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https://www.readbyqxmd.com/read/28821181/conservation-genetics-of-the-cheetah-lessons-learned-and-new-opportunities
#1
Stephen J O'Brien, Warren E Johnson, Carlos A Driscoll, Pavel Dobrynin, Laurie Marker
The dwindling wildlife species of our planet have become a cause célèbre for conservation groups, governments, and concerned citizens throughout the world. The application of powerful new genetic technologies to surviving populations of threatened mammals has revolutionized our ability to recognize hidden perils that afflict them. We have learned new lessons of survival, adaptation, and evolution from viewing the natural history of genomes in hundreds of detailed studies. A single case history of one species, the African cheetah, Acinonyx jubatus, is here reviewed to reveal a long-term story of conservation challenges and action informed by genetic discoveries and insights...
September 1, 2017: Journal of Heredity
https://www.readbyqxmd.com/read/28819046/tuberculous-tales-an-east-london-experience
#2
REVIEW
Apeksha M Shah, Dominika Raciborska, Matthew Stevens, Sharmilee Gnanapavan, Veronica L C White, Benjamin Turner
Tuberculous meningitis presents a diagnostic and therapeutic challenge, and considering its long history and increasing global incidence, the evidence base for its treatment is relatively scanty. Many UK neurologists will have little first-hand experience of this deadly condition, and if faced with a patient with possible tuberculous meningitis will find decision making less than straightforward. In parts of East London (UK) the rates of tuberculosis and tuberculous meningitis are among the highest in Western Europe, and so the neurologists and respiratory physicians at the Royal London Hospital have encountered many such patients over the years...
August 17, 2017: Practical Neurology
https://www.readbyqxmd.com/read/28817295/does-the-offer-of-free-prescriptions-increase-generic-prescribing
#3
Bruce Stuart, Franklin Hendrick, J Samantha Dougherty, Jing Xu
OBJECTIVES: To test if offering zero generic co-pays for oral antidiabetic drugs (OADs) and statins increases generic dispensing for low-income subsidy (LIS) recipients with diabetes enrolled in Medicare Part D. STUDY DESIGN: We analyzed a natural experiment in which LIS recipients were randomized to Part D plans in 2008. Some plans placed selected generic OADs and statins on zero co-pay tiers whereas others did not. Randomization eliminated selection effects which could bias the study findings...
June 1, 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/28813069/atualiza%C3%A3-%C3%A3-o-da-diretriz-brasileira-de-dislipidemias-e-preven%C3%A3-%C3%A3-o-da-aterosclerose-%C3%A2-2017
#4
André Arpad Faludi, Maria Cristina de Oliveira Izar, José Francisco Kerr Saraiva, Ana Paula Marte Chacra, Henrique Tria Bianco, Abrahão Afiune, Adriana Bertolami, Alexandre C Pereira, Ana Maria Lottenberg, Andrei C Sposito, Antonio Carlos Palandri Chagas, Antonio Casella, Antônio Felipe Simão, Aristóteles Comte de Alencar, Bruno Caramelli, Carlos Costa Magalhães, Carlos Eduardo Negrão, Carlos Eduardo Dos Santos Ferreira, Carlos Scherr, Claudine Maria Alves Feio, Cristiane Kovacs, Daniel Branco de Araújo, Daniel Magnoni, Daniela Calderaro, Danielle Menosi Gualandro, Edgard Pessoa de Mello, Elizabeth Regina Giunco Alexandre, Emília Inoue Sato, Emilio Hideyuki Moriguchi, Fabiana Hanna Rached, Fábio César Dos Santos, Fernando Henpin Yue Cesena, Francisco Antonio Helfenstein Fonseca, Henrique Andrade Rodrigues da Fonseca, Hermes Toros Xavier, Isabela Cardoso Pimentel Mota, Isabela de Carlos Back Giuliano, Jaqueline Scholz Issa, Jayme Diament, João Bosco Pesquero, José Ernesto Dos Santos, José Rocha Faria, José Xavier de Melo, Juliana Tieko Kato, Kerginaldo Paulo Torres, Marcelo Chiara Bertolami, Marcelo Heitor Vieira Assad, Márcio Hiroshi Miname, Marileia Scartezini, Neusa Assumpta Forti, Otávio Rizzi Coelho, Raul Cavalcante Maranhão, Raul Dias Dos Santos, Renato Jorge Alves, Roberta Lara Cassani, Roberto Tadeu Barcellos Betti, Tales de Carvalho, Tânia Leme da Rocha Martinez, Viviane Zorzanelli Rocha Giraldez, Wilson Salgado
No abstract text is available yet for this article.
