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Creativity and bipolar disorder

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https://www.readbyqxmd.com/read/28692485/safety-and-tolerability-of-cariprazine-in-patients-with-acute-exacerbation-of-schizophrenia-a-pooled-analysis-of-four-phase-ii-iii-randomized-double-blind-placebo-controlled-studies
#1
Willie Earley, Suresh Durgam, Kaifeng Lu, István Laszlovszky, Marc Debelle, John M Kane
Cariprazine, a potent dopamine D3 and D2 receptor partial agonist antipsychotic with preferential binding to D3 receptors, is Food and Drug Administration approved for treating schizophrenia and manic or mixed episodes of bipolar I disorder. A post-hoc safety/tolerability analysis of data from the four acute trials in the cariprazine schizophrenia clinical development program (NCT00404573; NCT00694707; NCT01104766; NCT01104779) was carried out using the overall safety population (all patients who received ≥1 dose of study drug) and modal daily dose subgroups (1...
July 7, 2017: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28686561/-the-concept-of-temperament-and-its-contribution-to-the-understanding-of-the-bipolar-spectrum
#2
I Koufaki, V Polizoidou, K N Fountoulakis
The present article attempts first to provide a historical overview of the concept of temperament,The present article attempts first to provide a historical overview of the concept of temperament,since its foundation by Polybos (4th century B.C.) and the school of Cos, its predominant role in theshaping of the anthropological and humanitarian sciences, until the modern theoretical formulations,such as those proposed by Robert Cloninger and Hagop Akiskal. Secondly, recent literature ispresented, which suggests a strong link of different temperament structures to mental health andpsychopathology...
April 2017: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/28507774/footnotes-to-kraepelin-changes-in-the-classification-of-mood-disorders-with-dsm-5
#3
EDITORIAL
Nicola J Kalk, Allan H Young
SUMMARY: Reliable diagnosis of mood disorders continues to pose a challenge. This is surprising because they have been recognised clinically since classical times. Mood disorders are also common: major depressive disorder affects nearly 300 million people worldwide and bipolar affective disorder nearly 60 million and they are a major cause of disability. Nonetheless, the reliability trials of the updated Diagnostic and Statistical Manual, Fifth Edition (DSM-5) found that the reliability of the diagnosis of major depressive disorder was in the 'questionable' range...
May 2017: BJPsych Open
https://www.readbyqxmd.com/read/28357133/the-association-between-self-reported-and-clinically-determined-hypomanic-symptoms-and-the-onset-of-major-mood-disorders
#4
Sarah Margaret Goodday, Martin Preisig, Mehdi Gholamrezaee, Paul Grof, Jules Angst, Anne Duffy
BACKGROUND: Hypomanic symptoms may be a useful predictor of mood disorder among young people at high risk for bipolar disorder. AIMS: To determine whether hypomanic symptoms differentiate offspring of parents with bipolar disorder (high risk) and offspring of well parents (control) and predict the development of mood episodes. METHOD: High-risk and control offspring were prospectively assessed using semi-structured clinical interviews annually and completed the Hypomania Checklist-32 Revised (HCL-32)...
March 2017: BJPsych Open
https://www.readbyqxmd.com/read/28340448/structural-correlates-of-creative-thinking-in-patients-with-bipolar-disorder-and-healthy-controls-a-voxel-based-morphometry-study
#5
Pei-Chi Tu, Yi-Hsuan Kuan, Cheng-Ta Li, Tung-Ping Su
BACKGROUND: This study investigated the structural correlates of creative thinking in patients with bipolar disorder (BD) to understand the possible neural mechanism of creative thinking in BD. METHODS: We recruited 59 patients with BD I or BD II (35.3±8.5 y) and 56 age- and sex-matched controls (HCs; 34±7.4 y). Each participant underwent structural magnetic resonance imaging and evaluation of creative thinking, which was assessed using two validated tools: the Chinese version of the Abbreviated Torrance Test for Adults for divergent thinking and the Chinese Word Remote Associates Test for remote association...
