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https://www.readbyqxmd.com/read/28530067/-stereotactic-ablative-body-radiation-sabr-a-new-therapeutic-option-for-treatment-of-stage-i-lung-cancer
#1
REVIEW
Sarit Appel, Zvi Symon
Stereotactic ablative radiotherapy (SABR) also known as stereotactic body radiation therapy (SBRT) offers a new therapeutic option for stage 1 lung cancer that cannot undergo surgery due to co-morbidities or patient refusal. This treatment evolved in the last decade thanks to technologic advancement of radiation therapy planning and delivery that allow real time imaging of the tumor and real time position correction before every treatment. Ultra high doses of radiation cause ablation of the target with very low collateral scatter dose to surrounding tissue...
November 2016: Harefuah
https://www.readbyqxmd.com/read/28529896/advances-in-radiotherapy-techniques-and-delivery-for-non-small-cell-lung-cancer-benefits-of-intensity-modulated-radiation-therapy-proton-therapy-and-stereotactic-body-radiation-therapy
#2
REVIEW
Tejan P Diwanji, Pranshu Mohindra, Melissa Vyfhuis, James W Snider, Chaitanya Kalavagunta, Sina Mossahebi, Jen Yu, Steven Feigenberg, Shahed N Badiyan
The 21st century has seen several paradigm shifts in the treatment of non-small cell lung cancer (NSCLC) in early-stage inoperable disease, definitive locally advanced disease, and the postoperative setting. A key driver in improvement of local disease control has been the significant evolution of radiation therapy techniques in the last three decades, allowing for delivery of definitive radiation doses while limiting exposure of normal tissues. For patients with locally-advanced NSCLC, the advent of volumetric imaging techniques has allowed a shift from 2-dimensional approaches to 3-dimensional conformal radiation therapy (3DCRT)...
April 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/28526192/comparison-of-spinal-stereotactic-body-radiotherapy-sbrt-planning-techniques-intensity-modulated-radiation-therapy-modulated-arc-therapy-and-helical-tomotherapy
#3
Jina Kim, Hong Seok Jang, Yeon Sil Kim, Byung Ock Choi, Young-Nam Kang
Stereotactic body radiotherapy (SBRT) delivers a highly conformal, hypofractionated radiation dose to a small target with minimal radiation applied to the surrounding areas. Therefore, using the proper treatment planning techniques for SBRT is important. Intensity modulation techniques, such as static intensity-modulated radiation therapy (IMRT), modulated arc therapy (mARC), and helical tomotherapy (HT), are useful for spinal SBRT because of a rapid dose fall-off and spinal cord avoidance. This study compared the planning characteristics for hypofractionated spinal SBRT administered using 3 treatment techniques...
May 16, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28523157/impact-of-maximum-standardized-uptake-value-of-non-small-cell-lung-cancer-on-detecting-lymph-node-involvement-in-potential-stereotactic-body-radiotherapy-candidates
#4
Shanyuan Zhang, Shaolei Li, Yuquan Pei, Miao Huang, Fangliang Lu, Qingfeng Zheng, Nan Li, Yue Yang
BACKGROUND: The retrospective study investigated the association between the maximum standardized uptake value (SUVmax) of primary tumor and lymph node involvement in potential stereotactic body radiotherapy (SBRT) candidates. METHODS: A total of 185 patients with clinical stage I NSCLC were enrolled in the current study. All patients underwent lobectomy with systematic lymph node dissection following preoperative FDG-PET/CT scanning. The association between clinicopathological variables and lymph node involvement was analyzed by univariate and multivariate analysis...
April 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28514930/hypofractionated-stereotactic-body-radiotherapy-for-localized-prostate-cancer-first-nordic-clinical-experience
#5
Kristiina Koskela, Jan-Erik Palmgren, Janne Heikkilä, Heli Virsunen, Liisa Sailas, Päivi Auvinen, Jan Seppälä, Vesa Kataja
BACKGROUND: The use of hypofractionated stereotactic body radiotherapy (SBRT) as primary treatment modality in clinically localized prostate cancer (PCa) is emerging, because the low α/β-ratio favors the use of high dose per fraction in PCa. There is a need for more data about SBRT, especially in high-risk PCa patients. The purpose of this retrospective study was to evaluate the safety and the short-term efficacy of robotic SBRT in a clinical patient cohort with localized PCa including also high-risk patients (D'Amico risk stratification)...
