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Agatston score

Takayoshi Yamaguchi, Katsuhiro Ichikawa, Daichi Takahashi, Teppei Sugaya, Jungo Furuya, Keiichi Igarashi
RATIONALE AND OBJECTIVES: We have developed a new contrast enhancement protocol for subtraction coronary computed tomography (SCCTA) requiring a short breath-holding time. In the protocol, test and main boluses were sequentially and automatically injected, and correct timings for pre-contrast and contrast-enhanced scans for main bolus were automatically determined only by the test bolus tracking. Combined with a fixed short main bolus injection for 7 seconds, the breath-holding time was shortened as possible...
October 17, 2016: Academic Radiology
Lea Azour, Michael A Kadoch, Thomas J Ward, Corey D Eber, Adam H Jacobi
BACKGROUND: Coronary artery calcium (CAC) is often identified on routine chest computed tomography (CT). The purpose of our study was to evaluate whether ordinal scoring of CAC on non-gated, routine chest CT is an accurate predictor of Agatston score ranges in a community-based population, and in particular to determine the accuracy of an ordinal score of zero on routine chest CT. METHODS: Two thoracic radiologists reviewed consecutive same-day ECG-gated and routine non-gated chest CT scans of 222 individuals...
October 5, 2016: Journal of Cardiovascular Computed Tomography
Michael Messerli, Fabian Rengier, Lotus Desbiolles, Niklas F Ehl, Ralf W Bauer, Sebastian Leschka, Hatem Alkadhi, Simon Wildermuth, Claas P Nähle
RATIONALE AND OBJECTIVES: To evaluate the influence of advanced modeled iterative reconstruction (ADMIRE) on the coronary artery calcium (CAC) scores by computed tomography (CT). MATERIALS AND METHODS: Sixty patients underwent CAC imaging with dual-source 192-slice CT. Agatston, volume and mass score were calculated from filtered back projection (FBP) and iterative reconstructions with different levels of ADMIRE. Friedman test and Wilcoxon rank sum test were used for multiple comparisons of CAC values and the difference ratio among different ADMIRE groups using FBP as reference...
October 11, 2016: Academic Radiology
Eunjin Bae, Eun Yong Seong, Byoung-Geun Han, Dong Ki Kim, Chun Soo Lim, Shin-Wook Kang, Cheol Whee Park, Chan-Duck Kim, Byung Chul Shin, Sung Gyun Kim, Wookyung Chung, Jae Yoon Park, Joo Yeon Lee, Yon Su Kim
Introduction Patients with chronic kidney disease have an extremely high risk of developing cardiovascular disease (CVD). In patients with end-stage renal disease (ESRD), coronary artery calcification (CAC) is associated with increased mortality from CVD. Methods The present study aimed to investigate the risk factors for CAC in Korean patients with incident dialysis. Data on 423 patients with ESRD who started dialysis therapy between December 2012 and March 2014 were obtained from 10 university-affiliated hospitals...
October 5, 2016: Hemodialysis International
Hwa Seon Shin, Mi Jung Park, Kyung Nyeo Jeon, Jae Min Cho, Kyung Soo Bae, Dae Seob Choi, Jae Boem Na, Ho Cheol Choi, Hye Young Choi, Ji Eun Kim, Soo Bueum Cho, Sung Eun Park
BACKGROUND: Until now, there has been no study on the relationship between the calcification of the lower extremity arteries and significant coronary arterial disease (CAD). OBJECTIVES: To evaluate whether lower extremity calcium scores (LECS) are associated with CAD and whether this can predict multivessel-CAD in patients with peripheral arterial disease (PAD). PATIENTS AND METHODS: We retrospectively enrolled 103 PAD patients without cardiac symptoms or known CAD...
