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Immunohaematology

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https://www.readbyqxmd.com/read/27698601/the-management-of-transfusion-services-analysis-and-assessment
#1
Dzenana Begic, Ermina Mujicic, Jozo Coric, Lejla Zunic
INTRODUCTION: The hospital blood bank (HBB) need to timely provide adequate amounts of blood and blood products for surgeries. For various surgical programs are performed assessments of the average number of blood doses needed for surgery. By using two types of requisitions BT/AB (blood type/antibody) and BT/AB/MT (blood type/antibody/match test) for pretransfusion immunohaematological testing in General Hospital "Prim. Dr. Abdulah Nakas" is achieved more rational consumption of blood and blood derivatives and financial savings through reduced number of matching tests (MT)...
July 24, 2016: Materia Socio-medica
https://www.readbyqxmd.com/read/27580632/single-molecule-fluorescence-microscopy-and-machine-learning-for-rhesus-d-antigen-classification
#2
Daniela M Borgmann, Sandra Mayr, Helene Polin, Susanne Schaller, Viktoria Dorfer, Lisa Obritzberger, Tanja Endmayr, Christian Gabriel, Stephan M Winkler, Jaroslaw Jacak
In transfusion medicine, the identification of the Rhesus D type is important to prevent anti-D immunisation in Rhesus D negative recipients. In particular, the detection of the very low expressed DEL phenotype is crucial and hence constitutes the bottleneck of standard immunohaematology. The current method of choice, adsorption-elution, does not provide unambiguous results. We have developed a complementary method of high sensitivity that allows reliable identification of D antigen expression. Here, we present a workflow composed of high-resolution fluorescence microscopy, image processing, and machine learning that - for the first time - enables the identification of even small amounts of D antigen on the cellular level...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27372209/understanding-the-silver-book-an-important-reference-for-standardised-nomenclature-in-clinical-laboratory-sciences
#3
Robert Flatman, Georges Férard, René Dybkaer
Clinical laboratories perform a wide menu of testing (examinations). Successful requesting, examination, and ordering in this environment requires clear standardised nomenclature. The Silver Book (SB) is an IUPAC (International Union of Pure and Applied Chemistry) publication, produced with the support of both IUPAC and the IFCC (International Federation of Clinical Chemistry and Laboratory Medicine), that makes recommendations on logical standardised nomenclature, symbols, properties, and units in many disciplines of the clinical laboratory sciences...
June 29, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/26820615/aisf-simti-position-paper-the-appropriate-use-of-albumin-in-patients-with-liver-cirrhosis
#4
Paolo Caraceni, Paolo Angeli, Daniele Prati, Mauro Bernardi, Giancarlo M Liumbruno, Francesco Bennardello, Pierluigi Piccoli, Claudio Velati
The use of human albumin is common in hepatology since international scientific societies support its administration to treat or prevent severe complications of cirrhosis, such as the prevention of post-paracentesis circulatory dysfunction after large-volume paracentesis and renal failure induced by spontaneous bacterial peritonitis, and the treatment of hepatorenal syndrome in association with vasoconstrictors. However, these indications are often disregarded, mainly because the high cost of human albumin leads health authorities and hospital administrations to restrict its use...
January 2016: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/26802734/aisf-simti-position-paper-the-appropriate-use-of-albumin-in-patients-with-liver-cirrhosis
#5
REVIEW
(no author information available yet)
The use of human albumin is common in hepatology since international scientific societies support its administration to treat or prevent severe complications of cirrhosis, such as the prevention of post-paracentesis circulatory dysfunction after large-volume paracentesis and renal failure induced by spontaneous bacterial peritonitis, and the treatment of hepatorenal syndrome in association with vasoconstrictors. However, these indications are often disregarded, mainly because the high cost of human albumin leads health authorities and hospital administrations to restrict its use...
January 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/26710354/molecular-immunohaematology-round-table-discussions-at-the-aabb-annual-meeting-philadelphia-2014
#6
Willy A Flegel, Shirley L De Castilho, Margaret A Keller, Ellen B Klapper, Joann M Moulds, France Noizat-Pirenne, Nadine Shehata, Gary Stack, Maryse St-Louis, Christopher A Tormey, Dan A Waxman, Christof Weinstock, Silvano Wendel, Gregory A Denomme
No abstract text is available yet for this article.
