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docosahexaenoic acid

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https://www.readbyqxmd.com/read/28817082/omega-3-long-chain-fatty-acids-in-the-heart-kidney-liver-and-plasma-metabolite-profiles-of-australian-prime-lambs-supplemented-with-pelleted-canola-and-flaxseed-oils
#1
Don V Nguyen, Van H Le, Quang V Nguyen, Bunmi S Malau-Aduli, Peter D Nichols, Aduli E O Malau-Aduli
The objective of the study was to ascertain whether human health beneficial omega-3 long-chain (≥C20) polyunsaturated fatty acid (n-3 LC-PUFA) content in heart, kidney and liver can be enhanced by supplementing prime lambs with graded levels of canola and flaxseed oil. Health status of the lambs, as a consequence of the supplementation, was also investigated by examining their plasma metabolites. Sixty purebred and first-cross lambs were allocated to one of five treatments of lucerne hay basal diet supplemented with isocaloric and isonitrogenous wheat-based pellets without oil inclusion (Control) or graded levels of canola oil at 2...
August 17, 2017: Nutrients
https://www.readbyqxmd.com/read/28817068/a-critical-review-on-the-effect-of-docosahexaenoic-acid-dha-on-cancer-cell-cycle-progression
#2
REVIEW
Marnie Newell, Kristi Baker, Lynne M Postovit, Catherine J Field
Globally, there were 14.1 million new cancer diagnoses and 8.2 million cancer deaths in 2012. For many cancers, conventional therapies are limited in their successes and an improved understanding of disease progression is needed in conjunction with exploration of alternative therapies. The long chain polyunsaturated fatty acid, docosahexaenoic acid (DHA), has been shown to enhance many cellular responses that reduce cancer cell viability and decrease proliferation both in vitro and in vivo. A small number of studies suggest that DHA improves chemotherapy outcomes in cancer patients...
August 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28812576/docosahexaenoic-acid-enrichment-in-nafld-is-associated-with-improvements-in-hepatic-metabolism-and-hepatic-insulin-sensitivity-a-pilot-study
#3
L Hodson, L Bhatia, E Scorletti, D E Smith, N C Jackson, F Shojaee-Moradie, M Umpleby, P C Calder, C D Byrne
This corrects the article DOI: 10.1038/ejcn.2017.9.
August 16, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28811832/dha-increases-adiponectin-expression-more-effectively-than-epa-at-relative-low-concentrations-by-regulating-ppar%C3%AE-and-its-phosphorylation-at-ser273-in-3t3-l1-adipocytes
#4
Jia Song, Cheng Li, Yushan Lv, Yi Zhang, William Kwame Amakye, Limei Mao
BACKGROUND: Enhancing circulating adiponectin is considered as a potential approach for the prevention and treatment of non-communicable diseases (NCDs). Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) were reported to increase adiponectin by previous studies using a mixture of them. However, their individual effects on adiponectin and the underlying mechanisms are still unclear. In the present study, we observed and compared the individual effect of DHA and EPA on adiponectin in 3T3-L1 adipocytes, and further tested whether DHA or EPA regulated adiponectin by peroxisome proliferator-activated receptor γ (PPARγ) and its phosphorylation at Ser273 to provide a plausible explanation for their distinct actions...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28810571/docosahexaenoic-acid-inhibits-the-phosphorylation-of-stat3-and-the-growth-and-invasion-of-renal-cancer-cells
#5
Shinsuke Tasaki, Akio Horiguchi, Takako Asano, Keiichi Ito, Tomohiko Asano, Hirotaka Asakura
Docosahexaenoic acid (DHA) has a variety of anti-tumor activities. The present study examined the anti-tumor activity of DHA in renal cancer cells and its underlying mechanisms of action. The effects of DHA on the viability and proliferation of the human renal cancer cell lines Caki-1 and 786-O were examined by an MTS assay and cell counting. In addition, cell cycle distribution and cell apoptosis were analyzed by flow cytometry and Annexin V staining, and modulation of cell mobility and invasiveness was assessed by wound healing and Matrigel invasion assays...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28807933/mice-deficient-in-lysophosphatidic-acid-acyltransferase-%C3%AE-lpaat%C3%AE-acylglycerophosphate-acyltransferase-4-agpat4-have-impairments-in-spatial-learning-and-memory-associated-with-reductions-in-nmda-and-ampa-receptors
#6
Ryan M Bradley, Emily B Mardian, Darin Bloemberg, Juan J Aristizabal Henao, Andrew S Mitchell, Phillip M Marvyn, Katherine A Moes, Ken D Stark, Joe Quadrilatero, Robin E Duncan
We previously characterized LPAATδ/AGPAT4 as a mitochondrial lysophosphatidic acid acyltransferase that regulates brain levels of phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylinositol (PI). Here we report that Lpaatδ (-/-) mice display impaired spatial learning and memory compared to wildtype littermates in the Morris Water Maze, and investigated potential mechanisms associated with brain phospholipid changes. Marker protein immunoblotting suggested that the relative brain content of neurons, glia, and oligodendrocytes was unchanged...
