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https://www.readbyqxmd.com/read/28432167/a-tale-of-two-vasculitides-biopsy-proven-giant-cell-arteritis-followed-by-the-independent-development-of-renal-limited-microscopic-polyangiitis
#1
Roman Zuckerman, Mayur Patel, Deborah R Alpert
We describe an 80-year-old woman who presented with headaches, bilateral jaw claudication and visual symptoms. She was diagnosed with giant cell arteritis, which was confirmed by temporal artery biopsy. She was treated with high-dose prednisone followed by a slow taper, with complete resolution of symptoms. Approximately 4 years later, she developed progressively worsening renal function associated with haematuria. Serological workup revealed a high-titre perinuclear antinuclear cytoplasmic antibody and antibodies to myeloperoxidase...
April 21, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28426748/tails-of-the-travelling-gaussian-model-and-the-relative-age-effect-tales-of-age-discrimination-and-wasted-talent
#2
John R Doyle, Paul A Bottomley, Rob Angell
The Relative Age Effect (RAE) documents the inherent disadvantages of being younger rather than older in an age-banded cohort, typically a school- or competition-year, to the detriment of career-progression, earnings and wellbeing into adulthood. We develop the Tails of the Travelling Gaussian (TTG) to model the mechanisms behind RAE. TTG has notable advantages over existing approaches, which have been largely descriptive, potentially confounded, and non-comparable across contexts. In Study 1, using data from the UK's Millennium Cohort Study, we investigate the different levels of RAE bias across school-level academic subjects and "personality" traits...
2017: PloS One
https://www.readbyqxmd.com/read/28421807/los-antioxidantes-en-el-proceso-de-patolog%C3%A3-as-oculares
#3
Ana Fernández-Araque, Andrea Giaquinta Aranda, Consuelo Laudo Pardo, Abel Rojo Aragüés
Introducción: la influencia de los antioxidantes en los procesos oculares ha tomado en los últimos años una relevancia importante por sus efectos en la salud visual. El estrés oxidativo es un factor implicado en el desarrollo de las principales patologías tales como cataratas, glaucoma y degeneración macular asociada a la edad (DMAE).Objetivo: establecer la evidencia científica que existe sobre los distintos tipos de antioxidantes y sus efectos en procesos patológicos oculares mediante una revisión sistemática...
March 30, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28421104/evolving-tale-of-tcps-new-paradigms-and-old-lacunae
#4
REVIEW
Namrata Dhaka, Vasudha Bhardwaj, Manoj K Sharma, Rita Sharma
Teosinte Branched1/Cycloidea/Proliferating cell factors (TCP) genes are key mediators of genetic innovations underlying morphological novelties, stress adaptation, and evolution of immune response in plants. They have a remarkable ability to integrate and translate diverse endogenous, and environmental signals with high fidelity. Compilation of studies, aimed at elucidating the mechanism of TCP functions, shows that it takes an amalgamation and interplay of several different factors, regulatory processes and pathways, instead of individual components, to achieve the incredible functional diversity and specificity, demonstrated by TCP proteins...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28418485/the-living-donor-a-tale-of-money-mania-and-clinical-mastery
#5
Dean Schillinger
No abstract text is available yet for this article.
April 18, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28403871/a-systematic-tale-of-two-differing-reviews-evaluating-the-evidence-on-public-and-private-sector-quality-of-primary-care-in-low-and-middle-income-countries
#6
Jorge Coarasa, Jishnu Das, Elizabeth Gummerson, Asaf Bitton
Systematic reviews are powerful tools for summarizing vast amounts of data in controversial areas; but their utility is limited by methodological choices and assumptions. Two systematic reviews of literature on the quality of private sector primary care in low and middle income countries (LMIC), published in the same journal within a year, reached conflicting conclusions. The difference in findings reflects different review methodologies, but more importantly, a weak underlying body of literature. A detailed examination of the literature cited in both reviews shows that only one of the underlying studies met the gold standard for methodological robustness...
April 12, 2017: Globalization and Health
https://www.readbyqxmd.com/read/28402579/glitch-in-the-switch
#7
Joey Berlin
Migrating patient records from one electronic health record system to another can be a nightmare. A La Porte pediatrician's experience provides a cautionary tale for all physicians.
