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https://www.readbyqxmd.com/read/28934963/metabolic-status-of-csf-distinguishes-rats-with-tauopathy-from-controls
#1
Radana Karlíková, Kateřina Mičová, Lukáš Najdekr, Alžběta Gardlo, Tomáš Adam, Petra Majerová, David Friedecký, Andrej Kováč
BACKGROUND: Tauopathies represent heterogeneous groups of neurodegenerative diseases that are characterised by abnormal deposition of the microtubule-associated protein tau. Alzheimer's disease is the most prevalent tauopathy, affecting more than 35 million people worldwide. In this study we investigated changes in metabolic pathways associated with tau-induced neurodegeneration. METHODS: Cerebrospinal fluid (CSF), plasma and brain tissue were collected from a transgenic rat model for tauopathies and from age-matched control animals...
September 21, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/28931857/eu-3-activated-la2moo6-la2wo6-red-emitting-phosphors-with-ultrabroad-excitation-band-for-white-light-emitting-diodes
#2
Peng Du, Jae Su Yu
A series of novel Eu(3+)-activated La2MoO6-La2WO6 red-emitting phosphors have been successfully prepared by a citrate-assisted sol-gel process. Both photoluminescence excitation and emission spectra suggest that the resultant products have the strong ultrabroad absorption band ranging from 220 to 450 nm. Under the excitation of 379 nm, the characteristic emissions of Eu(3+) ions corresponding to the (5)D0 → (7)F J transitions are observed in the doped samples. The optimal doping concentration for Eu(3+) ions is found to be 12 mol% and the quenching mechanism is attributed to the dipole-dipole interaction...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28928660/-1-h-nmr-based-metabolomics-study-of-the-toxicological-effects-in-rats-induced-by-renqing-mangjue-pill-a-traditional-tibetan-medicine
#3
Can Xu, Caidan Rezeng, Jian Li, Lan Zhang, Yujing Yan, Jian Gao, Yingfeng Wang, Zhongfeng Li, Jianxin Chen
"RenqingMangjue" pill (RMP), as an effective prescription of Traditional Tibetan Medicine (TTM), has been widely used in treating digestive diseases and ulcerative colitis for over a thousand years. In certain classical Tibetan Medicine, heavy metal may add as an active ingredient, but it may cause contamination unintentionally in some cases. Therefore, the toxicity and adverse effects of TTM became to draw public attention. In this study, 48 male Wistar rats were orally administrated with different dosages of RMP once a day for 15 consecutive days, then half of the rats were euthanized on the 15th day and the remaining were euthanized on the 30th day...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28928294/factors-affecting-reduction-of-reference-endotoxin-standard-activity-caused-by-chelating-agent-detergent-matrices-kinetic-analysis-of-low-endotoxin-recovery
#4
Masakazu Tsuchiya
Reduction of reference standard endotoxin (RSE) activity was kinetically analyzed under low endotoxin recovery (LER) conditions, and was considered as an apparent first-order reaction. Temperature, pH, and salt concentrations affected the rates of reduction of RSE activity. Temperature appeared to be the most important factor affecting LER. Components of LER matrices, such as citrate and polysorbate 20 showed similar LER effect at concentrations commonly used. Phosphate concentrations showed negative correlation against the half-life of RSE activity in solutions containing phosphate buffer and polysorbate 20...
