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https://www.readbyqxmd.com/read/28197854/mitochondrial-complex-i-activity-is-conditioned-by-supercomplex-i-iii2-iv-assembly-in-brain-cells-relevance-for-parkinson-s-disease
#1
Irene Lopez-Fabuel, Monica Resch-Beusher, Monica Carabias-Carrasco, Angeles Almeida, Juan P Bolaños
The assembly of complex I (CI) with complexes III (CIII) and IV (CIV) of the mitochondrial respiratory chain (MRC) to configure I-III- or I-III-IV-containing supercomplexes (SCs) regulates mitochondrial energy efficiency and reactive oxygen species (mROS) production. However, whether the occurrence of SCs impacts on CI specific activity remains unknown to our knowledge. To investigate this issue, here we determined CI activity in primary neurons and astrocytes, cultured under identical antioxidants-free medium, from two mouse strains (C57Bl/6 and CBA) and Wistar rat, i...
February 14, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28193782/mitochondrial-mass-and-activity-as-a-function-of-body-composition-in-individuals-with-spinal-cord-injury
#2
Laura C O'Brien, Rodney C Wade, Liron Segal, Qun Chen, Jeannie Savas, Edward J Lesnefsky, Ashraf S Gorgey
Spinal cord injury (SCI) is accompanied by deterioration in body composition and severe muscle atrophy. These changes put individuals at risk for insulin resistance, type II diabetes, and cardiovascular disease. To determine the relationships between skeletal muscle mitochondrial mass, activity, and body composition, 22 men with motor complete SCI were studied. Body composition assessment was performed using dual-energy X-ray absorptiometry and magnetic resonance imaging. Skeletal muscle biopsies were obtained from the vastus lateralis muscle to measure citrate synthase (CS) and complex III (CIII) activity...
February 2017: Physiological Reports
https://www.readbyqxmd.com/read/28183059/copper-induced-metabolic-variation-of-oysters-overwhelmed-by-salinity-effects
#3
Chen Cao, Wen-Xiong Wang
In estuarine environments, Cu (copper) contamination is simultaneously coupled with salinity variation. In this study, (1)H NMR was applied to investigate the metabolic disturbance of estuarine oysters Crassostrea hongkongensis under both Cu and salinity stresses. Oysters were exposed to dissolved Cu (50 μg L(-1)) at different salinities (10, 15 and 25 psu) for six weeks, and the Cu accumulation in the oyster tissues was higher at lowered salinity. Based on the NMR-metabolomics results, disturbances induced by Cu and salinity was mainly related to osmotic regulation, energy metabolism and glycerophospholipid metabolism, as indicated by the alteration of important metabolic biomarkers such as alanine, citrate, glucose, glycogen, betaine, taurine, hypotaurine and homarine in the gills...
February 1, 2017: Chemosphere
https://www.readbyqxmd.com/read/28132645/5-aminolevulinic-acid-combined-with-ferrous-ion-reduces-adiposity-and-improves-glucose-tolerance-in-diet-induced-obese-mice-via-enhancing-mitochondrial-function
#4
Urara Ota, Takeshi Hara, Hitoshi Nakagawa, Emi Tsuru, Masayuki Tsuda, Atsuko Kamiya, Yasushi Kuroda, Yuya Kitajima, Aya Koda, Masahiro Ishizuka, Hideo Fukuhara, Keiji Inoue, Taro Shuin, Motowo Nakajima, Tohru Tanaka
BACKGROUND: Mitochondrial dysfunction is associated with obesity and various obesity-associated pathological conditions including glucose intolerance. 5-Aminolevulinic acid (ALA), a precursor of heme metabolites, is a natural amino acid synthesized in the mitochondria, and various types of cytochromes containing heme contribute to aerobic energy metabolism. Thus, ALA might have beneficial effects on the reduction of adiposity and improvement of glucose tolerance through its promotion of heme synthesis...
January 30, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28125052/serum-metabolomic-profiling-identifies-characterization-of-non-obstructive-azoospermic-men
#5
Zhe Zhang, Yingwei Zhang, Changjie Liu, Mingming Zhao, Yuzhuo Yang, Han Wu, Hongliang Zhang, Haocheng Lin, Lemin Zheng, Hui Jiang
Male infertility is considered a common health problem, and non-obstructive azoospermia with unclear pathogenesis is one of the most challenging tasks for clinicians. The objective of this study was to investigate the differential serum metabolic pattern in non-obstructive azoospermic men and to determine potential biomarkers related to spermatogenic dysfunction. Serum samples from patients with non-obstructive azoospermia (n = 22) and healthy controls (n = 31) were examined using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS)...