April 1, 2017: Texas Medicine
https://www.readbyqxmd.com/read/28397914/improving-target-amino-acid-selectivity-in-a-permissive-aminoacyl-trna-synthetase-through-counter-selection
#8
Itthipol Sungwienwong, Zachary M Hostetler, Robert J Blizzard, Joseph J Porter, Camden M Driggers, Lea Z Mbengi, José A Villegas, Lee C Speight, Jeffery G Saven, John J Perona, Rahul M Kohli, Ryan A Mehl, E James Petersson
The amino acid acridon-2-ylalanine (Acd) can be a valuable probe of protein dynamics, either alone or as part of a Förster resonance energy transfer (FRET) or photo-induced electron transfer (eT) probe pair. We have previously reported the genetic incorporation of Acd by an aminoacyl tRNA synthetase (RS). However, this RS, developed from a library of permissive RSs, also incorporates N-phenyl-aminophenylalanine (Npf), a trace byproduct of one Acd synthetic route. We have performed negative selections in the presence of Npf and analyzed the selectivity of the resulting AcdRSs by in vivo protein expression and detailed kinetic analyses of the purified RSs...
April 11, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28393120/raman-identification-of-cuneiform-tablet-pigments-emphasis-and-colour-technology-in-ancient-mesopotamian-mid-third-millennium
#9
Daniele Chiriu, Pier Carlo Ricci, Carlo Maria Carbonaro, Davide Nadali, Andrea Polcaro, Paul Collins
Cuneiform tablets tell the life and culture of Sumerian people in a sort of black and white tale because of the binary engraving technique. A leading question arises: did Mesopotamian people apply some kind of colour to decorate their tablets or to put emphasis on selected words? Some administrative and literary Sumerian cuneiform tablets of mid-third Millennium B.C. from the site of Kish (central Mesopotamia, modern Iraq) were dug up in twentieth-century and stored at the Ashmolean Museum of the Oxford University...
March 2017: Heliyon
https://www.readbyqxmd.com/read/28386265/unexpected-cartilage-phenotype-in-cd4-cre-conditional-sos-deficient-mice
#10
Geoffrey Guittard, Devorah L Gallardo, Wenmei Li, Nicolas Melis, Julian C Lui, Robert L Kortum, Nicholas G Shakarishvili, Sunmee Huh, Jeffrey Baron, Roberto Weigert, Joshua A Kramer, Lawrence E Samelson, Connie L Sommers
RAS signaling is central to many cellular processes and SOS proteins promote RAS activation. To investigate the role of SOS proteins in T cell biology, we crossed Sos1(f/f)Sos2(-/-) mice to CD4-Cre transgenic mice. We previously reported an effect of these mutations on T cell signaling and T cell migration. Unexpectedly, we observed nodules on the joints of greater than 90% of these mutant mice at 5 months of age, especially on the carpal joints. As the mice aged further, some also displayed joint stiffness, hind limb paralysis, and lameness...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28385281/dermatology-of-the-heart-tales-from-the-pericardial-sac
#11
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
April 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28384283/correction-dissection-of-tale-dependent-gene-activation-reveals-that-they-induce-transcription-cooperatively-and-in-both-orientations
#12
Jana Streubel, Heidi Baum, Jan Grau, Johannes Stuttmann, Jens Boch
[This corrects the article DOI: 10.1371/journal.pone.0173580.].
2017: PloS One
https://www.readbyqxmd.com/read/28383221/refleksjonsgrupper-%C3%A2-en-metode-for-kvalitetssikring
#13
Tale Norbye Wien, Ingrid Hyldmo, Nina Lang, Vegard Vevatne, Elin Fjerstad, Lill Karin Mensen, Arnstein Finset
No abstract text is available yet for this article.
