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https://www.readbyqxmd.com/read/27910811/ll-37-hnp-1-and-hbd2-3-modulate-the-secretion-of-cytokines-tnf-%C3%AE-il-6-ifn-%C3%AE-il-10-and-mmp1-in-human-primary-cell-cultures
#1
Carlos Erik Medina Santos, Carmen Nathaly López Hurtado, Bruno Rivas Santiago, Roberto Gonzalez-Amaro, Yolanda Guadalupe Cataño Cañizales, Margarita de la Luz Martínez Fierro, José Antonio Enciso-Moreno, Mariana Haydee García Hernández
The aim of this study was to evaluate the effects of the LL-37, HNP-1 and HBD2/3 peptides on cytokine and MMP production in human polymorphonuclear cells, mononuclear cells and chondrocytes. The levels of cytokines in supernatants from mononuclear and polymorphonuclear cell cultures were measured with a cytometric bead array by flow cytometry. Likewise, the levels of metalloproteinase/MMP-1, 3, and 13 were measured in supernatants from chondrocyte cultures using an ELISA. The expression of RANKL on lymphocytes was analyzed by flow cytometry...
September 1, 2016: European Cytokine Network
https://www.readbyqxmd.com/read/27905446/genomic-evolution-and-chemoresistance-in-germ-cell-tumours
#2
Amaro Taylor-Weiner, Travis Zack, Elizabeth O'Donnell, Jennifer L Guerriero, Brandon Bernard, Anita Reddy, G Celine Han, Saud AlDubayan, Ali Amin-Mansour, Steven E Schumacher, Kevin Litchfield, Clare Turnbull, Stacey Gabriel, Rameen Beroukhim, Gad Getz, Scott L Carter, Michelle S Hirsch, Anthony Letai, Christopher Sweeney, Eliezer M Van Allen
Germ-cell tumours (GCTs) are derived from germ cells and occur most frequently in the testes. GCTs are histologically heterogeneous and distinctly curable with chemotherapy. Gains of chromosome arm 12p and aneuploidy are nearly universal in GCTs, but specific somatic genomic features driving tumour initiation, chemosensitivity and progression are incompletely characterized. Here, using clinical whole-exome and transcriptome sequencing of precursor, primary (testicular and mediastinal) and chemoresistant metastatic human GCTs, we show that the primary somatic feature of GCTs is highly recurrent chromosome arm level amplifications and reciprocal deletions (reciprocal loss of heterozygosity), variations that are significantly enriched in GCTs compared to 19 other cancer types...
November 30, 2016: Nature
https://www.readbyqxmd.com/read/27886519/mind-wandering-and-the-attention-network-system
#3
Óscar F Gonçalves, Gabriel Rêgo, Patrícia Oliveira-Silva, Jorge Leite, Sandra Carvalho, Felipe Fregni, Edson Amaro, Paulo S Boggio
Attention and mind wandering are often seen as anticorrelated. However, both attention and mind wandering are multi-component processes, and their relationship may be more complex than previously thought. In this study, we tested the interference of different types of thoughts as measured by a Thought Identification Task - TIT (on task thoughts, task related interference thoughts, external distractions, stimulus independent and task unrelated thoughts) on different components of the attention network system - ANT (alerting, orienting, executive)...
November 22, 2016: Acta Psychologica
https://www.readbyqxmd.com/read/27871138/high-genetic-diversity-of-vibrio-cholerae-in-the-european-lake-neusiedler-see-is-associated-with-intensive-recombination-in-the-reed-habitat-and-the-long-distance-transfer-of-strains
#4
Carina Pretzer, Irina S Druzhinina, Carmen Amaro, Eva Benediktsdóttir, Ingela Hedenström, Dominique Hervio-Heath, Steliana Huhulescu, Franciska M Schets, Andreas H Farnleitner, Alexander K T Kirschner
Coastal marine Vibrio cholerae populations usually exhibit high genetic diversity. To assess the genetic diversity of abundant V. cholerae non-O1/non-O139 populations in the Central European lake Neusiedler See we performed a phylogenetic analysis based on recA, toxR, gyrB and pyrH loci sequenced for 472 strains. The strains were isolated from three ecologically different habitats in a lake that is a hot-spot of migrating birds and an important bathing water. We also analysed 76 environmental and human V. cholerae non-O1/non-O139 isolates from Austria and other European countries and added sequences of seven genome-sequenced strains...
November 21, 2016: Environmental Microbiology
https://www.readbyqxmd.com/read/27868026/preclinical-randomized-controlled-multicenter-trials-in-translational-stroke-research
#5
COMMENT
Sergio Amaro, Laura Llull
No abstract text is available yet for this article.
