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erythema nodosum

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https://www.readbyqxmd.com/read/29234719/compression-stockings-as-an-effective-treatment-for-erythema-nodosum-case-series
#1
K B Golisch, S P Gottesman, R J Segal
Erythema nodosum (EN) is a septal panniculitis that is characterized clinically by tender, erythematous, subcutaneous nodules that are predominately localized on the pretibial lower legs. EN affects women more than men and can be idiopathic or secondary to another disease process such as infection or an immune response. Treatment options for erythema nodosum are suboptimal and often involve significant side effects or require a change in lifestyle. We investigated the effects of moderate 20 mmHg to 30 mmHg compression stockings as an alternative treatment method in two female patients with recurrent erythema nodosum...
December 2017: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/29204408/necrotic-erythema-nodosum-leprosum-healing-with-extensive-scars
#2
Chandra S Sirka, Maitreyee Panda, Swetalina Pradhan, Manas R Baisakh
No abstract text is available yet for this article.
November 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29194792/mucocutaneous-manifestations-of-inflammatory-bowel-disease-in-central-china-a-single-center-study
#3
C X Kou, Y Y Zhang, G W Li, J Li, Q T Kong, J Chen, F Liu, M Zhang, F Y Wang, Y Jiang, L Y Hao, J A Ren, H Sang
Inflammatory bowel disease (IBD) is a group of idiopathic inflammatory conditions affecting the gastrointestinal tract, which consists of Crohn's disease (CD) and ulcerative colitis (UC). IBD has multiple extraintestinal manifestations (EIMs), and the prevalence of mucocutaneous manifestations in IBD has been reported as 21%-41%1 . This study aimed at investigating the prevalence of mucocutaneous manifestations (recurrent aphthous ulcer [RAU], erythema nodosum [EN], psoriasis and pyoderma gangrenosum [PG]) of IBD and analyzing of the associations of diseases in a large treatment center of central China...
December 1, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29182760/expression-patterns-of-tnf%C3%AE-madcam1-and-stat3-in-intestinal-and-skin-manifestations-of-inflammatory-bowel-disease
#4
Stephan R Vavricka, Jose A Galván, Heather Dawson, Alex Soltermann, Luc Biedermann, Michael Scharl, Alain M Schoepfer, Gerhard Rogler, Mareike B Prinz Vavricka, Luigi Terracciano, Alexander Navarini, Inti Zlobec, Alessandro Lugli, Thomas Greuter
Background: Pathogenesis of cutaneous extraintestinal manifestations (EIM) in inflammatory bowel disease (IBD) remains elusive. Efficacy of anti-TNF agents suggests TNF-dependent mechanisms. The role of other biologics such as anti-integrins or JAK-inhibitors is not yet clear. Methods: We performed immunohistochemistry for TNFα, NFκB, STAT1/STAT3, MAdCAM1, CD20/68, caspase 3/9, IFNγ, Hsp-27/70 on 240 intestinal (55 controls, 185 IBD) and 64 skin biopsies (11 controls, 18 Erythema nodosum (EN), 13 Pyoderma gangenosum (PG), 22 psoriasis)...