April 2017: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
https://www.readbyqxmd.com/read/28381118/the-factor-structure-of-the-hopkins-symptoms-checklist-hscl-25-in-a-student-population-a-cautionary-tale
#14
Jens C Skogen, Simon Øverland, Otto R F Smith, Leif E Aarø
AIMS: The Hopkins Symptoms Checklist (HSCL-25) is a widely used self-report measurement for mental health problems, but its factor structure is still uncertain, with divergent results in different social or cultural settings. We aimed to investigate the previously suggested factor structures of the HSCL-25, as well as a model including an explicit somatic factor among students in Norway. METHODS: The study population is based on data from the Norwegian study of students' health and wellbeing, SHoT ('Studentenes Helse- og Trivselsundersøkelse'), and the present study comprises N = 13,525 participants...
April 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/28380140/-management-practices-in-medium-sized-private-hospitals-in-s%C3%A3-o-paulo-brazil
#15
Luiz Artur Ledur Brito, Ana Maria Malik, Eliane Brito, Sergio Bulgacov, Tales Andreassi
Traditional management practices are sometimes considered merely a necessary condition for superior performance. Other resources and competencies with higher barriers to imitation are assumed to be potential sources of competitive advantage. This study describes and analyzes the effect of traditional management practices on the performance of medium-sized hospitals. Medium-sized companies frequently display the greatest differences in management practices, and only recently did the hospital sector seek ways to develop its competitiveness in the administrative arena...
April 3, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28379696/nolb-nonlinear-rigid-block-normal-mode-analysis-method
#16
Alexandre Hoffmann, Sergei Grudinin
We present a new conceptually simple and computationally efficient method for nonlinear normal-mode analysis called NOLB. It relies on the rotations-translations of blocks (RTB) theoretical basis developed by Y.-H. Sanejouand and colleagues [ Durand et al. Biopolymers 1994 , 34 , 759 - 771 . Tama et al. Proteins: Struct., Funct., Bioinf . 2000 , 41 , 1 - 7 ]. We demonstrate how to physically interpret the eigenvalues computed in the RTB basis in terms of angular and linear velocities applied to the rigid blocks and how to construct a nonlinear extrapolation of motion out of these velocities...
April 11, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28375504/con-cautionary-tales-and-reservations-about-the-adoption-of-new-technologies-and-biomarkers-for-the-management-of-acute-kidney-injury
#17
Wim Van Biesen
Acute kidney injury (AKI) is an important health-care problem. Over the last decades, many innovative therapies and diagnostic approaches have been tried; however, none of these has been able to confirm consistently that they lead to improved outcomes. Much focus has been placed on intensive care unit (ICU)-associated AKI, whereas the bulk of AKI still concerns patients not in the ICU. Involvement of nephrologists in the care of AKI patients is necessary to further improve outcomes. It is unclear whether new technologies, such as biomarkers, are helpful and could replace nephrology consultation...
March 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28363961/the-tale-of-a-neglected-energy-source-elevated-hydrogen-exposure-affects-both-microbial-diversity-and-function-in-soil
#18
Mondher Khdhiri, Sarah Piché-Choquette, Julien Tremblay, Susannah G Tringe, Philippe Constant
The enrichment of H2-oxidizing bacteria (HOB) by H2 generated by nitrogen-fixing nodules has been shown to have a fertilization effect on several different crops. The benefit of HOB is attributed to their production of plant growth promoting factors, yet their interactions with other members of soil microbial communities have received little attention. Here we report that the energy potential of H2, when supplied to soil, alters ecological niche partitioning of bacteria and fungi, with multifaceted consequences on both generalist and specialist microbial functions...
March 31, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28362528/interpreting-do-not-resuscitate-a-cautionary-tale-of-physician-influence
#19
Joanna L Hart, Meeta Prasad Kerlin
No abstract text is available yet for this article.
April 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28359678/bodyguards-pathogen-derived-decoys-that-protect-virulence-factors
#20
Judith K Paulus, Jiorgos Kourelis, Renier A L van der Hoorn
Recent studies on plant-pathogen interactions have exposed a new strategy used by plant pathogens: decoy effectors that protect virulence factors. Examples of these "bodyguards" include the recently discovered PsXLP1 from Phytophthora sojae and truncated TALEs from Xanthomonas oryzae. These examples suggest important roles for seemingly non-functional effector proteins in distracting the host.
March 27, 2017: Trends in Plant Science
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