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https://www.readbyqxmd.com/read/28337215/root-adaptive-responses-to-aluminum-treatment-revealed-by-rna-seq-in-two-citrus-species-with-different-aluminum-tolerance
#1
Peng Guo, Yi-Ping Qi, Lin-Tong Yang, Ning-Wei Lai, Xin Ye, Yi Yang, Li-Song Chen
Seedlings of aluminum (Al)-tolerant Citrus sinensis and Al-intolerant Citrus grandis were fertigated daily with nutrient solution containing 0 and 1.0 mM AlCl3●6H2O for 18 weeks. The Al-induced decreases of biomass and root total soluble proteins only occurred in C. grandis, demonstrating that C. sinensis had higher Al-tolerance than C. grandis. Under Al-treatment, C. sinensis roots secreted more citrate and malate than C. grandis ones; less Al was accumulated in C. sinenis than in C. grandis leaves. The Al-induced reduction of phosphorus was lesser in C...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28337027/obesity-induced-decreases-in-muscle-performance-are-not-reversed-by-weight-loss
#2
F Seebacher, J Tallis, K McShea, R S James
BACKGROUND/OBJECTIVES: Obesity can affect muscle phenotypes, and may thereby constrain movement and energy expenditure. Weight loss is a common and intuitive intervention for obesity, but it is not known whether the effects of obesity on muscle function are reversible by weight loss. Here we tested whether obesity-induced changes in muscle metabolic and contractile phenotypes are reversible by weight loss. SUBJECTS/METHODS: We used zebrafish (Danio rerio) in a factorial design to compare energy metabolism, locomotor capacity, muscle isometric force and work-loop power output, and myosin heavy chain composition between lean fish, diet-induced obese fish, and fish that were obese and then returned to lean body mass following diet restriction...
March 24, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28336129/labile-iron-potentiates-ascorbate-dependent-reduction-and-mobilization-of-ferritin-iron
#3
Charles Badu-Boateng, Sofia Pardalaki, Claude Wolf, Sonia Lajnef, Fabienne Peyrot, Richard J Naftalin
Ascorbate mobilizes iron from equine spleen ferritin by two separate processes. Ascorbate alone mobilizes ferritin iron with an apparent Km (ascorbate) ≈1.5mM. Labile iron >2μM, complexed with citrate (10mM), synergises ascorbate-dependent iron mobilization by decreasing the apparent Km (ascorbate) to ≈270μM and raising maximal mobilization rate by ≈5-fold. Catalase reduces the apparent Km(ascorbate) for both ascorbate and ascorbate+iron dependent mobilization by ≈80%. Iron mobilization by ascorbate alone has a higher activation energy (Ea=45...
March 21, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28327992/cyst-fluid-from-cystic-malignant-brain-tumors-a-reservoir-of-nutrients-including-growth-factor-like-nutrients-for-tumor-cells
#4
Daniel Dahlberg, Eduard A Struys, Erwin E Jansen, Lars Mørkrid, Øivind Midttun, Bjørnar Hassel
BACKGROUND: Brain tumors may have cysts, whose content of nutrients could influence tumor cell microenvironment and growth. OBJECTIVE: To measure nutrients in cyst fluid from glioblastoma multiforme (GBM) and metastatic brain tumors. METHODS: Quantification of nutrients in cyst fluid from 12 to 18 GBMs and 4 to 10 metastatic brain tumors. RESULTS: GBM cysts contained glucose at 2.2 mmol/L (median value; range <0.8-3...
January 25, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28327741/new-polyaminocarboxylate-macrocycles-containing-phenolate-binding-units-synthesis-luminescent-and-relaxometric-properties-of-their-lanthanide-complexes
#5
Morgane Enel, Nadine Leygue, Stéphane Balayssac, Sophie Laurent, Chantal Galaup, Luce Vander Elst, Claude Picard
The synthesis of two new polyaminocarboxylate macrocycles incorporating one or two intracyclic phenol units (H4L(1) and H8L(2), respectively) is described. The 12-membered H4L(1) macrocycle leads to soluble and stable mononuclear Ln(III) complexes of [(L(1))Ln(H2O)2](-) composition (Ln = Eu, Tb and Gd) in aqueous solutions. In Tris buffer (pH 7.4), the [(L(1))Tb(H2O)2](-) complex displays a suitable efficiency for sensitized emission (ηsens = 48%) and a high luminescence quantum yield (Φ = 22%), which is worthy of note for a bis-hydrated terbium complex...