November 22, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29181207/mycoplasma-pneumonia-an-unrecognized-cause-of-fever-of-unknown-origin-in-an-adult
#5
Fatima Ali-Ahmed, Alexandra Halalau
A 26-year-old female was admitted for fever of unknown origin (FUO), headaches, left ankle edema, and a lower extremity rash consistent with erythema nodosum. She had no respiratory symptoms or family history of autoimmune diseases. A chest X-ray was negative for pneumonia or hilar adenopathy. Extensive autoimmune workup was negative. A chest, abdomen, and pelvis computed tomography scan was unremarkable and laboratory studies revealed no source of infection. On hospital day 5, the patient developed a mild productive cough...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/29151337/coexistence-of-idiopathic-granulomatous-mastitis-and-erythemanodosum-successful-treatment-with-corticosteroids
#6
Murat Akın, Harun Karabacak, Güldal Esendağlı, Aydın Yavuz, Serap Gültekin, Kürşat Dikmen, Hasan Bostancı
Background/aim: Idiopathic granulomatous mastitis (IGM) is a rare, chronic inflammatory disease of the breast. Erythema nodosum (EN) is a rare extramammary manifestation of IGM. The purpose of this study is to determine the clinical and demographic characteristics of 11 IGM and EN patients and to evaluate the efficacy of methylprednisolone treatment. Materials and methods: In our series, ten patients had EN bilaterally, whereas one patient had a lesion of the right pretibial area. The mean age of the patients was 35...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29090057/leprosy-presenting-with-iridocyclitis-a-diagnostic-dilemma
#7
Jaya Kaushik, Vaibhav Kumar Jain, Jitendra Kumar Singh Parihar, Sanjay Dhar, Savita Agarwal
PURPOSE: To report a case of lepromatous iridocyclitis that posed a diagnostic challenge. CASE REPORT: A 50-yeasr-old male developed profound loss of vision in the right eye, while he was in the hospital with septicemia presenting with fever, dysuria, and abdominal swelling. He also developed erythema nodosum on the legs. Skin incisional biopsy section, upon dermatology consultation, showed a granulomatous nodule in the dermis. The anterior chamber aspirate demonstrated lepra bacilli, which confirmed the diagnosis of lepromatous leprosy with type II reaction...
October 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/29028793/clinico-pathological-features-of-erythema-nodosum-leprosum-a-case-control-study-at-alert-hospital-ethiopia
#8
Edessa Negera, Stephen L Walker, Selfu Girma, Shimelis N Doni, Degafe Tsegaye, Saba M Lambert, Munir H Idriss, Yohanis Tsegay, Hazel M Dockrell, Abraham Aseffa, Diana N Lockwood
BACKGROUND: Leprosy reactions are a significant cause of morbidity in leprosy population. Erythema nodosum leprosum (ENL) is an immunological complication affecting approximately 50% of patients with lepromatous leprosy (LL) and 10% of borderline lepromatous (BL) leprosy. ENL is associated with clinical features such as skin lesions, neuritis, arthritis, dactylitis, eye inflammation, osteitis, orchitis, lymphadenitis and nephritis. ENL is treated mainly with corticosteroids and corticosteroids are often required for extended periods of time which may lead to serious adverse effects...
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29016342/case-report-histoplasmosis-in-himachal-pradesh-india-an-emerging-endemic-focus
#9
Vikram K Mahajan, Rashmi Kaul Raina, Suman Singh, Rattan Sagar Rashpa, Anuradha Sood, Pushpinder S Chauhan, Karaninder S Mehta, Ritu Rawat, Vikas Sharma
We describe four cases of histoplasmosis indigenous to Himachal Pradesh (India) that will be of considerable public health interest. A 48-year-old human immunodeficiency virus (HIV)-negative man with cervical and mediastinal lymphadenopathy, hepatosplenomegaly, adrenal mass, and bone marrow involvement was treated as disseminated tuberculosis without benefit. Progressive disseminated histoplasmosis was diagnosed from the fungus in smears from adrenal mass. Another 37-year-old HIV-positive man was on treatment of suspected pulmonary tuberculosis...
September 25, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28993983/skin-manifestations-associated-with-autoimmune-liver-diseases-a-systematic-review
#10
REVIEW
Benedetta Terziroli Beretta-Piccoli, Pietro Invernizzi, M Eric Gershwin, Carlo Mainetti
Autoimmune liver diseases, which include mainly autoimmune hepatitis, primary biliary cholangitis, primary sclerosing cholangitis, and the variant syndromes, are often associated with extrahepatic autoimmune diseases. However, the association with cutaneous diseases is less well described. In the present article, we provide a systematic literature review on skin manifestations linked to each of these four autoimmune liver diseases, excluding skin manifestations of systemic diseases. The association of autoimmune hepatitis with vitiligo is well known, with a particular striking association with type 2 autoimmune hepatitis, a condition occurring almost entirely in children and adolescents, much rarer and more aggressive than type 1 autoimmune hepatitis; probable associations are also identified with alopecia areata, psoriasis, and pyoderma gangrenosum...
