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JOURNAL ARTICLE
Catherine Riou, Jinal N Bhiman, Yashica Ganga, Shobna Sawry, Frances Ayres, Richard Baguma, Sashkia R Balla, Ntombi Benede, Mallory Bernstein, Asiphe S Besethi, Sandile Cele, Carol Crowther, Mrinmayee Dhar, Sohair Geyer, Katherine Gill, Alba Grifoni, Tandile Hermanus, Haajira Kaldine, Roanne S Keeton, Prudence Kgagudi, Khadija Khan, Erica Lazarus, Jean Le Roux, Gila Lustig, Mashudu Madzivhandila, Siyabulela F J Magugu, Zanele Makhado, Nelia P Manamela, Qiniso Mkhize, Paballo Mosala, Thopisang P Motlou, Hygon Mutavhatsindi, Nonkululeko B Mzindle, Anusha Nana, Rofhiwa Nesamari, Amkele Ngomti, Anathi A Nkayi, Thandeka P Nkosi, Millicent A Omondi, Ravindre Panchia, Faeezah Patel, Alessandro Sette, Upasna Singh, Strauss van Graan, Elizabeth M Venter, Avril Walters, Thandeka Moyo-Gwete, Simone I Richardson, Nigel Garrett, Helen Rees, Linda-Gail Bekker, Glenda Gray, Wendy A Burgers, Alex Sigal, Penny L Moore, Lee Fairlie
We report the safety and immunogenicity of fractional and full dose Ad26.COV2.S and BNT162b2 in an open label phase 2 trial of participants previously vaccinated with a single dose of Ad26.COV2.S, with 91.4% showing evidence of previous SARS-CoV-2 infection. A total of 286 adults (with or without HIV) were enrolled >4 months after an Ad26.COV2.S prime and randomized 1:1:1:1 to receive either a full or half-dose booster of Ad26.COV2.S or BNT162b2 vaccine. B cell responses (binding, neutralization and antibody dependent cellular cytotoxicity-ADCC), and spike-specific T-cell responses were evaluated at baseline, 2, 12 and 24 weeks post-boost...
2024: PLOS Glob Public Health
#2
JOURNAL ARTICLE
Julia Chisholm, Henry Mandeville, Madeleine Adams, Veronique Minard-Collin, Timothy Rogers, Anna Kelsey, Janet Shipley, Rick R van Rijn, Isabelle de Vries, Roelof van Ewijk, Bart de Keizer, Susanne A Gatz, Michela Casanova, Lisa Lyngsie Hjalgrim, Charlotte Firth, Keith Wheatley, Pamela Kearns, Wenyu Liu, Amanda Kirkham, Helen Rees, Gianni Bisogno, Ajla Wasti, Sara Wakeling, Delphine Heenen, Deborah A Tweddle, Johannes H M Merks, Meriel Jenney
The Frontline and Relapsed Rhabdomyosarcoma (FaR-RMS) clinical trial is an overarching, multinational study for children and adults with rhabdomyosarcoma (RMS). The trial, developed by the European Soft Tissue Sarcoma Study Group (EpSSG), incorporates multiple different research questions within a multistage design with a focus on (i) novel regimens for poor prognostic subgroups, (ii) optimal duration of maintenance chemotherapy, and (iii) optimal use of radiotherapy for local control and widespread metastatic disease...
February 29, 2024: Cancers
#3
Liang Chang, Nancy Y Jung, Adel Atari, Diego J Rodriguez, Devishi Kesar, Tian-Yu Song, Matthew G Rees, Melissa Ronan, Ruitong Li, Paloma Ruiz, Saireudee Chaturantabut, Takahiro Ito, Laurens M van Tienen, Yuen-Yi Tseng, Jennifer A Roth, William R Sellers
No abstract text is available yet for this article.
