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Nick Marriner, David Kaniewski, Christophe Morhange, Clément Flaux, Matthieu Giaime, Matteo Vacchi, James Goff
From 2000 to 2015, tsunamis and storms killed more than 430,000 people worldwide and affected a further >530 million, with total damages exceeding US$970 billion. These alarming trends, underscored by the tragic events of the 2004 Indian Ocean catastrophe, have fueled increased worldwide demands for assessments of past, present, and future coastal risks. Nonetheless, despite its importance for hazard mitigation, discriminating between storm and tsunami deposits in the geological record is one of the most challenging and hotly contended topics in coastal geoscience...
October 2017: Science Advances
Kevin Cheung, Manraj N Kaur, Tyson Tolliver, Christopher J Longo, Nash H Naam, Achilles Thoma
PURPOSE: Canadian health care is often criticized for extended wait times, whereas the United States suffers from increased costs. The purpose of this pilot study was to determine the cost-utility of open carpal tunnel release in Canada versus the United States. METHODS: A prospective cohort study evaluated patients undergoing open carpal tunnel release at an institution in Canada and the United States. All costs from a societal perspective were captured. Utility was measured using validated health-related quality of life (HRQOL) scales-the EuroQol-5D and the Michigan Hand Outcome Questionnaire...
February 2017: Plastic Surgery
Yuan Zhang, Lulu Liu, Shengjie Guo, Jinghui Song, Chenxu Zhu, Zongwei Yue, Wensheng Wei, Chengqi Yi
DNA recognition by transcription activator-like effector (TALE) proteins is mediated by tandem repeats that specify nucleotides through repeat-variable diresidues. These repeat-variable diresidues form direct and sequence-specific contacts to DNA bases; hence, TALE-DNA interaction is sensitive to DNA chemical modifications. Here we conduct a thorough investigation, covering all theoretical repeat-variable diresidue combinations, for their recognition capabilities for 5-methylcytosine and 5-hydroxymethylcytosine, two important epigenetic markers in higher eukaryotes...
October 12, 2017: Nature Communications
Sudheer Tale, Bharath A Chhabria, Atit A Gawalkar, Hanuma N Banavath, Ashish Bhalla
No abstract text is available yet for this article.
August 4, 2017: QJM: Monthly Journal of the Association of Physicians
A A Gawalkar, S Tale, B A Chhabria, A Bhalla
No abstract text is available yet for this article.
July 14, 2017: QJM: Monthly Journal of the Association of Physicians
Jane Peart, Glen Thomson, Stephen Wood
The developing asymmetry has a 12-15% risk of malignancy but poses challenges of detection and interpretation due to the lack of typical features of cancer and the frequent absence of an ultrasound correlate. Failure to biopsy these lesions may lead to delayed diagnosis of breast cancer.
October 11, 2017: Journal of Medical Imaging and Radiation Oncology
Rita Azeredo, Marina Machado, António Afonso, Camino Fierro-Castro, Felipe E Reyes-López, Lluis Tort, Manuel Gesto, Marta Conde-Sieira, Jesús M Míguez, José L Soengas, Eva Kreuz, Sven Wuertz, Helena Peres, Aires Oliva-Teles, Benjamin Costas
Methionine and tryptophan appear to be fundamental in specific cellular pathways involved in the immune response mechanisms, including stimulation of T-regulatory cells by tryptophan metabolites or pro-inflammatory effects upon methionine supplementation. Thus, the aim of this study was to evaluate the immunomodulatory effect of these amino acids on the inflammatory and neuroendocrine responses in juveniles of European seabass, Dicentrarchus labrax. To achieve this, goal fish were fed for 14 days methionine and tryptophan-supplemented diets (MET and TRP, respectively, 2× dietary requirement level) or a control diet meeting the amino acids requirement levels (CTRL)...
2017: Frontiers in Immunology
Kayla Riswold, Valerie Flynn
No abstract text is available yet for this article.
October 6, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Donald H Gutteridge, Frank L Mastaglia
An 82-year-old woman with polymyalgia rheumatica (PMR) on prednisone 7 mg daily was admitted to an acute stroke unit with a right homonymous hemianopia, a left posterior cerebral artery occlusion and occipital lobe infarct. She had raised inflammatory markers, did not have a temporal artery biopsy, and was discharged on the same dose of prednisone. After 21 months, off prednisone, her ophthalmologist, concerned about giant cell arteritis (GCA), restarted prednisone 40 mg daily, with rapid, profound visual improvement...
October 2017: Internal Medicine Journal
Pankaj Jain, Roslyn A Prichard, Mark B Connellan, Kumud K Dhital, Peter S Macdonald
In this 'paired' case report, we describe two heart transplants performed 3 days apart at our centre. Both cases involved very prolonged transportation time of the donor heart. In one case, the donor heart was transported in an ice chest, while in the other case the organ was transported using a normothermic ex vivo perfusion (NEVP) system. The additional retrieval costs incurred by the use NEVP were more than offset by the reduction in subsequent inpatient costs.
October 2017: Internal Medicine Journal
Shuyi Zhang, Bin Guo, Anlan Dong, Jing He, Ziping Xu, Song Xi Chen
The official air-quality statistic reported that Beijing had a 9.9% decline in the annual concentration of PM2.5 in 2016. While this statistic offered some relief for the inhabitants of the capital, we present several analyses based on Beijing's PM2.5 data of the past 4 years at 36 monitoring sites along with meteorological data of the past 7 years. The analyses reveal the air pollution situation in 2016 was not as rosy as the 9.9% decline would convey, and improvement if any was rather uncertain. The paper also provides an assessment on the city's PM2...