January 25, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28117969/bioinspired-cobalt-citrate-metal-organic-framework-as-an-efficient-electrocatalyst-for-water-oxidation
#6
Jing Jiang, Lan Huang, Xiaomin Liu, Lunhong Ai
Efficient and cost-effective oxygen evolution reaction (OER) electrocatalysts are closely associated with many important energy conversion technologies. Herein, we first report an oxygen-evolving cobalt-citrate metal-organic framework (MOF, UTSA-16) for highly efficient electrocatalytic water oxidation. Benefiting from synergistic cooperation of intrinsic open porous structure, in situ formed high valent cobalt species, and existing Co4O4 cubane, the UTSA-16 exhibits excellent activity toward OER catalysis in alkaline medium...
February 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28111353/gc-ms-based-metabolomics-identifies-an-amino-acid-signature-of-acute-ischemic-stroke
#7
Dian Wang, Jing Kong, Jiayan Wu, Xingxing Wang, Minchao Lai
Ischemic stroke is a serious public health problem worldwide. Here, we characterized the metabolite features of acute ischemic stroke (AIS) using a gas chromatography-mass spectrometry-based metabolomics. Forty AIS patients and 29 sex and age-matched controls were recruited. The serum metabolic profiles were significantly different between the two groups. Compared to the controls, the patients had elevated levels of lactate, carbonate and glutamate (P<0.01), and lowered levels of alanine, citrate, glycine, isoleucine, leucine, serine, tyrosine, methionine, tryptophan, erythronic acid, urea, purine, hypoxanthine, and proline in the serum (P<0...
January 19, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28109537/clinical-factors-associated-with-cerebral-metabolism-in-term-neonates-with-congenital-heart-disease
#8
Anna Lonyai Harbison, Jodie K Votava-Smith, Sylvia Del Castillo, S Ram Kumar, Vince Lee, Vincent Schmithorst, Hollie A Lai, Sharon O'Neil, Stefan Bluml, Lisa Paquette, Ashok Panigrahy
OBJECTIVE: To determine associations between patient and clinical factors with postnatal brain metabolism in term neonates with congenital heart disease (CHD) via the use of quantitative magnetic resonance spectroscopy. STUDY DESIGN: Neonates with CHD were enrolled prospectively to undergo pre- and postoperative 3T brain magnetic resonance imaging. Short-echo single-voxel magnetic resonance spectroscopy of parietal white matter was used to quantify metabolites related to brain maturation (n-acetyl aspartate, choline, myo- inositol), neurotransmitters (glutamate and gamma-aminobutyric acid), energy metabolism (glutamine, citrate, glucose, and phosphocreatine), and injury/apoptosis (lactate and lipids)...
January 19, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28107516/liver-amp-activated-protein-kinase-is-unnecessary-for-gluconeogenesis-but-protects-energy-state-during-nutrient-deprivation
#9
Clinton M Hasenour, D Emerson Ridley, Freyja D James, Curtis C Hughey, E Patrick Donahue, Benoit Viollet, Marc Foretz, Jamey D Young, David H Wasserman
AMPK is an energy sensor that protects cellular energy state by attenuating anabolic and promoting catabolic processes. AMPK signaling is purported to regulate hepatic gluconeogenesis and substrate oxidation; coordination of these processes is vital during nutrient deprivation or pathogenic during overnutrition. Here we directly test hepatic AMPK function in regulating metabolic fluxes that converge to produce glucose and energy in vivo. Flux analysis was applied in mice with a liver-specific deletion of AMPK (L-KO) or floxed control littermates to assess rates of hepatic glucose producing and citric acid cycle (CAC) fluxes...
2017: PloS One
https://www.readbyqxmd.com/read/28106122/comparative-genomics-and-transcriptome-analysis-of-aspergillus-niger-and-metabolic-engineering-for-citrate-production
#10
Xian Yin, Hyun-Dong Shin, Jianghua Li, Guocheng Du, Long Liu, Jian Chen
Despite a long and successful history of citrate production in Aspergillus niger, the molecular mechanism of citrate accumulation is only partially understood. In this study, we used comparative genomics and transcriptome analysis of citrate-producing strains-namely, A. niger H915-1 (citrate titer: 157 g L(-1)), A1 (117 g L(-1)), and L2 (76 g L(-1))-to gain a genome-wide view of the mechanism of citrate accumulation. Compared with A. niger A1 and L2, A. niger H915-1 contained 92 mutated genes, including a succinate-semialdehyde dehydrogenase in the γ-aminobutyric acid shunt pathway and an aconitase family protein involved in citrate synthesis...