February 23, 2024: Nature Genetics
#4
JOURNAL ARTICLE
Cory J Holdom, Mark R Janse van Mantgem, Ji He, Stephanie L Howe, Pamela A McCombe, Dongsheng Fan, Leonard H van den Berg, Robert D Henderson, Ruben van Eijk, Frederik J Steyn, Shyuan T Ngo
BACKGROUND AND OBJECTIVES: Altered metabolism is observed in amyotrophic lateral sclerosis (ALS). However, without a standardized methodology to define metabolic changes, our understanding of factors contributing to and the clinical significance of altered metabolism in ALS is limited. METHODS: We aimed to determine how geographic variation in metabolic rates influences estimates and accuracy of predicted resting energy expenditure (REE) in patients with ALS and controls, while validating the effectiveness of cohort-specific approaches in predicting altered metabolic rate in ALS...
March 12, 2024: Neurology
#5
JOURNAL ARTICLE
Dorcas Tlhapi, Isaiah Ramaite, Chinedu Anokwuru, Teunis van Ree, Ntakadzeni Madala, Heinrich Hoppe
This study involves the investigation of various plant parts of Breonadia salicina (Vahl) Hepper and J.R.I. Wood across multiple consecutive seasons. It aims to delve into the phytochemistry of these different plant parts and establish connections between the findings and their biological activities. This comprehensive approach employs metabolomics techniques, with the ultimate goal of exploring the potential for drug development. Samples were collected in Fondwe, a village in Limpopo (South Africa), based on local reports of the efficacy of this plant used by traditional healers in the area...
January 30, 2024: Heliyon
#6
JOURNAL ARTICLE
Mark R Janse van Mantgem, Maaike L Soors D'Ancona, Myrte Meyjes, Leonard H Van Den Berg, Elles Steenhagen, Annemieke Kok, Ruben P A Van Eijk
AIM: To determine the validity of bioelectrical impedance analysis (BIA) in quantifying fat-free mass (FFM) compared to air-displacement plethysmography (ADP) in patients with a motor neurone disease (MND). METHODS: FFM of 140 patients diagnosed with MND was determined by ADP using the BodPod (i.e. the gold standard), and by BIA using the whole-body Bodystat. FFM values were translated to predicted resting energy expenditure (REE); the actual REE was measured using indirect calorimetry, resulting in a metabolic index...
January 24, 2024: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
#7
JOURNAL ARTICLE
Brigitte-Carole Keumatio Doungtsop, Eleonora Nardini, Hakan Kalay, Serge A Versteeg, Joyce Lübbers, Gaby van Barneveld, Eveline R J Li, Sandra J van Vliet, Ronald van Ree, Esther C de Jong, Yvette van Kooyk
BACKGROUND: House dust mite extract-based allergen immunotherapy (AIT) to treat house dust mite allergy is substantially effective but still presents some safety and efficacy concerns that warrant improvement. Several major allergen-based approaches to increase safety and efficacy of AIT have been proposed. One of them is the use of the group 2 allergen, Der p 2. OBJECTIVE: We sought to investigate the immunomodulatory effects of sialic acid-modified major allergen recombinant Der p 2 (sia-rDer p 2) on PBMCs from healthy volunteers...
February 2024: J Allergy Clin Immunol Glob
#8
JOURNAL ARTICLE
Rajeshwer S Sankhala, Vincent Dussupt, Wei-Hung Chen, Hongjun Bai, Elizabeth J Martinez, Jaime L Jensen, Phyllis A Rees, Agnes Hajduczki, William C Chang, Misook Choe, Lianying Yan, Spencer L Sterling, Isabella Swafford, Caitlin Kuklis, Sandrine Soman, Jocelyn King, Courtney Corbitt, Michelle Zemil, Caroline E Peterson, Letzibeth Mendez-Rivera, Samantha M Townsley, Gina C Donofrio, Kerri G Lal, Ursula Tran, Ethan C Green, Clayton Smith, Natalia de Val, Eric D Laing, Christopher C Broder, Jeffrey R Currier, Gregory D Gromowski, Lindsay Wieczorek, Morgane Rolland, Dominic Paquin-Proulx, Dewald van Dyk, Zachary Britton, Saravanan Rajan, Yueh Ming Loo, Patrick M McTamney, Mark T Esser, Victoria R Polonis, Nelson L Michael, Shelly J Krebs, Kayvon Modjarrad, M Gordon Joyce
Given the continuous emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VoCs), immunotherapeutics that target conserved epitopes on the spike (S) glycoprotein have therapeutic advantages. Here, we report the crystal structure of the SARS-CoV-2 S receptor-binding domain (RBD) at 1.95 Å and describe flexibility and distinct conformations of the angiotensin-converting enzyme 2 (ACE2)-binding site. We identify a set of SARS-CoV-2-reactive monoclonal antibodies (mAbs) with broad RBD cross-reactivity including SARS-CoV-2 Omicron subvariants, SARS-CoV-1, and other sarbecoviruses and determine the crystal structures of mAb-RBD complexes with Ab246 and CR3022 mAbs targeting the class IV site, WRAIR-2134, which binds the recently designated class V epitope, and WRAIR-2123, the class I ACE2-binding site...
