Alberto Lazari, Mohamed Tachrount, Juan Miguel Valverde, Daniel Papp, Antoine Beauchamp, Paul McCarthy, Jacob Ellegood, Joanes Grandjean, Heidi Johansen-Berg, Valerio Zerbi, Jason P Lerch, Rogier B Mars
While humans are known to have several premotor cortical areas, secondary motor cortex (M2) is often considered to be the only higher-order motor area of the mouse brain and is thought to combine properties of various human premotor cortices. Here, we show that axonal tracer, functional connectivity, myelin mapping, gene expression, and optogenetics data contradict this notion. Our analyses reveal three premotor areas in the mouse, anterior-lateral motor cortex (ALM), anterior-lateral M2 (aM2), and posterior-medial M2 (pM2), with distinct structural, functional, and behavioral properties...
May 7, 2024: Cell Reports