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https://www.readbyqxmd.com/read/29152896/trimetazidine-restores-the-positive-adaptation-to-exercise-training-by-mitigating-statin-induced-skeletal-muscle-injury
#1
Ming Song, Fang-Fang Chen, Yi-Hui Li, Lei Zhang, Feng Wang, Ran-Ran Qin, Zhi-Hao Wang, Ming Zhong, Meng-Xiong Tang, Wei Zhang, Lu Han
BACKGROUND: Exercise rehabilitation is demonstrated to improve the prognosis of patients with coronary heart disease (CHD). Statins, as the key medicine to lower cholesterol in CHD, result in skeletal muscle injury and impair exercise training adaptation. Energy metabolism dysfunction is identified as the potential mechanism underlying statin-induced skeletal muscle injury. In this study, we investigated the effects of the metabolic modulator trimetazidine on skeletal muscle energy metabolism and statin-associated exercise intolerance...
November 19, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29151592/diet-resistant-obesity-is-characterized-by-a-distinct-plasma-proteomic-signature-and-impaired-muscle-fiber-metabolism
#2
A B Thrush, G Antoun, M Nikpay, D A Patten, C DeVlugt, J-F Mauger, B L Beauchamp, P Lau, R Reshke, É Doucet, P Imbeault, R Boushel, D Gibbings, J Hager, A Valsesia, R Slack, O Y Al-Dirbashi, R Dent, R McPherson, M-E Harper
BACKGROUND/OBJECT: Inter-individual variability in weight loss during obesity treatment is complex and poorly understood. Here we use whole body and tissue approaches to investigate fuel oxidation characteristics in skeletal muscle fibers, cells, and distinct circulating protein biomarkers before and after a high fat meal (HFM) challenge in those who lost the most (obese diet-sensitive; ODS), vs the least (obese diet-resistant; ODR) amount of weight in a highly controlled weight management program...
November 20, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29137472/changes-in-transcription-pattern-lead-to-a-marked-decrease-in-cox-cs-and-sqr-activity-after-the-developmental-point-of-the-22-nd-gestational-week
#3
H Kolarova, J Krizova, M Hulkova, H Hansikova, H Hulkova, V Smid, J Zeman, T Honzik, M Tesarova
Tissue differentiation and proliferation throughout fetal development interconnect with changes in the Oxidative Phosphorylation System (OXPHOS) on the cellular level. Reevaluation of the expression data revealed a significant increase in COX4 and MTATP6 liver transcription levels after the 22(nd) gestational week (GW) which inspired us to characterize its functional impact. Specific activities of cytochrome c oxidase (COX), citrate synthase (CS), succinate-coenzyme Q reductase (SQR) and mtDNA determined by spectrophotometry and RT-PCR were studied in a set of 25 liver and 18 skeletal muscle samples at 13(th) to 29(th) GW...
November 10, 2017: Physiological Research
https://www.readbyqxmd.com/read/29129060/alternate-reductants-with-vb12-to-transform-c8-and-c6-perfluoroalkyl-sulfonates-limitations-and-insights-into-isomer-specific-transformation-rates-products-and-pathways
#4
Saerom Park, Chloe de Perre, Linda S Lee
Previous studies evaluating Vitamin B12 (VB12) with Ti(III)-citrate for potential use in in situ remediation of perfluorooctanesulfonate (PFOS) found that linear (L)-PFOS was unaltered. We explored if alternate reductants could overcome this limitation with a primary focus on nanoscale zerovalent zinc (nZn(0)). Transformation over time with VB12-nZn(0) was quantified at 22, 70, and 90 °C for PFOS, at 70 °C for perfluorohexanesulfonate (PFHxS), and VB12-nFe(0) and VB12-Pd(0)/nFe(0) at 70 °C for PFOS. Only branched (br-) isomers were transformed generating F(-) (no SO4(2-)) and polyfluoroalkyl intermediates/products...
November 20, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29122174/differential-gene-expression-profiling-analysis-in-pleurotus-ostreatus-during-interspecific-antagonistic-interactions-with-dichomitus-squalens-and-trametes-versicolor
#5
Zixuan Zhong, Liu Li, Peng Chang, Haiying Xie, Huiting Zhang, Yasuo Igarashi, Nannan Li, Feng Luo
This study provided analysis of differentially expressed genes (DEGs) in Pleurotus ostreatus under the interaction with Dichomitus squalens and Trametes versicolor, which is valuable for exploration on the fungal defence system against stressful condition caused by interspecific antagonistic interaction. Our result showed significant upregulation of abundant defence-related genes encoding laccase, manganese peroxidase, aldo-keto reductase, and glutathione S-transferase, which all play important roles in oxidative stress-resistant response...