December 16, 2023: Structure
#9
Catherine Riou, Jinal N Bhiman, Yashica Ganga, Shobna Sawry, Frances Ayres, Richard Baguma, Sashkia R Balla, Ntombi Benede, Mallory Bernstein, Asiphe S Besethi, Sandile Cele, Carol Crowther, Mrinmayee Dhar, Sohair Geyer, Katherine Gill, Alba Grifoni, Tandile Hermanus, Haajira Kaldine, Roanne S Keeton, Prudence Kgagudi, Khadija Khan, Erica Lazarus, Jean Le Roux, Gila Lustig, Mashudu Madzivhandila, Siyabulela Fj Magugu, Zanele Makhado, Nelia P Manamela, Qiniso Mkhize, Paballo Mosala, Thopisang P Motlou, Hygon Mutavhatsindi, Nonkululeko B Mzindle, Anusha Nana, Rofhiwa Nesamari, Amkele Ngomti, Anathi A Nkayi, Thandeka P Nkosi, Millicent A Omondi, Ravindre Panchia, Faeezah Patel, Alessandro Sette, Upasna Singh, Strauss van Graan, Elizabeth M Venter, Avril Walters, Thandeka Moyo-Gwete, Simone I Richardson, Nigel Garrett, Helen Rees, Linda-Gail Bekker, Glenda Gray, Wendy A Burgers, Alex Sigal, Penny L Moore, Lee Fairlie
BACKGROUND: We report the safety and immunogenicity of fractional and full dose Ad26.COV2.S and BNT162b2 in an open label phase 2 trial of participants previously vaccinated with a single dose of Ad26.COV2.S, with 91.4% showing evidence of previous SARS-CoV-2 infection. METHODS: A total of 286 adults (with or without HIV) were enrolled >4 months after an Ad26.COV2.S prime and randomized 1:1:1:1 to receive either a full or half-dose booster of Ad26.COV2.S or BNT162b2 vaccine...
November 20, 2023: medRxiv
#10
JOURNAL ARTICLE
Melissa L Boby, Daren Fearon, Matteo Ferla, Mihajlo Filep, Lizbé Koekemoer, Matthew C Robinson, John D Chodera, Alpha A Lee, Nir London, Annette von Delft, Frank von Delft, Hagit Achdout, Anthony Aimon, Dominic S Alonzi, Robert Arbon, Jasmin C Aschenbrenner, Blake H Balcomb, Elad Bar-David, Haim Barr, Amir Ben-Shmuel, James Bennett, Vitaliy A Bilenko, Bruce Borden, Pascale Boulet, Gregory R Bowman, Lennart Brewitz, Juliane Brun, Sarma Bvnbs, Mark Calmiano, Anna Carbery, Daniel W Carney, Emma Cattermole, Edcon Chang, Eugene Chernyshenko, Austin Clyde, Joseph E Coffland, Galit Cohen, Jason C Cole, Alessandro Contini, Lisa Cox, Tristan Ian Croll, Milan Cvitkovic, Steven De Jonghe, Alex Dias, Kim Donckers, David L Dotson, Alice Douangamath, Shirly Duberstein, Tim Dudgeon, Louise E Dunnett, Peter Eastman, Noam Erez, Charles J Eyermann, Michael Fairhead, Gwen Fate, Oleg Fedorov, Rafaela S Fernandes, Lori Ferrins, Richard Foster, Holly Foster, Laurent Fraisse, Ronen Gabizon, Adolfo García-Sastre, Victor O Gawriljuk, Paul Gehrtz, Carina Gileadi, Charline Giroud, William G Glass, Robert C Glen, Itai Glinert, Andre S Godoy, Marian Gorichko, Tyler Gorrie-Stone, Ed J Griffen, Amna Haneef, Storm Hassell Hart, Jag Heer, Michael Henry, Michelle Hill, Sam Horrell, Qiu Yu Judy Huang, Victor D Huliak, Matthew F D