April 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
Iván Ferraz-Amaro, Robert Winchester, Peter K Gregersen, Richard J Reynolds, Mary Chester Wasko, Anette Oeser, Cecilia P Chung, C Michael Stein, Jon T Giles, Joan M Bathon
OBJECTIVE: Coronary artery disease (CAD) in the general population is characterized by an increased frequency of particular susceptibility single nucleotide polymorphisms (SNPs). Since CAD is increased in rheumatoid arthritis (RA), we sought to determine whether the frequency of these SNPs are increased in RA patients with CAD, hypothesizing that RA could enhance CAD risk by acting through established genetic pathways predisposing to CAD. METHODS: CAD was assessed by coronary artery calcification (CAC) using computed-tomography in 561 patients with RA...
October 1, 2016: Arthritis & Rheumatology
Arash Mahdavi, Ali Mohammadzadeh, Golsa Joodi, Mohammad Reza Tabatabaei, Farhad Sheikholeslami, Marzieh Motevalli
BACKGROUND: There are numerous studies that address the diagnostic value of dual-source computed tomography (DSCT) as an alternative to conventional coronary angiography (CCA). However, the benefit of application of DSCT in a real world clinical setting should be evaluated. OBJECTIVES: To determine the diagnostic accuracy of DSCT technique compared with CCA as the gold standard method in detection of coronary artery stenosis among symptomatic patients who are presented to a referral cardiovascular center during daily clinical practice...
April 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
Reza Hanifehpour, Marzieh Motevalli, Hossein Ghanaati, Mona Shahriari, Mounes Aliyari Ghasabeh
BACKGROUND: Coronary artery calcium score (CACS) is a quantitative assessment of calcifications and an established predictor of cardiovascular events. OBJECTIVES: In this study, we evaluated the diagnostic accuracy, negative predictive value (NPV), positive predictive value (PPV), specificity and sensitivity of CACS less than 100 in predicting significant coronary artery stenosis in patients with risk of coronary artery disease (CAD) in a vessel-based analysis. PATIENTS AND METHODS: A cross sectional study was carried out on a study population of 2527 consecutive stable patients with symptoms suggestive of CAD who were referred for coronary computed tomographic angiography (CCTA)...
April 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
Maryam Zaid, Katsuyuki Miura, Akira Fujiyoshi, Robert D Abbott, Takashi Hisamatsu, Aya Kadota, Hisatomi Arima, Sayaka Kadowaki, Sayuki Torii, Naoko Miyagawa, Sentaro Suzuki, Naoyuki Takashima, Takayoshi Ohkubo, Akira Sekikawa, Hiroshi Maegawa, Minoru Horie, Yasuyuki Nakamura, Tomonori Okamura, Hirotsugu Ueshima
BACKGROUND: Low-density lipoprotein particle (LDL-P) has recently been found to be a stronger predictor of cardiovascular disease (CVD) than LDL-cholesterol (LDL-C). OBJECTIVES: Whether LDL-P is associated with subclinical atherosclerosis, independent of LDL-C, as well as other lipid measures has not been fully examined. We aimed to analyze LDL-P associations with measures of subclinical atherosclerosis. METHODS: We examined 870 Japanese men randomly selected from Kusatsu City, Shiga, Japan, aged 40-79 years from 2006-2008, free of clinical CVD and not using lipid-lowering medication...
September 2016: Journal of Clinical Lipidology
Qin Li, Songtao Liu, Kyle J Myers, Marios A Gavrielides, Rongping Zeng, Berkman Sahiner, Nicholas Petrick
RATIONALE AND OBJECTIVES: Different computed tomography imaging protocols and patient characteristics can impact the accuracy and precision of the calcium score and may lead to inconsistent patient treatment recommendations. The aim of this work was to determine the impact of reconstruction algorithm and gender characteristics on coronary artery calcium scoring based on a phantom study using computed tomography. MATERIALS AND METHODS: Four synthetic heart vessels with vessel diameters corresponding to female and male left main and left circumflex arteries containing calcification-mimicking materials (200-1000 HU) were inserted into a thorax phantom and were scanned with and without female breast plates (male and female phantoms, respectively)...
