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https://www.readbyqxmd.com/read/28648244/the-tales-athletes-tell-narrative-structure-and-identity-in-great-british-medalists
#1
Tristan J Coulter, Clifford J Mallett, Jefferson A Singer
Using a life story approach, Hardy and colleagues present a study examining the similarities and differences in the psychosocial development of UK-based elite and super-elite athletes. We found this work to be a highly personal account into the lives of these cohorts, which advances knowledge concerning the psychology and influencing events and circumstances that separate the good from the great performers. We make some suggestions for how to enrich the study's findings and approach, by (1) adopting McAdams' multilayer framework of personality, as an overarching structure for assessing the whole person, and (2) encouraging the authors to explore the narrative structure of the presented life stories and go beyond simply an interpretation of their content...
2017: Progress in Brain Research
https://www.readbyqxmd.com/read/28647023/how-i-became-a-clinician-scientist-in-dermatology-a-tale-of-serendipity-wise-mentors-and-a-good-pinch-of-tenacity
#2
EDITORIAL
Thomas Krieg
No abstract text is available yet for this article.
July 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28646088/closing-the-brief-case-a-fishy-tale-prevents-digital-doom-following-polly-s-peck-the-importance-of-pets-in-a-comprehensive-medical-history
#3
EDITORIAL
P A Simpson, M Przybylo, T J Blanchard, T Wingfield
No abstract text is available yet for this article.
July 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28646087/the-brief-case-a-fishy-tale-prevents-digital-doom-following-polly-s-peck-the-importance-of-pets-in-a-comprehensive-medical-history
#4
EDITORIAL
P A Simpson, M Przybylo, T J Blanchard, T Wingfield
No abstract text is available yet for this article.
July 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28643557/pooled-sample-testing-for-bonamia-ostreae-a-tale-of-two-sybr-green-real-time-pcr-assays
#5
Henry S Lane, J Brian Jones, Wendy L McDonald
Pooled testing of samples is a common laboratory practice to increase efficiency and reduce expenses. We investigated the efficacy of 2 published SYBR Green real-time PCR assays when used to detect the haplosporidian parasite Bonamia ostreae in pooled samples of infected oyster tissue. Each PCR targets a different gene within the B. ostreae genome: the actin 1 gene or the 18S rRNA gene. Tissue homogenates (150 mg) of the New Zealand flat oyster Ostrea chilensis were spiked with ~1.5 × 10(3) purified B. ostreae cells to create experimental pools of 3, 5, and 10...
June 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28643263/genome-editing-of-the-ascidian-ciona-intestinalis-with-tale-nuclease
#6
Yasunori Sasakura, Keita Yoshida, Nicholas Treen
The ascidian Ciona intestinalis is an important model animal for studying developmental mechanisms for constructing the chordate body. Although molecular and embryological techniques for manipulating Ciona genes were developed a long time ago, recent achievements of genome editing in this animal have innovated functional analyses of genes in Ciona. Particularly, knockout of genes in the G0 generation coupled with tissue-specific expression of TALENs enables us to rapidly address gene functions that were difficult using previous methods...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28643257/genome-editing-mediated-by-primordial-germ-cell-in-chicken
#7
Jae Yong Han, Hong Jo Lee
Rapid development of genome editing technology has facilitated the studies on exploring specific gene functions and establishment of model animals. In livestock, the technology has contributed to create high value in industry fields, e.g., enhancing productivity or acquiring the resistance against disease. Meanwhile, genome editing in avian species has been emphasized because of their applicable possibilities in terms of highly productive chickens, disease-controlled avian lines, and development of novel biological models...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28643246/current-overview-of-talen-construction-systems
#8
Tetsushi Sakuma, Takashi Yamamoto
Transcription activator-like effector (TALE) nuclease (TALEN) is the second-generation genome editing tool consisting of TALE protein containing customizable DNA-binding repeats and nuclease domain of FokI enzyme. Each DNA-binding repeat recognizes one base of double-strand DNA, and functional TALEN can be created by a simple modular assembly of these repeats. To easily and efficiently assemble the highly repetitive DNA-binding repeat arrays, various construction systems such as Golden Gate assembly, serial ligation, and ligation-independent cloning have been reported...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28640276/teeth-tell-tale-of-hippo-s-quick-spread-across-africa
#9
Traci Watson
No abstract text is available yet for this article.