September 19, 2017: PDA Journal of Pharmaceutical Science and Technology
https://www.readbyqxmd.com/read/28919865/coping-with-salt-water-habitats-metabolic-and-oxidative-responses-to-salt-intake-in-the-rufous-collared-sparrow
#5
Pablo Sabat, Cristóbal Narváez, Isaac Peña-Villalobos, Carolina Contreras, Karin Maldonado, Juan C Sanchez-Hernandez, Seth D Newsome, Roberto Nespolo, Francisco Bozinovic
Many physiological adjustments occur in response to salt intake in several marine taxa, which manifest at different scales from changes in the concentration of individual molecules to physical traits of whole organisms. Little is known about the influence of salinity on the distribution, physiological performance, and ecology of passerines; specifically, the impact of drinking water salinity on the oxidative status of birds has been largely ignored. In this study, we evaluated whether experimental variations in the salt intake of a widely-distributed passerine (Zontotrichia capensis) could generate differences in basal (BMR) and maximum metabolic rates (Msum), as well as affect metabolic enzyme activity and oxidative status...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28914810/an-nmr-based-metabolomic-approach-to-unravel-the-preventive-effect-of-water-soluble-extract-from-dendrobium-officinale-kimura-migo-on-streptozotocin-induced-diabetes-in-mice
#6
Hong Zheng, Linlin Pan, Pengtao Xu, Jianjun Zhu, Ruohan Wang, Wenzong Zhu, Yongsheng Hu, Hongchang Gao
Dendrobium officinale Kimura & Migo (D. officinale) is a precious herbal medicine. In this study, we investigated metabolic mechanism underlying the effect of D. officinale water extract (DOWE) on diabetes prevention in mice after streptozotocin (STZ) exposure using NMR-based metabolomics. Interestingly, we found a decrease in blood glucose and an increase in liver glycogen in mice pretreated with DOWE after STZ exposure. The DOWE pretreatment significantly increased citrate and glutamine in the serum as well as creatine, alanine, leucine, isoleucine, valine, glutamine, glutathione and taurine in the liver of STZ-treated mice...
September 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28905141/insights-into-the-simultaneous-utilization-of-glucose-and-glycerol-by-streptomyces-albulus-m-z18-for-high-%C3%AE%C2%B5-poly-l-lysine-productivity
#7
Xin Zeng, Junjie Zhao, Xusheng Chen, Zhonggui Mao, Wenyun Miao
The simultaneous consumption of glucose and glycerol led to remarkably higher productivity of both biomass and ε-poly-L-lysine (ε-PL), which was of great significance in industrial microbial fermentation. To further understand the superior fermentation performances, transcriptional analysis and exogenous substrates addition were carried out to study the simultaneous utilization of glucose and glycerol by Streptomyces albulus M-Z18. Transcriptome analysis revealed that there was no mutual transcriptional suppression between the utilization of glucose and glycerol, which was quite different from typical "glucose effect"...
September 13, 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/28866167/design-of-multi-functional-cotton-gauze-with-antimicrobial-and-drug-delivery-properties
#8
Mohamed Rehan, S Zaghloul, F A Mahmoud, A S Montaser, A Hebeish
The ideal biomedical fiber/fabric materials can both promote the drug delivery properties and prevent microbial infection. Herein we present an innovation-based strategy for fabrication of biomedical cotton gauze which concomitantly displays antimicrobial and drug delivery performance properties. The innovative strategy involved three distinct steps: (1) Cationization of cotton gauze by reacting it with 3-chloro-2-hydroxypropyl trimethyl ammonium chloride [Quat-188] or anionization of cotton gauze through partial carboxymethylation...
November 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28860003/sleep-restriction-induced-energy-methylation-and-lipogenesis-metabolic-switches-in-rat-liver
#9
Arjun Sengupta, Seth D Rhoades, Eun Ji Kim, Soumyashant Nayak, Gregory R Grant, Peter Meerlo, Aalim M Weljie
Sleep curtailment is ubiquitous in modern day society. Sleep debt is associated with maladaptive physiological changes that can lead to cardiometabolic and neuropsychiatric pathologies. Recent literature has shown the effects of sleep restriction (SR) on systemic metabolic profiles in biofluids, implying that tissue-specific metabolomes are impacted by SR. To test this hypothesis, we assessed hepatic metabolic profiles of rats after 5days of SR using UPLC-MS based metabolomics analysis and gene expression analysis...
August 28, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28855713/deciphering-clostridium-metabolism-and-its-responses-to-bioreactor-mass-transfer-during-syngas-fermentation
#10
Ni Wan, Ashik Sathish, Le You, Yinjie J Tang, Zhiyou Wen
This study used (13)C tracers and dynamic labeling to reveal metabolic features (nutrients requirements, pathway delineation and metabolite turnover rates) of Clostridium carboxidivorans P7, a model strain for industrial syngas fermentation, and its implication with bioreactor mass transfer. P7 shows poor activity for synthesizing amino acids (e.g., phenylalanine) and thus, needs rich medium for cell growth. The strain has multiple carbon fixation routes (Wood-Ljungdahl pathway, pyruvate:ferredoxin oxidoreductase reaction and anaplerotic pathways) and Re-citrate synthase (Ccar_06155) was a key enzyme in its tricarboxylic acid cycle (TCA) pathway...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28822951/effect-of-deflocculation-on-photo-induced-thin-layer-titanium-dioxide-disintegration-of-dairy-waste-activated-sludge-for-cost-and-energy-efficient-methane-production
#11
V Godvin Sharmila, P Dhanalakshmi, J Rajesh Banu, S Kavitha, M Gunasekaran
In the present study, the deflocculated sludge was disintegrated through thin layer immobilized titanium dioxide (TiO2) as photocatalyst under solar irradiation. The deflocculation of sludge was carried out by 0.05g/g SS of sodium citrate aiming to facilitate more surface area for subsequent TiO2 mediated disintegration. The proposed mode of disintegration was investigated by varying TiO2 dosage, pH and time. The maximum COD solubilization of 18.4% was obtained in the optimum 0.4g/L of TiO2 dosage with 5.5 pH and exposure time of 40min...
