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https://www.readbyqxmd.com/read/28820285/oligometastatic-cancer-stereotactic-ablative-radiotherapy-for-patients-affected-by-isolated-body-metastasis
#1
Andrea Lancia, Gianluca Ingrosso, Alessandra Carosi, Luana Di Murro, Emilia Giudice, Sara Cicchetti, Pasquale Morelli, Daniela di Cristino, Claudia Bruni, Alessandra Murgia, Alessandro Cancelli, Irene Turturici, Anjali Iadevaia, Elisabetta Ponti, Riccardo Santoni
BACKGROUND: To evaluate the outcome of patients affected by a single isolated body metastasis treated with stereotactic body radiotherapy (SBRT). MATERIAL AND METHODS: Seven-eight patients were treated with SBRT for isolated body metastasis. The most frequent primary tumor was prostate cancer (28.2%), followed by colorectal cancer (23.1%) and lung cancer (20.5%). Median age at diagnosis of oligometastatic disease was 70 years (range 47-88). Median Karnofsky Performance Status (KPS) was 90 (range 70-100)...
August 18, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28819766/-german-s3-guideline-for-renal-cell-carcinoma-presentation-and-discussion-of-essential-aspects-for-the-radiation-oncologist
#2
REVIEW
Arndt-Christian Müller, Birgitt van Oorschot, Oliver Micke, Matthias Guckenberger
PURPOSE: We aim to introduce and discuss the statements and recommendations of the German S3 guideline on renal cell cancer for daily practice of radiation oncologists. METHODS: This report comprises indication, treatment decision, dose prescription and current literature including treatment of oligometastatic disease. RESULTS: According to different stages of the disease and the structure of the guideline we focus on five treatment situations and recommendations for decision making: (1) Neo-/adjuvant treatment before or after nephrectomy: No indication for radiotherapy...
August 17, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28812120/risk-adapted-robotic-stereotactic-body-radiation-therapy-for-inoperable-early-stage-non-small-cell-lung-cancer
#3
Susanne Temming, Martin Kocher, Erich Stoelben, Lars Hagmeyer, De-Hua Chang, Konrad Frank, Khosro Hekmat, Juergen Wolf, Wolfgang W Baus, Robert Semrau, Christian Baues, S Marnitz
PURPOSE: To evaluate efficacy and toxicity of stereotactic body radiation therapy (SBRT) with CyberKnife® (Accuray, Sunnyvale, CA, USA) in a selected cohort of primary, medically inoperable early-stage non-small cell lung cancer (NSCLC) patients. METHODS: From 2012 to 2016, 106 patients (median age 74 years, range 50-94 years) with primary NSCLC were treated with SBRT using CyberKnife®. Histologic confirmation was available in 87 patients (82%). For mediastinal staging, 92 patients (87%) underwent (18)F-fluorodeoxyglucose positron-emission tomography (18-FDG-PET) and/or endobronchial ultrasound (EBUS)-guided lymph node biopsy or mediastinoscopy...
August 15, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28802976/prognostic-factors-associated-with-the-accuracy-of-deformable-image-registration-in-lung-cancer-patients-treated-with-stereotactic-body-radiotherapy
#4
Yasuharu Sugawara, Hidenobu Tachibana, Noriyuki Kadoya, Nozomi Kitamura, Amit Sawant, Keiichi Jingu
We evaluated the accuracy of an in-house program in lung stereotactic body radiation therapy (SBRT) cancer patients, and explored the prognostic factors associated with the accuracy of deformable image registrations (DIRs). The accuracy of the 3 programs which implement the free-form deformation and the B-spline algorithm was compared regarding the structures on 4-dimensional computed tomography (4DCT) image datasets between the peak-inhale and peak-exhale phases. The dice similarity coefficient (DSC) and normalized DSC (NDSC) were measured for the gross tumor volumes from 19 lung SBRT patients...
August 9, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28801240/exploring-all-avenues-for-radiotherapy-in-oligorecurrent-prostate-cancer-disease-limited-to-lymph-nodes-a-systematic-review-of-the-role-of-stereotactic-body-radiotherapy
#5
REVIEW
Elisabetta Ponti, Andrea Lancia, Piet Ost, Fabio Trippa, Luca Triggiani, Beatrice Detti, Gianluca Ingrosso
CONTEXT: Stereotactic body radiotherapy (SBRT) is emerging as a treatment option in patients affected by oligorecurrent prostate cancer disease limited to lymph nodes, a subgroup of patients who would otherwise be treated only with androgen deprivation therapy (ADT). OBJECTIVE: To perform a systematic review of SBRT for oligorecurrent prostate cancer limited to lymph nodes. EVIDENCE ACQUISITION: We performed a systematic review of PubMed/Medline in October 2016 according to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA)...