October 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27854550/expression-and-function-of-the-co-stimulatory-receptor-slamf1-is-altered-in-lymphocytes-from-patients-with-autoimmune-thyroiditis
#6
Marlen Vitales-Noyola, Ana M Ramos-Levi, Ana Serrano-Somavilla, Rebeca Hernández-Martínez, Miguel Sampedro-Nuñez, Carmelina Di Pasquale, Roberto González-Amaro, Mónica Marazuela
CONTEXT: SLAMF1 is a co-stimulatory receptor that is expressed by most immune cells. Its role in Autoimmune Thyroid Disease (AITD) is not well known. OBJECTIVE: To analyze the expression and function of the co-stimulatory receptor SLAMF1 in lymphocytes of patients with AITD. DESIGN: Cross-sectional, prospective, single-center. SETTING: Department of Endocrinology, Hospital Universitario Princesa. PATIENTS: 28 patients with AITD (17 with Graves' disease and 11 with Hashimoto's thyroiditis) and 21 controls...
November 17, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27843167/use-of-transgenic-aedes-aegypti-in-brazil-risk-perception-and-assessment
#7
Paulo Paes de Andrade, Francisco José Lima Aragão, Walter Colli, Odir Antônio Dellagostin, Flávio Finardi-Filho, Mario Hiroyuki Hirata, Amaro de Castro Lira-Neto, Marcia Almeida de Melo, Alexandre Lima Nepomuceno, Francisco Gorgônio da Nóbrega, Gutemberg Delfino de Sousa, Fernando Hercos Valicente, Maria Helena Bodanese Zanettini
The OX513A strain of Aedes aegypti, which was developed by the British company Oxitec, expresses a self-limiting transgene that prevents larvae from developing to adulthood. In April 2014, the Brazilian National Technical Commission on Biosafety completed a risk assessment of OX513A and concluded that the strain did not present new biological risks to humans or the environment and could be released in Brazil. At that point, Brazil became the first country to approve the unconstrained release of a genetically modified mosquito...
October 1, 2016: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/27832673/extramammary-paget-disease-of-the-vulva-case-report
#8
Bianca Ruschel Hillmann, Amanda Amaro Pereira, Luiz Fernando Sommacal
Extramammary Paget disease (EPD) is a rare malign neoplasm that may affect the vulva and has manifestations common to benign diseases such as itching, pain and eczema. This leads to delay in diagnosis and consequent worse prognosis. The definitive diagnosis is obtained by biopsy of the vulva, which shows Paget cells. The treatment of choice is wide excision with margins, which leads to sequelae, functional and aesthetic. Recurrence is common. This article reports the case of a 48-year-old female patient with history of vulvar itching for the past 2 years, who had been submitted to various treatments for benign pathologies...
October 2016: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/27818955/rupture-of-an-ascending-aortic-aneurysm-as-a-cause-of-sudden-death
#9
Cristielle Peres de Freitas, Carla Andrade Petrini, Ramon Souza Goes Araújo, Luiz Guilherme Cernaglia Aureliano Lima, Patrícia Picciarelli de Lima, Amaro Nunes Duarte-Neto
An 84-year-old female patient was brought to the emergency department in cardiac arrest. Cardiopulmonary resuscitation maneuvers were performed but were unsuccessful. The patient had a past medical history of systemic arterial hypertension with target-organ lesions, including stroke and myocardial infarction. The autopsy was carried out, and the most striking finding was cardiac tamponade due to the rupture of an ascending aortic aneurysm at the site of a complex atheromatous plaque. Rupture is the most serious complication of a thoracic aneurysm and must be considered in the differential diagnosis of sudden death...
July 2016: Autopsy & case reports
https://www.readbyqxmd.com/read/27816195/co2-leakage-from-carbon-dioxide-capture-and-storage-ccs-systems-affects-organic-matter-cycling-in-surface-marine-sediments
#10
Eugenio Rastelli, Cinzia Corinaldesi, Antonio Dell'Anno, Teresa Amaro, Silvestro Greco, Marco Lo Martire, Laura Carugati, Ana M Queirós, Stephen Widdicombe, Roberto Danovaro
Carbon dioxide capture and storage (CCS), involving the injection of CO2 into the sub-seabed, is being promoted worldwide as a feasible option for reducing the anthropogenic CO2 emissions into the atmosphere. However, the effects on the marine ecosystems of potential CO2 leakages originating from these storage sites have only recently received scientific attention, and little information is available on the possible impacts of the resulting CO2-enriched seawater plumes on the surrounding benthic ecosystem. In the present study, we conducted a 20-weeks mesocosm experiment exposing coastal sediments to CO2-enriched seawater (at 5000 or 20,000 ppm), to test the effects on the microbial enzymatic activities responsible for the decomposition and turnover of the sedimentary organic matter in surface sediments down to 15 cm depth...
