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https://www.readbyqxmd.com/read/28742702/trends-on-axillary-surgery-in-nondistant-metastatic-breast-cancer-patients-treated-between-2011-and-2015-a-dutch-population-based-study-in-the-acosog-z0011-and-amaros-era
#1
Ingrid G M Poodt, Pauline E R Spronk, Guusje Vugts, Thijs van Dalen, M T F D Vrancken Peeters, Marjolijn L Rots, Anne Kuijer, Grard A P Nieuwenhuijzen, Robert-Jan Schipper
OBJECTIVES: To evaluate patterns of care in axillary surgery for Dutch clinical T1-4N0M0 (cT1-4N0M0) breast cancer patients and to assess the effect of the American College for Surgeons Oncology Group (ACOSOG)-Z0011 and After Mapping of the Axilla: Radiotherapy Or Surgery (AMAROS) trial on axillary surgery patterns in Dutch cT1-2N0M0 sentinel node positive breast cancer patients. BACKGROUND: Since publication of the ACOSOG-Z0011 and AMAROS trial, omitting a completion axillary lymph node dissection (cALND) in sentinel node positive breast cancer patients is proposed in selected patients...
July 24, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28727389/schooling-impacts-on-the-overactive-bladder-diagnosis-in-women
#2
Larissa R Ferreira, Monica O Gameiro, Paulo R Kawano, Hamilto A Yamamoto, Rodrigo Guerra, Leonardo O Reis, João L Amaro
OBJECTIVE: To evaluate the overactive bladder (OAB) diagnosis using OAB-V8 and ICIQ-OAB questionnaires in women with different schooling and cultural levels. MATERIALS AND METHODS: Three hundred and eighty six healthy women answered a clinical questionnaire filling out information about schooling, demographic and gynecological data. The OAB-V8 and ICIQ-OAB questionnaires were used to evaluate OAB diagnosis and symptoms; and the QS-F questionnaire, to determine the sexual function...
July 20, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28711765/functional-magnetic-resonance-imaging-response-as-an-early-biomarker-of-cognitive-decline-in-elderly-patients-with-metabolic-syndrome
#3
Nadia Shigaeff, Edson Amaro, Fabio G M Franco, Alessandro F Jacinto, Gabriela Chiochetta, Maysa S Cendoroglo, Vanessa A Citero
OBJECTIVES: We assessed whether potential changes in brain activation patterns of elderly individuals with metabolic syndrome (MetS) who were cognitively healthy (without mild cognitive impairment or dementia) were associated with cognitive decline in executive function in the short-term. METHOD: We analyzed 43 individuals (23 MetS, 20 controls) using a global geriatric evaluation, a neuropsychological battery, and task-related (attention) fMRI exam. Correlation analysis between the fMRI signal at baseline and cognitive impairment after 1year was based on the voxel-based Pearson coefficient, corrected for multiple comparisons...
July 8, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28711253/the-capacity-of-silage-inoculant-bacteria-to-bind-aflatoxin-b1-in-vitro-and-in-artificially-contaminated-corn-silage
#4
Z X Ma, F X Amaro, J J Romero, O G Pereira, K C Jeong, A T Adesogan
The objectives were to examine the aflatoxin B1 (AFB1)-binding capacity of silage bacteria and factors affecting the responses. Experiments 1 and 2 examined the effects of bacterial strain and population on the AFB1-binding capacity of 10 bacteria. When applied at 10(6) cfu/mL to an in vitro medium, only Lactobacillus plantarum PT5B bound the AFB1 and the binding capacity was low (4%). When applied at 10(9) cfu/mL, all 10 bacteria bound AFB1, but L. plantarum R2014 (Lp) and EQ12, Lactobacillus buchneri R1102 (Lb), and Pediococcus acidilactici R2142 and EQ01 (Pa) had the greatest capacity (23...