March 22, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28327718/can-charged-colloidal-particles-increase-the-thermoelectric-energy-conversion-efficiency
#6
Thomas J Salez, Bo Tao Huang, Maud Rietjens, Marco Bonetti, Cécile Wiertel-Gasquet, Michel Roger, Cleber Lopes Filomeno, Emmanuelle Dubois, Régine Perzynski, Sawako Nakamae
Currently, liquid thermocells are receiving increasing attention as an inexpensive alternative to conventional solid-state thermoelectrics for low-grade waste heat recovery applications. Here we present a novel path to increase the Seebeck coefficient of liquid thermoelectric materials using charged colloidal suspensions; namely, ionically stabilized magnetic nanoparticles (ferrofluids) dispersed in aqueous potassium ferro-/ferri-cyanide electrolytes. The dependency of thermoelectric potential on experimental parameters such as nanoparticle concentration and types of solute ions (lithium citrate and tetrabutylammonium citrate) is examined to reveal the relative contributions from the thermogalvanic potential of redox couples and the entropy of transfer of nanoparticles and ions...
March 22, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28321925/effects-of-6-months-aerobic-interval-training-on-skeletal-muscle-metabolism-in-middle-aged-metabolic-syndrome-patients
#7
A Guadalupe-Grau, V E Fernández-Elías, J F Ortega, F Dela, J W Helge, R Mora Rodríguez
AIM: Aerobic interval training (AIT) improves the health of metabolic syndrome patients (MetS) more than moderate intensity continuous training. However, AIT has not been shown to reverse all metabolic syndrome risk factors, possibly due to the limited duration of the training programs. PURPOSE: To assess the effects of 6 months of AIT on cardio-metabolic health and muscle metabolism in middle aged MetS. METHODS: Eleven MetS (54.5 ± 0.7 yrs old) underwent 6 month of 3 days a week supervised AIT program on a cycle-ergometer...
March 21, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28319140/role-of-muscle-il-6-in-gender-specific-metabolism-in-mice
#8
Amalia Molinero, Antonio Fernandez-Perez, Aina Mogas, Mercedes Giralt, Gemma Comes, Olaya Fernandez-Gayol, Mario Vallejo, Juan Hidalgo
The aim of the present work was to further explore the physiological roles of muscle-derived IL-6. Adult-floxed and conditional skeletal muscle IL-6 knock out male and female mice were used to study energy expenditure (indirect calorimetry at rest and during treadmill exercise, and body temperature cycle during the light phase) and energy intake (response to fast/refeeding). We also evaluated the responses to leptin and the activity of the insulin signalling pathway in skeletal muscle and liver by phosphorylation of Akt at Ser 473...
2017: PloS One
https://www.readbyqxmd.com/read/28300753/krebs-cycle-intermediates-protective-against-oxidative-stress-by-modulating-the-level-of-reactive-oxygen-species-in-neuronal-ht22-cells
#9
Kenta Sawa, Takumi Uematsu, Yusuke Korenaga, Ryuya Hirasawa, Masatoshi Kikuchi, Kyohei Murata, Jian Zhang, Xiaoqing Gai, Kazuichi Sakamoto, Tomoyuki Koyama, Takumi Satoh
Krebs cycle intermediates (KCIs) are reported to function as energy substrates in mitochondria and to exert antioxidants effects on the brain. The present study was designed to identify which KCIs are effective neuroprotective compounds against oxidative stress in neuronal cells. Here we found that pyruvate, oxaloacetate, and α-ketoglutarate, but not lactate, citrate, iso-citrate, succinate, fumarate, or malate, protected HT22 cells against hydrogen peroxide-mediated toxicity. These three intermediates reduced the production of hydrogen peroxide-activated reactive oxygen species, measured in terms of 2',7'-dichlorofluorescein diacetate fluorescence...
March 16, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28298542/lipid-emulsion-added-to-a-liquid-high-carbohydrate-diet-and-voluntary-running-exercise-reduce-lipogenesis-and-ameliorate-early-stage-hepatic-steatosis-in-mice
#10
Kuan-Hsun Huang, Lei Hao, Philip B Smith, Connie J Rogers, Andrew D Patterson, A Catharine Ross
Background: The use of parenteral nutrition formulas is often associated with the development of hepatic steatosis. We have shown previously that the addition of a lipid emulsion (LE) rich in n-6 (ω-6) fatty acids (FAs) ameliorated triglyceride (TG) accumulation in the livers of nonobese mice fed a high-carbohydrate diet (HCD) for 5 wk. However, it remains unclear how rapidly this condition develops and whether it can be prevented by LE with or without a running wheel for voluntary exercise (Exe).Objective: We investigated in an 8-d study whether mice develop steatosis and whether the administration of LE with or without Exe reduces the concentration of total FAs and prevents an increase in the expression of genes in the liver associated with lipogenesis...
