Michael L Risner, Marcio Ribeiro, Nolan R McGrady, Bhanu S Kagitapalli, Xitiz Chamling, Donald J Zack, David J Calkins
BACKGROUND: Cell-to-cell communication is vital for tissues to respond, adapt, and thrive in the prevailing milieu. Several mechanisms mediate intercellular signaling, including tunneling nanotubes, gap junctions, and extracellular vesicles (EV). Depending on local and systemic conditions, EVs may contain cargoes that promote survival, neuroprotection, or pathology. Our understanding of pathologic intercellular signaling has been bolstered by disease models using neurons derived from human pluripotent stems cells (hPSC)...
October 30, 2023: Cell Communication and Signaling: CCS