July 12, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28710349/lipid-driven-nanodomains-in-giant-lipid-vesicles-are-fluid-and-disordered
#5
Alena Koukalová, Mariana Amaro, Gokcan Aydogan, Gerhard Gröbner, Philip T F Williamson, Ilya Mikhalyov, Martin Hof, Radek Šachl
It is a fundamental question in cell biology and biophysics whether sphingomyelin (SM)- and cholesterol (Chol)- driven nanodomains exist in living cells and in model membranes. Biophysical studies on model membranes revealed SM and Chol driven micrometer-sized liquid-ordered domains. Although the existence of such microdomains has not been proven for the plasma membrane, such lipid mixtures have been often used as a model system for 'rafts'. On the other hand, recent super resolution and single molecule results indicate that the plasma membrane might organize into nanocompartments...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28680488/sudden-sensorioneural-hearing-loss-and-autoimmune-systemic-diseases
#6
Bruno Almeida Antunes Rossini, Norma de Oliveira Penido, Mario Sergio Lei Munhoz, Eduardo Amaro Bogaz, Renata Souza Curi
Introduction  Several authors have demonstrated the relationship between sudden sensorineural hearing loss (SNHL) and systemic autoimmune diseases (SAD). Immune-mediated SNHL can rarely present as unilateral sudden SNHL and manifests itself in the contralateral ear only after years. It presents clinical relevance for being one of the few SNHL that may be reversible given that early and appropriate treatment is applied. Objective  The objective of this study is to describe the clinical presentations and audiological findings from patients with idiopathic sudden SNHL and SAD associated with a probable diagnosis of immune-mediated SNHL...
July 2017: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/28676757/greater-cortical-thickness-in-elderly-female-yoga-practitioners-a-cross-sectional-study
#7
Rui F Afonso, Joana B Balardin, Sara Lazar, João R Sato, Nadja Igarashi, Danilo F Santaella, Shirley S Lacerda, Edson Amaro, Elisa H Kozasa
Yoga, a mind-body activity that requires attentional engagement, has been associated with positive changes in brain structure and function, especially in areas related to awareness, attention, executive functions and memory. Normal aging, on the other hand, has also been associated with structural and functional brain changes, but these generally involve decreased cognitive functions. The aim of this cross-sectional study was to compare brain cortical thickness (CT) in elderly yoga practitioners and a group of age-matched healthy non-practitioners...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28676085/nasal-administration-of-the-neuroprotective-candidate-neuroepo-to-healthy-volunteers-a-randomized-parallel-open-label-safety-study
#8
Orestes Santos-Morales, Alina Díaz-Machado, Daise Jiménez-Rodríguez, Yaisel Pomares-Iturralde, Tatiana Festary-Casanovas, Carlos A González-Delgado, Sonia Pérez-Rodríguez, Eulalia Alfonso-Muñoz, Carmen Viada-González, Patricia Piedra-Sierra, Idrian García-García, Daniel Amaro-González, Julio César García-Rodríguez, Iliana Sosa-Testé, Alicia Lagarto-Parra, Laura Barrero-Viera, Marlene David-Baldo, Maura Tamayo-Rodríguez, Ivonne Rivero-Vázquez, Gricel González-Gamiz, Alis Martín-Trujillo, Yasmila Rodríguez-Fernández, Ana Alfa Ledo-de la Luz, Maylén Álvarez-Delgado, Ivón Howland-Álvarez, Yolanda Cruz-Gómez
BACKGROUND: Delivery of therapeutic agents as erythropoietin (EPO) into Central Nervous System through intranasal route could benefit patients with neurological disorders. A new nasal formulation containing a non-hematopoietic recombinant EPO (NeuroEPO) has shown neuroprotective actions in preclinical models. In the current study, the safety of NeuroEPO was evaluated for the first time in humans. METHODS: A phase I, randomized, parallel, open-label study was carried out in healthy volunteers...
