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erythema multiforme

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https://www.readbyqxmd.com/read/29900900/erythema-nodosum-leprosum-presenting-as-sweet-s-syndrome-like-reaction-in-a-borderline-lepromatous-leprosy-patient
#1
Nyoman Suryawati, Herman Saputra
Erythema nodosum leprosum (ENL) is characterized by tender erythematous nodules, accompanied by fever, malaise, arthralgia, and systemic complications. Atypical clinical manifestations have been reported such as pustular, bullous, ulceration; livedo reticularis; erythema multiforme-like reaction; and Sweet's syndrome (SS)-like presentation. We reported a case of ENL reaction presenting as SS-like reaction in a borderline lepromatous leprosy patient.
April 2018: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29900896/leprosy-in-northwest-louisiana-a-case-series
#2
Andrew Stevenson Joel Chandranesan, Pradeep Kumar Mada, Frances Ramos-Herberth, David Walsworth, Robert Penn, Ronald Washburn
Hansen's disease, commonly known as leprosy, is a chronic mycobacterial infection caused by Mycobacterium leprae. Although generally uncommon in the United States, it is endemic in the Southern United States. We diagnosed and managed five leprosy patients from Northwest Louisiana, each presenting a distinct set of challenges. A retrospective study was performed to collect demographic, clinical, and laboratory data from our cases. The information was analyzed with a specific focus on associated factors, diagnosis, and management...
April 2018: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29766553/erythema-multiforme-after-orf-virus-infection
#3
Angella López-Cedeño, Gustavo Cañedo, Nicole Knöpfel, Isabel Colmenero, Esperanza Pérez-Pastrana, Antonio Torrelo
The case of a 6-year-old boy with multiple, target-shaped lesions and a crusted nodule on his right index finger is presented. Based on clinical findings and the patient's recent contact with sheep and goats, a diagnosis of orf disease associated with erythema multiforme was suspected. Microscopy studies confirmed the presence of parapoxvirus in the primary lesion. Orf-induced erythema multiforme is a rare complication of orf in children, possibly related to the presence of orf virus DNA in erythema multiforme lesions...
May 15, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29693054/atypical-still-disease-with-necrotic-keratinocytes-a-histologic-mimicker-of-erythema-multiforme
#4
Trisha Khanna, Christine C Yang, Tarek Yamany, David N Silvers, Christine T Lauren, Jesse M Lewin
No abstract text is available yet for this article.
May 2018: JAAD Case Reports
https://www.readbyqxmd.com/read/29676708/-urticaria-multiforme-difficult-to-distinguish-from-other-skin-conditions
#5
L Zijp, P M J H Kemperman, G W den Tusscher
BACKGROUND: Urticaria multiforme is a rare clinical variant of urticaria that occurs specifically in children. CASE DESCRIPTION: A boy aged 11 months was presented at the Emergency Department with acute onset of itching urticarial skin weals and acral oedema. This picture is consistent with the diagnosis of urticaria multiforme. CONCLUSION: The diagnosis of urticaria multiforme can be made on the basis of the clinical picture. Treatment is symptomatic and in most cases this condition resolves spontaneously within two weeks...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29610831/association-of-hla-a-31-01-screening-with-the-incidence-of-carbamazepine-induced-cutaneous-adverse-reactions-in-a-japanese-population
#6
Taisei Mushiroda, Yukitoshi Takahashi, Teiichi Onuma, Yoshiaki Yamamoto, Tetsumasa Kamei, Tohru Hoshida, Katsuya Takeuchi, Kotaro Otsuka, Mitsutoshi Okazaki, Masako Watanabe, Kosuke Kanemoto, Tomohiro Oshima, Atsushi Watanabe, Shiro Minami, Kayoko Saito, Hisashi Tanii, Yasushi Shimo, Minoru Hara, Shinji Saitoh, Toshihiko Kinoshita, Masaki Kato, Naoto Yamada, Naoki Akamatsu, Toshihiko Fukuchi, Shigenobu Ishida, Shingo Yasumoto, Atsushi Takahashi, Takeshi Ozeki, Takahisa Furuta, Yoshiro Saito, Nobuyuki Izumida, Yoko Kano, Tetsuo Shiohara, Michiaki Kubo
Importance: Carbamazepine, a commonly used antiepileptic drug, is one of the most common causes of cutaneous adverse drug reactions (cADRs) worldwide. The allele HLA-A*31:01 is reportedly associated with carbamazepine-induced cADRs in Japanese and European populations; however, the clinical utility of HLA-A*31:01 has not been evaluated. Objective: To assess the use of HLA-A*31:01 genetic screening to identify Japanese individuals at risk of carbamazepine-induced cADRs...
