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erythema nodosum

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https://www.readbyqxmd.com/read/28643285/skin-manifestations-of-inflammatory-bowel-disease
#1
REVIEW
Thomas Greuter, Alexander Navarini, Stephan R Vavricka
Inflammatory bowel disease (IBD) with its two main subtypes Crohn's disease and ulcerative colitis is not restricted to the gastrointestinal tract. Indeed, so-called extraintestinal manifestations (EIMs) are frequent and considerably affect morbidity and mortality. The prevalence of EIMs ranges from 6 to 47%. In up to one quarter of the patients, EIMs can present even before an IBD diagnosis is established. The pathophysiology of EIMs remains elusive, although data from clinical trials demonstrating anti-tumor necrosis factor (TNF) efficacy suggest a common pathogenic link between intestinal and extraintestinal disease activity...
June 23, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28638429/adalimumab-responsive-refractory-sarcoidosis-following-multiple-eyebrow-tattoos-a-case-report
#2
Alireza Mirzaei, Mohamad Mehdi Joharimoghadam, Mozhdeh Zabihiyeganeh
Sarcoidosis is a granulomatous disease that can involve multiple organs including the lungs, eyes, nerves, and skin. Cosmetic tattooing can be a predisposing factor for sarcoidosis, and its incidence is likely to increase along with its popularity. A 47-year-old woman with symptoms of fever and polyarthritis along with erythema nodosum lesions on the legs, swollen eyebrows, and a history of multiple eyebrow tattooing was referred to our center. Since the signs and symptoms were positive for Löfgren's syndrome triad including erythema nodosum, bilateral hilar lymphadenopathy, and polyarthritis, a diagnosis of acute sarcoidosis was made, and treatment was started accordingly...
2017: Tanaffos
https://www.readbyqxmd.com/read/28634591/examination-of-the-microbial-spectrum-in-the-etiology-of-erythema-nodosum-a-retrospective-descriptive-study
#3
Ozlem Ozbagcivan, Sevgi Akarsu, Ceylan Avci, Burcu Bahar Inci, Emel Fetil
Even though infections are the most common cause of erythema nodosum (EN), only certain microorganisms take the great interest such as streptococci in knowledge. Our aim was to examine the frequency and type of infections in EN, to determine the characteristics of patients with an infectious etiology, and to discuss the role of these microbes in EN pathology in the context of their interactions with humans. Charts of 81 patients with EN who were seen between 2003 and 2017 were retrospectively reviewed. Identified etiological factors were classified into three groups: infectious, noninfectious, and idiopathic...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28631704/-beh%C3%A3-et-s-disease-intracardiac-thrombosis-a-description-of-two-cases-and-a-review-of-literature
#4
Z S Alekberova, P S Ovcharov, T A Lisitsyna, A V Volkov, T V Popkova
Behçet's disease (BD) is systemic vasculitis of unknown etiology, which is more common in the countries located along the Great Silk Road. The disease is diagnosed if a patient has 4 key diagnostic signs: aphthous stomatitis, genital sores, and eye and skin lesions. Vascular diseases referred to as minor criteria for BD are characterized by the formation of aneurysms and thrombosis, predominantly in the venous bed. In venous disorders, a blood clot can form in any vessel, including caval, cerebral, pulmonary, and other veins...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28621118/concurrent-sweet-s-syndrome-and-erythema-nodosum-in-a-patient-with-bilio-pancreatic-diversion
#5
Luca M Muscardin, Giovanni Paolino, Carlo Cota, Dario Didona, Chiara Panetta, Pietro Donati
No abstract text is available yet for this article.
August 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28598451/role-of-s-100-immunostain-as-an-auxiliary-diagnostic-aid-in-leprosy
#6
R Dhakhwa, S Acharya, S Pradhan, S B Shrestha, T Itoh
INTRODUCTION: Histopathologic diagnosis of leprosy is difficult when Bacillary Index (BI) is zero and neural involvement are not easily identifiable on routine Hematoxylin and Eosin stain. This study was undertaken to study the role of S-100 immunostaining in demonstrating different patterns of nerve involvement in various types of leprosy. METHODS: Thirty one skin biopsies with clinico-histopathologic diagnoses of leprosy over a period of two years were included in the study...