June 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28288308/the-link-between-hypomania-risk-and-creativity-the-role-of-heightened-behavioral-activation-system-bas-sensitivity
#6
Bin-Na Kim, Seok-Man Kwon
BACKGROUND: The relationship between bipolar disorder (BD) and creativity is well-known; however, relatively little is known about its potential mechanism. We investigated whether heightened behavioral activation system (BAS) sensitivity may mediate such relationship. METHODS: Korean young adults (N=543) completed self-report questionnaires that included the Hypomanic Personality Scale (HPS), the Behavioral Activation System(BAS) Scale, the Everyday Creativity Scale (ECS), the Positive Affect and Negative Affect Schedule (PANAS), and the Altman Self-Rating Mania Scale (ASRM)...
June 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28277566/positive-traits-in-the-bipolar-spectrum-the-space-between-madness-and-genius
#7
REVIEW
Tiffany A Greenwood
Bipolar disorder is a severe, lifelong mood disorder for which little is currently understood of the genetic mechanisms underlying risk. By examining related dimensional phenotypes, we may further our understanding of the disorder. Creativity has a historical connection with the bipolar spectrum and is particularly enhanced among unaffected first-degree relatives and those with bipolar spectrum traits. This suggests that some aspects of the bipolar spectrum may confer advantages, while more severe expressions of symptoms negatively influence creative accomplishment...
February 2017: Molecular Neuropsychiatry
https://www.readbyqxmd.com/read/27847590/interhemispheric-functional-disconnection-because-of-abnormal-corpus-callosum-integrity-in-bipolar-disorder-type-ii
#8
Fumihiko Yasuno, Takashi Kudo, Kiwamu Matsuoka, Akihide Yamamoto, Masato Takahashi, Jyoji Nakagawara, Kazuyuki Nagatsuka, Hidehiro Iida, Toshifumi Kishimoto
BACKGROUND: A significantly lower fractional anisotropy (FA) value has been shown in anterior parts of the corpus callosum in patients with bipolar disorder. AIMS: We investigated the association between abnormal corpus callosum integrity and interhemispheric functional connectivity (IFC) in patients with bipolar disorder. METHODS: We examined the association between FA values in the corpus callosum (CC-FA) and the IFC between homotopic regions in the anterior cortical structures of bipolar disorder (n=16) and major depressive disorder (n=22) patients with depressed or euthymic states...
November 2016: BJPsych Open
https://www.readbyqxmd.com/read/27749681/metabolic-abnormalities-related-to-treatment-with-selective-serotonin-reuptake-inhibitors-in-patients-with-schizophrenia-or-bipolar-disorder
#9
Katrine Kveli Fjukstad, Anne Engum, Stian Lydersen, Ingrid Dieset, Nils Eiel Steen, Ole A Andreassen, Olav Spigset
OBJECTIVE: The aim of the present study was to examine the effect of selective serotonin reuptake inhibitors (SSRIs) on cardiovascular risk factors in patients with schizophrenia or bipolar disorder. METHOD: We used data from a cross-sectional study on 1301 patients with schizophrenia or bipolar disorder, of whom 280 were treated with SSRIs. The primary outcome variable was the serum concentration of total cholesterol. Secondary outcome variables were low-density lipoprotein (LDL) cholesterol, high-density lipoprotein cholesterol, triglyceride and glucose levels, body mass index, waist circumference, and systolic and diastolic blood pressure...
December 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27703793/gadl1-variant-and-medication-adherence-in-predicting-response-to-lithium-maintenance-treatment-in-bipolar-i-disorder
#10
Chih-Ken Chen, Chau-Shoun Lee, Hsuan-Yu Chen, Lawrence Shih-Hsin Wu, Jung-Chen Chang, Chia-Yih Liu, Andrew Tai-Ann Cheng
BACKGROUND: Genetic variants and medication adherence have been identified to be the main factors contributing to lithium treatment response in bipolar disorders. AIMS: To simultaneously examine effects of variant glutamate decarboxylase-like protein 1 (GADL1) and medication adherence on response to lithium maintenance treatment in Han Chinese patients with bipolar I (BPI) disorder. METHOD: Frequencies of manic and depressive episodes between carriers and non-carriers of the effective GADL1 rs17026688 T allele during the cumulative periods of off-lithium, poor adherence to lithium treatment and good adherence to lithium treatment were compared in Han Chinese patients with BPI disorder (n=215)...