July 4, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28675866/assessing-human-health-risks-and-strategies-for-phytoremediation-in-soils-contaminated-with-as-cd-pb-and-zn-by-slag-disposal
#9
William Ramos da Silva, Fernando Bruno Vieira da Silva, Paula Renata Muniz Araújo, Clístenes Williams Araújo do Nascimento
Soils impacted by metallurgy activities pose serious risks to the health of exposed populations, whether by ingestion of soil or contaminated food and water. The municipality of Santo Amaro, Bahia state, presents the most important case of human lead contamination in Brazil. It occurred because of inadequate slag disposal. The aims of this research were to: (i) determine the environmentally available concentrations and the distribution of As, Cd, Pb, and Zn in soil fractions; (ii) estimate the non-carcinogenic and carcinogenic risks of these elements for children; and (iii) to evaluate the use of corn (Zea mays) and castor bean (Ricinus communis) either for phytoextraction induced by chelating agents or phytostabilization...
July 1, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28675043/effect-of-round-curvature-of-anterior-implant-supported-zirconia-frameworks-finite-element-analysis-and-in-vitro-study-using-digital-image-correlation
#10
Ana Messias, Maria Augusta Neto, Ana Martins Amaro, Pedro Nicolau, Luis Manuel Roseiro
Two groups of 4-unit zirconia frameworks were produced by CAD/CAM to simulate the restoration of an anterior edentulous gap supported by 2 implant-abutment assemblies. Group 1 comprised straight configuration frameworks and group 2 consisted of arched frameworks. Specimens were made with the same connector cross-section area and were cemented and submitted to static loads. Displacements were captured with two high-speed photographic cameras and analysed with video correlation system. Frameworks and the implant-abutment assembly were scanned and converted to 3DCAD objects by reverse engineering process...
July 4, 2017: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/28674791/effects-of-the-gaalas-diode-laser-780%C3%A2-nm-on-the-periodontal-tissues-during-orthodontic-tooth-movement-in-diabetes-rats-histomorphological-and-immunohistochemical-analysis
#11
Mônica Fernandes Gomes, Maria da Graças Vilela Goulart, Lilian Chrystiane Giannasi, Cybelle Mori Hiraoka, Gabriela de Fátima Santana Melo, Aretha Graziela Vilela de Sousa, Celestino José Prudente Nóbrega, Renato Amaro Zangaro, Miguel Angel Castillo Salgado
The purposes of the present study are to assess the effects of the GaAlAs diode laser on the periodontal tissues and to investigate its action on the alveolar bone remodeling process during orthodontic tooth movement in normoglycemic and diabetic rats. Sixty adult male Wistar rats were divided into four groups of 15 rats: normoglycemic (N), diabetic (D), laser-normoglycemic (LN), and laser-diabetic (LD) rats. Diabetes mellitus was induced by a single intravenous injection of 40 mg/kg monohydrated alloxan. The orthodontically moved tooth underwent a force magnitude of 20 cN...
July 3, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28673811/fluid-attenuated-inversion-recovery-vascular-hyperintensities-in-patients-with-transient-ischemic-attack
#12
Marcelo Marinho de Figueiredo, Edson Amaro Júnior, Maramélia Araújo de Miranda Alves, Marcela Vazzoler, Renata Carolina Acre Nunes Miranda, Gisele Sampaio Silva
BACKGROUND: Fluid-attenuated inversion recovery (FLAIR) vascular hyperintensities (FVHs) are common in patients with acute ischemic stroke, possibly representing impaired hemodynamics in the ischemic territory due to intracranial steno-occlusive disease. There are few reports on FVHs in patients with transient ischemic attack (TIA). AIMS: We investigated the prevalence of FVHs and its clinical correlations in patients with TIA. METHODS: We evaluated consecutive patients admitted with TIA from February 2009 to June 2012 who had undergone magnetic resonance imaging within 30 hours of symptoms onset and intracranial and extracranial vascular imaging...