August 14, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28807874/docosahexaenoic-acid-increases-the-expression-of-oxidative-stress-induced-growth-inhibitor-1-through-the-pi3k-akt-nrf2-signaling-pathway-in-breast-cancer-cells
#7
Chia-Han Tsai, You-Cheng Shen, Haw-Wen Chen, Kai-Li Liu, Jer-Wei Chang, Pei-Yin Chen, Chen-Yu Lin, Hsien-Tsung Yao, Chien-Chun Li
Oxidative stress-induced growth inhibitor 1 (OSGIN1), a tumor suppressor, inhibits cell proliferation and induces cell death. N-6 and n-3 PUFAs protect against breast cancer, but the molecular mechanisms of this effect are not clear. We investigated the effect of n-6 and n-3 PUFAs on OSGIN1 expression and whether OSGIN1 is involved in PUFA-induced apoptosis in breast cancer cells. We used 100 μM of n-6 PUFAs including arachidonic acid, linoleic acid, and gamma-linolenic acid and n-3 PUFAs including alpha-linolenic acid, eicosapentaenoic acid, and docosahexaenoic acid (DHA)...
August 11, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28804463/effect-of-oral-docosahexaenoic-acid-dha-supplementation-on-dha-levels-and-omega-3-index-in-red-blood-cell-membranes-of-breast-cancer-patients
#8
Alessio Molfino, Maria I Amabile, Sara Mazzucco, Gianni Biolo, Alessio Farcomeni, Cesarina Ramaccini, Simonetta Antonaroli, Massimo Monti, Maurizio Muscaritoli
Rationale: Docosahexaenoic acid (DHA) in cell membrane may influence breast cancer (BC) patients' prognosis, affecting tumor cells sensitivity to chemo- and radio-therapy and likely modulating inflammation. The possibility of identifying BC patients presenting with low DHA levels and/or low ability of DHA incorporation into cell membrane might help to treat this condition. Methods: We enrolled BC patients and healthy controls, recording their seafood dietary intake. DHA in form of algal oil was administered for 10 consecutive days (2 g/day)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28803650/lipid-determination-in-bone-marrow-and-mineralized-bone-tissue-from-sample-preparation-to-improved-high-performance-thin-layer-and-liquid-chromatographic-approaches
#9
Alexandrine During
In view of their key roles in the bone physiology (e.g., in the biomineralization process) and their potential implication in bone pathologies, an approach to study lipids in situ is needed. The aim of the present paper is to propose an original procedure to characterize lipids in both bone marrow (BM) and mineralized tissue (MT) compartments, taking into consideration sample preparation, lipid extraction and analytical issues, when using small sample size (≤ 0.5g of rat femurs). The potential contamination of the MT by marrow lipids and the poor accessibility of certain lipids from the MT - two major issues in bone handling - were taking care, respectively by performing two cleaning steps after BM removal and by adding a demineralization step to the overall lipid extraction protocol...
August 3, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28802572/effect-of-cadmium-on-uptake-of-iron-zinc-and-copper-and-mrna-expression-of-metallothioneins-in-hepg2-cells-in-vitro
#10
Sabine Sampels, Hana Kocour Kroupova, Pavla Linhartova
The intake of cadmium contaminated fish was mimicked by incubating human hepatoblastoma cells (Cell line HepG2) with a combination of different levels of cadmium (0-5μM) plus the n-3 fatty acids docosahexaenoic acid and eicosapentaenoic acid, which are typical for fish. Uptake of cadmium, iron, copper and zinc was measured by ICP-MS. In addition mRNA expression of two metallothioneins (mt1 g and mt1 m) was evaluated by real-time PCR. The obtained data shows that the presence of cadmium increases the uptake of iron and zinc into the HepG2 cells while the uptake of copper remains unaffected...
