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https://www.readbyqxmd.com/read/28427294/increased-phagocytic-nadph-oxidase-activity-associates-with-coronary-artery-calcification-in-asymptomatic-men
#1
Oscar Beloqui, María U Moreno, Gorka San José, Álvaro Pejenaute, Adriana Cortés, Manuel F Landecho, Javier Díez, Ana Fortuño, Guillermo Zalba
Vascular calcification is a common feature in atherosclerosis and associates with cardiovascular events. Oxidative stress may be involved in the pathogenesis of vascular calcification. Previous studies have shown that the phagocytic NADPH oxidase is associated with atherosclerosis. The objective of the present study was to investigate the association between phagocytic NADPH oxidase-mediated superoxide production and coronary artery calcium (CAC). NADPH oxidase-mediated superoxide production was determined by chemiluminescence and CAC by computed tomography in 159 asymptomatic men free of overt clinical atherosclerosis...
April 20, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28420590/volume-and-dimensions-of-angiographically-normal-coronary-arteries-assessed-by-multidetector-computed-tomography
#2
Samuel Kiil Sørensen, Jørgen Tobias Kühl, Andreas Fuchs, Jakob Boesgaard Norsk, Lars Valeur Køber, Børge Grønne Nordestgaard, Klaus Fuglsang Kofoed
BACKGROUND: The objective of this study was to determine normal values for coronary artery volume (CAV) and individual vasculature and segment dimensions. METHODS: We examined 200 healthy volunteers with an Agatston score of 0 and a normal, high quality coronary CTA. Using 320 slice multidetector row CT and designated vessel tracing software with border detection algorithm, the main coronary arteries and branches were delineated and total and segmental dimensions calculated...
April 4, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28413071/performance-of-ultra-low-dose-ct-for-the-evaluation-of-coronary-calcification-a-direct-comparison-with-coronary-calcium-score
#3
V V Silveira de Souza, F Soares Torres, B Hochhegger, G Watte, G Sartori, F Lucchese, B Azambuja Gonçalves
AIM: To evaluate the diagnostic performance of ultra-low-dose computed tomography (ULDCT) in comparison to standard coronary calcium score (CCS) acquisition for the evaluation of coronary artery calcification (CAC). MATERIALS AND METHODS: Standard CCS acquisition and ULDCT were performed in patients referred for coronary CT angiography for the evaluation of coronary artery disease. CAC in ULDCT was graded subjectively using a four-point scale (from 0, no calcification, to 3, severe calcification) for the complete study and for each individual coronary segment...
April 13, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28411031/prognostic-value-of-visually-detected-coronary-artery-calcification-on-unenhanced-non-gated-thoracic-computed-tomography-for-prediction-of-non-fatal-myocardial-infarction-and-all-cause-mortality
#4
Lisa Shao, Andrew T Yan, Gerald Lebovic, Harvey H Wong, Anish Kirpalani, Djeven P Deva
PURPOSE: To determine the prognostic value of visually detected coronary artery calcification (CAC) on unenhanced non-gated thoracic computed tomography (CT) for non-fatal myocardial infarction (MI) and all-cause mortality. METHODS: This retrospective single-centre cohort study comprised of 410 consecutive patients aged 40-80 years without any known cardiovascular disease at baseline. CT images without electrocardiogram-gating were acquired for a variety of respiratory medicine indications...
March 28, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28395916/strengths-and-limitations-of-coronary-angiography-with-turbo-high-pitch-third-generation-dual-source-ct
#5
M M Ochs, F Andre, G Korosoglou, T Fritz, S Seitz, Y Bogomazov, C L Schlett, R Sokiranski, A Sommer, F Gückel, M Brado, H-U Kauczor, J Görich, H A Katus, S J Buss
AIM: To define practical limitations of diagnostic image quality for recently introduced turbo high-pitch scan mode (THP) in third-generation dual-source computed tomography (CT). MATERIALS AND METHODS: Two hundred and twenty-nine consecutive patients undergoing CT coronary angiography were included in this retrospective single-centre analysis. A contrast-enhanced volume dataset was acquired in THP. Image quality of coronary segments was classified as diagnostic or non-diagnostic by three blinded readers...
