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fear generalisation

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https://www.readbyqxmd.com/read/29561204/safety-and-efficacy-of-maintenance-ketamine-treatment-in-patients-with-treatment-refractory-generalised-anxiety-and-social-anxiety-disorders
#1
Paul Glue, Shona M Neehoff, Natalie J Medlicott, Andrew Gray, Guy Kibby, Neil McNaughton
OBJECTIVE: In this maintenance treatment study, we sought to evaluate the effect on anxiety ratings, safety and tolerability of 3 months of weekly ketamine in 20 patients with treatment-refractory DSM IV generalised anxiety disorder (GAD) and/or social anxiety disorder (SAD), and subsequent assessment of remission post-treatment. METHODS: This was an uncontrolled open-label study in 20 patients who had been responders in an ascending dose ketamine study. The study was undertaken in a university clinic...
March 1, 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29549751/attention-avoidance-of-the-threat-conditioned-stimulus-during-extinction-increases-physiological-arousal-generalisation-and-retention
#2
Karina R O'Malley, Allison M Waters
Exposure therapy is a key component of efficacious treatment for anxiety. Biases in the allocation of attention towards versus away from threat assessed prior to exposure-based treatments such as cognitive-behavioural therapy differentially predict treatment outcomes. However, it is unclear whether monitoring versus avoiding threat stimuli influences learning during exposure. Extinction paradigms are the experimental analogue of exposure therapy. Therefore, manipulating attention towards versus away from threat during extinction trials may shed light on the role of attention during exposure therapy...
March 6, 2018: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/29516769/author-accepted-manuscript-rule-based-processes-in-generalisation-and-peak-shift-in-human-fear-conditioning
#3
Ola Ahmed, Peter Lovibond
No abstract text is available yet for this article.
January 1, 2018: Quarterly Journal of Experimental Psychology: QJEP
https://www.readbyqxmd.com/read/29487858/noise-sensitivities-in-dogs-an-exploration-of-signs-in-dogs-with-and-without-musculoskeletal-pain-using-qualitative-content-analysis
#4
Ana Luisa Lopes Fagundes, Lynn Hewison, Kevin J McPeake, Helen Zulch, Daniel Simon Mills
Noise sensitivity is a common behaviour problem in dogs. In humans, there is a well-established relationship between painful conditions and the development of fear-related avoidance responses. Whilst it is likely that a relationship exists between noise sensitivity and pain in dogs, this does not appear to have been investigated. The aim of this study was to explore the signs of noise sensitivity in dogs with and without musculoskeletal pain by comparing case histories using qualitative content analysis. Data were extracted from the clinical records of 20 cases of dogs presenting with noise sensitivity seen by clinical animal behaviourists at the University of Lincoln, composed of 2 groups-10 "clinical cases" with pain and 10 "control cases" without pain...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29479321/trypophobia-what-do-we-know-so-far-a-case-report-and-comprehensive-review-of-the-literature
#5
Juan Carlos Martínez-Aguayo, Renzo C Lanfranco, Marcelo Arancibia, Elisa Sepúlveda, Eva Madrid
In this article, we describe the case of a girl who suffers from a phobia to repetitive patterns, known as trypophobia. This condition has not yet been recognised by diagnostic taxonomies such as the Diagnostic and Statistical Manual of Mental Disorders. Trypophobia usually involves an intense and disproportionate fear towards holes, repetitive patterns, protrusions, etc., and, in general, images that present high-contrast energy at low and midrange spatial frequencies. It is commonly accompanied by neurovegetative symptoms...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29282161/generalisation-of-fear-in-ptsd-related-to-prolonged-childhood-maltreatment-an-experimental-study
#6
Janine Thome, Sophie Hauschild, Georgia Koppe, Lisa Liebke, Sophie Rausch, Julia I Herzog, Meike Müller-Engelmann, Regina Steil, Kathlen Priebe, Dirk Hermans, Christian Schmahl, Martin Bohus, Stefanie Lis
BACKGROUND: Fear responses are particularly intense and persistent in post-traumatic stress disorder (PTSD), and can be evoked by unspecific cues that resemble the original traumatic event. Overgeneralisation of fear might be one of the underlying mechanisms. We investigated the generalisation and discrimination of fear in individuals with and without PTSD related to prolonged childhood maltreatment. METHODS: Sixty trauma-exposed women with (N = 30) and without (N = 30) PTSD and 30 healthy control participants (HC) underwent a fear conditioning and generalisation paradigm...
