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https://www.readbyqxmd.com/read/28640580/a-bio-inspired-alginate-gum-arabic-hydrogel-with-micro-nano-scale-structures-for-controlled-drug-release-in-chronic-wound-healing
#1
Mi Li, Haichang Li, Xiangguang Li, Hua Zhu, Zihui Xu, Lianqing Liu, Jianjie Ma, Mingjun Zhang
Bio-polymeric hydrogels have drawn increasingly research interests in biomaterials due to its tunable physical and chemical properties for both creating bioactive cellular micro-environment and serving as sustainable therapeutic reagents. Inspired by a naturally occurring hydrogel secreted from the carnivorous Sundew plant for trapping insects, here we have developed a bio-inspired hydrogel to deliver mitsugumin53 (MG53), an important protein in cell membrane repair, for chronic wound healing. Both chemical compositions and micro/nano morphological properties inherent from the natural Sundew hydrogel were mimicked using sodium alginate and gum arabic with calcium ion-mediated cross-linking...
June 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28498861/modulation-of-caveolins-integrins-and-plasma-membrane-repair-proteins-in-anthracycline-induced-heart-failure-in-rabbits
#2
Yasuhiro Ichikawa, Alice E Zemljic-Harpf, Zheng Zhang, M Dan McKirnan, Ana Maria Manso, Robert S Ross, H Kirk Hammond, Hemal H Patel, David M Roth
Anthracyclines are chemotherapeutic drugs known to induce heart failure in a dose-dependent manner. Mechanisms involved in anthracycline cardiotoxicity are an area of relevant investigation. Caveolins bind, organize and regulate receptors and signaling molecules within cell membranes. Caveolin-3 (Cav-3), integrins and related membrane repair proteins can function as cardioprotective proteins. Expression of these proteins in anthracycline-induced heart failure has not been evaluated. We tested the hypothesis that daunorubicin alters cardioprotective protein expression in the heart...
2017: PloS One
https://www.readbyqxmd.com/read/28432201/mg53-biological-function-and-potential-as-a-therapeutic-target
#3
Yan Zhang, Hong-Kun Wu, Fengxiang Lv, Rui-Ping Xiao
MG53 (also known as TRIM72) is a cardiac and skeletal muscle-specific TRIM-family protein that exhibits multiple biological functions. First, MG53 participates in plasma membrane repair of the heart, skeletal muscle and other tissues. Second, MG53 is essentially involved in the cardioprotection of cardiac ischemic, pre-conditioning and post-conditioning, by activating the PI3K-Akt-GSK3β and ERK1/2 survival signaling pathways. Moreover, systemic delivery of recombinant MG53 protein ameliorates the impact of a range of injury insults on heart, skeletal muscle, lung, kidney, skin and brain...
April 21, 2017: Molecular Pharmacology
https://www.readbyqxmd.com/read/28401647/mg53-anchored-by-dysferlin-to-cell-membrane-reduces-hepatocyte-apoptosis-which-induced-by-ischaemia-reperfusion-injury-in%C3%A2-vivo-and-in%C3%A2-vitro
#4
Weifeng Yao, Haobo Li, Xue Han, Chaojin Chen, Yihan Zhang, Wai Lydia Tai, Zhengyuan Xia, Ziqing Hei
Hepatic ischaemia/reperfusion (HIR) induces severe damage on hepatocyte cell membrane, which leads to hepatocyte death and the subsequent HIR injury. In this study, we investigated the role and the mechanism of mitsugumin-53 (MG53), a novel cell membrane repair protein, in protecting the liver against HIR injury. Rats were subjected to sham operation or 70% warm HIR with or without recombined MG53 (rhMG53), caudal vein-injected 2 hrs before inducing HIR. In vitro, cultured hepatocyte AML12 cells were subjected to hypoxia/reoxygenation (H/R) in the presence of rhMG53 and/or dysferlin gene shRNAs or adenovirus transfection...
April 12, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27810898/mg53-irs-1-mitsugumin-53-insulin-receptor-substrate-1-interaction-disruptor-sensitizes-insulin-signaling-in-skeletal-muscle
#5
Hyun Lee, Jung-Jin Park, Nga Nguyen, Jun Sub Park, Jin Hong, Seung-Hyeob Kim, Woon Young Song, Hak Joong Kim, Kwangman Choi, Sungchan Cho, Jae-Seon Lee, Bong-Woo Kim, Young-Gyu Ko
Mitsugumin 53 (MG53) is an E3 ligase that interacts with and ubiquitinates insulin receptor substrate-1 (IRS-1) in skeletal muscle; thus, an MG53-IRS-1 interaction disruptor (MID), which potentially sensitizes insulin signaling with an elevated level of IRS-1 in skeletal muscle, is an excellent candidate for treating insulin resistance. To screen for an MID, we developed a bimolecular luminescence complementation system using an N-terminal luciferase fragment fused with IRS-1 and a C-terminal luciferase fragment fused with an MG53 C14A mutant that binds to IRS-1 but does not have E3 ligase activity...
