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https://www.readbyqxmd.com/read/29909112/a-tale-of-two-tests
#1
EDITORIAL
Pamela S Douglas, Melissa A Daubert
No abstract text is available yet for this article.
June 8, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29905771/a-tale-of-two-forests-ongoing-aridification-drives-population-decline-and-genetic-diversity-loss-at-continental-scale-in-afro-macaronesian-evergreen-forest-archipelago-endemics
#2
Mario Mairal, Juli Caujapé-Castells, Loïc Pellissier, Ruth Jaén-Molina, Nadir Álvarez, Myriam Heuertz, Isabel Sanmartín
Background and Aims: Various studies and conservationist reports have warned about the contraction of the last subtropical Afro-Macaronesian forests. These relict vegetation zones have been restricted to a few oceanic and continental islands around the edges of Africa, due to aridification. Previous studies on relict species have generally focused on glacial effects on narrow endemics; however, little is known about the effects of aridification on the fates of previously widespread subtropical lineages...
June 14, 2018: Annals of Botany
https://www.readbyqxmd.com/read/29899973/a-tale-of-shrimps-genome-wide-survey-of-homeobox-genes-in-120-species-from-diverse-crustacean-taxa
#3
Wai Hoong Chang, Alvina G Lai
The homeodomain-containing proteins are an important group of transcription factors found in most eukaryotes including animals, plants and fungi. Homeobox genes are responsible for a wide range of critical developmental and physiological processes, ranging from embryonic development, innate immune homeostasis to whole-body regeneration. With continued fascination on this key class of proteins by developmental and evolutionary biologists, multiple efforts have thus far focused on the identification and characterization of homeobox orthologs from key model organisms in attempts to infer their evolutionary origin and how this underpins the evolution of complex body plans...
2018: F1000Research
https://www.readbyqxmd.com/read/29894625/a-computational-tale-of-two-enzymes-glycerol-dehydration-with-or-without-b-12
#4
Borislav Kovačević, Danijela Barić, Darko Babic, Luka Bilić, Marko Hanževački, Gregory M Sandala, Leo Radom, David M Smith
We present a series of QM/MM calculations aimed at understanding the mechanism of the biological dehydration of glycerol. Strikingly and unusually, this process is catalyzed by two different radical enzymes, one of which is a coenzyme-B12 - dependent enzyme and the other which is a coenzyme-B12 - independent enzyme. We show that glycerol dehydration in the presence of the coenzyme-B12 -dependent enzyme proceeds via a 1,2-OH shift, which benefits from a significant catalytic reduction in the barrier. In contrast, the same reaction in the presence of the coenzyme-B12 -independent enzyme is unlikely to involve the 1,2-OH shift; instead, a strong preference for direct loss of water from a radical intermediate is indicated...
June 12, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29892187/a-tale-of-two-diseases-or-a-story-of-co-existence-are-obese-individuals-immune-to-alcoholic-liver-disease
#5
Ankur Gupta
No abstract text is available yet for this article.
June 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29889012/dreamland-the-true-tale-of-america-s-opiate-epidemic
#6
Daniel K Partain, Mihir M Kamdar
No abstract text is available yet for this article.
June 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29883470/genomic-integration-and-ligand-dependent-activation-of-the-human-estrogen-receptor-%C3%AE-in-the-crustacean-daphnia-magna
#7
Kerstin Törner, Tsuyoshi Nakanishi, Tomoaki Matsuura, Yasuhiko Kato, Hajime Watanabe
The freshwater crustacean Daphnia have a long history in water quality assessments and now lend themselves to detection of targeted chemicals using genetically encoded reporter gene due to recent progress in the development of genome editing tools. By introducing human genes into Daphnia, we may be able to detect chemicals that affect the human system, or even apply it to screening potentially useful chemicals. Here, we aimed to develop a transgenic line of Daphnia magna that contains the human estrogen receptor alpha (hERα) and shows a fluorescence response to exposure of estrogens...
2018: PloS One
https://www.readbyqxmd.com/read/29880504/a-tale-of-two-countries-women-s-reproductive-rights-in-ireland-and-the-us
#8
EDITORIAL
Dorothy Shaw, Wendy V Norman
No abstract text is available yet for this article.
