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erythema multiforme

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https://www.readbyqxmd.com/read/27868144/paediatric-erythema-multiforme-epidemiological-clinical-and-laboratory-characteristics
#1
Yael Siedner-Weintraub, Itai Gross, Almog David, Shimon Reif, Vered Molho-Pessach
Erythema multiforme (EM) is an immune-mediated reaction presenting as acrofacial target lesions. Most studies utilize the outdated classification, which includes EM, Stevens-Johnson syndrome and toxic epidermal necrolysis as related entities. We describe here epidemiological, aetiological, clinical, laboratory and treatment characteristics of paediatric EM. This is a retrospective single-centre study, performed between 2000 and 2013. Of 119 children given a diagnosis of EM, only 30 met clinical criteria and were included in this study...
November 10, 2016: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/27862162/erythema-multiforme-like-cutaneous-lesions-in-monomorphic-epitheliotropic-intestinal-t-cell-lymphoma-a-rare-case-report
#2
Kumpol Aiempanakit, Chitiarpa Amatawet, Kanokphorn Chiratikarnwong, Sauvarat Auepemkiate, Kanita Kayasut, Supaporn Suwiwat, Benjawan Apinantriyo
Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL), also known as Type II enteropathy-associated T-cell lymphoma (EATL), is an aggressive peripheral T-cell lymphoma. EATL generally presents in adults with gastrointestinal symptoms. Skin involvement is very rare, found only in approximately five percent of patients. The authors report a 67-year-old Asian male who presented with chronic diarrhea and developed erythema multiforme-like cutaneous lesions. A skin biopsy revealed extensive pagetoid spread of atypical lymphocytes in the epidermis...
November 10, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27860166/treatment-of-antiviral-resistant-recurrent-erythema-multiforme-with-dapsone
#3
Allen S W Oak, Lucia Seminario-Vidal, Naveed Sami
Recurrent erythema multiforme (REM) is a chronic disease characterized by frequent episodes of target cutaneous lesions in an acral distribution. Conventional treatment includes systemic corticosteroids and antiviral therapy. The aim of this study was to evaluate dapsone as a potential steroid sparing-agent for the treatment of REM after a failed trial of at least one antiviral therapy (acyclovir, famciclovir, or valacyclovir). A retrospective chart review was conducted on thirteen patients with a diagnosis of REM who underwent treatment with dapsone after failing at least one antiviral therapy...
November 18, 2016: Dermatologic Therapy
https://www.readbyqxmd.com/read/27847401/treatment-of-a-pregnant-patient-with-herpes-associated-erythema-multiforme-haem-a-case-report
#4
Kobkan Thongprasom
Erythema Multiforme, (EM) is an uncommon, acute inflammatory disease of the skin and mucous membranes characterized by ulcerations caused by hypersensitivity to drugs, microbial agents or other allergens. An EM outbreak can result in more severe forms of EM involving the skin, and there are several types of EM manifestations. A hemorrhagic crust on the lip is a pathognomonic sign of this disease. Target lesions may or may not be present in EM cases. When target lesions are not present on the skin, it is very difficult to make a differential diagnosis of EM...
September 2016: Acta Stomatologica Croatica
https://www.readbyqxmd.com/read/27799135/drug-induced-cutaneous-lupus-erythematosus-88-new-cases
#5
Rasa Laurinaviciene, Linda Holm Sandholdt, Anette Bygum
BACKGROUND: An increasing number of drugs have been linked to drug-induced subacute cutaneous lupus erythematosus (DI-SCLE). The recognition and management of DI-SCLE can be challenging, as the condition may be triggered by different classes of drugs after variable lengths of time. OBJECTIVES: To determine the proportion of patients with cutaneous lupus erythematosus (CLE) whose drugs are an inducing or aggravating factor. MATERIALS & METHODS: We conducted a retrospective chart review of patients diagnosed with CLE at a dermatological department over a 21-year period...
October 31, 2016: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/27775965/erythema-multiforme-like-allergic-contact-dermatitis-to-turmeric-essential-oil
#6
Jordan Huber, Rosemary deShazo, Douglas Powell, Keith Duffy, Christopher Hull
No abstract text is available yet for this article.
October 21, 2016: Dermatitis
https://www.readbyqxmd.com/read/27757979/a-case-of-erythema-multiforme-drug-eruption-associated-with-erythrodermic-psoriasis-induced-by-sofosbuvir-and-daclatasvir
#7
Y Wang, P Liu
WHAT IS KNOWN AND THE OBJECTIVE: Sofosbuvir (SOF) and daclatasvir (DCV) have revolutionized the treatment of hepatitis C virus and now represent the preferred therapy for this disease. Limited data are available on the dermatological side effects resulting from co-administration of SOF and DCV. CASE DESCRIPTION: We report a case of an erythema multiforme drug eruption associated with erythrodermic psoriasis induced by SOF and DCV. After ceasing treatment, the skin condition significantly improved...
