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https://www.readbyqxmd.com/read/29788892/inhibition-of-glycolysis-and-glutaminolysis-emerging-drug-discovery-approach-to-combat-cancer
#1
Nicholas S Akins, Tanner C Nielson, Hoang V Le
Cancer cells have a very different metabolism from that of normal cells from which they are derived. Their metabolism is elevated, which allows them to sustain higher proliferative rate and resist some cell death signals. This phenomenon, known as the "Warburg effect", has become the focus of intensive efforts in the discovery of new therapeutic targets and new cancer drugs. Both glycolysis and glutaminolysis pathways are enhanced in cancer cells. While glycolysis is enhanced to satisfy the increasing energy demand of cancer cells, glutaminolysis is enhanced to provide biosynthetic precursors for cancer cells...
May 22, 2018: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29778145/impact-of-density-of-coating-agent-on-antibacterial-activity-of-silver-nanoparticle-impregnated-plasma-treated-activated-carbon
#2
Pritam Biswas, Rajdip Bandyopadhyaya
To use stabilized nanoparticles (NPs) in water as disinfectants over a very long period, the amount of coating agent (for NP stabilization) needs to be optimized. To this end, silver nanoparticles (Ag-NPs) with two different coating densities of tri-sodium citrate (12.05 and 46.17molecules/nm2 , respectively), yet of very similar particle size (29 and 27 nm, respectively) were synthesized. Both sets of citrate capped NPs were then separately impregnated on plasma treated activated carbon (AC), with similar Ag loading of 0...
May 2018: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/29775926/chlorophyll-a-%C3%AF-uorescence-and-transcriptome-reveal-the-toxicological-effects-of-bisphenol-a-on-an-invasive-cyanobacterium-cylindrospermopsis-raciborskii
#3
Rong Xiang, Junqiong Shi, Hongbo Zhang, Congcong Dong, Li Liu, JunKe Fu, Xinyu He, Yanjun Yan, Zhongxing Wu
Bisphenol A has attracted worldwide attention due to its harmful effects on humans, animals and plants. In this study, the toxicological effects of BPA on Cylindrospermopsis raciborskii were assessed based on chlorophyll a fluorescence and transcriptome analyses. The results showed that the growth of C. raciborskii was significantly inhibited when BPA exceeded 0.1 mg L-1 . A marked rise of phase J was observed at a concentration greater than 0.1 mg L-1 , while a K phase appeared at 20 mg L-1 . The chlorophyll a fluorescence parameters of RC/CS0 , F0 , φP0 , φE0 , and ψ0 , underwent a significant decline under all treatments of BPA, whereas a significant increase in both VJ and M0 occurred under all concentrations of BPA...
May 9, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29751601/novel-sustainable-composites-based-on-poly-hydroxybutyrate-co-hydroxyvalerate-and-seagrass-beach-cast-fibers-performance-and-degradability-in-marine-environments
#4
Maurizia Seggiani, Patrizia Cinelli, Elena Balestri, Norma Mallegni, Eleonora Stefanelli, Alessia Rossi, Claudio Lardicci, Andrea Lazzeri
In order to produce sustainable, bio-based and highly biodegradable materials, composites based on poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) and fibers of Posidonia oceanica (PO), a dominant Mediterranean seagrass, were produced by simple melt mixing and characterized in terms of thermal stability, morphology and rheological/mechanical properties. In view of their potential application in marine environments, degradation of the developed composites was evaluated under simulated and real marine environmental conditions for 1 year...
May 11, 2018: Materials
https://www.readbyqxmd.com/read/29748131/underlying-mechanism-of-the-contractile-dysfunction-in-atrophied-ventricular-myocytes-from-a-murine-model-of-hypothyroidism
#5
Dolores Montalvo, Perla Pérez-Treviño, Katheryne Madrazo-Aguirre, Fabio A González-Mondellini, Hipólito O Miranda-Roblero, Diego Ramonfaur-Gracia, Mariana Jacobo-Antonio, Maritza Mayorga-Luna, Norma L Gómez-Víquez, Noemí García, Julio Altamirano
Hypothyroidism (Hypo) is a risk factor for cardiovascular diseases, including heart failure. Hypo rapidly induces Ca2+ mishandling and contractile dysfunction (CD), as well as atrophy and ventricular myocytes (VM) remodeling. Hypo decreases SERCA-to-phospholamban ratio (SERCA/PLB), and thereby contributes to CD. Nevertheless, detailed spatial and temporal Ca2+ cycling characterization in VM is missing, and contribution of other structural and functional changes to the mechanism underlying Ca2+ mishandling and CD, as transverse tubules (T-T) remodeling, mitochondrial density (Dmit ) and energy availability, is unclear...