December 23, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27559699/hypercholesterolemia-abrogates-remote-ischemic-preconditioning-induced-cardioprotection-role-of-reperfusion-injury-salvage-kinase-signals
#6
Lei-Lei Ma, Fei-Juan Kong, Jun-Jie Guo, Jian-Bing Zhu, Hong-Tao Shi, Yang Li, Ren-Hua Sun, Jun-Bo Ge
Remote ischemic preconditioning (RIPC) is one of the most powerful intrinsic cardioprotective strategies discovered so far and experimental data indicate that comorbidity may interfere with the protection by RIPC. Therefore, we investigate whether RIPC-induced cardioprotection was intact in hypercholesterolemic rat hearts exposed to ischemia reperfusion in vivo. Normal or hypercholesterolemic rat hearts were exposed to 30 min of ischemia and 2 h of reperfusion, with or without RIPC, PI3K inhibitor wortmannin, MEK-ERK1/2 inhibitor PD98059, GSK3β inhibitor SB216763...
March 2017: Shock
https://www.readbyqxmd.com/read/27546510/mg53-is-a-double-edged-sword-for-human-diseases
#7
REVIEW
Yan Zhang, Hong-Kun Wu, Feng-Xiang Lv, Rui-Ping Xiao
Mitsugumin 53 (MG53), also named Trim72, is a multi-functional TRIM-family protein, which is abundantly expressed in cardiac and skeletal muscle. It has been shown that MG53 not only plays important physiological roles but also acts as a crucial pathogenic factor of various diseases. First, MG53 preserves cardiac and skeletal muscle integrity via facilitating plasma membrane repair. Second, MG53 is essentially involved in cardiac ischemic preconditioning and postconditioning by activating PI3K-Akt-GSK3β and ERK1/2 cell survival signaling pathways...
August 25, 2016: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/27545095/a-novel-perspective-for-burn-induced-myopathy-membrane-repair-defect
#8
Chao Wang, Hongyu Wang, Dan Wu, Jianhong Hu, Wei Wu, Yong Zhang, Xi Peng
Myopathy is a common complication of severe burn patients. One potential cause of this myopathy could be failure of the plasma membrane to undergo repair following injuries generated from toxin or exercise. The aim of this study is to assess systemic effect on muscle membrane repair deficiency in burn injury. Skeletal muscle fibers isolated from burn-injured mice were damaged with a UV laser and dye influx imaged confocally to evaluate membrane repair capacity. Membrane repair failure was also tested in burn-injured mice subjected to myotoxin or treadmill exercise...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27534381/age-related-alterations-in-the-sarcolemmal-environment-are-attenuated-by-lifelong-caloric-restriction-and-voluntary-exercise
#9
Jeffrey M Hord, Rachel Botchlett, John M Lawler
Age-related loss of skeletal muscle mass and function, referred to as sarcopenia, is mitigated by lifelong calorie restriction as well as exercise. In aged skeletal muscle fibers there is compromised integrity of the cell membrane that may contribute to sarcopenia. The purpose of this study was to determine if lifelong mild (8%) caloric restriction (CR) and lifelong CR+voluntary wheel running (WR) could ameliorate disruption of membrane scaffolding and signaling proteins during the aging process, thus maintaining a favorable, healthy membrane environment in plantaris muscle fibers...
October 2016: Experimental Gerontology
https://www.readbyqxmd.com/read/27298325/an-actin-dependent-annexin-complex-mediates-plasma-membrane-repair-in-muscle
#10
Alexis R Demonbreun, Mattia Quattrocelli, David Y Barefield, Madison V Allen, Kaitlin E Swanson, Elizabeth M McNally
Disruption of the plasma membrane often accompanies cellular injury, and in muscle, plasma membrane resealing is essential for efficient recovery from injury. Muscle contraction, especially of lengthened muscle, disrupts the sarcolemma. To define the molecular machinery that directs repair, we applied laser wounding to live mammalian myofibers and assessed translocation of fluorescently tagged proteins using high-resolution microscopy. Within seconds of membrane disruption, annexins A1, A2, A5, and A6 formed a tight repair "cap...
