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https://www.readbyqxmd.com/read/28240006/effects-of-six-weeks-endurance-training-and-aloe-vera-supplementation-on-cox-2-and-vegf-levels-in-mice-with-breast-cancer
#1
Saeed Shirali, Alireza Barari, Seyed Ahmad Hosseini, Elaheh Khodadi
The aim of this study was to determine effects of six weeks endurance training and Aloe Vera supplementation on COX-2 and VEGF levels in mice with breast cancer. For this purpose, 35 rats were randomly divided into 5 groups: control (healthy) and 4 cancer groups: control (cancer only), training, Aloe Vera and Aloe Vera + training. Breast cancer tumors were generated in mice by implantind. The training program comprised six weeks of swimming training accomplished in three sessions per week. Training time started with 10 minutes on the first day and increased to 60 minutes in the second week and the water flow rate was increased from 7 to 15 liters per minute at a constant rate...
1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28239997/effects-of-different-doses-of-silk-peptide-on-energy-metabolism-during-exercise-in-mice
#2
Suh Heajung, Kim Jisu, Park Jonghoon, Kim Bokyung, Lee Chi-Ho, Lim Kiwon
Purpose: This study was carried out to determine the optimal dose of silk peptide for enhancing fat metabolism during exercise. Methods: Fifty male ICR mice were randomly divided into five groups: Sed, SP0, SP200, SP400, and SP800. All SP mice underwent training by running on a treadmill 5 times a week for 2 weeks (20 m/min, 8° slope, 50 min/day for the first week and 25 m/min, 8° slope, 50 min/day at about 70-75% of maximum oxygen uptake for the second week)...
February 24, 2017: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/28239983/targeted-deletion-of-gd3-synthase-protects-against-mptp-induced-neurodegeneration
#3
Yada Akkhawattanangkul, Panchanan Maiti, Yi Xue, Dipendra Aryal, William C Wetsel, David Hamilton, Stephen C Fowler, Michael P McDonald
Parkinson's disease is a debilitating neurodegenerative condition for which there is no cure. Converging evidence implicates gangliosides in the pathogenesis of several neurodegenerative diseases, suggesting a potential new class of therapeutic targets. We have shown that interventions that simultaneously increase the neuroprotective GM1 ganglioside and decrease the pro-apoptotic GD3 ganglioside-such as inhibition of GD3 synthase (GD3S) or administration of sialidase-are neuroprotective in vitro and in a number of preclinical models...
February 27, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28239908/pathogenicity-of-conidiobolus-coronatus-and-fusarium-solani-in-mouse-models
#4
Yadi Li, Xiangang Fang, Xiaoqian Zhou, Suying Geng, Yuxin Wang, Xiumin Yang
To study the pathogenicity of Conidiobolus coronatus (C. coronatus) and Fusarium solani (F. solani) in animal models. Immunocompromised mice were treated with cyclophosphamide and prednisolone via intraperitoneal injection before and after inoculation. According to pathogenic characteristics of different fungi, C. coronatus was used to infect mice via intravenous inoculation, intraperitoneal inoculation, gastrointestinal infusion and intradermal inoculation methods. And F. solani was used to infect mice by inoculation via the abraded or normal skin...
February 27, 2017: Mycoses
https://www.readbyqxmd.com/read/28239846/inhibition-of-6-phosphofructo-2-kinase-suppresses-fibroblast-like-synoviocytes-mediated-synovial-inflammation-and-joint-destruction-in-rheumatoid-arthritis
#5
Yaoyao Zou, Shan Zeng, Mingcheng Huang, Qian Qiu, Youjun Xiao, Maohua Shi, Zhongping Zhan, Liuqin Liang, Xiuyan Yang, Hanshi Xu
BACKGROUND AND PURPOSE: Abnormal glycolytic metabolism contributes to joint inflammation in rheumatoid arthritis (RA). The aims of this study were to investigate the role of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), a bifunctional enzyme that controls the glycolytic rate, in regulating fibroblast-like synoviocyte (FLS)-mediated synovial inflammation and invasiveness in RA. EXPERIMENTAL APPROACH: A specific PFKFB3 inhibitor, PFK15, and siRNA were used to evaluate the role of PFKFB3...
