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https://www.readbyqxmd.com/read/28922960/cognitive-performance-in-transient-global-hypoxic-brain-injury-due-to-moderate-drowning
#1
Mariana Penteado Nucci, Katerina Lukasova, Gilson Vieira, João Ricardo Sato, Edson Amaro Júnior
INTRODUCTION: Drowning is a serious and frequently neglected public health threat. Primary respiratory impairment after submersion often leads to brain dysfunction. Depending on the period of global hypoxia (respiratory failure), clinical aspects of neurological dysfunction are evident on the first evaluation after the water rescue. Nowadays, many neuropsychological assessments after drowning are inconclusive, with some studies reporting only minor neurological or cognitive impairments...
September 19, 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/28918120/moment-by-moment-in-women-s-recovery-randomized-controlled-trial-protocol-to-test-the-efficacy-of-a-mindfulness-based-intervention-on-treatment-retention-and-relapse-prevention-among-women-in-residential-treatment-for-substance-use-disorder
#2
Hortensia Amaro, David S Black
Although therapeutic treatments exist for substance use disorder (SUD), about half of individuals who enter treatment leave early and relapse to substance use. Early dropout from residential treatment places individuals at risk of relapse, and women in SUD residential treatment represent a vulnerable population. Evidence gaps persist for the use of mindfulness-based interventions (MBIs) among racially and ethnically diverse women with SUDs, especially regarding the efficacy of MBIs adapted to prevent residential dropout and relapse...
September 14, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28913594/developmental-trajectory-of-the-prefrontal-cortex-a-systematic-review-of-diffusion-tensor-imaging-studies
#3
Sónia S Sousa, Edson Amaro, Alberto Crego, Óscar F Gonçalves, Adriana Sampaio
Fluctuations in gray and white matter volumes in addition to the fibers' reorganization and refinement of synaptic connectivity apparently happen in a particular temporo-spatial sequence during the dynamic and prolonged process of cerebral maturation. These developmental events are associated with regional modifications of brain tissues and neural circuits, contributing to networks' specialization and enhanced cognitive processing. According to several studies, improvements in cognitive processes are possibly myelin-dependent and associated to white matter maturation...
September 15, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28912596/complete-reperfusion-is-required-for-maximal-benefits-of-mechanical-thrombectomy-in-stroke-patients
#4
Ángel Chamorro, Jordi Blasco, Antonio López, Sergio Amaro, Luis San Román, Laura Llull, Arturo Renú, Salvatore Rudilosso, Carlos Laredo, Victor Obach, Xabier Urra, Anna M Planas, Enrique C Leira, Juan Macho
A mTICI 2b or a mTICI 3 score are currently considered success following mechanical thrombectomy (MT) in acute stroke but is undetermined whether the two scores translate equivalent outcomes. We present a single-center, retrospective cohort of patients with anterior circulation stroke treated with MT and achieving a final mTICI score 2b or 3. A multimodal CT at baseline and a multimodal MRI at 24 hours assessed the growth of the infarct, and the modified Rankin Scale (mRS) assessed functional outcome at 90 days...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28910999/infection-with-opisthorchis-felineus-induces-intraepithelial-neoplasia-of-the-biliary-tract-in-a-rodent-model
#5
Maria João Gouveia, Maria Y Pakharukova, Thewarach Laha, Banchob Sripa, Galina A Maksimova, Gabriel Rinaldi, Paul J Brindley, Viatcheslav A Mordvinov, Teresina Amaro, Lucio Lara Santos, José Manuel Correia da Costa, Nuno Vale
The liver fluke Opisthorchis felineus is a member of the triad of epidemiologically relevant species of the trematode family Opisthorchiidae, and the causative agent of opisthorchiasis felinea over an extensive range that spans regions of Eurasia. The International Agency for Research on Cancer classifies the infection with the liver flukes Opisthorchis viverrini and Clonorchis sinensis as group 1 agents and a major risk factor for cholangiocarcinoma. However, the carcinogenic potential of the infection with O...
