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https://www.readbyqxmd.com/read/27933411/society-of-surgical-oncology-breast-disease-working-group-statement-on-prophylactic-risk-reducing-mastectomy
#1
Kelly K Hunt, David M Euhus, Judy C Boughey, Anees B Chagpar, Sheldon M Feldman, Nora M Hansen, Swati A Kulkarni, David R McCready, Eleftherios P Mamounas, Lee G Wilke, Kimberly J Van Zee, Monica Morrow
Over the past several years, there has been an increasing rate of bilateral prophylactic mastectomy (BPM) and contralateral prophylactic mastectomy (CPM) surgeries. Since publication of the 2007 SSO position statement on the use of risk-reducing mastectomy, there have been significant advances in the understanding of breast cancer biology and treatment. The purpose of this manuscript is to review the current literature as a resource to facilitate a shared and informed decision-making process regarding the use of risk-reducing mastectomy...
December 8, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27931006/brca-mutation-genetic-testing-implications-in-the-united-states
#2
REVIEW
Soley Bayraktar, Banu Arun
BRCA mutation carriers have a very high risk of breast and ovarian cancer by age 70, in the ranges 47%-66% and 40%-57%, respectively. Additionally, women with BRCA mutation-associated breast cancer also have an elevated risk of other or secondary malignancies. Fortunately, the breast and ovarian cancer outcome for BRCA1/2 mutation carriers is at least as good as for non-carriers with chemoprevention, prophylactic surgeries and appropriate use of therapies. Therefore, identification of those who might have a mutation is important so that genetic counseling, testing, screening and prevention strategies can be applied in a timely manner...
December 5, 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27923403/determinants-for-patient-satisfaction-regarding-aesthetic-outcome-and-skin-sensitivity-after-breast-conserving-surgery
#3
Cecilia Dahlbäck, Jonas Manjer, Martin Rehn, Anita Ringberg
BACKGROUND: With the development of new surgical techniques in breast cancer, such as oncoplastic breast surgery, increased knowledge of risk factors for poor satisfaction with conventional breast-conserving surgery (BCS) is needed in order to determine which patients to offer these techniques to. The aim of this study was to investigate patient satisfaction regarding aesthetic result and skin sensitivity in relation to patient, tumour, and treatment factors, in a consecutive sample of patients undergoing conventional BCS...
December 7, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27899083/tumor-characteristics-and-prognosis-in-familial-breast-cancer
#4
G Arpino, M Pensabene, C Condello, R Ruocco, I Cerillo, R Lauria, V Forestieri, M Giuliano, C De Angelis, M Montella, A Crispo, S De Placido
BACKGROUND: Approximately 5-10% of breast cancers are hereditary and their biology and prognosis appear to differ from those of sporadic breast cancers. In this study we compared the biological features and clinical characteristics of non metastatic breast cancer in patients with BRCA mutations versus patients with a family history suggesting hereditary breast cancer but without BRCA mutations (BRCA wild type) versus patients with sporadic disease, and correlated these findings with clinical outcome...
November 29, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27879581/matching-procedures-at-the-time-of-immediate-breast-reconstruction-an-american-college-of-surgeons-national-surgical-quality-improvement-program-study-of-24-191-patients
#5
Carisa M Cooney, Mohamad E Sebai, Onyebuchi Ogbuagu, Chris Devulapalli, Michele A Manahan, Gedge D Rosson
BACKGROUND: The purpose of this study was to assess for compounded risk of postoperative morbidity with the addition of a simultaneous contralateral breast matching procedure at the time of mastectomy and immediate breast reconstruction. METHODS: 2005 to 2012 American College of Surgeons National Surgical Quality Improvement Program databases were used to identify cases of mastectomy and immediate breast reconstruction with and without simultaneous contralateral breast matching procedures...
December 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27876481/physical-effects-of-unilateral-mastectomy-on-spine-deformity
#6
Savaş Serel, Zeynep Yasavur Tuzlalı, Zehra Akkaya, Çağlar Uzun, Burak Kaya, Sancar Bayar
OBJECTIVE: Mastectomy is known to effect body posture after a change in the center of gravity of women due to a missing breast. Although previous studies on short-term postural changes in mastectomy patients using photogrammetry or Moiré topography suggested ipsilateral inclination of the trunk, our clinical observations during breast reconstruction surgeries indicated a contralateral shoulder elevation in women with unilateral mastectomy. Because the change in body posture can affect spinal alignment, we aimed to evaluate the long-term physical effects of unilateral mastectomy on spine deformity by radiographic examination...