November 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28821606/flipping-a-citrate-switch-on-liver-cancer-cells
#12
REVIEW
Jeffrey M Peters
Energy homeostasis and oncogenic signaling are critical determinants of the growth of human liver cancer cells, providing a strong rationale to elucidate the regulatory mechanisms for these systems. A new study reports that loss of solute carrier family 13 member 5, which transports citrate across cell membranes, halts liver cancer cell growth by altering both energy production and mammalian target of rapamycin signaling in human liver cancer cell lines and in both an in vitro and in vivo model of liver tumors, suggesting a new target for liver cancer chemoprevention and/or chemotherapy...
August 18, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28798690/risk-of-myopathy-in-patients-in-therapy-with-statins-identification-of-biological-markers-in-a-pilot-study
#13
Giulia M Camerino, Olimpia Musumeci, Elena Conte, Kejla Musaraj, Adriano Fonzino, Emanuele Barca, Marco Marino, Carmelo Rodolico, Domenico Tricarico, Claudia Camerino, Maria R Carratù, Jean-François Desaphy, Annamaria De Luca, Antonio Toscano, Sabata Pierno
Statin therapy may induce skeletal muscle damage ranging from myalgia to severe rhabdomyolysis. Our previous preclinical studies showed that statin treatment in rats involves the reduction of skeletal muscle ClC-1 chloride channel expression and related chloride conductance (gCl). An increase of the activity of protein kinase C theta (PKC theta) isoform, able to inactivate ClC-1, may contribute to destabilize sarcolemma excitability. These effects can be detrimental for muscle function leading to drug-induced myopathy...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28795710/quantification-of-nucleobases-gold-nanoparticles-interactions-energetics-of-the-interactions-through-apparent-binding-constants-determination
#14
J M Carnerero, A Sánchez-Coronilla, E I Martín, A Jimenez-Ruiz, R Prado-Gotor
We explore the possibilities of quantifying the interaction of both adenine and thymine with non-functionalized, anionic citrate gold nanoparticles (AuNPs). Following the plasmon absorbance band's red shifts, dependent of the AuNPs aggregation state, apparent binding free energies of the system are obtained for the sum of the two processes (nucleobase interaction plus nanoparticle aggregation). A deconvolution procedure confirms those results. Those apparent binding free energies are, in both cases, in good agreement with previous studies indicating an increased reactivity for adenine...
August 23, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28759723/physiological-and-transcriptomic-analysis-validates-previous-findings-of-changes-in-primary-metabolism-for-the-production-of-phenolic-antioxidants-in-wounded-carrots
#15
Cong Han, Peng Jin, Meilin Li, Lei Wang, Yonghua Zheng
Wounding induces the accumulation of phenolic compounds in carrot. This study uses physiological and transcriptomic analysis to validate previous findings relating primary metabolism and secondary metabolites in wounded carrots. Our data confirmed that increased wounding intensity strengthened the accumulation of phenolics accompanied by enhancing respiration and showed the loss of fructose and glucose and the increase of energy status in carrots. In addition, transcriptomic evaluation of shredded carrots indicated that the respiratory metabolism, sugar metabolism, energy metabolism, and phenolic biosynthesis related pathways, such as "citrate cycle (TCA cycle)", "oxidative phosphorylation" and "phenylpropanoid biosynthesis", were activated by wounding...