April 8, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28392544/impact-of-renal-functional-morphological-dynamics-on-the-calcification-of-coronary-and-abdominal-arteries-in-patients-with-chronic-kidney-disease
#6
Takeo Ichii, Ryota Morimoto, Takahiro Okumura, Hideki Ishii, Yosuke Tatami, Dai Yamamoto, Soichiro Aoki, Hiroaki Hiraiwa, Kenji Furusawa, Toru Kondo, Naoki Watanabe, Naoaki Kano, Kenji Fukaya, Akinori Sawamura, Susumu Suzuki, Yoshinari Yasuda, Toyoaki Murohara
AIM: Fast-progressing vascular calcification (VC) is accompanied by renal atrophy and functional deterioration along with atherosclerosis in patients with chronic kidney disease (CKD). However, the relationship between VC progression and renal functional and/or morphological changes remains unclear. METHODS: We included 70 asymptomatic patients with CKD without hemodialysis in our study. To identify temporal variations, the coronary artery calcification score (CACS), abdominal aortic calcification index (ACI), and renal parenchymal volume index (RPVI) were determined via spiral computed tomography scans taken during the study...
April 8, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28388944/renal-function-had-an-independent-relationship-with-coronary-artery-calcification-in-chinese-elderly-men
#7
Shihui Fu, Zhao Zhang, Leiming Luo, Ping Ye
BACKGROUND: Although previous studies have analyzed the relationship between renal function and coronary artery calcification (CAC) in pre-dialysis and dialysis patients, limited studies have discussed the relationship between renal function and CAC in Chinese elderly men without obvious damage of renal function. The present study was designed to explore the relationship between renal function and CAC in Chinese elderly men without obvious damage of renal function. METHODS: This cross-sectional study was carried out in 105 male participants older than 60 years with glomerular filtration rate (GFR) ≥ 45 ml/min/1...
April 7, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28378112/automatic-determination-of-cardiovascular-risk-by-ct-attenuation-correction-maps-in-rb-82-pet-ct
#8
Ivana Išgum, Bob D de Vos, Jelmer M Wolterink, Damini Dey, Daniel S Berman, Mathieu Rubeaux, Tim Leiner, Piotr J Slomka
BACKGROUND: We investigated fully automatic coronary artery calcium (CAC) scoring and cardiovascular disease (CVD) risk categorization from CT attenuation correction (CTAC) acquired at rest and stress during cardiac PET/CT and compared it with manual annotations in CTAC and with dedicated calcium scoring CT (CSCT). METHODS AND RESULTS: We included 133 consecutive patients undergoing myocardial perfusion (82)Rb PET/CT with the acquisition of low-dose CTAC at rest and stress...
April 4, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28369281/relation-between-calcium-burden-echocardiographic-stent-frame-eccentricity-and-paravalvular-leakage-after-corevalve-transcatheter-aortic-valve-implantation
#9
Luigi F M Di Martino, Osama I I Soliman, Lennart van Gils, Wim B Vletter, Nicolas M Van Mieghem, Ben Ren, Tjebbe W Galema, Carl Schultz, Peter P T de Jaegere, Matteo Di Biase, Marcel L Geleijnse
Aims: Paravalvular aortic leakage (PVL) after transcatheter aortic valve implantation (TAVI) is a complication with potentially severe consequences. The relation between native aortic root calcium burden, stent frame eccentricity and PVL was not studied before. Methods and results: Two-hundred-and-twenty-three consecutive patients with severe aortic stenosis who underwent TAVI with a Medtronic CoreValve System© and who had available pre-discharge transthoracic echocardiography were studied...
March 27, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28361742/coffee-consumption-and-calcified-atherosclerotic-plaques-in-the-coronary-arteries-the-nhlbi-family-heart-study
#10
Yash R Patel, Taraka V Gadiraju, R Curtis Ellison, Steven C Hunt, John Jeffrey Carr, Gerardo Heiss, Donna K Arnett, James S Pankow, J Michael Gaziano, Luc Djoussé
BACKGROUND & AIMS: While a recent meta-analysis of prospective studies reported that coffee consumption is associated with a lower risk of cardiovascular disease mortality, limited and inconsistent data are available on the relation of coffee intake with subclinical disease. Thus, the aim of the present study was to see the association of coffee consumption with the prevalence of atherosclerotic plaque in the coronary arteries in NHLBI Family Heart Study. METHODS: In a cross-sectional design, we studied 1929 participants of the NHLBI Family Heart Study without known coronary heart disease...