February 27, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28239822/the-relationship-between-the-expression-of-tam-survivin-and-the-degree-of-necrosis-of-the-tumor-after-cisplatin-treatment-in-osteosarcoma
#6
G Chen
OBJECTIVE: To explore the relationship between the expression of TAM, survivin and the degree of necrosis of the tumor after cisplatin treatment in osteosarcoma. MATERIALS AND METHODS: The mice model of osteosarcoma S180 were injected with 6 mg/kg/day of cisplatin (observation group) or the same amount of normal saline (control group) for 4 weeks. Mice were sacrificed at days 1, 4, 9, 14, 18, 22 and 28, respectively, 24 h before administration of the drug or saline, and tumor tissues were collected...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28239790/antibodies-to-glutamate-reversed-the-amnesic-effects-of-proinflammatory-s100a9-protein-fibrils-in-aged-c57bl-6-mice
#7
M A Gruden, T V Davydova, V G Fomina, L A Vetrile, L A Morozova-Roche, R D E Sewell
Chronic intranasal administration of fibrillar structures of proinflammatory S100A9 protein impaired passive avoidance learning in old C57Bl/6 mice. Combined treatment with S100A9 fibrils and antibodies to glutamate was followed by an increase in horizontal locomotor activity of animals in the open-field test and did not disturb spatial memory.
February 27, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28239785/pharmacological-analysis-of-the-therapeutic-effect-of-radioprotectors-cystamine-and-indralin-in-the-capacity-of-radiomitigators
#8
M V Vasin, I B Ushakov, V Yu Kovtun, S N Komarova, L A Semenova, A A Galkin, R V Afanas'ev, I V Bukhtiyarov
The therapeutic radiomitigating effect of cystamine and indralin was studied in experiments on mice and rats and pharmacological analysis of these drugs was carried out. The animals were subjected to whole-body (60)Co γ-irradiation. The mice were exposed to single (9-10 Gy) or double (8 Gy) irradiation with an interval of 1 month. The rats were exposed to 10 Gy with partial shielding of the upper quarter of the abdomen. In experiments on mice, pretreatment with reserpine abolished the therapeutic effect of cystamine administered repeatedly every 15 min over 1 h after irradiation...
February 27, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28239767/down-regulation-of-pin1-in-temporal-lobe-epilepsy-patients-and-mouse-model
#9
Lan Tang, Yanke Zhang, Guojun Chen, Yan Xiong, Xuefeng Wang, Binglin Zhu
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) is a unique PPIase belonging to the parvulin family, and it isomerizes peptide bond between phospho-(Ser/Thr) and Pro. Pin1 has been linked to the pathogenesis of various human diseases; however, its exact biological functions remain unclear. The aim of the present study is to explore the expression pattern of Pin1 in patients with refractory epilepsy and in a chronic pilocarpine-induced epileptic mouse model. Using Western blot, immunofluorescence and immunoprecipitation analysis, we found that Pin1 protein was mainly distributed in neurons, demonstrated by colocalization with the dendritic marker, MAP2...
February 27, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28239698/beneficial-effects-of-apple-peel-polyphenols-on-vascular-endothelial-dysfunction-and-liver-injury-in-high-choline-fed-mice
#10
Mengfan Jia, Daoyuan Ren, Yan Nie, Xingbin Yang
This study was designed to investigate the preventive effects of Red Fuji apple peel polyphenolic extract (APP) on vascular endothelial dysfunction and liver injury in mice fed a high choline diet. The mice were fed 3% dietary choline in drinking water for 8 weeks and displayed vascular dysfunction and liver damage (p < 0.01). The administration of APP at 600 and 900 mg per kg bw significantly elevated serum NO, HDL and 6-Keto-PGF1a levels and lowered serum TC, TG, LDL, ET-1 and TXB2 levels in the HC-fed mice...
February 27, 2017: Food & Function
https://www.readbyqxmd.com/read/28239679/adenovirus-serotype-5-vaccine-vectors-trigger-il-27-dependent-inhibitory-cd4-t-cell-responses-that-impair-cd8-t-cell-function
#11
Rafael A Larocca, Nicholas M Provine, Malika Aid, M Justin Iampietro, Erica N Borducchi, Alexander Badamchi-Zadeh, Peter Abbink, David Ng'ang'a, Christine A Bricault, Eryn Blass, Pablo Penaloza-MacMaster, Kathryn E Stephenson, Dan H Barouch
Adenovirus serotype 5 (Ad5) vaccine vectors elicit robust CD8(+) T cell responses, but these responses typically exhibit a partially exhausted phenotype. However, the immunologic mechanism by which Ad5 vectors induce dysfunctional CD8(+) T cells has not previously been elucidated. Here we demonstrate that, following immunization of B6 mice, Ad5 vectors elicit antigen-specific IL-10(+)CD4(+) T cells with a distinct transcriptional profile in a dose-dependent fashion. In rhesus monkeys, we similarly observed upregulated expression of IL-10 and PD-1 by CD4(+) T cells following Ad5 vaccination...
