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EM simulation

Daniel R Ripoll, Ilja Khavrutskii, Anders Wallqvist, Sidhartha Chaudhury
Cryo-electron-microscopy (cryo-EM) structures of flaviviruses reveal significant variation in epitope occupancy across different monoclonal antibodies that have largely been attributed to epitope-level differences in conformation or accessibility that affect antibody binding. The consequences of these variations for macroscopic properties such as antibody binding and neutralization are the results of the law of mass action-a stochastic process of innumerable binding and unbinding events between antibodies and the multiple binding sites on the flavivirus in equilibrium-that cannot be directly imputed from structure alone...
October 18, 2016: Biophysical Journal
Priten Savaliya, Anuj Dhawan
Employing finite difference time domain simulations, we demonstrate that electromagnetic field enhancement is substantially greater for tapered optical fibers with plasmonic nanostructures present on their tips as compared with non-tapered optical fibers having those plasmonic nanostructures, or with tapered optical fibers without the plasmonic nanostructures. We also carried out fabrication of plasmonic nanostructures on optical fiber tips.
October 1, 2016: Optics Letters
Andrew Petrosoniak, Marc Auerbach, Ambrose H Wong, Christopher M Hicks
In situ simulation (ISS), a point of care training strategy that occurs within the patient care environment involving actual healthcare team members, provides additional benefits to centre-based simulation. ISS can serve several roles within emergency medicine (EM): improves provider/team performance, identifies and mitigates threats to patient safety and improves systems and infrastructure. The effective use of ISS fosters inter-professional team training and a culture of safety essential for high performance EM teams and resilient systems...
October 17, 2016: Emergency Medicine Australasia: EMA
Isabelle Bragard, Marie-Christine Seghaye, Nesrine Farhat, Marie Solowianiuk, Mariane Saliba, Anne-Marie Etienne, Katharina Schumacher
OBJECTIVES: Residents beginning their specialization in pediatrics and emergency medicine (EM) are rapidly involved in oncall duties. Early acquisition of crisis resource management by novice residents is essential for patient safety, but traditional training may be insufficient. Our aim was to investigate the impact of a 2-day simulation-based course on residents to manage pediatric and neonatal patients. METHODS: First year residents participated in the course...
October 6, 2016: Pediatric Emergency Care
Luciana Mara Monti Fonseca, Natália Del' Angelo Aredes, Ananda Maria Fernandes, Luís Manuel da Cunha Batalha, Jorge Manuel Amado Apóstolo, José Carlos Amado Martins, Manuel Alves Rodrigues
Objectives: to evaluate the cognitive learning of nursing students in neonatal clinical evaluation from a blended course with the use of computer and laboratory simulation; to compare the cognitive learning of students in a control and experimental group testing the laboratory simulation; and to assess the extracurricular blended course offered on the clinical assessment of preterm infants, according to the students. Method: a quasi-experimental study with 14 Portuguese students, containing pretest, midterm test and post-test...
October 10, 2016: Revista Latino-americana de Enfermagem
Kyoung-Nam Kim, Sang-Doc Han, Jeung-Hoon Seo, Phil Heo, Dongkyeom Yoo, Geun Ho Im, Jung Hee Lee
The birdcage (BC) coil is currently being utilized for uniform radiofrequency (RF) transmit/receive (Tx/Rx) or Tx-only configuration in many magnetic resonance (MR) imaging applications, but insufficient magnetic flux (|B1|) density and their non-uniform distribution still exists in high-field (HF) environments. We demonstrate that the asymmetric birdcage (ABC) transmit/receive (Tx/Rx) volume coil, which is a modified standard birdcage (SBC) coil with the end ring split into two halves, is suitable for improving the |B1| sensitivity in 7T small-animal MR imaging...
September 30, 2016: Magnetic Resonance in Medical Sciences: MRMS
Yuedong Xie, Zenghua Liu, Liyuan Yin, Jiande Wu, Peng Deng, Wuliang Yin
This paper presents the simulation and experimental study of the radiation pattern of a meander-line-coil EMAT. A wholly analytical method, which involves the coupling of two models: an analytical EM model and an analytical UT model, has been developed to build EMAT models and analyse the Rayleigh waves' beam directivity. For a specific sensor configuration, Lorentz forces are calculated using the EM analytical method, which is adapted from the classic Deeds and Dodd solution. The calculated Lorentz force density are imported to an analytical ultrasonic model as driven point sources, which produce the Rayleigh waves within a layered medium...
