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https://www.readbyqxmd.com/read/27933602/fish-tales-the-use-of-zebrafish-xenograft-human-cancer-cell-models
#1
REVIEW
Yvette Drabsch, B Ewa Snaar-Jagalska, Peter Ten Dijke
Advances in scientific techniques have provided researchers with exceptional new opportunities to identify and monitor changes between different cancer types, during different stages of progression, between individual tumor cells and in the surrounding stroma. The wealth of information that can be obtained from new scientific techniques places additional requirements on the conventional cancer models. New models that could be used to rapidly access the (potential) functional importance of newly identified (epi)genetic and proteomic changes and test the efficacy on emerging (combinatorial) therapies are desperately required...
December 9, 2016: Histology and Histopathology
https://www.readbyqxmd.com/read/27932809/colgate-partners-with-the-author-of-aliens-love-underpants-to-launch-two-minute-tales
#2
(no author information available yet)
No abstract text is available yet for this article.
December 9, 2016: British Dental Journal
https://www.readbyqxmd.com/read/27931295/a-janus-tale-of-the-two-faces-of-corticosteroid-therapy-a-potential-for-adverse-effects-versus-a-steroid-sparing-benefit-of-certain-therapies
#3
Joseph A Bellanti, Russell A Settipane
No abstract text is available yet for this article.
November 2016: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/27929016/tales-of-wonder
#4
(no author information available yet)
No abstract text is available yet for this article.
December 7, 2016: Nature
https://www.readbyqxmd.com/read/27928771/healthcare-providers-formative-experiences-with-race-and-black-male-patients-in-urban-hospital-environments
#5
Marie V Plaisime, David J Malebranche, Andrea L Davis, Jennifer A Taylor
OBJECTIVE: We explored health providers' formative personal and professional experiences with race and Black men as a way to assess their potential influence on interactions with Black male patients. METHODS: Utilizing convenience sampling with snowballing techniques, we identified healthcare providers in two urban university hospitals. We compared Black and White providers' experiences based on race and level of training. We used the Gardener's Tale to conceptualize how racism may lead to racial health disparities...
December 7, 2016: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/27927243/traditional-mapuche-ecological-knowledge-in-patagonia-argentina-fishes-and-other-living-beings-inhabiting-continental-waters-as-a-reflection-of-processes-of-change
#6
Juana Aigo, Ana Ladio
BACKGROUND: Understanding how people interpret environmental change and develop practices in response to such change is essential to comprehend human resource use. In the cosmology of the American indigenous peoples, as among the Mapuche people, freshwater systems are considered a living entity, where animals have an enormous role to play in the universe of meaning. However, human adaptive responses to freshwater system dynamics are scarcely examined. In this work a survey is carried out in three Mapuche communities of Argentine Patagonia to assess their traditional knowledge of the fishes and other non-human living beings that inhabit lakes and rivers...
December 7, 2016: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/27927141/a-cautionary-tale-in-forensic-pathology
#7
Michael Burke
No abstract text is available yet for this article.
December 12, 2016: Medical Journal of Australia
https://www.readbyqxmd.com/read/27926841/broken-tales-transcription-activator-like-effectors-populate-partly-folded-states
#8
Kathryn Geiger-Schuller, Doug Barrick
Transcription activator-like effector proteins (TALEs) contain large numbers of repeats that bind double-stranded DNA, wrapping around DNA to form a continuous superhelix. Since unbound TALEs retain superhelical structure, it seems likely that DNA binding requires a significant structural distortion or partial unfolding. In this study, we use nearest-neighbor "Ising" analysis of consensus TALE (cTALE) repeat unfolding to quantify intrinsic folding free energies, coupling energies between repeats, and the free energy distribution of partly unfolded states, and to determine how those energies depend on the sequence that determines DNA-specificity (called the "RVD")...
December 6, 2016: Biophysical Journal
https://www.readbyqxmd.com/read/27924885/a-tale-of-two-worlds
#9
Mara Hvistendahl
No abstract text is available yet for this article.
August 16, 2016: Scientific American
https://www.readbyqxmd.com/read/27916153/onco-cardiology-a-tale-of-interplay-between-2-families-of-diseases
#10
EDITORIAL
Sadeer G Al-Kindi, Guilherme H Oliveira
No abstract text is available yet for this article.
December 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27913030/confounding-variables-and-the-performance-of-triggers-in-detecting-unreported-adverse-drug-reactions
#11
Fabiana Rossi Varallo, Carolina Dagli-Hernandez, Caroline Pagotto, Tales Rubens de Nadai, Maria Teresa Herdeiro, Patricia de Carvalho Mastroianni
PURPOSE: This study explored the performance of trigger in detecting adverse drug reactions (ADRs), the confounding variables impairing the causal association of the ADRs, and the underreporting rate by hospital health professionals. METHODS: A 6-month cross-sectional study was conducted in a public general hospital. Data collection was conducted in 2 stages: (1) screening of patient hospitalizations to identify suspected ADRs with 9 triggers developed by the Institute of Healthcare Improvement; and (2) chart review to perform the causality assessment of the suspected ADRs identified, to describe the confounding variables associated with detection of suspected ADRs that were not drug induced, and to analyze the positive predictive value of triggers in recognizing ADRs...