Hurley, Tomer Israely, Andrew Jajack, Jitske Jansen, Eric Jnoff, Dirk Jochmans, Tobias John, Benjamin Kaminow, Lulu Kang, Anastassia L Kantsadi, Peter W Kenny, J L Kiappes, Serhii O Kinakh, Boris Kovar, Tobias Krojer, Van Ngoc Thuy La, Sophie Laghnimi-Hahn, Bruce A Lefker, Haim Levy, Ryan M Lithgo, Ivan G Logvinenko, Petra Lukacik, Hannah Bruce Macdonald, Elizabeth M MacLean, Laetitia L Makower, Tika R Malla, Peter G Marples, Tatiana Matviiuk, Willam McCorkindale, Briana L McGovern, Sharon Melamed, Kostiantyn P Melnykov, Oleg Michurin, Pascal Miesen, Halina Mikolajek, Bruce F Milne, David Minh, Aaron Morris, Garrett M Morris, Melody Jane Morwitzer, Demetri Moustakas, Charles E Mowbray, Aline M Nakamura, Jose Brandao Neto, Johan Neyts, Luong Nguyen, Gabriela D Noske, Vladas Oleinikovas, Glaucius Oliva, Gijs J Overheul, C David Owen, Ruby Pai, Jin Pan, Nir Paran, Alexander Matthew Payne, Benjamin Perry, Maneesh Pingle, Jakir Pinjari, Boaz Politi, Ailsa Powell, Vladimír Pšenák, Iván Pulido, Reut Puni, Victor L Rangel, Rambabu N Reddi, Paul Rees, St Patrick Reid, Lauren Reid, Efrat Resnick, Emily Grace Ripka, Ralph P Robinson, Jaime Rodriguez-Guerra, Romel Rosales, Dominic A Rufa, Kadi Saar, Kumar Singh Saikatendu, Eidarus Salah, David Schaller, Jenke Scheen, Celia A Schiffer, Christopher J Schofield, Mikhail Shafeev, Aarif Shaikh, Ala M Shaqra, Jiye Shi, Khriesto Shurrush, Sukrit Singh, Assa Sittner, Peter Sjö, Rachael Skyner, Adam Smalley, Bart Smeets, Mihaela D Smilova, Leonardo J Solmesky, John Spencer, Claire Strain-Damerell, Vishwanath Swamy, Hadas Tamir, Jenny C Taylor, Rachael E Tennant, Warren Thompson, Andrew Thompson, Susana Tomásio, Charles W E Tomlinson, Igor S Tsurupa, Anthony Tumber, Ioannis Vakonakis, Ronald P van Rij, Laura Vangeel, Finny S Varghese, Mariana Vaschetto, Einat B Vitner, Vincent Voelz, Andrea Volkamer, Martin A Walsh, Walter Ward, Charlie Weatherall, Shay Weiss, Kris M White, Conor Francis Wild, Karolina D Witt, Matthew Wittmann, Nathan Wright, Yfat Yahalom-Ronen, Nese Kurt Yilmaz, Daniel Zaidmann, Ivy Zhang, Hadeer Zidane, Nicole Zitzmann, Sarah N Zvornicanin
We report the results of the COVID Moonshot, a fully open-science, crowdsourced, and structure-enabled drug discovery campaign targeting the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease. We discovered a noncovalent, nonpeptidic inhibitor scaffold with lead-like properties that is differentiated from current main protease inhibitors. Our approach leveraged crowdsourcing, machine learning, exascale molecular simulations, and high-throughput structural biology and chemistry. We generated a detailed map of the structural plasticity of the SARS-CoV-2 main protease, extensive structure-activity relationships for multiple chemotypes, and a wealth of biochemical activity data...
