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https://www.readbyqxmd.com/read/28644403/assessment-of-vulnerability-to-coccidioidomycosis-in-arizona-and-california
#1
Jennifer Shriber, Kathryn C Conlon, Kaitlin Benedict, Orion Z McCotter, Jesse E Bell
Coccidioidomycosis is a fungal infection endemic to the southwestern United States, particularly Arizona and California. Its incidence has increased, potentially due in part to the effects of changing climatic variables on fungal growth and spore dissemination. This study aims to quantify the county-level vulnerability to coccidioidomycosis in Arizona and California and to assess the relationships between population vulnerability and climate variability. The variables representing exposure, sensitivity, and adaptive capacity were combined to calculate county level vulnerability indices...
June 23, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28640687/dust-exposure-and-coccidioidomycosis-prevention-among-solar-power-farm-construction-workers-in-california
#2
Gail L Sondermeyer Cooksey, Jason A Wilken, Jennifer McNary, Debra Gilliss, Dennis Shusterman, Barbara L Materna, Duc J Vugia
OBJECTIVES: To investigate if work activities, dust exposure, and protection measures were associated with a 2011 to 2014 coccidioidomycosis outbreak among workers constructing 2 solar farms in California. METHODS: In 2013, we mailed self-administered questionnaires to employees who were onsite at the solar farms where the outbreak occurred to identify cases of clinical coccidioidomycosis and compare with asymptomatic workers by using multivariate logistic regression...
June 22, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28611563/disseminated-coccidioidomycosis-presenting-as-carcinomatosis-peritonei-and-intestinal-coccidioidomycosis-in-a-patient-with-hiv
#3
Umer Malik, Hira Cheema, Ramcharitha Kandikatla, Yasir Ahmed, Kalyan Chakrala
Coccidioidomycosis (CM) is a fungal infection endemic in southwestern regions of the United States, northwestern regions of Mexico, and some areas of Brazil and Argentina. Clinical presentation varies depending on the extent of the infection and the immune status of the host. The most common presentation ranges from flu-like symptoms to self-limiting pneumonia. Extrapulmonary presentations are uncommon and may involve the meninges, skin, and bone. Gastrointestinal and peritoneal involvement is extremely rare...
January 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/28595294/coccidioidomycosis-an-underreported-cause-of-death-arizona-2008-2013
#4
Jefferson M Jones, Lia Koski, Mohammed Khan, Shane Brady, Rebecca Sunenshine, Ken K Komatsu
In Arizona during 1997-2013, coccidioidomycosis increased from 21 to 90 cases/100,000 population, but coccidioidomycosis-associated deaths remained stable at 3-6 deaths/million population. We used the capture-recapture method by using death certificates and hospital discharge data to more fully estimate the total number of coccidioidomycosis-attributable deaths and compared this with published estimates. Death certificates were included if any cause of death included coccidioidomycosis; hospital discharge data deaths were included if any discharge diagnosis included coccidioidomycosis and laboratory confirmation...
June 8, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28584982/rational-design-of-t-lymphocyte-epitope-based-vaccines-against-coccidioides-infection
#5
Brady J Hurtgen, Chiung-Yu Hung
Coccidioidomycosis is a potentially life-threatening mycosis endemic to the Southwestern USA and some arid regions of Central and South America. A vaccine against Coccidioides infection would benefit over 30-million people who reside in or visit the endemic regions. Vaccine candidates against systemic fungal infections come in many forms. Live attenuated vaccines are derived from disease-causing pathogens and generally stimulate excellent protective immunity. Since attenuated vaccines contain living microbes, there is a degree of unpredictability raising concerns regarding safety and stability...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28577242/divergence-in-the-approach-to-tumor-necrosis-factor-%C3%AE-inhibitor-recipients-with-coccidioidomycosis
#6
Ashley L Garrett, Stephen S Cha, Elizabeth Wack, Janis E Blair
BACKGROUND: Tumor necrosis factor α-inhibitors (TNFIs) have been associated with increased risk of certain fungal infections, including coccidioidomycosis. The optimal treatment approach to coccidioidomycosis in TNFI recipients is unknown. METHODS: We constructed an anonymous, voluntary survey for practicing pulmonary and infectious disease physicians in the state of Arizona regarding approach to TNFI patients with coccidioidomycosis. RESULTS: There is no current consensus on managing these patients...
June 2, 2017: Infection
https://www.readbyqxmd.com/read/28566083/-a-case-of-coccidioidomycosis-in-turkey-imported-from-the-united-states-of-america
#7
Seniha Başaran, Nilgün Karabıçak, Serap Şimşek Yavuz, Nathan P Wiederhold, Seda Şafak, Aysun Sarıbuğa, Deanna A Sutton, Züleyha Bingöl, Atahan Çağatay, Halit Özsüt, Zeki Kılıçaslan, Haluk Eraksoy
Coccidioidomycosis caused by Coccidioides immitis or Coccidioides posadasii is a rare infectious disease except in endemic regions. In this report the third documented imported case of coccidioidomycosis in Turkey was presented. A thirty-year-old male patient was admitted to our hospital with fever and purulent drainage from his chest tube. He had worked in Arizona, USA, until 4 months before this presentation. While in Arizona, he experienced cough and hemoptysis and was diagnosed as pulmonary coccidioidomycosis...