September 22, 2016: Academic Radiology
Yusuke Sakaguchi, Takayuki Hamano, Chikako Nakano, Yoshitsugu Obi, Isao Matsui, Yasuo Kusunoki, Daisuke Mori, Tatsufumi Oka, Nobuhiro Hashimoto, Yoshitsugu Takabatake, Atsushi Takahashi, Jun-Ya Kaimori, Toshiki Moriyama, Ryohei Yamamoto, Masaru Horio, Ken Sugimoto, Koichi Yamamoto, Hiromi Rakugi, Yoshitaka Isaka
BACKGROUND: The Agatston score, commonly used to quantify coronary artery calcification (CAC), is determined by the plaque area and density. Despite an excellent predictability of the Agatston score for cardiovascular events, the density of CAC has never been studied in patients with pre-dialysis chronic kidney disease (CKD). This study aimed to analyze the CAC density and its association with serum mineral levels in CKD. METHODS: We enrolled patients with pre-dialysis CKD who had diabetes mellitus, prior cardiovascular disease history, elevated low-density lipoprotein cholesterol levels, or smoking history...
2016: PloS One
Hussain Isma'eel, David Min, Laila Al-Shaar, Rory Hachamovitch, Sandra Halliburton, James Gentry, Brian Griffin, Paul Schoenhagen, Dermot Phelan
The 2013 American College of Cardiology/American Heart Association cardiovascular prevention guidelines use a new pooled cohort equation (PCE) to predict 10-year risk of atherosclerotic cardiovascular disease (ASCVD) events which form the basis of treatment recommendations. Coronary artery calcium score (CACS) has been proposed as a means to assess atherosclerotic risk. We sought to study the level of agreement in predicted ASCVD risk by CACS and PCE-calculated models and the potential impact on therapy of additional CACS testing...
August 23, 2016: American Journal of Cardiology
Philippe J van Rosendael, Vasileios Kamperidis, William K F Kong, Alexander R van Rosendael, Nina A Marsan, Jeroen J Bax, Victoria Delgado
The aim of this study was to compare the calcium burden of the aortic valve and coronary arteries with multidetector computed tomography (MDCT) in a propensity score-matched population of patients with a bicuspid versus a tricuspid aortic valve. From an ongoing clinical registry of patients who underwent MDCT, 70 patients with bicuspid aortic valve and 210 patients with tricuspid aortic valve were matched based on age, gender, cardiovascular risk factors, chest pain symptoms, and MDCT indication. Aortic valve calcium and the presence and severity of coronary artery disease were analyzed...
August 23, 2016: American Journal of Cardiology
Virginia M Miller, Vesna D Garovic, Kent R Bailey, Brian D Lahr, Michelle M Mielke, Wendy M White, Muthuvel Jayachandran
BACKGROUND AND AIMS: Having a history of preeclampsia increases the risk for future coronary artery calcification (CAC). This study evaluated the association of blood-borne, cell-derived microvesicles (MV) with CAC in middle-aged women. METHODS: Twelve pre-selected, antigen-specific MV were measured by digital flow cytometry in the blood of age- and parity-matched women (median age 60 years) without a history of cardiovascular events, but with either a history of preeclampsia (PE, n = 39) or normotensive pregnancy (NP, n = 40)...
October 2016: Atherosclerosis
Hussein Nafakhi, Abdulameer Al-Mosawi, Hayder Elwali, Hasan Al-Nafakh, Raad Tawfeq, Ahmed Nafakhi
OBJECTIVES: This study aimed to assess the effect of body mass index (BMI) on the relationship between pericardial fat volume (PFV), aortic root calcification (ARC) and coronary artery calcification (CAC) among patients with suspected coronary artery disease (CAD). METHODS: This cross-sectional study took place between January and December 2014 at the Kufa University Teaching Hospital, Najaf, Iraq. A total of 130 consecutive patients with an intermediate pretest probability of ischaemic heart disease who underwent 64-slice multidetector computed tomography (CT) angiography during the study period were recruited...