February 5, 2018: Cell Calcium
https://www.readbyqxmd.com/read/29738098/a-4-v-li-ion-battery-using-all-spinel-based-electrodes
#6
Mobinul Islam, Min-Gi Jeong, Ghulam Ali, In-Hwan Oh, Kyung Yoon Chung, Yang-Kook Sun, Hun-Gi Jung
Boosting the performance of rechargeable Li-ion batteries beyond the state-of-the-art is mandatory toward meeting the future energy requirements of the consumer mass market. The replacement of conventional graphite anodes by conversion-type metal-oxide anodes is one progressive approach toward achieving this goal. Here, a lithium-ion battery consisting of a high-capacity spinel NiMn2O4 anode and a high-voltage spinel LiNi0.5Mn1.5O4 cathode was proposed. Polyhedral-shaped NiMn2O4 powder was prepared from a citrate precursor via the sol-gel method...
May 8, 2018: ChemSusChem
https://www.readbyqxmd.com/read/29722617/cheap-labor-myosin-fiber-type-expression-and-enzyme-activity-in-the-forelimb-musculature-of-sloths-pilosa-xenarthra
#7
Kyle B Spainhower, Rebecca N Cliffe, Allan K Metz, Ernest M Barkett, Paije M Kiraly, Dylan R Thomas, Sarah J Kennedy, Judy Avey-Arroyo, Michael T Butcher
Sloths are canopy-dwelling inhabitants of American neotropical rainforests that exhibit suspensory behaviors. These abilities require both strength and muscular endurance to hang for extended periods of time; however, the skeletal muscle mass of sloths is reduced, thus requiring modifications to muscle architecture and leverage for large joint torque. We hypothesize that intrinsic muscle properties also are modified for fatigue resistance and predict a heterogeneous expression of slow/fast myosin heavy chain (MHC) fibers that utilize oxidative metabolic pathways for economic force production...
May 3, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29721422/runx2-osterix-and-zinc-uptake-synergize-to-orchestrate-osteogenic-differentiation-and-citrate-containing-bone-apatite-formation
#8
Xuekun Fu, Yunyan Li, Tongling Huang, Zhiwu Yu, Kun Ma, Meng Yang, Qingli Liu, Haobo Pan, Huaiyu Wang, Junfeng Wang, Min Guan
Citrate is essential to biomineralization of the bone especially as an integral part of apatite nanocomposite. Citrate precipitate of apatite is hypothesized to be derived from mesenchymal stem/stromal cells (MSCs) upon differentiation into mature osteoblasts. Based on 13 C-labeled signals identified by solid-state multinuclear magnetic resonance analysis, boosted mitochondrial activity and carbon-source replenishment of tricarboxylic acid cycle intermediates coordinate to feed forward mitochondrial anabolism and deposition of citrate...
April 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/29721175/the-decrease-of-glycolytic-enzyme-hexokinase-1-accelerates-tumor-malignancy-via-deregulating-energy-metabolism-but-sensitizes-cancer-cells-to-2-deoxyglucose-inhibition
#9
Po-Lin Tseng, Chih-Wei Chen, Keng-Hsun Hu, Hung-Chi Cheng, Yuan-Ho Lin, Wen-Hui Tsai, Tain-Junn Cheng, Wei-Hsuan Wu, Chin-Wei Yeh, Chin-Chih Lin, Hui-Ju Tsai, Hao-Chun Chang, Jiin-Haur Chuang, Yan-Shen Shan, Wen-Tsan Chang
Malignant tumors often display an aberrant energy metabolism that relies primarily on glycolysis to produce adenosine triphosphate (ATP) the so-called Warburg effect or aerobic glycolysis. Thus, the elucidation of this energetic alteration in malignant tumors is important in the search for more effective therapeutics against malignant cancers, the most deadly human disease. To investigate whether attenuated glycolytic activity modulates tumor progression, the effects of silencing the first and rate-limiting glycolytic enzyme hexokinase (HK) isozymes HK1 and HK2 were examined...
