Benjamin Klocke, Aikaterini Britzolaki, Joseph Saurine, Hayden Ott, Kylie Krone, Kiara Bahamonde, Connor Thelen, Christos Tzimas, Despina Sanoudou, Evangelia G Kranias, Pothitos M Pitychoutis
The thalamic reticular nucleus (TRN) is a critical brain region that greatly influences vital neurobehavioral processes, including executive functioning and the generation of sleep rhythms. Recently, TRN dysfunction was suggested to underlie hyperactivity, attention deficits, and sleep disturbances observed across various devastating neurodevelopmental disorders, including autism, schizophrenia and attention-deficit/hyperactivity disorder (ADHD). Notably, a highly specialized sarco- endoplasmic reticulum calcium (Ca 2+ ) ATPase 2 (SERCA2)-dependent Ca 2+ signaling network operates in the dendrites of TRN neurons to regulate their high-frequency bursting activity...
November 23, 2023: bioRxiv