July 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28513855/technical-note-system-for-evaluating-local-hypothermia-as-a-radioprotector-of-the-rectum-in-a-small-animal-model
#6
Brian A Hrycushko, Chenchen Bing, Cecil Futch, Michelle Wodzak, Strahinja Stojadinovic, Paul M Medin, Rajiv Chopra
PURPOSE: The protective effects of induced or even accidental hypothermia on the human body are widespread with several medical uses currently under active research. In vitro experiments using human cell lines have shown hypothermia provides a radioprotective effect that becomes more pronounced at large, single-fraction doses common to stereotactic body radiotherapy (SBRT) and stereotactic radiosurgery (SRS) treatments. This work describes the development of a system to evaluate local hypothermia for a radioprotive effect of the rat rectum during a large dose of radiation relevant to prostate SBRT...
May 17, 2017: Medical Physics
https://www.readbyqxmd.com/read/28507888/spine-stereotactic-body-radiotherapy-indications-outcomes-and-points-of-caution
#7
Chia-Lin Tseng, Wietse Eppinga, Raphaele Charest-Morin, Hany Soliman, Sten Myrehaug, Pejman Jabehdar Maralani, Mikki Campbell, Young K Lee, Charles Fisher, Michael G Fehlings, Eric L Chang, Simon S Lo, Arjun Sahgal
STUDY DESIGN: A broad narrative review. OBJECTIVES: The objective of this article is to provide a technical review of spine stereotactic body radiotherapy (SBRT) planning and delivery, indications for treatment, outcomes, complications, and the challenges of response assessment. The surgical approach to spinal metastases is discussed with an overview of emerging minimally invasive techniques. METHODS: A comprehensive review of the literature was conducted on the techniques, outcomes, and developments in SBRT and surgery for spinal metastases...
April 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28507460/validation-of-the-liver-mean-dose-in-terms-of-the-biological-effective-dose-for-the-prevention-of-radiation-induced-liver-damage
#8
Hiroshi Doi, Norihisa Masai, Kenji Uemoto, Osamu Suzuki, Hiroya Shiomi, Daisaku Tatsumi, Ryoong-Jin Oh
AIM: The purpose of this study was to determine the optimal mean liver biologically effective dose (BED) to prevent radiation-induced liver disease (RILD) in stereotactic body radiation therapy (SBRT). BACKGROUND: The actual mean doses appropriate for liver irradiation in modern radiotherapy techniques have not been adequately investigated, although SBRT is sometimes alternatively performed using fractionated regimens. MATERIALS AND METHODS: SBRT treatment plans for liver tumors in 50 patients were analyzed...
July 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28503898/evaluation-of-initial-setup-errors-of-two-immobilization-devices-for-lung-stereotactic-body-radiation-therapy-sbrt
#9
Yoshihiro Ueda, Teruki Teshima, Higinia Cárdenes, Indra J Das
The aim of this study was to investigate the accuracy and efficacy of two commonly used commercial immobilization systems for stereotactic body radiation therapy (SBRT) in lung cancer. This retrospective study assessed the efficacy and setup accuracy of two immobilization systems: the Elekta Body Frame (EBF) and the Civco Body Pro-Lok (CBP) in 80 patients evenly divided for each system. A cone beam CT (CBCT) was used before each treatment fraction for setup correction in both devices. Analyzed shifts were applied for setup correction and CBCT was repeated...
May 14, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28493847/cost-utility-of-stereotactic-radiation-therapy-versus-proton-beam-therapy-for-inoperable-advanced-hepatocellular-carcinoma
#10
Henry W C Leung, Agnes L F Chan
The cost-utility of proton beam therapy was compared to stereotactic body radiation therapy for inoperable advanced hepatocellular carcinoma. A Markov decision-analytic model was performed following time to progression and survival using phase II trial data. Patients transitioned between three health states. Clinical outcomes were estimated for quality of life using utility estimates in the published literature and measured as incremental cost-effectiveness ratios (ICERs) and net monetary benefits (NMBs). Real direct medical costs were extracted from the Bureau of National Health Insurance database...
