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erythema nodosum

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https://www.readbyqxmd.com/read/27859670/leprosy-reactions-in-post-elimination-stage-the-bangladesh-experience
#1
Mohammad Rafiqul Mowla, Shamim Ara, Afm Mizanur Rahman, Sanai Prue Tripura, Sujat Paul
BACKGROUND: Leprosy reactions are immunologically mediated conditions and a major cause of disability before, during and after multidrug therapy. Little data has been published on the epidemiology of leprosy reactions in Bangladesh. OBJECTIVES: To describe the pattern and prevalence of leprosy reactions in the post elimination stage. METHODS: A descriptive retrospective cross-sectional study was carried out in Chittagong Medical College Hospital using the registered records of patients the periods between 2004 and 2013...
November 15, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27830291/-cutaneous-involvement-in-chronic-inflammatory-bowel-disease-crohn-s-disease-and-ulcerative-colitis
#2
REVIEW
L Richter, K Rappersberger
BACKGROUND: Over recent decades, both the incidence and prevalence of chronic inflammatory bowel disease have continued to rise in industrialized countries; the disease is frequently associated with extracutaneous involvement and comorbidity. OBJECTIVES: The purpose of this work was to investigate the frequency and specificity of mucocutaneous manifestations in Crohn's disease (CD) and ulcerative colitis (UC). MATERIALS AND METHODS: An extensive search in peer-reviewed journals via PubMed was performed; presented is a summary and analysis of various studies and data, including data of patients treated at our department...
December 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/27814421/metastatic-crohn-disease-clinically-reminiscent-of-erythema-nodosum-on-the-right-leg
#3
Hyun C Park, Hyun W Kim, Chan G Park, Joo Y Ko
Cutaneous manifestations are well-recognized complications of Crohn disease (CD) that can be divided into disease-specific and reactive conditions. One of the most common reactive conditions is erythema nodosum (EN), which presents as subcutaneous tender nodules most often on the legs. On the other hand, metastatic Crohn disease (MCD) is a rare cutaneous manifestation of CD defined as the presence of noncaseating granulomas that are not contiguous with the gastrointestinal (GI) tract. The clinical presentation of MCD is variable; however, lesions often are located on the legs and genital region...
September 2016: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/27808062/inflammatory-leg-nodules-a-clinical-and-investigational-study
#4
Sujay Khandpur, K Maharaja
BACKGROUND: Inflammatory leg nodules are a diagnostically challenging group of dermatoses with limited tools for diagnosis. Considerable overlapping patterns exist despite their distinct clinical and histological features. We attempted to understand if undertaking investigations and studying the clinical course and treatment response can help in differentiating these dermatoses. METHODS: Forty-three patients presenting with inflammatory leg nodules underwent a series of investigations apart from histopathology...
May 2016: National Medical Journal of India
https://www.readbyqxmd.com/read/27784508/erythema-nodosum-and-the-risk-of-tuberculosis-in-a-high-incidence-setting
#5
REVIEW
Karen Bjorn-Mortensen, Karin Ladefoged, Jacob Simonsen, Sascha W Michelsen, Hans Christian F Sørensen, Anders Koch, Troels Lillebaek, Aase Bengaard Andersen, Bolette Soborg
OBJECTIVE: This study estimates the erythema nodosum (EN) incidence in a tuberculosis (TB) endemic setting and evaluates the likelihood of a subsequent TB diagnosis among individuals with Mycobacterium tuberculosis infection (MTI) with or without EN. DESIGN: We estimated EN incidence rates (IRs) in East Greenland in 2010-2011 and conducted a cohort study following all individuals who tested positive for MTI from 1 January 2010 until 31 December 2012. A personal identifier allowed individual follow-up in the mandatory TB register...
2016: International Journal of Circumpolar Health
https://www.readbyqxmd.com/read/27775948/erythema-nodosum-like-panniculitis-as-a-false-positive-18f-fdg-pet-ct-in-advanced-melanoma-treated-with-dabrafenib-and-trametinib
#6
Isabel Martínez-Rodríguez, Almudena García-Castaño, Remedios Quirce, Julio Jiménez-Bonilla, Ignacio Banzo
We present a 35-year-old woman with left axillary mass. Histopathological analysis revealed metastatic infiltration for BRAF-mutant melanoma. F-FDG PET/CT showed bilateral axillary lymphadenopathy as well as bone and subcutaneous metastases. Dabrafenib (a BRAF inhibitor) and trametinib (a MEK inhibitor) combined therapy was started with a complete metabolic response established by 2 consecutive PET/CT scans. A follow-up PET/CT showed FDG uptake in several subcutaneous nodules in both distal legs, suggesting metastases...