June 20, 2017: Nature
https://www.readbyqxmd.com/read/28637681/two-tales-of-cytauxzoon-felis-infections-in-domestic-cats
#10
REVIEW
Jin-Lei Wang, Ting-Ting Li, Guo-Hua Liu, Xing-Quan Zhu, Chaoqun Yao
Cytauxzoonosis is an emerging infectious disease that affects wild felids as well as the domestic cat; it is caused by the apicomplexan protozoan parasites belonging to the genus Cytauxzoon. Cytauxzoonfelis is the species of major concern, whose transmission occurs via the bite of an infected tick. Cytauxzoonosis of the domestic cat has historically been considered uniformly fatal, with a short course of illness, and most domestic cats die within 9 to 15 days postinfection. However, increasing evidence of domestic cats surviving C...
October 2017: Clinical Microbiology Reviews
https://www.readbyqxmd.com/read/28637323/evolution-of-transcription-activator-like-effectors-in-xanthomonas-oryzae
#11
Annett Erkes, Maik Reschke, Jens Boch, Jan Grau
Transcription activator-like effectors (TALEs) are secreted by plant-pathogenic Xanthomonas bacteria into plant cells where they act as transcriptional activators and, hence, are major drivers in reprogramming the plant for the benefit of the pathogen. TALEs possess a highly repetitive DNA-binding domain of typically 34 amino acid tandem repeats, where amino acid 12 and 13, termed repeat variable di-residue (RVD), determine target specificity. Different Xanthomonas strains possess different repertoires of TALEs...
June 14, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28627202/infrapeso-materno-y-resultados-perinatales-estudio-de-cohortes-retrospectivo
#12
Ángel Vilar Sánchez, Juan Jesús Fernández Alba, María Del Carmen González Macías, María Del Carmen Paublete Herrera, Concepción Carnicer Fuentes, Florentino Carral San Laureano, Rafael Torrejón Cardoso, Luis Javier Moreno Corral
Introducción: algunos estudios han asociado el infrapeso materno con resultados perinatales adversos tales como aborto espontáneo, desprendimiento placentario, feto pequeño para edad gestacional, crecimiento intrauterino retardado y parto pretérmino.Objetivos: determinar si el infrapeso materno al inicio de la gestación influye sobre la forma de inicio y vía del parto, peso al nacer, índice de Apgar al minuto 5 y edad gestacional en el momento del parto.Métodos: estudio de cohortes retrospectivo en gestantes adscritas al Hospital Universitario de Puerto Real...
June 5, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28623587/generation-of-dtales-and-libraries-of-synthetic-tale-activated-promoters-for-engineering-of-gene-regulatory-networks-in-plants
#13
Tom Schreiber, Alain Tissier
Transcription factors with programmable DNA-binding specificity constitute valuable tools for the design of orthogonal gene regulatory networks for synthetic biology. Transcription activator-like effectors (TALEs), as natural transcription regulators, were used to design, build, and test libraries of synthetic TALE-activated promoters (STAPs) that show a broad range of expression levels in plants. In this chapter, we present protocols for the construction of artificial TALEs and corresponding STAPs.
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28623498/minimal-barcode-distance-between-two-water-mite-species-from-madeira-island-a-cautionary-tale
#14
Ricardo García-Jiménez, Jose Luis Horreo, Antonio G Valdecasas
In this work, we compare morphological and molecular data in their ability to distinguish between species of water mites (Acari, Prostigmata, Hydrachnidia). We have focused on the two species of the genus Lebertia inhabiting the island of Madeira. While traditional morphological traits were initially sufficient to distinguish between these two species, the molecular data were more dependable on the kind of analysis carried out. Single arbitrary genetic distance (e.g. a K2P distance below 2%) may lead to the conclusion that the specimens under study belong to the same species...