June 30, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28669056/pathogenic-th17-and-th22-cells-are-increased-in-patients-with-autoimmune-thyroid-disorders
#13
Marlen Vitales-Noyola, Ana M Ramos-Levi, Rebeca Martínez-Hernández, Ana Serrano-Somavilla, Miguel Sampedro-Nuñez, Roberto González-Amaro, Mónica Marazuela
PURPOSE: To study the levels of pathogenic and non-pathogenic Th17 and Th22 cells in autoimmune thyroid disorders patients. Although Th17 cells seem to play an important role in the pathogenesis of thyroid autoimmune disorders, the specific subsets of these lymphocytes have not been analyzed in this condition. METHODS: We assessed the levels of Th17 (pathogenic and non-pathogenic) and Th22 cells in peripheral blood and thyroid glands of autoimmune thyroid disorders patients (n   =  26, 16 with Graves' disease and 10 with Hashimoto's thyroiditis) and 15 healthy controls by multi-parametric flow cytometry and immunofluorescence microscopy...
July 1, 2017: Endocrine
https://www.readbyqxmd.com/read/28664899/corrigendum-recurrent-hormone-binding-domain-truncated-esr1-amplifications-in-primary-endometrial-cancers-suggest-their-implication-in-hormone-independent-growth
#14
Frederik Holst, Erling A Hoivik, William J Gibson, Amaro Taylor-Weiner, Steven E Schumacher, Yan W Asmann, Patrick Grossmann, Jone Trovik, Brian M Necela, E Aubrey Thompson, Matthew Meyerson, Rameen Beroukhim, Helga B Salvesen, Andrew D Cherniack
This corrects the article DOI: 10.1038/srep25521.
June 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28661131/molecular-simulations-reveal-an-unresolved-conformation-of-the-type-ia-protein-kinase-a-regulatory-subunit-and-suggest-its-role-in-the-camp-regulatory-mechanism
#15
Sophia P Hirakis, Robert D Malmstrom, Rommie E Amaro
We identify a previously unresolved, unrecognized, and highly stable conformation of the protein kinase A (PKA) regulatory subunit RIα. This conformation, which we term the "Flipback" structure, bridges conflicting characteristics in crystallographic structures and solution experiments of the PKA RIα heterotetramer. Our simulations reveal a hinge residue, G235, in the B/C helix that is conserved through all isoforms of RI. Brownian dynamics simulations suggest that the Flipback conformation plays a role in cAMP association to the A domain of the R subunit...
July 17, 2017: Biochemistry
https://www.readbyqxmd.com/read/28658208/recurrent-and-functional-regulatory-mutations-in-breast-cancer
#16
Esther Rheinbay, Prasanna Parasuraman, Jonna Grimsby, Grace Tiao, Jesse M Engreitz, Jaegil Kim, Michael S Lawrence, Amaro Taylor-Weiner, Sergio Rodriguez-Cuevas, Mara Rosenberg, Julian Hess, Chip Stewart, Yosef E Maruvka, Petar Stojanov, Maria L Cortes, Sara Seepo, Carrie Cibulskis, Adam Tracy, Trevor J Pugh, Jesse Lee, Zongli Zheng, Leif W Ellisen, A John Iafrate, Jesse S Boehm, Stacey B Gabriel, Matthew Meyerson, Todd R Golub, Jose Baselga, Alfredo Hidalgo-Miranda, Toshi Shioda, Andre Bernards, Eric S Lander, Gad Getz
Genomic analysis of tumours has led to the identification of hundreds of cancer genes on the basis of the presence of mutations in protein-coding regions. By contrast, much less is known about cancer-causing mutations in non-coding regions. Here we perform deep sequencing in 360 primary breast cancers and develop computational methods to identify significantly mutated promoters. Clear signals are found in the promoters of three genes. FOXA1, a known driver of hormone-receptor positive breast cancer, harbours a mutational hotspot in its promoter leading to overexpression through increased E2F binding...
