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Chia-Lin Tseng, Hany Soliman, Sten Myrehaug, Young K Lee, Mark Ruschin, Eshetu G Atenafu, Mikki Campbell, Pejman Maralani, Victor Yang, Albert Yee, Arjun Sahgal
OBJECTIVES: We report mature outcomes for a cohort of patients with no prior radiation (de novo) to the spine treated with 24 Gy in 2 daily fractions for metastases, which represents the SBRT regimen under evaluation on the current SC-24 phase 3 randomized trial (NCT02512965). METHODS: The cohort consisted of 279 de novo spinal metastases in 145 consecutive patients treated with 24 Gy in 2 SBRT fractions, identified from a prospective single-institution database...
July 9, 2018: International Journal of Radiation Oncology, Biology, Physics
Filippo Alongi, Rosario Mazzola, Alba Fiorentino, Stefanie Corradini, Dario Aiello, Vanessa Figlia, Fabiana Gregucci, Riccardo Ballario, Stefano Cavalleri, Ruggero Ruggieri
AIM: The goal was to evaluate feasibility, side effects and biochemical no evidence of disease (bNED) after stereotactic body radiation therapy (SBRT) delivered on 5 consecutive days for localized prostate cancer (PC). METHODS: The study was approved by the ethical committee and started in March 2014. Inclusion criteria were age ≤85 years, WHO performance status ≤2, histologically proven adenocarcinoma, low-intermediate risk, no previous surgery (except transurethral resection of the prostate), and a pre-SBRT International Prostatic Symptoms Score of 0-7...
July 12, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
Li Rebekah Feng, Simeng Suy, Sean P Collins, Jonathan W Lischalk, Berwin Yuan, Leorey N Saligan
Background: Prostate cancer survivors commonly experience late-onset lower urinary tract symptoms following radiotherapy. We aimed to compare lower urinary tract symptoms in patients treated with stereotactic body radiotherapy (SBRT) to those treated with a combination of lower dose SBRT and supplemental intensity-modulated radiotherapy (SBRT + IMRT). Methods: Subjects with localized prostate carcinoma scheduled to receive SBRT or a combination of SBRT and IMRT were enrolled and followed for up to 2 years after treatment completion...
June 2018: Current Urology
Fan-Tu Kong, Yan-Hua Mai, Meng-Ke Qi, Ai-Qian Wu, Fu-Tong Guo, Qi-Yuan Jia, Yong-Bao Li, Ting Song, Ling-Hong Zhou
OBJECTIVE: To establish the association between the geometric anatomical characteristics of the patients and the corresponding three-dimensional (3D) dose distribution of radiotherapy plan via feed-forward back-propagation neural network for clinical prediction of the plan dosimetric features. METHODS: A total of 25 fixed 13-field clinical prostate cancer intensity-modulated radiation therapy (IMRT)/stereotactic body radiation therapy (SBRT) plans were collected with a prescribed dose of 50 Gy...
June 20, 2018: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
Fausto Petrelli, Tiziana Comito, Sandro Barni, Gianfranco Pancera, Marta Scorsetti, Antonio Ghidini
INTRODUCTION: While surgery is the preferred option for isolated, operable liver metastases from colorectal cancer (CRC), ablative techniques are endorsed for medically or technically inoperable lesions. Stereotactic body radiotherapy (SBRT) is an alternative ablative local therapy that delivers high RT doses in a few fractions to the cancer, sparing surrounding critical tissue. We have performed a systematic review of published trials to evaluate the efficacy of SBRT as a primary modality therapy for CRC liver oligometastases...
July 9, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Yeon Joo Kim, Su Ssan Kim, Si Yeol Song, Eun Kyung Choi
BACKGROUND: Combined stereotactic body radiotherapy (SBRT) for lung lesions and conventional radiotherapy (CRT) for nodal areas may be more effective than CRT alone in patients with locally advanced lung cancer. METHODS: This study included 21 patients with small primary lung tumors distant from the regional nodal areas. The SBRT dose was 40-60 Gy in 4 fractions. CRT doses were 66 Gy in 30 fractions for non-small cell lung cancer and 52.5 Gy in 25 fractions for small cell lung cancer...
July 11, 2018: Radiation Oncology
Mauro Loi, Michael Frelinghuysen, Natalie Desiree Klass, Esther Oomen-De Hoop, Patrick Vincent Granton, Joachim Aerts, Cornelis Verhoef, Joost Nuyttens
Stereotactic body radiotherapy (SBRT) has emerged as an effective option in oligo-metastatic cancer patients affected by lymph node metastases, but its use might be questioned due to risk of regional and distant dissemination through the lymph node chain. The primary aim of our study was to assess the loco-regional control following SBRT in this setting. Ninety-one patients undergoing SBRT for at least one lymph node metastasis from miscellaneous primary tumors were retrospectively evaluated for patterns of failure and toxicity...