February 2017: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28349280/quantification-of-temporal-changes-in-calcium-score-in-active-atherosclerotic-plaque-in-major-vessels-by-18-f-sodium-fluoride-pet-ct
#11
Yoshinobu Ishiwata, Tomohiro Kaneta, Shintaro Nawata, Ayako Hino-Shishikura, Keisuke Yoshida, Tomio Inoue
PURPOSE: Our aim was to assess whether (18)F-NaF PET/CT is able to predict progression of the CT calcium score. METHODS: Between August 2007 and November 2015, 34 patients (18 women, 16 men; age, mean ± standard deviation, 57.5 ± 13.9 years; age range 19-78 years) with malignancy or orthopaedic disease were enrolled in this study, with approximately 1-year follow-up data. Baseline and follow-up CT images were retrospectively evaluated for the presence of calcification sites in major vessel walls...
March 27, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28324126/relationship-between-cardiac-calcification-and-left-ventricular-hypertrophy-in-patients-with-chronic-kidney-disease-at-hemodialysis-initiation
#12
Ken Kitamura, Hideki Fujii, Kentaro Nakai, Keiji Kono, Shunsuke Goto, Tatsuya Nishii, Atsushi Kono, Shinichi Nishi
Coronary artery calcification (CAC), cardiac valve calcification (CVC) and left ventricular hypertrophy (LVH) are frequently observed in chronic kidney disease (CKD) patients. These abnormalities significantly affect morbidity and mortality. The aim of this study was to investigate the relationship between CAC, CVC and LVH in CKD patients. This study included 96 patients who were hospitalized and initiated hemodialysis between December 2011 and July 2014 at our five institutions. Multi-detector computed tomography for the quantification of CAC using the Agatston score and transthoracic echocardiography for assessing CVC and LVH were performed for all patients included in the study...
March 21, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28302634/residential-proximity-to-major-roads-exposure-to-fine-particulate-matter-and-aortic-calcium-the-framingham-heart-study-a-cohort-study
#13
Kirsten S Dorans, Elissa H Wilker, Wenyuan Li, Mary B Rice, Petter L Ljungman, Joel Schwartz, Brent A Coull, Itai Kloog, Petros Koutrakis, Ralph B D'Agostino, Joseph M Massaro, Udo Hoffmann, Christopher J O'Donnell, Murray A Mittleman
OBJECTIVES: Traffic and ambient air pollution exposure are positively associated with cardiovascular disease, potentially through atherosclerosis promotion. Few studies have assessed associations of these exposures with thoracic aortic calcium Agatston score (TAC) or abdominal aortic calcium Agatston score (AAC), systemic atherosclerosis correlates. We assessed whether living close to a major road and residential fine particulate matter (PM2.5) exposure were associated with TAC and AAC in a Northeastern US cohort...
March 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/28283359/impact-of-filter-convolution-and-displayed-field-of-view-on-estimation-of-coronary-agatston-scores-in-low-dose-lung-computed-tomography
#14
Yung-Liang Wan, Pei-Kwei Tsay, Patricia Wanping Wu, Yu-Hsiang Juan, Hui-Yu Tsai, Chung-Yin Lin, Chih-Sheng Yeh, Chun-Hua Wang, Chun-Chi Chen
BACKGROUND: Coronary artery calcification (CAC) may be quantified on low-dose computed tomography (CT) of the lung (LDCT). This study aims to evaluate the effects of filter convolution (FC) and displayed field of view (dFOV) in a Toshiba 320-row CT scanner in quantifying CAC, and to compare the CAC scores obtained by LDCT with standard cardiac CT. METHODS: Fifty subjects (52 to 85years, mean 68.5, 36 males) with visible CAC underwent both standard cardiac CT and LDCT...
February 27, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28281025/ct-myocardial-perfusion-imaging-current-status-and-future-perspectives
#15
Dong Hyun Yang, Young-Hak Kim
Computed tomography myocardial perfusion (CTP) combined with coronary computed tomography angiography (CCTA) may constitute a "1-stop shop" for the noninvasive diagnosis of hemodynamically significant coronary stenosis during a single CT examination. CTP shows high diagnostic performance and provides incremental value over CCTA for the detection of hemodynamically significant coronary stenosis in patients with a high Agatston calcium score or coronary artery stents. Future studies should determine the optimal protocol and clinical value of CTP for guiding revascularization strategy and prognostication...