December 2017: Fungal Biology
https://www.readbyqxmd.com/read/29119568/unchanged-mitochondrial-phenotype-but-accumulation-of-lipids-in-the-myometrium-in-obese-pregnant-women
#6
Christiane Marie Bourgin Folke Gam, Lea Hüche Larsen, Ole Hartvig Mortensen, Line Engelbrechtsen, Steen Seier Poulsen, Klaus Qvortrup, Elisabeth Reinhart Mathiesen, Peter Damm, Bjørn Quistorff
KEY POINTS: Obesity during pregnancy and childbirth is associated with labour dystocia leading to instrumental or operative delivery, but the underlying pathophysiological mechanisms remain unclear and insufficient uterine contractility has been suggested. This study examined whether reduced myometrial mitochondrial capacity or quantity could contribute as a pathophysiological mechanism to labour dystocia. Data did not support reduced myometrial mitochondrial capacity or quantity in the myometrium at term in obese women, but a reduced myocyte density with increased triglyceride content was demonstrated, which could lead to poorer uterine contractility...
November 9, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29116274/multicolour-nitrogen-doped-carbon-dots-tunable-photoluminescence-and-sandwich-fluorescent-glass-based-light-emitting-diodes
#7
Yijun Zhang, Rongrong Yuan, Meiling He, Guangcai Hu, Jutao Jiang, Tao Xu, Lei Zhou, Wei Chen, Weidong Xiang, Xiaojuan Liang
The first use of the combination of ammonium citrate (AC) and ethylenediamine tetraacetic acid (EDTA) as coordinating precursors for the synthesis of highly fluorescent (quantum yield = 67%) multicolour nitrogen-doped carbon dots (CDs) is reported. Under UV light, these CDs emitted outstanding luminescence in colours from dark blue to red. Interestingly, a single component white-light CD point with high fluorescence efficiency was obtained by surface control. Alterations of the photoluminescence (PL) emission of these full-colour CDs were tentatively proposed to benefit from surface functional groups, such as C[double bond, length as m-dash]O and C[double bond, length as m-dash]N...
November 8, 2017: Nanoscale
https://www.readbyqxmd.com/read/29104506/skeletal-muscle-specific-overexpression-of-pgc-1%C3%AE-induces-fiber-type-conversion-through-enhanced-mitochondrial-respiration-and-fatty-acid-oxidation-in-mice-and-pigs
#8
Lin Zhang, Ying Zhou, Wangjun Wu, Liming Hou, Hongxing Chen, Bo Zuo, Yuanzhu Xiong, Jinzeng Yang
Individual skeletal muscles in the animal body are heterogeneous, as each is comprised of different fiber types. Type I muscle fibers are rich with mitochondria, and have high oxidative metabolisms while type IIB fibers have few mitochondria and high glycolytic metabolic capacity. Peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α), a transcriptional co-activator that regulates mitochondrial biogenesis and respiratory function, is implicated in muscle fiber-type switching. Over-expression of PGC-1α in transgenic mice increased the proportion of red/oxidative type I fiber...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29103285/the-effect-of-dietary-asparagine-supplementation-on-energy-metabolism-in-liver-of-weaning-pigs-when-challenged-with-lipopolysaccharide
#9
Ping Kang, Yulan Liu, Huiling Zhu, Jing Zhang, Haifeng Shi, Shuang Li, Dingan Pi, Weibo Leng, Xiuying Wang, Huanting Wu, Yongqing Hou
Objective: This experiment was conducted to investigate whether asparagine (Asn) could improve liver energy status in the weaning pigs when challenged with lipopolysaccharide. Methods: Forty-eight weaned pigs (Duroc × Large White × Landrace, 8.12±0.56 kg) were assigned to four treatments: 1) CTRL, piglets received a control diet and injected with sterile 0.9% NaCl solution; 2) LPSCC, piglets received the same control diet and injected with Escherichia coli LPS; 3) LPS + 0...