August 8, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28800837/outcomes-of-invasive-mediastinal-nodal-staging-versus-positron-emission-tomography-staging-alone-for-early-stage-non-small-cell-lung-cancer-treated-with-stereotactic-body-radiation-therapy
#6
Caitlin A Schonewolf, Vivek Verma, Carl M Post, Abigail T Berman, Melissa A Frick, Anil Vachani, Chi Lin, Charles B Simone
BACKGROUND: The benefit of invasive mediastinal nodal staging (IMNS) in addition to positron emission tomography-computed tomography (PET/CT) is undefined for early stage non-small cell lung cancer (NSCLC). This multi-institutional investigation aimed to evaluate outcomes and patterns of failure in patients staged with PET/CT with or without additional IMNS. METHODS: Two academic centers assessed all consecutive patients staged with PET/CT for early-stage, primary lung NSCLC (cT1-2aN0M0) treated with SBRT...
July 14, 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28796864/individualized-adaptive-stereotactic-body-radiotherapy-for-liver-tumors-in-patients-at-high-risk-for-liver-damage-a-phase-2-clinical-trial
#7
Mary Feng, Krithika Suresh, Matthew J Schipper, Latifa Bazzi, Edgar Ben-Josef, Martha M Matuszak, Neehar D Parikh, Theodore H Welling, Daniel Normolle, Randall K Ten Haken, Theodore S Lawrence
Importance: Patients with preexisting liver dysfunction could benefit the most from personalized therapy for liver tumors to balance maximal tumor control and minimal risk of liver failure. We designed an individualized adaptive trial testing the hypothesis that adapting treatment based on change in liver function could optimize the therapeutic index for each patient. Objective: To characterize the safety and efficacy of individualized adaptive stereotactic body radiotherapy (SRBT) for liver tumors in patients who have preexisting liver dysfunction...
August 10, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28794640/volumetric-modulated-arc-therapy-for-treatment-of-solid-tumors-current-insights
#8
REVIEW
Gabriella Macchia, Francesco Deodato, Savino Cilla, Silvia Cammelli, Alessandra Guido, Martina Ferioli, Giambattista Siepe, Vincenzo Valentini, Alessio Giuseppe Morganti, Gabriella Ferrandina
AIM: This article discusses the current use of volumetric modulated arc therapy (VMAT) techniques in clinical practice and reviews the available data from clinical outcome studies in different clinical settings. An overview of available literature about clinical outcomes with VMAT stereotactic/radiosurgical treatment is also reported. MATERIALS AND METHODS: All published manuscripts reporting the use of VMAT in a clinical setting from 2009 to November 2016 were identified...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28791252/prostate-specific-antigen-5-years-following-stereotactic-body-radiation-therapy-for-low-and-intermediate-risk-prostate-cancer-an-ablative-procedure
#9
Shaan Kataria, Harsha Koneru, Shan Guleria, Malika Danner, Marilyn Ayoob, Thomas Yung, Siyuan Lei, Brian T Collins, Simeng Suy, John H Lynch, Thomas Kole, Sean P Collins
BACKGROUND: Our previous work on early PSA kinetics following prostate stereotactic body radiation therapy (SBRT) demonstrated that an initial rapid and then slow PSA decline may result in very low PSA nadirs. This retrospective study sought to evaluate the PSA nadir 5 years following SBRT for low- and intermediate-risk prostate cancer (PCa). METHODS: 65 low- and 80 intermediate-risk PCa patients were treated definitively with SBRT to 35-37.5 Gy in 5 fractions at Georgetown University Hospital between January 2008 and October 2011...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28786239/aapm-rss-medical-physics-practice-guideline-9-a-for-srs-sbrt
#10
Per H Halvorsen, Eileen Cirino, Indra J Das, Jeffrey A Garrett, Jun Yang, Fang-Fang Yin, Lynne A Fairobent
The American Association of Physicists in Medicine (AAPM) is a nonprofit professional society whose primary purposes are to advance the science, education, and professional practice of medical physics. The AAPM has more than 8,000 members and is the principal organization of medical physicists in the United States. The AAPM will periodically define new practice guidelines for medical physics practice to help advance the science of medical physics and to improve the quality of service to patients throughout the United States...