April 2, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29607753/histopathology-of-cutaneous-inflammatory-disorders-in-children
#7
Andy C Hsi, Ilana S Rosman
Inflammatory dermatoses encompass a variety of histologic patterns that affect different portions of the skin. In spongiotic, psoriasiform, lichenoid, pityriasiform, and blistering disorders, there are predominately epidermal and junctional activities with variable superficial dermal inflammation. Hypersensitivity reactions can show either epidermal or mostly dermal changes depending on whether the exposure of the exogenous allergen occurs through an external or internal route, respectively. Exceptions include erythema multiforme and Stevens-Johnson syndrome/toxic epidermal necrolysis, where the etiology is often due to infection or ingested medications, but the histologic features are almost exclusively confined to the epidermis and dermoepidermal junction...
March 2018: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/29599668/selected-presentations-of-lip-enlargement-clinical-manifestation-and-differentiation
#8
REVIEW
Katarzyna J Błochowiak, Bartłomiej Kamiński, Henryk Witmanowski, Jerzy Sokalski
Lip enlargement may be an important symptom of either systemic or local diseases. On the basis of selected age-matched clinical cases we present the possible causes of lip swelling. We describe the most representative symptoms and recommend treatment of these pathologies. We differentiate lip swelling in Miescher syndrome, monosymptomatic form of Melkersson-Rosenthal syndrome, lip swelling in erythema multiforme and Stevens-Johnson syndrome and lip hemangioma and mucous extravasation cyst. We compare different causes of lip edema and indicate the most helpful diagnostic and treatment methods...
February 2018: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29582465/tularemia-induced-erythema-multiforme-minor-in-an-11-year-old-girl
#9
Sarah J Coates, Benjamin Briggs, Kelly M Cordoro
Tularemia is a rare and potentially life-threatening infection caused by the highly infectious gram-negative coccobacillus Francisella tularensis. We present the case of an 11-year old girl who presented with erythema multiforme minor in the setting of an indolent but progressive soft tissue infection and was found to have tularemia. We review the role of dermatologists in identifying the features of and complications associated with this rare zoonosis and discuss the potential effect of climate change on its incidence...
March 26, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29559400/clinical-and-histologic-features-of-mycoplasma-pneumoniae-related-erythema-multiforme-a-single-center-series-of-33-cases-compared-with-100-cases-induced-by-other-causes
#10
Reyhan Amode, Saskia Ingen-Housz-Oro, Nicolas Ortonne, Touda Bounfour, Sabine Pereyre, Frédéric Schlemmer, Emilie Bequignon, Gérard Royer, Pierre Wolkenstein, Olivier Chosidow
BACKGROUND: Mycoplasma pneumoniae infection has been documented in erythema multiforme (EM) and Stevens-Johnson syndrome-toxic epidermal necrosis (SJS-TEN). Clinical aspects of M pneumoniae-related EM have been poorly described in the literature. OBJECTIVE: To highlight differences between M pneumoniae EM and non-M pneumoniae EM. METHODS: This single-center, retrospective cohort study included all patients admitted to our dermatology department for EM during 2000-2015...
March 17, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29554163/smallpox-vaccine-complications-the-dermatologist-s-role-in-diagnosis-and-management
#11
Janelle Robertson, Jason Susong, Emily B Wong
In 2002, the United States implemented a new program for smallpox vaccinations among military personnel using a live vaccinia virus product. Approximately 2.4 million US military service members and health care workers have since been inoculated, with considerable numbers experiencing adverse reactions. Military dermatologists are at the forefront of describing and treating these reactions, from relatively benign generalized vaccinia (GV) and erythema multiforme (EM) to more severe progressive vaccinia (PV) and eczema vaccinatum (EV)...
February 2018: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29516895/reactive-perforating-leprosy-erythema-multiforme-like-reactions-sweet-s-syndrome-like-reactions-as-atypical-clinical-manifestations-of-type-2-leprosy-reaction
#12
Hendra Gunawan, Yuri Yogya, Risty Hafinah, Rachel Marsella, Devi Ermawaty, Oki Suwarsa
Type 2 leprosy reactions commonly known as erythema nodosum leprosum, but various clinical manifestations of type 2 leprosy reaction were exist. The highlight of this case series was to report various atypical clinical manifestations of type 2 leprosy reaction such as reactive perforating leprosy, erythema multiforme-like reaction, and sweet's syndrome (SS)-like reaction.
January 2018: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29515387/a-case-of-erythema-multiforme-major-developed-after-sequential-use-of-two-immune-checkpoint-inhibitors-nivolumab-and-ipilimumab-for-advanced-melanoma-possible-implication-of-synergistic-and-or-complementary-immunomodulatory-effects
#13
Akira Utsunomiya, Noritaka Oyama, Shiro Iino, Natsuki Baba, Takenao Chino, Natsuko Utsunomiya, Minoru Hasegawa
Immune checkpoint inhibitors, such as ipilimumab and nivolumab, reverse the imbalance of antitumor self-tolerance and enhance T-cell responses. Currently, ipilimumab and nivolumab have a reported therapeutic impact on unresectable or metastatic melanomas; however, they also induce immune-related adverse events (irAEs). Ipilimumab-induced cutaneous irAEs are mostly low grade and manageable, although all-grade rash may occur in approximately 45% of all patients. We here report the case of a young woman with erythema multiforme major, which developed after sequential use of these 2 immune checkpoint inhibitors for advanced melanoma of the scalp...