April 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28493288/outcomes-for-patients-with-locally-advanced-pancreatic-adenocarcinoma-treated-with-stereotactic-body-radiation-therapy-versus-conventionally-fractionated-radiation
#11
Jim Zhong, Kirtesh Patel, Jeffrey Switchenko, Richard J Cassidy, William A Hall, Theresa Gillespie, Pretesh R Patel, David Kooby, Jerome Landry
BACKGROUND: As systemic therapy has improved for locally advanced pancreatic cancer (LAPC), efforts to improve local control with optimal radiotherapy may be critical. Although conventionally fractionated radiation therapy (CFRT) has more recently shown a limited role in LAPC, stereotactic body radiation therapy (SBRT) is an emerging approach with promising results. With no studies to date comparing SBRT with CFRT for LAPC, this study used the National Cancer Data Base (NCDB) to evaluate these 2 modalities...
May 10, 2017: Cancer
https://www.readbyqxmd.com/read/28490989/evaluation-of-response-after-sbrt-for-liver-tumors
#12
Raphael Tétreau, Carmen Llacer, Olivier Riou, Emmanuel Deshayes
Stereotactic body radiotherapy (SBRT) has developed over the last few years for the treatment of primary and metastatic hepatic tumors. The tumoral and adjacent peritumoral modifications caused by this radiosurgery limit the evaluation of response by anatomic imaging and dimensional criteria alone, such as with RECIST. This suggests that it is of interest to also take into account the residual enhancement and hyper metabolism of these hepatic targets. We have reviewed the English language literature regarding the response of hepatic lesions treated by SBRT, and found that only seven articles were specifically concerned with this problem...
March 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28490988/the-role-of-sbrt-in-oligometastatic-patients-with-liver-metastases-from-breast-cancer
#13
Marta Scorsetti, Davide Franceschini, Fiorenza De Rose, Tiziana Comito, Ciro Franzese, Giovanna Masci, Rosalba Torrisi, Luca Viganò, Guido Torzilli
Liver metastases from breast cancer are a common occurrence. Local ablative therapies are a promising therapeutic option for these patients, with the potential for a long term disease control in the setting of "oligometastatic patients". Identification of the perfect candidate for local approaches is still challenging and unclear. Stereotactic body radiation therapy (SBRT) is one of the most valuable local therapy, because of great efficiency, low morbidity and minimal invasiveness. In this paper, we reviewed the state of the art in the care of breast cancer patients with liver metastases, with a focus on SBRT...
March 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28490987/stereotactic-body-radiation-therapy-for-liver-metastasis-the-linac-based-greater-poland-cancer-centre-practice
#14
Magdalena Fundowicz, Marta Adamczyk, Anna Kołodziej-Dybaś
AIM: The main purpose of this work is to give a technical description and present the properties of the liver SBRT protocol implemented in the Greater Poland Cancer Centre (GPCC) in Poznan, Poland. BACKGROUND: Stereotactic body radiation therapy (SBRT) for liver metastasis is a non-invasive therapeutic option which enables irradiation of a small target in the body with a high dose. MATERIALS AND METHODS: This study presents details of our linac-based liver SBRT protocol...
March 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28490986/image-guided-sbrt-for-multiple-liver-metastases-with-exactrac-%C3%A2-adaptive-gating
#15
Carmen Rubio, Ovidio Hernando-Requejo, Daniel Zucca Aparicio, María ALlona Krauel, Mercedes López Gonzalez, Juan María Pérez, Emilio Sánchez Saugar, Pedro Fernández Letón
AIM: To report the outcome and toxicity of sequential stereotactic body radiotherapy (SBRT) for multiple liver metastases in patients treated with ExacTrac Adaptive Gating. BACKGROUND: In selected patients with a limited number of liver metastases, SBRT has been evaluated as a safe and effective treatment, with minimal toxicity and high rates of local control. MATERIALS AND METHODS: From April 2008 to October 2013, 21 patients with multiple (3-14) liver metastases (n = 101) were treated sequentially with SBRT at our institution...