December 28, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/29259187/the-interhemispheric-ca1-circuit-governs-rapid-generalisation-but-not-fear-memory
#7
Heng Zhou, Gui-Jing Xiong, Liang Jing, Ning-Ning Song, De-Lin Pu, Xun Tang, Xiao-Bing He, Fu-Qiang Xu, Jing-Fei Huang, Ling-Jiang Li, Gal Richter-Levin, Rong-Rong Mao, Qi-Xin Zhou, Yu-Qiang Ding, Lin Xu
Encoding specificity theory predicts most effective recall by the original conditions at encoding, while generalization endows recall flexibly under circumstances which deviate from the originals. The CA1 regions have been implicated in memory and generalization but whether and which locally separated mechanisms are involved is not clear. We report here that fear memory is quickly formed, but generalization develops gradually over 24 h. Generalization but not fear memory is impaired by inhibiting ipsilateral (ips) or contralateral (con) CA1, and by optogenetic silencing of the ipsCA1 projections onto conCA1...
December 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/29045812/facial-emotion-perception-in-patients-with-epilepsy-a-systematic-review-with-meta-analysis
#8
REVIEW
Michelle Edwards, Elizabeth Stewart, Romina Palermo, Suncica Lah
Facial emotion perception is a fundamental social competency relying on a specialised, yet distributed, neural network. This review aimed to determine whether patients with epilepsy have facial emotion perception accuracy impairments overall, or for a subset of emotions (anger, disgust, happiness, sadness, fear, and surprise), and the relationship to epilepsy type, demographic/treatment variables, and brain organisation. Database searches used PRISMA guidelines with strict inclusion/exclusion criteria. Thirty included studies assessed patients with temporal lobe (TLE; n=709), frontocentral (FCE; n=22), and genetic generalised (GGE; n=48) epilepsy...
December 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28865934/rule-based-generalisation-in-single-cue-and-differential-fear-conditioning-in-humans
#9
Alex H K Wong, Peter F Lovibond
Fear generalisation refers to the spread of conditioned fear to stimuli similar but distinct from the original conditioned stimulus. In this study, participants were presented with repeated pairings of a conditioned stimulus with a shock, in either a single-cue or differential conditioning paradigm. Generalisation of fear was then tested by presenting stimuli that were novel, but similar to the conditioned stimulus along a spatial stimulus dimension. Dependent measures were online shock expectancy ratings and skin conductance level...
September 1, 2017: Biological Psychology
https://www.readbyqxmd.com/read/28814971/quality-of-life-in-anxious-adolescents
#10
Solfrid Raknes, Ståle Pallesen, Joseph A Himle, Jon Fauskanger Bjaastad, Gro Janne Wergeland, Asle Hoffart, Kari Dyregrov, Åshild Tellefsen Håland, Bente Storm Mowatt Haugland
PURPOSE: To examine associations between health-related quality of life (HRQoL) and anxiety symptoms across anxiety domains (obsessions/compulsions, social anxiety, panic disorder, agoraphobia, separation anxiety, physical injury fears, generalised anxiety, and posttraumatic stress) in a general adolescent population. Expanded knowledge about these associations can provide valuable information for improving interventions and prevention strategies for adolescent anxiety. METHODS: Cross-sectional data about anxiety were collected via a school survey from a community sample of Norwegian adolescents aged 12-17 (N = 1719)...
2017: Child and Adolescent Psychiatry and Mental Health
https://www.readbyqxmd.com/read/28691571/women-s-reasons-for-choosing-abortion-method-a-systematic-literature-review
#11
Charlotte Kanstrup, Marjukka Mäkelä, Anette Hauskov Graungaard
AIMS: We aim to describe and classify reasons behind women's choice between medical and surgical abortion. METHODS: A systematic literature review was conducted in PubMed and PsycINFO in October 2015. The subjects were women in early pregnancy opting for abortion at clinics or hospitals in high-income countries. We extracted women's reasons for choice of abortion method and analysed these qualitatively, looking at main reasons for choosing either medical or surgical abortion...