January 2017: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/28584854/lysinibacillus-massiliensis-panniculitis-masquerading-as-erythema-nodosum-a-case-report
#7
Jay J Jin, Phillip J Keith, Nathan W Cummins, Sunanda V Kane, Bobbi S Pritt, Joyce L Sanchez
Lysinibacillus massiliensis, formerly Bacillus massiliensis, is an environmental Gram-positive bacillus that is generally non-pathogenic. Rare case reports in immunosuppressed patients have described sepsis with this organism. In this study, we report a case of L massiliensis as a cause of infectious panniculitis mimicking erythema nodosum after infusion of autologous adipose-derived stem cells in an immunosuppressed patient with refractory Crohn's disease. This case highlights the importance of care providers to consider exposures and host factors when interpreting culture results with otherwise benign organisms...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28581039/efficacy-of-cytapheresis-for-remission-induction-and-dermatological-manifestations-of-ulcerative-colitis
#8
Osamu Nomura, Taro Osada, Tomoyoshi Shibuya, Dai Ishikawa, Keiichi Haga, Tomohiro Kodani, Naoto Sakamoto, Tatsuo Ogihara, Ken Yamaji, Sumio Watanabe
BACKGROUND: In ulcerative colitis (UC) patients, cytapheresis depletes elevated and activated leucocytes, which are known to release inflammatory cytokines including tumor necrosis factor (TNF)-α. Further, there are UC patients who develop erythema nodosum (EN) or pyoderma gangrenosum (PG) as extra-intestinal manifestations of UC. METHODS: Between 2008 and 2015, 181 consecutive patients with active UC received cytapheresis with either a granulocyte and monocyte apheresis (GMA) column or with a leucocyte removal filter (LCAP) as remission induction therapy...
June 5, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28577055/-evidence-of-compression-therapy
#9
REVIEW
W Konschake, E Valesky, H Stege, M Jünger
BACKGROUND: Medical compression therapy is widely used to treat phlebologic diseases. Compression bandages as well as compression stockings are used. Compression has been identified to be an effective conservative therapy for the healing of venous ulcers and other indications. Thus, the evidence for the use of medical compression therapy and for which indications is presented. MATERIALS AND METHODS: Review and systematic presentation of the evidence-based use of compression...
June 2, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28571559/a-mini-review-on-thalidomide-chemistry-mechanisms-of-action-therapeutic-potential-and-anti-angiogenic-properties-in-multiple-myeloma
#10
Annalisa Mercurio, Giulia Adriani, Alessia Catalano, Alessia Carocci, Luigia Rao, Giovanni Lentini, Maria Maddalena Cavalluzzi, Carlo Franchini, Angelo Vacca, Filomena Corbo
Thalidomide is a drug with interesting therapeutic properties but also with severe side effects, which require a careful and monitored use. Potential immunomodulatory, anti-inflammatory, anti-angiogenic and sedative properties make thalidomide a good candidate for the treatment of several diseases such as multiple myeloma. Through an increase in the degradation of TNFα-mRNA, thalidomide reduces the production of TNFα by monocytes and macrophages stimulated by lipopolysaccharide or by T lymphocytes induced by mitogenic stimuli...
May 31, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28558848/-erythema-nodosum-as-a-reaction-pattern-a-broad-spectrum-of-underlying-causes
#11
A L Bosma, M M Stok, H van der Valk, M C G van Praag
Erythema nodosum is a skin disorder that is characterised by the presence of painful erythematous nodules and plaques, mainly located on the shins. This disorder is associated with comorbidities and can be considered as an aspecific reaction pattern to a broad range of causes. However, an idiopathic variant also exists, which occurs in 22-72% of cases. Erythema nodosum is pre-eminently a skin disease which, due to its multifactorial pathogenesis, occurs in a wider field than dermatology alone. Therefore, knowledge of this disorder is important for all practicing physicians...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28547523/cutaneous-manifestations-of-medium-and-large-vessel-vasculitis
#12
REVIEW
Francois Chasset, Camille Francès
Dermatologic manifestations are observed in almost all systemic vasculitides, even in large-and medium-vessel vasculitides, although such vessels are not found in the skin. Cutaneous manifestations may be related to a direct skin localization of the systemic vasculitis or a non-specific process associated with the vasculitis. According to the 2012 International Chapel Hill consensus, the two major variants of large-vessel vasculitides are Takayasu arteritis and giant-cell arteritis. In Europe and North America, acute inflammatory nodules or erythema nodosum-like lesions are the most commonly observed skin lesions with Takayasu arteritis...
May 26, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28521705/thalidomide-induced-deep-venous-thrombosis-in-a-case-of-steroid-dependent-erythema-nodosum-leprosum-a-management-conundrum
#13
Upinder Kaur, Sankha Shubhra Chakrabarti, Indrajeet Singh Gambhir, Rohit Singh
Thalidomide, previously banned owing to the issues of teratogenicity is being used and tested for a variety of dermatological and non dermatological conditions. The drug has been approved for the management of ENL and Multiple myeloma. The drug is commonly known to produce adverse effects like peripheral neuropathy and constipation. Deep vein thrombosis (DVT) is one of the serious adverse effects seen with thalidomide use, especially in malignancies and is relatively uncommon in non cancer settings like ENL...