November 2016: Science Immunology
https://www.readbyqxmd.com/read/28239673/effectiveness-of-a-walnut-enriched-diet-on-murine-sperm-involvement-of-reduced-peroxidative-damage
#12
Lauren S Coffua, Patricia A Martin-DeLeon
A walnut supplement for a Western-style diet in men was shown to improve sperm motility, vitality, and morphology. To gain further insights into factors underlying this improvement, we administered a parallel walnut-enriched diet to mice [including those with a defect in sperm motility due to deletion of Plasma Membrane Ca(2+)-ATPase 4 (Pmca4(-/-) )] to determine if there is a similar improvement that is accompanied by reduced sperm membrane peroxidative damage. Although sperm vitality and acrosome reaction rate were unaffected, the diet led to a significant improvement in motility (P < 0...
February 2017: Heliyon
https://www.readbyqxmd.com/read/28239665/myeloid-12-15-lox-regulates-b-cell-numbers-and-innate-immune-antibody-levels-in-vivo
#13
Sarah N Lauder, Victoria J Tyrrell, Keith Allen-Redpath, Maceler Aldrovandi, David Gray, Peter Collins, Simon A Jones, Philip R Taylor, Valerie O'Donnell
Background. The myeloid enzyme 12/15-lipoxygenase (LOX), which generates bioactive oxidized lipids, has been implicated in numerous inflammatory diseases, with several studies demonstrating an improvement in pathology in mice lacking the enzyme. However, the ability of 12/15-LOX to directly regulate B cell function has not been studied. Methods. The influence of 12/15-LOX on B cell phenotype and function, and IgM generation, was compared using wildtype (WT) and 12/15-LOX (Alox15(-/-)) deficient mice. The proliferative and functional capacity of splenic CD19(+) B cells was measured in vitro in response to various toll-like receptor agonists...
January 4, 2017: Wellcome Open Res
https://www.readbyqxmd.com/read/28239662/zika-virus-infects-cells-lining-the-blood-retinal-barrier-and-causes-chorioretinal-atrophy-in-mouse-eyes
#14
Pawan Kumar Singh, John-Michael Guest, Mamta Kanwar, Joseph Boss, Nan Gao, Mark S Juzych, Gary W Abrams, Fu-Shin Yu, Ashok Kumar
Zika virus (ZIKV) is an important pathogen that causes not only neurologic, but also ocular, abnormalities. Thus, it is imperative that models to study ZIKV pathogenesis in the eye are developed to identify potential targets for interventions. Here, we studied ZIKV interactions with human retinal cells and evaluated ZIKV's pathobiology in mouse eyes. We showed that cells lining the blood-retinal barrier (BRB), the retinal endothelium, and retinal pigment epithelium (RPE) were highly permissive and susceptible to ZIKV-induced cell death...
February 23, 2017: JCI Insight
https://www.readbyqxmd.com/read/28239656/autoreactive-helper-t-cells-alleviate-the-need-for-intrinsic-tlr-signaling-in-autoreactive-b-cell-activation
#15
Josephine R Giles, Adriana Turqueti Neves, Ann Marshak-Rothstein, Mark J Shlomchik
T cells play a significant role in the pathogenesis of systemic autoimmune diseases, including systemic lupus erythematosus; however, there is relatively little information on the nature and specificity of autoreactive T cells. Identifying such cells has been technically difficult because they are likely to be rare and low affinity. Here, we report a method for identifying autoreactive T cell clones that recognize proteins contained in autoantibody immune complexes, providing direct evidence that functional autoreactive helper T cells exist in the periphery of normal mice...
