD) that binds to DNA with sequence specificity, and an activation domain (AD) whose established function is to recruit RNA polymerase. In this report, we show that purified recombinant nuclear factor κB (NF-κB) RelA dimers bind specific κB DNA sites with significantly lower affinity than the same dimers from nuclear extracts of activated cells suggesting that additional nuclear co-factors might facilitate DNA binding by the RelA dimers...
April 30, 2018: Biochemistry
https://www.readbyqxmd.com/read/29704068/led-phototherapy-in-full-thickness-burns-induced-by-co-2-laser-in-rats-skin
#13
Milene da Silva Melo, Leandro Procópio Alves, Adriana Barrinha Fernandes, Henrique Cunha Carvalho, Carlos José de Lima, Egberto Munin, Mônica Fernandes Gomes, Miguel Angel Castillo Salgado, Renato Amaro Zângaro
Many studies have been conducted on the treatment of burns because they are important in morbidity and mortality. These studies are mainly focused on improving care and quality of life of patients. The aim of this study was evaluate the LED phototherapy effects in rats skin full-thickness burns induced by CO2 laser. The animals were divided in NT group that did not received any treatment and LED group that received LED irradiation at 685 nm, 220 mW, and 4.5 J/cm2 during 40 s by burned area. Biopsies were obtained after 7, 14, and 21 days of treatment and submitted to histological and immunohistochemical analysis...
April 27, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29697309/comprehensive-identification-of-vibrio-vulnificus-genes-required-for-growth-in-human-serum
#14
M Carda-Diéguez, F X Silva-Hernández, T P Hubbard, M C Chao, M K Waldor, C Amaro
Vibrio vulnificus can be a highly invasive pathogen capable of spreading from an infection site to the bloodstream, causing sepsis and death. To survive and proliferate in blood, the pathogen requires mechanisms to overcome the innate immune defenses and metabolic limitations of this host niche. We created a high-density transposon mutant library in YJ016, a strain representative of the most virulent V. vulnificus lineage (or phylogroup) and used transposon insertion sequencing (TIS) screens to identify loci that enable the pathogen to survive and proliferate in human serum...
April 26, 2018: Virulence
https://www.readbyqxmd.com/read/29690927/effects-of-transcranial-led-therapy-on-the-cognitive-rehabilitation-for-diffuse-axonal-injury-due-to-severe-acute-traumatic-brain-injury-study-protocol-for-a-randomized-controlled-trial
#15
João Gustavo Rocha Peixoto Dos Santos, Ana Luiza Costa Zaninotto, Renato Amaro Zângaro, Ana Maria Costa Carneiro, Iuri Santana Neville, Almir Ferreira de Andrade, Manoel Jacobsen Teixeira, Wellingson Silva Paiva
BACKGROUND: Photobiomodulation describes the use of red or near-infrared light to stimulate or regenerate tissue. It was discovered that near-infrared wavelengths (800-900 nm) and red (600 nm) light-emitting diodes (LED) are able to penetrate through the scalp and skull and have the potential to improve the subnormal cellular activity of compromised brain tissue. Different experimental and clinical studies were performed to test LED therapy for traumatic brain injury (TBI) with promising results...
April 24, 2018: Trials
https://www.readbyqxmd.com/read/29689622/prognostic-value-of-chromosomal-imbalances-gene-mutations-and-bap1-expression-in-uveal-melanoma
#16
Serena Patrone, Irena Maric, Mariangela Rutigliani, Francesco Lanza, Matteo Puntoni, Barbara Banelli, Silvia Rancati, Giovanna Angelini, Adriana Amaro, Paolo Ligorio, Carlotta Defferrari, Mauro Castagnetta, Roberto Bandelloni, Carlo Mosci, Andrea DeCensi, Massimo Romani, Urlich Pfeffer, Silvia Viaggi, Domenico A Coviello
Uveal melanoma (UM) exhibits recurring chromosomal abnormalities and gene driver mutations, which are related to tumor evolution/progression. Almost half of the patients with UM develop distant metastases, predominantly to the liver, and so far there are no effective adjuvant therapies. An accurate UM genetic profile could assess the individual patient's metastatic risk, and provide the basis to determine an individualized targeted therapeutic strategy for each UM patient. To investigate the presence of specific chromosomal and gene alterations, BAP1 protein expression, and their relationship with distant progression free survival (DPFS), we analyzed tumor samples from 63 UM patients (40 men and 23 women, with a median age of 64 years), who underwent eye enucleation by a single cancer ophthalmologist from December 2005 to June 2016...