August 10, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28802571/omega-3-polyunsaturated-fatty-acids-improve-endothelial-function-in-humans-at-risk-for-atherosclerosis-a-review
#11
REVIEW
Kayla R Zehr, Mary K Walker
Epidemiology studies and clinical trials show that omega-3 polyunsaturated fatty acids (n-3 PUFAs) can prevent atherosclerotic morbidity and evidence suggests this may be mediated by improving endothelial dysfunction. Endothelial dysfunction is characterized by reduced vasodilation and a pro-inflammatory, pro-thrombotic state, and is an early pathological event in the development of atherosclerosis. Flow-mediated dilation (FMD), a gold standard for assessing endothelial dysfunction, is a predictor of future cardiovascular events and coronary heart disease risk...
August 9, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28797567/docosahexaenoic-acid-induces-glial-cell-line-derived-neurotrophic-factor-release-in-c6-glioma-cells-implications-of-antidepressant-effects-for-docosahexaenoic-acid
#12
Lanqiu Zhang, Zhuoran Zhu, Zhoubin Tan, Hongyan Luo, Xinwu Hu, Yan Li
Dietary deficiency of n-3 polyunsaturated fatty acids (PUFAs) is involved in the pathophysiology and etiology of major depressive disorder. Supplementation with docosahexaenoic acid (DHA) exerts antidepressant-like effect; however, the molecular mechanism of DHA action remains unclear. Here we examined the effects of DHA on the modulation of glial cell line-derived neurotrophic factor (GDNF), which is essential for neural development, plasticity, neurogenesis, and survival. We demonstrated that DHA treatment significantly increased GDNF release in a concentration dependent manner in rat C6 glioma cells (C6 cells) and primary cultured rat astrocytes, which is also associated with increased expression of GDNF mRNA...
August 7, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28797250/omega-3-fatty-acids-eicosapentaenoic-acid-and-docosahexaenoic-acid-and-their-mechanisms-of-action-on-apolipoprotein-b-containing-lipoproteins-in-humans-a-review
#13
REVIEW
Jan Oscarsson, Eva Hurt-Camejo
BACKGROUND: Epidemiological and genetic studies suggest that elevated triglyceride (TG)-rich lipoprotein levels in the circulation increase the risk of cardiovascular disease. Prescription formulations of omega-3 fatty acids (OM3FAs), mainly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), reduce plasma TG levels and are approved for the treatment of patients with severe hypertriglyceridemia. Many preclinical studies have investigated the TG-lowering mechanisms of action of OM3FAs, but less is known from clinical studies...
August 10, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28795377/comparison-of-the-fatty-acid-profile-of-spanish-infant-formulas-and-galician-women-breast-milk
#14
Rocío Barreiro, Patricia Regal, Olga López-Racamonde, Alberto Cepeda, Cristina A Fente
The importance of dietary lipids during childhood is evident, as they are necessary for correct growth and development of the newborn. When breastfeeding is not possible, infant formulas are designed to mimic human milk as much as possible to fulfill infant's requirements. However, the composition of these dairy products is relatively constant, while human milk is not a uniform bio-fluid and changes according to the requirements of the baby. In this study, breast milk samples were donated by 24 Spanish mothers in different lactation stages and different infant formulas were purchased in supermarkets and pharmacies...
August 9, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28790921/fatty-acid-profile-of-neutral-and-polar-lipid-fraction-of-wild-eggs-and-hatchlings-from-wild-and-captive-reared-broodstock-of-octopus-vulgaris
#15
Juan Estefanell, Antonio Mesa-Rodríguez, Besay Ramírez, Antonio La Barbera, Juan Socorro, Carmen María Hernandez-Cruz, María Soledad Izquierdo
The culture of Octopus vulgaris is constrained by unsolved problems in paralarvae rearing, mainly associated to the unknown nutritional requirements of this species in early stages. In this article we studied the fatty acid profile (total, neutral, and polar lipid fractions) in wild eggs and wild hatchlings, collected in Gran Canaria (SW) (Spain) with artificial dens, in comparison to hatchlings obtained in captivity from broodstock fed on trash fish species. Total lipids were 11.5-13.5% dw, with the polar fraction representing a 70...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28790013/chronic-vitamin-e-deficiency-impairs-cognitive-function-in-adult-zebrafish-via-dysregulation-of-brain-lipids-and-energy-metabolism
#16
Melissa McDougall, Jaewoo Choi, Kathy Magnusson, Lisa Truong, Robert Tanguay, Maret G Traber
Zebrafish (Danio rerio) are a recognized model for studying the pathogenesis of cognitive deficits and the mechanisms underlying behavioral impairments, including the consequences of increased oxidative stress within the brain. The lipophilic antioxidant vitamin E (α-tocopherol; VitE) has an established role in neurological health and cognitive function, but the biological rationale for this action remains unknown. In the present study, we investigated behavioral perturbations due to chronic VitE deficiency in adult zebrafish fed from 45 days to 18-months of age diets that were either VitE-deficient (E-) or VitE-sufficient (E+)...