September 2017: Proceedings. Mathematical, Physical, and Engineering Sciences
Elizabeth Liao, David Carr
BACKGROUND: African tick-bite fever is an increasingly common cause for fever in the returning traveller. It needs to be considered in the febrile returning traveller with a characteristic rash: a black eschar. CASE REPORT: We describe a 51-year-old man returning from South Africa who presented to our emergency department with fever, headache, myalgia, and chills. On careful history and skin examination, a black eschar was found on the patient's left lateral shoulder, pointing toward a diagnosis of African tick-bite fever...
October 5, 2017: Journal of Emergency Medicine
Anna Torrens-Burton, Nasreen Basoudan, Antony J Bayer, Andrea Tales
This study examines the relationships between two measures of information processing speed associated with executive function (Trail Making Test and a computer-based visual search test), the perceived difficulty of the tasks, and perceived memory function (measured by the Memory Functioning Questionnaire) in older adults (aged 50+ y) with normal general health, cognition (Montreal Cognitive Assessment score of 26+), and mood. The participants were recruited from the community rather than through clinical services, and none had ever sought or received help from a health professional for a memory complaint or mental health problem...
October 3, 2017: Journal of Alzheimer's Disease: JAD
Javier De Las Rivas, Cesar Bonavides-Martínez, Francisco Jose Campos-Laborie
Owing to the emerging impact of bioinformatics and computational biology, in this article, we present an overview of the history and current state of the research on this field in Latin America (LA). It will be difficult to cover without inequality all the efforts, initiatives and works that have happened for the past two decades in this vast region (that includes >19 million km2 and >600 million people). Despite the difficulty, we have done an analytical search looking for publications in the field made by researchers from 19 LA countries in the past 25 years...
June 28, 2017: Briefings in Bioinformatics
Roberta Sarno, Yoan Vicq, Norio Uematsu, Marine Luka, Clement Lapierre, Dana Carroll, Giacomo Bastianelli, Alexandre Serero, Alain Nicolas
Meiotic recombination shapes the genetic diversity transmitted upon sexual reproduction. However, its non-random distribution along the chromosomes constrains the landscape of potential genetic combinations. For a variety of purposes, it is desirable to expand the natural repertoire by changing the distribution of crossovers in a wide range of eukaryotes. Toward this end, we report the local stimulation of meiotic recombination at a number of chromosomal sites by tethering the natural Spo11 protein to various DNA-binding modules: full-length DNA binding proteins, zinc fingers (ZFs), transcription activator-like effector (TALE) modules, and the CRISPR-Cas9 system...
August 24, 2017: Nucleic Acids Research
Karen Clauß, Achim P Popp, Lena Schulze, Johannes Hettich, Matthias Reisser, Laura Escoter Torres, N Henriette Uhlenhaut, J Christof M Gebhardt
Transcription comprises a highly regulated sequence of intrinsically stochastic processes, resulting in bursts of transcription intermitted by quiescence. In transcription activation or repression, a transcription factor binds dynamically to DNA, with a residence time unique to each factor. Whether the DNA residence time is important in the transcription process is unclear. Here, we designed a series of transcription repressors differing in their DNA residence time by utilizing the modular DNA binding domain of transcription activator-like effectors (TALEs) and varying the number of nucleotide-recognizing repeat domains...
August 21, 2017: Nucleic Acids Research
Maria Célia Cunha Ciaccia, Camila Nazareth Pinto, Fernanda da Costa Golfieri, Tales Ferreira Machado, Lívia Lopes Lozano, João Marcel Sanseverino Silva, Vera Esteves Vagnozzi Rullo
OBJECTIVE: To evaluate the prevalence of genu valgum and associated factors in elementary school students. METHODS: Cross-sectional study, carried out in 2015, with 1,050 children and adolescents enrolled in an elementary school in Santos, Southeast Brazil. Misalignment of the knee was assessed by intermalleolar distance, considering ≥8 cm or <8 cm. Inter-examiners reliability was measured by Kappa coefficient, resulting in 0.94. Nutritional status was evaluated according to the World Health Organization 2006 references...
September 21, 2017: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
Yonglong Chen, Yougong Peng, Shijie Fan, Yimin Li, Zhi-Xiong Xiao, Chenghua Li
As a member of tumor suppressor p53 family, p63, a gene encoding versatile protein variant, has been documented to correlate with cancer formation and progression, though it is rarely mutated in cancer patients. However, it has long been controversial on whether p63 is an oncogene or a tumor suppressor. Here, we comprehensively reviewed reports on roles of p63 in development, tumorigenesis and tumor progression. According to data from molecular cell biology, genetic models and clinic research, we conclude that p63 may act as either an oncogene or a tumor suppressor gene in different scenarios: TA isoforms of p63 gene are generally tumor-suppressive through repressing cell proliferation, survival and metastasis; ΔN isoforms, however, may initiate tumorigenesis via promoting cell proliferation and survival, but inhibit tumor metastasis and progression; effects of p63 on tumor formation and progression depend on the context of the whole p53 family, and either amplification or loss of p63 gene locus can break the balance to cause tumorigenesis...
October 3, 2017: Cellular and Molecular Life Sciences: CMLS
L Vutskits, J W Sall
No abstract text is available yet for this article.
September 1, 2017: British Journal of Anaesthesia
Javier De Las Rivas, Cesar Bonavides-Martínez, Francisco Jose Campos-Laborie
No abstract text is available yet for this article.
September 2, 2017: Briefings in Bioinformatics
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