August 8, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28786235/submillimeter-alignment-of-more-than-three-contiguous-vertebrae-in-spinal-srs-sbrt-with-6-degree-couch
#11
Xin Wang, Zhongxiang Zhao, Dershan Luo, James N Yang, Jinzhong Yang, Eric L Chang, Paul D Brown, Jing Li, Mary F McAleer, Amol J Ghia
The purpose of this study is to identify regions of spinal column in which more than three contiguous vertebrae can be reliably and quickly aligned within 1 mm using a 6-degree (6D) couch and full body immobilization device. We analyzed 45 cases treated over a 3-month period. Each case was aligned using ExacTrac x-ray positioning system with integrated 6D couch to be within 1° and 1 mm in all six dimensions. Cone-Beam computed tomography (CBCT) with at least 17.5 cm field of view (FOV) in the superior-inferior direction was taken immediately after ExacTrac positioning...
August 8, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28786219/rectal-protection-in-prostate-stereotactic-radiotherapy-a-retrospective-exploratory-analysis-of-two-rectal-displacement-devices
#12
Lee Wilton, Matthew Richardson, Sarah Keats, Kimberley Legge, Mary-Claire Hanlon, Sankar Arumugam, Perry Hunter, Tiffany-Jane Evans, Mark Sidhom, Jarad Martin
INTRODUCTION: High rectal doses are associated with increased toxicity. A rectal displacement device (RDD) reduces rectal dose in prostate stereotactic body radiation therapy (SBRT). This study investigates any dosimetric difference between two methods of rectal displacement (Rectafix and SpaceOAR) for prostate SBRT. METHODS: Rectal dosimetry of 45 men who received SBRT within the PROMETHEUS trial was retrospectively examined, across two radiation therapy centres using the two RDD's...
August 8, 2017: Journal of Medical Radiation Sciences
https://www.readbyqxmd.com/read/28784572/the-influence-of-plan-modulation-on-the-interplay-effect-in-vmat-liver-sbrt-treatments
#13
Emily Hubley, Greg Pierce
Volumetric modulated arc therapy (VMAT) uses multileaf collimator (MLC) leaves, gantry speed, and dose rate to modulate beam fluence, producing the highly conformal doses required for liver radiotherapy. When targets that move with respiration are treated with a dynamic fluence, there exists the possibility for interplay between the target and leaf motions. This study employs a novel motion simulation technique to determine if VMAT liver SBRT plans with an increase in MLC leaf modulation are more susceptible to dosimetric differences in the GTV due to interplay effects...
August 4, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28774760/dosimetric-comparison-of-rectal-sparing-capabilities-of-rectal-balloon-vs-injectable-spacer-gel-in-stereotactic-body-radiation-therapy-for-prostate-cancer-lessons-learned-from-prospective-trials
#14
Ryan T Jones, Nima Hassan Rezaeian, Neil B Desai, Yair Lotan, Xun Jia, Raquibul Hannan, D W Nathan Kim, Brad Hornberger, Jeffrey Dubas, Aaron M Laine, Michael J Zelefsky, Robert D Timmerman, Michael R Folkert
This study aimed to compare the rectal-sparing capabilities of rectal balloons vs absorbable injectable spacer gel in stereotactic body radiation therapy (SBRT) for prostate cancer. Patient samples included in this analysis were obtained from 2 multi-institutional prospective trials of SBRT for prostate cancer using a rectal balloon (n = 36 patients) and injectable spacer gel (n = 36). Treatment prescription dose was 45 Gy in 5 fractions in 42 patients; for equal comparison, the remaining 30 patients were rescaled to 45 Gy from 47...
July 31, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28771144/effect-of-intra-fraction-motion-on-the-accumulated-dose-for-free-breathing-mr-guided-stereotactic-body-radiation-therapy-of-renal-cell-carcinoma
#15
Bjorn Stemkens, Markus Glitzner, Charis Kontaxis, Baudouin Denis de Senneville, Fieke M Prins, Sjoerd P M Crijns, Linda G W Kerkmeijer, Jan J W Lagendijk, Cornelis A T Van den Berg, Rob H N Tijssen
Stereotactic body radiation therapy (SBRT) has shown great promise in increasing local control rates for renal-cell carcinoma (RCC). Characterized by steep dose gradients and high fraction doses, these hypo-fractionated treatments are, however, prone to dosimetric errors as a result of variations in intra-fraction respiratory-induced motion, such as drifts and amplitude alterations. This may lead to significant variations in the deposited dose. This study aims to develop a method for calculating the accumulated dose for MRI-guided SBRT of RCC in the presence of intra-fraction respiratory variations and determine the effect of such variations on the deposited dose...