June 7, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29876906/-transition-from-child-to-adult-epilepsy-difficulties-with-an-objective-that-cannot-be-delayed
#9
C Casas-Fernandez, H Alarcon-Martinez, E Martinez-Salcedo, S Ibanez-Mico
Paediatric care of a chronic process is limited by the moment when the clinical and therapeutic follow-up must be continued by a specialist from the area for adults. The delay in the transition from paediatrics to adult medicine can be due to causes attributable to the patient or his/her relatives, or the professional who diagnosed the disease. The former arises from the uncertainty of facing the unknown, which becomes more intense when the diagnosis and treatment have been difficult, as there is a fear of upsetting the stability of the patient...
June 5, 2018: Revista de Neurologia
https://www.readbyqxmd.com/read/29875154/a-tale-of-two-cities-exploring-the-retail-impact-of-flavoured-tobacco-restrictions-in-the-twin-cities-of-minneapolis-and-saint-paul-minnesota
#10
Betsy Brock, Samantha C Carlson, Alicia Leizinger, Joanne D'Silva, Christine M Matter, Barbara A Schillo
BACKGROUND: Flavoured tobacco is increasingly popular with youth. The twin cities of Minneapolis and Saint Paul, Minnesota restricted the sale of flavoured tobacco to adult-only tobacco shops in an effort to reduce youth access and exposure to these products. This observational study explores the impact of these policies on the retail environment. METHODS: Between November 2015 and April 2017, observational assessments were conducted at convenience and grocery stores preimplementation and postimplementation of flavoured tobacco restrictions in Minneapolis (n=41), Saint Paul (n=37) and the comparison city of Brooklyn Park, Minnesota (n=14)...
June 6, 2018: Tobacco Control
https://www.readbyqxmd.com/read/29874922/cardiovascular-safety-of-psychiatric-agents-a-cautionary-tale
#11
Theodora A Manolis, Antonis A Manolis, Antonis S Manolis
Psychiatric agents are among the most commonly prescribed medications. Despite the advent of newer generation agents, patients receiving them still experience cardiovascular (CV) side effects. However, these agents may have heterogeneous properties, calling for an individualized approach based on efficacy and also on the particular side effect profile of each specific agent. Proarrhythmic effects arising from drug-induced long-QT syndrome and consequent potentially life-threatening polymorphic ventricular arrhythmias in the form of torsade de pointes, the metabolic syndrome contributing to atherosclerosis and acute coronary syndromes, and drug-induced orthostatic hypotension raise major concerns...
January 1, 2018: Angiology
https://www.readbyqxmd.com/read/29874566/hallmarks-of-brain-aging-adaptive-and-pathological-modification-by-metabolic-states
#12
REVIEW
Mark P Mattson, Thiruma V Arumugam
During aging, the cellular milieu of the brain exhibits tell-tale signs of compromised bioenergetics, impaired adaptive neuroplasticity and resilience, aberrant neuronal network activity, dysregulation of neuronal Ca2+ homeostasis, the accrual of oxidatively modified molecules and organelles, and inflammation. These alterations render the aging brain vulnerable to Alzheimer's and Parkinson's diseases and stroke. Emerging findings are revealing mechanisms by which sedentary overindulgent lifestyles accelerate brain aging, whereas lifestyles that include intermittent bioenergetic challenges (exercise, fasting, and intellectual challenges) foster healthy brain aging...
June 5, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29873718/narrative-and-anti-narrative-in-science-how-scientists-tell-stories-and-don-t
#13
Kevin Padian
Narratives are common to all branches of science, not only to the humanities. Scientists tell stories about how the things we study work, develop, and evolve, and about how we come to be interested in them. Here I add a third domain (Secularity) to Gould's two "non-overlapping magisteria" of Science and Religion, and I review previous work on the parallels in elements between story-telling in literature and science. The stories of each domain have different criteria for judging them valid or useful...
June 4, 2018: Integrative and Comparative Biology
https://www.readbyqxmd.com/read/29872518/a-42-year-old-woman-with-subacute-reversible-dementia-a-cautionary-tale
#14
Joseph Kamtchum-Tatuene, Richard Kamwezi, Thokozani Nyalubwe, Josephine P Banda, Gloria Mwangalika, Ian Matandika, Ulla Hemmila, Magnus Tisell, Susanna Koponen, Laura A Benjamin, Patrick Kamalo
A 42-year-old woman presented with a 6-month history of diffuse headache of moderate intensity and gradual onset of generalized weakness, imbalance, apathy, memory decline, hypophonia, dysphagia, constipation and urinary incontinence. Clinical examination revealed several elements of a frontal lobe dysfunction including apathy with motor impersistence, presence of primitive reflexes, generalized hyperreflexia with bilateral Hoffman sign and ankle clonus. The biological workup was unremarkable and a brain computed tomography scan identified a giant olfactory groove meningioma...