August 2016: Sultan Qaboos University Medical Journal
Keisuke Minami, Kihei Yoneyama, Masaki Izumo, Kengo Suzuki, Yasuyoshi Ogawa, Kousuke Chikaraishi, Yukihisa Ogawa, Yasuyuki Kobayashi, Toshiyuki Furukawa, Yasuhiro Tanabe, Yoshihiro J Akashi
BACKGROUND: Computed tomography is the best noninvasive imaging modality for evaluating valve leaflet calcification. OBJECTIVE: To evaluate the association of aortic valve leaflet calcification with instantaneous valve opening and closing using dynamic multidetector computed tomography (MDCT). METHODS: We retrospectively evaluated 58 consecutive patients who underwent dynamic MDCT imaging. Aortic valve calcification (AVC) was quantified using the Agatston method...
August 23, 2016: Journal of Cardiovascular Computed Tomography
Rodrigo Alonso, Pedro Mata, Ovidio Muñiz, Francisco Fuentes-Jimenez, Jose Luis Díaz, Daniel Zambón, Marta Tomás, Cesar Martin, Thomas Moyon, Mikaël Croyal, Aurélie Thedrez, Gilles Lambert
BACKGROUND AND AIMS: We aimed to assess whether elevated PCSK9 and lipoprotein (a) [Lp(a)] levels associate with coronary artery calcification (CAC), a good marker of atherosclerosis burden, in asymptomatic familial hypercholesterolemia. METHODS: We selected 161 molecularly defined FH patients treated with stable doses of statins for more than a year. CAC was measured using the Agatston method and quantified as categorical variable. Fasting plasma samples were collected and analyzed for lipids and lipoproteins...
August 27, 2016: Atherosclerosis
Jaewon Oh, Sungha Park, Hee Tae Yu, Hyuk Jae Chang, Sang Hak Lee, Seok Min Kang, Donghoon Choi
PURPOSE: Soluble ST2 (sST2) is an emerging prognostic biomarker in patients with cardiovascular disease (CVD). A recent study showed that sST2 predicted incident hypertension. High sensitive C-reactive protein (hsCRP) has been a widely-used biomarker for risk-stratifying in CVD. We compared the abilities of sST2 and hsCRP to predict high risk coronary artery calcium score (CACS). MATERIALS AND METHODS: The CACS was assessed by cardiac computed tomography, and sST2 was measured in 456 subjects enrolled in the Mapo-gu community cohort...
November 2016: Yonsei Medical Journal
Andrew D Choi, Eric S Leifer, Jeannie Yu, Sujata M Shanbhag, Kathie Bronson, Andrew E Arai, Marcus Y Chen
BACKGROUND: Coronary artery calcium (CAC) predicts coronary heart disease events and is important for individualized cardiac risk assessment. This report assesses the interscan variability of CT for coronary calcium quantification using image acquisition with standard and reduced radiation dose protocols and whether the use of reduced radiation dose acquisition with iterative reconstruction (IR; "reduced-dose/IR ") allows for similar image quality and reproducibility when compared to standard radiation dose acquisition with filtered back projection (FBP; "standard-dose/FBP") on 320-detector row computed tomography (320-CT)...
September 2016: Journal of Cardiovascular Computed Tomography
Marleen Vonder, Gert Jan Pelgrim, Sèvrin E M Huijsse, Mathias Meyer, Marcel J W Greuter, Thomas Henzler, Thomas G Flohr, Matthijs Oudkerk, Rozemarijn Vliegenthart
OBJECTIVES: To evaluate detectability and quantification of coronary calcifications for CT with a tin filter for spectral shaping. METHODS: Phantom inserts with 100 small and 9 large calcifications, and a moving artificial artery with 3 calcifications (speed 0-30 mm/s) were placed in a thorax phantom simulating different patient sizes. The phantom was scanned in high-pitch spiral mode at 100 kVp with tin filter (Sn100 kVp), and at a reference of 120 kVp, with electrocardiographic (ECG) gating...
August 29, 2016: European Radiology
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