December 2016: Marine Environmental Research
https://www.readbyqxmd.com/read/27814578/lipid-raft-er-signalosome-malfunctions-in-menopause-and-alzheimer-s-disease
#11
Ana Canerina-Amaro, Luis G Hernandez-Abad, Isidre Ferrer, David Quinto-Alemany, Fatima Mesa-Herrera, Carla Ferri, Ricardo A Puertas-Avendano, Mario Diaz, Raquel Marin
The increase in the incidence of Alzheimer's disease (AD) in old women may be attributable to estrogen deficiency, and estrogen replacement therapy may be useful in preventing or delaying the onset of this disease. In neuronal membranes, 17 beta-estradiol interacts with estrogen receptors (mERs) located in lipid raft signalosomes which trigger neuroprotective responses by anchoring to scaffolding caveolin-1 complexed with other proteins. We suggest that mER-signalosome malfunctions in AD and by menopause due to development of aberrations in these microstructures...
January 1, 2017: Frontiers in Bioscience (Scholar Edition)
https://www.readbyqxmd.com/read/27797976/genomic-heterogeneity-and-exceptional-response-to-dual-pathway-inhibition-in-anaplastic-thyroid-cancer
#12
William J Gibson, Daniel T Ruan, Vera A Paulson, Justine A Barletta, Glenn J Hanna, Stefan Kraft, Antonio Calles, Matthew A Nehs, Francis D Moore, Amaro Taylor-Weiner, Jeremiah A Wala, Travis I Zack, Thomas C Lee, Fiona M Fennessy, Erik K Alexander, Tom Tomas, Pasi A Janne, Levi A Garraway, Scott L Carter, Rameen Beroukhim, Jochen H Lorch, Eliezer Van Allen
PURPOSE: Cancers may resist single-agent targeted therapies when the flux of cellular growth signals is shifted from one pathway to another. Blockade of multiple pathways may be necessary for effective inhibition of tumor growth. We document a case in which a patient with anaplastic thyroid carcinoma (ATC) failed to respond to either mTOR or combined RAF/MEK inhibition, but experienced a dramatic response when both drug regimens were combined. EXPERIMENTAL DESIGN: Multi-region whole-exome sequencing of five diagnostic and four autopsy tumor biopsies was performed...
October 17, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27797588/association-between-the-foki-and-apai-polymorphisms-in-the-vitamin-d-receptor-gene-and-intervertebral-disc-degeneration-a-systematic-review-and-meta-analysis
#13
Noel Pabalan, Lani Tabangay, Hamdi Jarjanazi, Luiz Angelo Vieira, Aline Amaro Dos Santos, Caio Parente Barbosa, Luciano Miller Reis Rodrigues, Bianca Bianco
BACKGROUND: Evidence supporting an association of intervertebral disc degeneration (DD) with polymorphisms of the vitamin D receptor (VDR) gene has been controversial. We perform a meta-analysis of these studies to determine if there was substantial evidence to support such an association between the VDR polymorphisms and DD. METHODS: PubMed, Embase, and Science Direct databases were searched for studies that investigated associations of the FokI (rs2228570, rs10735810), and ApaI (rs7975253) polymorphisms of the VDR gene with DD...
October 31, 2016: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/27760351/capturing-invisible-motions-in-the-transition-from-ground-to-rare-excited-states-of-t4-lysozyme-l99a
#14
Jamie M Schiffer, Victoria A Feher, Robert D Malmstrom, Roxana Sida, Rommie E Amaro
Proteins commonly sample a number of conformational states to carry out their biological function, often requiring transitions from the ground state to higher-energy states. Characterizing the mechanisms that guide these transitions at the atomic level promises to impact our understanding of functional protein dynamics and energy landscapes. The leucine-99-to-alanine (L99A) mutant of T4 lysozyme is a model system that has an experimentally well characterized excited sparsely populated state as well as a ground state...
October 18, 2016: Biophysical Journal
https://www.readbyqxmd.com/read/27759906/quantitative-and-functional-analysis-of-cd69-t-regulatory-lymphocytes-in-patients-with-periodontal-disease
#15
Marlen Vitales-Noyola, Rita Martínez-Martínez, Juan P Loyola-Rodríguez, Lourdes Baranda, Perla Niño-Moreno, Roberto González-Amaro
BACKGROUND: Periodontal disease is chronic inflammatory process that affects the attachment structures of the teeth and constitutes a significant cause of tooth loss in adults. Although different bacteria play an important role in the triggering of this condition, the progression and severity of the disease are strongly affected by the host immune response, which is under the control of different immune regulatory mechanisms, including T regulatory (Treg) cells. The aim of this study was to assess the frequency and function of CD69(+) Treg lymphocytes in patients with chronic periodontal disease...