March 15, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28295356/red-blood-cell-metabolic-responses-to-refrigerated-storage-rejuvenation-and-frozen-storage
#11
Angelo D'Alessandro, Alan D Gray, Zbignew M Sczcepiorkowski, Kirk Hansen, Louise H Herschel, Larry J Dumont
BACKGROUND: Storage of red blood cells (RBCs) under blood bank conditions promotes metabolic modulation within the RBC. This "metabolic storage lesion" may affect the quality and safety of the transfused RBCs. The aim of this study is to determine the metabolic changes in stored RBCs over 42 days of routine storage followed by a US Food and Drug Administration-approved method of rejuvenation, freezing, and preparation for transfusion. STUDY DESIGN AND METHODS: We exploited a mass spectrometry-based metabolomics approach to monitor 42-day-stored citrate phosphate dextrose/AS-1 RBCs (n = 29) that were rejuvenated, glycerolized and frozen, then thawed and deglycerolized, and held for 24 hours at 1 to 6ºC in saline-glucose...
March 10, 2017: Transfusion
https://www.readbyqxmd.com/read/28273879/development-of-fluorescent-fret-probes-for-off-on-detection-of-l-cysteine-based-on-gold-nanoparticles-and-porous-silicon-nanoparticles-in-ethanol-solution
#12
Hongyan Zhang, Zhenhong Jia
A new type of fluorescence "off-on" probe was designed for L-Cysteine (L-Cys) based on the fluorescence resonance energy transfer (FRET) between negatively charged amino-capped porous silicon nanoparticles (SiNPs) and positively charged citrate-stabilized Au nanoparticles (AuNPs). In this proposed FRET immunosensor, novel water-soluble amino-conjugated porous SiNPs in ethanol with excellent photoluminescence properties act as the energy donor. Excellent quenching efficiency between SiNPs-ethanol and citrate-stabilized AuNPs by electrostatic interaction via FRET provides an ideal "off-state" (turn-off)...
March 5, 2017: Sensors
https://www.readbyqxmd.com/read/28270771/glucose-metabolism-in-the-progression-of-prostate-cancer
#13
REVIEW
Francesca Cutruzzolà, Giorgio Giardina, Marina Marani, Alberto Macone, Alessandro Paiardini, Serena Rinaldo, Alessio Paone
Prostate cancer is one of the most common types of cancer in western country males but the mechanisms involved in the transformation processes have not been clearly elucidated. Alteration in cellular metabolism in cancer cells is recognized as a hallmark of malignant transformation, although it is becoming clear that the biological features of metabolic reprogramming not only differ in different cancers, but also among different cells in a type of cancer. Normal prostate epithelial cells have a peculiar and very inefficient energy metabolism as they use glucose to synthesize citrate that is secreted as part of the seminal liquid...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28264506/plasma-membrane-na%C3%A2-%C2%BA-coupled-citrate-transporter-slc13a5-and-neonatal-epileptic-encephalopathy
#14
REVIEW
Yangzom D Bhutia, Jonathan J Kopel, John J Lawrence, Volker Neugebauer, Vadivel Ganapathy
SLC13A5 is a Na⁺-coupled transporter for citrate that is expressed in the plasma membrane of specific cell types in the liver, testis, and brain. It is an electrogenic transporter with a Na⁺:citrate(3-) stoichiometry of 4:1. In humans, the Michaelis constant for SLC13A5 to transport citrate is ~600 μM, which is physiologically relevant given that the normal concentration of citrate in plasma is in the range of 150-200 μM. Li⁺ stimulates the transport function of human SLC13A5 at concentrations that are in the therapeutic range in patients on lithium therapy...
February 28, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28252223/chronic-effects-of-copper-in-oysters-crassostrea-hongkongensis-under-different-exposure-regimes-as-shown-by-nmr-based-metabolomics
#15
Chen Cao, Wen-Xiong Wang
Traditional metal toxicity tests on organisms have mainly focused on continuous exposure at a fixed concentration. However, organisms are more likely exposed to pollutants intermittently in estuarine environments that are significantly impacted by anthropogenic activity. The present study examined whether different copper (Cu) exposure regimes at an equivalent dose can induce different metabolomics effects on the oysters. An estuarine oyster Crassostrea hongkongensis was exposed to Cu continuously or intermittently at an equal dose (time × concentration) for 6 wk...