August 5, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28783061/impact-of-biological-feedback-and-incentives-on-blood-fatty-acid-concentrations-including-omega-3-index-in-an-employer-based-wellness-program
#17
Michael I McBurney, Julia K Bird
Eicosapentaenoic acid (EPA, C20:5n-3) and docosahexaenoic acid (DHA, C22:6n-3) are important fatty acids for the retina and brain. More than 95% of Americans have suboptimal EPA + DHA blood concentrations. This cross-sectional employer-based study assessed whole blood fatty acid levels of volunteers participating in an onsite wellness biometric screening program and was designed to determine if an incentive, a $5 coupon for a 90-day supply of fish oil supplement typically costing $18-30, stimulated incremental dietary behavior change relative to nutritional status assessment alone to increase EPA + DHA concentrations...
August 5, 2017: Nutrients
https://www.readbyqxmd.com/read/28782808/lipid-composition-of-membrane-microdomains-isolated-detergent-free-from-pufa-supplemented-raw264-7-macrophages
#18
Christine Hellwing, Feven Tigistu-Sahle, Herbert Fuhrmann, Reijo Käkelä, Julia Schumann
Profound alterations in the lipid profile of raft and non-raft plasma membrane microdomains were found when RAW264.7 macrophages were supplemented with polyunsaturated fatty acids (PUFAs) in physiologically relevant concentrations. For the first time lipids in the detergent-free isolated membrane domains of phagocytic immune cells were characterized by mass spectrometry. The extent of remodeling of the membrane lipids differed with different n3 and n6 PUFA supplements. The mildest effects were detected for -linolenic acid (LNA) and linoleic acid (LA), the C18 precursors of the n3 and n6 families, respectively...
August 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28781788/inhibition-of-pc3-human-prostate-cancer-cell-proliferation-invasion-and-migration-by-eicosapentaenoic-acid-and-docosahexaenoic-acid
#19
Keiichi Oono, Katsuya Takahashi, Saeka Sukehara, Hirohito Kurosawa, Tomio Matsumura, Shun'Ichiro Taniguchi, Shoichiro Ohta
The n-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), found in fish oil, exert a number of beneficial effects, and they are used in the treatment of hyperlipidemia. In recent years, EPA and DHA have been found to affect cancer cell proliferation. In the present study, PC3 cells, which are androgen-independent prostate cancer cells that resemble castration-resistant prostate cancer cells, were used to investigate a possible novel treatment for castration-resistant prostate cancer. The PC3 cells were cultured and incubated with various concentrations of EPA or DHA...
August 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28776175/synthesis-and-identification-of-acedoxypc-a-protectin-containing-structured-phospholipid-using-liquid-chromatography-mass-spectrometry
#20
Amanda Lo Van, Baptiste Fourmaux, Madeleine Picq, Michel Guichardant, Michel Lagarde, Nathalie Bernoud-Hubac
Fatty acids have many health benefits in a great variety of diseases ranging from cardiovascular to cerebral diseases. For instance, docosahexaenoic acid (DHA), which is highly enriched in brain phospholipids, plays a major role in anti-inflammatory or neuroprotective pathways. Its effects are thought to be due, in part, to its conversion into derived mediators such as protectins. 1-Lyso,2-docosahexaenoyl-glycerophosphocholine (LysoPtdCho-DHA) is one of the physiological carrier of DHA to the brain. We previously synthesized a structured phosphatidylcholine to mimic 1-lyso,2-docosahexaenoyl-glycerophosphocholine, named AceDoPC(®) (1-acetyl,2-docosahexaenoyl-glycerophosphocholine), that is considered as a stabilized form of the physiological LysoPtdCho-DHA and that is neuroprotective in experimental ischemic stroke...
August 3, 2017: Lipids
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