September 17, 2016: Ultrasonics
Nicolas Coudray, Sean L Seyler, Ralph Lasala, Zhening Zhang, Kathy M Clark, Mark E Dumont, Alexis Rohou, Oliver Beckstein, David L Stokes
Bor1p is a secondary transporter in yeast that is responsible for boron transport. Bor1p belongs to the SLC4 family which controls bicarbonate exchange and pH regulation in animals as well as borate uptake in plants. The SLC4 family is more distantly related to members of the Amino acid-Polyamine-organoCation (APC) superfamily, which includes well studied transporters such as LeuT, Mhp1, AdiC, vSGLT, UraA, SLC26Dg. Their mechanism generally involves relative movements of two domains: a core domain that binds substrate and a gate domain that in many cases mediates dimerization...
October 7, 2016: Protein Science: a Publication of the Protein Society
Shuntaro Arase, Kanta Horie, Takashi Kato, Akira Noda, Yasuhiro Mito, Masatoshi Takahashi, Toshinobu Yanagisawa
Multivariate curve resolution-alternating least squares (MCR-ALS) method was investigated for its potential to accelerate pharmaceutical research and development. The fast and efficient separation of complex mixtures consisting of multiple components, including impurities as well as major drug substances, remains a challenging application for liquid chromatography in the field of pharmaceutical analysis. In this paper we suggest an integrated analysis algorithm functioning on a matrix of data generated from HPLC coupled with photo-diode array detector (HPLC-PDA) and consisting of the mathematical program for the developed multivariate curve resolution method using an expectation maximization (EM) algorithm with a bidirectional exponentially modified Gaussian (BEMG) model function as a constraint for chromatograms and numerous PDA spectra aligned with time axis...
October 21, 2016: Journal of Chromatography. A
Jin Seob Kim, Bijan Afsari, Gregory S Chirikjian
Cryo-electron microscopy (EM) and small angle X-ray scattering (SAXS) are two different data acquisition modalities often used to glean information about the structure of large biomolecular complexes in their native states. A SAXS experiment is generally considered fast and easy but unveils the structure at very low resolution, whereas a cryo-EM experiment needs more extensive preparation and postacquisition computation to yield a three-dimensional (3D) density map at higher resolution. In certain applications, we may need to verify whether the data acquired in the SAXS and cryo-EM experiments correspond to the same structure (e...
October 6, 2016: Journal of Computational Biology: a Journal of Computational Molecular Cell Biology
Jimin Wang, Peter B Moore
The images of flash-frozen biological macromolecules produced by cryo-electron microscopy (EM) can be used to generate accurate, three-dimensional, electric potential maps for these molecules that resemble X-ray-derived electron density maps. However, unlike electron density maps, electric potential maps can include negative features that might for example represent the negatively charged, backbone phosphate groups of nucleic acids or protein carboxylate side chains, which can complicate their interpretation...
October 5, 2016: Protein Science: a Publication of the Protein Society
Shuling Liu, Amita K Manatunga, Limin Peng, Michele Marcus
In many biomedical studies that involve correlated data, an outcome is often repeatedly measured for each individual subject along with the number of these measurements, which is also treated as an observed outcome. This type of data has been referred as multivariate random length data by Barnhart and Sampson (1995). A common approach to handling such type of data is to jointly model the multiple measurements and the random length. In previous literature, a key assumption is the multivariate normality for the multiple measurements...
October 4, 2016: Biometrics
Yeqian Liu, Tao Hu, Jianguo Sun
This paper discusses regression analysis of current status data, a type of failure time data where each study subject is observed only once, in the presence of dependent censoring. Furthermore, there may exist a cured subgroup, meaning that a proportion of study subjects are not susceptible to the failure event of interest. For the problem, we develop a sieve maximum likelihood estimation approach with the use of latent variables and Bernstein polynomials. For the determination of the proposed estimators, an EM algorithm is developed and the asymptotic properties of the estimators are established...
September 30, 2016: Lifetime Data Analysis
Dongbing Lai, Huiping Xu, Daniel Koller, Tatiana Foroud, Sujuan Gao
Dementia patients exhibit considerable heterogeneity in individual trajectories of cognitive decline, with some patients showing rapid decline following diagnoses while others exhibiting slower decline or remaining stable for several years. Dementia studies often collect longitudinal measures of multiple neuropsychological tests aimed to measure patients' decline across a number of cognitive domains. We propose a multivariate finite mixture latent trajectory model to identify distinct longitudinal patterns of cognitive decline simultaneously in multiple cognitive domains, each of which is measured by multiple neuropsychological tests...