July 6, 2017: Nature
https://www.readbyqxmd.com/read/28646389/photodynamic-therapy-controls-of-staphylococcus-aureus-intradermal-infection-in-mice
#17
Palloma Porto Almeida, Ítalo Sousa Pereira, Karine Bitencourt Rodrigues, Lorena Santos Leal, Andressa Souza Marques, Luciano Pereira Rosa, Francine Cristina da Silva, Robson Amaro Augusto da Silva
Infections caused by Staphylococcus aureus lead to skin infections, as well as soft tissues and bone infections. Given the communal resistance to antibiotics developed by strains of this bacterium, photodynamic therapy emerges as a promising alternative treatment to control and cure infections. Females of the Balb/C mice were infected with 10(8) CFU of methicillin-resistant S. aureus (MRSA) and divided into four distinct groups: P-L- (negative control group), P+L- (group exposed only to curcumin), P-L+ (group exposed only to LED incidence of 450 nm, 75 mW/cm(2), and 54 J/cm(2) for 10 min), and P+L+ (group exposed to curcumin followed by 10 min of LED irradiation) (n = 24)...
June 23, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28645848/fe-and-experimental-study-on-how-the-cortex-material-properties-of-synthetic-femurs-affect-strain-levels
#18
Vitor M M Lopes, Maria A Neto, Ana M Amaro, Luis M Roseiro, M F Paulino
The primary aim of this work was to validate the "numerical" cortex material properties (transversely isotropic) of synthetic femurs and to evaluate how the strain level of the cancellous bone can be affected by the FE modeling of the material's behavior. Sensitivity analysis was performed to find out if the parameters of the cortex material affect global strain results more than the Polyurethane (PU) foam used to simulate cancellous bone. Standard 4th generation composite femurs were made with 0.32g/cm(3) solid PU foam to model healthy cancellous bone, while 0...
June 20, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28636905/a-kepler-workflow-tool-for-reproducible-amber-gpu-molecular-dynamics
#19
Shweta Purawat, Pek U Ieong, Robert D Malmstrom, Garrett J Chan, Alan K Yeung, Ross C Walker, Ilkay Altintas, Rommie E Amaro
With the drive toward high throughput molecular dynamics (MD) simulations involving ever-greater numbers of simulation replicates run for longer, biologically relevant timescales (microseconds), the need for improved computational methods that facilitate fully automated MD workflows gains more importance. Here we report the development of an automated workflow tool to perform AMBER GPU MD simulations. Our workflow tool capitalizes on the capabilities of the Kepler platform to deliver a flexible, intuitive, and user-friendly environment and the AMBER GPU code for a robust and high-performance simulation engine...
June 20, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28635541/association-between-abnormal-brain-functional-connectivity-in-children-and-psychopathology-a-study-based-on-graph-theory-and-machine-learning
#20
João Ricardo Sato, Claudinei Eduardo Biazoli, Giovanni Abrahão Salum, Ary Gadelha, Nicolas Crossley, Gilson Vieira, André Zugman, Felipe Almeida Picon, Pedro Mario Pan, Marcelo Queiroz Hoexter, Edson Amaro, Mauricio Anés, Luciana Monteiro Moura, Marco Antonio Gomes Del'Aquilla, Philip Mcguire, Luis Augusto Rohde, Euripedes Constantino Miguel, Andrea Parolin Jackowski, Rodrigo Affonseca Bressan
OBJECTIVES: One of the major challenges facing psychiatry is how to incorporate biological measures in the classification of mental health disorders. Many of these disorders affect brain development and its connectivity. In this study, we propose a novel method for assessing brain networks based on the combination of a graph theory measure (eigenvector centrality) and a one-class support vector machine (OC-SVM). METHODS: We applied this approach to resting-state fMRI data from 622 children and adolescents...
February 8, 2017: World Journal of Biological Psychiatry
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