August 3, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28766904/technical-note-trog-15-01-spark-trial-multi-institutional-imaging-dose-measurement
#16
Kimberley Legge, Peter B Greer, Paul J Keall, Jeremy T Booth, Sankar Arumugam, Trevor Moodie, Doan T Nguyen, Jarad Martin, Daryl John O'Connor, Joerg Lehmann
PURPOSE: The Trans-Tasman Radiation Oncology Group (TROG) 15.01 Stereotactic Prostate Adaptive Radiotherapy utilizing Kilovoltage intrafraction monitoring (SPARK) trial is a multicenter trial using Kilovoltage Intrafraction Monitoring (KIM) to monitor prostate position during the delivery of prostate radiation therapy. KIM increases the accuracy of prostate radiation therapy treatments and allows for hypofractionation. However, an additional imaging dose is delivered to the patient. A standardized procedure to determine the imaging dose per frame delivered using KIM was developed and applied at four radiation therapy centers on three different types of linear accelerator...
August 2, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28760507/use-of-a-second-dose-calculation-algorithm-to-check-dosimetric-parameters-for-the-dose-distribution-of-a-first-dose-calculation-algorithm-for-lung-sbrt-plans
#17
Yusuke Tsuruta, Mitsuhiro Nakamura, Yuki Miyabe, Manabu Nakata, Yoshitomo Ishihara, Nobutaka Mukumoto, Mami Akimoto, Tomohiro Ono, Shinsuke Yano, Kyoji Higashimura, Yukinori Matsuo, Takashi Mizowaki, Masahiro Hiraoka
PURPOSE: To verify lung stereotactic body radiotherapy (SBRT) plans using a secondary treatment planning system (TPS) as an independent method of verification and to define tolerance levels (TLs) in lung SBRT between the primary and secondary TPSs. METHODS: A total of 147 lung SBRT plans calculated using X-ray voxel Monte Carlo (XVMC) were exported from iPlan to Eclipse in DICOM format. Dose distributions were recalculated using the Acuros XB (AXB) and the anisotropic analytical algorithm (AAA), while maintaining monitor units (MUs) and the beam arrangement...
July 28, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28749375/towards-fast-online-intrafraction-replanning-for-free-breathing-stereotactic-body-radiation-therapy-with-the-mr-linac
#18
Charis Kontaxis, Gijsbert H Bol, Bjorn Stemkens, Markus Glitzner, Fieke M Prins, Linda G W Kerkmeijer, Jan J W Lagendijk, Bas W Raaymakers
The hybrid MRI-radiotherapy machines, like the MR-linac (Elekta AB, Stockholm, Sweden) installed at the UMC Utrecht (Utrecht, The Netherlands), will be able to provide real-time patient imaging during treatment. In order to take advantage of the system's capabilities and enable online adaptive treatments, a new generation of software should be developed, ranging from motion estimation to treatment plan adaptation. In this work we present a proof of principle adaptive pipeline designed for high precision Stereotactic Body Radiation Therapy (SBRT) suitable for sites affected by respiratory motion, like Renal Cell Carcinoma (RCC)...
July 27, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28749172/no-differences-in-radiological-changes-after-3d-conformal-vs-vmat-based-stereotactic-radiotherapy-for-early-stage-non-small-cell-lung-cancer
#19
Serena Badellino, Jacopo Di Muzio, Giulia Schivazappa, Alessia Guarneri, Riccardo Ragona, Sara Bartoncini, Elisabetta Trino, Andrea Riccardo Filippi, Paolo Fonio, Umberto Ricardi
OBJECTIVES: To compare patterns of acute and late radiological lung injury following either 3D or image-guided VMAT stereotactic radiotherapy for stage I Non-Small-Cell Lung Cancer (NSCLC). METHODS: We included 148 patients from a prospective mono-institutional SBRT series (time interval 2004-2014), treated with prescription BED10 Gy (at 80%) in the range 100-120 Gy. The first 95 patients (2004-2010) were planned with 3D-CRT, with a stereotactic body frame. The second cohort (2010-2014) included 53 patients, planned with volumetric IMRT on a smaller PTV generated from a patient's specific ITV, with a frameless approach through cone-beam CT guidance...
July 27, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28749165/impact-of-robotic-ultrasound-image-guidance-on-plan-quality-in-sbrt-of-the-prostate
#20
Stefan Gerlach, Ivo Kuhlemann, Floris Ernst, Christoph Fürweger, Alexander Schlaefer
OBJECTIVES: Ultrasound provides good image quality, fast volumetric imaging, and is established for abdominal image guidance. Robotic transducer placement may facilitate intra-fractional motion compensation in radiation therapy. We consider integration with the CyberKnife and study whether the kinematic redundancy of a seven-degrees-of-freedom robot allows for acceptable plan quality for prostate treatments. METHODS: Reference treatment plans were generated for ten prostate cancer cases previously treated with the CyberKnife...
July 27, 2017: British Journal of Radiology
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