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29713165/sensitive-determination-of-dopamine-levels-via-surface-enhanced-raman-scattering-of-ag-nanoparticle-dimers
#10
Xiantong Yu, XiaoXiao He, Taiqun Yang, Litao Zhao, Qichen Chen, Sanjun Zhang, Jinquan Chen, Jianhua Xu
Background: Dopamine (DA) is an important neurotransmitter in the hypothalamus and pituitary gland, which can produce a direct influence on mammals' emotions in midbrain. Additionally, the level of DA is highly related with some important neurologic diseases such as schizophrenia, Parkinson, and Huntington's diseases, etc. In light of the important roles that DA plays in the disease modulation, it is of considerable significance to develop a sensitive and reproducible approach for monitoring DA...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29691027/ultra-fast-and-highly-efficient-removal-of-cadmium-ions-by-magnetic-layered-double-hydroxide-guargum-bionanocomposites
#11
Mohammad Dinari, Reyhane Tabatabaeian
Finding effective methodologies for the removal of heavy metals from contaminated water are really significant. Facile and "green" techniques for adsorbents fabrication are in high demand to satisfy a wide range of practical applications. This report presents of an efficient method for preparing Fe3 O4 @ layered double hydroxide@ guargum bionanocomposites (GLF-BNCs). First of all, the LDH coated Fe3 O4 nanoparticles were simply synthesized, using ultrasonic irradiation. The citrate coated Fe3 O4 nanoparticles which were under negative charging and LDH nanocrystals which were charged positively make electrostatic interaction which formed a stable self-assembly component, and then guargum as a biopolymer were linked onto Fe3 O4 @LDH via an in situ growth method...
July 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29680869/metabolic-analyses-of-the-improved-%C3%AE%C2%B5-poly-l-lysine-productivity-using-a-glucose-glycerol-mixed-carbon-source-in-chemostat-cultures
#12
Jian-Hua Zhang, Xin Zeng, Xu-Sheng Chen, Zhong-Gui Mao
The glucose-glycerol mixed carbon source remarkably reduced the batch fermentation time of ε-poly-L-lysine (ε-PL) production, leading to higher productivity of both biomass and ε-PL, which was of great significance in industrial microbial fermentation. Our previous study confirmed the positive influence of fast cell growth on the ε-PL biosynthesis, while the direct influence of mixed carbon source on ε-PL production was still unknown. In this work, chemostat culture was employed to study the capacity of ε-PL biosynthesis in different carbon sources at a same dilution rate of 0...
April 21, 2018: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/29677795/facile-synthesis-of-efficient-antibacterial-agent-as-cofe%C3%A2-o%C3%A2-ag-composite-material-against-both-gram-negative-escherichia-coli-and-gram-positive-bacillus-subtilis-bacteria
#13
Sukhbayar Gankhuyag, Kyoung Lee, Dong Sik Bae
We have suggested that a facile synthesis of CoFe2O4/Ag composite material as an antibacterial agent for substitution of a chlorination agent for microbial infected wastewater treatment. The CoFe2O4/Ag was synthesized by an impregnation method in assistance with trisodium citrate as a reducing agent. The as-prepared uncalcined CoFe2O4 (CFG), calcined CoFe2O4 (CFG600), and calcined CoFe2O4/Ag (CFG600/Ag) composites were characterized by X-ray diffraction (XRD), Field Emission Scanning Electron Microscope (FE-SEM) and Energy Dispersive X-ray (EDX) techniques...
September 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29675013/development-of-chemically-defined-media-reveals-citrate-as-preferred-carbon-source-for-liberibacter-growth
#14
Maritsa Cruz-Munoz, Joseph R Petrone, Alexa R Cohn, Alam Munoz-Beristain, Nabil Killiny, Jennifer C Drew, Eric W Triplett
Liberibacter crescens is the closest cultured relative of four important uncultured crop pathogens. Candidatus L. asiaticus, L. americanus, and L. africanus are causal agents of citrus greening disease, otherwise known as huanglongling (HLB). Candidatus L. solanacearum is responsible for potato Zebra chip disease. Cultures of L. crescens grow slowly on BM-7 complex medium, while attempts to culture the Ca. Liberibacter pathogens in BM-7 have failed. Developing a defined medium for the growth of L. crescens will be useful in the study of Liberibacter metabolism and will improve the prospects for culturing the Ca ...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29651165/the-mitochondrial-citrate-carrier-slc25a1-drives-stemness-and-therapy-resistance-in-non-small-cell-lung-cancer
#15
Harvey R Fernandez, Shreyas M Gadre, Mingjun Tan, Garrett T Graham, Rami Mosaoa, Martin S Ongkeko, Kyu Ah Kim, Rebecca B Riggins, Erika Parasido, Iacopo Petrini, Simone Pacini, Amrita Cheema, Rency Varghese, Habtom W Ressom, Yuwen Zhang, Christopher Albanese, Aykut Üren, Mikell Paige, Giuseppe Giaccone, Maria Laura Avantaggiati
Therapy resistance represents a clinical challenge for advanced non-small cell lung cancer (NSCLC), which still remains an incurable disease. There is growing evidence that cancer-initiating or cancer stem cells (CSCs) provide a reservoir of slow-growing dormant populations of cells with tumor-initiating and unlimited self-renewal ability that are left behind by conventional therapies reigniting post-therapy relapse and metastatic dissemination. The metabolic pathways required for the expansion of CSCs are incompletely defined, but their understanding will likely open new therapeutic opportunities...
