Meng Fang, Hong-Kun Wu, Yumeng Pei, Yan Zhang, Xiangyu Gao, Yanyun He, Gengjia Chen, Fengxiang Lv, Peng Jiang, Yumei Li, Wenwen Li, Peng Jiang, Lin Wang, Jiafu Ji, Xinli Hu, Rui-Ping Xiao
Due to the essential role of cyclin D1 in regulating transition from G1 to S phase in cell cycle, aberrant cyclin D1 expression is a major oncogenic event in many types of cancers. In particular, the dysregulation of ubiquitination-dependent degradation of cyclin D1 contributes to not only the pathogenesis of malignancies but also the refractory to cancer treatment regiments with CDK4/6 inhibitors. Here we show that in colorectal and gastric cancer patients, MG53 is downregulated in more than 80% of tumors compared to the normal gastrointestinal tissues from the same patient, and the reduced MG53 expression is correlated with increased cyclin D1 abundance and inferior survival...
July 7, 2023: Signal Transduction and Targeted Therapy