January 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28096432/effects-of-activity-genetic-selection-and-their-interaction-on-muscle-metabolic-capacities-and-organ-masses-in-mice
#11
Scott A Kelly, Fernando R Gomes, Erik M Kolb, Jessica L Malisch, Theodore Garland
Chronic voluntary exercise elevates total daily energy expenditure (DEE) and food consumption, potentially resulting in organ compensation supporting nutrient extraction/utilization. Additionally, species with naturally higher DEE often have larger processing organs, which may represent genetic differences and/or phenotypic plasticity. We tested for possible adaptive changes in organ masses of 4 replicate lines of house mice selected (37 generations) for high running (HR lines) compared with 4 non-selected control (C) lines...
January 17, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28063249/effects-of-feeding-frequency-on-meat-quality-traits-and-longissimus-muscle-proteome-in-finishing-pigs
#12
J B Liu, X Cai, H Xiong, H F Zhang
Sixty-four barrows with an initial body weight of 59.8 ± 2.1 kg were allocated to one of the two feeding frequency regimes (had free access to diet and fed two meals per day). Pigs had free access (FA) to feed were fed on an ad libitum basis during the 8-week experimental period. Pigs fed twice daily (M2) were allowed to consume their meals in 2 h. Pigs fed twice daily had lower average daily feed intake (p < 0.01) and average daily gain (p < 0.1), but a greater G:F (p < 0.05) than FA pigs...
January 7, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28058526/citrate-a-ubiquitous-key-metabolite-with-regulatory-function-in-the-cns
#13
Niels Westergaard, Helle S Waagepetersen, Bo Belhage, Arne Schousboe
Citrate is key constituent of the tricarboxylic acid (TCA) cycle, serves as substrate for fatty acid and sterol biosynthesis, and functions as a key regulator of intermediary energy metabolism. Ursula Sonnewald had initiated studies using for the first time both proton- and (13)C-NMR to investigate metabolic processes in cultured neurons and astrocytes resulting in the important observation that citrate was specifically synthesized in and released from astrocytes in large amounts which is in keeping with the high concentration found in the CSF...
January 5, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28056169/concomitant-leaching-and-electrochemical-extraction-of-rare-earth-elements-from-monazite
#14
Synthia Maes, Wei-Qin Zhuang, Korneel Rabaey, Lisa Alvarez-Cohen, Tom Hennebel
Rare earth elements (REEs) have become increasingly important in modern day technologies. Unfortunately, their recycling is currently limited, and the conventional technologies for their extraction and purification are exceedingly energy and chemical intensive. New sustainable technologies for REE extraction from both primary and secondary resources would be extremely beneficial. This research investigated a two-stage recovery strategy focused on the recovery of neodymium (Nd) and lanthanum (La) from monazite ore that combines microbially based leaching (using citric acid and spent fungal supernatant) with electrochemical extraction...
January 18, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28055179/a-non-natural-protein-rescues-cells-deleted-for-a-key-enzyme-in-central-metabolism
#15
Katherine M Digianantonio, Maria Korolev, Michael H Hecht
An important goal of synthetic biology is to create novel proteins that provide life-sustaining functions in living organisms. Recent attempts to produce novel proteins have focused largely on rational design involving significant computational efforts. In contrast, nature does not design sequences a priori. Instead, nature relies on Darwinian evolution to select biologically functional sequences from nondesigned sequence space. To mimic natural selection in the laboratory, we combed through libraries of novel sequences and selected proteins that rescue E...
January 19, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28051856/enhanced-cellular-internalization-a-bactericidal-mechanism-more-relative-to-biogenic-nanoparticles-than-chemical-counterparts
#16
Madhuree Kumari, Shatrunajay Shukla, Shipra Pandey, Ved P Giri, Anil Bhatia, Tusha Tripathi, Poonam Kakkar, Chandra S Nautiyal, Aradhana Mishra
Biogenic synthesis of silver nanoparticles for enhanced antimicrobial activity has gained a lot of momentum making it an urgent need to search for a suitable biocandidate which could be utilized for efficient capping and shaping of silver nanoparticles with enhanced bactericidal activity utilizing its secondary metabolites. Current work illustrates the enhancement of antimicrobial efficacy of silver nanoparticles by reducing and modifying their surface with antimicrobial metabolites of cell free filtrate of Trichoderma viride (MTCC 5661) in comparison to citrate stabilized silver nanoparticles...