September 2016: BJPsych Open
https://www.readbyqxmd.com/read/27703792/women-with-bipolar-disorder-and-pregnancy-factors-influencing-their-decision-making
#11
Clare Dolman, Ian R Jones, Louise M Howard
BACKGROUND: Women with bipolar disorder are at increased risk of having a severe episode of illness associated with childbirth. AIMS: To explore the factors that influence the decision-making of women with bipolar disorder regarding pregnancy and childbirth. METHOD: Qualitative study with a purposive sample of women with bipolar disorder considering pregnancy, or currently or previously pregnant, supplemented by data from an online forum. Data were analysed using thematic analysis...
September 2016: BJPsych Open
https://www.readbyqxmd.com/read/27703752/low-birth-weight-and-features-of-neuroticism-and-mood-disorder-in-83%C3%A2-545-participants-of-the-uk-biobank-cohort
#12
Donald M Lyall, Hazel M Inskip, Daniel Mackay, Ian J Deary, Andrew M McIntosh, Matthew Hotopf, Tony Kendrick, Jill P Pell, Daniel J Smith
BACKGROUND: Low birth weight has been inconsistently associated with risk of developing affective disorders, including major depressive disorder (MDD). To date, studies investigating possible associations between birth weight and bipolar disorder (BD), or personality traits known to predispose to affective disorders such as neuroticism, have not been conducted in large cohorts. AIMS: To assess whether very low birth weight (<1500 g) and low birth weight (1500-2490 g) were associated with higher neuroticism scores assessed in middle age, and lifetime history of either MDD or BD...
January 2016: BJPsych Open
https://www.readbyqxmd.com/read/27703748/hospital-treatment-mortality-and-healthcare-costs-in-relation-to-socioeconomic-status-among-people-with-bipolar-affective-disorder
#13
Yi-Ju Pan, Ling-Ling Yeh, Yu-Chun Chen, Kuei-Hong Kuo, Chin-Kuo Chang
BACKGROUND: Evidence regarding the relationships between the socioeconomic status and long-term outcomes of individuals with bipolar affective disorder (BPD) is lacking. AIMS: We aimed to estimate the effects of baseline socioeconomic status on longitudinal outcomes. METHOD: A national cohort of adult participants with newly diagnosed BPD was identified in 2008. The effects of personal and household socioeconomic status were explored on outcomes of hospital treatment, mortality and healthcare costs, over a 3-year follow-up period (2008-2011)...
January 2016: BJPsych Open
https://www.readbyqxmd.com/read/27688643/genetic-findings-are-challenging-the-symptom-based-diagnostic-classification-system-of-mental-disorders
#14
Chen Zhang
The present diagnostic classification of mental illnesses is primarily based on symptomatology. A recent cross-disorder genome-wide association study revealed that there were genetic similarities between multiple clinically defined diagnoses (including schizophrenia, bipolar disorder, depression, attention deficit hyperactivity disorder, and autism spectrum disorder) on regions of chromosomes 3p21 and 10q24 and single-nucleotide polymorphisms (SNPs) within two L-type voltage-gated calcium channel subunits of CACNA1C and CACNB2...
February 25, 2016: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/27367308/positive-beliefs-about-mental-illness-associations-with-sex-age-diagnosis-and-clinical-outcomes
#15
Marie J C Forgeard, Rebecca L Pearl, Joey Cheung, Lara S Rifkin, Courtney Beard, Thröstur Björgvinsson
BACKGROUND: Beliefs about mental illness affect how individuals cope with their symptoms. Positive beliefs about mental illness (PBMI) refer to perceptions of positive attributes individuals may identify in their illness, such as beneficial consequences, enhanced creativity or cognition, or growth through adversity. METHODS: The present study developed and tested a brief measure of PBMI in 332 adults presenting for partial hospitalization with a variety of acute psychiatric conditions...
