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https://www.readbyqxmd.com/read/28590015/mucinous-adenocarcinoma-of-prostate-and-prostatic-adenocarcinoma-with-mucinous-components-a-clinicopathological-analysis-of-143-cases
#1
Hemamali Samaratunga, Brett Delahunt, John R Srigley, John Yaxley, Shulammite Johannsen, Geoffrey Coughlin, Troy Gianduzzo, Boon Kua, Imogen Patterson, John N Nacey, Lars Egevad
The clinical significance of mucinous prostatic adenocarcinoma remains uncertain. From 6440 cases of prostatic adenocarcinoma treated by radical prostatectomy and reported by Aquesta Uropathology from 2009 to 2014, mucinous components of 5-100% were found in 143 (2.2%). The mean age was 61.4 years, mean preoperative serum was PSA 7.8 ng/mL and clinical stage category was cT1 in 81% and cT2 in 19% of cases. Cases were graded using the 2014 International Society of Urological Pathology recommendation of grading the underlying architecture and Gleason scores were 3+4 in 13...
June 7, 2017: Histopathology
https://www.readbyqxmd.com/read/28380477/utility-of-the-paris-system-in-reporting-urine-cytology
#2
COMPARATIVE STUDY
Kiran Malviya, Gwendolyn Fernandes, Leena Naik, Kanchan Kothari, Mona Agnihotri
OBJECTIVE: To find out the utility of The Paris System (TPS) in reporting urine cytology and to compare it with the reporting system currently used in our laboratory. STUDY DESIGN: This retrospective study was undertaken over a period of 1 year during which slides of all the urine specimens sent for cytological examination were retrieved from our laboratory filling system. They were blindly reviewed and reclassified according to TPS. Surgical follow-up was obtained from the uropathology services of our department...
2017: Acta Cytologica
https://www.readbyqxmd.com/read/28111042/-immunotherapy-in-uropathology
#3
Virginie Verkarre, Hélène Roussel, Clémence Granier, Eric Tartour, Yves Allory
The algorithms for treatment of metastatic cancers are evolving due to positive results obtained with immunotherapy. Therapeutics approaches to stimulate the immune system have already been used in the treatment of kidney and bladder cancer, such as the administration of cytokines and BCG therapy, confirming the immunogenicity of these tumors. The aim of immunotherapies is not only to activate the immune system against tumor cells, but also to take into account the tumor-induced suppressive microenvironment, in particular by removing the anergy of T-cell lymphocytes, and by targeting the co-stimulation inhibitors molecules...
February 2017: Annales de Pathologie
https://www.readbyqxmd.com/read/27638524/-session-report-of-the-uropathology-working-group-of-the-german-society-of-pathology-2016
#4
P J Wild, G Kristiansen
No abstract text is available yet for this article.
November 2016: Der Pathologe
https://www.readbyqxmd.com/read/27473787/-pathological-advances-in-renal-prostatic-bladder-and-testis-neoplasia
#5
REVIEW
N Rioux-Leclercq, E Comperat, S-F Kammerer-Jacquet, P Camparo, G Fromont
INTRODUCTION: The ISUP (International Society of Urological Pathology) Consensus Conferences between 2012 and 2015 made recommendations regarding the classification, staging, prognostic factors of adult tumors from kidney, prostate, bladder and testis. The main points of these recommendations are highlighted in this article. MATERIALS AND METHODS: This article is based on a systematic literature search by using different keywords "cancer, kidney, prostate, bladder, testis, pathology, classification" from Pubmed database...
June 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27458566/skin-disorders-in-peritoneal-dialysis-patients-an-underdiagnosed-subject
#6
Meltem Gursu, Sami Uzun, Derya Topcuoğlu, Leyli Kadriye Koc, Lamiye Yucel, Abdullah Sumnu, Egemen Cebeci, Oktay Ozkan, Ahmet Behlul, Leyla Koc, Savas Ozturk, Rumeyza Kazancioglu
AIM: To examine all skin changes in peritoneal dialysis (PD) patients followed up in our unit. METHODS: Patients on PD program for at least three months without any known chronic skin disease were included in the study. Patients with already diagnosed skin disease, those who have systemic diseases that may cause skin lesions, patients with malignancies and those who did not give informed consent were excluded from the study. All patients were examined by the same predetermined dermatologist with all findings recorded...
July 6, 2016: World Journal of Nephrology
https://www.readbyqxmd.com/read/27346573/improvement-of-diagnostic-agreement-among-pathologists-in-resolving-an-atypical-glands-suspicious-for-cancer-diagnosis-in-prostate-biopsies-using-a-novel-disease-focused-diagnostic-review-quality-improvement-process
#7
Rajal B Shah, Gioacchino Leandro, Gloria Romerocaces, James Bentley, Jiyoon Yoon, Savvas Mendrinos, Yousef Tadros, Wei Tian, Richard Lash
One of the major goals of an anatomic pathology laboratory quality program is to minimize unwarranted diagnostic variability and equivocal reporting. This study evaluated the utility of Miraca Life Sciences' "Disease-Focused Diagnostic Review" (DFDR) quality program in improving interobserver diagnostic reproducibility associated with classification of "atypical glands suspicious for adenocarcinoma" (ATYP) in prostate biopsies. Seventy-one selected prostate biopsies with a focus of ATYP were reviewed by 8 pathologists...