February 23, 2017: JCI Insight
https://www.readbyqxmd.com/read/28239655/alterations-in-sarcomere-function-modify-the-hyperplastic-to-hypertrophic-transition-phase-of-mammalian-cardiomyocyte-development
#16
Benjamin R Nixon, Alexandra F Williams, Michael S Glennon, Alejandro E de Feria, Sara C Sebag, H Scott Baldwin, Jason R Becker
It remains unclear how perturbations in cardiomyocyte sarcomere function alter postnatal heart development. We utilized murine models that allowed manipulation of cardiac myosin-binding protein C (MYBPC3) expression at critical stages of cardiac ontogeny to study the response of the postnatal heart to disrupted sarcomere function. We discovered that the hyperplastic to hypertrophic transition phase of mammalian heart development was altered in mice lacking MYBPC3 and this was the critical period for subsequent development of cardiomyopathy...
February 23, 2017: JCI Insight
https://www.readbyqxmd.com/read/28239649/switching-harmful-visceral-fat-to-beneficial-energy-combustion-improves-metabolic-dysfunctions
#17
Xiaoyan Yang, Wenhai Sui, Meng Zhang, Mei Dong, Sharon Lim, Takahiro Seki, Ziheng Guo, Carina Fischer, Huixia Lu, Cheng Zhang, Jianmin Yang, Meng Zhang, Yangang Wang, Caixia Cao, Yanyan Gao, Xingguo Zhao, Meili Sun, Yuping Sun, Rujie Zhuang, Nilesh J Samani, Yun Zhang, Yihai Cao
Visceral fat is considered the genuine and harmful white adipose tissue (WAT) that is associated to development of metabolic disorders, cardiovascular disease, and cancer. Here, we present a new concept to turn the harmful visceral fat into a beneficial energy consumption depot, which is beneficial for improvement of metabolic dysfunctions in obese mice. We show that low temperature-dependent browning of visceral fat caused decreased adipose weight, total body weight, and body mass index, despite increased food intake...
February 23, 2017: JCI Insight
https://www.readbyqxmd.com/read/28239648/liver-x-receptor-%C3%AE-mediates-hepatic-triglyceride-accumulation-through-upregulation-of-g0-g1-switch-gene-2-expression
#18
Bradlee L Heckmann, Xiaodong Zhang, Alicia M Saarinen, Gabriele Schoiswohl, Erin E Kershaw, Rudolf Zechner, Jun Liu
Liver X receptors (LXRs) are transcription factors essential for cholesterol homeostasis and lipogenesis. LXRα has been implicated in regulating hepatic triglyceride (TG) accumulation upon both influx of adipose-derived fatty acids (FAs) during fasting and stimulation of de novo FA synthesis by chemical agonism of LXR. However, whether or not a convergent mechanism is employed to drive deposition of FAs from these 2 different sources in TGs is undetermined. Here, we report that the G0/G1 Switch Gene 2 (G0S2), a selective inhibitor of intracellular TG hydrolysis/lipolysis, is a direct target gene of LXRα...
February 23, 2017: JCI Insight
https://www.readbyqxmd.com/read/28239621/assay-to-evaluate-bal-fluid-regulation-of-fibroblast-%C3%AE-sma-expression
#19
Jennifer L Larson-Casey, A Brent Carter
: Because transforming growth factor-β (TGF-β1) induces differentiation of fibroblasts to myofibroblasts, we developed a protocol to evaluate alveolar macrophage-derived TGF-β1 regulation of lung fibroblast differentiation (Larson-Casey et al., 2016). The protocol allows evaluating the ability of mouse bronchoalveolar lavage (BAL) fluid to alter fibroblast differentiation. Fibroblast differentiation was measured by the expression of α-smooth muscle actin (α-SMA). BACKGROUND: Alveolar macrophages play an integral role in pulmonary fibrosis development by increasing the expression of TGF-β1 (He et al...
November 20, 2016: Bio-protocol
https://www.readbyqxmd.com/read/28239559/gene-profiling-the-window-of-implantation-microarray-analyses-from-human-and-rodent-models
#20
Jennifer L Herington, Yan Guo, Jeff Reese, Bibhash C Paria
Poor uterine receptivity leads to implantation defects or failure. Identification of uterine molecules crucial to uterine receptivity and/or embryo implantation provides the opportunity to design a diagnostic screening toolkit for uterine receptivity or targeted drug discovery for treating implantation-based infertility. In this regard, gene-profiling studies performed in humans and rodents have identified numerous genes involved in the transcriptional regulation of uterine receptivity and embryo implantation...
December 2016: J Reprod Health Med
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