October 21, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27758984/clinical-features-of-sarcoidosis-in-oman-a-report-from-the-middle-east-region
#7
B Jayakrishnan, Nasser Al-Busaidi, Ahsan Al-Lawati, Jojy George, Omar A Al-Rawas, Yaqoub Al-Mahrouqi, Nabil Al-Lawati
BACKGROUND: Though clinical features of sarcoidosis follow a similar pattern, some heterogeneity is seen in different ethnic and racial groups. OBJECTIVES: To describe for the first time the clinical characteristics of sarcoidosis patients in the Sultanate of Oman. METHODS: The data on all cases of sarcoidosis followed up in the two tertiary hospitals in Oman were retrieved retrospectively. RESULTS: Of the 92 patients, for representing the ethnic data only Omani patients (n=83) were included...
October 7, 2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
https://www.readbyqxmd.com/read/27731528/characteristics-of-sarcoidosis-in-maori-and-pacific-islanders
#8
Margaret L Wilsher, Lisa M Young, Raewyn Hopkins, Megan Cornere
BACKGROUND AND OBJECTIVE: Ethnicity is strongly associated with variable clinical presentation in sarcoidosis but the association between ethnicity and clinical characteristics has not previously been described in patients of Polynesian ancestry, Maori and Pacific Islander (PI). The objective of this study was to describe the clinical characteristics of sarcoidosis in Maori and PI patients and determine if those were different to European patients. METHODS: A retrospective review of the medical records of 406 patients (69 Maori/PI) attending a specialist interstitial lung disease (ILD) clinic...
October 12, 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27730040/an-interesting-case-of-lucio-phenomenon-triggered-by-activation-of-hepatitis-c-infection
#9
Jacob Mareen, Jithendriya Madhukara
Lucio phenomenon (LP) or erythema necroticans is a rare type of reaction pattern found in untreated patients with diffuse non-nodular leprosy. It is important to distinguish this from vasculonecrotic erythema nodosum because thalidomide with high-dose steroids is the mainstay of treatment for the latter, whereas LP shows no response to thalidomide. We report a case of a 60-year-old man who presented with purpuric patches, hemorrhagic blisters, and ulcers over extremities of 15 days duration. On cutaneous examination, there were multiple stellate purpuric patches, hemorrhagic bullae, and deep necrotic ulcers, mainly over extremities...
September 2016: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/27728405/erythema-nodosum-leprosum-as-a-cause-of-pyrexia-of-unknown-origin
#10
N S Kochar, B Sehgal, B Kanish, K Kwatra, L Solomon
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27699251/cell-type-deconvolution-with-immune-pathways-identifies-gene-networks-of-host-defense-and-immunopathology-in-leprosy
#11
Megan S Inkeles, Rosane M B Teles, Delila Pouldar, Priscila R Andrade, Cressida A Madigan, David Lopez, Mike Ambrose, Mahdad Noursadeghi, Euzenir N Sarno, Thomas H Rea, Maria T Ochoa, M Luisa Iruela-Arispe, William R Swindell, Tom H M Ottenhoff, Annemieke Geluk, Barry R Bloom, Matteo Pellegrini, Robert L Modlin
Transcriptome profiles derived from the site of human disease have led to the identification of genes that contribute to pathogenesis, yet the complex mixture of cell types in these lesions has been an obstacle for defining specific mechanisms. Leprosy provides an outstanding model to study host defense and pathogenesis in a human infectious disease, given its clinical spectrum, which interrelates with the host immunologic and pathologic responses. Here, we investigated gene expression profiles derived from skin lesions for each clinical subtype of leprosy, analyzing gene coexpression modules by cell-type deconvolution...
September 22, 2016: JCI Insight
https://www.readbyqxmd.com/read/27687069/intravascular-large-b-cell-lymphoma-presenting-as-transient-erythema-nodosum-like-lesions-and-fever
#12
David J Tsoulis, Danny Ghazarian, Eugenia Poliotis, Scott Walsh
No abstract text is available yet for this article.
September 26, 2016: American Journal of Medicine
https://www.readbyqxmd.com/read/27608798/idiopathic-granulomatous-mastitis-with-erythema-nodosum-and-polyarthritis
#13
J Alungal, M C Abdulla, R Narayan
A 25 year-old woman presented with a painful mass in the left breast, polyarthritis and erythema nodosum. Fine needle aspiration cytology led to a diagnosis of granulomatous mastitis. Oral prednisolone rapidly improved the arthritis and the erythema nodosum. Granulomatous mastitis is a very rare, chronic inflammatory disease and only ten patients with granulomatous mastitis with erythema nodosum and polyarthitis have been described.