November 3, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/29077704/variability-in-the-protein-profiles-in-spermatozoa-of-two-sturgeon-species
#10
Ping Li, Wei Guo, Huamei Yue, Chuangju Li, Hao Du, Xinmei Qiao, Zhigang Liu, Qiong Zhou, Qiwei Wei
Conventional sperm analysis (i.e., motility and fertility) has been used to evaluate sperm quality. Understanding the quality of sperm on the molecular level in the sturgeons, Acipenser baerii and A. schrenckii, is essential for the improvement of the conservation of genetic resources and farming performance. In this study, we used the iTRAQ proteomics approach to perform proteomic profiling of spermatozoa associated with sperm quality in sturgeons (Data are available via ProteomeXchange with identifier PXD006108)...
2017: PloS One
https://www.readbyqxmd.com/read/29056027/-differential-expression-of-micrornas-in-serum-of-severe-burn-patients-and-analysis-of-the-signaling-pathway-at-early-stage
#11
S Wang, Q F Ruan, W G Xie, L Chen, M J Jiang, J J Ruan, Z Q Ye
Objective: To explore differential expression of microRNAs in serum of patients with severe burn and analysis of the signaling pathway at early stage. Methods: In this study, we included three healthy adult volunteers and three patients with severe burn, conforming to the inclusion criteria and hospitalized in Tongren Hospital of Wuhan University & Wuhan Third Hospital in July 2015. Venous whole blood of 6 mL of each burn patient and healthy volunteer was collected at 24 to 48 h post injury of burn patients...
October 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29044214/limits-of-aerobic-metabolism-in-cancer-cells
#12
Jorge Fernandez-de-Cossio-Diaz, Alexei Vazquez
Cancer cells exhibit high rates of glycolysis and glutaminolysis. Glycolysis can provide energy and glutaminolysis can provide carbon for anaplerosis and reductive carboxylation to citrate. However, all these metabolic requirements could be in principle satisfied from glucose. Here we investigate why cancer cells do not satisfy their metabolic demands using aerobic biosynthesis from glucose. Based on the typical composition of a mammalian cell we quantify the energy demand and the OxPhos burden of cell biosynthesis from glucose...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29043335/remarkable-lowering-in-the-synthesis-temperature-of-limn2o4via-citrate-solution-gel-synthesis-facilitated-by-ethanol
#13
G Maino, R Carleer, W Marchal, G Bonneux, A Hardy, M K Van Bael
LiMn2O4 (LMO) is interesting from the viewpoint of its energy storage applications as it is a cathode in lithium ion batteries (LIB), which contains no rare, toxic or expansive elements, while it provides a high theoretical capacity (148 mA h g(-1)) at a reasonable voltage (4 V region) and a higher thermal stability compared to cobalt based cathodes and has a good rechargeability and cycling stability due to its spinel structure. Low temperature synthesis routes for cathode materials are currently gaining attention, in order to decrease the ecological footprint of the final LIB...
November 7, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29017174/cardiac-remodeling-induced-by-all-trans-retinoic-acid-is-detrimental-in-normal-rats
#14
Renata A C Silva, Andréa F Gonçalves, Priscila P Dos Santos, Bruna Rafacho, Renan F T Claro, Marcos F Minicucci, Paula S Azevedo, Bertha F Polegato, Silméia G Zanati, Ana Angélica Fernandes, Sergio A R Paiva, Leonardo A M Zornoff
BACKGROUND/AIMS: This study aimed to discern whether the cardiac alterations caused by retinoic acid (RA) in normal adult rats are physiologic or pathologic. METHODS AND RESULTS: Wistar rats were assigned into four groups: control animals (C, n = 20) received a standard rat chow; animals fed a diet supplemented with 0.3 mg/kg/day all-trans-RA (AR1, n = 20); animals fed a diet supplemented with 5 mg/kg/day all-trans-RA (AR2, n = 20); and animals fed a diet supplemented with 10 mg/kg/day all-trans-RA (AR3, n = 20)...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28954258/-hydroxycitric-acid-reduced-lipid-droplets-accumulation-via-decreasing-acetyl-coa-supply-and-accelerating-energy-metabolism-in-cultured-primary-chicken-hepatocytes
#15
Longlong Li, Mengling Peng, Chongyang Ge, Lei Yu, Haitian Ma
BACKGROUND/AIMS: (-)-Hydroxycitric acid (HCA) had been shown to suppress fat accumulation in animals and humans, while the underlying biochemical mechanism is not fully understood, especially little information is available on whether (-)-HCA regulates energy metabolism and consequently affects fat deposition. METHODS: Hepatocytes were cultured for 24 h and then exposed to (-)-HCA (0, 1, 10, 50 µM), enzyme protein content was determined by ELISA; lipid metabolism gene mRNA levels were detected by RT-PCR...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28947262/perfluorooctanoic-acid-exposure-disturbs-glucose-metabolism-in-mouse-liver
#16
Fei Zheng, Nan Sheng, Hongxia Zhang, Shengmin Yan, Jianhai Zhang, Jianshe Wang
Environmental pollutants such as perfluorooctanoic acid (PFOA) can influence human metabolism processes and are associated with certain metabolic diseases. To investigate the effect of PFOA on liver glucose homeostasis, adult male Balb/c mice were orally administered 1.25mg/kg of PFOA for 28d consecutively. Compared with the control mice, the body weights of the PFOA-treated mice were unchanged following exposure. However, PFOA exposure increased fasting blood glucose levels and decreased glycogen and glucose content in the liver of treated mice, but did not influence blood insulin significantly...