July 11, 2018: Clinical & Experimental Metastasis
Hann-Hsiang Chao, Gilmer Valdes, Jose M Luna, Marina Heskel, Abigail T Berman, Timothy D Solberg, Charles B Simone
BACKGROUND AND PURPOSE: Chest wall toxicity is observed after stereotactic body radiation therapy (SBRT) for peripherally located lung tumors. We utilize machine learning algorithms to identify toxicity predictors to develop dose-volume constraints. MATERIALS AND METHODS: Twenty-five patient, tumor, and dosimetric features were recorded for 197 consecutive patients with Stage I NSCLC treated with SBRT, 11 of whom (5.6%) developed CTCAEv4 grade ≥2 chest wall pain...
July 10, 2018: Journal of Applied Clinical Medical Physics
Oliver E Holmes, Julie Gratton, Janos Szanto, Eric Vandervoort, Janice Doody, Elizabeth Henderson, Scott C Morgan, Joseph O'Sullivan, Shawn Malone
Purpose: Ultra-hypofractionated radiotherapy with SBRT is an established technique for treating localized prostate cancer. CyberKnife based SBRT requires implantation of fiducial markers for soft tissue target tracking by the orthogonal KV X-ray imaging system. The spatial distribution of fiducial markers must allow accurate calculation of a 3D transformation that describes the position of the prostate within the reference frame of the planning CT scan. Accuray provides a fiducial implantation guideline for tracking soft tissue lesions...
2018: Journal of Radiosurgery and SBRT
Sameera S Kumar, Logan Hall, Xingzhe Li, Laura Downes, Andrew Shearer, Brent J Shelton, Samuel Gerring, Ronald C McGarry
Purpose/objectives: Since the inception of stereotactic body radiation therapy (SBRT), treatment delivery has been performed with volumetric modulated arc therapy (VMAT), helical tomotherapy (HT) and noncoplanar static fields (SF). The purpose of this study is to compare SBRT delivery among these treatment modalities to the lung. Materials/methods: A retrospective review of SBRT treatments of 30 to 60 Gy in 1 to 5 fractions from 2007 to 2015 was performed. Dosimetric parameters included V5, V20, D2cm, gross tumor volume (GTV) and planning target volume (PTV) size and coverage, rib/esophageal minimum/maximum doses, R30Gy, R50%, and the conformality index (CI)...
2018: Journal of Radiosurgery and SBRT
Lijun Ma, Lei Wang, Young Lee, Chia-Lin Tseng, Scott Soltys, Steve Braunstein, Arjun Sahgal
Purpose: Doses to small spinal cord isodose volume (such as those ranging from Dmax 0.0 cc to 0.5 cc) as well as to large volumes (such as those ranging from 0.5 cc to 3.0 cc) are critical parameters to guide safe practice of spine SBRT. We here report a mathematical formula that links the most probable dose volume limits together for common spine SBRT cases.Methods and materials: A dose ripple formula parameterized with equivalent dose radius (EDR) was derived to model spinal cord small-volume doses for a spine SBRT treatment...
2018: Journal of Radiosurgery and SBRT
Thinh Chau, Allan Y Chen
In patients with lung malignancy, the development of malignant hypercalcemia (MH) carries a dismal prognosis and represents a major therapeutic challenge given that conventional medical treatments have limited durability. Robust and lasting hypercalcemic reversal and symptomatic relief have been documented following surgical tumor resection. Stereotactic body radiation therapy (SBRT) has emerged as an effective treatment modality in medically inoperable patients with Stage I non-small cell lung cancer (NSCLC)...
2018: Journal of Radiosurgery and SBRT
Yoshiyuki Shioyama, Hiroshi Onishi, Kenji Takayama, Yukinori Matsuo, Atsuya Takeda, Hideomi Yamashita, Akifumi Miyakawa, Naoya Murakami, Masahiko Aoki, Haruo Matsushita, Yasuo Matsumoto, Yuta Shibamoto
Stereotactic body radiotherapy (SBRT) is widely used as a curative treatment option for stage I non-small-cell lung cancer, but for patients with stage I small-cell lung cancer, the role of stereotactic body radiotherapy is unclear. In this study, we retrospectively analyzed the outcomes of a subset of patients with stage I small-cell lung cancer treated with stereotactic body radiotherapy in the database of the Japanese Radiological Society-Multi-Institutional stereotactic body radiotherapy Study Group. The 43 patients treated with stereotactic body radiotherapy for stage I small-cell lung cancer between 2004 and 2012 at 11 Japanese institutions were studied: median age = 77 years; 32 (74%) males and 11 females; and 80% were medically inoperable...