October 26, 2016: Clinical Breast Cancer
https://www.readbyqxmd.com/read/27869081/long-term-update-of-nrg-oncology-rtog-0319-a-phase-1-and-2%C3%A2-trial-to-evaluate-3-dimensional-conformal-radiation-therapy-confined-to-the-region-of%C3%A2-the%C3%A2-lumpectomy-cavity-for-stage-i-and-ii-breast%C3%A2-carcinoma
#7
Rachel Rabinovitch, Jennifer Moughan, Frank Vicini, Helen Pass, John Wong, Susan Chafe, Ivy Petersen, Douglas W Arthur, Julia White
PURPOSE: NRG Oncology RTOG 0319 was the first cooperative group trial in the United States to evaluate 3-dimensional conformal radiation therapy (3D-CRT) accelerated partial breast irradiation (APBI). This report updates secondary endpoints of toxicity and efficacy. METHODS AND MATERIALS: Patients with stage I or II invasive breast cancer (tumor size ≤3 cm, ≤3 positive lymph nodes, negative margins) were eligible for 3D-CRT APBI: 38.5 Gy in 10 twice-daily fractions...
December 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27861758/method-of-breast-reconstruction-and-the-development-of-lymphoedema
#8
K-T Lee, S I Bang, J-K Pyon, J H Hwang, G-H Mun
BACKGROUND: Several studies have demonstrated an association between immediate autologous or implant-based breast reconstruction and a reduced incidence of lymphoedema. However, few of these have focused specifically on whether the reconstruction method affects the development of lymphoedema. The study evaluated the potential impact of breast reconstruction modality on the incidence of lymphoedema. METHODS: Outcomes of women with breast cancer who underwent mastectomy and immediate reconstruction using an autologous flap or a tissue expander/implant between 2008 and 2013 were reviewed...
November 14, 2016: British Journal of Surgery
https://www.readbyqxmd.com/read/27815748/a-model-for-individualized-risk-prediction-of-contralateral-breast-cancer
#9
Marzana Chowdhury, David Euhus, Tracy Onega, Swati Biswas, Pankaj K Choudhary
PURPOSE: Patients diagnosed with invasive breast cancer (BC) or ductal carcinoma in situ are increasingly choosing to undergo contralateral prophylactic mastectomy (CPM) to reduce their risk of contralateral BC (CBC). This is a particularly disturbing trend as a large proportion of these CPMs are believed to be medically unnecessary. Many BC patients tend to substantially overestimate their CBC risk. Thus, there is a pressing need to educate patients effectively on their CBC risk. We develop a CBC risk prediction model to aid physicians in this task...
November 4, 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27800186/modified-lower-pole-autologous-dermal-sling-for-implant-reconstruction-in-women-undergoing-immediate-breast-reconstruction-after-mastectomy
#10
Pankaj G Roy
Background. Autologous dermal sling with wise pattern skin reducing mastectomy allows one-stage implant reconstruction in women with large and ptotic breasts needing mastectomy for cancer or risk reduction. However, this technique is not suitable for women who lack ptosis and also carries risk of T-junction breakdown. Method. We have performed one-stage nipple sparing mastectomies with implant reconstruction in 5 women (8 breasts) by modifying the autologous dermal sling approach. All these women had small to moderate breasts with no ptosis or pseudoptosis...
2016: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/27787313/new-advisory-on-contralateral-prophylactic-mastectomy
#11
Joan Zolot
Breast surgeons recommend against the procedure unless cancer risk is increased.
November 2016: American Journal of Nursing
https://www.readbyqxmd.com/read/27783164/guidelines-for-guidelines-an-assessment-of-the-american-society-of-breast-surgeons-contralateral-prophylactic-mastectomy-consensus-statement
#12
EDITORIAL
Todd M Tuttle, Andrea V Barrio, V Suzanne Klimberg, Armando E Giuliano, Mariana Chavez-MacGregor, Heather A Thompson Buum, Kelly M McMasters
No abstract text is available yet for this article.
October 25, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27779988/is-sentinel-lymph-node-dissection-necessary-in-all-patients-with-ductal-carcinoma-in-situ-undergoing-total-mastectomy
#13
Valentina Bonev, Carlos Chavez De Paz Villanueva, Naveenraj Solomon, Maheswari Senthil, Mark E Reeves, Carlos Garberoglio, Sharon S Lum
When ductal carcinoma in situ (DCIS) is found on core needle biopsy, rates of upgrade to invasive cancer of 25 per cent and nodal positivity of 10 per cent have been reported. Sentinel lymph node dissection (SLND) is recommended when mastectomy is performed for DCIS. We investigated the role of SLND in DCIS patients undergoing partial and total mastectomy (TM). During the study period 2004 to 2013, 170 patients with DCIS were identified with a median age of 60 years (range 26-84 years). Of these, 58.2 per cent had partial mastectomy (PM) alone, 10...