November 10, 2023: Science
#11
JOURNAL ARTICLE
Charles B van Rees, Darixa D Hernández-Abrams, Matthew Shudtz, Roderick Lammers, James Byers, Brian P Bledsoe, Matthew V Bilskie, Jon Calabria, Matthew Chambers, Emily Dolatowski, Susana Ferreira, Laura Naslund, Donald R Nelson, Nathan Nibbelink, Burton Suedel, Amanda Tritinger, C Brock Woodson, S Kyle McKay, Seth J Wenger
Civil infrastructure will be essential to face the interlinked existential threats of climate change and rising resource demands while ensuring a livable Anthropocene for all. However, conventional infrastructure planning largely neglects the contributions and maintenance of Earth's ecological life support systems, which provide irreplaceable services supporting human well-being. The stability and performance of these services depend on biodiversity, but conventional infrastructure practices, narrowly focused on controlling natural capital, have inadvertently degraded biodiversity while perpetuating social inequities...
November 14, 2023: Proceedings of the National Academy of Sciences of the United States of America
#12
JOURNAL ARTICLE
Bryan R E Smith, Kristina Reid Black, Max Bermingham, Sayeh Agah, Jill Glesner, Serge A Versteeg, Ronald van Ree, Glorismer Pena-Amelunxen, Lorenz Aglas, Scott A Smith, Anna Pomés, Martin D Chapman
INTRODUCTION: Allergic reactions are mediated by human IgE antibodies that bind to and cross-link allergen molecules. The sites on allergens that are recognized by IgE antibodies have been difficult to investigate because of the paucity of IgE antibodies in a human serum. Here, we report the production of unique human IgE monoclonal antibodies to major inhaled allergens and food allergens that can be produced at scale in perpetuity. MATERIALS AND METHODS: The IgE antibodies were derived from peripheral blood mononuclear cells of symptomatic allergic patients, mostly children aged 3-18 years, using hybridoma fusion technology...
2023: Front Allergy
#13
Glorismer Pena-Castellanos, Bryan R E Smith, Anna Pomés, Scott A Smith, Maria A Stigler, Hannah L Widauer, Serge A Versteeg, Ronald van Ree, Martin D Chapman, Lorenz Aglas
[This corrects the article DOI: 10.3389/fimmu.2023.1155613.].
2023: Frontiers in Immunology
#14
MULTICENTER STUDY
Mariska A M Schröder, Mihaela Neacşu, Bas P H Adriaansen, Fred C G J Sweep, S Faisal Ahmed, Salma R Ali, Tânia A S S Bachega, Federico Baronio, Niels Holtum Birkebæk, Christiaan de Bruin, Walter Bonfig, Jillian Bryce, Maria Clemente, Martine Cools, Heba Elsedfy, Evgenia Globa, Tulay Guran, Ayla Güven, Nermine Hussein Amr, Dominika Janus, Nina Lenherr Taube, Renata Markosyan, Mirela Miranda, Şükran Poyrazoğlu, Aled Rees, Mariacarolina Salerno, Marianna Rita Stancampiano, Ana Vieites, Liat de Vries, Zehra Yavas Abali, Paul N Span, Hedi L Claahsen-van der Grinten
IMPORTANCE: Testicular adrenal rest tumors (TARTs), often found in male patients with congenital adrenal hyperplasia (CAH), are benign lesions causing testicular damage and infertility. We hypothesize that chronically elevated adrenocorticotropic hormone exposure during early life may promote TART development. OBJECTIVE: This study aimed to examine the association between commencing adequate glucocorticoid treatment early after birth and TART development. DESIGN AND PARTICIPANTS: This retrospective multicenter (n = 22) open cohort study collected longitudinal clinical and biochemical data of the first 4 years of life using the I-CAH registry and included 188 male patients (median age 13 years; interquartile range: 10-17) with 21-hydroxylase deficiency (n = 181) or 11-hydroxylase deficiency (n = 7)...