July 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/28621259/clinical-effectiveness-and-cost-effectiveness-of-a-multifaceted-podiatry-intervention-for-falls-prevention-in-older-people-a-multicentre-cohort-randomised-controlled-trial-the-reducing-falls-with-orthoses-and-a-multifaceted-podiatry-intervention-trial
#12
Sarah Cockayne, Sara Rodgers, Lorraine Green, Caroline Fairhurst, Joy Adamson, Arabella Scantlebury, Belen Corbacho, Catherine E Hewitt, Kate Hicks, Robin Hull, Anne-Maree Keenan, Sarah E Lamb, Caroline McIntosh, Hylton B Menz, Anthony Redmond, Zoe Richardson, Wesley Vernon, Judith Watson, David J Torgerson
BACKGROUND: Falls are a serious cause of morbidity and cost to individuals and society. Evidence suggests that foot problems and inappropriate footwear may increase the risk of falling. Podiatric interventions could help reduce falls; however, there is limited evidence regarding their clinical effectiveness and cost-effectiveness. OBJECTIVES: To determine the clinical effectiveness and cost-effectiveness of a multifaceted podiatry intervention for preventing falls in community-dwelling older people at risk of falling, relative to usual care...
April 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28385510/classical-conditioning-differences-associated-with-chronic-pain-a-systematic-review
#13
REVIEW
Daniel S Harvie, G Lorimer Moseley, Susan L Hillier, Ann Meulders
Prominent clinical models of chronic pain propose a fundamental role of classical conditioning in the development of pain-related disability. If classical conditioning is key to this process, then people with chronic pain may show a different response to pain-related conditioned stimuli than healthy control subjects. We set out to determine whether this is the case by undertaking a comprehensive and systematic review of the literature. To identify studies comparing classical conditioning between people with chronic pain and healthy control subjects, the databases MEDLINE, PsychINFO, PsychARTICLES, Scopus, and CINAHL were searched using key words and medical subject headings consistent with 'classical conditioning' and 'pain...
August 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28356140/clinical-course-and-prognosis-of-musculoskeletal-pain-in-patients-referred-for-physiotherapy-does-pain-site-matter
#14
Nils-Bo de Vos Andersen, Peter Kent, Jakob Hjort, David Høyrup Christiansen
BACKGROUND: Danish patients with musculoskeletal disorders are commonly referred for primary care physiotherapy treatment but little is known about their general health status, pain diagnoses, clinical course and prognosis. The objectives of this study were to 1) describe the clinical course of patients with musculoskeletal disorders referred to physiotherapy, 2) identify predictors associated with a satisfactory outcome, and 3) determine the influence of the primary pain site diagnosis relative to those predictors...
March 29, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28298187/icanadapt-early-protocol-randomised-controlled-trial-rct-of-clinician-supervised-transdiagnostic-internet-delivered-cognitive-behaviour-therapy-icbt-for-depression-and-or-anxiety-in-early-stage-cancer-survivors-vs-treatment-as-usual
#15
RANDOMIZED CONTROLLED TRIAL
M J Murphy, J M Newby, P Butow, L Kirsten, K Allison, S Loughnan, M A Price, J Shaw, H Shepherd, J Smith, G Andrews
BACKGROUND: This RCT with two parallel arms will evaluate the efficacy of an internet-delivered transdiagnostic cognitive behavioural therapy (iCBT) intervention for the treatment of clinical depression and/or anxiety in early stage cancer survivors. METHODS/DESIGN: Early stage cancer survivors will be recruited via the research arm of a not-for-profit clinical research unit and randomised to an intervention (iCBT) group or a 'treatment as usual' (TAU) control group...
March 15, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28283563/a-rapid-subcortical-amygdala-route-for-faces-irrespective-of-spatial-frequency-and-emotion
#16
Jessica McFadyen, Martial Mermillod, Jason B Mattingley, Veronika Halász, Marta I Garrido
There is significant controversy over the existence and function of a direct subcortical visual pathway to the amygdala. It is thought that this pathway rapidly transmits low spatial frequency information to the amygdala independently of the cortex, and yet the directionality of this function has never been determined. We used magnetoencephalography to measure neural activity while human participants discriminated the gender of neutral and fearful faces filtered for low or high spatial frequencies. We applied dynamic causal modeling to demonstrate that the most likely underlying neural network consisted of a pulvinar-amygdala connection that was uninfluenced by spatial frequency or emotion, and a cortical-amygdala connection that conveyed high spatial frequencies...
