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https://www.readbyqxmd.com/read/28334601/a-tale-of-two-inputs
#1
James Ashley, Vivian Budnik
In this issue of Neuron, Newman et al. (2017) image calcium events at single synapses of unanesthetized Drosophila larvae. Synaptic plasticity and homeostatic regulation of synapses is established to be input specific. Furthermore, plasticity forms involve selective recruitment of previously active or silent synapses.
March 22, 2017: Neuron
https://www.readbyqxmd.com/read/28334119/climbing-the-yeast-cell-wall
#2
Enrico Cabib
Here is a life in three countries, with different cultures, different political structures and even different skies. The constant through all these changes is the addiction of the subject of this story to science and laboratory work. Perhaps the tale that unfolds here will show to some beginners in research that persistence, seasoned with a little luck, can bring results and satisfaction in the long run.
February 25, 2017: FEMS Yeast Research
https://www.readbyqxmd.com/read/28331882/cryptogenic-multifocal-ulcerous-stenosing-enteritis-cmuse-a-tale-of-three-decades
#3
Ayaskanta Singh, Manoj Kumar Sahu, Manas Kumar Panigrahi, Debasis Misra
We present a patient who, over the course of 35 years, presented with repeated episodes of ileus and melena and was misdiagnosed several times, leading to several surgeries. Macroscopic and microscopic features of his resected intestine were compatible with cryptogenic multifocal ulcerous stenosis enteritis (CMUSE), but additional angioectatic lesions were also noted. The patient responded dramatically to hormonal therapy consisting of ethinylestradiol and norethisterone. To our knowledge, this is the first reported case of CMUSE that has shown response to hormonal therapy...
2017: ACG Case Reports Journal
https://www.readbyqxmd.com/read/28328358/the-cautionary-tale-of-the-initial-widespread-foray-into-psychiatric-genetics
#4
Michael James Redinger, Tyler S Gibb, Perry Westerman
No abstract text is available yet for this article.
April 2017: American Journal of Bioethics: AJOB
https://www.readbyqxmd.com/read/28327791/a-tale-of-two-neglected-tropical-infections-using-gis-to-assess-the-spatial-and-temporal-overlap-of-schistosomiasis-and-leprosy-in-a-region-of-minas-gerais-brazil
#5
David Alexander Phillips, José Antonio Ferreira, Deidra Ansah, Herica Sa Teixeira, Uriel Kitron, Thelma de Filippis, Marcelo H de Alcântara, Jessica K Fairley
BACKGROUND: Despite public health efforts to reduce the global burden of leprosy, gaps remain in the knowledge surrounding transmission of infection. Helminth co-infections have been associated with a shift towards the lepromatous end of the disease spectrum, potentially increasing transmission in co-endemic areas. OBJECTIVES: Using this biologically plausible association, we conducted a geographic information systems (GIS) study to investigate the spatial associations of schistosomiasis and leprosy in an endemic area of Minas Gerais (MG), Brazil...
April 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28327517/combined-pre-distortion-and-censoring-for-bandwidth-efficient-and-energy-efficient-fusion-of-spectrum-sensing-information
#6
Guilherme Pedro Aquino, Dayan Adionel Guimarães, Luciano Leonel Mendes, Tales Cleber Pimenta
This paper describes a novel scheme for the fusion of spectrum sensing information in cooperative spectrum sensing for cognitive radio applications. The scheme combines a spectrum-efficient, pre-distortion-based fusion strategy with an energy-efficient censoring-based fusion strategy to achieve the combined effect of reduction in bandwidth and power consumption during the transmissions of the local decisions to the fusion center. Expressions for computing the key performance metrics of the spectrum sensing of the proposed scheme are derived and validated by means of computer simulations...
March 22, 2017: Sensors
https://www.readbyqxmd.com/read/28326694/tales-from-the-acfi-dementia-in-residential-aged-care
#7
Jenni Joenperä
OBJECTIVE: Provide an overview of how care needs in permanent residential aged care differ by dementia status. METHODS: On entry into permanent residential aged care, people's care needs are assessed on the Aged Care Funding Instrument (ACFI). ACFI also captures health conditions that are considered to affect the cost of people's care, such as dementia. Data were compared between 2009 and 2015. RESULTS: Assessed care needs have increased regardless of dementia status...