2016: Journal of Applied Statistics
Liang Peng, Peiwei Chen, Aiting Wu, Gaofeng Wang
In this paper, coupled split-ring resonators (SRRs) are used to construct the electrically small antennas. We show that through strong magnetic coupling, the coupled SRRs composite can oscillate at a wavelength much larger than its total size. Due to its magnetic dipole feature, the coupled SRRs composite allows the electromagnetic (EM) power to radiate and hence forms the electrically small antenna (ESA). Because of the high-Q resonance, the ESA could be easily matched to the driving circuit in the microwave region, through mutual induction approach...
2016: Scientific Reports
Felipe Perez, Gilbert Millholland, Seshasai Vamsi Krishna Peddinti, Ashok Kumar Thella, James Rizkalla, Paul Salama, Maher Rizkalla, Jorge Morisaki, Maher E Rizkalla
The impact of the electromagnetic waves (EM) on human neurons (HN) has been under investigation for decades, in efforts to understand the impact of cell phones (radiation) on human health, or radiation absorption by HN for medical diagnosis and treatment. Research issues including the wave frequency, power intensity, reflections and scattering, and penetration depths are of important considerations to be incorporated into the research study. In this study, computer simulation for the EM exposure to HN was studied for the purpose of determining the upper limits of the electric and magnetic field intensities, power consumption, reflections and transmissions, and the change in temperature resulting from the power absorption by human neurons...
August 2016: Journal of Biomedical Science and Engineering
Linna Guan, Amanda Suggs, Sayeeda Ahsanuddin, Madeline Tarrillion, Jacqueline Selph, Minh Lam, Elma Baron
Exposure of the skin to ultraviolet (UV) irradiation causes many detrimental effects through mechanisms related to oxidative stress and DNA damage. Excessive oxidative stress can cause apoptosis and cellular dysfunction of epidermal cells leading to cellular senescence and connective tissue degradation. Direct and indirect damage to DNA predisposes the skin to cancer formation. Chronic UV exposure also leads to skin aging manifested as wrinkling, loss of skin tone, and decreased resilience. Fortunately, human skin has several natural mechanisms for combating UV-induced damage...
September 1, 2016: Journal of Drugs in Dermatology: JDD
Sinan Fang, Heping Pan, Ting Du, Ahmed Amara Konaté, Chengxiang Deng, Zhen Qin, Bo Guo, Ling Peng, Huolin Ma, Gang Li, Feng Zhou
This study applied the finite-difference time-domain (FDTD) method to forward modeling of the low-frequency crosswell electromagnetic (EM) method. Specifically, we implemented impulse sources and convolutional perfectly matched layer (CPML). In the process to strengthen CPML, we observed that some dispersion was induced by the real stretch κ, together with an angular variation of the phase velocity of the transverse electric plane wave; the conclusion was that this dispersion was positively related to the real stretch and was little affected by grid interval...
2016: Scientific Reports
Wei Vivian Zhuang, Joanne M Murabito, Kathryn L Lunetta
BACKGROUND: In longitudinal epidemiological studies there may be individuals with rich phenotype data who die or are lost to follow-up before providing DNA for genetic studies. Often, the genotypic and phenotypic data of the relatives are available. Two strategies for analyzing the incomplete data are to exclude ungenotyped subjects from analysis (the complete-case method, CC) and to include phenotyped but ungenotyped individuals in analysis by using relatives' genotypes for genotype imputation (GI)...
August 31, 2016: Human Heredity
Danny Riethorst, Peter Baatsen, Caroline Remijn, Amitava Mitra, Jan Tack, Joachim Brouwers, Patrick Augustijns
Intestinal fluids dictate the intraluminal environment, and therefore, they substantially affect the absorption of orally taken drugs. The characterization of human intestinal fluids (HIF) and the design of simulated intestinal fluids (SIF) mainly focus on composition, not necessarily taking into account the ultrastructure of HIF. Colloidal structures in HIF and SIF can enhance the solubilizing capacity for lipophilic drugs while decreasing the bioaccessible fraction. As such, colloids present in HIF play a crucial role and require an in-depth characterization...
October 3, 2016: Molecular Pharmaceutics
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