September 2017: Malawi Medical Journal: the Journal of Medical Association of Malawi
https://www.readbyqxmd.com/read/29869369/rickets-re-emerging-a-cautionary-tale
#15
N R Arujuna, J Felton
No abstract text is available yet for this article.
June 4, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29859265/cis-trans-engineering-advances-and-perspectives-on-customized-transcriptional-regulation-in-plants
#16
REVIEW
Ankita Shrestha, Ahamed Khan, Nrisingha Dey
Co-ordinated transcriptional control employing synthetic promoters and transcription factors (TFs) can be used to achieve customized gene expression regulation in planta. Synthetic promoter technology has yielded a series of promoters with modified cis-regulatory elements that provide useful tools for efficient modulation of gene expression. In addition, the use of zinc fingers (ZFs), transcription activator-like effectors (TALEs), and catalytically inactive clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein 9 (dCas9) has made it feasible to engineer TFs that can produce targeted gene expression regulation; these approaches are particularly effective when artificial TFs are coupled with transcriptional activators or repressors...
May 30, 2018: Molecular Plant
https://www.readbyqxmd.com/read/29859186/ectopic-expression-of-the-tal-effector-avrxa7-in-xanthomonas-citri-subsp-citri-hinders-citrus-canker-symptom-formation-by-modulating-transcriptional-profile-of-citrus-genes
#17
Dongling Sun, Wei Rou, Yinghui Zhou, Tao Zhuo, Xiaojing Fan, Xun Hu, Huasong Zou
Xanthomonas citri subsp. citri (Xcc) is the causal agent of citrus canker, a serious bacterial disease that affects citrus trees worldwide. The ectopic expression of TAL effector AvrXa7 in Xcc suppressed canker development. The Xcc strain expressing avrXa7 induced a yellow symptom around the inoculation site. Transcriptome analysis revealed 315 differentially expressed genes, which were categorized into several functional groups. The more interesting genes were those involved in the biosynthesis of terpene and ethylene...
May 30, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29859067/the-importance-of-genotype-identity-genetic-heterogeneity-and-bioinformatic-handling-for-properly-assessing-genomic-variation-in-transgenic-plants
#18
Jean-Michel Michno, Robert M Stupar
BACKGROUND: The advent of -omics technologies has enabled the resolution of fine molecular differences among individuals within a species. DNA sequence variations, such as single nucleotide polymorphisms or small deletions, can be tabulated for many kinds of genotype comparisons. However, experimental designs and analytical approaches are replete with ways to overestimate the level of variation present within a given sample. Analytical pipelines that do not apply proper thresholds nor assess reproducibility among samples are susceptible to calling false-positive variants...
June 1, 2018: BMC Biotechnology
https://www.readbyqxmd.com/read/29851684/a-multidisciplinary-approach-to-equipment-use-in-pediatric-patient-mobilization
#19
Katie Parchem, Amanda Peck, Katherine Tales
Research has shown that patients who are mechanically ventilated or immobile for greater than 7 days are at increased risk for deconditioning and muscle atrophy. Immobility impacts length of stay as well as patients' ability to return to their prior level of function. As part of the safe patient-handling initiative created at Michigan Medicine, a special team of nurses and therapists was assembled to adapt an adult mobility framework for the pediatric population. The pediatric mobility model determines each patient's specific mobility "phase" based on detailed criteria...
July 2018: Critical Care Nursing Quarterly
https://www.readbyqxmd.com/read/29851212/a-tale-of-two-eras-phytoplankton-composition-influenced-by-oceanic-paleochemistry
#20
Mario Giordano, Camilla Olivieri, Simona Ratti, Alessandra Norici, John A Raven, Andrew H Knoll
We report the results of simple experiments which support the hypothesis that changes in ocean chemistry beginning in the Mesozoic Era resulted in an increase in the nutritional quality per mole of C and per cell of planktonic algal biomass compared to earlier phytoplankton. We cultured a cyanobacterium, a diatom, a dinoflagellate, and a green alga in media mimicking aspects of the chemistry of Palaeozoic and Mesozoic-Cenozoic oceans. Substantial differences emerged in the quality of algal biomass between the Palaeozoic and Mesozoic-Cenozoic growth regimes; these differences were strongly affected by interspecific interactions (i...
May 30, 2018: Geobiology
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