April 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28560172/a-case-of-osteomyelitis-of-the-toe-caused-by-coccidioidomycosis-in-a-17-year-old-with-diabetes-insipidus
#8
Ahmer Khalid, Daniel J Boken, Christine A Nelson, Vicken Y Totten
We report a case of a 17-year-old male who presented with pain in his right first toe. His pain and swelling had worsened and x-rays of his foot revealed erosive changes of the great toe distal phalanx suggesting possible osteomyelitis. His co-morbidities were morbid obesity and diabetes insipidus. He was admitted to the hospital, blood cultures were drawn, and he was started on vancomycin for presumed bacterial osteomyelitis. He underwent incision and drainage of the fluctuant abscess of the toe, where a culture of the wound was taken...
2017: IDCases
https://www.readbyqxmd.com/read/28507906/a-case-of-a-positive-coccidioides-stool-culture-in-an-immunocompetent-patient-with-disseminated-coccidioidomycosis
#9
Majd Alfreijat, Brian Wilhelmi
Coccidioidomycosis (CM) is an infection caused by the coccidioides fungus. The spectrum of the disease ranges from a mild upper respiratory illness to severe disseminated infection that could affects the bones, joints, skin, central nervous system, and the gastrointestinal tract. Previous reports of a positive stool culture in the setting of disseminated CM are extremely rare. Herein, we describe a case of a 43-year-old immunocompetent patient with disseminated CM and evidence of positive coccidioides stool culture...
2017: IDCases
https://www.readbyqxmd.com/read/28452423/coccidioidomycosis-among-persons-undergoing-lung-transplantation-in-the-coccidioidal-endemic-region
#10
Sachin Chaudhary, Laura Meinke, Huthayfa Ateeli, Kenneth S Knox, Yuval Raz, Neil M Ampel
BACKGROUND: Coccidioidomycosis, an endemic fungal infection, is more likely to be symptomatic and severe among those receiving allogeneic transplants. While several case series have been published for various transplanted organs, none has described the incidence and outcomes in those receiving lung transplants within the coccidioidal endemic region. METHODS: Patients receiving a heart-lung, single-lung, or bilateral-lung transplantation at the University of Arizona between 1985 and 2009 were retrospectively reviewed...
April 28, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28386282/ulcerated-lesion-of-the-tongue-as-manifestation-of-systemic-coccidioidomycosis
#11
Luis A Mendez, Sergio A Flores, Ricardo Martinez, Oslei Paes de Almeida
Systemic mycoses and their oral manifestations are very rare. We present a case of a 60-year-old man with an ulcerated lesion on the lateral border of the tongue. Histologic studies revealed a granulomatous fungal infection by Coccidioides immitis. After pharmacological treatment, the lesion resolved. Recently, northern Mexico has been reported to be an endemic zone of C. immitis infections; therefore it should be considered in the differential diagnosis of mouth lesions. A comprehensive clinical history, physical exploration, and complementary studies are essential for an accurate diagnosis...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28380017/development-of-an-enzyme-immunoassay-for-detection-of-antibodies-against-coccidioides-in-dogs-and-other-mammalian-species
#12
Nancy A Chow, Mark D Lindsley, Orion Z McCotter, Dave Kangiser, Ron D Wohrle, Wayne R Clifford, Hayley D Yaglom, Laura E Adams, Kenneth Komatsu, Michelle M Durkin, Rocky J Baker, Lisa F Shubitz, Gordana Derado, Tom M Chiller, Anastasia P Litvintseva
Coccidioides is a soil-dwelling fungus that causes coccidioidomycosis, a disease also known as Valley fever, which affects humans and a variety of animal species. Recent findings of Coccidioides in new, unexpected areas of the United States have demonstrated the need for a better understanding of its geographic distribution. Large serological studies on animals could provide important information on the geographic distribution of this pathogen. To facilitate such studies, we used protein A/G, a recombinant protein that binds IgG antibodies from a variety of mammalian species, to develop an enzyme immunoassay (EIA) that detects IgG antibodies against Coccidioides in a highly sensitive and high-throughput manner...
2017: PloS One
https://www.readbyqxmd.com/read/28317569/oral-fungal-infections-diagnosis-and-management
#13
REVIEW
David R Telles, Niraj Karki, Michael W Marshall
Oral and maxillofacial fungal infections can appear in high-risk patients, including those immunocompromised. This article explores common oral manifestations of fungal infections in the oral cavity as primary lesions or as a result of disseminated disease. By far the most common oral fungal infection experienced in dentistry is oral candidiasis, which is reviewed in depth from simple oral infections to invasive candidiasis. The review aids the dental practitioner in understanding the full scope of Candida infections and other fungal infections...