September 1, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28900476/breast-cancer-in-angola-molecular-subtypes-a-first-glance
#6
Fernando Miguel, Lygia Vieira Lopes, Eduardo Ferreira, Emília Ribas, Alexis Fuentes Pelaez, Conceição Leal, Teresina Amaro, Paula Lopes, Cristina Mendes Santos, Carlos Lopes, Lúcio Lara Santos
PURPOSE: The aim of this study was to investigate the breast cancer (BC) molecular subtypes according to its surrogate immunohistochemistry (IHC) markers. We conducted a preliminary study, to correlate the clinical pathological profiles and molecular subtypes of breast cancer in Luanda, Angola. METHODS: From January 2011 to 30 December 2014, 140 consecutive cases of microscopically confirmed invasive breast carcinoma were classified regarding histology and IHC (ER, PR, HER2, and Ki-67)...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28898788/molecular-modelling-and-quantum-biochemistry-computations-of-a-naturally-occurring-bioremediation-enzyme-alkane-hydroxylase-from-pseudomonas-putida-p1
#7
B G de Sousa, J I N Oliveira, E L Albuquerque, U L Fulco, V E Amaro, C A G Blaha
Many species of bacteria involved in degradation of n-alkanes have an important constitutional metabolic enzyme, the alkane hydroxylase called AlkB, specialized in the conversion of hydrocarbons molecules that can be used as carbon and/or energy source. This enzyme plays an important role in the microbial degradation of oil, chlorinated hydrocarbons, fuel additives, and many other compounds. A number of these enzymes has been biochemically characterized in detail because the potential of alkane hydroxylases to catalyse high added-value reactions is widely recognized...
September 1, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28891715/-where-it-falls-apart-barriers-to-retention-in-hiv-care-in-latino-immigrants-and-migrants
#8
Julie H Levison, Laura M Bogart, Iman F Khan, Dianna Mejia, Hortensia Amaro, Margarita Alegría, Steven Safren
Latino immigrants in the United States are disproportionately affected by HIV. Barriers to consistent attendance (retention) in HIV primary care constrain opportunities for HIV treatment success, but have not been specifically assessed in this population. We conducted semistructured interviews with 37 HIV-infected Latinos (aged ≥18 years and born in Puerto Rico or a Latin American Spanish-speaking country) and 14 HIV providers in metropolitan Boston (total n = 51). The Andersen Model of Healthcare Utilization informed a semistructured interview guide, which bilingual research staff used to explore barriers to HIV care...
September 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28868485/drug-induced-acute-pancreatitis-and-pseudoaneurysms-an-ominous-combination
#9
Diogo Branquinho, Daniel Ramos-Andrade, Luís Elvas, Pedro Amaro, Manuela Ferreira, Carlos Sofia
Rupture of pseudoaneurysms is rare but can be life-threatening complications of acute or chronic pancreatitis, usually due to enzymatic digestion of vessel walls crossing peripancreatic fluid collections. We report the case of a 40 year-old female, with multisystemic lupus and anticoagulated for prior thrombotic events, admitted for probable cyclosporine-induced acute pancreatitis. Hemodynamic instability occurred due to abdominal hemorrhage from two pseudoaneurysms inside an acute peri-pancreatic collection...
November 2016: GE Port J Gastroenterol
https://www.readbyqxmd.com/read/28855313/complexity-of-complement-resistance-factors-expressed-by-acinetobacter-baumannii-needed-for-survival-in-human-serum
#10
Amaro F Sanchez-Larrayoz, Noha M Elhosseiny, Marc G Chevrette, Yang Fu, Peter Giunta, Raúl G Spallanzani, Keerthikka Ravi, Gerald B Pier, Stephen Lory, Tomás Maira-Litrán
Acinetobacter baumannii is a bacterial pathogen with increasing impact in healthcare settings, due in part to this organism's resistance to many antimicrobial agents, with pneumonia and bacteremia as the most common manifestations of disease. A significant proportion of clinically relevant A. baumannii strains are resistant to killing by normal human serum (NHS), an observation supported in this study by showing that 12 out of 15 genetically diverse strains of A. baumannii are resistant to NHS killing. To expand our understanding of the genetic basis of A...