November 29, 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/27911715/the-control-of-inflammation-via-the-phosphorylation-and-dephosphorylation-of-tristetraprolin-a-tale-of-two-phosphatases
#12
REVIEW
Andrew R Clark, Jonathan L E Dean
Twenty years ago, the first description of a tristetraprolin (TTP) knockout mouse highlighted the fundamental role of TTP in the restraint of inflammation. Since then, work from several groups has generated a detailed picture of the expression and function of TTP. It is a sequence-specific RNA-binding protein that orchestrates the deadenylation and degradation of several mRNAs encoding inflammatory mediators. It is very extensively post-translationally modified, with more than 30 phosphorylations that are supported by at least two independent lines of evidence...
October 15, 2016: Biochemical Society Transactions
https://www.readbyqxmd.com/read/27910763/il10-a-tale-of-an-evolutionarily-conserved-cytokine-across-vertebrates
#13
M Carla Piazzon, George Lutfalla, Maria Forlenza
IL10 was discovered in 1989, and since then it has been the subject of intense investigation, which has revealed its potent anti-inflammatory and regulatory activities in most immune processes during infection and disease. In 2003, the first non-mammalian IL10 sequence was identified in teleost fish, followed in 2004 by the chicken IL10 sequence. In this review, we summarize the work performed in non-mammalian vertebrates in which the IL10, IL10 receptors (IL10Rs), and their signaling components have been identified...
2016: Critical Reviews in Immunology
https://www.readbyqxmd.com/read/27907892/the-parallel-tales-of-microvascular-angina-and-heart-failure-with-preserved-ejection-fraction-a-paradigm-shift
#14
Filippo Crea, C Noel Bairey Merz, John F Beltrame, Juan Carlos Kaski, Hisao Ogawa, Peter Ong, Udo Sechtem, Hiroaki Shimokawa, Paolo G Camici
No abstract text is available yet for this article.
October 23, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27902405/microbial-nanowires-an-electrifying-tale
#15
Sandeep K Sure, Leigh M Ackland, Angel A Torriero, Alok Adholeya, Mandira Kochar
Electromicrobiology has gained momentum in the last ten years with advances in microbial fuel cells and the discovery of microbial nanowires (MNWs). The list of MNWs producing microorganisms is growing and providing intriguing insights into the presence of such microorganisms in diverse environments and the potential roles MNWs can perform. This review discusses the MNWs produced by different microorganisms, including their structure, composition and role in electron transfer through MNWs. Two hypotheses, metallic-like conductivity and an electron hopping model, have been proposed for electron transfer and we present a current understanding of both these hypotheses...
October 21, 2016: Microbiology
https://www.readbyqxmd.com/read/27897678/a-tale-of-two-temporal-coding-strategies-common-and-dissociable-brain-regions-involved-in-recency-versus-associative-temporal-order-retrieval-strategies
#16
Jennifer S Lieberman, Colin T Kyle, Amber Schedlbauer, Jared Stokes, Arne D Ekstrom
Numerous studies indicate the importance of the hippocampus to temporal order retrieval. However, behavioral studies suggest that there are different ways to retrieve temporal order information from encoded sequences, one involving an associative strategy (retrieving associations using neighboring items in a list) and another involving a recency strategy (determining which of two items came first). It remains unresolved, however, whether both strategies recruit the hippocampus or only associative strategies, consistent with the hippocampus's role in relational processing...
November 29, 2016: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/27897124/an-acid-tale-of-prion-formation
#17
Mick F Tuite
Some bacteria use lactic acid to communicate with yeast cells.
November 29, 2016: ELife
https://www.readbyqxmd.com/read/27890262/what-is-the-role-of-novel-thrombopoietic-agents-in-the-management-of-acute-leukemia
#18
REVIEW
David J Kuter
The role of novel thrombopoietic agents in the management of acute leukemia is a tale of two molecules, romiplostim and eltrombopag. Both are thrombopoietin (TPO) receptor agonists with somewhat different mechanisms of action. Romiplostim is a peptide TPO receptor agonist that activates the TPO receptor by binding to it just like TPO. Eltrombopag is a nonpeptide TPO receptor agonist that activates the TPO receptor by binding to the transmembrane domain. Both TPO receptor agonists increase platelet counts in healthy humans and in those with immune thrombocytopenia...
December 2016: Best Practice & Research. Clinical Haematology
https://www.readbyqxmd.com/read/27889274/a-tale-of-2-hiv-outbreaks-caused-by-unsafe-injections-in-cambodia-and-the-united-states-2014-2015
#19
Runa H Gokhale, Romeo R Galang, John P Pitman, John T Brooks
No abstract text is available yet for this article.
November 23, 2016: American Journal of Infection Control
https://www.readbyqxmd.com/read/27888952/a-tale-of-two-perspectives-on-cancer-what-i-wish-i-knew-before-cancer-radiologist-and-patient-perspectives
#20
Jennifer Kemp, Christine Zars
No abstract text is available yet for this article.
December 2016: Journal of the American College of Radiology: JACR
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