January 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28041819/circulating-tricarboxylic-acid-cycle-metabolite-levels-in-citrin-deficient-children-with-metabolic-adaptation-with-and-without-sodium-pyruvate-treatment
#17
Hironori Nagasaka, Haruki Komatsu, Ayano Inui, Mariko Nakacho, Ichiro Morioka, Hirokazu Tsukahara, Shunsaku Kaji, Satoshi Hirayama, Takashi Miida, Hiroki Kondou, Kenji Ihara, Mariko Yagi, Zenro Kizaki, Kazuhiko Bessho, Takahiro Kodama, Kazumoto Iijima, Takeyori Saheki, Tohru Yorifuji, Akira Honda
Citrin deficiency causes adult-onset type II citrullinemia (CTLN-2), which later manifests as severe liver steatosis and life-threatening encephalopathy. Long-standing energy deficit of the liver and brain may predispose ones to CTLN-2. Here, we compared the energy-driving tricarboxylic acid (TCA) cycle and fatty acid β-oxidation cycle between 22 citrin-deficient children (age, 3-13years) with normal liver functions and 37 healthy controls (age, 5-13years). TCA cycle analysis showed that basal plasma citrate and α-ketoglutarate levels were significantly higher in the affected than the control group (p<0...
December 24, 2016: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/27987392/urinary-metabolic-profiling-of-cisplatin-nephrotoxicity-and-nephroprotective-effects-of-orthosiphon-stamineus-leaves-elucidated-by-1-h-nmr-spectroscopy
#18
Raghunath Pariyani, Intan Safinar Ismail, Amalina Azam, Alfi Khatib, Faridah Abas, Khozirah Shaari, Hazilawati Hamza
Orthosiphon stamineus (OS) is a popular medicinal herb used in traditional Chinese medicine as a diuretic agent and for renal system disorders. This study employed (1)H NMR based metabolomics approach to investigate the possible protective activity of OS in cisplatin induced nephrotoxicity owing to its diuretic and antioxidant activities. Aqueous (OSAE) and 50% aqueous ethanolic (OSFE) extracts of OS leaves were orally administered at 400mg/kg BW doses to rats which were then intraperitoneally injected with cisplatin at 5mg/kg BW dose...
December 8, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27977114/in-situ-activated-n-doped-mesoporous-carbon-from-a-protic-salt-and-its-performance-in-supercapacitors
#19
Tiago C Mendes, Changlong Xiao, Fengling Zhou, Haitao Li, Gregory P Knowles, Matthias Hilder, Anthony Somers, Patrick C Howlett, Douglas R MacFarlane
Protic salts have been recently recognized to be an excellent carbon source to obtain highly ordered N-doped carbon without the need of tedious and time-consuming preparation steps that are usually involved in traditional polymer-based precursors. Herein, we report a direct co-pyrolysis of an easily synthesized protic salt (benzimidazolium triflate) with calcium and sodium citrate at 850 °C to obtain N-doped mesoporous carbons from a single calcination procedure. It was found that sodium citrate plays a role in the final carbon porosity and acts as an in situ activator...
December 28, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27976867/uniform-fe3o4-nitrogen-doped-mesoporous-carbon-spheres-derived-from-ferric-citrate-bonded-melamine-resin-as-an-efficient-synergistic-catalyst-for-oxygen-reduction
#20
Haitao Wang, Wei Wang, Mengxi Gui, Muhammad Asif, Zhengyun Wang, Yang Yu, Junwu Xiao, Hongfang Liu
Developing a facile strategy to synthesize an efficient and inexpensive catalyst for the oxygen reduction reaction (ORR) is critical to the commercialization of many sustainable energy storage and conversion techniques. Herein, a novel and convenient strategy was presented to prepare Fe3O4 embedded into nitrogen-doped mesoporous carbon spheres (Fe3O4/N-MCS) by the polycondensation between methylolmelamines and ammonium ferric citrate (AFC) and subsequent pyrolysis process. In particular, the polycondensation reaction was completely finished within a very short time (6...
December 23, 2016: ACS Applied Materials & Interfaces
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