August 23, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28746356/metabolomic-profiling-of-csf-in-multiple-sclerosis-and-neuromyelitis-optica-spectrum-disorder-by-nuclear-magnetic-resonance
#16
Hyun-Hwi Kim, In Hye Jeong, Ja-Shil Hyun, Byung Soo Kong, Ho Jin Kim, Sung Jean Park
Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are inflammatory diseases of the central nervous system. Although several studies have characterized the metabolome in the cerebrospinal fluid (CSF) from MS and NMOSD patients, comparative analyses between them and between the relapse and the remission of each disease have not been performed. Both univariate and multivariate analyses were used to compare 1H-NMR spectra of CSF from MS, NMOSD, and healthy controls (HCs). The statistical analysis showed alterations of eight metabolites that were dependent on the disease...
2017: PloS One
https://www.readbyqxmd.com/read/28726671/in-situ-decoration-of-plasmonic-au-nanoparticles-on-graphene-quantum-dots-graphitic-carbon-nitride-hybrid-and-evaluation-of-its-visible-light-photocatalytic-performance
#17
Gone Rajender, Biswajit Choudhury, P K Giri
This work spotlights the development of a plasmonic photocatalyst showing surface plasmon induced enhanced visible light photocatalytic (PC) performance. Plasmonic Au nanoparticles (NPs) are decorated over the hybrid nanosystem of graphitic carbon nitride (GCN) and graphene quantum dots (GQD) by citrate reduction method. Surface plasmon resonance (SPR) induced enhancement of Raman G and 2D band intensity is encountered on excitation of the Plasmonic hybrid at 514.5 nm, which is near to the 532 nm absorption band of Au NPs...
July 20, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28704856/effects-of-highly-pure-enriched-cellulose-diet-on-digestibility-lipid-metabolism-and-redox-status-in-obese-offspring-of-streptozotocin-induced-diabetic-rats
#18
Bensalah Meryem, Bouanane Samira, Benyagoub Ouahiba, Merzouk Hafida, Baba Ahmed Fatima Zohra
The long-term nutritional efficacy of a highly-pure-enriched-cellulose (HPEC) diet and its effects on lipid metabolism and oxidant/antioxidant status were investigated in obese offspring of streptozotocin-induced diabetic rats. Diabetes in pregnant rats was induced by intraperitoneal injection of streptozotocin on day 5 of gestation. Control pregnant rats were injected with citrate buffer. At weaning offspring of diabetic and control rats were fed HPEC or control diet, they were housed individually in metabolic cage for 2 months to investigate the nutritional efficacy of the diets...
July 13, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28697307/prawn-shell-derived-chitin-nanofiber-membranes-as-advanced-sustainable-separators-for-li-na-ion-batteries
#19
Tian-Wen Zhang, Bao Shen, Hong-Bin Yao, Tao Ma, Lei-Lei Lu, Fei Zhou, Shu-Hong Yu
Separators, necessary components to isolate cathodes and anodes in Li/Na-ion batteries, are consumed in large amounts per year; thus, their sustainability is a concerning issue for renewable energy storage systems. However, the eco-efficient and environmentally friendly fabrication of separators with a high mechanical strength, excellent thermal stability, and good electrolyte wettability is still challenging. Herein, we reported the fabrication of a new type of separators for Li/Na-ion batteries through the self-assembly of eco-friendly chitin nanofibers derived from prawn shells...
July 13, 2017: Nano Letters
https://www.readbyqxmd.com/read/28682939/burn-trauma-acutely-increases-the-respiratory-capacity-and-function-of-liver-mitochondria
#20
Fredrick J Bohanon, Omar Nunez Lopez, David N Herndon, Xiaofu Wang, Nisha Bhattarai, Amina El Ayadi, Anesh Prasai, Jayson W Jay, Yesenia Rojas-Khalil, Tracy E Toliver-Kinsky, Celeste C Finnerty, Ravi S Radhakrishnan, Craig Porter
BACKGROUND: A complete understanding of the role of the liver in burn-induced hypermetabolism is lacking. We investigated the acute effect of severe burn trauma on liver mitochondrial respiratory capacity and coupling control as well as the signaling events underlying these alterations. METHODS: Male BALB/c mice (8-12 weeks) received full-thickness scald burns on ∼30% of the body surface. Liver tissue was harvested 24 hours post injury. Mitochondrial respiration was determined by high-resolution respirometry...
July 4, 2017: Shock
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