June 16, 2017: Experimental & Applied Acarology
https://www.readbyqxmd.com/read/28622760/fawcett-j-m-risko-e-f-kingstone-a-eds-the-handbook-of-attention-fawcett-j-m-risko-e-f-kingstone-a-eds-the-handbook-of-attention-cambridge-ma-usa-mit-press-2015-696-pp-isbn-9780262029698-%C3%A2-57-95-hardcover
#15
https://www.readbyqxmd.com/read/28621262/a-peptide-antagonist-of-prep1-p160-interaction-improves-ceramide-induced-insulin-resistance-in-skeletal-muscle-cells
#16
Ilaria Cimmino, Virginia Lorenzo, Francesca Fiory, Nunzianna Doti, Serena Ricci, Serena Cabaro, Antonietta Liotti, Luigi Vitagliano, Michele Longo, Claudia Miele, Pietro Formisano, Francesco Beguinot, Menotti Ruvo, Francesco Oriente
Prep1 is a homeodomain transcription factor belonging to the TALE protein family. Its overexpression affects glucose metabolism in several tissues. In particular, in skeletal muscle tissue the interaction of Prep1 with its cofactor p160 impairs GLUT4 expression and glucose uptake.In this study, we show that ceramides (C2cer), a class of lipids antagonizing insulin signalling, increase the levels of Prep1 and p160 in a dose and time-dependent fashion in L6 cells and induce their association by 80%. We find that C2cer exposure inhibits insulin receptor, IRS1 and Akt phosphorylation and reduces insulin-stimulated glycogen content and glucose uptake by 1...
May 30, 2017: Oncotarget
https://www.readbyqxmd.com/read/28617970/trends-in-the-prevalence-of-neural-tube-defects-a-tale-of-two-policies
#17
Babak Khoshnood, Nathalie Lelong
No abstract text is available yet for this article.
June 15, 2017: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/28617832/a-tale-inspired-computational-screen-for-proteins-that-contain-approximate-tandem-repeats
#18
Malgorzata Perycz, Joanna Krwawicz, Matthias Bochtler
TAL (transcription activator-like) effectors (TALEs) are bacterial proteins that are secreted from bacteria to plant cells to act as transcriptional activators. TALEs and related proteins (RipTALs, BurrH, MOrTL1 and MOrTL2) contain approximate tandem repeats that differ in conserved positions that define specificity. Using PERL, we screened ~47 million protein sequences for TALE-like architecture characterized by approximate tandem repeats (between 30 and 43 amino acids in length) and sequence variability in conserved positions, without requiring sequence similarity to TALEs...
2017: PloS One
https://www.readbyqxmd.com/read/28617333/an-%C3%A2-aukward-tale-a-genetic-approach-to-discover-the-whereabouts-of-the-last-great-auks
#19
Jessica E Thomas, Gary R Carvalho, James Haile, Michael D Martin, Jose A Samaniego Castruita, Jonas Niemann, Mikkel-Holger S Sinding, Marcela Sandoval-Velasco, Nicolas J Rawlence, Errol Fuller, Jon Fjeldså, Michael Hofreiter, John R Stewart, M Thomas P Gilbert, Michael Knapp
One hundred and seventy-three years ago, the last two Great Auks, Pinguinusimpennis, ever reliably seen were killed. Their internal organs can be found in the collections of the Natural History Museum of Denmark, but the location of their skins has remained a mystery. In 1999, Great Auk expert Errol Fuller proposed a list of five potential candidate skins in museums around the world. Here we take a palaeogenomic approach to test which-if any-of Fuller's candidate skins likely belong to either of the two birds...
June 15, 2017: Genes
https://www.readbyqxmd.com/read/28614681/a-tale-of-two-doctors-structural-inequalities-and-the-culture-of-medicine
#20
Louise Aronson
I recently had two doctor’s appointments in the same week, one in general medicine and the other in orthopedics, both at the same highly ranked medical institution. Occurring so close together, these visits quickly morphed in my mind from personal experiences with individual doctors into metaphors..
June 15, 2017: New England Journal of Medicine
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