Natasha J Anstey, Vijayakumar Kapgal, Shashank Tiwari, Thomas C Watson, Anna K H Toft, Owen R Dando, Felicity H Inkpen, Paul S Baxter, Zrinko Kozić, Adam D Jackson, Xin He, Mohammad Sarfaraz Nawaz, Aiman Kayenaat, Aditi Bhattacharya, David J A Wyllie, Sumantra Chattarji, Emma R Wood, Oliver Hardt, Peter C Kind
BACKGROUND: Mutations in the postsynaptic transmembrane protein neuroligin-3 are highly correlative with autism spectrum disorders (ASDs) and intellectual disabilities (IDs). Fear learning is well studied in models of these disorders, however differences in fear response behaviours are often overlooked. We aim to examine fear behaviour and its cellular underpinnings in a rat model of ASD/ID lacking Nlgn3. METHODS: This study uses a range of behavioural tests to understand differences in fear response behaviour in Nlgn3-/y rats...
July 18, 2022: Molecular Autism