May 18, 2017: Current Drug Safety
https://www.readbyqxmd.com/read/28505186/in-situ-complement-activation-and-t-cell-immunity-in-leprosy-spectrum-an-immunohistological-study-on-leprosy-lesional-skin
#14
Nawal Bahia El Idrissi, Anand M Iyer, Valeria Ramaglia, Patricia S Rosa, Cleverson T Soares, Frank Baas, Pranab K Das
Mycobacterium leprae (M. leprae) infection causes nerve damage and the condition worsens often during and long after treatment. Clearance of bacterial antigens including lipoarabinomannan (LAM) during and after treatment in leprosy patients is slow. We previously demonstrated that M. leprae LAM damages peripheral nerves by in situ generation of the membrane attack complex (MAC). Investigating the role of complement activation in skin lesions of leprosy patients might provide insight into the dynamics of in situ immune reactivity and the destructive pathology of M...
2017: PloS One
https://www.readbyqxmd.com/read/28488045/-musculoskeletal-manifestations-of-sarcoidosis
#15
REVIEW
P Korsten, G Chehab
Musculoskeletal manifestations in the context of sarcoidosis are frequently observed. The rheumatologist regularly encounters this disease in clinical practice. In the present review, we aim to give a current overview of the manifestations and treatments relevant to the practicing rheumatologist. The most frequently encountered manifestation is Lofgren's syndrome, which is characterized by bilateral ankle periarthritis, bilateral hilar lymphadenopathy, and erythema nodosum and has an excellent prognosis. Chronic arthropathy most commonly manifests as oligoarthritis, which sometimes hampers its differentiation from spondylarthropathies, especially when sacroiliitis, enthesitis or dactylitis are simultaneously present...
June 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28440875/skin-manifestations-among-gata2-deficient-patients
#16
A Polat, M Dinulescu, S Fraitag, S Nimubona, F Toutain, S Jouneau, E Poullot, C Droitcourt, A Dupuy
GATA2 mutations have been identified in various diseases, such as monoMAC syndrome, Emberger syndrome, familial myelodysplastic syndrome, acute myeloid leukemia, and dendritic cell, monocyte, B and NK cell deficiency. These syndromes present a wide range of clinical features, dominated by severe infections and haematological disorders such as myelodysplastic syndrome. Up to 70% of GATA2-mutated patients have dermatological features, mainly genital or extra-genital warts, panniculitis or erythema nodosum, and lymphedema...
April 25, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28429672/the-molecular-mechanisms-of-thalidomide-teratogenicity-and-implications-for-modern-medicine
#17
J Knobloch, D Jungck, A Koch
Thalidomide is a teratogen that affects many organs but primarily induces limb truncations like phocomelia. Rodents are thalidomide resistant. In the 1950s, this has led to misinterpretations of animal tests and to the fatal assumption that the drug was safe for pregnant women to use against morning sickness. The result was one of the biggest scandals in medical history: 10.000 and more infants with birth defects in Europe. Nonetheless, thalidomide still has its place in modern medicine as it has strong therapeutic potential: it has been approved by the FDA for multiple myeloma and erythema nodosum leprosum, and its anti-inflammatory, immunomodulatory and anti-angiogenic activities are considered in many other refractory diseases...
March 31, 2017: Current Molecular Medicine
https://www.readbyqxmd.com/read/28406760/adherence-to-guidelines-for-the-treatment-of-beh%C3%A3-et-s-syndrome-in-new-york-and-amsterdam
#18
Floor G Kerstens, Franktien Turkstra, Selma Atalay, Richard M van Vugt, Christopher J Swearingen, Yusuf Yazici
OBJECTIVES: To assess adherence to published guidelines for the treatment of Behçet's syndrome (BS) in two geographic areas. METHODS: We extracted guideline statements from the 2008 EULAR recommendations. Adherence to these statements was evaluated retrospectively in both New York (USA) and Amsterdam (The Netherlands), by reviewing records from patients fulfilling the ISG criteria. We analysed data per statement and event, and divided data according to the year in which an event occurred...
April 13, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28406402/beh%C3%A3-et-disease-in-western-algeria
#19
M E A Ghembaza, N Bouabdallah, A Lounici
The aim of the current study was to describe the epidemiological and clinical features of Behçet disease in western Algeria. This observational retrospective study examined records for patients with Behçet disease seen in our department from 1990 to 2015. Of the 61 patients included in the study, 80.3% were men, for a sex ratio of 4.08. The mean age at onset was 27.2±7 years, and the mean interval between the onset of symptoms and diagnosis was 4.8±6.3 years. Dermatologic manifestations were the most common finding...
February 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28387077/-erythema-nodosum-a-panniculitis-of-diverse-origins
#20
REVIEW
G E Piérard, C Piérard-Franchimont
Erythema nodosum is an acute nodular panniculitis, mainly affecting young women. Diverse etiologies are evoked, but the most frequent are sarcoidosis (Löfgren syndrome), streptococcal infections, yersiniosis and inflammatory enteropathies. Antalgic drugs and rest are usually adequate in this condition, which is spontaneously of favourable evolution. Treatment of the cause is open to discussion, considering their lack of effect on the evolution of erythema nodosum.
January 2017: Revue Médicale de Liège
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