March 2, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28229388/effects-of-boron-supplementation-on-peripartum-dairy-cows-health
#16
Abdullah Basoglu, Nuri Baspinar, Leonardo Tenori, Alessia Vignoli, Erdem Gulersoy
Although many different dietary studies on the prevention of negative energy balance related diseases are often encountered, this is the first study investigating the effects of boron supplementation on peripartum dairy cows' health in the light of an omics approach. Twenty-eight healthy cows (1 control and 3 experimental groups) were enrolled from 2 months before predicted calving until 2 months after calving. Experimental groups were assigned to receive boron at increasing doses as an oral bolus. Production parameters, biochemical profile, Nuclear Magnetic Resonance based metabolomics profile, and mRNA abundance of gluconeogenic enzymes and lipid oxidation genes were determined...
February 22, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28221389/optical-electrical-and-magnetic-properties-of-lanthanum-strontium-manganite-la1-xsrxmno3-synthesized-through-the-citrate-combustion-method
#17
Ali Omar Turky, Mohamed Mohamed Rashad, Ali Mostafa Hassan, Elsayed M Elnaggar, Mikhael Bechelany
Generally, strontium-doped lanthanum manganites (LSM) are materials connected ordinarily as cathodes in the solid oxide fuel cell (SOFC). In this study, the structural, optical, electrical and magnetic properties of La1-xSrxMnO3 (x = 0.2, 0.5, 0.8) synthesized using an organic acid precursor strategy were investigated, based on using citric acid as a fuel. Evidently, the results disclosed that a pure single monoclinic LSM phase was obtained from the thermally treated precursors annealed at 1000 °C with an annealing time of 2 h...
February 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28220896/mitochondrial-dysregulation-secondary-to-endoplasmic-reticulum-stress-in-autosomal-dominant-tubulointerstitial-kidney-disease-umod-adtkd-umod
#18
Elisabeth Kemter, Thomas Fröhlich, Georg J Arnold, Eckhard Wolf, Rüdiger Wanke
'Autosomal dominant tubulointerstitial kidney disease - UMOD' (ADTKD-UMOD) is caused by impaired maturation and secretion of mutant uromodulin (UMOD) in thick ascending limb of Henle loop (TAL) cells, resulting in endoplasmic reticulum (ER) stress and unfolded protein response (UPR). To gain insight into pathophysiology, we analysed proteome profiles of TAL-enriched outer renal medulla samples from ADTKD-UMOD and control mice by quantitative LC-MS/MS. In total, 212 differentially abundant proteins were identified...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28219702/genetic-alterations-in-krebs-cycle-and-its-impact-on-cancer-pathogenesis
#19
REVIEW
Karishma Sajnani, Farhadul Islam, Robert Anthony Smith, Vinod Gopalan, Alfred King-Yin Lam
Cancer cells exhibit alterations in many cellular processes, including oxygen sensing and energy metabolism. Glycolysis in non-oxygen condition is the main energy production process in cancer rather than mitochondrial respiration as in benign cells. Genetic and epigenetic alterations of Krebs cycle enzymes favour the shift of cancer cells from oxidative phosphorylation to anaerobic glycolysis. Mutations in genes encoding aconitase, isocitrate dehydrogenase, succinate dehydrogenase, fumarate hydratase, and citrate synthase are noted in many cancers...
April 2017: Biochimie
https://www.readbyqxmd.com/read/28217349/crystal-structure-of-dicesium-hydrogen-citrate-from-laboratory-single-crystal-and-powder-x-ray-diffraction-data-and-dft-comparison
#20
Alagappa Rammohan, Amy A Sarjeant, James A Kaduk
The crystal structure of dicesium hydrogen citrate, 2Cs(+)·C6H6O7(2-), has been solved using laboratory X-ray single-crystal diffraction data, refined using laboratory powder X-ray data, and optimized using density functional techniques. The Cs(+) cation is nine-coordinate, with a bond-valence sum of 0.92 valence units. The CsO9 coordination polyhedra share edges and corners to form a three-dimensional framework. The citrate anion is located on a mirror plane. Its central hy-droxy/carboxyl-ate O-H⋯O hydrogen bond is short, and (unusually) inter-molecular...
February 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
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