2016: Reumatismo
https://www.readbyqxmd.com/read/27599416/efficacy-and-adverse-events-of-azacitidine-in-the-treatment-of-hemodialysis-patients-with-high-risk-myelodysplastic-syndrome
#14
Tomoyasu Yoshihiro, Tsuyoshi Muta, Kenichi Aoki, Syo Shimamoto, Yasuhisa Tamura, Ryosuke Ogawa
We describe two hemodialysis patients with high-risk myelodysplastic syndrome (MDS) treated with azacitidine. A 65-year-old woman (case 1) received azacitidine at 75 mg/m(2) for 7 days, and a 52-year-old man (case 2) with liver cirrhosis received a 70% dose of azacitidine. Both cases developed grade 4 cytopenia, but they achieved transfusion independence after 3 and 2 courses, and the durations of remission were 10 and 11 months, respectively. Case 1 had the complication of febrile neutropenia (FN) twice during the 1(st) and 2(nd) courses, but continued to receive azacitidine treatment thereafter...
August 2016: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/27583087/amylo%C3%A3-dosis-sarcoidosis-and-systemic-lupus-erythematosus
#15
Amel Rezgui, Imene Ben Hassine, Monia Karmani, Fatma Ben Fredj, Chadia Laouani
The occurrence of renal and multiple organ Amyloïdosis is currently considered exceptional in the course of systemic lupus erythematosus. We report a case of a concomitant SLE and Amyloïdosis in a 57 year old female patient with hypothyroidism history, who presented with erythema nodosum, fever, arthralgia and sicca syndrome. Biological findings showed an inflammatory syndrome, renal failure, proteinuria (1g / 24h), positive auto antibodies and anti DNA. Lung radiology revealed medistinal lymphadenopathy, pleural nodules, ground glass infiltrates and pleuritis...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27562330/-pasteurella-multocida-cellulitis-after-cat-bite-and-subsequent-erythema-nodosum
#16
J Morera Montes, M J Lucena Martín, V Morera Navarro, M Gómez García
No abstract text is available yet for this article.
August 22, 2016: Semergen
https://www.readbyqxmd.com/read/27559497/quality-of-life-in-patients-with-erythema-nodosum-leprosum-in-kuala-lumpur-malaysia
#17
Felix B Yap, Sze T Kiung, Jeffrey B Yap
BACKGROUND: There is a paucity of data on quality of life issues in patients with leprosy suffering from erythema nodosum leprosum (ENL). Thus, we aim to study the effect of ENL on quality of life. MATERIALS AND METHODS: This cross-sectional study was conducted in Hansen's Clinic, Hospital Kuala Lumpur between January 2010 and December 2013 among patients with multibacillary leprosy using the Dermatology Life Quality Index (DLQI). RESULTS: A total of 153 patients participated with 31...
July 2016: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/27556927/expression-of-cd64-on-circulating-neutrophils-favoring-systemic-inflammatory-status-in-erythema-nodosum-leprosum
#18
Veronica Schmitz, Rhana Berto da Silva Prata, Mayara Garcia de Mattos Barbosa, Mayara Abud Mendes, Sheila Santos Brandão, Thaís Porto Amadeu, Luciana Silva Rodrigues, Helen Ferreira, Fabrício da Mota Ramalho Costa, Jessica Brandão Dos Santos, Fabiana Dos Santos Pacheco, Alice de Miranda Machado, José Augusto da Costa Nery, Mariana de Andrea Hacker, Anna Maria Sales, Roberta Olmo Pinheiro, Euzenir Nunes Sarno
Erythema Nodosum Leprosum (ENL) is an immune reaction in leprosy that aggravates the patient´s clinical condition. ENL presents systemic symptoms of an acute infectious syndrome with high leukocytosis and intense malaise clinically similar to sepsis. The treatment of ENL patients requires immunosuppression and thus needs to be early and efficient to prevent both disabilities and permanent nerve damage. Some patients experience multiple episodes of ENL and prolonged use of immunosuppressive drugs may lead to serious adverse effects...
August 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27538006/erythema-nodosum-like-septal-panniculitis-secondary-to-lenalidomide-therapy-in-a-patient-with-janus-kinase-2-positive-myelofibrosis
#19
Tatyana A Petukhova, Danielle M Tartar, Karen Mayo, Maxwell A Fung, Joseph Tuscano, Jared Jagdeo
Erythema nodosum (EN) is a panniculitis frequently encountered secondary to medical therapy. We present a case of a 66-year-old gentleman with JAK2-positive myelofibrosis who developed transient EN-like lesions on his trunk and upper and lower extremities approximately three weeks after starting lenalidomide therapy. The subcutaneous nodules improved with intralesional triamcinolone and topical clobetasol without discontinuation of lenalidomide.<br /><br /> <em>J Drugs Dermatol</em>...
August 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/27529720/azathioprine-hypersensitivity-presenting-as-neutrophilic-dermatosis-and-erythema-nodosum
#20
Nikoo Cheraghi, Mariko Yasuda, April Deng, Jeffrey Mailhot
No abstract text is available yet for this article.
July 2016: Cutis; Cutaneous Medicine for the Practitioner
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