April 12, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29616997/crystal-structures-of-alkali-metal-group-1-citrate-salts
#16
Alagappa Rammohan, James A Kaduk
The crystal structures of 16 new alkali metal citrates were determined using powder and/or single crystal techniques. These structures and 12 previously determined citrate structures were optimized using density functional techniques. The central portion of a citrate ion is fairly rigid, while the conformations of the terminal carboxylate groups exhibit no preferences. The citrate-metal bonding is ionic. Trends in metal-citrate coordination are noted. The energy of an O-H...O hydrogen bond is proportional to the square root of the H...
April 1, 2018: Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials
https://www.readbyqxmd.com/read/29607709/impact-of-food-quantity-and-quality-on-the-biochemical-risk-of-renal-stone-formation
#17
Francesco Esperto, Roberto Miano, Martino Marangella, Alberto Trinchieri
OBJECTIVE: This study evaluated the role of body mass index (BMI) and dietary potential renal acid load (PRAL) with urinary saturation for calcium oxalate (US-CaOx), calcium phosphate (US-CaP) and uric acid (US-UA) in renal stone formers. MATERIALS AND METHODS: A retrospective analysis was conducted of laboratory data collected on 442 renal stone-forming patients. Demographic information, BMI and 24 h urinary samples were collected from patients on their regular diets...
April 1, 2018: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/29597267/study-on-the-visible-light-photocatalytic-performance-and-degradation-mechanism-of-diclofenac-sodium-under-the-system-of-hetero-structural-cubi%C3%A2-o%C3%A2-ag%C3%A2-po%C3%A2-with-h%C3%A2-o%C3%A2
#18
Xiaojuan Chen, Ning Li, Song Xu, Hailong Wang, Yumin Cai
Two kinds of CuBi₂O₄/Ag₃PO₄ with different heterojunction structures were prepared based on the combination of hydrothermal and in-situ precipitation methods with surfactant additives (sodium citrate and sodium stearate), and their characteristics were systematically resolved by X-ray Diffraction (XRD), Brunauer-Emmett-Teller (BET), X-ray Photoelectron Spectroscopy (XPS), Scanning Electron Microscope (SEM)/ High-resolution Transmission Electron Microscopy (HRTEM), UV-vis Diffuse Reflectance Spectra (DRS) and Photoluminescence (PL)...
March 28, 2018: Materials
https://www.readbyqxmd.com/read/29593662/petrophilic-fe-iii-reducing-exoelectrogen-citrobacter-sp-kvm11-isolated-from-hydrocarbon-fed-microbial-electrochemical-remediation-systems
#19
Krishnaveni Venkidusamy, Ananda Rao Hari, Mallavarapu Megharaj
Exoelectrogenic biofilms capable of extracellular electron transfer are important in advanced technologies such as those used in microbial electrochemical remediation systems (MERS) Few bacterial strains have been, nevertheless, obtained from MERS exoelectrogenic biofilms and characterized for bioremediation potential. Here we report the identification of one such bacterial strain, Citrobacter sp. KVM11, a petrophilic, iron reducing bacterial strain isolated from hydrocarbon fed MERS, producing anodic currents in microbial electrochemical systems...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29554895/palmitoleic-acid-16-1n7-increases-oxygen-consumption-fatty-acid-oxidation-and-atp-content-in-white-adipocytes
#20
Maysa M Cruz, Andressa B Lopes, Amanda R Crisma, Roberta C C de Sá, Wilson M T Kuwabara, Rui Curi, Paula B M de Andrade, Maria I C Alonso-Vale
BACKGROUND: We have recently demonstrated that palmitoleic acid (16:1n7) increases lipolysis, glucose uptake and glucose utilization for energy production in white adipose cells. In the present study, we tested the hypothesis that palmitoleic acid modulates bioenergetic activity in white adipocytes. METHODS: For this, 3 T3-L1 pre-adipocytes were differentiated into mature adipocytes in the presence (or absence) of palmitic (16:0) or palmitoleic (16:1n7) acid at 100 or 200 μM...
March 20, 2018: Lipids in Health and Disease
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