March 2017: Australasian Journal on Ageing
https://www.readbyqxmd.com/read/28322463/a-tale-of-tale-prep1-pbx1-and-meis1-interconnections-and-competition-in-cancer
#8
REVIEW
Francesco Blasi, Chiara Bruckmann, Dmitry Penkov, Leila Dardaei
We report the latest structural information on PREP1 tumor suppressor, the specific "oncogene" and "tumor suppressive" signatures of MEIS1 and PREP1, the molecular rules regulating PREP1 and MEIS1 binding to DNA, and how these can change depending on the interaction with PBX1, cell-type, neoplastic transformation, and intracellular concentration. As both PREP1 and MEIS1 interact with PBX1 they functionally compete with each other. PREP1, PBX1, and MEIS1 TALE-class homeodomain transcription factors act in an interdependent and integrated way in experimental tumorigenesis...
March 21, 2017: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
https://www.readbyqxmd.com/read/28320051/tale-of-two-cancers-don-t-forget-the-synchronous-colon-cancer
#9
Ju Yong Cheong, Raymond Oliphant, Anil Keshava
No abstract text is available yet for this article.
March 20, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28302693/langerhans-cell-histiocytosis-in-a-patient-with-hairy-cell-leukemia-a-tale-of-divergence
#10
Sanam Loghavi, Joseph D Khoury
No abstract text is available yet for this article.
March 16, 2017: Blood
https://www.readbyqxmd.com/read/28301511/dissection-of-tale-dependent-gene-activation-reveals-that-they-induce-transcription-cooperatively-and-in-both-orientations
#11
Jana Streubel, Heidi Baum, Jan Grau, Johannes Stuttman, Jens Boch
Plant-pathogenic Xanthomonas bacteria inject transcription activator-like effector proteins (TALEs) into host cells to specifically induce transcription of plant genes and enhance susceptibility. Although the DNA-binding mode is well-understood it is still ambiguous how TALEs initiate transcription and whether additional promoter elements are needed to support this. To systematically dissect prerequisites for transcriptional initiation the activity of one TALE was compared on different synthetic Bs4 promoter fragments...
2017: PloS One
https://www.readbyqxmd.com/read/28301269/the-long-tale-of-the-calcium-activated-cl-channels-in-olfactory-transduction
#12
Michele Dibattista, Simone Pifferi, Anna Boccaccio, Anna Menini, Johannes Reisert
Ca(2+)-activated Cl(-) currents have been implicated in many cellular processes in different cells, but for many years, their molecular identity remained unknown. Particularly intriguing are Ca(2+)-activated Cl(-) currents in olfactory transduction, first described in the early 90s. Well characterized electrophysiologically, they carry most of the odorant-induced receptor current in the cilia of olfactory sensory neurons (OSNs). After many attempts to determine their molecular identity, TMEM16B was found to be abundantly expressed in the cilia of OSNs in 2009 and having biophysical properties like those of the native olfactory channel...
March 16, 2017: Channels
https://www.readbyqxmd.com/read/28295259/applying-the-tor-c-que-in-inkt-cells-a-new-twist-in-an-old-tale
#13
Mihalis Verykokakis, Barbara L Kee
The mammalian Target of Rapamycin (mTOR) protein controls the machinery necessary for T-cell activation, differentiation, and memory formation, as a component of mTOR complex 1 (mTORC1) and mTORC2, which function both downstream and upstream of AKT. Invariant natural killer T (iNKT) cells are a unique T-cell subset that exist in a primed state, capable of rapid activation, and produce large quantities of cytokines. iNKT-cell effector differentiation is dependent on the mTORC1 complex; however, the requirements for mTORC2 in iNKT cells have been controversial...
March 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28291324/nanosalina-a-tale-of-saline-loving-algae-from-the-lake-s-agony-to-cancer-therapy
#14
Fatemeh Ostadhossein, Santosh K Misra, Aaron Schwartz-Duval, Brajendra K Sharma, Dipanjan Pan
The nanoparticles (NPs) that contain the therapeutic agent within themselves without further modifications can be coined as 'self-therapeutic' NPs. The development of these agents especially when derived from natural resources can lead to a paradigm shift in the field of cancer nanotechnology as they can immensely facilitate the complex chemistry procedures and the follow up biological complications. Herein, we demonstrate that inherently therapeutic NPs 'integrating' β-carotene can be synthesized from Dunaliella Salina microalgae in a single step without complicated chemistry...