July 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28806768/design-and-fabrication-of-a-realistic-anthropomorphic-heterogeneous-head-phantom-for-mr-purposes
#5
Sossena Wood, Narayanan Krishnamurthy, Tales Santini, Shailesh Raval, Nadim Farhat, John Andy Holmes, Tamer S Ibrahim
OBJECTIVE: The purpose of this study is to design an anthropomorphic heterogeneous head phantom that can be used for MRI and other electromagnetic applications. MATERIALS AND METHODS: An eight compartment, physical anthropomorphic head phantom was developed from a 3T MRI dataset of a healthy male. The designed phantom was successfully built and preliminarily evaluated through an application that involves electromagnetic-tissue interactions: MRI (due to it being an available resource)...
2017: PloS One
https://www.readbyqxmd.com/read/28801318/from-dna-binding-to-transcriptional-activation-is-the-tale-complete
#6
Nicoletta Bobola
How transcription factors (TFs) control enhancer and promoter functions to effect changes in gene expression is an important question. In this issue, Hau et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201701154) show that the TALE TF MEIS recruits the histone modifier PARP1/ARTD1 at promoters to decompact chromatin and activate transcription.
August 11, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28799640/from-a-story-of-pain-a-tale-of-love-for-patients-and-science
#7
Andrea Ferrari, Maura Massimino
No abstract text is available yet for this article.
August 7, 2017: Tumori
https://www.readbyqxmd.com/read/28795350/-so-far-like-the-present-period-a-reply-to-c-h-waddington-s-differences-with-the-creators-of-the-modern-evolutionary-synthesis-a-tale-of-two-genes
#8
Erik L Peterson
No abstract text is available yet for this article.
August 9, 2017: History and Philosophy of the Life Sciences
https://www.readbyqxmd.com/read/28793820/ischemic-conditioning-attenuates-platelet-mediated-thrombosis-a-tale-of-reverse-translation
#9
Karin Przyklenk, Peter Whittaker
Data obtained in both preclinical models and humans have revealed that the favorable cardiac consequences of ischemic conditioning extend beyond a direct effect on the cardiomyocyte. In the current review, we summarize our as-yet limited understanding of the complex relationships between ischemic conditioning, platelet activation-aggregation, and cardioprotection.
September 2017: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28791592/c-h-waddington-s-differences-with-the-creators-of-the-modern-evolutionary-synthesis-a-tale-of-two-genes
#10
Jonathan B L Bard
In 2011, Peterson suggested that the main reason why C.H. Waddington was essentially ignored by the framers of the modern evolutionary synthesis in the 1950s was because they were Cartesian reductionists and mathematical population geneticists while he was a Whiteheadian organicist and experimental geneticist who worked with Drosophila. This paper suggests a further reason that can only be seen now. The former defined genes and their alleles by their selectable phenotypes, essentially the Mendelian view, while Waddington defined a gene through its functional role as determined by genetic analysis, a view that foresaw the modern view that a gene is a DNA sequence with some function...
August 8, 2017: History and Philosophy of the Life Sciences
https://www.readbyqxmd.com/read/28790040/two-tales-of-cardiovascular-risks-middle-aged-women-living-in-sweden-and-scotland-a-cross-sectional-comparative-study
#11
Carina Wennerholm, Catherine Bromley, AnnaKarin Johansson, Staffan Nilsson, John Frank, Tomas Faresjö
OBJECTIVES: To compare cardiovascular risk factors as well as rates of cardiovascular diseases in middle-aged women from urban areas in Scotland and Sweden. DESIGN: Comparative cross-sectional study. SETTING: Data from the general population in urban areas of Scotland and the general population in two major Swedish cities in southeast Sweden, south of Stockholm. PARTICIPANTS: Comparable data of middle-aged women (40-65 years) from the Scottish Health Survey (n=6250) and the Swedish QWIN study (n=741) were merged together into a new dataset (n=6991 participants)...
August 7, 2017: BMJ Open
https://www.readbyqxmd.com/read/28789821/fetal-death-certificate-data-quality-a-tale-of-two-u-s-counties
#12
Lauren Christiansen-Lindquist, Robert M Silver, Corette B Parker, Donald J Dudley, Matthew A Koch, Uma M Reddy, George R Saade, Robert L Goldenberg, Carol J R Hogue
PURPOSE: Describe the relative frequency and joint effect of missing and misreported fetal death certificate (FDC) data and identify variations by key characteristics. METHODS: Stillbirths were prospectively identified during 2006-2008 for a multisite population-based case-control study. For this study, eligible mothers of stillbirths were not incarcerated residents of DeKalb County, Georgia, or Salt Lake County, Utah, aged ≥13 years, with an identifiable FDC...