August 30, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28832742/ultrasound-parameters-of-normal-lacrimal-sac-and-chronic-dacryocystitis
#11
Marco Antonio de Campos Machado, João Amaro Ferrari Silva, Eduardo Alonso Garcia, Norma Allemann
PURPOSE: To compared the ultrasound findings of the lacrimal sac between subjects with normal lacrimal systems those with chronic dacryocystitis. METHODS: A retrospective study of 10 subjects with a normal lacrimal system (Group 1) and 10 with chronic dacryocystitis (Group 2) diagnosed according to B-mode ultrasound with a 10-MHz transducer and the direct-contact technique (AVISO, Quantel Medical) for lacrimal sac assessment. We analyzed the dimensions, features, and content of the sacs...
June 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28825604/effects-of-dry-land-strength-and-conditioning-programs-in-age-group-swimmers
#12
Nuno M Amaro, Daniel A Marinho, Mário C Marques, Nuno P Batalha, Pedro G Morouço
Amaro, NM, Marinho, DA, Marques, MC, Batalha, N, and Morouço, PG. Effects of dry-land strength and conditioning programs in age group swimmers. J Strength Cond Res 31(9): 2447-2454, 2017-Even though dry-land S&C training is a common practice in the context of swimming, there are countless uncertainties over its effects in performance of age group swimmers. The objective was to investigate the effects of dry-land S&C programs in swimming performance of age group swimmers. A total of 21 male competitive swimmers (12...
September 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28800393/povme-3-0-software-for-mapping-binding-pocket-flexibility
#13
Jeffrey R Wagner, Jesper Sørensen, Nathan Hensley, Celia Wong, Clare Zhu, Taylor Perison, Rommie E Amaro
We present a substantial update to the open-source POVME binding pocket analysis software. New capabilities of POVME 3.0 include a flexible chemical coloring scheme for feature identification, postanalysis tools for comparing large ensembles of pockets (e.g., from molecular dynamics simulations), and the introduction of scripts and methods that facilitate binding pocket comparison and analysis. We envision the use of this software for visualization of binding pocket dynamics, selection of representative structures for ensemble docking, and incorporation of molecular dynamics results into ligand design efforts...
August 30, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28770704/undifferentiated-connective-tissue-disease-predictors-of-evolution-into-definite-disease
#14
María García-González, Beatriz Rodríguez-Lozano, Sagrario Bustabad, Ivan Ferraz-Amaro
OBJECTIVES: The natural evolution of undifferentiated connective tissue diseases (UCTD) has not yet been established. The aim of our study was to analyse the clinical outcomes of a cohort of UCTD patients followed in a routine outpatient setting and to establish which clinical, serological or capillaroscopy features are associated with an increased risk of evolution to definite connective tissue disease (CTD). METHODS: Data for this study were collected by a retrospective review of 758 patients referred to our hospital, between 1999 and 2008, with suspected CTD...
August 2, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28765071/ficz-generates-human-tdcs-that-induce-cd4-cd25-high-foxp3-treg-like-cell-differentiation
#15
Brenda B Jurado-Manzano, Daniel Zavala-Reyes, Edgar A Turrubiartes-Martínez, Diana P Portales-Pérez, Roberto González-Amaro, Esther Layseca-Espinosa
Dendritic cells (DCs) play a central role in the maintenance of immune homeostasis, their participation as professional antigen presenting cells is essential to the initiation of the adaptive immune response as well as to the induction of tolerance. The recently described role of the aryl hydrocarbon receptor (AhR) in the immune system, particularly in the modulation of the adaptive immune response has attracted the attention as a potential player in the induction of immune tolerance. However, the effects of AhR activation through endogenous ligands on human DCs have been poorly evaluated...
July 29, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28759766/metal-toxicity-assessment-by-sentinel-species-of-mangroves-in-situ-case-study-integrating-chemical-and-biomarkers-analyses
#16
Luis Felipe de Almeida Duarte, Caroline Araújo de Souza, Camilo Dias Seabra Pereira, Marcelo Antonio Amaro Pinheiro
Globally, there is a lack of knowledge about tropical ecotoxicology dealing with the potential impact of metal contamination in mangrove ecosystem. This habitat is considered a nursery for several animal species, among them the "uçá"-crab (Ucides cordatus), known as a key species due to its biological and economical importance. This study evaluated the association involving metal contamination (Cd, Cu, Pb, Cr, Mn and Hg) in water, sediment, red-mangrove vegetation (Rhizophora mangle) and tissues of uçá crab, together with its geno-cytotoxic responses, based on micronucleated hemocytes frequency and the retention time of neutral red in lysosomes...