March 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28287728/characterization-of-biomolecular-helices-and-their-complementarity-using-geometric-analysis
#15
Kevin Hauser, Yiqing He, Miguel Garcia-Diaz, Carlos Simmerling, Evangelos A Coutsias
A general method is presented to characterize the helical properties of potentially irregular helices, such as those found in protein secondary and tertiary structures, and nucleic acids. The method was validated using artificial helices with varying numbers of points, points per helical turn, pitch and radius. The sensitivity of the method was validated by applying increasing amounts of random perturbation to the coordinates of these helices; 399,360 helices in total were evaluated. In addition, the helical parameters of protein secondary structure elements and nucleic acid helices were analyzed...
March 13, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28287193/medico-legal-notes-for-a-new-set-of-standards-in-the-assessment-of-penal-liability-in-psychiatry
#16
Gianluca Montanari Vergallo, Raffaella Rinaldi, Giuseppe Bersani, Enrico Marinelli
Negligence liability on the part of a psychiatrist belongs among high-complexity fields, for both the judge and his or her technical consultants. In most instances, there are no scientific grounds in order to ascribe with reasonable certainty liability to medical personnel and nursing staff, while often judges tend to stretch the concept of “protection” to a degree to which the psychiatrist is deemed to have a legal obligation to stave off the development of any adverse consequence which psychic distress may bring upon the patient...
January 2017: Rivista di Psichiatria
https://www.readbyqxmd.com/read/28281540/t-ell-tale-signs-of-aging
#17
Reshma Taneja, Brian K Kennedy
Transcriptional activator-like effectors (TALEs) have emerged as powerful tools for genome editing. A recent study published by Cell Research reports that fusion of thioredoxin to TALEs unlocks their full potential in live-cell imaging to accurately analyze genome instability, telomere attrition and epigenetic alterations that are hallmarks of aging.
March 10, 2017: Cell Research
https://www.readbyqxmd.com/read/28279550/tale-of-2-health-care-systems-disparities-in-demographic-and-clinical-characteristics-between-2-ischemic-stroke-populations-in-los-angeles-county
#18
Amytis Towfighi, Erica Patel, Nerses Sanossian, Natalie P Valle, Bruce Ovbiagele
BACKGROUND: Individuals who present to the emergency departments of safety-net systems often have poorly controlled risk factors due to lack of primary care. Little is known about potential differences in presenting characteristics, discharge medications, and discharge destinations of patients with acute ischemic stroke (AIS) who present to safety-net settings versus university medical centers (UMCs). METHODS: Demographic characteristics, medical history, premorbid medication use, stroke severity, discharge medications, and discharge destination were assessed among consecutive admissions for AIS over a 2-year period at a UMC (n = 385) versus 2 university-affiliated safety-net hospitals (SNHs) (n = 346) in Los Angeles County...
March 6, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28278737/the-tell-tale-heart-physiological-reactivity-during-resolution-of-ambiguity-in-youth-anxiety
#19
Michelle Rozenman, Allison Vreeland, Marisela Iglesias, Melissa Mendez, John Piacentini
In the past decade, cognitive biases and physiological arousal have each been proposed as mechanisms through which paediatric anxiety develops and is maintained over time. Preliminary studies have found associations between anxious interpretations of ambiguity, physiological arousal, and avoidance, supporting theories that link cognition, psychophysiology, and behaviour. However, little is known about the relationship between youths' resolutions of ambiguity and physiological arousal during acute stress. Such information may have important clinical implications for use of verbal self-regulation strategies and cognitive restructuring during treatments for paediatric anxiety...
February 16, 2017: Cognition & Emotion
https://www.readbyqxmd.com/read/28278463/band-selection-for-nonlinear-unmixing-of-hyperspectral-images-as-a-maximal-clique-problem
#20
Tales Imbiriba, Jose Carlos Bermudez, Cedric Richard
Kernel-based nonlinear mixing models have been applied to unmix spectral information of hyperspectral images when the type of mixing occurring in the scene is too complex or unknown. Such methods, however, usually require the inversion of matrices of sizes equal to the number of spectral bands. Reducing the computational load of these methods remains a challenge in large scale applications. This paper proposes a centralized band selection (BS) method for supervised unmixing in the reproducing kernel Hilbert space (RKHS)...
March 1, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
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