December 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28992368/unilateral-plantar-erythema-nodosum-in-sarcoidosis
#11
Axel J Hueber, Georg Schett, Bernhard Manger
A 32-year old male Caucasian patient presented with mild exertional dyspnea, pain and swelling of both ankles, and general malaise. On examination symmetrical arthritis of both ankles and a vivid nodular erythema with slight pain on pressure was detected on the sole of the right foot (A). A therapy with ibuprofen had not led to any improvement of symptoms. This article is protected by copyright. All rights reserved.
October 9, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28991896/t-cell-regulation-in-erythema-nodosum-leprosum
#12
Edessa Negera, Stephen L Walker, Kidist Bobosha, Rawleigh Howe, Abraham Aseffa, Hazel M Dockrell, Diana N Lockwood
Leprosy is a disease caused by Mycobacterium leprae where the clinical spectrum correlates with the patient immune response. Erythema Nodosum Leprosum (ENL) is an immune-mediated inflammatory complication, which causes significant morbidity in affected leprosy patients. The underlying cause of ENL is not conclusively known. However, immune-complexes and cell-mediated immunity have been suggested in the pathogenesis of ENL. The aim of this study was to investigate the regulatory T-cells in patients with ENL...
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28973835/aneurysm-formation-after-stent-grafting-in-vascular-behcet-s-disease
#13
Suguru Honda, Fumio Hirano, Mariko Mouri, Hisanori Hasegawa, Hitoshi Kohsaka
A 40-year-old man with a history of oral and ileocecal ulcers, acneiform lesions, erythema nodosum and deep vein thrombosis presented with fever, abdominal pain and a pulsatile mass in the right groin. Two months prior to the presentation, he underwent stent grafting via the right femoral artery for an abdominal aortic aneurysm. Enhanced computed tomography disclosed aneurysms at the both ends of the stent (blue and green arrows in the panels A and B) and at the right femoral puncture site (blue arrowhead)...
October 3, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28969152/azathioprine-in-chronic-recalcitrant-erythema-nodosum-leprosum-a-case-report
#14
Singh Shailendra Vikram Jitendra, Romita Bachaspatimayum, A Subhalakshmi Devi, S Rita
Erythema Nodosum Leprosum (ENL) may have a chronic course which may be recalcitrant to treatment. Preferred treatment modalities are systemic corticosteroids and thalidomide. Azathioprine, methotrexate and cyclosporine are immunosuppressants which may also be used as a steroid sparing agent. We report the case of a 48-year-old male diagnosed as lepromatous leprosy that developed ENL after four months of Multibacillary Multi-Drug Therapy (MB-MDT). He was treated with oral prednisolone (1 mg/kg/day) which was gradually tapered upto a dose of 7...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28966621/new-insight-into-the-pathogenesis-of-erythema-nodosum-leprosum-the-role-of-activated-memory-t-cells
#15
Edessa Negera, Kidist Bobosha, Stephen L Walker, Birtukan Endale, Rawleigh Howe, Abraham Aseffa, Hazel M Dockrell, Diana N Lockwood
Memory T-cells, particularly, effector memory T cells are implicated in the pathogenesis of inflammatory diseases and may contribute to tissue injury and disease progression. Although erythema nodosum leprosum (ENL) is an inflammatory complication of leprosy, the role of memory T cell subsets has never been studied in this patient group. The aim of this study was at investigate the kinetics of memory T cell subsets in patients with ENL before and after prednisolone treatment. A case-control study design was used to recruit 35 untreated patients with ENL and 25 non-reactional lepromatous leprosy (LL) patient controls at ALERT Hospital, Ethiopia...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28965699/-giardia-duodenalis-and-its-involvement-in-skin-diseases
#16
REVIEW
P Humbert, A Guichard, I Bennani, S Chiheb
BACKGOUND: Over the last thirty years, the scientific community has become increasingly interested in the intestinal flora, whether commensal or pathogenic, and its impact on other organs. In dermatology, the correlation between intestinal microbial agents and cutaneous lesions is well established. Giardia duodenalis, an intestinal parasite, has been particularly widely studied. The aim of this work is to provide a review of studies demonstrating the involvement of G. duodenalis in various forms of dermatosis...