October 17, 2023: European Journal of Endocrinology
#15
JOURNAL ARTICLE
Alexandra F Santos, Carmen Riggioni, Ioana Agache, Cezmi A Akdis, Mubeccel Akdis, Alberto Alvarez-Perea, Montserrat Alvaro-Lozano, Barbara Ballmer-Weber, Simona Barni, Kirsten Beyer, Carsten Bindslev-Jensen, Helen A Brough, Betul Buyuktiryaki, Derek Chu, Stefano Del Giacco, Audrey Dunn-Galvin, Bernadette Eberlein, Motohiro Ebisawa, Philippe Eigenmann, Thomas Eiwegger, Mary Feeney, Montserrat Fernandez-Rivas, Helen R Fisher, David M Fleischer, Mattia Giovannini, Claudia Gray, Karin Hoffmann-Sommergruber, Susanne Halken, Jonathan O'B Hourihane, Christina J Jones, Marek Jutel, Edward Knol, George N Konstantinou, Gideon Lack, Susanne Lau, Andreina Marques Mejias, Mary Jane Marchisotto, Rosan Meyer, Charlotte G Mortz, Beatriz Moya, Antonella Muraro, Caroline Nilsson, Lucila Camargo Lopes de Oliveira, Liam O'Mahony, Nikolaos G Papadopoulos, Kirsten Perrett, Rachel L Peters, Marcia Podesta, Lars K Poulsen, Graham Roberts, Hugh A Sampson, Jürgen Schwarze, Peter Smith, Elizabeth Huiwen Tham, Eva Untersmayr, Ronald Van Ree, Carina Venter, Brian P Vickery, Berber Vlieg-Boerstra, Thomas Werfel, Margitta Worm, George Du Toit, Isabel Skypala
This European Academy of Allergy and Clinical Immunology guideline provides recommendations for diagnosing IgE-mediated food allergy and was developed using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. Food allergy diagnosis starts with an allergy-focused clinical history followed by tests to determine IgE sensitization, such as serum allergen-specific IgE (sIgE) and skin prick test (SPT), and the basophil activation test (BAT), if available. Evidence for IgE sensitization should be sought for any suspected foods...
December 2023: Allergy
#16
JOURNAL ARTICLE
Martijn H van der Ree, Phillip S Cuculich, Marcel van Herk, Geoffrey D Hugo, Jippe C Balt, Matthew Bates, Gordon Ho, Etienne Pruvot, Claudia Herrera-Siklody, Wiert F Hoeksema, Justin Lee, Michael S Lloyd, Michiel J B Kemme, Frederic Sacher, Romain Tixier, Joost J C Verhoeff, Brian V Balgobind, Clifford G Robinson, Coen R N Rasch, Pieter G Postema
BACKGROUND: Stereotactic arrhythmia radioablation (STAR) is a potential new therapy for patients with refractory ventricular tachycardia (VT). The arrhythmogenic substrate (target) is synthesized from clinical and electro-anatomical information. This study was designed to evaluate the baseline interobserver variability in target delineation for STAR. METHODS: Delineation software designed for research purposes was used. The study was split into three phases. Firstly, electrophysiologists delineated a well-defined structure in three patients (spinal canal)...
2023: Frontiers in Cardiovascular Medicine
#17
JOURNAL ARTICLE
Liang Chang, Nancy Y Jung, Adel Atari, Diego J Rodriguez, Devishi Kesar, Tian-Yu Song, Matthew G Rees, Melissa Ronan, Ruitong Li, Paloma Ruiz, Saireudee Chaturantabut, Takahiro Ito, Laurens M van Tienen, Yuen-Yi Tseng, Jennifer A Roth, William R Sellers
The paradigm of cancer-targeted therapies has focused largely on inhibition of critical pathways in cancer. Conversely, conditional activation of signaling pathways as a new source of selective cancer vulnerabilities has not been deeply characterized. In this study, we sought to systematically identify context-specific gene-activation-induced lethalities in cancer. To this end, we developed a method for gain-of-function genetic perturbations simultaneously across ~500 barcoded cancer cell lines. Using this approach, we queried the pan-cancer vulnerability landscape upon activating ten key pathway nodes, revealing selective activation dependencies of MAPK and PI3K pathways associated with specific biomarkers...