October 2016: Human Pathology
https://www.readbyqxmd.com/read/27180057/malakoplakia-associated-with-prostatic-adenocarcinoma-report-of-4-cases-and-literature-review
#8
REVIEW
Shaun Medlicott, Cristina Magi-Galluzzi, Rafael E Jimenez, Kiril Trpkov
Malakoplakia is an inflammatory process that has been rarely reported in the prostate. Malakoplakia in association with prostatic carcinoma is exceedingly rare with only 4 previously reported cases. We describe the clinical features and the associated pathology in 4 patients who demonstrated malakoplakia of the prostate in association with prostatic adenocarcinoma. Prostatic malakoplakia presenting in association with prostatic adenocarcinoma was identified in 4 patients through a search from the records of 3 institutional databases with large in-house and consult uropathology practices...
June 2016: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/26821327/-uropathology
#9
A Hartmann, R Knüchel-Clarke, G Kristiansen
No abstract text is available yet for this article.
February 2016: Der Pathologe
https://www.readbyqxmd.com/read/26791567/usefulness-of-pt1-substaging-in-papillary-urothelial-bladder-carcinoma
#10
MULTICENTER STUDY
Carlo Patriarca, Rodolfo Hurle, Marco Moschini, Massimo Freschi, Piergiuseppe Colombo, Maurizio Colecchia, Lucia Ferrari, Giorgio Guazzoni, Andrea Conti, Giario Conti, Roberta Lucianò, Tiziana Magnani, Renzo Colombo
BACKGROUND: When treating bladder cancer patients, the most significant problems usually concern cases with high-grade non-muscle-invasive carcinoma, and a better understanding of which patients would benefit from early radical cystectomy is urgently needed. The uropathology community is seeking more user-friendly approaches to distinguishing between T1 cancers exhibiting different types of clinical behavior. METHODS: After a retrospective review, we selected a group of 314 patients who underwent transurethral resection of the bladder (TURB) and were diagnosed with high-grade urothelial carcinoma staged as T1...
January 20, 2016: Diagnostic Pathology
https://www.readbyqxmd.com/read/26612603/micrornas-in-bladder-outlet-obstruction-relationship-to-growth-and-matrix-remodelling
#11
REVIEW
Mari Ekman, Sebastian Albinsson, Bengt Uvelius, Karl Swärd
The discovery of microRNAs (miRNAs), which are ~22 nucleotide RNAs that inhibit protein synthesis in a sequence-specific manner and are present in a range of species, has born hope of new therapeutic strategies. miRNAs play important roles in development and disease, but they remain poorly studied in uropathologies beyond cancer. Here, we discuss biological functions of miRNAs in the lower urogenital tract. A special focus is on miRNAs that change in bladder outlet obstruction (BOO). This is a condition that affects nearly one third of all men over 60 years and that involves growth and fibrosis of the urinary bladder...
October 2016: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/26542701/-report-of-the-working-group-on-uropathology-of-the-german-society-of-pathology-2015
#12
R Knüchel-Clarke, A Hartmann
No abstract text is available yet for this article.
November 2015: Der Pathologe
https://www.readbyqxmd.com/read/26494473/-erratum-to-cytology-in-uropathological-diagnostics
#13
N T Gaisa, K Lindemann-Docter
No abstract text is available yet for this article.
November 2015: Der Pathologe
https://www.readbyqxmd.com/read/26490556/the-potential-repertoire-of-the-innate-immune-system-in-the-bladder-expression-of-pattern-recognition-receptors-in-the-rat-bladder-and-a-rat-urothelial-cell-line-myp3-cells
#14
Francis M Hughes, David P Turner, J Todd Purves
PURPOSE: The urothelium is a frontline sensor of the lower urinary tract, sampling the bladder lumen and stimulating an immune response to infectious and noxious agents. Pattern recognition receptors (PRRs) recognize such agents and coordinate the innate response, often by forming inflammasomes that activate caspase-1 and the release of interleukin-1. We have shown the presence of one PRR (NLRP3) in the urothelia and its central role in the inflammatory response to cyclophosphamide. The purpose of this study was to (1) assess the likely range of the PPR response by assessing the repertoire present in the rat bladder and (2) determine the utility of the MYP3 rat urothelia cell line for in vitro studies by assessing its PPR repertoire and functional responsiveness...