January 1, 2018: Technology in Cancer Research & Treatment
Kyung Hwa Lee, Jeong Il Yu, Hee Chul Park, Su Yeon Park, Jung Suk Shin, Eun Hyuk Shin, Sungkoo Cho, Sang Hoon Jung, Young Yih Han, Do Hoon Lim
PURPOSE: This study was conducted to compare clinical outcomes and treatment-related toxicities after stereotactic body radiation therapy (SBRT) with two different dose regimens for small hepatocellular carcinomas (HCC) ≤3 cm in size. Materials and. METHODS: We retrospectively reviewed 44 patients with liver-confined HCC treated between 2009 and 2014 with SBRT. Total doses of 45 Gy (n = 10) or 60 Gy (n = 34) in 3 fractions were prescribed to the 95% isodose line covering 95% of the planning target volume...
June 2018: Radiation Oncology Journal
Seung Hyuck Jeon, Jin Ho Kim
PURPOSE: To investigate positional uncertainty and its correlation with clinical parameters in spine stereotactic body radiotherapy (SBRT) using thermoplastic mask (TM) immobilization. Materials and. METHODS: A total of 21 patients who underwent spine SBRT for cervical or upper thoracic spinal lesions were retrospectively analyzed. All patients were treated with image guidance using cone beam computed tomography (CBCT) and 4 degrees-of-freedom (DoF) positional correction...
June 2018: Radiation Oncology Journal
Tamim Niazi, Sara Elakshar, Gabriela Stroian
PURPOSE OF REVIEW: The oligometastases is considered an intermediate state of the disease between localized and wide spread metastases. Local ablative therapy to oligometastatic prostate cancer is gaining significant traction and stereotactic body radiotherapy (SBRT) is an emerging treatment modality for this patient population. In this review, we report our literature review of SBRT to prostate oligometastases. Current evidence on the role of SBRT in oligometastatic prostate cancer reported in the last 10 years was summarized...
July 3, 2018: Current Opinion in Supportive and Palliative Care
J Martin Brown
No abstract text is available yet for this article.
July 15, 2018: International Journal of Radiation Oncology, Biology, Physics
Louise J Murray, Jenna Sykes, James Brierley, John J Kim, Rebecca K S Wong, Jolie Ringash, Tim Craig, Michael Velec, Patricia Lindsay, Jennifer J Knox, Laura A Dawson
PURPOSE: To assess the baseline albumin-bilirubin (ALBI) score as a predictor of toxicity and survival in a prospective cohort of Western patients with hepatocellular carcinoma (HCC) treated with stereotactic body radiation therapy (SBRT) in 2 prospective trials. METHODS AND MATERIALS: The study included 102 patients with Child-Pugh class A liver disease who received 6-fraction SBRT for HCC. Univariate and multivariable logistic regression investigated factors associated with toxicity, defined as an increase in Child-Pugh score ≥ 2 within 3 months of SBRT...
July 15, 2018: International Journal of Radiation Oncology, Biology, Physics
Dingyi Zhou, Hong Quan, Di Yan, Shupeng Chen, An Qin, Carl Stanhope, Martin Lachaine, Jian Liang
PURPOSE: To investigate the intrafractional stability of the motion relationship between the diaphragm and tumor, as well as the feasibility of using diaphragm motion to estimate lung tumor motion. METHODS: Eighty-five paired (pre and posttreatment) daily 4D-CBCT images were obtained from 20 lung cancer patients who underwent SBRT. Bony registration was performed between the pre- and post-CBCT images to exclude patient body movement. The end-exhalation phase image of the pre-CBCT image was selected as the reference image...
July 3, 2018: Journal of Applied Clinical Medical Physics
Linda Rossi, Abdul Wahab Sharfo, Shafak Aluwini, Maarten Dirkx, Sebastiaan Breedveld, Ben Heijmen
BACKGROUND: For conventional radiotherapy treatment units, automated planning can significantly improve plan quality. For robotic radiosurgery, systems for automatic generation of clinically deliverable plans do not yet exist. For prostate stereotactic body radiation therapy (SBRT), few studies have systematically compared VMAT with robotic treatment. MATERIAL AND METHODS: The multi-criteria autoplanning optimizer, developed at our institute, was coupled to the commercial treatment planning system of our robotic treatment unit, for fully automated generation of clinically deliverable plans (autoROBOT)...
July 2, 2018: Acta Oncologica
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