July 28, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28742702/trends-on-axillary-surgery-in-nondistant-metastatic-breast-cancer-patients-treated-between-2011-and-2015-a-dutch-population-based-study-in-the-acosog-z0011-and-amaros-era
#17
Ingrid G M Poodt, Pauline E R Spronk, Guusje Vugts, Thijs van Dalen, M T F D Vrancken Peeters, Marjolijn L Rots, Anne Kuijer, Grard A P Nieuwenhuijzen, Robert-Jan Schipper
OBJECTIVES: To evaluate patterns of care in axillary surgery for Dutch clinical T1-4N0M0 (cT1-4N0M0) breast cancer patients and to assess the effect of the American College for Surgeons Oncology Group (ACOSOG)-Z0011 and After Mapping of the Axilla: Radiotherapy Or Surgery (AMAROS) trial on axillary surgery patterns in Dutch cT1-2N0M0 sentinel node positive breast cancer patients. BACKGROUND: Since publication of the ACOSOG-Z0011 and AMAROS trial, omitting a completion axillary lymph node dissection (cALND) in sentinel node positive breast cancer patients is proposed in selected patients...
July 24, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28727389/schooling-impacts-on-the-overactive-bladder-diagnosis-in-women
#18
Larissa R Ferreira, Monica O Gameiro, Paulo R Kawano, Hamilto A Yamamoto, Rodrigo Guerra, Leonardo O Reis, João L Amaro
OBJECTIVE: To evaluate the overactive bladder (OAB) diagnosis using OAB-V8 and ICIQ-OAB questionnaires in women with different schooling and cultural levels. MATERIALS AND METHODS: Three hundred and eighty six healthy women answered a clinical questionnaire filling out information about schooling, demographic and gynecological data. The OAB-V8 and ICIQ-OAB questionnaires were used to evaluate OAB diagnosis and symptoms; and the QS-F questionnaire, to determine the sexual function...
July 20, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28711765/functional-magnetic-resonance-imaging-response-as-an-early-biomarker-of-cognitive-decline-in-elderly-patients-with-metabolic-syndrome
#19
Nadia Shigaeff, Edson Amaro, Fabio G M Franco, Alessandro F Jacinto, Gabriela Chiochetta, Maysa S Cendoroglo, Vanessa A Citero
OBJECTIVES: We assessed whether potential changes in brain activation patterns of elderly individuals with metabolic syndrome (MetS) who were cognitively healthy (without mild cognitive impairment or dementia) were associated with cognitive decline in executive function in the short-term. METHOD: We analyzed 43 individuals (23 MetS, 20 controls) using a global geriatric evaluation, a neuropsychological battery, and task-related (attention) fMRI exam. Correlation analysis between the fMRI signal at baseline and cognitive impairment after 1year was based on the voxel-based Pearson coefficient, corrected for multiple comparisons...
July 8, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28711253/the-capacity-of-silage-inoculant-bacteria-to-bind-aflatoxin-b1-in-vitro-and-in-artificially-contaminated-corn-silage
#20
Z X Ma, F X Amaro, J J Romero, O G Pereira, K C Jeong, A T Adesogan
The objectives were to examine the aflatoxin B1 (AFB1)-binding capacity of silage bacteria and factors affecting the responses. Experiments 1 and 2 examined the effects of bacterial strain and population on the AFB1-binding capacity of 10 bacteria. When applied at 10(6) cfu/mL to an in vitro medium, only Lactobacillus plantarum PT5B bound the AFB1 and the binding capacity was low (4%). When applied at 10(9) cfu/mL, all 10 bacteria bound AFB1, but L. plantarum R2014 (Lp) and EQ12, Lactobacillus buchneri R1102 (Lb), and Pediococcus acidilactici R2142 and EQ01 (Pa) had the greatest capacity (23...
September 2017: Journal of Dairy Science
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