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coccidioidomycosis

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https://www.readbyqxmd.com/read/27903576/first-reported-case-of-peroneal-tenosynovitis-caused-by-coccidioides-immitis-successfully-treated-with-fluconazole
#1
Aneela Majeed, Waqas Ullah, Auon Abbas Hamadani, Anca Georgescu
Coccidioidomycosis is an insidious infection caused by Coccidioides spp (C. immitis and C. posadasii). Disseminated disease occasionally involves tendon sheaths and synovium of the joints leading to tenosynovitis. Here, we describe the case of a 72-year-old woman from southern Arizona, who presented with right ankle pain, redness and swelling for 2 months. Her serum IgG was positive for C. immitis on complement fixation, and her MRI of the right ankle joint showed extensive tenosynovitis of the right peroneal tendons, and subtalar joint effusions with associated synovitis...
November 30, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27851559/1924-a-rare-case-of-ards-from-overwhelming-coccidioidomycosis
#2
Erik Dong, Phillip Zakowski, Joshua Chung, Michael Nurok, Oren Friedman
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27851532/1897-unique-enhanced-susceptibility-of-hla-drb1-alleles-leading-to-severe-pulmonary-coccidioidomycosis
#3
Kenneth Juenger, Daya Upadhyay
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27744308/ast-to-alt-ratio-is-elevated-in-disseminated-histoplasmosis-as-compared-to-localized-pulmonary-disease-and-other-endemic-mycoses
#4
Andrej Spec, Christopher R Barrios, Usama Ahmad, Laurie A Proia
Severe pulmonary or disseminated histoplasmosis often necessitates presumptive antifungal treatment while awaiting definitive diagnosis. Histoplasma antigen assays have improved sensitivity but results may lag up to 7 days. In order to increase diagnostic certainty, "soft clues" may be looked for in laboratory and radiologic data, such as elevated alkaline phosphatase or ferritin levels and findings of mediastinal adenopathy or hepatosplenomegaly. To determine if elevated aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio is specific to histoplasmosis or a non-specific marker for disseminated fungal infection or sepsis in general, we retrospectively examined records of all patients diagnosed with an endemic fungal infection (EFI) at Rush University Medical Center from January of 1997 to October of 2012, and a cohort of septic patients with elevated liver enzymes...
October 14, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/27740893/coccidioidomycosis-surgical-issues-and-implications
#5
Joseph D Forrester, Haiwei Henry Guo, Thomas G Weiser
BACKGROUND: Coccidioidomycosis, commonly called "valley fever," "San Joaquin fever," "desert fever," or "desert rheumatism," is a multi-system illness caused by infection with Coccidioides fungi (C. immitis or C. posadasii). This organism is endemic to the desert Southwest regions of the United States and Mexico and to parts of South America. The manifestations of infection occur along a spectrum from asymptomatic to mild self-limited fever to severe disseminated disease. METHODS: Review of the English-language literature...
October 14, 2016: Surgical Infections
https://www.readbyqxmd.com/read/27724885/the-habitat-of-coccidioides-spp-and-the-role-of-animals-as-reservoirs-and-disseminators-in-nature
#6
María Del Rocío Reyes-Montes, María Ameyali Pérez-Huitrón, Jorge Luis Ocaña-Monroy, María Guadalupe Frías-De-León, Erick Martínez-Herrera, Roberto Arenas, Esperanza Duarte-Escalante
BACKGROUND: Coccidioidomycosis, a potentially fatal fungal infection, is considered an emergent mycotic disease because of the increased incidence of fungal infections registered over recent years. Infection occurs through the inhalation of arthroconidia from two main species of Coccidioides: Coccidioides immitis and C. posadasii, which are both endemic to arid and semi-arid regions of North America. Coccidioides species not only infect humans but can also infect other mammals (land, aquatic, wild or domestic), reptiles and birds...
October 10, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27717191/clinicopathologic-and-histopathologic-renal-abnormalities-in-dogs-with-coccidioidomycosis
#7
L R Mehrkens, F C Mohr, J E Sykes
BACKGROUND: We observed evidence of protein-losing nephropathy in some dogs with coccidioidomycosis, suggestive of immune complex glomerulonephritis (ICGN). The goal of this study was to understand the prevalence of renal histopathologic lesions and proteinuria in dogs with coccidioidomycosis. HYPOTHESIS: Biochemical and histopathological evidence of glomerular lesions is present in dogs with coccidioidomycosis. ANIMALS: Hundred and fifty-six dogs with naturally occurring coccidioidomycosis...
September 2016: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/27703017/hospitalized-burden-and-outcomes-of-coccidioidomycosis-a-nationwide-analysis-2005-2012
#8
Ruihong Luo, Alan Greenberg, Christian D Stone
The incidence of coccidioidomycosis (CM) infection has increased over the last 20 years. We investigated recent trends of CM-associated hospitalization in the United States. patients with CM-associated hospitalization were identified from the Nationwide Inpatient Sample, 2005-2012. The outcomes of interest were the trend of annual hospitalization, in-hospital mortality, and independent risk factors for mortality. A total of 30,870 hospitalizations with CM (29,584 of adults; 1,286 of children) were identified...