October 18, 2016: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/27757243/an-unexpected-rash-with-gastroenteritis-erythema-multiforme-associated-with-campylobacter-infection
#8
Joon Heng Tan, Liam Healy, Kristel Yap, Aditya Mandal
We present the first documented case of erythema multiforme following campylobacter gastroenteritis.
October 2016: JRSM Open
https://www.readbyqxmd.com/read/27723997/autoimmune-estrogen-dermatitis-in-an-infertile-female
#9
Gonce Elcin, Duygu Gülseren, Miyase Bayraktar, Serdar Gunalp, Timur Gurgan
Autoimmune estrogen dermatitis is a cyclical cutaneous eruption that occurs premenstrually and rapid resolution of the eruptions within a few days of menstrual cycles. The disorder has variable clinical manifestations consisting of macules, papules, vesicles, urticarial lesions, bullae, eczematous plaques, and erythema multiforme-like lesions. Herein, we present a case of a 30-year-old woman with attacks of edema and erosions involving the oral and genital mucosal sites on every first day of her menstruation period...
October 11, 2016: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/27663464/-childhood-postinfectious-erythema-multiforme
#10
M Larquey, E Mahé
Postinfectious erythema multiforme is an uncommon skin disease in childhood that can have a strong impact, especially in infants if there is involvement of the mucous membranes. The lesion is targeted (central bullous lesions with three concentric circles). Its diagnosis is typically made clinically. Atypical forms are the highly inflammatory, mainly bullous type, with exclusive involvement of the mucous membrane, or recurrent erythema multiforme. The diagnosis of erythema multiforme is frequently suspected in children with urticaria multiforme...
November 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/27617610/unusual-manifestation-of-mucosal-plasmacytosis-mimicking-erythema-multiforme
#11
Keshavamurthy Vinay, Chougule Abhijit, Sunil Dogra
Mucosal plasmacytoses constitute a group of idiopathic inflammatory disorders, characterized by a dense infiltrate of plasma cells at the mucocutaneous junction without any recognizable dermatosis or neoplasm. We report an unusual clinical presentation of mucosal plasmacytosis presenting with hemorrhagic crusting of the lips, mimicking erythema multiforme.
2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/27581387/apoptosis-as-a-mechanism-for-keratinocyte-death-in-canine-toxic-epidermal-necrolysis
#12
F Banovic, S Dunston, K E Linder, P Rakich, T Olivry
In humans and dogs, toxic epidermal necrolysis (TEN) is a life-threatening dermatosis characterized by sudden epidermal death resulting in extensive skin detachment. There is little information on the pathogenesis of keratinocyte cell death in canine TEN. We studied the occurrence of apoptosis in skin lesions of dogs with TEN to determine if apoptosis contributes to the pathogenesis of this disease. Immunostaining with antibodies to activated caspase-3 and the terminal deoxynucleotidyl-transferase (TdT)-mediated deoxyuridine triphosphate (dUTP) nick-end labeling technique revealed positive apoptotic keratinocytes in basal and suprabasal epidermal compartments in 17 biopsy specimens collected from 3 dogs with TEN and 16 from 3 dogs with erythema multiforme (EM)...
August 31, 2016: Veterinary Pathology
https://www.readbyqxmd.com/read/27565810/phase-ia-ib-study-of-the-pan-class-i-pi3k-inhibitor-pictilisib-gdc-0941-administered-as-a-single-agent-in-japanese-patients-with-solid-tumors-and-in-combination-in-japanese-patients-with-non-squamous-non-small-cell-lung-cancer
#13
Noboru Yamamoto, Yutaka Fujiwara, Kenji Tamura, Shunsuke Kondo, Satoru Iwasa, Yuko Tanabe, Atsushi Horiike, Noriko Yanagitani, Satoru Kitazono, Michiyasu Inatani, Jun Tanaka, Makoto Nishio
Pictilisib (GDC-0941) is an oral class I phosphatidylinositol-3-phosphate kinase inhibitor. This phase Ia/Ib study investigated the safety, tolerability, pharmacokinetics, and pharmacodynamics of pictilisib in monotherapy or in combination with carboplatin-paclitaxel and bevacizumab (CP + BEV) in Japanese patients with advanced solid tumors or non-squamous non-small cell lung cancer. A standard 3 + 3 dose escalation design was applied. In stage 1, 140, 260, or 340 mg/day of pictilisib was administered once daily to 12 patients with advanced solid tumors...