July 20, 2017: Annals of Epidemiology
https://www.readbyqxmd.com/read/28781180/long-term-trends-of-surface-water-mercury-and-methylmercury-concentrations-downstream-of-historic-mining-within-the-carson-river-watershed
#13
Eric D Morway, Carl E Thodal, Mark Marvin-DiPasquale
The Carson River is a vital water resource for local municipalities and migratory birds travelling the Pacific Flyway. Historic mining practices that used mercury (Hg) to extract gold from Comstock Lode ore has left much of the river system heavily contaminated with Hg, a practice that continues in many parts of the world today. Between 1998 and 2013, the United States Geological Survey (USGS) collected and analyzed Carson River water for Hg and methylmercury (MeHg) concentrations resulting in a sixteen year record of unfiltered total mercury (uf...
August 3, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28779851/a-tale-of-two-sites-differential-impairment-of-frequency-and-duration-mismatch-negativity-across-a-primarily-inpatient-versus-a-primarily-outpatient-site-in-schizophrenia
#14
Migyung Lee, Pejman Sehatpour, Elisa C Dias, Gail S Silipo, Joshua T Kantrowitz, Antigona M Martinez, Daniel C Javitt
Deficits in mismatch negativity (MMN) generation are among the best replicated neurophysiological deficits in schizophrenia, with reduced amplitude reflecting impaired information processing at the level of supratemporal auditory cortex. Differential patterns of MMN dysfunction according to deviant types have been reported across studies, with some research groups showing impairment in duration MMN but not frequency MMN, and other research groups reporting both findings. We evaluate the hypothesis that recruitment setting, reflecting current functional status, might be an important determinant of the pattern of MMN dysfunction...
August 2, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28769146/what-does-a-swiss-franc-mortgage-cost-the-tale-of-polish-trust-for-foreign-currency-denominated-mortgages-implications-for-well-being-and-health
#15
Piotr Białowolski, Dorota Węziak-Białowolska
It is commonly agreed that excessive household financial debts are detrimental to psychological and physical health. Research also demonstrates that housing instability, mortgage indebtedness and mortgage foreclosure negatively influence subjective well-being. In Poland at the beginning of 2015, homeowners with Swiss franc denominated mortgages suffered from an abrupt swing in the Swiss franc/Polish zloty (CHF/PLN) exchange rate, which resulted in considerable increase in the local currency value of their mortgages...
2017: Social Indicators Research
https://www.readbyqxmd.com/read/28765484/double-whammy-a-tale-of-two-malignancies
#16
Abhishek Sharma, Paul Devakar Yesudian
No abstract text is available yet for this article.
July 31, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28753598/genetics-new-tales-from-ancient-dna
#17
Vivien Marx
No abstract text is available yet for this article.
July 28, 2017: Nature Methods
https://www.readbyqxmd.com/read/28752793/a-tale-of-two-norms-the-impact-of-normative-sample-selection-criteria-on-standardized-scores-in-older-adults
#18
Phillip K Martin, Ryan W Schroeder, Lyle E Baade
OBJECTIVE: Normative sample composition can vary notably as a function of exclusionary criteria in older adult samples given that typical medical conditions of exclusion become more prevalent with age. Older adult norms may consist of typically aging or healthy aging individuals according to the stringency of the exclusion criteria, a difference illustrated when comparing two normative samples for the RBANS: the original standardization sample and the Oklahoma sample. METHODS: The current study examined the clinical impact of norm selection in older adults by analyzing impairment classification rates for 105 older adult behavioral health inpatients...
July 28, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28750800/lipidomics-a-corrective-lens-for-enzyme-myopia
#19
Heather B Bradshaw, Emma Leishman
Classifications and characterizations of specific proteins, such as enzymes, not only allow us to understand biosynthetic and metabolic pathways but they also help to drive our understanding of protein structure and function. How those characterizations are evaluated, however, may change our interpretations and lead us into broader and novel directions in research. Here, we will make the argument that using lipidomics as a tool for characterizing enzymatic function over more traditional toolkit options allows for these types of revelations...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28745213/emerging-roles-of-meis1-in-cardiac-regeneration-stem-cells-and-cancer
#20
Merve Aksoz, Raife Dilek Turan, Esra Albayrak, Fatih Kocabas
Meis1 is a member of three-amino-acid loop extension (TALE) homeodomain transcription factors. Studies in the last decade have shown that Meis1 has crucial roles in cardiac regeneration, stem cell function, and tumorigenesis. We have recently demonstrated that knocking out of Meis1 in adult cardiomyocytes resulted in the induction of cardiomyocyte proliferation. This suggests that targeting of Meis1 might be utilized in the manipulation of cardiomyocyte cell cycle post cardiac injuries. In addition, hematopoietic stem cell (HSC) specific deletion of Meis1 leads to in vivo expansion of HSCs pool...
July 24, 2017: Current Drug Targets
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