October 4, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/27649029/effect-of-geography-on-the-analysis-of-coccidioidomycosis-associated-deaths-united-states
#9
Jason A Noble, Robert G Nelson, Gudeta D Fufaa, Paul Kang, Shira Chani Shafir, John N Galgiani
Because coccidioidomycosis death rates vary by region, we reanalyzed coccidioidomycosis-associated mortality in the United States by race/ethnicity, then limited analysis to Arizona and California. Coccidioidomycosis-associated deaths were shown to increase among African-Americans but decrease among Native Americans and Hispanics. Separately, in a Native American cohort, diabetes co-varied with coccidioidomycosis-associated death.
October 2016: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/27635942/treatment-considerations-in-pulmonary-coccidioidomycosis
#10
Carlos A Hartmann, Wint T Aye, Janis E Blair
INTRODUCTION: Coccidioidomycosis is an endemic fungal infection caused by the soil-dwelling fungi, Coccidioides species. Coccidioidal infections may be asymptomatic in up to two-thirds of infected persons. Pulmonary coccidioidomycosis is the most common form of symptomatic infection. Fluconazole is the antifungal agent typically used to treat pulmonary coccidioidomycosis. Other azoles and amphotericin B products may be prescribed to treat nuanced aspects of coccidioidomycosis. AREAS COVERED: This review discusses current literature regarding medical treatment options, including the various triazoles and amphotericin B products...
October 2016: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/27617214/rare-dysuria-prostatic-abscess-due-to-disseminated-coccidioidomycosis
#11
Pedram Ansari Pirsaraei, Kareem Tabsh, Jacob Lentz
We present a case of disseminated coccidioidomycosis with formation of a prostatic abscess in a 28-year-old diabetic male. Though rare, Coccidiodes prostatitis should be included in the differential for patients who have spent time in endemic areas and present with prostatitis or other genitourinary tract symptoms, especially in the setting of immunocompromise. The small number of Coccidiodes prostatitis cases described in the literature previously are reviewed, along with a wider discussion of coccidioidomycosis...
November 2016: Urology Case Reports
https://www.readbyqxmd.com/read/27613208/mortality-from-fungal-diseases-in-the-us-air-force-from-1970-to-2013
#12
Richard K Kugblenu, Will K Reeves
We review a unique set of documents, death certificates, catalogued in the US Air Force Mortality Registry, which tracks deaths for current and retired Air Force service members. We screened the records for all deaths caused by fungal diseases between 1970 and 2013. There were 216 deaths caused by a variety of diseases such as aspergillosis, blastomycosis, candidiasis, coccidioidomycosis, cryptococcosis, histoplasmosis, mucormycosis, pneumocystosis, sporotrichosis, and zygomycosis. The single most common identified cause of death was opportunistic candidiasis...
October 2016: U.S. Army Medical Department Journal
https://www.readbyqxmd.com/read/27559032/executive-summary-2016-infectious-diseases-society-of-america-idsa-clinical-practice-guideline-for-the-treatment-of-coccidioidomycosis
#13
John N Galgiani, Neil M Ampel, Janis E Blair, Antonino Catanzaro, Francesca Geertsma, Susan E Hoover, Royce H Johnson, Shimon Kusne, Jeffrey Lisse, Joel D MacDonald, Shari L Meyerson, Patricia B Raksin, John Siever, David A Stevens, Rebecca Sunenshine, Nicholas Theodore
It is important to realize that guidelines cannot always account for individual variation among patients. They are not intended to supplant physician judgment with respect to particular patients or special clinical situations. Infectious Diseases Society of America considers adherence to these guidelines to be voluntary, with the ultimate determination regarding their application to be made by the physician in the light of each patient's individual circumstances.Coccidioidomycosis, also known as San Joaquin Valley fever, is a systemic infection endemic to parts of the southwestern United States and elsewhere in the Western Hemisphere...
September 15, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27558179/csf-1-3-beta-d-glucan-testing-is-useful-in-diagnosis-of-coccidioidal-meningitis
#14
David A Stevens, Yonglong Zhang, Malcolm A Finkelman, Pappagianis Demosthenes, Karl V Clemons, Martinez Marife
Diagnosing coccidioidal meningitis (CM) can be problematic owing to infrequency and/or delay of positivity of CSF culture or CSF antibody, particularly if primary coccidioidal infection is unrecognized. We tested 37 CSF specimens, 26 from confirmed CM and 11 from patients with suspected microbial meningitis without fungal diagnosis, for (1, 3)-beta glucan (BG). CM CSF specimens BG ranged from 18-3300 pg/ml, controls <3.9-103. Diagnostic performance was determined using 31 pg/ml cutoff (bottom of serum range per directions for commercial kit, though further serial dilutions of the standard indicated linearity to 3...