April 24, 2018: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/29667206/surveillance-of-donated-blood-during-the-2016-arbovirus-outbreak-in-brazil
#17
Rohit Sharma, Larissa Costa Santos, Robson Amaro da Silva, Caroline Vieira Gonçalves, Stéfano de Melo Calado, Denisar P Santos, Josana Passos de Andrade de Melo, Rita de Cássia Pontello Rampazzo, Luciana Requião, Marco Aurélio Krieger, Manoel Barral-Netto, Camila I de Oliveira
Reports of arboviral transmission via blood transfusion may be a cause of concern among asymptomatic infected donors. This study evaluated the presence of arboviruses in donated blood products during the 2016 outbreak in Vitória da Conquista (Bahia-Brazil). Serum samples (n = 676) were screened for ZIKV, CHIKV and the four DENV serotypes using a one-step reverse transcriptase-based Real-Time Polymerase Chain Reaction (RT-PCR). No samples tested positive for any of the targets, whereas positive controls performed as expected...
April 17, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29659331/comparative-analysis-of-aging-policy-reforms-in-argentina-chile-costa-rica-and-mexico
#18
Esteban Calvo, Maureen Berho, Mónica Roqué, Juan Sebastián Amaro, Fernando Morales, Emiliana Rivera, Luis Miguel F Gutiérrez Robledo, Elizabeth Caro López, Bernardita Canals, Rosa Kornfeld
This investigation uses case studies and comparative analysis to review and analyze aging policy in Argentina, Chile, Costa Rica, and Mexico, and uncovers similarities and relevant trends in the substance of historical and current aging policy across countries. Initial charity-based approaches to poverty and illness have been gradually replaced by a rights-based approach considering broader notions of well-being, and recent reforms emphasize the need for national, intersectoral, evidence-based policy. The results of this study have implications for understanding aging policy in Latin America from a welfare regime and policymakers' perspective, identifying priorities for intervention, and informing policy reforms in developing countries worldwide...
April 16, 2018: Journal of Aging & Social Policy
https://www.readbyqxmd.com/read/29655339/aqueous-solvation-of-mg-ii-and-ca-ii-a-born-oppenheimer-molecular-dynamics-study-of-microhydrated-gas-phase-clusters
#19
C I León-Pimentel, J I Amaro-Estrada, J Hernández-Cobos, H Saint-Martin, A Ramírez-Solís
The hydration features of [Mg(H2 O)n ]2+ and [Ca(H2 O)n ]2+ clusters with n = 3-6, 8, 18, and 27 were studied by means of Born-Oppenheimer molecular dynamics simulations at the B3LYP/6-31+G** level of theory. For both ions, it is energetically more favorable to have all water molecules in the first hydration shell when n ≤ 6, but stable lower coordination average structures with one water molecule not directly interacting with the ion were found for Mg2+ at room temperature, showing signatures of proton transfer events for the smaller cation but not for the larger one...
April 14, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29649654/hpv-dna-methylation-at-the-early-promoter-and-e1-e2-integrity-a-comparison-between-hpv16-hpv18-and-hpv45-in-cervical-cancer
#20
Sérgio Menezes Amaro-Filho, Cláudia Bessa Pereira Chaves, Shayany Pinto Felix, Diogo Lisbôa Basto, Liz Maria de Almeida, Miguel Angelo Martins Moreira
OBJECTIVES: To compare and describe type-specific characteristics of HPV16, HPV18 and HPV45 in cervical cancer with respect to 3'LCR methylation and disruption of E1/E2. METHODS: The methylation level of 137 cervical cancer samples (70 with HPV16, 37 with HPV18, and 30 with HPV45) of Brazilian patients was analyzed by pyrosequencing. PCR amplifications were performed to characterize E1 and E2 disruption as an episomal surrogate. RESULTS: The 3'LCR of HPV16 showed a higher methylation at all CpG sites (7%, 9%, 11%, 10% and 10%) than homologous HPV18 regions (4%, 5%...
April 9, 2018: Papillomavirus Research
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