September 2016: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/26494376/hygiene-monitoring-in-a-hospital-immunohaematological-laboratory
#7
E Strobel, P Gleich
PURPOSE OF THE STUDY: Not only in blood donation services, but also in the immunohaematological laboratory of a hospital including the depository for blood products a hygiene plan must be drawn up and its realization has to be documented. MATERIAL AND METHODS: From 2011 to 2014, some equipment in the depository and in the immunohematological laboratory was microbiologically monitored once a year. The examinations were done by direct contact cultures taken from several places of each device...
October 2015: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/26428758/observed-full-blood-count-and-lymphocyte-subset-values-in-a-cohort-of-clinically-healthy-south-african-children-from-a-semi-informal-settlement-in-cape-town
#8
Denise Lawrie, Helen Payne, Martin Nieuwoudt, Deborah Kim Glencross
BACKGROUND: The paediatric full blood count and lymphocyte subset reference intervals used by the National Health Laboratory Service (NHLS), South Africa (SA), are taken from two international reference interval publications. Differences in reference intervals suggest that international data sets may not be appropriate for use in SA. OBJECTIVE: To study immunohaematological values of a group of clinically healthy children from an informal settlement in Cape Town, SA, to assess whether international paediatric reference intervals used by the NHLS are appropriate...
September 21, 2015: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/26219314/acute-transfusion-reactions-encountered-in-patients-at-a-tertiary-care-centre-in-punjab
#9
Manvi Gupta, Rajesh Kumar, Sonia Gupta, Amarjit Kaur
BACKGROUND: Blood transfusion is a life-saving procedure, which can occasionally be unsafe and result in a spectrum of adverse events. We aimed to determine the characteristics and type of acute transfusion reactions occurring in patients at a tertiary care centre. METHODS: A retrospective study was conducted at the Department of Immunohaematology and Blood Transfusion, Dayanand Medical College and Hospital, Ludhiana, Punjab. All acute transfusion reactions reported to the department from 1 Jan 2012 to 31 March 2013 were evaluated...
January 2015: National Medical Journal of India
https://www.readbyqxmd.com/read/26033335/anti-d-alloimmunisation-in-pregnant-women-with-del-phenotype-in-china
#10
M Wang, B L Wang, W Xu, D D Fan, M L Peng, J Pan, P Yao, G M Jiang, X J Wan
OBJECTIVES: To analyse anti-D alloimmunisation in pregnant women with D-elute (DEL) phenotype in China, for developing a predictive model to evaluate whether a person with the DEL phenotype can receive RhD-positive blood. BACKGROUND: Alloanti-D acquired by pregnancy or transfusion is one of the major causes of both haemolytic disease among newborns and haemolytic transfusion reactions. To date, there is little data available about the antigenic properties and immunogenicity of extremely weak D variants known as DEL...
June 2015: Transfusion Medicine
https://www.readbyqxmd.com/read/25967919/how-we-treat-delayed-haemolytic-transfusion-reactions-in-patients-with-sickle-cell-disease
#11
REVIEW
Kate Gardner, Carolyn Hoppe, Aleksandar Mijovic, Swee L Thein
Transfusion therapy is effective in the prevention and treatment of many complications of sickle cell disease (SCD). However, its benefits must be balanced against its risks, including delayed haemolytic transfusion reactions (DHTR). Not only is the relative rate of alloimmunization higher in patients with SCD than in other patient populations, but attendant risks associated with DHTR are even greater in SCD. Clinicians' awareness of DHTR events is poor because symptoms of DHTR mimic acute vaso-occlusive pain and immunohaematology findings are often negative...
September 2015: British Journal of Haematology
https://www.readbyqxmd.com/read/25633877/recommendations-for-the-prevention-and-treatment-of-haemolytic-disease-of-the-foetus-and-newborn
#12
Francesco Bennardello, Serelina Coluzzi, Giuseppe Curciarello, Tullia Todros, Stefania Villa
No abstract text is available yet for this article.
January 2015: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/25545874/molecular-immunohaematology-round-table-discussions-at-the-aabb-annual-meeting-denver-2013
#13
Willy A Flegel, Lilian Castilho, Meghan Delaney, Ellen B Klapper, Joann M Moulds, France Noizat-Pirenne, Nadine Shehata, Gary Stack, Christopher A Tormey, Franz F Wagner, Dan A Waxman, Christof Weinstock, Silvano Wendel, Gregory A Denomme
No abstract text is available yet for this article.