August 24, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27557127/integrative-medicine-preferences-among-coccidioidomycosis-valley-fever-patients
#15
Jack H Short, Constance Bradley, Janis E Blair, Terry D Stewart, Mark W Burns, Roberto L Patron, Denise M Millstine
OBJECTIVES: To understand the extent and modalities of integrative medicine strategies that patients with coccidioidomycosis (valley fever) have incorporated into their treatment regimens. DESIGN: A direct patient survey was distributed, with 100 unique responses, at a single infectious diseases clinic at an academic medical center in Arizona. Eligible patients, defined as those with confirmed coccidioidomycosis or currently under evaluation, were polled on their personal use of 36 integrative medicine modalities...
August 24, 2016: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/27546806/total-and-lectin-binding-proteome-of-spherulin-from-coccidioides-posadasii
#16
Thomas E Grys, Setu Kaushal, Yasmynn Chowdhury, Surendra Dasari, Natalie Michelle Mitchell, D Mitchell Magee, Janis E Blair, Thomas V Colby, Douglas F Lake
Coccidioides is a virulent dimorphic fungus that causes coccidioidomycosis (valley fever) in mammals, including humans. Although the genome has been sequenced, a proteomic analysis does not exist. To address this gap in proteomic knowledge, we generated the proteome of spherulin (a well-studied lysate of fungal spherules) and identified 1390 proteins. Some of the proteins included glycosylation enzymes, which led us to hypothesize that fungal glycosylation patterns may be different from those of mammals and could be exploited to detect Coccidioides in tissues...
October 7, 2016: Journal of Proteome Research
https://www.readbyqxmd.com/read/27516109/case-of-coccidioidomycosis-in-ireland
#17
Patrick Thomas Duggan, Alexander P Deegan, Timothy J McDonnell
Coccidioidal infection is a well-recognised cause of pulmonary disease in certain parts of the south-western USA, Central and South America; however, it is rarely encountered elsewhere in the world. We describe the case of a previously healthy man presenting to a Dublin hospital with fever, dry cough and chest pain, following a visit to the western USA. Despite treatment with broad-spectrum antimicrobials, the patient developed progressive bilateral pulmonary infiltrates and a large pleural effusion. After extensive investigations including CT, bronchoscopy and pleural fluid analysis, a diagnosis of pulmonary coccidioidomycosis was made...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27499249/cutaneous-involvement-in-the-deep-mycoses-a-review-part-ii-systemic-mycoses
#18
J E Carrasco-Zuber, C Navarrete-Dechent, A Bonifaz, F Fich, V Vial-Letelier, D Berroeta-Mauriziano
In the second part of this review on the deep mycoses, we describe the main systemic mycoses-paracoccidioidomycosis, coccidioidomycosis, histoplasmosis, mucormycosis, and cryptococcosis-and their cutaneous manifestations. Skin lesions are only occasionally seen in deep systemic mycoses either directly, when the skin is the route of entry for the fungus, or indirectly, when the infection has spread from a deeper focus. These cutaneous signs are often the only clue to the presence of a potentially fatal infection...
August 4, 2016: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/27492230/coccidioidomycosis-in-patients-with-selected-solid-organ-cancers-a-case-series-and-review-of-medical-literature
#19
Colin Fitterer, Zachary Berg, Thorvardur R Halfdanarson, Holenarasipur R Vikram, Shimon Kusne, Robert Orenstein, Maria Teresa Seville, Janis E Blair
Coccidioidomycosis is a common infection in the desert southwestern USA; approximately 3 % of healthy persons in Arizona alone become infected annually. Coccidioidomycosis may be severe in immunocompromised persons, but experience among patients with solid organ cancer has not been fully described. Therefore, we aimed to describe the clinical courses of patients whose cancers were complicated by coccidioidomycosis at our institution, which is located in an area with endemic Coccidioides. To do so, we conducted a retrospective review from January 1, 2000, through December 31, 2014, of all patients with breast, colorectal, or ovarian cancer whose cancer courses were complicated by coccidioidomycosis...
August 4, 2016: Mycopathologia
https://www.readbyqxmd.com/read/27481239/a-coccidioides-posadasii-cps1-deletion-mutant-is-avirulent-and-protects-mice-from-lethal-infection
#20
Hema P Narra, Lisa F Shubitz, M Alejandra Mandel, Hien T Trinh, Kurt Griffin, Adam S Buntzman, Jeffrey A Frelinger, John N Galgiani, Marc J Orbach
The CPS1 gene was identified as a virulence factor in the maize pathogen Cochliobolus heterostrophus Hypothesizing that the homologous gene in Coccidioides posadasii could be important for virulence, we created a Δcps1 deletion mutant which was unable to cause disease in three strains of mice (C57BL/6, BALB/c, or the severely immunodeficient NOD-scid,γc(null) [NSG]). Only a single colony was recovered from 1 of 60 C57BL/6 mice following intranasal infections of up to 4,400 spores. Following administration of very high doses (10,000 to 2...
October 2016: Infection and Immunity
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