March 9, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28275938/role-of-coronary-calcium-for-risk-stratification-and-prognostication
#16
REVIEW
Negin Nezarat, Michael Kim, Matthew Budoff
A multitude of studies now support the understanding that an increased coronary artery calcium (CAC) score represents advanced atherosclerosis and high risk for cardiovascular disease (CVD) and, as such, should be treated with conventional therapies for those considered high risk. Data is now available to guide treatment with aspirin, statins, and lifestyle management. The new ACC/AHA 2013 guidelines support intensifying statin therapy when the CAC is ≥75th percentile for age, sex, and ethnicity/race or when the calcium score is ≥300 Agatston units...
February 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28260958/sleep-apnea-risk-and-subclinical-atherosclerosis-in-early-middle-aged-retired-national-football-league-players
#17
Faith S Luyster, Reginald E Dunn, Diane S Lauderdale, Mercedes R Carnethon, Andrew M Tucker, Robert A Vogel, Andrew E Lincoln, Kristen L Knutson, Elliot J Pellman, Patrick J Strollo
PURPOSE: Limited data from former National Football League (NFL) players suggest that obstructive sleep apnea (OSA) may be highly prevalent after retirement. It remains unclear whether the high prevalence of OSA in retired players is comparable to nonathletes. This retrospective analysis compared sleep apnea (SA) risk in retired NFL players to a community cohort (CARDIA Sleep study), and examined associations between SA risk and cardiovascular risk factors, including subclinical atherosclerosis...
2017: Nature and Science of Sleep
https://www.readbyqxmd.com/read/28257295/coronary-artery-calcification-detection-with-invasive-coronary-angiography-in-comparison-with-unenhanced-computed-tomography
#18
Joris D van Dijk, Mohammad S Shams, Jan Paul Ottervanger, Mohamed Mouden, Jorn A van Dalen, Pieter L Jager
OBJECTIVE: The presence of extensive coronary artery calcifications (CAC) influences treatment decisions, particularly for revascularization. However, important CAC might be missed with invasive coronary angiography (ICA). Our aim was to determine the accuracy of ICA in the identification of CAC using computed tomography (CT) as reference standard. PATIENTS AND METHODS: Overall, 349 consecutive patients who underwent both CT-based CAC-scoring and invasive coronary angiography within 60 days were retrospectively included...
May 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28241355/testosterone-treatment-and-coronary-artery-plaque-volume-in-older-men-with-low-testosterone
#19
RANDOMIZED CONTROLLED TRIAL
Matthew J Budoff, Susan S Ellenberg, Cora E Lewis, Emile R Mohler, Nanette K Wenger, Shalender Bhasin, Elizabeth Barrett-Connor, Ronald S Swerdloff, Alisa Stephens-Shields, Jane A Cauley, Jill P Crandall, Glenn R Cunningham, Kristine E Ensrud, Thomas M Gill, Alvin M Matsumoto, Mark E Molitch, Rine Nakanishi, Negin Nezarat, Suguru Matsumoto, Xiaoling Hou, Shehzad Basaria, Susan J Diem, Christina Wang, Denise Cifelli, Peter J Snyder
Importance: Recent studies have yielded conflicting results as to whether testosterone treatment increases cardiovascular risk. Objective: To test the hypothesis that testosterone treatment of older men with low testosterone slows progression of noncalcified coronary artery plaque volume. Design, Setting, and Participants: Double-blinded, placebo-controlled trial at 9 academic medical centers in the United States. The participants were 170 of 788 men aged 65 years or older with an average of 2 serum testosterone levels lower than 275 ng/dL (82 men assigned to placebo, 88 to testosterone) and symptoms suggestive of hypogonadism who were enrolled in the Testosterone Trials between June 24, 2010, and June 9, 2014...
February 21, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28240378/coronary-artery-calcification-and-cognitive-function-cross-sectional-results-from-the-elsa-brasil-study
#20
Claudia K Suemoto, Marcio S Bittencourt, Itamar S Santos, Isabela M Benseñor, Paulo A Lotufo
OBJECTIVES: We examined the relationship between coronary artery calcification (CAC) score and performance in cognitive tests in a large Brazilian sample. METHODS: In this cross-sectional study, 4104 participants (mean age = 50.9 ± 8.8 years old, 54% female) from the Brazilian Longitudinal Study of Adult Health had complete information for CAC and cognitive tests. We used linear regression models adjusted for sociodemographics, cardiovascular risk factors (hypertension, diabetes, smoking, alcohol use, physical activity, and body mass index), depression, and thyroid function...
February 27, 2017: International Journal of Geriatric Psychiatry
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