October 2023: Nature Genetics
#18
REVIEW
Michael W Mullowney, Katherine R Duncan, Somayah S Elsayed, Neha Garg, Justin J J van der Hooft, Nathaniel I Martin, David Meijer, Barbara R Terlouw, Friederike Biermann, Kai Blin, Janani Durairaj, Marina Gorostiola González, Eric J N Helfrich, Florian Huber, Stefan Leopold-Messer, Kohulan Rajan, Tristan de Rond, Jeffrey A van Santen, Maria Sorokina, Marcy J Balunas, Mehdi A Beniddir, Doris A van Bergeijk, Laura M Carroll, Chase M Clark, Djork-Arné Clevert, Chris A Dejong, Chao Du, Scarlet Ferrinho, Francesca Grisoni, Albert Hofstetter, Willem Jespers, Olga V Kalinina, Satria A Kautsar, Hyunwoo Kim, Tiago F Leao, Joleen Masschelein, Evan R Rees, Raphael Reher, Daniel Reker, Philippe Schwaller, Marwin Segler, Michael A Skinnider, Allison S Walker, Egon L Willighagen, Barbara Zdrazil, Nadine Ziemert, Rebecca J M Goss, Pierre Guyomard, Andrea Volkamer, William H Gerwick, Hyun Uk Kim, Rolf Müller, Gilles P van Wezel, Gerard J P van Westen, Anna K H Hirsch, Roger G Linington, Serina L Robinson, Marnix H Medema
Developments in computational omics technologies have provided new means to access the hidden diversity of natural products, unearthing new potential for drug discovery. In parallel, artificial intelligence approaches such as machine learning have led to exciting developments in the computational drug design field, facilitating biological activity prediction and de novo drug design for molecular targets of interest. Here, we describe current and future synergies between these developments to effectively identify drug candidates from the plethora of molecules produced by nature...
September 11, 2023: Nature Reviews. Drug Discovery
#19
JOURNAL ARTICLE
Hanneke P F X Moonen, Anoek J H Hermans, Anneloes E Bos, Ilana Snaterse, Eline Stikkelman, Florianne J L van Zanten, Sabien H van Exter, Marcel C G van de Poll, Arthur R H van Zanten
PURPOSE: The metabolic course during and after critical illness is unclear. We performed repeated indirect calorimetry (IC) measurements during ICU- and post-ICU hospitalization to determine resting energy expenditure (REE). METHODS: Prospective observational design. In ventilated ICU patients, IC measurements were performed every three days until hospital discharge. Measured REE as predicted by the Harris-Benedict equation (HBE-REE) and 25 kcal/adjusted body weight/day (25-REE) were compared...
December 2023: Journal of Critical Care
#20
JOURNAL ARTICLE
E J J Kallen, A Revers, M Fernández-Rivas, R Asero, B Ballmer-Weber, L Barreales, S Belohlavkova, F de Blay, M Clausen, R Dubakiene, M Ebisawa, C Fernández-Perez, P Fritsche, Y Fukutomi, D Gislason, K Hoffmann-Sommergruber, M Jedrzejczak-Czechowicz, A C Knulst, M L Kowalski, T Kralimarkova, J Lidholm, C Metzler, E N C Mills, N G Papadopoulos, T A Popov, A Purohit, I Reig, S L Seneviratne, A Sinaniotis, M Takei, S A Versteeg, A E Vassilopoulou, S Vieths, P M J Welsing, A H Zwinderman, T M Le, R Van Ree
BACKGROUND: Pru p 3 and Pru p 7 have been implicated as risk factors for severe peach allergy. This study aimed to establish sensitization patterns to five peach components across Europe and in Japan, to explore their relation to pollen and foods and to predict symptom severity. METHODS: In twelve European (EuroPrevall project) and one Japanese outpatient clinic, a standardized clinical evaluation was conducted in 1231 patients who reported symptoms to peach and/or were sensitized to peach...
September 2023: Allergy
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