November 1, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27307187/adherence-to-antipsychotic-medication-in-bipolar-disorder-and-schizophrenic-patients-a-systematic-review
#16
REVIEW
Saínza García, Mónica Martínez-Cengotitabengoa, Saioa López-Zurbano, Iñaki Zorrilla, Purificación López, Eduard Vieta, Ana González-Pinto
Antipsychotics are the drugs prescribed to treat psychotic disorders; however, patients often fail to adhere to their treatment, and this has a severe negative effect on prognosis in these kinds of illnesses. Among the wide range of risk factors for treatment nonadherence, this systematic review covers those that are most important from the point of view of clinicians and patients and proposes guidelines for addressing them. Analyzing 38 studies conducted in a total of 51,796 patients, including patients with schizophrenia spectrum disorders and bipolar disorder, we found that younger age, substance abuse, poor insight, cognitive impairments, low level of education, minority ethnicity, poor therapeutic alliance, experience of barriers to care, high intensity of delusional symptoms and suspiciousness, and low socioeconomic status are the main risk factors for medication nonadherence in both types of disorder...
August 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27015036/effectiveness-of-inhaled-loxapine-in-dual-diagnosis-patients-a-case-series
#17
Carlos Roncero, Elena Ros-Cucurull, Lara Grau-López, Christian Fadeuilhe, Miguel Casas
OBJECTIVES: Episodes of psychotic agitation are frequent in patients with dual diagnosis, that is, in patients with concomitant psychiatric and substance use disorders. Rapid intervention is needed to treat the agitation at a mild stage to prevent the escalation to aggressive behavior. Inhaled loxapine has been demonstrated to rapidly improve symptoms of mild-to-moderate agitation in adults with psychiatric disorders (schizophrenia and bipolar disorder), but data on patients with dual diagnosis are scarce...
July 2016: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/26950008/mad-genius-revisited-vulnerability-to-psychopathology-biobehavioral-approach-avoidance-and-creativity
#18
REVIEW
Matthijs Baas, Bernard A Nijstad, Nathalie C Boot, Carsten K W De Dreu
Although many believe that creativity associates with a vulnerability to psychopathology, research findings are inconsistent. Here we address this possible linkage between risk of psychopathology and creativity in nonclinical samples. We propose that propensity for specific psychopathologies can be linked to basic motivational approach and avoidance systems, and that approach and avoidance motivation differentially influences creativity. Based on this reasoning, we predict that propensity for approach-based psychopathologies (e...
June 2016: Psychological Bulletin
https://www.readbyqxmd.com/read/26876274/neuropsychiatry-of-creativity
#19
REVIEW
Marco Mula, Bruce Hermann, Michael R Trimble
In this paper, we review in brief the development of ideas that over time have tried to explain why some individuals are more creative than others and what may be the neurobiological links underlying artistic creativity. We note associations with another unique human idea, that of genius. In particular, we discuss frontotemporal dementia and bipolar, cyclothymic mood disorder as clinical conditions that are helping to unravel the underlying neuroanatomy and neurochemistry of human creativity. This article is part of a Special Issue entitled "Epilepsy, Art, and Creativity"...
April 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/26053403/polygenic-risk-scores-for-schizophrenia-and-bipolar-disorder-predict-creativity
#20
Robert A Power, Stacy Steinberg, Gyda Bjornsdottir, Cornelius A Rietveld, Abdel Abdellaoui, Michel M Nivard, Magnus Johannesson, Tessel E Galesloot, Jouke J Hottenga, Gonneke Willemsen, David Cesarini, Daniel J Benjamin, Patrik K E Magnusson, Fredrik Ullén, Henning Tiemeier, Albert Hofman, Frank J A van Rooij, G Bragi Walters, Engilbert Sigurdsson, Thorgeir E Thorgeirsson, Andres Ingason, Agnar Helgason, Augustine Kong, Lambertus A Kiemeney, Philipp Koellinger, Dorret I Boomsma, Daniel Gudbjartsson, Hreinn Stefansson, Kari Stefansson
We tested whether polygenic risk scores for schizophrenia and bipolar disorder would predict creativity. Higher scores were associated with artistic society membership or creative profession in both Icelandic (P = 5.2 × 10(-6) and 3.8 × 10(-6) for schizophrenia and bipolar disorder scores, respectively) and replication cohorts (P = 0.0021 and 0.00086). This could not be accounted for by increased relatedness between creative individuals and those with psychoses, indicating that creativity and psychosis share genetic roots...
July 2015: Nature Neuroscience
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