April 2017: Dental Clinics of North America
https://www.readbyqxmd.com/read/28300772/immune-response-to-coccidioidomycosis-and-the-development-of-a-vaccine
#14
REVIEW
Natalia Castro-Lopez, Chiung-Yu Hung
Coccidioidomycosis is a fungal infection caused by Coccidioides posadasii and Coccidioides immitis. It is estimated that 150,000 new infections occur in the United States each year. The incidence of this infection continues to rise in endemic regions. There is an urgent need for the development of better therapeutic drugs and a vaccine against coccidioidomycosis. This review discusses the features of host innate and adaptive immune responses to Coccidioides infection. The focus is on the recent advances in the immune response and host-pathogen interactions, including the recognition of spherules by the host and defining the signal pathways that guide the development of the adaptive T-cell response to Coccidioides infection...
March 16, 2017: Microorganisms
https://www.readbyqxmd.com/read/28289027/efficacy-of-the-investigational-antifungal-vt-1161-in-treating-naturally-occurring-coccidioidomycosis-in-dogs
#15
Lisa F Shubitz, Michael E Roy, Hien T Trinh, William J Hoekstra, Robert J Schotzinger, Edward P Garvey
Coccidioidomycosis can be a chronic, systemic fungal infection requiring long-term to lifetime medication. Thus, there is a need for improved antifungal agents with greater efficacy and reduced toxicity. VT-1161 has a low affinity for mammalian cytochromes and potently inhibits fungal CYP51 with proven efficacy in murine models of central nervous system (CNS) and respiratory coccidioidomycosis. Dogs experience coccidioidomycosis similar to humans and are a useful preclinical model for naturally occurring disease...
May 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28228898/disseminated-coccidioidomycosis-with-multifocal-musculoskeletal-disease-involvement
#16
Michael F McConnell, Ann Shi, Todd M Lasco, Luke Yoon
We report a rare case of disseminated coccidioidomycosis with multifocal musculoskeletal involvement. The patient presented to the emergency department with left shoulder pain and swelling. Magnetic resonance imaging of the left shoulder revealed enhancing soft tissue masses, bony lesions, and fluid collections in and around the glenohumeral joint with involvement of the proximal humerus, glenoid, and rotator cuff musculature. Multiple additional areas of involvement were subsequently discovered. Fungal cultures confirmed coccidioidomycosis infection at all surgical sites with superimposed polymicrobial bacterial infection in the left shoulder...
March 2017: Radiology case reports
https://www.readbyqxmd.com/read/28166146/bone-scan-pet-ct-and-mri-in-disseminated-coccidioidomycosis
#17
John Randolph Dryden, Michael David Starsiak, Mickaila James Johnston, Eugene David Silverman
Coccidioidomycosis (valley fever) is a systemic fungal infection resulting from inhalation of the Coccidioides immitis or posadasii spores. In many cases, infection causes a self-limited community-acquired pneumonia; however, in patients with risk factors, such as immunosuppression or African or Pacific Island ancestry, significant morbidity and mortality from disseminated disease may occur. Presented here are comparative images using Tc-MDP bone scan, F-FDG PET/CT, and MRI. Each demonstrates particular strengths, which aid in assessing the extent of systemic involvement of a biopsy-proven case of disseminated coccidioidomycosis...
April 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28143444/peritoneal-and-genital-coccidioidomycosis-in-an-otherwise-healthy-danish-female-a-case-report
#18
Ole Bæk, Karen Astvad, Reza Serizawa, Lawrence J Wheat, Pia T Brenøe, Ann-Brit E Hansen
BACKGROUND: Coccidioidomycosis is a fungal infection that usually presents as a primary lung infection. The fungus is endemic to the Southwest United States of America, northern Mexico and parts of Central and South America the infection is rare outside these areas. However, some patients develop disseminated infection that can lie dormant for several years and can present itself in travelers. We report the first case of extra pulmonary Coccidioidomycosis in a non-immunocompromised individual in Denmark...
January 31, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28134743/donor-related-coccidioidomycosis-transmitted-through-left-liver-transplant-to-a-child-recipient-in-a-non-endemic-area
#19
Corentin Tanné, Frédérique Dijoud, Meja Rabodonirina, Damien Dupont, Christine Rivet, Sophie Collardeau-Frachon, Yves Gillet, Rémi Dubois, Frédéric Hameury, Jérome Dumortier, Alain Lachaux
This first observation of donor-transmitted cocciodioidomycosis to a pediatric liver transplant recipient underlines a rare condition in transplanted patients in a non-endemic area. Moreover, this transmission was observed following a liver split, the patient being contaminated by the left liver while the right liver recipient was not.
January 26, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28098554/risk-factors-for-disseminated-coccidioidomycosis-united-states
#20
Camila D Odio, Beatriz E Marciano, John N Galgiani, Steven M Holland
Of 150,000 new coccidioidomycosis infections that occur annually in the United States, ≈1% disseminate; one third of those cases are fatal. Immunocompromised hosts have higher rates of dissemination. We identified 8 patients with disseminated coccidioidomycosis who had defects in the interleukin-12/interferon-γ and STAT3 axes, indicating that these are critical host defense pathways.
February 2017: Emerging Infectious Diseases
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