January 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29483990/segmental-erythema-multiforme-like-drug-eruption-by-aromatase-inhibitor-anastrozole-first-case-report-and-another-example-of-an-immunocompromised-district
#14
Uwe Wollina, Jacqueline Schönlebe, Birgit Heinig, Georgi Tchernev, Katlein França, Torello Lotti
Anastrozole is a non-selective aromatase inhibitor for adjuvant breast cancer therapy in postmenopausal women. Cutaneous adverse events have been reported. We observed a 64-year-old female patient with a medical history of locally advanced breast cancer of her right breast that was treated with radiotherapy and adjuvant drug therapy with anastrozole. She developed a segmental bullous eruption limited to the cancer-affected breast. Cessation of the aromatase inhibitor and systemic therapy with prednisolone cleared the lesions completely...
January 25, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29483433/-a-case-of-metastatic-colorectal-cancer-with-brain-metastasis-treated-with-combined-tftd-and-bevacizumab-therapy
#15
Jin Takano, Nobuhisa Matsuhashi, Takao Takahashi, Toshiyuki Tanahashi, Satoshi Matsui, Hisashi Imai, Yoshihiro Tanaka, Kazuya Yamaguchi, Kazuhiro Yoshida
A woman in her 70s was confirmed as presenting with multiple liver and lung metastases from transverse colon cancer. After undergoing resection of the primary lesion, partial response(PR)was achieved after undergoing the first regimen (sLV5FU2 and bevacizumab[Bmab]); therefore, partial hepatectomy was performed. Adjuvant chemotherapy was administered for 7 months, but liver metastasis recurrence, multiple lung metastases, and brain metastasis were confirmed. As the brain metastasis was a single lesion and was accompanied by symptoms, resection of the lesion was performed...
February 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29469784/a-case-of-erythema-multiforme-major-following-administration-of-ciprofloxacin-ophthalmic-drops
#16
Morgan Arnold, Michael Wilkerson
A 49-year old woman was hospitalized for generalized rash and pruritus following the administration of ophthalmic drops containing ciprofloxacin to treat conjunctivitis. Physical examination demonstrated diffuse erythematous papules and plaques with a targetoid appearance, injected sclera, and multiple erosions in the oropharynx. Skin biopsy confirmed a diagnosis of erythema multiforme major. The eye drops were discontinued and supportive treatment was initiated; the patient recovered in four weeks and was discharged from the hospital...
October 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469759/vaccine-induced-toxic-epidermal-necrolysis-a-case-and-systematic-review
#17
Dev Chahal, Maria Aleshin, Mamina Turegano, Melvin Chiu, Scott Worswick
BACKGROUND: Erythema multiforme (EM), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are cutaneous hypersensitivityreactions that develop in response to specific triggers such as medications and certain infections. Vaccines, which undergo rigorous safety testing prior to use in humans, are a rare cause of SJS/TEN and little is known about the frequency of such events and corresponding pathogenesis. OBJECTIVE: Herein, we discuss a case of suspected TEN in a 19-year-old woman who received the meningococcal B vaccine (the first report of such an association) and conduct a systematic review of the associated literature...
January 15, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469720/erythema-multiforme-major-in-a-patient-with-metastatic-melanoma-treated-with-nivolumab
#18
Swami Sundaresan, Kathleen T Nguyen, Kelly C Nelson, Doina Ivan, Anisha B Patel
Nivolumab, a relatively novel immune checkpoint inhibitor with FDA approval in 2014, is gaining greater utilization due to its efficacy in treating metastatic melanoma. Many of the cutaneous immune-related adverse events (irAEs) being catalogued do not necessitate discontinuation of immunotherapy and are managed with supportive therapy. We present a case of erythema multiforme major secondary to nivolumab requiring hospitalization and discontinuation of treatment. This is only the second reported case of nivolumab-induced erythema multiforme in the literature we are aware of, and emphasizes the importance of oncologists working in conjunction with dermatologists for prompt diagnosis and management...
September 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29463113/pediatric-lip-adhesion-following-bullous-erythema-multiforme-and-review-of-similar-oral-complications
#19
Rosalind Ashton, Karen W Wong, Miriam Weinstein
BACKGROUND: Erythema multiforme (EM) is a mucocutaneous disease most often associated with preceding herpes simplex virus or Mycoplasma pneumoniae infection. It is characterized by targetoid lesions occurring on the limbs and head and neck. Mucosal involvement can be extensive. OBJECTIVE: We report a case of lip adhesion as a complication of EM in a child who required corrective surgery and review similar oral commissure complications. METHODS: We completed a review of the literature for similar cases using PubMed and Medline...
February 1, 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29450445/lenalidomide-as-an-alternative-to-thalidomide-for-treatment-of-recurrent-erythema-multiforme
#20
Faustine Drahy, Saskia Ingen-Housz-Oro, Sabine Grootenboer-Mignot, Pierre Wolkenstein, Olivier Chosidow
No abstract text is available yet for this article.
April 1, 2018: JAMA Dermatology
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