July 2015: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/25458984/-clinico-biological-and-immunohaematological-profile-of-patients-with-%C3%AE-thalassemia-in-tunisia-about-26-cases
#14
H Romdhane, H Amara, S Abdelkefi, N Souyeh, T Chakroun, I Jarrey, M Bouslama, S Belhedi, B Houissa, L Boughammoura, S Jemni Yacoub
AIM OF THE STUDY: To study the clinical and biological profile of β-thalassemic patients in our region, reflecting the quality of their care. PATIENTS AND METHODS: A retrospective study (2010-2011) on 26 β-thalassemic patients followed in the pediatrics service at CHU Farhat Hached Sousse, Tunisia. Epidemiological, clinical and biological data were collected from medical records and transfusion files of patients. The transfusion protocol adopted was to maintain a hemoglobin level>10g/dL by regular transfusions every 3-4 weeks...
December 2014: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/25053927/farewell-to-prof-dr-dr-walter-sibrowski
#15
Gregor Bein, Harald Klüter
No abstract text is available yet for this article.
June 2014: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/24948207/-association-of-red-blood-cell-and-platelet-allo-antibodies-in-platelet-alloimmunized-patients
#16
P Moncharmont, D Rigal
PURPOSE OF THE STUDY: Use of matched red blood cell (RBC) concentrates is imperative in patients with RBC allo-antibodies (Abs) and when platelet (PLT) specific allo-Abs are present additional difficulties occur for PLT transfusions. In order to evaluate the prevalence of the PLT and RBC allo-Abs association, a study on patients with PLT specific allo-Acs was performed. This association is not a rare event. PATIENTS AND METHODS: In the database of a PLT immunohaematology laboratory, patients with PLT specific allo-Abs were selected and the presence and specificity of RBC allo-Abs was evaluated...
June 2014: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/24619312/haemoglobin-levels-in-autoimmune-haemolytic-anaemias-at-diagnosis-relationship-with-immunoproteins-on-red-blood-cells
#17
Marco Lai, Valerio De Stefano, Raffaele Landolfi
Previous investigations of the relationship between characteristics of immunoproteins on red blood cells (RBCs) and the occurrence of autoimmune haemolysis yielded divergent results. Here, we studied these characteristics in autoimmune haemolytic anaemias (AIHAs) to determine their relationship with the degree of anaemia at diagnosis. We studied at diagnosis 52 cases of warm AIHA with positive direct antiglobulin test. Immunohaematological testing and determination of immunoglobulin class, complement, and immunoglobulin G (IgG) were performed using gel technology (GCT)...
October 2014: Immunologic Research
https://www.readbyqxmd.com/read/24581247/rare-coagulation-factor-deficiencies-a-countrywide-screening-data-from-india
#18
S Shetty, T Shelar, D Mirgal, V Nawadkar, P Pinto, S Shabhag, A Mukaddam, B Kulkarni, K Ghosh
As compared to haemophilia, although the clinical features and the management strategies for rare coagulation factor deficiencies are discussed, little is known about them. This study was undertaken to assess the distribution, clinical presentation and treatment of patients with rare coagulation factor deficiency disorders in a cross-sectional population of India. Blood samples and other clinical details from patients suspected of rare coagulation factor deficiencies were collected by the Haemophilia Treatment Centers across India and were diagnosed at National Institute of Immunohaematology, Mumbai...
July 2014: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/24333058/molecular-immunohaematology-round-table-discussions-at-the-aabb-annual-meeting-boston-2012
#19
Willy A Flegel, Susan T Johnson, Margaret A Keller, Ellen B Klapper, Hanh M Khuu, Joann M Moulds, Axel W Seltsam, Gary Stack, Maryse St-Louis, Christopher A Tormey, Franz F Wagner, Christof Weinstock, Mark H Yazer, Gregory A Denomme
No abstract text is available yet for this article.
April 2014: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/24188135/evaluation-of-erytra%C3%A2-fully-automated-analyser-for-routine-use-in-transfusion-laboratory
#20
COMPARATIVE STUDY
C Chang, M Brown, L Davies, L Pointon, R Brown, D Barker
OBJECTIVE: To evaluate efficiency and performance of Erytra® analyser in comparison to the reference platform of the NBT immunohaematology laboratory (Bio-Rad ID-System). BACKGROUND: Moving to automation or semi-automation is a major focus of transfusion centres. The Erytra® (Grifols) is a new fully automated walk-away analyser with high volume processing capacity for pre-transfusion testing, designed to be used with the unique 8-column DG Gel® cards. STUDY DESIGN AND METHODS: A total of 2201 immunohaematological tests (1041 ABO/D grouping, 1041 antibody screening, 51 antibody identification, 45 newborns (ABO/D and DAT) and 23 crossmatches were performed on 1160 donor/patient whole blood samples...
February 2014: Transfusion Medicine
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