December 2015: International Urology and Nephrology
https://www.readbyqxmd.com/read/26362326/-cytology-in-uropathological-diagnostics
#15
REVIEW
N T Gaisa, K Lindemann-Docter
Cytology in uropathological diagnostics is mainly performed for oncological purposes. The assessment of malignancy by urothelial cell morphology is therefore decisive; however, cytology is only sensitive enough to detect high-grade tumor cells and the different low-grade tumors cannot be reliably diagnosed. Thus, the four-tier classification system of cytological findings (i.e. negative, atypical cells but significance uncertain, suspicious and positive) refers to high-grade tumor cells only. Furthermore, for valid cytological diagnostics not only the cytological specimen but also clinical information on cystoscopy findings and, if applicable, a biopsy should be evaluated together...
November 2015: Der Pathologe
https://www.readbyqxmd.com/read/26260531/is-transperineal-prostate-biopsy-more-accurate-than-transrectal-biopsy-in-determining-final-gleason-score-and-clinical-risk-category-a-comparative-analysis
#16
COMPARATIVE STUDY
Susan Scott, Hemamali Samaratunga, Charles Chabert, Michelle Breckenridge, Troy Gianduzzo
OBJECTIVES: To assess the degree of upgrading and increase in clinical risk category of transperineal template biopsy (TTB) compared with transrectal ultrasonography-guided prostate biopsy (TRUSB). Upgrading of TRUSB Gleason grade and sum after radical prostatectomy (RP) is well recognised. TTB may offer a more thorough mapping of the prostate than TRUSB, as well as a more accurate assessment of the tumour. In this retrospective cohort study of prospectively collected data, we compare the initial TRUSB and TTB Gleason grade and sum with the final assessment at RP...
October 2015: BJU International
https://www.readbyqxmd.com/read/26211928/pleomorphic-giant-cell-carcinoma-of-the-urinary-bladder-an-extreme-form-of-tumour-de-differentiation
#17
Hemamali Samaratunga, Brett Delahunt, Lars Egevad, Michael Adamson, David Hussey, Greg Malone, Kirsten Hoyle, Tim Nathan, David Kerle, Peter Ferguson, John N Nacey
AIMS: Vesical pleomorphic giant cell carcinoma (PGCC) is a variant of urothelial carcinoma (UC) characterized by highly pleomorphic tumour with giant cells. Fewer than 10 cases have been reported, and our aim was to determine the clinical and pathological features of a series of tumours from a specialized uropathology laboratory. METHODS AND RESULTS: Thirteen cases of PGCC of the bladder were identified. There were nine males and four females, ranging in age from 53 to 92 years (mean 72 years)...
March 2016: Histopathology
https://www.readbyqxmd.com/read/26166668/the-effects-of-instrumentation-on-urine-cytology-and-ck-20-analysis-for-the-detection-of-bladder-cancer
#18
Olivier Wegelin, Diny W M Bartels, Ellen Tromp, Karel C Kuypers, Harm H E van Melick
OBJECTIVE: To evaluate the effects of cystoscopy on urine cytology and additional cytokeratin-20 (CK-20) staining in patients presenting with gross hematuria. PATIENTS AND METHODS: For 83 patients presenting with gross hematuria, spontaneous and instrumented paired urine samples were analyzed. Three patients were excluded. Spontaneous samples were collected within 1 hour before cystoscopy, and the instrumented samples were tapped through the cystoscope. Subsequently, patients underwent cystoscopic evaluation and imaging of the urinary tract...
October 2015: Urology
https://www.readbyqxmd.com/read/26072631/value-of-frozen-sections-in-uropathology
#19
REVIEW
Ferran Algaba
The indications of frozen section diagnosis in uropathology are quite specific, and this explains the fact that they amount to a mere 7.3% of the frozen sections performed in general hospitals. Generally speaking, frozen sections are not warranted to identify the nature of a tumoral mass, with the following exceptions: (1) renal masses of a doubtful parenchymal origin or located in the urinary tract, (2) testicular neoplasias, when the possibility of a conservative treatment arises, and (3) determination of the presence of a prostate adenocarcinoma in an organ donor with high serum prostate-specific antigen (but even in these circumstances the need is widely controversial)...
February 2015: Analytical and Quantitative Cytopathology and Histopathology
https://www.readbyqxmd.com/read/25886613/long-term-outcome-of-primary-papillary-urothelial-neoplasm-of-low-malignant-potential-punlmp-including-punlmp-with-inverted-growth
#20
Jay P Maxwell, Cheng Wang, Nicholas Wiebe, Asli Yilmaz, Kiril Trpkov
BACKGROUND: Few larger studies have evaluated the long-term outcome after a diagnosis of papillary urothelial neoplasm of low malignant potential (PUNLMP), demonstrating a broad range of recurrence and progression rates. Additionally, no study has addressed the outcome of PUNLMP exhibiting inverted growth. We evaluated the long term clinical outcome of primary papillary urothelial neoplasm of low malignant potential (PUNLMP), including PUNLMP with inverted growth in a large single center study...
2015: Diagnostic Pathology
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