August 27, 2016: Investigational New Drugs
https://www.readbyqxmd.com/read/27558764/atypical-pityriasis-rosea-clinical-evaluation-of-27-patients
#14
Fadime Kilinc, Ayse Akbas, Sertac Sener, Akın Aktaş
BACKGROUND: Pityriasis rosea (PR) is a common, acute, self-limiting inflammatory skin disease. It can easily be recognized with its typical clinical presentation. However, unusual clinic presentations can cause difficulty in diagnosis. Up to now, not many atypical forms are reported. OBJECTIVE: To determine the clinical characteristics of patients with atypical pityriasis rosea. METHODS: A total of 27 cases, diagnosed as atypical PR by clinical and/or histopathological examination and applied to the outpatient clinic of dermatology department between the years 2007 and 2015 were analyzed retrospectively...
September 26, 2016: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/27551239/drug-induced-exfoliative-dermatitis-state-of-the-art
#15
REVIEW
Mona-Rita Yacoub, Alvise Berti, Corrado Campochiaro, Enrico Tombetti, Giuseppe Alvise Ramirez, Andrea Nico, Elisabetta Di Leo, Paola Fantini, Maria Grazia Sabbadini, Eustachio Nettis, Giselda Colombo
Drug induced exfoliative dermatitis (ED) are a group of rare and severe drug hypersensitivity reactions (DHR) involving skin and usually occurring from days to several weeks after drug exposure. Erythema multiforme (EM), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are the main clinical presentations of drug induced ED. Overall, T cells are the central player of these immune-mediated drug reactions. Here we provide a systematic review on frequency, risk factors, pathogenesis, clinical features and management of patients with drug induced ED...
2016: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/27497618/serum-tarc-levels-are-strongly-correlated-with-blood-eosinophil-count-in-patients-with-drug-eruptions
#16
Takayoshi Komatsu-Fujii, Sakae Kaneko, Yuko Chinuki, Yohji Suyama, Masataka Ohta, Hiroyuki Niihara, Eishin Morita
BACKGROUND: This study aims to evaluate the relationship between serum thymus and activation-regulated chemokine (TARC) levels with various clinicopathological conditions in patients with drug eruptions. The value of TARC in diagnosing drug-induced hypersensitivity syndrome (DIHS) was also examined. METHODS: Study participants included 84 patients who presented with generalized eruptions suspected to be drug-related, including DIHS, Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN), maculopapular exanthema (MPE), erythema multiforme (EM), erythroderma, and toxicoderma...
August 4, 2016: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/27470645/exudative-erythema-multiforme-due-to-cyclobenzaprine
#17
E Gómez Torrijos, M García Arpa, C García Rodríguez, Y Mendez Díaz, J Borja Segade, P A Galindo Bonilla, J F Feo Brito, R García Rodríguez
No abstract text is available yet for this article.
2016: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/27457767/a-retrospective-study-of-drug-induced-cutaneous-adverse-reactions-cadr-in-patients-attending-tertiary-care-hospital
#18
Khyati Doshi, Radha Yegnanarayan, Neeta Gokhale
OBJECTIVES: Find possible causative agents causing cutaneous adverse reactions; clinical patterns, causality and severity of Drug induced cutaneous adverse reactions (CADR) and treatment outcome. METHODS: Retrospective study was undertaken including cases of CADR. Causality, preventability and severity of Drug Induced cutaneous reactions were judged with the use of Naranjo's algorithm, WHO causality scale, modified Schumock and Thorton scale, and Hartwig's scale respectively...
July 24, 2016: Current Drug Safety
https://www.readbyqxmd.com/read/27455869/-terbinafine-drug-induced-lupus-erythematodes-and-triggering-of-psoriatic-skin-lesions
#19
REVIEW
P Mayser
Based on the technical information that oral terbinafine must be used with caution in patients with pre-existing psoriasis or lupus erythematosus, the literature was summarized. Terbinafine belongs to the drugs able to induce subcutaneous lupus erythematosus (SCLE)-with a relatively high risk. The clinical picture of terbinafine-induced SCLE may be highly variable and can also include erythema exsudativum multiforme-like or bullous lesions. Thus, differentiation of terbinafine-induced Stevens-Johnson syndrome or toxic epidermal necrolysis may be difficult...
September 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/27445155/atypical-hand-foot-and-mouth-disease-in-adults-associated-with-coxsackievirus-a6-a-clinico-pathologic-study
#20
Alvaro C Laga, Suzanne M Shroba, John Hanna
BACKGROUND: Hand, Foot, and Mouth Disease (HFMD) is a contagious illness most commonly occurring in children 5 years old or younger. The most common cause of HFMD in the United States is Coxsackievirus A16. HFMD is uncommon in adults, and may show other atypical features including a broader spectrum of cutaneous involvement and a greater degree of severity. METHODS: We evaluated the clinical, histopathologic, and molecular features of three cases of atypical HFMD occurring in adults...
July 22, 2016: Journal of Cutaneous Pathology
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