November 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28960930/takayasu-arteritis-presented-with-acute-heart-failure-case-report-and-review-of-literature
#17
Xuanqi An, Yechen Han, Bingqing Zhang, Lin Qiao, Yuxing Zhao, Xiaoxiao Guo, Ligang Fang, Wenling Zhu, Quan Fang, Zhujun Shen, Shuyang Zhang
Acute heart failure due to myocarditis is not common in Takayasu arteritis, let alone in combination with thrombosis affecting both ventricles and pulmonary arteries. The concomitant infection of non-tuberculosis mycobacterium further complicates the clinical scenario and poses challenges for implementation of tailored treatments. This case report describes a teenage girl with a history of intermittent claudication and Erythema Nodosum who developed acute heart failure. Detailed clinical investigations and imaging techniques confirmed the diagnosis...
September 28, 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/28954119/etanercept-in-erythema-nodosum-leprosum
#18
Julia Rocha Silva Santos, Dâmia Leal Vendramini, José Augusto da Costa Nery, João Carlos Regazzi Avelleira
One of the biggest challenges in treating leprosy is the control of reaction events. Patients with lepromatous leprosy may present reaction type II, or erythema nodosum leprosum, during treatment, and this reaction can remain in a recurrent form after being released from the hospital, requiring the use of thalidomide and/or prednisone for long periods of time, in turn increasing the risk of side effects. Two reports of the use of antiTNF to treat erythema nodosum leprosum were found in the literature. A good response was found after an assay with infliximab and etanercept...
July 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28944149/a-case-of-leprosy-erythema-nodosum-leprosum-and-hemophagocytic-syndrome-a-continuum-of-manifestations-of-same-agent-host-interactions
#19
Prasan Kumar Panda, Ramjas Prajapati, Arvind Kumar, Manisha Jana, Pradeep Immanuel, Pranay Tanwar, Naveet Wig
A young adult man with 4-years history of lepromatous leprosy (received irregularly multidrug therapy) presented with two and half years history of symptoms suggestive of chronic erythema nodosum leprosum (ENL), initially responded to steroids and thalidomide, but later on failed. During the last 2-months, he developed fever, vomiting, and subsequently altered sensorium. On evaluation, he had hepatosplenomegaly, hyponatremia, hyperferritinemia, hemophagocytosis in bone marrow aspiration, lobular panniculitis in skin biopsy, and multiple parenchymal nodules in chest imaging...
August 2017: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/28901560/erythema-nodosum-like-panniculitis-mimicking-disease-recurrence-a-novel-toxicity-from-immune-checkpoint-blockade-therapy-report-of-2-patients
#20
Michael T Tetzlaff, Amir A Jazaeri, Carlos A Torres-Cabala, Brinda R Korivi, Genie A Landon, Priyadharsini Nagarajan, Adrienne Choksi, Leon Chen, Marc Uemura, Phyu P Aung, Adi Diab, Padmanee Sharma, Michael A Davies, Rodabe Amaria, Victor G Prieto, Jonathan L Curry
Immunotherapies targeting cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and the programmed cell death 1 (PD-1) receptor and its ligand (PD-L1) have showed substantial therapeutic benefit in patients with clinically advanced solid malignancies. However, autoimmune toxicities are common and often significant adverse events with these agents. While rash and pruritus remain the most common cutaneous complications in treated patients, novel dermatologic toxicities related to immune checkpoint blockade continue to emerge as the number of patients exposed to immunotherapy increases...
September 13, 2017: Journal of Cutaneous Pathology
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