October 19, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27758945/uric-acid-therapy-prevents-early-ischemic-stroke-progression-a-tertiary-analysis-of-the-urico-ictus-trial-efficacy-study-of-combined-treatment-with-uric-acid-and-r-tpa-in-acute-ischemic-stroke
#16
Sergio Amaro, Carlos Laredo, Arturo Renú, Laura Llull, Salvatore Rudilosso, Víctor Obach, Xabier Urra, Anna M Planas, Ángel Chamorro
BACKGROUND AND PURPOSE: Identification of neuroprotective therapies in acute ischemic stroke is imperative. We report a predefined analysis of the URICO-ICTUS trial (Efficacy Study of Combined Treatment With Uric Acid and r-tPA in Acute Ischemic Stroke) assessing the efficacy of uric acid (UA) compared with placebo to prevent early ischemic worsening (EIW) and the relevance of collateral circulation. METHODS: URICO-ICTUS was a double-blind, placebo-controlled, phase 2b trial where a total of 411 patients treated with alteplase within 4...
November 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27744351/rna-editing-tutase-1-structural-foundation-of-substrate-recognition-complex-interactions-and-drug-targeting
#17
Lional Rajappa-Titu, Takuma Suematsu, Paola Munoz-Tello, Marius Long, Özlem Demir, Kevin J Cheng, Jason R Stagno, Hartmut Luecke, Rommie E Amaro, Inna Aphasizheva, Ruslan Aphasizhev, Stéphane Thore
Terminal uridyltransferases (TUTases) execute 3' RNA uridylation across protists, fungi, metazoan and plant species. Uridylation plays a particularly prominent role in RNA processing pathways of kinetoplastid protists typified by the causative agent of African sleeping sickness, Trypanosoma brucei In mitochondria of this pathogen, most mRNAs are internally modified by U-insertion/deletion editing while guide RNAs and rRNAs are U-tailed. The founding member of TUTase family, RNA editing TUTase 1 (RET1), functions as a subunit of the 3' processome in uridylation of gRNA precursors and mature guide RNAs...
October 15, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27742582/neuroanatomical-correlates-of-stroke-associated-infection-and-stroke-induced-immunodepression
#18
Xabier Urra, Carlos Laredo, Yashu Zhao, Sergio Amaro, Salvatore Rudilosso, Arturo Renú, Alberto Prats-Galino, Anna M Planas, Laura Oleaga, Ángel Chamorro
BACKGROUND: Infections represent the most frequent medical complications in stroke patients. Their main determinants are dysphagia and a transient state of immunodepression. We analyzed whether distinct anatomical brain regions were associated with the occurrence of stroke-associated infections or immunodepression. MATERIALS AND METHODS: In 106 patients with acute ischemic stroke, we evaluated the incidence of pneumonia, urinary tract infection, or other infections together with the characterization of biomarkers of immunodepression...
October 11, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27734336/ficolin-1-levels-in-patients-developing-vasospasm-and-cerebral-ischemia-after-spontaneous-subarachnoid-hemorrhage
#19
Laura Llull, Steffen Thiel, Sergio Amaro, Álvaro Cervera, Anna M Planas, Ángel Chamorro
Activation of the inflammatory generating complement system might play a pathogenic role in spontaneous subarachnoid hemorrhage (SAH). We studied whether plasma and cerebrospinal fluid (CSF) levels of complement proteins were associated with angiographic vasospasm and cerebral ischemic lesions after SAH. Ficolin-1 (M-ficolin), ficolin-3 (H-ficolin), mannose-binding lectin (MBL), MBL-associated serine protease 2 (MASP-2), MASP-3, and MAp44 were analyzed in plasma of 45 SAH patients at 24 h after bleeding. Additionally, ficolin-1 levels were measured in cerebrospinal fluid (CSF) samples obtained 24 h after bleeding in 19 patients with external ventricular drainage placement...
October 12, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27734303/brain-injury-after-moderate-drowning-subtle-alterations-detected-by-functional-magnetic-resonance-imaging
#20
Mariana P Nucci, Katerina Lukasova, João R Sato, Edson Amaro
To describe cerebral (structural and functional MRI) and neuropsychological long term changes in moderate drowning victim's compared to healthy volunteers in working memory and motor domains. We studied 15 adult drowning victim's in chronic stage (DV - out of 157 eligible cases of sea water rescues with moderate drowning classification) paired to 18 healthy controls (HC). All participants were investigated using intelligence, memory, and attention neuropsychological standard tests and underwent functional (motor and working memory tasks) and structural magnetic resonance imaging (MRI) in a 3 T system...
October 12, 2016: Brain Imaging and Behavior
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