March 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28490985/imaged-guided-liver-stereotactic-body-radiotherapy-using-vmat-and-real-time-adaptive-tumor-gating-concerns-about-technique-and-preliminary-clinical-results
#16
Carmen Llacer-Moscardo, Olivier Riou, David Azria, Ludovic Bedos, Norbert Ailleres, Francois Quenet, Philippe Rouanet, Marc Ychou, Pascal Fenoglietto
BACKGROUND: Motion management is a major challenge in abdominal SBRT. We present our study of SBRT for liver tumors using intrafraction motion review (IMR) allowing simultaneous KV information and MV delivery to synchronize the beam during gated RapidArc treatment. MATERIALS AND METHODS: Between May 2012 and March 2015, 41 patients were treated by liver SBRT using gated RapidArc technique in a Varian Novalis Truebeam STx linear accelerator. PTV was created by expanding 5 mm from the ITV...
March 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28490984/evaluation-of-reproducibility-of-tumor-repositioning-during-multiple-breathing-cycles-for-liver-stereotactic-body-radiotherapy-treatment
#17
Ludovic Bedos, Olivier Riou, Norbert Aillères, Antoine Braccini, Jessica Molinier, Carmen Llacer Moscardo, David Azria, Pascal Fenoglietto
AIM: To evaluate the tumor repositioning during gated volumetric modulated arc therapy (VMAT) for liver stereotactic body radiotherapy(SBRT) treatment using implanted fiducial markers and intrafraction kilovoltage (kV) images acquired during dose delivery. MATERIALS AND METHODS: Since 2012, 47 liver cancer patients with implanted fiducial markers were treated using the gated VMAT technique with a Varian Truebeam STx linear accelerator. The fiducial markers were implanted inside or close to the tumor target before treatment simulation...
March 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28490983/institutional-experience-in-the-treatment-of-colorectal-liver-metastases-with-stereotactic-body-radiation-therapy
#18
Alejandra Méndez Romero, Fatma Keskin-Cambay, Rob M van Os, Joost J Nuyttens, Ben J M Heijmen, Jan N M IJzermans, Cornelis Verhoef
AIM: To investigate whether the impact of dose escalation in our patient population represented an improvement in local control without increasing treatment related toxicity. MATERIALS AND METHODS: A cohort of consecutive patients with colorectal liver metastases treated with stereotactic body radiation therapy (SBRT) between December 2002 and December 2013 were eligible for this study. Inclusion criteria were a Karnofsky performance status ≥80% and, according to the multidisciplinary tumor board, ineligibility for surgery or radiofrequency ablation...
March 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28490982/radiosurgery-for-liver-metastases-a-single-institution-experience
#19
Beatriz Amendola, Marco Amendola, Jesús M Blanco, Naipy Perez, Xiaodong Wu
AIM: To report our initial results on the use of radiosurgery for treatment of liver metastases. BACKGROUND: In recent years there has been increasing interest in the use of stereotactic body radiation therapy to treat metastatic disease to the liver as an alternative to interventional procedures. MATERIALS AND METHODS: Between November 2008 and June 2015 a total of 36 LINAC-based radiosurgeries using VMAT were performed in 27 patients with liver metastases from 10 different primary sites...
March 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28490981/robotic-radiosurgery-for-the-treatment-of-liver-metastases
#20
Rafael García, Iciar Santa-Olalla, Jose Luis Lopez Guerra, Silvia Sanchez, Ignacio Azinovic
AIM: This study evaluates the toxicity and outcome in patients treated with robotic radiosurgery for liver metastases. BACKGROUND: Modern technologies allow the delivery of high doses to the liver metastases while lowering the dose to the neighboring organs at risk. Whether this dosimetric advantage translates into clinical benefit is not well known yet. METHODS AND MATERIALS: A total of 9 patients with 17 liver metastases have been treated with robotic stereotactic body radiotherapy SBRT from March 2011 to December 2014...
March 2017: Reports of Practical Oncology and Radiotherapy
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