June 20, 2016: Journal of Cell Biology
https://www.readbyqxmd.com/read/27174502/dual-function-of-mg53-in-membrane-repair-and-insulin-signaling
#11
REVIEW
Tao Tan, Young-Gyu Ko, Jianjie Ma
MG53 is a member of the TRIM-family protein that acts as a key component of the cell membrane repair machinery. MG53 is also an E3-ligase that ubiquinates insulin receptor substrate-1 and controls insulin signaling in skeletal muscle cells. Since its discovery in 2009, research efforts have been devoted to translate this basic discovery into clinical applications in human degenerative and metabolic diseases. This review article highlights the dual function of MG53 in cell membrane repair and insulin signaling, the mechanism that underlies the control of MG53 function, and the therapeutic value of targeting MG53 function in regenerative medicine...
August 2016: BMB Reports
https://www.readbyqxmd.com/read/27034027/myosin-heavy-chain-is-stabilized-by-bcl-2-interacting-cell-death-suppressor-bis-in-skeletal-muscle
#12
Jin Hong, Jun-Sub Park, Hyun Lee, Jaemin Jeong, Hye Hyeon Yun, Hye Yun Kim, Young-Gyu Ko, Jeong-Hwa Lee
BCL-2 interacting cell death suppressor (BIS), which is ubiquitously expressed, has important roles in various cellular processes, such as apoptosis, the cellular stress response, migration and invasion and protein quality control. In particular, BIS is highly expressed in skeletal and cardiac muscles, and BIS gene mutations result in human myopathy. In this study, we show that mRNA and protein levels of BIS were markedly increased during skeletal myogenesis in C2C12 cells and mouse satellite cells. BIS knockdown did not prevent the early stage of skeletal myogenesis, but did induce muscle atrophy and a decrease in the diameter of myotubes...
April 1, 2016: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/26985866/tripartite-motif-protein-72-regulates-the-proliferation-and-migration-of-rat-cardiac-fibroblasts-via-the-transforming-growth-factor-%C3%AE-signaling-pathway
#13
Jianquan Zhao, Han Lei
BACKGROUND: The proliferation and migration of cardiac fibroblasts are critical for the progress of cardiac fibrosis. Tripartite motif protein 72 (Trim72), also known as MG53, mediates the dynamic process of membrane fusion and exocytosis in striated muscle. However, the role of Trim72 in the proliferation and migration of cardiac fibroblasts is unknown. METHODS: In the present study, we used small interference RNA (siRNA) to silence Trim72 and then investigated the effects of Trim72 on cardiac fibroblast proliferation and migration, which were activated during cardiac remodeling after myocardial infarction...
2016: Cardiology
https://www.readbyqxmd.com/read/26967557/mg53-permeates-through-blood-brain-barrier-to-protect-ischemic-brain-injury
#14
Yonggang Yao, Bo Zhang, Hua Zhu, Haichang Li, Yu Han, Ken Chen, Zhen Wang, Jing Zeng, Yukai Liu, Xinquan Wang, Yu Li, Duofen He, Peihui Lin, Xinyu Zhou, Ki Ho Park, Zehua Bian, Zhishui Chen, Nianqiao Gong, Tao Tan, Jingsong Zhou, Meng Zhang, Jianjie Ma, Chunyu Zeng
Ischemic injury to neurons represents the underlying cause of stroke to the brain. Our previous studies identified MG53 as an essential component of the cell membrane repair machinery. Here we show that the recombinant human (rh)MG53 protein facilitates repair of ischemia-reperfusion (IR) injury to the brain. MG53 rapidly moves to acute injury sites on neuronal cells to form a membrane repair patch. IR-induced brain injury increases permeability of the blood-brain-barrier, providing access of MG53 from blood circulation to target the injured brain tissues...
April 19, 2016: Oncotarget
https://www.readbyqxmd.com/read/26790476/lack-of-mg53-in-human-heart-precludes-utility-as-a-biomarker-of-myocardial-injury-or-endogenous-cardioprotective-factor
#15
Frances A Lemckert, Adam Bournazos, Daniel M Eckert, Manuel Kenzler, Joanne M Hawkes, Tanya L Butler, Bradley Ceely, Kathryn N North, David S Winlaw, Jonathan R Egan, Sandra T Cooper
AIMS: Mitsugumin-53 (MG53/TRIM72) is an E3-ubiquitin ligase that rapidly accumulates at sites of membrane injury and plays an important role in membrane repair of skeletal and cardiac muscle. MG53 has been implicated in cardiac ischaemia-reperfusion injury, and serum MG53 provides a biomarker of skeletal muscle injury in the mdx mouse model of Duchenne muscular dystrophy. We evaluated the clinical utility of MG53 as a biomarker of myocardial injury. METHODS AND RESULTS: We performed Langendorff ischaemia-reperfusion injury on wild-type and dysferlin-null murine hearts, using dysferlin deficiency to effectively model more severe outcomes from cardiac ischaemia-reperfusion injury...