April 5, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28223059/fear-of-future-terrorism-associated-psychiatric-burden
#17
T Abiola, O Udofia, T L Sheikh, D A Yusuf
BACKGROUND: The mental health burden from fear of future terrorism has not been given much research attention compared to the immediate mental distress such as post-traumatic stress disorder (PTSD). Such neglected ongoing mental health morbidity associated with threats of terrorism had been described as pre-traumatic stress syndrome (PTSS). OBJECTIVE: The study highlighted this phenomenon (PTSS) in Nigeria by examining the catastrophic burden of the fear of future terrorism and associated psychiatric burden among adult population in Kaduna city...
February 4, 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/28215661/post-deployment-screening-for-mental-disorders-and-tailored-advice-about-help-seeking-in-the-uk-military-a-cluster-randomised-controlled-trial
#18
Roberto J Rona, Howard Burdett, Mizanur Khondoker, Melanie Chesnokov, Kevin Green, David Pernet, Norman Jones, Neil Greenberg, Simon Wessely, Nicola T Fear
BACKGROUND: The effectiveness of post-deployment screening for mental disorders has not been assessed in a randomised controlled trial. We aimed to assess whether post-deployment screening for post-traumatic stress disorder (PTSD), depression, anxiety, or alcohol misuse was effective. We defined screening as the presumptive identification of a previously unrecognised disorder using tests to distinguish those who probably had the disorder from those who probably did not so that those people with a probable disorder could be referred appropriately, and assessed effectiveness and consequences for help-seeking by the odds ratio at follow-up between those receiving tailored help-seeking advice and those who received general mental health advice...
April 8, 2017: Lancet
https://www.readbyqxmd.com/read/28050706/identifying-disordered-eating-behaviours-in-adolescents-how-do-parent-and-adolescent-reports-differ-by-sex-and-age
#19
Savani Bartholdy, Karina Allen, John Hodsoll, Owen G O'Daly, Iain C Campbell, Tobias Banaschewski, Arun L W Bokde, Uli Bromberg, Christian Büchel, Erin Burke Quinlan, Patricia J Conrod, Sylvane Desrivières, Herta Flor, Vincent Frouin, Jürgen Gallinat, Hugh Garavan, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Michael N Smolka, Eva Mennigen, Henrik Walter, Robert Whelan, Gunter Schumann, Ulrike Schmidt
This study investigated the prevalence of disordered eating cognitions and behaviours across mid-adolescence in a large European sample, and explored the extent to which prevalence ratings were affected by informant (parent/adolescent), or the sex or age of the adolescent. The Development and Well-Being Assessment was completed by parent-adolescent dyads at age 14 (n = 2225) and again at age 16 (n = 1607) to explore the prevalence of 7 eating disorder symptoms (binge eating, purging, fear of weight gain, distress over shape/weight, avoidance of fattening foods, food restriction, and exercise for weight loss)...
June 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/27984787/pathways-from-uncertainty-to-anxiety-an-evaluation-of-a-hierarchical-model-of-trait-and-disorder-specific-intolerance-of-uncertainty-on-anxiety-disorder-symptoms
#20
Sarah Shihata, Peter M McEvoy, Barbara A Mullan
Uncertainty is central to anxiety-related pathology and intolerance of uncertainty (IU) appears to be a transdiagnostic risk and maintaining factor. The aim of the present study was to evaluate a hierarchical model to identify the unique contributions of trait and disorder-specific IU (i.e., uncertainty specific to generalised anxiety disorder, social anxiety, obsessive compulsive disorder, and panic disorder) to disorder-specific symptoms, beyond other disorder-specific cognitive vulnerabilities (i.e., negative metacognitive beliefs, fear of negative evaluation, inflated responsibility, and agoraphobic cognitions, respectively)...
January 2017: Journal of Anxiety Disorders
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