November 15, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28934963/metabolic-status-of-csf-distinguishes-rats-with-tauopathy-from-controls
#17
Radana Karlíková, Kateřina Mičová, Lukáš Najdekr, Alžběta Gardlo, Tomáš Adam, Petra Majerová, David Friedecký, Andrej Kováč
BACKGROUND: Tauopathies represent heterogeneous groups of neurodegenerative diseases that are characterised by abnormal deposition of the microtubule-associated protein tau. Alzheimer's disease is the most prevalent tauopathy, affecting more than 35 million people worldwide. In this study we investigated changes in metabolic pathways associated with tau-induced neurodegeneration. METHODS: Cerebrospinal fluid (CSF), plasma and brain tissue were collected from a transgenic rat model for tauopathies and from age-matched control animals...
September 21, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/28931857/eu-3-activated-la2moo6-la2wo6-red-emitting-phosphors-with-ultrabroad-excitation-band-for-white-light-emitting-diodes
#18
Peng Du, Jae Su Yu
A series of novel Eu(3+)-activated La2MoO6-La2WO6 red-emitting phosphors have been successfully prepared by a citrate-assisted sol-gel process. Both photoluminescence excitation and emission spectra suggest that the resultant products have the strong ultrabroad absorption band ranging from 220 to 450 nm. Under the excitation of 379 nm, the characteristic emissions of Eu(3+) ions corresponding to the (5)D0 → (7)F J transitions are observed in the doped samples. The optimal doping concentration for Eu(3+) ions is found to be 12 mol% and the quenching mechanism is attributed to the dipole-dipole interaction...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28928660/-1-h-nmr-based-metabolomics-study-of-the-toxicological-effects-in-rats-induced-by-renqing-mangjue-pill-a-traditional-tibetan-medicine
#19
Can Xu, Caidan Rezeng, Jian Li, Lan Zhang, Yujing Yan, Jian Gao, Yingfeng Wang, Zhongfeng Li, Jianxin Chen
"RenqingMangjue" pill (RMP), as an effective prescription of Traditional Tibetan Medicine (TTM), has been widely used in treating digestive diseases and ulcerative colitis for over a thousand years. In certain classical Tibetan Medicine, heavy metal may add as an active ingredient, but it may cause contamination unintentionally in some cases. Therefore, the toxicity and adverse effects of TTM became to draw public attention. In this study, 48 male Wistar rats were orally administrated with different dosages of RMP once a day for 15 consecutive days, then half of the rats were euthanized on the 15th day and the remaining were euthanized on the 30th day...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28928294/factors-affecting-reduction-of-reference-endotoxin-standard-activity-caused-by-chelating-agent-detergent-matrices-kinetic-analysis-of-low-endotoxin-recovery
#20
Masakazu Tsuchiya
Reduction of reference standard endotoxin (RSE) activity was kinetically analyzed under low endotoxin recovery (LER) conditions, and was considered as an apparent first-order reaction. Temperature, pH, and salt concentrations affected the rates of reduction of RSE activity. Temperature appeared to be the most important factor affecting LER. Components of LER matrices, such as citrate and polysorbate 20 showed similar LER effect at concentrations commonly used. Phosphate concentrations showed negative correlation against the half-life of RSE activity in solutions containing phosphate buffer and polysorbate 20...
September 19, 2017: PDA Journal of Pharmaceutical Science and Technology
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