October 2016: American Surgeon
https://www.readbyqxmd.com/read/27771840/comparing-treatment-and-outcomes-of-ductal-carcinoma-in-situ-among-women-in-missouri-by-race
#14
Chinwe C Madubata, Ying Liu, Melody S Goodman, Shumei Yun, Jennifer Yu, Min Lian, Graham A Colditz
PURPOSE: To investigate whether treatment (surgery, radiation therapy, and endocrine therapy) contributes to racial disparities in outcomes of ductal carcinoma in situ (DCIS). PATIENTS AND METHODS: The analysis included 8184 non-Hispanic White and 954 non-Hispanic Black women diagnosed with DCIS between 1996 and 2011 and identified in the Missouri Cancer Registry. Logistic regression models were used to estimate odds ratios (ORs) of treatment for race. We used Cox proportional hazards regression models to estimate hazard ratios (HRs) of ipsilateral breast tumor (IBT) and contralateral breast tumor (CBT) for race...
October 22, 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27730018/aesthetic-outcomes-of-inframammary-fold-recreation-in-two-stage-implant-based-breast-reconstruction
#15
Koichi Tomita, Kenji Yano, Akimitsu Nishibayashi, Shien Seike, Ko Hosokawa
BACKGROUND: When the inframammary fold (IMF) is excised in mastectomy procedures for oncologic reasons, it must be recreated to restore a natural breast shape. Despite refinements in surgical techniques, postoperative loss of a well-defined IMF can occur. This study aimed to assess the outcomes of IMF recreation after two-stage, implant-based breast reconstruction. METHODS: We retrospectively reviewed 75 consecutive patients who underwent unilateral, two-stage, implant-based breast reconstruction between 2013 and 2015 at the authors' institution...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27718437/extreme-oncoplastic-breast-surgery-a-case-report
#16
Daniele Bordoni, Pierfrancesco Cadenelli, Giuseppe Falco, Nicola Rocco, Paola Manna, Ariel Tessone, Matteo Ornelli, Cesare Magalotti
INTRODUCTION: So called "extreme oncoplastic surgery" is emerging as a new promising concept in breast cancer surgery allowing successful breast conservation in selected patients with multicentric tumors. PRESENTATION OF CASE: We report the case of a 48-year-old woman presenting with a multicentric breast cancer and successfully treated with an oncoplastic technique consisting in three radical lumpectomies followed by breast reshaping and simultaneous contralateral symmetrization...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27689057/a-novel-nipple-reconstruction-technique-for-maintaining-nipple-projection-the-boomerang-flap
#17
Young-Eun Kim, Ki Yong Hong, Kyung Won Minn, Ung Sik Jin
Nipple-areolar complex (NAC) reconstruction is the final step in the long journey of breast reconstruction for mastectomy patients. Successful NAC reconstruction depends on the use of appropriate surgical techniques that are simple and reliable. To date, numerous techniques have been used for nipple reconstruction, including contralateral nipple sharing and various local flaps. Recently, it has been common to utilize local flaps. However, the most common nipple reconstruction problem encountered with local flaps is the loss of nipple projection; there can be approximately 50% projection loss in reconstructed nipples over long-term follow-up...
September 2016: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/27674591/contralateral-breast-cancer-risk-and-the-selection-of-contralateral-prophylactic-mastectomy-among-women-with-unilateral-breast-cancer
#18
J V Hegde, J Wang, A Kusske, S A McCloskey
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27650678/outcomes-of-contralateral-prophylactic-mastectomy-in-relation-to-familial-history-a-decision-analysis-brcr-d-16-00033
#19
Kalatu R Davies, Abenaa M Brewster, Isabelle Bedrosian, Patricia A Parker, Melissa A Crosby, Susan K Peterson, Yu Shen, Robert J Volk, Scott B Cantor
BACKGROUND: Family history of breast cancer is associated with an increased risk of contralateral breast cancer (CBC) even in the absence of mutations in the breast cancer susceptibility genes BRCA1/2. We compared quality-adjusted survival after contralateral prophylactic mastectomy (CPM) with surveillance only (no CPM) among women with breast cancer incorporating the degree of family history. METHODS: We created a microsimulation model for women with first-degree, second-degree, and no family history treated for a stage I, II, or III estrogen receptor (ER)-positive or ER-negative breast cancer at the ages of 40, 50, 60, and 70...
2016: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/27624164/subsequent-risk-of-ipsilateral-and-contralateral-invasive-breast-cancer-after-treatment-for-ductal-carcinoma-in-situ-incidence-and-the-effect-of-radiotherapy-in-a-population-based-cohort-of-10-090-women
#20
Lotte E Elshof, Michael Schaapveld, Marjanka K Schmidt, Emiel J Rutgers, Flora E van Leeuwen, Jelle Wesseling
PURPOSE: To assess the effect of different treatment strategies on the risk of subsequent invasive breast cancer (IBC) in women diagnosed with ductal carcinoma in situ (DCIS). METHODS: Up to 15-year cumulative incidences of ipsilateral IBC (iIBC) and contralateral IBC (cIBC) were assessed among a population-based cohort of 10,090 women treated for DCIS in the Netherlands between 1989 and 2004. Multivariable Cox regression analyses were used to evaluate associations of treatment with iIBC risk...
October 2016: Breast Cancer Research and Treatment
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