May 15, 2016: Cardiovascular Research
https://www.readbyqxmd.com/read/26781830/plasma-membrane-repair-in%C3%A2-health-and-disease
#16
REVIEW
Alexis R Demonbreun, Elizabeth M McNally
Since an intact membrane is required for normal cellular homeostasis, membrane repair is essential for cell survival. Human genetic studies, combined with the development of novel animal models and refinement of techniques to study cellular injury, have now uncovered series of repair proteins highly relevant for human health. Many of the deficient repair pathways manifest in skeletal muscle, where defective repair processes result in myopathies or other forms of muscle disease. Dysferlin is a membrane-associated protein implicated in sarcolemmal repair and also linked to other membrane functions including the maintenance of transverse tubules in muscle...
2016: Current Topics in Membranes
https://www.readbyqxmd.com/read/26306047/modulation-of-wound-healing-and-scar-formation-by-mg53-protein-mediated-cell-membrane-repair
#17
Haichang Li, Pu Duann, Pei-Hui Lin, Li Zhao, Zhaobo Fan, Tao Tan, Xinyu Zhou, Mingzhai Sun, Minghuan Fu, Matthew Orange, Matthew Sermersheim, Hanley Ma, Duofen He, Steven M Steinberg, Robert Higgins, Hua Zhu, Elizabeth John, Chunyu Zeng, Jianjun Guan, Jianjie Ma
Cell membrane repair is an important aspect of physiology, and disruption of this process can result in pathophysiology in a number of different tissues, including wound healing, chronic ulcer and scarring. We have previously identified a novel tripartite motif family protein, MG53, as an essential component of the cell membrane repair machinery. Here we report the functional role of MG53 in the modulation of wound healing and scarring. Although MG53 is absent from keratinocytes and fibroblasts, remarkable defects in skin architecture and collagen overproduction are observed in mg53(-/-) mice, and these animals display delayed wound healing and abnormal scarring...
October 2, 2015: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/25950605/effect-of-metabolic-syndrome-on-mitsugumin-53-expression-and-function
#18
Hanley Ma, Jason Liu, Zehua Bian, Yuqi Cui, Xinyu Zhou, Xuefeng Zhou, Bo Zhang, T M Ayodele Adesanya, Frank Yi, Ki Ho Park, Tao Tan, Zhishui Chen, Hua Zhu
Metabolic syndrome is a cluster of risk factors, such as obesity, insulin resistance, and hyperlipidemia that increases the individual's likelihood of developing cardiovascular diseases. Patients inflicted with metabolic disorders also suffer from tissue repair defect. Mitsugumin 53 (MG53) is a protein essential to cellular membrane repair. It facilitates the nucleation of intracellular vesicles to sites of membrane disruption to create repair patches, contributing to the regenerative capacity of skeletal and cardiac muscle tissues upon injury...
2015: PloS One
https://www.readbyqxmd.com/read/25869134/zinc-binding-to-mg53-protein-facilitates-repair-of-injury-to-cell-membranes
#19
Chuanxi Cai, Peihui Lin, Hua Zhu, Jae-Kyun Ko, Moonsun Hwang, Tao Tan, Zui Pan, Irina Korichneva, Jianjie Ma
Zinc is an essential trace element that participates in a wide range of biological functions, including wound healing. Although Zn(2+) deficiency has been linked to compromised wound healing and tissue repair in human diseases, the molecular mechanisms underlying Zn(2+)-mediated tissue repair remain unknown. Our previous studies established that MG53, a TRIM (tripartite motif) family protein, is an essential component of the cell membrane repair machinery. Domain homology analysis revealed that MG53 contains two Zn(2+)-binding motifs...
May 29, 2015: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/25787762/mg53-mediated-cell-membrane-repair-protects-against-acute-kidney-injury
#20
Pu Duann, Haichang Li, Peihui Lin, Tao Tan, Zhen Wang, Ken Chen, Xinyu Zhou, Kristyn Gumpper, Hua Zhu, Thomas Ludwig, Peter J Mohler, Brad Rovin, William T Abraham, Chunyu Zeng, Jianjie Ma
Injury to the renal proximal tubular epithelium (PTE) represents the underlying consequence of acute kidney injury (AKI) after exposure to various stressors, including nephrotoxins and ischemia/reperfusion (I/R). Although the kidney has the ability to repair itself after mild injury, insufficient repair of PTE cells may trigger inflammatory and fibrotic responses, leading to chronic renal failure. We report that MG53, a member of the TRIM family of proteins, participates in repair of injured PTE cells and protects against the development of AKI...
March 18, 2015: Science Translational Medicine
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